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Overview
1.1
2.1
2.2
4.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_KB905472.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | RRE-containing | 2,127,823 | 2,148,140 |

NZ_KB905473.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS | 222,346 | 268,510 |
Region 2.2 | resorcinol | 271,683 | 312,822 |

NZ_KB905475.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | RiPP-like | 134,495 | 146,663 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | RRE-containing | 2,127,823 | 2,148,140 |
Region 2.1 | NRPS | 222,346 | 268,510 |
Region 2.2 | resorcinol | 271,683 | 312,822 |
Region 4.1 | RiPP-like | 134,495 | 146,663 |

No secondary metabolite regions were found in these records:
  NZ_KB905474.1
  NZ_KB905476.1
  NZ_KB905477.1
  NZ_KB905478.1
  NZ_KB905479.1
  NZ_KB905480.1
  NZ_KB905481.1
  NZ_KB905482.1
  NZ_KB905483.1
  NZ_KB905484.1
  NZ_KB905485.1
  NZ_KB905486.1

Compact view
NZ_KB905472.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,127,823 - 2,148,140 nt. (total: 20,318 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001551.1 |  | 0.25 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001588.1 |  | 0.17 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0001589.1 |  | 0.17 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0001496.1 |  | 0.17 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001550.1 |  | 0.16 | RiPP | citrulassin D | Streptomyces katrae
BGC0000486.1 |  | 0.16 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001549.1 |  | 0.16 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0000294.1 |  | 0.16 | NRP | acinetobactin | Acinetobacter baumannii
BGC0001552.1 |  | 0.16 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001176.1 |  | 0.16 | RiPP | streptomonomicin | Streptomonospora alba

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001551.1 |  | 0.58 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001588.1 |  | 0.48 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0001589.1 |  | 0.48 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0001496.1 |  | 0.48 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001550.1 |  | 0.47 | RiPP | citrulassin D | Streptomyces katrae
BGC0000486.1 |  | 0.47 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001549.1 |  | 0.47 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0000294.1 |  | 0.47 | NRP | acinetobactin | Acinetobacter baumannii
BGC0001552.1 |  | 0.47 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001176.1 |  | 0.47 | RiPP | streptomonomicin | Streptomonospora alba

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB905473.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 222,346 - 268,510 nt. (total: 46,165 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.33 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000900.1 |  | 0.31 | Other | ferrichrome | Aspergillus oryzae
BGC0001615.1 |  | 0.31 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001249.1 |  | 0.31 | NRP | dimethylcoprogen | Alternaria alternata
BGC0001479.1 |  | 0.27 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001561.1 |  | 0.27 | NRP | curacomycin | Streptomyces curacoi
BGC0001132.1 |  | 0.26 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000979.1 |  | 0.25 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.25 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001128.1 |  | 0.24 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000900.1 |  | 0.65 | Other | ferrichrome | Aspergillus oryzae
BGC0001615.1 |  | 0.65 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001249.1 |  | 0.65 | NRP | dimethylcoprogen | Alternaria alternata
BGC0001479.1 |  | 0.61 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001561.1 |  | 0.61 | NRP | curacomycin | Streptomyces curacoi
BGC0001132.1 |  | 0.59 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000979.1 |  | 0.58 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.58 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001128.1 |  | 0.58 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 222345 - 268510:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_206: X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (8..447): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DYggsGsLIK
    Nearest Stachelhaus code:
      pip
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1210..1629): X
  NRPSPredictor2: tyr, bht
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DmTnmGEVaK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      60% (weak)

NZ_KB905473.1 - Region 2 - resorcinol
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 271,683 - 312,822 nt. (total: 41,140 nt) Show pHMM detection rules used
resorcinol: DarB

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | resorcinol | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001588.1 |  | 0.16 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0001120.1 |  | 0.15 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001526.1 |  | 0.13 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000043.1 |  | 0.11 | Polyketide | curacin A | Moorea producens 19L
BGC0001525.1 |  | 0.10 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0002026.1 |  | 0.09 | NRP | thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2 | Jahnella sp. MSr9139
BGC0002007.1 |  | 0.07 | Terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0001838.1 |  | 0.07 | NRP | WLIP | Pseudomonas putida
BGC0000838.1 |  | 0.05 | Polyketide | flexirubin | Flavobacterium johnsoniae UW101
BGC0002025.1 |  | 0.05 | NRP | thaxteramide C | Jahnella sp. MSr9139

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001588.1 |  | 0.46 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0001120.1 |  | 0.45 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001526.1 |  | 0.41 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000043.1 |  | 0.37 | Polyketide | curacin A | Moorea producens 19L
BGC0001525.1 |  | 0.37 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0002026.1 |  | 0.33 | NRP | thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2 | Jahnella sp. MSr9139
BGC0002007.1 |  | 0.29 | Terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0001838.1 |  | 0.28 | NRP | WLIP | Pseudomonas putida
BGC0000838.1 |  | 0.24 | Polyketide | flexirubin | Flavobacterium johnsoniae UW101
BGC0002025.1 |  | 0.21 | NRP | thaxteramide C | Jahnella sp. MSr9139

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB905475.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 134,495 - 146,663 nt. (total: 12,169 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.20 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  | 0.19 | RiPP | coagulin | Bacillus coagulans
BGC0000519.1 |  | 0.16 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000551.1 |  | 0.16 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000624.1 |  | 0.16 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001210.1 |  | 0.16 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000513.1 |  | 0.16 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001862.1 |  | 0.16 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.16 | RiPP | pallidocin | Aeribacillus pallidus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.53 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  | 0.51 | RiPP | coagulin | Bacillus coagulans
BGC0000519.1 |  | 0.47 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000501.1 |  | 0.47 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000551.1 |  | 0.47 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000624.1 |  | 0.47 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001210.1 |  | 0.46 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000513.1 |  | 0.46 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001862.1 |  | 0.46 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.46 | RiPP | pallidocin | Aeribacillus pallidus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names