LOCUS       NC_014643.1            15863 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_014643.1 Rothia dentocariosa ATCC 17931, complete sequence.
ACCESSION   NC_014643
VERSION     NC_014643.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:41:31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 655099
            Orig. end    :: 670962
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15863
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[660099:665962]"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..10863
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     cand_cluster    1..15863
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15863
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="1"
                     /rules="AfsA"
                     /tool="antismash"
     CDS             complement(669..1118)
                     /locus_tag="ctg1_580"
                     /transl_table=11
                     /translation="MTAERTADLSARIGEPLGETPWMRISQQNINRFGELTGDTQWIHT
                     DPYRAAHTPFGGTIVHGAYLLSLAITFAGQLLPAEGTSMLVNAGVSAARFRSAVPVDSQ
                     VCGSASIVSAEDFGDATLAEIRVAVHVKGQSKPATTATVRMVLHD"
     PFAM_domain     complement(759..1088)
                     /aSDomain="MaoC_dehydratas"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01575.21"
                     /description="MaoC like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_580_0001"
                     /evalue="7.70E-19"
                     /label="ctg1_580"
                     /locus_tag="ctg1_580"
                     /protein_end="120"
                     /protein_start="10"
                     /score="67.6"
                     /tool="antismash"
                     /translation="ARIGEPLGETPWMRISQQNINRFGELTGDTQWIHTDPYRAAHTPF
                     GGTIVHGAYLLSLAITFAGQLLPAEGTSMLVNAGVSAARFRSAVPVDSQVCGSASIVSA
                     EDFGDA"
     CDS             complement(1115..1768)
                     /locus_tag="ctg1_581"
                     /transl_table=11
                     /translation="MTDTPNASSAPSPDPLPPEGSDASGYPFTFYLPDLGEGLRSGEII
                     EWLISEGQQVELDQVLVVVETAKSTVEIPSPVAGTVVRLLEPVGQVVDVDAPLIELRTP
                     TPQAQAPTAGAETPAKDSADKLPAKPGAGESKHLVGRGKMPIKPGGTGTALPPKSAKTQ
                     GGKARSGAKVSPAVRRLARSLGVDLKTVTGTGAGGAITPEDVQTAADQAAGGAS"
     PFAM_domain     complement(1151..1255)
                     /aSDomain="E3_binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02817.19"
                     /description="e3 binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_581_0003"
                     /evalue="5.70E-14"
                     /label="ctg1_581"
                     /locus_tag="ctg1_581"
                     /protein_end="206"
                     /protein_start="171"
                     /score="52.2"
                     /tool="antismash"
                     /translation="KVSPAVRRLARSLGVDLKTVTGTGAGGAITPEDVQ"
     PFAM_domain     complement(1466..1681)
                     /aSDomain="Biotin_lipoyl"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00364.24"
                     /description="Biotin-requiring enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_581_0002"
                     /evalue="4.00E-19"
                     /label="ctg1_581"
                     /locus_tag="ctg1_581"
                     /protein_end="101"
                     /protein_start="29"
                     /score="68.3"
                     /tool="antismash"
                     /translation="FYLPDLGEGLRSGEIIEWLISEGQQVELDQVLVVVETAKSTVEIP
                     SPVAGTVVRLLEPVGQVVDVDAPLIEL"
     CDS             complement(1780..2859)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110:1-deoxy-D-xylulose-5-phosphate synthase (Score:
                     361.9; E-value: 3.3e-110)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_582"
                     /transl_table=11
                     /translation="MSQQAADTQVRGAKTASDTAPQAPESTQSRSDAVQRTSMVGALNL
                     ALGHEMQHNDRVVMFGVDVGTLGGVFRVTDGLTERFGEERCFDTPISEAGIMGAAIGMA
                     MYGFRPVIEMQFDAFGYPAFEQMVSNLAKMRNRTRGDLSMPVVVRMPYGGGVGAVEHHS
                     DSSEGYAAHTPGLHVYTPSNPSDAYHMLRQAIRSDDPVIFYEPKRLYWEEGDLDTSADP
                     LPIGQARICRPGEDVTLISYGPTVPMALAAAETAAEYGYSVEVIDLRTLTPFDEHTVCE
                     SVMRTGRAVMVHEAPQTGGFGAEVVARITSRCFDYLERPVERVTGLDVPYPPPGLEHLY
                     LPNEEKILGAIATLYAEND"
     PFAM_domain     complement(1819..2184)
                     /aSDomain="Transketolase_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02780.22"
                     /description="Transketolase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_582_0005"
                     /evalue="5.50E-41"
                     /label="ctg1_582"
                     /locus_tag="ctg1_582"
                     /protein_end="347"
                     /protein_start="225"
                     /score="139.4"
                     /tool="antismash"
                     /translation="GQARICRPGEDVTLISYGPTVPMALAAAETAAEYGYSVEVIDLRT
                     LTPFDEHTVCESVMRTGRAVMVHEAPQTGGFGAEVVARITSRCFDYLERPVERVTGLDV
                     PYPPPGLEHLYLPNEEKI"
     PFAM_domain     complement(2230..2748)
                     /aSDomain="Transket_pyr"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02779.26"
                     /description="Transketolase, pyrimidine binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_582_0004"
                     /evalue="2.60E-44"
                     /label="ctg1_582"
                     /locus_tag="ctg1_582"
                     /protein_end="210"
                     /protein_start="37"
                     /score="151.1"
                     /tool="antismash"
                     /translation="SMVGALNLALGHEMQHNDRVVMFGVDVGTLGGVFRVTDGLTERFG
                     EERCFDTPISEAGIMGAAIGMAMYGFRPVIEMQFDAFGYPAFEQMVSNLAKMRNRTRGD
                     LSMPVVVRMPYGGGVGAVEHHSDSSEGYAAHTPGLHVYTPSNPSDAYHMLRQAIRSDDP
                     VIFYEPKRLY"
     CDS             complement(2856..3902)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_583"
                     /sec_met_domain="DXP_synthase_N (E-value: 5.4e-08,
                     bitscore: 29.4, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPNTLQSPPQQVQNGVSDDLLITAHAAMIAGRHFNQQASNLAKQG
                     YMGAYPSSLGQEACQVAAALALEPADWLFPTYRDSVAVMSRGIDLAEVLSPFHGSSHCG
                     YAPTKTHTAPEATPLATHTAHAVGLAMAAKFAGDSTVALAMCGDGSTSEGDFHEALNLA
                     AVFEAPVVFLVQNNGYAISTPVSRQMRAASIAAKGEGYGMPAYRVDGNDFEQVYPRLHE
                     AVERARAGGGPTLIEAMTYRMGPHTTSDNPDRYRSREEVEQWRGRDPLTRIQHQMYQRL
                     PNAKTHIENAILAAEKIASEARTSMMQLQMPDPQDLFAHVYANPPATLSAVAEEYAQQH
                     AAQNGENA"
     PFAM_domain     complement(2997..3824)
                     /aSDomain="E1_dh"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00676.22"
                     /description="Dehydrogenase E1 component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_583_0006"
                     /evalue="2.30E-76"
                     /label="ctg1_583"
                     /locus_tag="ctg1_583"
                     /protein_end="302"
                     /protein_start="26"
                     /score="256.7"
                     /tool="antismash"
                     /translation="AMIAGRHFNQQASNLAKQGYMGAYPSSLGQEACQVAAALALEPAD
                     WLFPTYRDSVAVMSRGIDLAEVLSPFHGSSHCGYAPTKTHTAPEATPLATHTAHAVGLA
                     MAAKFAGDSTVALAMCGDGSTSEGDFHEALNLAAVFEAPVVFLVQNNGYAISTPVSRQM
                     RAASIAAKGEGYGMPAYRVDGNDFEQVYPRLHEAVERARAGGGPTLIEAMTYRMGPHTT
                     SDNPDRYRSREEVEQWRGRDPLTRIQHQMYQRLPNAKTHIENAILAAEKIASEA"
     CDS             complement(4029..4982)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 313.4; E-value: 2.5e-95)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_584"
                     /sec_met_domain="fabH (E-value: 8.7e-90, bitscore: 298.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVTISGVGAAVPNDPIPNSEFAALGVDDEWIASRTGVRQRHHLR
                     QEQTLAELALEASEKALADAGISAEEIDFVLAATTTADQVSPGLAPVVAAGLGAPQVGA
                     VDLNAACSGFLYALDYAASKIEQGSIDRALVIGADAMSRLTNPEDAGTAVLFADGAGAA
                     IVQAAPEVSEDEYPYMCSFGSDGSQAQALYISDSTQQVVMDGAEVYMAAVDAMSEEITY
                     VLDSCGIDPERIDQLVCHQANGRIMAAVARRLRWDSSKVLSYIDRYGNTSAASIPITLA
                     IGQQEGHVKPGDLLALTAFGAGFTWGAGVIGFKTTA"
     PFAM_domain     complement(4050..4313)
                     /aSDomain="ACP_syn_III_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08541.12"
                     /description="3-Oxoacyl-[acyl-carrier-protein (ACP)]
                     synthase III C terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_584_0008"
                     /evalue="1.10E-29"
                     /label="ctg1_584"
                     /locus_tag="ctg1_584"
                     /protein_end="311"
                     /protein_start="223"
                     /score="102.5"
                     /tool="antismash"
                     /translation="LDSCGIDPERIDQLVCHQANGRIMAAVARRLRWDSSKVLSYIDRY
                     GNTSAASIPITLAIGQQEGHVKPGDLLALTAFGAGFTWGAGVI"
     aSDomain        complement(4050..4982)
                     /aSDomain="TIGR00747"
                     /aSTool="tigrfam"
                     /description="fabH: 3-oxoacyl-[acyl-carrier-protein]
                     synthase III"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_584_0001"
                     /evalue="3.70E-88"
                     /identifier="TIGR00747"
                     /label="ctg1_584"
                     /locus_tag="ctg1_584"
                     /protein_end="311"
                     /protein_start="0"
                     /score="293.6"
                     /tool="antismash"
                     /translation="MSVTISGVGAAVPNDPIPNSEFAALGVDDEWIASRTGVRQRHHLR
                     QEQTLAELALEASEKALADAGISAEEIDFVLAATTTADQVSPGLAPVVAAGLGAPQVGA
                     VDLNAACSGFLYALDYAASKIEQGSIDRALVIGADAMSRLTNPEDAGTAVLFADGAGAA
                     IVQAAPEVSEDEYPYMCSFGSDGSQAQALYISDSTQQVVMDGAEVYMAAVDAMSEEITY
                     VLDSCGIDPERIDQLVCHQANGRIMAAVARRLRWDSSKVLSYIDRYGNTSAASIPITLA
                     IGQQEGHVKPGDLLALTAFGAGFTWGAGVI"
     PFAM_domain     complement(4473..4667)
                     /aSDomain="ACP_syn_III"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08545.12"
                     /description="3-Oxoacyl-[acyl-carrier-protein (ACP)]
                     synthase III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_584_0007"
                     /evalue="1.30E-23"
                     /label="ctg1_584"
                     /locus_tag="ctg1_584"
                     /protein_end="170"
                     /protein_start="105"
                     /score="82.8"
                     /tool="antismash"
                     /translation="DLNAACSGFLYALDYAASKIEQGSIDRALVIGADAMSRLTNPEDA
                     GTAVLFADGAGAAIVQAAPE"
     CDS             complement(5001..6182)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_585"
                     /sec_met_domain="AfsA (E-value: 6.1e-07, bitscore: 26.5,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTRQPPEDAPQAAGRASADPRYAAYLGCAYPPAPGTAPDANLTQ
                     AEKPAAEDPAHDGEYRVFLRYDTRIAPDVSGPVTLSVTDVEYLQDLHRQGIEALGREAL
                     GVKSADHFVLRGAGLRFTPHVLGGDVRSSDTTGANEPIELSLHVPVSTIRRRRGQPCYA
                     ISGAITLWAGDTCLAESDGAALFLTADTFEELRGELGNTAEIQDAASAGGASAEPPKAV
                     RVWGTPYGHVQAAPASLCGVSDASQVLIGDVHHDDTTHGTENAQEQAEESQVSTSERSP
                     QNPPGAPVLAQCRIVPTAPPRHFDRPLDHYPGLMMASAARQFAVAALAHRTGADPAGLR
                     VAEESHEFFEFVELTEIPTLNLLRCEKHRDTYQIEITVNQGGAVKARSRFTFM"
     PFAM_domain     complement(5007..5300)
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_585_0009"
                     /evalue="4.00E-07"
                     /label="ctg1_585"
                     /locus_tag="ctg1_585"
                     /protein_end="392"
                     /protein_start="294"
                     /score="30.1"
                     /tool="antismash"
                     /translation="IVPTAPPRHFDRPLDHYPGLMMASAARQFAVAALAHRTGADPAGL
                     RVAEESHEFFEFVELTEIPTLNLLRCEKHRDTYQIEITVNQGGAVKARSRFTF"
     CDS             complement(6179..7420)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (49-411). E-value:
                     5.5e-63. Score: 205.1. Matches aSDomain:
                     nrpspksdomains_ctg1_586_PKS_KS.1"
                     /NRPS_PKS="type: PKS/NRPS-like protein"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 327.6; E-value:
                     2e-99)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_586"
                     /sec_met_domain="t2fas (E-value: 4.5e-122, bitscore: 404.7,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSTRVVITGIGAVTPLGVGAETLHERAVAGLSGLNDENENGLGGK
                     VGRCLDFDVKNPLSRREMRRMDRYTQLAVAAADEAIAQAGWGGGLPCDARRITCYIGTA
                     IGGLDTLETQHLVMHTEGAEEVSPLTVPMMMANAAPAHISMRHGLHGETTAIVTACSSG
                     AQAIVAGVRSILLGEADAAVVGGAEAGTTRFTRAIFNAAGAISPDGNSTPFDEERNGFN
                     LGEGAGILVLESAENARARGAEILGEIAGYGLSSDAHHITAPNPDGMYAAYALNRALET
                     AGATPEQVSYVNAHGTGTELNDTTEVNVLRQALGDALENIPVSSTKSAIGHLFGAAGAV
                     ETIATLQALRHGQAPPTLGLKNLDKRLGRVRISGEPQDLAPGTVSAEDGTPKRLGLSNS
                     LGFGGHNVTLAIRA"
     aSDomain        complement(6188..7273)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_586_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="5.50E-63"
                     /label="ctg1_586_PKS_KS.1"
                     /locus_tag="ctg1_586"
                     /protein_end="411"
                     /protein_start="49"
                     /score="205.1"
                     /tool="antismash"
                     /translation="LDFDVKNPLSRREMRRMDRYTQLAVAAADEAIAQAGWGGGLPCDA
                     RRITCYIGTAIGGLDTLETQHLVMHTEGAEEVSPLTVPMMMANAAPAHISMRHGLHGET
                     TAIVTACSSGAQAIVAGVRSILLGEADAAVVGGAEAGTTRFTRAIFNAAGAISPDGNST
                     PFDEERNGFNLGEGAGILVLESAENARARGAEILGEIAGYGLSSDAHHITAPNPDGMYA
                     AYALNRALETAGATPEQVSYVNAHGTGTELNDTTEVNVLRQALGDALENIPVSSTKSAI
                     GHLFGAAGAVETIATLQALRHGQAPPTLGLKNLDKRLGRVRISGEPQDLAPGTVSAEDG
                     TPKRLGLSNSLGFGGHNVTLAI"
     PFAM_domain     complement(6341..6685)
                     /aSDomain="Ketoacyl-synt_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02801.24"
                     /description="Beta-ketoacyl synthase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_586_0011"
                     /evalue="2.00E-36"
                     /label="ctg1_586"
                     /locus_tag="ctg1_586"
                     /protein_end="360"
                     /protein_start="245"
                     /score="124.7"
                     /tool="antismash"
                     /translation="LGEIAGYGLSSDAHHITAPNPDGMYAAYALNRALETAGATPEQVS
                     YVNAHGTGTELNDTTEVNVLRQALGDALENIPVSSTKSAIGHLFGAAGAVETIATLQAL
                     RHGQAPPTLGL"
     CDS_motif       complement(6503..6550)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_586_0001"
                     /evalue="3.40E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="ctg1_586"
                     /protein_end="306"
                     /protein_start="290"
                     /score="10.1"
                     /tool="antismash"
                     /translation="YVNAHGTGTELNDTTE"
     PFAM_domain     complement(6707..7414)
                     /aSDomain="ketoacyl-synt"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00109.28"
                     /description="Beta-ketoacyl synthase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_586_0010"
                     /evalue="1.30E-45"
                     /label="ctg1_586"
                     /locus_tag="ctg1_586"
                     /protein_end="238"
                     /protein_start="2"
                     /score="156.1"
                     /tool="antismash"
                     /translation="TRVVITGIGAVTPLGVGAETLHERAVAGLSGLNDENENGLGGKVG
                     RCLDFDVKNPLSRREMRRMDRYTQLAVAAADEAIAQAGWGGGLPCDARRITCYIGTAIG
                     GLDTLETQHLVMHTEGAEEVSPLTVPMMMANAAPAHISMRHGLHGETTAIVTACSSGAQ
                     AIVAGVRSILLGEADAAVVGGAEAGTTRFTRAIFNAAGAISPDGNSTPFDEERNGFNLG
                     EGAGILVLESAENA"
     CDS             complement(7417..7674)
                     /NRPS_PKS="Domain: PP-binding (22-76). E-value: 7.6e-11.
                     Score: 34.3. Matches aSDomain:
                     nrpspksdomains_ctg1_587_PP-binding.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_587"
                     /sec_met_domain="PP-binding (E-value: 3e-09, bitscore:
                     34.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETPVNTASLEEFVTQQVIDMGVPASTVKLDAKIDSMGLDSLDV
                     VELTQAVKKQLMIPVKPKDFENAATLQDAVDIIREKAQEK"
     aSDomain        complement(7447..7608)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_587_PP-binding.1"
                     /evalue="7.60E-11"
                     /label="ctg1_587_PP-binding.1"
                     /locus_tag="ctg1_587"
                     /protein_end="76"
                     /protein_start="22"
                     /score="34.3"
                     /tool="antismash"
                     /translation="GVPASTVKLDAKIDSMGLDSLDVVELTQAVKKQLMIPVKPKDFEN
                     AATLQDAVD"
     PFAM_domain     complement(7447..7611)
                     /aSDomain="PP-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00550.27"
                     /description="Phosphopantetheine attachment site"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_587_0012"
                     /evalue="8.20E-09"
                     /label="ctg1_587"
                     /locus_tag="ctg1_587"
                     /protein_end="76"
                     /protein_start="21"
                     /score="35.7"
                     /tool="antismash"
                     /translation="MGVPASTVKLDAKIDSMGLDSLDVVELTQAVKKQLMIPVKPKDFE
                     NAATLQDAVD"
     CDS             complement(7791..8555)
                     /NRPS_PKS="Domain: PKS_KR (8-161). E-value: 2e-07. Score:
                     22.9. Matches aSDomain: nrpspksdomains_ctg1_588_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     219.5; E-value: 8.1e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_588"
                     /sec_met_domain="adh_short (E-value: 5.1e-31, bitscore:
                     105.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.5e-33, bitscore:
                     113.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHQKRPGCALVTGASGDIGAQIALRLAQDGWNIAVGYATGIERA
                     EEVAGCIRECGVSAMPIKIDVTSTTSVDDAFDALEDSLGQVTVLVNNAGIRSDGLVAGL
                     SDDEWDAAISTNLSSVFRTSRRALGPMIRARFGRIINISSILAGRTIAGTGSYSAAKSG
                     ILGITRAMAIEVARRGVTVNAVCPGLVETSMTEEVETFTQSVQRAVPMARPAQARDIAE
                     CVAFLASDRADYITGQSIAVDGGLSAQAFSLN"
     PFAM_domain     complement(7815..8516)
                     /aSDomain="adh_short_C2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13561.8"
                     /description="Enoyl-(Acyl carrier protein) reductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_588_0013"
                     /evalue="9.80E-61"
                     /label="ctg1_588"
                     /locus_tag="ctg1_588"
                     /protein_end="247"
                     /protein_start="13"
                     /score="205.4"
                     /tool="antismash"
                     /translation="GASGDIGAQIALRLAQDGWNIAVGYATGIERAEEVAGCIRECGVS
                     AMPIKIDVTSTTSVDDAFDALEDSLGQVTVLVNNAGIRSDGLVAGLSDDEWDAAISTNL
                     SSVFRTSRRALGPMIRARFGRIINISSILAGRTIAGTGSYSAAKSGILGITRAMAIEVA
                     RRGVTVNAVCPGLVETSMTEEVETFTQSVQRAVPMARPAQARDIAECVAFLASDRADYI
                     TGQSIAVDGGLS"
     aSDomain        complement(8073..8531)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_588_PKS_KR.1"
                     /evalue="2.00E-07"
                     /label="ctg1_588_PKS_KR.1"
                     /locus_tag="ctg1_588"
                     /protein_end="161"
                     /protein_start="8"
                     /score="22.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="CALVTGASGDIGAQIALRLAQDGWNIAVGYATGIERAEEVAGCIR
                     ECGVSAMPIKIDVTSTTSVDDAFDALEDSLGQVTVLVNNAGIRSDGLVAGLSDDEWDAA
                     ISTNLSSVFRTSRRALGPMIRARFGRIINISSILAGRTIAGTGSYSAAK"
     CDS_motif       complement(8466..8525)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_588_0001"
                     /evalue="4.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_588"
                     /protein_end="30"
                     /protein_start="10"
                     /score="12.9"
                     /tool="antismash"
                     /translation="LVTGASGDIGAQIALRLAQD"
     CDS             complement(8680..9180)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_589"
                     /sec_met_domain="PF07366 (E-value: 2.8e-29, bitscore: 98.5,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKWGNIIEDMMAQMPEDLRTVALGVAEIFTNMDIETARKYIHPD
                     FVDHEASEGVGGGPEGYLATAKYMNQAFSDASWKPQKIVASADGKHYTMAIKFSGVHTG
                     EFMGVPATGKPFEIHHLHLFRVEDGKAIEHWGGRDELGLLRQIGVLNSEYPTPADAGQA
                     AFA"
     PFAM_domain     complement(8740..9111)
                     /aSDomain="SnoaL"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07366.14"
                     /description="SnoaL-like polyketide cyclase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_589_0014"
                     /evalue="2.50E-28"
                     /label="ctg1_589"
                     /locus_tag="ctg1_589"
                     /protein_end="147"
                     /protein_start="23"
                     /score="98.5"
                     /tool="antismash"
                     /translation="LGVAEIFTNMDIETARKYIHPDFVDHEASEGVGGGPEGYLATAKY
                     MNQAFSDASWKPQKIVASADGKHYTMAIKFSGVHTGEFMGVPATGKPFEIHHLHLFRVE
                     DGKAIEHWGGRDELGLLRQI"
     CDS             complement(9220..9873)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 56.2; E-value: 6.5e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_590"
                     /transl_table=11
                     /translation="MSPNYNTAKYVWTDFGGVLTPPVSHTMRVFCQKYGLTESQLRAGF
                     EAVARNHNLTDPLELVDTPLMSEKEWLSEISEQVGGAFQLDTLADDWFRDREPNASWVA
                     YLHEIKAHGVKVGLISNMVPTWDNHWRAMLNEPDLFDDIVLSFEVGYRKPQRGIYEYAA
                     ELAGVNPAQCILIDDLARNCEGARAAGWDAIEFTTTEECVKQLHPLLSPAEETV"
     PFAM_domain     complement(9292..9564)
                     /aSDomain="HAD_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13419.8"
                     /description="Haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_590_0015"
                     /evalue="1.10E-10"
                     /label="ctg1_590"
                     /locus_tag="ctg1_590"
                     /protein_end="194"
                     /protein_start="103"
                     /score="42.0"
                     /tool="antismash"
                     /translation="AYLHEIKAHGVKVGLISNMVPTWDNHWRAMLNEPDLFDDIVLSFE
                     VGYRKPQRGIYEYAAELAGVNPAQCILIDDLARNCEGARAAGWDAI"
     aSDomain        complement(9292..9570)
                     /aSDomain="TIGR01509"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IA-v3: HAD hydrolase, family IA,
                     variant 3"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_590_0002"
                     /evalue="6.60E-14"
                     /identifier="TIGR01509"
                     /label="ctg1_590"
                     /locus_tag="ctg1_590"
                     /protein_end="194"
                     /protein_start="101"
                     /score="50.3"
                     /tool="antismash"
                     /translation="WVAYLHEIKAHGVKVGLISNMVPTWDNHWRAMLNEPDLFDDIVLS
                     FEVGYRKPQRGIYEYAAELAGVNPAQCILIDDLARNCEGARAAGWDAI"
     aSDomain        complement(9304..9543)
                     /aSDomain="TIGR01549"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IA-v1: HAD hydrolase, family IA,
                     variant 1"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_590_0003"
                     /evalue="7.40E-06"
                     /identifier="TIGR01549"
                     /label="ctg1_590"
                     /locus_tag="ctg1_590"
                     /protein_end="190"
                     /protein_start="110"
                     /score="24.4"
                     /tool="antismash"
                     /translation="AHGVKVGLISNMVPTWDNHWRAMLNEPDLFDDIVLSFEVGYRKPQ
                     RGIYEYAAELAGVNPAQCILIDDLARNCEGARAAG"
     CDS             complement(9889..10863)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_591"
                     /sec_met_domain="AfsA (E-value: 3.3e-15, bitscore: 53.0,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLIYESAPELDETITIDPDIENLHYDRTVDRHKVHRAAVSEVFL
                     TDIRQQSAQHVLVAAQLPSSHSFFHDSIYNDAEGTPDALLLLEIARQATIASAHEVGVD
                     AGNTLISNEFGLTIYPHEIAALNPEDTNLLIRNYFDWTSIRRGAPRSGRCYQQLIMGNR
                     VIAEHFSGGRILTKNQLQALRSEYRGTPPPTTANLHELTFTDVQDPIAPERVGRRNPLN
                     VVISQLNTTETPSAQVTPNVANKALFDHAYDHITMQILTEAARQLYLATRSDSERAPEI
                     SSIRGNFLAFAELDSPVQIRATAPGEFVVEQDNRQIADFALKS"
     PFAM_domain     complement(9955..10221)
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_591_0017"
                     /evalue="2.20E-10"
                     /label="ctg1_591"
                     /locus_tag="ctg1_591"
                     /protein_end="303"
                     /protein_start="214"
                     /score="40.7"
                     /tool="antismash"
                     /translation="VGRRNPLNVVISQLNTTETPSAQVTPNVANKALFDHAYDHITMQI
                     LTEAARQLYLATRSDSERAPEISSIRGNFLAFAELDSPVQIRAT"
     PFAM_domain     complement(10363..10761)
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_591_0016"
                     /evalue="1.30E-15"
                     /label="ctg1_591"
                     /locus_tag="ctg1_591"
                     /protein_end="167"
                     /protein_start="34"
                     /score="57.6"
                     /tool="antismash"
                     /translation="VHRAAVSEVFLTDIRQQSAQHVLVAAQLPSSHSFFHDSIYNDAEG
                     TPDALLLLEIARQATIASAHEVGVDAGNTLISNEFGLTIYPHEIAALNPEDTNLLIRNY
                     FDWTSIRRGAPRSGRCYQQLIMGNRVIAE"
     CDS             11097..11408
                     /locus_tag="ctg1_592"
                     /transl_table=11
                     /translation="MRAAKDRKRSACLSRHIPGGAPLPVRLGQRGSECRKASSAQAAHR
                     IVRYLASVMNSADFVGVHSVHSFFIPTVWVGDTIGTFRKFELGSDGCLWLVEKYVQLA"
     CDS             complement(11405..12820)
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 345.7; E-value:
                     5e-105)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_593"
                     /transl_table=11
                     /translation="MSVTTPHPKRWAILGFMCLALVVTGLDSLIVAVAIPSMETGLQAT
                     GEQLQWVVAAYSLAFAAPLLFFGGLADRIGHKLSFLAGMFILLLGSILAAFSINAEVLI
                     FSRVIMGLGSAFIMPSTLALIRDIFPDHERAKALGIWVGMSSLGIPLGPIVGGLLLKSF
                     SWGSIFLVNVPIIAVAFLACLMLAPESSKKHSSRLDFFGLILSIFGPALLVYGIIAAPE
                     AGWTSSLTLTLLIAGVVLSLIFIVWEHRSASPMLSHEVFRNRRFGGPLLTISSVFFGVF
                     GGLFIMTQHLQFVLGLDPFISGLHMLAMCSAVLVAPISPKLVEKFGLGPVSATGPLMVA
                     LGMVLLAISPSPKSGQVMVALFTFGLGVGFGAPASVNSIIESTPKKQTGAGSAVADVAM
                     QLGGALGIALMGSIGIATATAQSPRGVAAACWVGAAVGLLGAVAVFTVLPKTGEPAVER
                     AVAPEPEPAAKLP"
     aSDomain        complement(11582..12778)
                     /aSDomain="TIGR00711"
                     /aSTool="tigrfam"
                     /description="efflux_EmrB: drug resistance MFS transporter,
                     drug:H+ antiporter-2 (14 Spanner) (DHA2) family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_593_0004"
                     /evalue="7.60E-69"
                     /identifier="TIGR00711"
                     /label="ctg1_593"
                     /locus_tag="ctg1_593"
                     /protein_end="413"
                     /protein_start="14"
                     /score="230.6"
                     /tool="antismash"
                     /translation="GFMCLALVVTGLDSLIVAVAIPSMETGLQATGEQLQWVVAAYSLA
                     FAAPLLFFGGLADRIGHKLSFLAGMFILLLGSILAAFSINAEVLIFSRVIMGLGSAFIM
                     PSTLALIRDIFPDHERAKALGIWVGMSSLGIPLGPIVGGLLLKSFSWGSIFLVNVPIIA
                     VAFLACLMLAPESSKKHSSRLDFFGLILSIFGPALLVYGIIAAPEAGWTSSLTLTLLIA
                     GVVLSLIFIVWEHRSASPMLSHEVFRNRRFGGPLLTISSVFFGVFGGLFIMTQHLQFVL
                     GLDPFISGLHMLAMCSAVLVAPISPKLVEKFGLGPVSATGPLMVALGMVLLAISPSPKS
                     GQVMVALFTFGLGVGFGAPASVNSIIESTPKKQTGAGSAVADVAMQLGGALGIALMGSI
                     "
     PFAM_domain     complement(11603..12769)
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_593_0018"
                     /evalue="3.80E-49"
                     /label="ctg1_593"
                     /locus_tag="ctg1_593"
                     /protein_end="406"
                     /protein_start="17"
                     /score="167.6"
                     /tool="antismash"
                     /translation="CLALVVTGLDSLIVAVAIPSMETGLQATGEQLQWVVAAYSLAFAA
                     PLLFFGGLADRIGHKLSFLAGMFILLLGSILAAFSINAEVLIFSRVIMGLGSAFIMPST
                     LALIRDIFPDHERAKALGIWVGMSSLGIPLGPIVGGLLLKSFSWGSIFLVNVPIIAVAF
                     LACLMLAPESSKKHSSRLDFFGLILSIFGPALLVYGIIAAPEAGWTSSLTLTLLIAGVV
                     LSLIFIVWEHRSASPMLSHEVFRNRRFGGPLLTISSVFFGVFGGLFIMTQHLQFVLGLD
                     PFISGLHMLAMCSAVLVAPISPKLVEKFGLGPVSATGPLMVALGMVLLAISPSPKSGQV
                     MVALFTFGLGVGFGAPASVNSIIESTPKKQTGAGSAVADVAMQLGGALG"
     CDS             complement(13979..14338)
                     /locus_tag="ctg1_594"
                     /transl_table=11
                     /translation="MTTKQTILDYFASIHAGNWQDYISDTMAYGFNTTEQKLNKDEYFQ
                     SAGSFYDATTKVELSQIITEGDKAAVIACYTAQSPAGATRIFEVPEFFTVKDGKIVAST
                     IFFDGPAFMAFMKDE"
     CDS             complement(15081..15548)
                     /locus_tag="ctg1_595"
                     /transl_table=11
                     /translation="MHQISPDGIAFLEEKEGFRSDAYYDVAGVLTIGYGHSTRAPSIEQ
                     YPVYEGQHITEEEGEEILRADLKPTEAAVNSAVTREITQKQYDALVSFTFNLGAGTFKS
                     SDVLELTNKGNYQAAGDAMLQYSHAGGEFIPGLYKRREEERAMYLSSLPQA"
     PFAM_domain     complement(15123..15461)
                     /aSDomain="Phage_lysozyme"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00959.21"
                     /description="Phage lysozyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_595_0019"
                     /evalue="1.20E-13"
                     /label="ctg1_595"
                     /locus_tag="ctg1_595"
                     /protein_end="142"
                     /protein_start="29"
                     /score="51.5"
                     /tool="antismash"
                     /translation="LTIGYGHSTRAPSIEQYPVYEGQHITEEEGEEILRADLKPTEAAV
                     NSAVTREITQKQYDALVSFTFNLGAGTFKSSDVLELTNKGNYQAAGDAMLQYSHAGGEF
                     IPGLYKRRE"
ORIGIN
        1 ccagcataga cttggcggca cgcaccgtat gagaggccga accggcaatc tgctccgcga
       61 gctgttcggc gcatgcattc agctcacccg gctctgacac ccgatgtacc agcgaaagct
      121 cctgcgcacg cgcggcacgc agaatcggct gagtgtataa cagctcggtg gcggcgctga
      181 acccggcgta gcgcggtaag aaccagctca tcccgccgtc cgtggaggcc ccaatcatac
      241 cgtaggcaat attgagtttg gtgcgcggtt cggccacgcg cagatcgcat gcgagcgcta
      301 aggacatgcc cgcccccgcc gcctgcccgt taatggcggc gataaagggg atgggcgcgg
      361 caacgatccc tagaataatg tcttcgagca ggcgcgcgag ttcgcggctg tacgctaagg
      421 attcttcttt ttcgcgcgac atgccttcgg cgaagtcgtc gtagctgccg cctaggctga
      481 agtcctgccc ggctccggtg agcacggcag ctttgagcgt gtcgtcctcg tgcagccggt
      541 tgagcacctc gcgcagttcg gtcgccaggt ggcggctgag ggtgttgcgg ttttcgggct
      601 gattcagggt cacatatgcg atgctgccgc ggcgttcgag gagtacggcg gggttatctg
      661 cggtgttgtt agtcatgaag taccatccga actgtggctg ttgtggcggg tttgctctgg
      721 cctttaacat gcacggcaac acgaatttcg gcgagggtgg catccccaaa gtcttcggcg
      781 ctcacgattg atgcgctgcc gcatacctgc gagtccaccg gcacggcgct gcggaacctg
      841 gcggcactca ccccggcgtt cacgagcata gaggtgccct ctgcggggag cagctgcccg
      901 gcgaaggtga tggcgaggct cagcagatac gctccgtgca cgatggtgcc gccgaagggg
      961 gtgtgcgccg cgcggtacgg gtctgtgtga atccactggg tgtcgccggt gagctcgccg
     1021 aagcggttga tgttttgctg gctgatgcgc atccaggggg tttcacccag gggttcgccg
     1081 atgcgcgcgc tcaggtcggc ggtgcgttcc gcggtcatga tgcgcctccg gcggcttgat
     1141 cggcggcagt ttgtacgtct tcgggggtga tagcgccgcc tgcgccggtt ccggtgacag
     1201 ttttcagatc gaccccgagg gagcgggcga gcctgcgcac ggcgggcgaa actttggcac
     1261 ccgaacgggc cttgccgcct tgagttttgg cggattttgg cggcagcgcg gtaccggtgc
     1321 cgcctggttt gatgggcatt ttgcccctgc ctaccaggtg tttgctctct cctgcgccgg
     1381 gtttggcggg gagcttgtcg gctgaatcct tcgcgggggt ttctgcacca gccgtgggcg
     1441 cctgggcctg cggggtgggg gtgcgcagct cgatgagggg cgcatccacg tcgacaacct
     1501 gaccgaccgg ttcgagcaga cgcaccacgg tgcctgcgac cggcgagggg atttcgaccg
     1561 tggatttagc ggtttcgacc actacgagca cctgatccag ttcaacctgc tgcccttcgc
     1621 tgatgagcca ctcgataatc tcgcccgagc gaagcccctc ccccaaatcc ggcaggtaaa
     1681 aggtgaaggg atagccggaa gcgtcggagc cctcgggcgg taagggatcg gggctcgggg
     1741 cggatgaagc gttcggtgta tcagtcatgc gtgtttctcc tagtcattct cggcgtagag
     1801 ggttgcgata gcgcccagaa tcttctcttc attcggcaaa tacaggtgtt ccagcccggg
     1861 tggcggatag ggcacgtcca gaccggtcac gcgctctacg gggcgttcta agtagtcgaa
     1921 acagcgtgag gtaatgcgcg ccaccacctc ggcgccgaat ccgccggtct gcggggcctc
     1981 gtgtaccatg acggcgcggc cggtgcgcat cacgctttcg catacggtgt gttcgtcgaa
     2041 cggggtgagg gtgcgcaggt cgatcacctc aacgctgtac ccgtattcgg cggcggtttc
     2101 ggcggcggca agcgccattg gtaccgtcgg cccgtagcta atgagggtta cgtcctcgcc
     2161 ggggcggcaa attcgtgcct gcccaatcgg cagaggatcc gccgaggtat caaggtcgcc
     2221 ctcttcccag tacagacgct taggttcgta gaaaatcacc gggtcgtcgc tgcgaatcgc
     2281 ctggcgcagc atatggtagg catccgaagg gttcgagggg gtgtacacgt gcagcccggg
     2341 ggtatgcgca gcgtacccct ccgaactgtc gctgtgatgc tccacggcac ccaccccgcc
     2401 gccgtagggc atgcgcacca ctacgggcat ggaaaggtcg ccgcgcgtgc ggttgcgcat
     2461 tttcgccagg ttgctcacca tctgttcaaa ggcggggtac ccgaaagcgt caaactgcat
     2521 ctcgatcacg gggcggaacc cgtacatcgc catgccgatc gcggccccca taatccctgc
     2581 ctcagaaatg ggggtgtcga agcagcgttc ctcgccaaac cgttcggtca gcccgtcggt
     2641 cacacggaaa acaccgccga gggtgcctac gtccacgccg aacatcacca cgcggtcgtt
     2701 atgctgcatt tcgtggccca aggccaggtt gagggcgcct accattgagg ttcgctgcac
     2761 cgcatccgag cgggattggg tcgattccgg cgcctgaggt gcggtgtcgg atgcggtctt
     2821 cgcgccgcgt acctgagtat ctgctgcctg ctggctcatg cgttttctcc attctgcgcg
     2881 gcgtgctgtt gtgcgtactc ttcggcgacg gcgctcaggg ttgccggcgg gttcgcatat
     2941 acgtgggcga aaaggtcctg cgggtcgggc atctgcagct gcatcatgct ggtgcgggcc
     3001 tcggaggcga tcttttctgc ggctaagatc gcgttttcga tatgggtctt cgcgttcggc
     3061 aggcgctggt acatctgatg ctgaatgcgg gtgagcgggt cacgcccgcg ccactgctcg
     3121 acttcttcgc ggctgcggta ccgatcgggg ttgtcggaag tcgtatgcgg ccccatgcgg
     3181 taggtcatcg cctcaatcag ggtgggaccg ccaccggcac gggcacgctc cacggcttcg
     3241 tgcagccggg gatacacctg ctcaaaatca ttgccgtcaa cccggtatgc aggcatgccg
     3301 tacccttcac ccttcgcggc gatacttgcc gcgcgcatct gccgggatac gggggttgag
     3361 atggcgtacc cgttattctg cacgaggaag accacaggcg cctcgaagac agcggcgagg
     3421 ttaagcgcct catgaaagtc gccttcgctt gtggaaccgt cgccgcacat cgcgagggct
     3481 accgtggaat caccggcgaa tttcgccgcc atcgccagcc cgaccgcgtg ggcggtgtgc
     3541 gtggcgagcg gggttgcctc cggggcggta tgcgttttcg tgggggcata cccgcagtgt
     3601 gaagacccgt ggaagggcga gaggacttcg gcaaggtcga taccccggct catgacggcg
     3661 accgaatcgc ggtaggtggg gaaaagccag tcggcaggct ctaaggcgag ggcggcagca
     3721 acctggcacg cctcctgccc cagggatgag gggtacgccc ccatatatcc ctgtttggca
     3781 aggttgcttg cctgctgatt gaagtgcctg cccgcgatca tggcggcgtg ggcggtgatg
     3841 agcaggtcat cgctcacgcc gttctgcacc tgctgcggcg gggattgtag tgtgttgggc
     3901 atgttaacgc ctatctgtcg gtcccctcat aaaaggctct ttttatgagg ggtgtgggtg
     3961 gcataaaagt gaaatacggt gacggattct agctgcgcgc aaccgggatg cgccctgacc
     4021 gccagcgctt aggcggtggt tttgaacccg atcacgcccg ctccccaggt gaatcccgcc
     4081 ccgaaggcgg tcagcgccag caagtctccc ggtttcacgt gcccctcctg ctgcccgatg
     4141 gctagagtaa tcgggatgga ggcggcagag gtgttcccgt accggtcgat atatgagagc
     4201 actttggaag aatcccagcg cagccgccgc gcgaccgccg ccataatcct gccgttggcc
     4261 tggtggcaga ccagctggtc gatcctctcc gggtcaatac cgcacgagtc gagtacgtag
     4321 gtgatttcct cggacatcgc atccaccgcc gccatataga cctcggcgcc gtccatcacc
     4381 acctgctgcg tggagtcaga aatatacagt gcctgcgcct ggctgccgtc ggacccgaac
     4441 gaacacatat aggggtattc gtcctcgctc acctcggggg ccgcctgtac gatagcggcg
     4501 ccggcaccgt cggcgaagag taccgccgtg cccgcatcct cggggttggt caggcgtgac
     4561 attgcatcgg caccgatgac gagcgcccgg tcgatactgc cctgctcgat ttttgaggcg
     4621 gcgtagtcga gggcgtacag gaacccagaa catgcggcgt tcaaatcgac cgcgcccacc
     4681 tgcggggcgc ctaaacctgc ggcgacgacg ggcgcgagcc ccggcgaaac ctggtcggcg
     4741 gttgtggttg cggcaagcac aaagtcgatt tcttcggcgc ttataccggc atccgcaagc
     4801 gccttctcgc tcgcttcaag cgccagctcg gcgagagtct gctcctggcg caggtggtgg
     4861 cgctggcgca ctccggtgcg actggcaatc cattcgtcgt ccacgccgag cgcggcgaat
     4921 tcgctgtttg gaatggggtc attgggcacg gcggcgccaa cgcccgaaat tgtcacactc
     4981 atggtgcctt tcttgaattt ctacataaag gtgaatcggc tgcgtgcctt aacggcaccg
     5041 ccctgattca cggttatctc tatctgatag gtgtcgcggt gtttctcgca ccgcagcagg
     5101 ttgagggttg gaatctcggt gagttccacg aactcgaaaa attcgtggga ttcttccgcc
     5161 acgcgcaggc ctgcgggatc tgccccggta cgatgcgcga gcgccgccac cgcgaactgc
     5221 cgggctgcgc ttgccatcat gagccccgga tagtggtcca gcgggcggtc gaaatgccgt
     5281 ggcggggctg tgggcacgat gcggcattgg gctagtacgg gggctcccgg cgggttctga
     5341 ggggaccgtt ccgaggtgct cacctgcgat tcttccgcct gttcctgagc gttttcggta
     5401 ccgtgggtcg tatcgtcatg gtgcacgtct ccgatcaaaa cctgggatgc gtcgctcacc
     5461 ccgcacagac tcgcgggggc agcttgcacg tgcccgtacg gtgttcccca cacgcgcacg
     5521 gccttcgggg gttcggcgga tgcgcctccg gcggaagccg catcctggat ttctgcggtg
     5581 ttcccgagtt caccgcgcag ttcctcgaag gtatcggcgg tgaggaagag cgccgcgccg
     5641 tcgctttcgg ctaggcaggt atcgcccgcc cagagggtga tcgccccgct gatcgcatag
     5701 cacggctgcc cgcgcctgcg gcggatggtg ctcacgggaa cgtgcaggct cagctcgatc
     5761 ggctcgtttg cgccggttgt gtcggagctg cgaacgtcgc cgcccagaac atgcggggtg
     5821 aacctcagcc ctgcgccgcg aagcacgaaa tggtcggcgg atttcacgcc gagcgcctcg
     5881 cgcccgagcg cctcgatccc ctggcggtgc aggtcttgca ggtattccac atcggtcacg
     5941 ctcagcgtga ccggcccgct cacatcgggg gcgatgcgcg tatcgtaccg caggaacacg
     6001 cggtattctc cgtcgtgcgc cgggtcttcg gcggcgggtt tttccgcttg tgtgaggttc
     6061 gcatcgggtg ccgtgccggg ggcagggggg taggcgcatc cgagatacgc cgcgtatcgc
     6121 gggtctgcgg atgcacgtcc cgccgcctgc ggcgcatcct cgggaggctg ccgggtactc
     6181 atgcgcgtat cgccagggtc acgttgtgcc cgccgaagcc cagggagttt gagagcccca
     6241 gccttttagg cgtgccgtcc tccgcgctga ccgtgccggg tgctaaatcc tgcggttcgc
     6301 cgctgatgcg cacccgcccc agccgcttat ccaggttttt cagccccagg gtgggcggtg
     6361 cctgcccgtg ccgaagcgcc tgaagtgttg cgatggtctc gacggcgcct gcagccccga
     6421 agaggtgccc aatcgccgat ttcgtggagg aaaccgggat gttctcaaga gcatccccga
     6481 gcgcctgccg cagcacgttc acttcggtcg tatcgttcag ctcggttccg gtgccgtggg
     6541 cgttcacgta cgatacctgc tcgggggttg cccccgcggt ttcaagcgcg cggttgaggg
     6601 cataggccgc atacatgccg tccgggttcg gcgccgtaat gtggtgggcg tccgaagaga
     6661 gcccgtagcc tgcaatttcg cccagtatct cggcgccccg ggcgcgggcg ttctcggctg
     6721 attcgagcac gagaataccg gcaccctccc ccaggttgaa gccgttgcgc tcctcatcga
     6781 agggggtcga gttcccgtcg ggcgagatcg ccccggcggc gttgaatata gcgcgggtga
     6841 accgggtggt tcccgcctct gcgccgccta caacggctgc atccgcctcg cccagcagaa
     6901 tactgcgcac accggcgaca atcgcctgcg cccccgagga gcacgccgtg acgattgcgg
     6961 ttgtttcgcc gtgcagcccg tggcgcatcg aaatatgcgc gggcgcggcg ttcgccatca
     7021 tcatgggcac ggtcagcggc gagacttctt cggcgccctc ggtgtgcatc actaaatgct
     7081 gcgtttcgag ggtgtccagc ccgccgatag cggtaccgat atagcaggtg atgcgccgcg
     7141 catcgcacgg cagcccgccg ccccagcccg cctgcgcgat agcctcatcg gccgccgcca
     7201 cggcaagctg ggtgtaccgg tccatgcggc gcatctcgcg gcgactgagc gggttcttca
     7261 cgtcaaagtc gaggcatcgc ccaactttgc cgcccagccc gttctcgttt tcgtcgttca
     7321 gcccgctcag gcccgccacg gcacgctcat gcagcgtctc ggcgccaaca cccagcgggg
     7381 tgacggcacc gattcccgtg atgactactc tcgtactcac ttctcctgtg ccttttcacg
     7441 aataatatct acggcatctt gtagggtggc ggcgttttca aaatccttgg gcttgacggg
     7501 aatcatcagc tgcttcttga ccgcctgggt gagctcaaca acgtctaggg agtcgagccc
     7561 catcgaatcg attttggcat cgagtttaac ggtgctggcg ggcacgccca tgtcgatcac
     7621 ctgctgggtc acgaactctt ccagggatgc ggtgttaacg ggggtctcag tcatggttct
     7681 ctcctgatcg gattatctgg tgtttttctg tggttggtta tcttgtgttc acggcgggta
     7741 cctgtgaact tatccggcaa acggcggact tgcttggggc gagcgcgaac ctagttcagc
     7801 gaaaacgcct gagcgctcag cccgccatct accgcaatgc tctgcccggt aatgtagtcg
     7861 gcgcggtcgc tggcgaggaa cgccacgcac tcggcaatat cgcgtgcctg cgcggggcga
     7921 gccatcggca cggcgcgctg caccgactgg gtgaaggttt caacttcttc ggtcattgag
     7981 gtttcaacga gcccggggca taccgcgttc acggtcaccc cgcggcgcgc cacctcgata
     8041 gccatcgcgc gggttattcc taaaattccg cttttcgcgg cggaatagct gccggttccg
     8101 gcgattgtcc tcccggcaag aatcgaggaa atattgatga ttcgcccaaa acgtgcgcga
     8161 atcatcggcc ccaacgcccg ccgagaggta cgaaaaaccg agcttaagtt cgtcgaaatc
     8221 gccgcatccc attcgtcgtc gctgagcccc gcaaccagcc cgtcggaacg aattccggcg
     8281 ttattgacca gcacggtgac ctgccctaac gagtcttcga gcgcatcaaa agcgtcatca
     8341 actgaggtgg tgctggtgac gtcaattttg atgggcatcg ctgacacacc gcattcgcgg
     8401 atgcacccgg caacctcttc ggcgcgctcg attccggtgg cgtagccgac ggctatattc
     8461 catccgtcct gcgccagtct gagcgcgatt tgtgcgccaa tatctcccga cgctccggtg
     8521 acgagggcgc atcctgggcg cttctggtgt gtcatctgac tccttaggtt tggttcttat
     8581 gctgcggcgg gttcacggcg tatcgcgtgc cgtggtagtt cgccgcgcgg tgctcaatgg
     8641 cgttacgtgg gatgcgtgaa tgcgtgtttc gcccgcgttt taggcgaagg cggcctgccc
     8701 ggcgtctgcg ggggtgggat actcggaatt gagaacaccg atctggcgca gcaggccgag
     8761 ctcatcgcgc ccgccccagt gctcgattgc cttgccgtct tcaacacgga aaaggtgcag
     8821 gtggtgaatc tcgaagggct tgccggtggc gggaacgccc atgaactcgc cggtgtgaac
     8881 gccgctgaac ttgatcgcca tggtgtagtg cttaccgtcc gcacttgcca caatcttctg
     8941 gggcttccac gaggcatcgg agaacgcctg gttcatgtat ttcgcggttg ccaggtaccc
     9001 ttcggggccg ccgccaacgc cttcgctcgc ctcatgatca acgaagtcgg ggtgaatgta
     9061 tttgcgggcg gtttcgatat ccatgttcgt gaaaatctca gccacgccga gggcgacggt
     9121 gcgcaggtct tcgggcatct gcgccatcat gtcttcgata atatttcccc acttgcccat
     9181 gggttttcct ttcgttgggt gaccttccgg tcacggggtt taaactgttt cctctgccgg
     9241 tgagagcagg gggtgcagct gtttcacgca ctcttcggtt gtggtgaatt cgatggcatc
     9301 ccacccggct gcacgggcgc cttcgcagtt acgcgcaagg tcgtcaatga ggatgcactg
     9361 cgccgggttc accccggcaa gttctgcggc gtactcgtag ataccgcgct gcggtttgcg
     9421 gtatccgacc tcgaaggaga gcacaatatc gtcgaaaaga tcgggttcgt tgagcatggc
     9481 gcgccagtgg ttatcccagg tgggcaccat atttgagatc agtcctacct tcacgccgtg
     9541 cgctttgatc tcgtgcaggt acgctaccca ggatgcgttg ggctcgcggt cgcggaacca
     9601 gtcgtcggcg agggtgtcga gctggaacgc cccgccgact tgctcggaaa tttcgctcag
     9661 ccactctttt tcgctcatca ggggcgtatc gacgagttcc agcgggtcgg tgaggttgtg
     9721 gttgcgggcg accgcctcaa atcccgcgcg cagctgggac tcggtgagcc cgtatttctg
     9781 gcagaagacg cgcatcgtat ggctgaccgg cggggtgagt actccgccga agtccgtcca
     9841 cacatatttc gcggtgttgt agttgggcga cataaagatc cttgtcatct agcttttgag
     9901 cgcgaaatcc gcgatctgcc ggttatcttg ttcaaccacg aattccccgg gtgccgttgc
     9961 acggatctgc acgggtgaat cgagttccgc gaacgccagg aagttcccgc gtattgagga
    10021 aatttcgggg gcgcgctcgc tatccgagcg ggttgccagg tagagctgcc gtgccgcctc
    10081 ggtcaaaatt tgcatggtga tgtggtcgta ggcgtggtcg aaaagtgcct tattcgccac
    10141 gttcggggtc acctgcgcac tcggggtttc ggtggtgttc agctgcgaga tcaccacgtt
    10201 gagggggttg cgcctgccca cacgctcggg ggcgatggga tcctgcacgt ctgtgaaggt
    10261 tagctcgtgc aggttcgcgg tcgtgggcgg cggggtgccg cggtattcgc tgcgcagcgc
    10321 ctgcaattgg tttttggtga ggatgcgccc gccgctgaag tgctcggcga tcacccggtt
    10381 gcccataatg agctgctggt agcaccgacc ggagcgcggg gcgccacgcc gaatggaggt
    10441 ccagtcgaag tagttgcgaa tcagcaggtt ggtatcttcg gggtttagcg cggcgatttc
    10501 gtgcggataa atcgtgagcc caaactcgtt ggagatcagg gtgtttccgg cgtctacacc
    10561 gacttcgtgg gcgctggcga ttgtcgcctg ccgcgcaatt tcgagcagca ggagcgcatc
    10621 gggggttcct tcggcatcgt tgtagatgct gtcgtgaaag aagctgtgcg atgagggcag
    10681 ctgcgccgcc acgagcacat gctgcgcgct ctgctggcga atatctgtga ggaaaacttc
    10741 ggaaaccgct gcacggtgta ccttatggcg atcgacggta cggtcatagt gcagattttc
    10801 tatatccggg tctatcgtga tagtttcgtc gagctctggt gccgactcgt atatgagggt
    10861 catatgccct cctcctttgg ctgtggttgg tgtatgttgc acgtggttac ggggtcccgt
    10921 ggggcttacc gcgtgcgggt gagtaagctc cttgggtgtg cgttatcggt gttgttatgc
    10981 cctgccgctg gatacgggta atatggtgaa gattctcaat atcaaaaaga tataagtacg
    11041 gtcactgtgg tgcgaaggtg tgatgatccc ttgatattcc tgcggattca cgatggatgc
    11101 gggctgcgaa agaccgaaag cgcagcgctt gtctatcccg gcatatacct gggggtgcac
    11161 cgctgcccgt gaggttgggt cagcgaggat ctgagtgtcg gaaggcttcg agtgctcagg
    11221 cagcgcaccg catcgtgcgt tatctggcgt ctgttatgaa ttctgctgat ttcgtcggtg
    11281 ttcatagcgt tcattccttt ttcatcccta ccgtgtgggt aggagatacc atcggaacgt
    11341 ttcggaagtt tgagttaggt tctgatggtt gtctgtggtt ggttgaaaaa tatgtgcagc
    11401 tggcctaagg cagcttagct gcgggttctg gttctggcgc gaccgctcgt tcgacggcgg
    11461 gttcgccagt tttgggaagc acggtgaaga cggcaacagc acccaaaaga cctactgccg
    11521 cgcctaccca gcacgcagcg gctacgcctc ggggcgattg tgccgttgcg gtggcgattc
    11581 ctatacttcc catcagcgcg atacccaggg cgccgccgag ctgcatagca acatcggcaa
    11641 ccgccgagcc cgcgccggtt tgtttcttgg gggtcgattc aatgatcgag ttcacggagg
    11701 ccggggcgcc aaaacccaca cccagcccga acgtgaagag cgctaccata acctgcccgc
    11761 tcttgggcga gggactgata gccagaagca ccatgccgag ggcgaccatg agagggccgg
    11821 tggctgagac gggacccagc ccgaactttt cgacgagttt gggcgagatc ggtgccacga
    11881 gaaccgccga acacatggcg agcatatgca gaccggaaat aaaagggtca agccctagga
    11941 cgaactgcaa atgctgagtc atgatgaaca gcccgccgaa gaccccgaaa aataccgaag
    12001 agatcgtcag cagcggtccg ccgaaccggc ggttacggaa gacctcatgg ctgagcatgg
    12061 gcgatgcgct gcggtgctcc cacacgatga agatcaggct cagcaccaca cccgcaatca
    12121 gcagggtcag cgtcaagctt gaggtccagc ctgcttccgg ggcggcgata atgccgtaca
    12181 ccagcagggc aggcccgaag atcgagagga tcagcccgaa gaagtccagg cgggaagagt
    12241 gcttttttga ggattccggg gcgagcatca ggcatgccag aaatgccacg gcaataatag
    12301 gcacgttgac caggaaaatt gatccccacg aaaaactttt gagcagcagt ccgcccacaa
    12361 taggaccgag cggaataccc agcgaggaca ttcctaccca aattccgaga gctttagcac
    12421 gttcatggtc tggaaaaata tcacgaataa gtgctagggt cgaaggcata ataaatgctg
    12481 atccgagacc cataattact cgtgaaaaaa taagtacttc tgcattaata gagaaagccg
    12541 ccagtattga accaagcagc aaaataaaca taccggctag aaaacttagt ttatgtccga
    12601 ttctgtcggc aagaccgcca aagaaaagca gcggtgcggc aaatgcaagt gaataggctg
    12661 caacaaccca ttgcaattgt tcgcccgttg cctgtagtcc agtctccata gacggtatag
    12721 cgaccgcaac aatgagcgaa tccagcccgg tcacaaccag cgctaggcac ataaacccga
    12781 ggattgccca gcgcttgggg tggggtgtag tcacgctcat ttttggtcct tgaagtggtt
    12841 ggaagacata gctatatgta acagtgatgt ctcaagtata cagttcaaat ttggtctgtc
    12901 aatcgtttat tttcactatt tacacgtcaa ttatttatat atatttattg ccgcccaaga
    12961 aacaaaatta gtgtcgctgt aaattattaa aagaattgag agagtgaaga tttaattttt
    13021 atattttcct tgtaaatact ttcatcaaat ttccccggta attatcgcat aaacctaccg
    13081 cgttgtgttg agcgcatagc ataatcccgt cccgttcacc acggtccgtt cgctgtctgc
    13141 agcgaaggcg agcacacgac gagaacccct tgtgtgggat gcgttacgcc ccaaaatttt
    13201 cggtgccaac atgcgaacgg gtcggtttca ccaaaaatta tgggaaaacc gacccgcccg
    13261 cgtgtcgtat cgaattctga ggaagatcag gtcgcaaagc cgagctgata tacagcaaag
    13321 acgtagccct tagttacagc ctagtaactc agtcctccgg gaacctcgta gtcttgtaga
    13381 gcgtatctgt cagaccagat cccgcatgat ccgatcgtcc cgctgccgcc ctcaatgacc
    13441 accgggcgat ggttggtgta tagcggttca ggtgcttgtc ggtcttggtg agcccccccc
    13501 cgaagtcttc agctcaaact tcttcggtgt ggctttacct cagatacagc agggtgactt
    13561 taaagccttg gtgagggtga gcttataggt ttagttctca gccaatccaa ccctatgctc
    13621 gtcagggagg ctaagagggt aaccaattgt aggcggttac tccggtggta cggtaaggag
    13681 gcaacggttt ctcctagggc atgttgatgg gttagttggt tttataggat ccatcatacg
    13741 tcggctaatg aggagccgtt tgtttttcat gtgtggttag aggtgctgac tagccttata
    13801 aataacgctc tttgaacagt ggagaacagt gcatgtcgga gtatgtataa tcaacattat
    13861 aaatattaaa atacaaaagt aggctactcc tacctaaaag acttaggtgg agataaccta
    13921 cttttcaaaa atatttaatt tatattaata ctatatgaag cacctgaata taaattaatt
    13981 attcatcctt catgaaggcc ataaatgcag gaccatcaaa gaaaatggtc gacgctacaa
    14041 ttttaccatc ttttacggta aaaaattcag gaacctcaaa aattcgcgtg gcaccggcag
    14101 gagattgcgc ggtgtaacat gctatgacgg ctgctttgtc tccttcggta ataatctgag
    14161 aaagctcaac ttttgtggta gcatcataga aacttcccgc actttgaaag tattcgtctt
    14221 tattgagttt ttgctctgta gtgttaaagc cgtaggccat agtatcacta atgtaatcct
    14281 gccagtttcc ggcatggata gatgcaaaat aatccaaaat ggtctgcttg gtagtcattc
    14341 gtttagtctc ctcactaaaa tgtaaccgaa aagatgtggt gtgggcaacc cacccactta
    14401 accataacag atatattccc gttattaggg taataactac atatataatt cgcctaaacc
    14461 tttatgcacc taaatccggt gcactttgcg gcgatcgacc gtacggtcat aggcaagatc
    14521 ctctgcagca taatcgatag ataaagctgt cggctataag tgcttgatcc aggacttctg
    14581 cggtggggtg agagagccac gaacgctgtc ggctaatccg ccgaagaaaa gcagcggtgc
    14641 cgcgaaggcg agcgaatacg ccgccacaaa tcattgcagc tgctcaccgg tggtctgcac
    14701 ccctacctcc ccatcgaggg gatggtgacc gcgacaatca gggaatctag gcccgtcacc
    14761 acgagcgcaa ggcacataaa tccaaggatt gcccagcgtt tgggatgcat tacgccccaa
    14821 aattttcggt gtgcccgcct gctatgcacc acaaaacggg ggagaaacag accgaagtct
    14881 gttcctcccc cgctagaatc tatgggctca tagtgagtgt ttctggaacc tcgtagtctt
    14941 gtagagcgta tctgtcagac cagatcacgc actacctatt ctgagtagcc agtcagggtc
    15001 tccaccgatt cggaagcttt agagcttttc cccaagaacc cgtcatgata accgaccccg
    15061 acatcgtacc gcactgaatc ttatgcttgg ggaagcgaag aaagatacat agccctttcc
    15121 tcctccctgc gcttgtacag ccccgggatg aattctccgc cagcgtgcga gtattgcagc
    15181 atagcatccc cggcggcctg ataatttccc ttgttcgtga gttcgagaac atcactcgac
    15241 ttaaaggtac ccgcgcccag gttgaaggtg aatgacacga gcgcatcgta ttgcttctga
    15301 gtaatttcac gagtaacagc agaattcaca gcagcttcgg taggcttcaa atctgcgcga
    15361 aggatctcct ccccttcctc ttcggtgata tgctgcccct cataaacggg gtattgctca
    15421 atactgggcg cacgggtcga atgcccgtaa ccaatcgtga gaacgcccgc cacgtcgtag
    15481 taggcgtcac tcctgaaccc ttctttctct tccaagaagg caattccgtc aggtgatatc
    15541 tgatgcattg gtatcaactc ctctgaagaa taattacgat ttcattaaga ggttccggtc
    15601 cccaccgtaa ctaaggattc agagtcatac aagaggtata acagacagtc ttctgccttg
    15661 acgctcgaac tcgcagttgt gccagagtgt gtttttaatc aaactccccg ctggcgatta
    15721 actgttcacg taccttgcgg cgcagaatct tgccgagcat cgaccggggc agatcgtcca
    15781 ccgccacaat cttgcgcggc accttatagc gggtcacgcg cgcatagcag tgctcgcgca
    15841 gcgcatgttc atcaaccgcg tgt
//
