LOCUS       NZ_CP071883.1           7902 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP071883.1 Curtobacterium flaccumfaciens pv. flaccumfaciens
            strain BRIP:70614 chromosome, complete genome.
ACCESSION   NZ_CP071883
VERSION     NZ_CP071883.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:14:27
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 405831
            Orig. end    :: 413733
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..582
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111:GCN5-related N-acetyltransferase (Score: 101;
                     E-value: 1.2e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_396"
                     /transl_table=11
                     /translation="MVHQLLTPSQEIRTDRLLLTPLTPADIDDVHALFSDARTWQHLPT
                     GRHVARSSSVDMVQRKIGGRARHGLGSWAVRSASDHAFVGVGGVDMTAGGVWNLGYRLA
                     PAAWGQGFASEIALAAVRAAADTAPDVPVTGRVLTNNPASAAVLRRAGLSLVWQGAPAP
                     QNRAAAGVEGQVWTDRLLSDEQFAWLVANA"
     protocluster    1..7902
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[409143:409536](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(3313..3705)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..7902
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7902
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     46..459
                     /aSDomain="Acetyltransf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13302.9"
                     /description="Acetyltransferase (GNAT) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_396_0001"
                     /evalue="8.70E-22"
                     /label="ctg1_396"
                     /locus_tag="ctg1_396"
                     /protein_end="153"
                     /protein_start="15"
                     /score="78.4"
                     /tool="antismash"
                     /translation="RLLLTPLTPADIDDVHALFSDARTWQHLPTGRHVARSSSVDMVQR
                     KIGGRARHGLGSWAVRSASDHAFVGVGGVDMTAGGVWNLGYRLAPAAWGQGFASEIALA
                     AVRAAADTAPDVPVTGRVLTNNPASAAVLRRAGL"
     CDS             complement(587..1225)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 182.6; E-value:
                     1.6e-55)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_397"
                     /transl_table=11
                     /translation="MIEVRNASKRRGGRALWHDLSFEVTGGEIVGLVGPSGCGKSTLLD
                     CIGHIDALDDGTIRINGESAGSNGRRARLIRRRHLGYLFQDFGLVPDMTVQSNLDLVRL
                     PDGRRRHRGIRTGEALDRVGLAGRGTDRIHELSGGEQQRVAMARLLVKRPSVILADEPT
                     SALDDDNAAMVLDLLGELAADGAAVLIATHSSSVEARAARSITLGGPAR"
     PFAM_domain     complement(734..1174)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_397_0002"
                     /evalue="5.00E-32"
                     /label="ctg1_397"
                     /locus_tag="ctg1_397"
                     /protein_end="164"
                     /protein_start="17"
                     /score="111.4"
                     /tool="antismash"
                     /translation="HDLSFEVTGGEIVGLVGPSGCGKSTLLDCIGHIDALDDGTIRING
                     ESAGSNGRRARLIRRRHLGYLFQDFGLVPDMTVQSNLDLVRLPDGRRRHRGIRTGEALD
                     RVGLAGRGTDRIHELSGGEQQRVAMARLLVKRPSVILADEPTS"
     CDS             complement(1222..3249)
                     /locus_tag="ctg1_398"
                     /transl_table=11
                     /translation="MNIRSVTLAYLVPPLLASVLGFIGLVQVSEAGIVGASSVVTAAAG
                     AETGSNQRVATALEQVAEAEHATIARVVADREAPTTRRVALVTDAPSSRGAGWLLDGYE
                     DFTRSMVTTVRPMSELDQFDPTGSYSVFGDDDARRAVVTALADAGYEVSVERVPLLQRI
                     GVTDGLDQTLALVGALVSGCVALCLMTTVGAPRRSAVRRLHGDTTAAIVVQELAELRTA
                     VLVTVIGVPVAATGLWFYNGLASAATLAAAISVFCVGLLVPVVVAHTIGTVLACRQPLA
                     GALRGARPAGALLLVAQIARVPTLLLLVAAVFELTGAVTTARQGTAERDLRAAGETVQL
                     WVTPDPRPVEEQAYWDRIGDFAGGALERRDAFLAAAVEVSSGSGKSTVPALVVDQGYLD
                     LQEVRSADGARITTDGAEIAVWMPADSDLSRERLVEGLTEWQLRDAPDALLEHVTGGTL
                     ARQQVYSYPDDASSRAWLDDAVIVVVPTPVDVFSADELGSWLSTGDVVFTSRAAAERSI
                     GASGLRDEFSAVVAVGQSAAEQARRAATTVAIGTGTLVSTLAVSVMLGMVATIAYRRRH
                     GRVLFAKFTSGVSPVRTDAGLLTIEAGLVSIAVIAVVNTWWSQRPDGSGLRSALDPVAQ
                     SAGVAGALALVALAALSATSLVVMAVTARSTARNRGNGSR"
     CDS             complement(3313..3705)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_399"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.8e-11,
                     bitscore: 42.2, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHKSRTKMLVGLGLTVGLITGTATAASAAQFEVMGSGSEAGGVAV
                     AASGASASGETSGIGTDNDGGGGSFWQWGVGKDDTWSNYFREKRCHGATAVGKKSKRVT
                     NVPGGRYAMAMTPKARSGKKAYYHNC"
     aSDomain        complement(3319..3654)
                     /aSDomain="TIGR01653"
                     /aSTool="tigrfam"
                     /description="lactococcin_972: bacteriocin, lactococcin 972
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_399_0001"
                     /evalue="7.30E-10"
                     /identifier="TIGR01653"
                     /label="ctg1_399"
                     /locus_tag="ctg1_399"
                     /protein_end="129"
                     /protein_start="17"
                     /score="37.0"
                     /tool="antismash"
                     /translation="LITGTATAASAAQFEVMGSGSEAGGVAVAASGASASGETSGIGTD
                     NDGGGGSFWQWGVGKDDTWSNYFREKRCHGATAVGKKSKRVTNVPGGRYAMAMTPKARS
                     GKKAYYHN"
     PFAM_domain     complement(3325..3507)
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_399_0003"
                     /evalue="1.50E-11"
                     /label="ctg1_399"
                     /locus_tag="ctg1_399"
                     /protein_end="127"
                     /protein_start="66"
                     /score="44.7"
                     /tool="antismash"
                     /translation="GGSFWQWGVGKDDTWSNYFREKRCHGATAVGKKSKRVTNVPGGRY
                     AMAMTPKARSGKKAYY"
     CDS             3915..4649
                     /gene_functions="regulatory (smcogs) SMCOG1136:GntR family
                     transcriptional regulator (Score: 244; E-value: 2.5e-74)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_400"
                     /transl_table=11
                     /translation="MTSRITEGAEPKHQQLRRILLDLVTTRLAPGAAIPSERQLIAEYG
                     VSRITVREALGQLVNEGYLERVRGKGTFVAHRPVQSTLHLASFTEEMRAMGHEPTTVVL
                     VREERVPPADTAAALRIDPDVPAFHVKRLRMADGAPVSIDDAWLVADAFPGLLDHDLSG
                     SVYSIIATEYGTPIDRAQQTVAANPAADDVATLLGTKTGAPVLEFDRVSYAGERPVEHT
                     RSWYRSDRYRVQMEVTATPAVA"
     PFAM_domain     3966..4136
                     /aSDomain="GntR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00392.23"
                     /description="Bacterial regulatory proteins, gntR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_400_0004"
                     /evalue="2.20E-19"
                     /label="ctg1_400"
                     /locus_tag="ctg1_400"
                     /protein_end="74"
                     /protein_start="17"
                     /score="68.9"
                     /tool="antismash"
                     /translation="RILLDLVTTRLAPGAAIPSERQLIAEYGVSRITVREALGQLVNEG
                     YLERVRGKGTFV"
     PFAM_domain     4194..4610
                     /aSDomain="UTRA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07702.15"
                     /description="UTRA domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_400_0005"
                     /evalue="1.50E-40"
                     /label="ctg1_400"
                     /locus_tag="ctg1_400"
                     /protein_end="232"
                     /protein_start="93"
                     /score="138.4"
                     /tool="antismash"
                     /translation="AMGHEPTTVVLVREERVPPADTAAALRIDPDVPAFHVKRLRMADG
                     APVSIDDAWLVADAFPGLLDHDLSGSVYSIIATEYGTPIDRAQQTVAANPAADDVATLL
                     GTKTGAPVLEFDRVSYAGERPVEHTRSWYRSDRYR"
     CDS             complement(4728..5180)
                     /locus_tag="ctg1_401"
                     /transl_table=11
                     /translation="VTVVRTPFGGPVVALADVPDPVFAGQLVGAGVAVDPTGVEGAITA
                     VAPVDGTIVKLHPHAFALQGAAGTDVLVHVGIDTVKLSGEGFELLATEGDTVTAGDPVV
                     RFTPSVISAAGYSPICPVVVLGSTPDSVDQGTVGTTVLDGDTLFEV"
     PFAM_domain     complement(4806..5171)
                     /aSDomain="PTS_EIIA_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00358.22"
                     /description="phosphoenolpyruvate-dependent sugar
                     phosphotransferase system, EIIA 1"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_401_0006"
                     /evalue="8.60E-39"
                     /label="ctg1_401"
                     /locus_tag="ctg1_401"
                     /protein_end="125"
                     /protein_start="3"
                     /score="132.3"
                     /tool="antismash"
                     /translation="VRTPFGGPVVALADVPDPVFAGQLVGAGVAVDPTGVEGAITAVAP
                     VDGTIVKLHPHAFALQGAAGTDVLVHVGIDTVKLSGEGFELLATEGDTVTAGDPVVRFT
                     PSVISAAGYSPICPVVVL"
     aSDomain        complement(4809..5165)
                     /aSDomain="TIGR00830"
                     /aSTool="tigrfam"
                     /description="PTBA: PTS system, glucose subfamily, IIA
                     component"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_401_0002"
                     /evalue="1.10E-30"
                     /identifier="TIGR00830"
                     /label="ctg1_401"
                     /locus_tag="ctg1_401"
                     /protein_end="124"
                     /protein_start="5"
                     /score="104.1"
                     /tool="antismash"
                     /translation="TPFGGPVVALADVPDPVFAGQLVGAGVAVDPTGVEGAITAVAPVD
                     GTIVKLHPHAFALQGAAGTDVLVHVGIDTVKLSGEGFELLATEGDTVTAGDPVVRFTPS
                     VISAAGYSPICPVVV"
     CDS             complement(5177..5413)
                     /locus_tag="ctg1_402"
                     /transl_table=11
                     /translation="MADIKAADIIAALGGAENIEEVEGCITRLRVEVEDGDLVDKAALQ
                     AAGAQAVVGGGTGWQVIVGTVADNLAQDIQDEL"
     aSDomain        complement(5222..5404)
                     /aSDomain="TIGR00826"
                     /aSTool="tigrfam"
                     /description="EIIB_glc: PTS system, glucose-like IIB
                     component"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_402_0003"
                     /evalue="3.00E-14"
                     /identifier="TIGR00826"
                     /label="ctg1_402"
                     /locus_tag="ctg1_402"
                     /protein_end="64"
                     /protein_start="3"
                     /score="51.1"
                     /tool="antismash"
                     /translation="IKAADIIAALGGAENIEEVEGCITRLRVEVEDGDLVDKAALQAAG
                     AQAVVGGGTGWQVIVG"
     PFAM_domain     complement(5294..5392)
                     /aSDomain="PTS_EIIB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00367.22"
                     /description="phosphotransferase system, EIIB"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_402_0007"
                     /evalue="1.20E-14"
                     /label="ctg1_402"
                     /locus_tag="ctg1_402"
                     /protein_end="40"
                     /protein_start="7"
                     /score="53.6"
                     /tool="antismash"
                     /translation="DIIAALGGAENIEEVEGCITRLRVEVEDGDLVD"
     CDS             5592..6860
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145:Glucose-specific phosphotransferase enzyme IIA
                     (Score: 435.5; E-value: 3.8e-132)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_403"
                     /transl_table=11
                     /translation="MSATTATDVPEKKKPKKQSRLFAQAQRLGRSLLLPIAVMPAAGIL
                     LRIGQPDLLGAIPGFGQWAGVISAAGNGVFNWLPLLFAVGIAIGWAKKSDGTTALAAVV
                     GYMVMFEVWKVMSPIVLDGVKDANGDQAMINFGVLGGIVMGLVSAVMWEKFHRTKMPDF
                     LGFFSGRRLVPILTAVAGLVIAVAMSFVYRYFDIALTAAGTAVADNAVIGGGIFGFVNR
                     MLIPIGLHQLLNFFPWFQLGSFTGADGVIYHGDIARFLNGDPTAGIFQTGFFPIMMFAL
                     PAGALAIWRNAKPQNRKLVGGIMISAALTSFVTGITEPLEYSFMFVAFPLYVIHAVLTG
                     TSLALVNALGIHDGFSFSAGAIDYVLNFGKADGAIWLIPIGLGYAVVYYFLFSFVIKKW
                     NLRTPGREEDTIAENTIDAATKP"
     PFAM_domain     5679..6611
                     /aSDomain="PTS_EIIC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02378.20"
                     /description="Phosphotransferase system, EIIC"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_403_0008"
                     /evalue="1.30E-66"
                     /label="ctg1_403"
                     /locus_tag="ctg1_403"
                     /protein_end="340"
                     /protein_start="29"
                     /score="225.0"
                     /tool="antismash"
                     /translation="RSLLLPIAVMPAAGILLRIGQPDLLGAIPGFGQWAGVISAAGNGV
                     FNWLPLLFAVGIAIGWAKKSDGTTALAAVVGYMVMFEVWKVMSPIVLDGVKDANGDQAM
                     INFGVLGGIVMGLVSAVMWEKFHRTKMPDFLGFFSGRRLVPILTAVAGLVIAVAMSFVY
                     RYFDIALTAAGTAVADNAVIGGGIFGFVNRMLIPIGLHQLLNFFPWFQLGSFTGADGVI
                     YHGDIARFLNGDPTAGIFQTGFFPIMMFALPAGALAIWRNAKPQNRKLVGGIMISAALT
                     SFVTGITEPLEYSFMFVAFPLYVIHAVLTG"
     CDS             6988..7902
                     /gene_functions="transport (smcogs) SMCOG1252:cation ABC
                     transporter, periplasmic (Score: 189.8; E-value: 1e-57)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_404"
                     /transl_table=11
                     /translation="MHNRLLALPLVAGTAALALTGCATSSASGEASSSDGTINVVASTN
                     VYGSIVKTIGGDAVTVTSILSDPSQDPHSFESSARTQLSVSKADLLIENGGGYDDFMTT
                     LANASDTKADTINVVKLSGLDKGGSAEFNEHVFYSYPTMVKLVEAVTKDLSALDESGKD
                     AFEKNAATLTTKLEDLESQTDAVKKQDSGDKVAYTEPVPGYLFDAMGLENETPPEFSEA
                     IEEGDDVPPAALRDTLALFTGKRVQLLAYNNQASSPETEQVQKAAEQNDIPVVGVTETL
                     PKGQDYVSWQQANIDAVKAALQK"
     PFAM_domain     7105..7887
                     /aSDomain="ZnuA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01297.19"
                     /description="Zinc-uptake complex component A periplasmic"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_404_0009"
                     /evalue="1.50E-41"
                     /label="ctg1_404"
                     /locus_tag="ctg1_404"
                     /protein_end="300"
                     /protein_start="39"
                     /score="142.8"
                     /tool="antismash"
                     /translation="VVASTNVYGSIVKTIGGDAVTVTSILSDPSQDPHSFESSARTQLS
                     VSKADLLIENGGGYDDFMTTLANASDTKADTINVVKLSGLDKGGSAEFNEHVFYSYPTM
                     VKLVEAVTKDLSALDESGKDAFEKNAATLTTKLEDLESQTDAVKKQDSGDKVAYTEPVP
                     GYLFDAMGLENETPPEFSEAIEEGDDVPPAALRDTLALFTGKRVQLLAYNNQASSPETE
                     QVQKAAEQNDIPVVGVTETLPKGQDYVSWQQANIDAVKA"
ORIGIN
        1 atggtccacc agctcctgac cccttcgcag gagatccgaa cggatcgcct cctgctcacc
       61 ccgctgaccc cggccgacat cgacgacgtg cacgcgctct tctcggacgc ccgcacgtgg
      121 cagcacctgc ccacgggtcg gcacgtggcg cggagctcga gcgtggacat ggtgcagcgc
      181 aagatcggcg gtcgtgcacg ccacggcctc gggtcctggg cggtccgcag cgcctccgac
      241 cacgccttcg tcggggtggg cggggtcgac atgaccgccg gtggggtctg gaacctcggc
      301 taccgcctgg cgcccgcggc atgggggcag ggcttcgcgt ccgagatcgc cctcgctgcc
      361 gtccgtgccg ccgccgacac cgctccggac gtcccggtga ccggccgggt gctcacgaac
      421 aaccctgcct ctgcagccgt gctgcgtcgt gcggggctgt cgctggtgtg gcagggggcc
      481 cccgccccgc agaaccgcgc cgccgccggc gtcgaggggc aggtctggac cgatcggctg
      541 ctctccgacg agcagttcgc ctggctcgtc gccaacgcct gacccgtcag cgagcgggtc
      601 cgccgagcgt gatgctccgt gcggcgcggg cttcgaccga tgacgagtgt gtcgcgatca
      661 ggacggccgc tccgtcggcc gccagctcgc ccagcaggtc gagcaccatc gcggcgttgt
      721 cgtcgtcgag ggcactcgtc ggttcatcgg cgaggatgac cgacggacgc ttcaccagga
      781 gccgcgccat cgcgacccgt tgctgctcgc cgccgctgag ttcgtggatc cggtccgttc
      841 cgcgtccggc cagaccgaca cggtcgaggg cctcgcccgt tcggatgcct cggtgtctgc
      901 gccgtccgtc tggcaggcga accaggtcga ggttcgactg gaccgtcatg tccggcacca
      961 atccgaagtc ctggaacagg tacccgaggt ggcgccgccg gatcagtcga gcccgccgcc
     1021 cgttcgaacc tgctgactct ccgttgatcc ggatcgtgcc gtcgtcgagc gcatcgatgt
     1081 gcccgatgca gtcgagcagc gtcgacttcc cgcagccgct cggcccgacc aagccgacga
     1141 tctctccgcc cgtcacctcg aacgacaggt cgtgccacag cgcgcggccc ccgcgacgct
     1201 tcgatgcgtt ccgtacctcg atcatcgtga tccgttccct cggttgcgtg cagtgctccg
     1261 cgccgtgacg gccatgacga cgaggctcgt ggcgctcagc gccgcgagcg ccacgagcgc
     1321 gagcgccccg gcgactccgg ccgactgcgc gaccgggtcg agtgccgatc tgagcccgct
     1381 tccgtccggg cgttgcgacc accaggtgtt gacgacggcg atgacggcga tcgagaccag
     1441 accggcttcg atcgtcagca ggccagcatc ggtgcggacg ggcgagacgc cactggtgaa
     1501 cttcgcgaac agcacacggc cgtgacggcg tcggtacgcg atcgtggcga ccatcccgag
     1561 catgacgctg acagcgaggg tgctgaccag ggtgcccgtc ccgatcgcca cggtcgtcgc
     1621 tgcgcgccgt gcctgttccg ccgcagactg acccaccgcg acgaccgcgc tgaactcgtc
     1681 gcggagcccc gacgcgccga tcgaccgctc ggcggcagca cgggacgtga agacgacgtc
     1741 tccggtcgac aaccacgatc cgagttcatc ggccgagaag acgtcgaccg gtgtgggaac
     1801 gaccacgatc acggcatcgt cgagccacgc gcgcgacgat gcgtcgtccg ggtacgagta
     1861 gacctgctgg cgtgccagcg tgccaccggt gacgtgctcg aggagggcgt cgggtgcatc
     1921 ccgcaactgc cattcggtca agccctcgac gagccgctcg cgggagaggt cactgtcggc
     1981 aggcatccac acggcgatct ccgcgccgtc ggtggtgatg cgggccccgt ccgcggaacg
     2041 gacttcctgc aggtcgaggt agccctggtc gacgacgagc gcaggaaccg tggacttccc
     2101 gctgccactc gacacctcga ccgcggcggc gaggaacgca tcacgccgct cgagcgcccc
     2161 accggcgaaa tcgccgatgc ggtcccagta ggcctgctcc tcgaccgggc ggggatccgg
     2221 ggtgacccag agctggacgg tttcgccggc cgcccgaaga tcccgttctg ccgttccctg
     2281 tcgcgcggtg gtcaccgccc cggtcagttc gaagacggcc gcgacgagca acaggagcgt
     2341 gggcacccgt gcgatctgtg cgacgagcag gagcgcgccg gctggtcgag cgccccgcag
     2401 tgcgccggcc aacggctgtc gacacgcgag caccgtgccg atcgtgtgcg cgacgacgac
     2461 cggaacgagc agccccacgc agaacaccga gatcgcggcg gcgagggtcg ctgccgaagc
     2521 gagcccgttg tagaaccaga gcccggtggc cgcgacgggt accccgatga cggtgacgag
     2581 cacagcggtc cggagctcag caagctcctg gacgacgatg gcggctgtgg tgtctccgtg
     2641 cagtcggcgg actgcgctgc ggcgaggggc cccgacggtc gtcatcaggc agagcgccac
     2701 gcatcccgag acgagtgctc cgaccagggc cagggtctga tccaagccgt cggtgactcc
     2761 gatgcgttgc aggagcggca cgcgctccac gctgacctcg tacccggcgt ctgccagtgc
     2821 ggtcacgacg gctcgccgag cgtcgtcgtc cccgaagacc gagtacgagc cggtcgggtc
     2881 gaactggtcg agttccgaca tcggacggac ggtggtgacc atcgacctcg tgaagtcctc
     2941 gtacccgtcg aggagccagc cggctccgcg gctcgaggga gcgtcggtga cgagtgccac
     3001 gcggcgcgtc gtcggagctt cgcggtccgc caccacccgt gcgatcgtcg cgtgctcggc
     3061 ctcggcgacc tgctcgagtg cggtcgcgac ccgctggttc gatccggtct cagcaccggc
     3121 ggcagcggtc accacggacg aggcgcccac gatgccggct tcactgacct gcaccaggcc
     3181 gatgaaaccc aggacggaag ccaggagggg cgggacgagg taggcgagcg tcaccgatcg
     3241 gatgttcatg gtcccccttg cggcgagcgt gagctggagc ggacggtctc tcgggaccgc
     3301 ccgctcccgg tctcagcagt tgtggtagta cgccttcttg ccgctgcgcg ccttcggtgt
     3361 catcgccatc gcgtaccgtc cgcctggcac gttcgtgacg cgcttcgact tcttgccgac
     3421 cgcggtcgcg ccgtggcacc gcttctcgcg gaagtagttc gaccaggtgt cgtccttgcc
     3481 gacgccccac tgccagaagc tcccgccccc gccgtcgttg tcggtaccga tgccgctggt
     3541 ctcaccgctc gcacttgcac cggaagcagc gacggccact ccgccggctt ccgaccctga
     3601 tcccatgacc tcgaactgcg cagctgatgc cgccgtcgca gtgcccgtga tcaggccgac
     3661 ggtgagaccg aggccgacga gcatcttcgt tctggacttg tgcatgactg ttttctccca
     3721 tgtgcccccc ccgatgaggc tcgaccgacc gtggcagcgg tgcagtactg atgtcaagaa
     3781 tctgaaatgc cgtgttccac ggaggctggg gtgcccgacg ttggtcttcc cggcctgact
     3841 cgctactgtg atgggaactg gtcatgtccg cgcatgacca ccgcccagga ccagcaacgg
     3901 agcacgaggg acgcatgacg agccgcatca ccgagggtgc cgaaccgaag caccagcagc
     3961 tgcggcgcat cctgctcgac ctcgtcacca cgcgactggc tcccggtgcc gcgatcccgt
     4021 ccgaacgcca gctcatcgcc gagtacggcg tctcgcggat caccgtgcgt gaagccctcg
     4081 ggcagctggt caacgagggc tacctggagc gcgtccgcgg caagggcacc ttcgtggcgc
     4141 accggcccgt gcagtcgacg ctgcacctcg cctcgttcac cgaggagatg cgggccatgg
     4201 ggcacgagcc gaccaccgtg gtgctcgtgc gtgaagagcg ggtgccgccg gccgacaccg
     4261 ccgcggccct gcggatcgac ccggacgtgc cggccttcca cgtgaagcgc ctgcggatgg
     4321 ccgatggtgc cccggtgtcg atcgacgacg cctggctcgt ggccgacgcg ttcccgggcc
     4381 tgctcgacca cgacctgtcc gggtcggtgt actcgatcat cgccacggag tacggcaccc
     4441 cgatcgaccg cgcgcagcag accgtcgcgg cgaacccggc ggccgacgac gtcgcgacgc
     4501 tgctcgggac gaagaccgga gcgcccgtgc tcgagttcga ccgggtgtcg tacgcggggg
     4561 aacgacccgt ggagcacacc cgcagctggt accgatcgga ccgctaccgg gtgcagatgg
     4621 aggtcaccgc gacccccgcg gtcgcgtagt ccgcccgaca acacgaaagc gactgtgtgc
     4681 cgcgggtgtt ccgcagtaca cagtcgctct cgaaggggga agtggcccta gacctcgaag
     4741 agggtgtcgc cgtcgagcac cgtggtgccg accgtcccct ggtcgacact gtccggcgtc
     4801 gaaccgagca cgacgaccgg gcagatcggc gagtacccgg ctgctgagat caccgagggg
     4861 gtgaaccgga cgacggggtc accggcggtg acggtgtcgc cctcggtcgc gaggagctcg
     4921 aagccctcgc cggagagctt cacggtgtcg atgccgacgt gcaccaggac gtcggtgcca
     4981 gcggcgccct gcagggcgaa cgcgtgcggg tgcagcttga cgatggtgcc gtcgaccggg
     5041 gccaccgcgg tgatcgcacc ctcgacgccc gtcgggtcga ccgcgacgcc ggcgccgacc
     5101 agctgcccgg cgaacaccgg gtcgggcacg tcggcgaggg cgacgaccgg gccgccgaac
     5161 ggggtgcgga cgacggtcac agttcgtcct ggatgtcctg ggcgaggttg tcggcgaccg
     5221 tgccgacgat gacctgccag ccggtgccgc ctccgacgac ggcctgggct ccggctgcct
     5281 gcagggcggc cttgtcgacc aggtcgccgt cctcgacctc gacgcggagg cgcgtgatgc
     5341 agccctcgac ctcttcgatg ttctcggcac cgccgagtgc ggcgatgatg tcggctgcct
     5401 tgatgtcggc catcgtttcc tcctcgttaa gggtttgcgt cgcaggttga caccggaccg
     5461 ctctcggatc agactacgga actggtcatg accggacagg accggacctg gcgacaccgc
     5521 cgaggttacc tgcgctggct gcacgactca actcaccccg acagctccac ccaatgacga
     5581 gaggacctcc gatgagcgcc accactgcca cggatgtgcc ggagaagaag aagccgaaga
     5641 agcagtcacg gctgttcgcg caggcccagc gcctcggacg gagcctgctc ctgccgatcg
     5701 cggtcatgcc cgcggcgggc atcctgctcc gcatcggcca gcccgacctc ctcggggcga
     5761 tccccggctt cggccagtgg gccggagtca tctcggcggc cggcaacggt gtcttcaact
     5821 ggctgccgct gctcttcgcg gtgggcatcg cgatcggctg ggcgaagaag tccgacggca
     5881 ccaccgcgct cgcggcggtc gtcggctaca tggtcatgtt cgaggtctgg aaggtgatgt
     5941 cgccgatcgt cctcgacggc gtgaaggacg ccaacggcga ccaggcgatg atcaacttcg
     6001 gggtgctcgg cggcatcgtg atggggctcg tctccgcggt catgtgggag aagttccacc
     6061 gcacgaagat gcccgacttc ctcgggttct tctcgggccg tcgcctcgtc cccatcctca
     6121 ccgcggtcgc gggtctcgtc atcgccgtcg cgatgtcgtt cgtgtaccgc tacttcgaca
     6181 tcgcgctgac cgcggcgggg acggccgtgg ccgacaacgc cgtcatcggc ggcggcatct
     6241 tcggcttcgt gaaccgcatg ctcatcccga tcgggctgca ccagctgctc aacttcttcc
     6301 cgtggttcca gctcggcagc ttcacgggcg cggacggcgt gatctaccac ggtgacatcg
     6361 cgcgcttcct caacggtgac ccgaccgcgg gcatcttcca gaccggcttc ttcccgatca
     6421 tgatgttcgc gctgcccgcc ggtgccctgg cgatctggcg caacgccaag ccgcagaacc
     6481 gcaagctcgt cggcggcatc atgatctccg ccgcactgac ctcgttcgtc acgggcatca
     6541 ccgagccgct cgagtactcg ttcatgttcg tcgcgttccc gctctacgtg atccacgcgg
     6601 tgctcacggg cacctcgctg gcgctggtga acgccctcgg gatccacgac gggttctcgt
     6661 tctcggccgg tgcgatcgac tacgtgctga acttcggcaa ggcggacggg gcgatctggc
     6721 tcatcccgat cggcctcggc tacgcggtcg tgtactactt cctgttcagt ttcgtgatca
     6781 agaagtggaa cctccgcacg cccgggcgtg aagaggacac gatcgccgag aacacgatcg
     6841 acgcggccac caagccgtag acgcgcgttc cgacggacgg gaggcccggt gccagctggc
     6901 accgggcctc ccgtccgtct cccggtcgcg ctgagagccc tcatagcggt tttgacaatc
     6961 gttatcagta ggcgttagcg tcgtgccatg cacaaccgcc tcctcgccct ccctctcgtc
     7021 gccggcaccg ccgcgctcgc cctgaccggg tgcgccacct cgtccgcctc gggggaggcc
     7081 agcagcagtg acggcacgat caacgtcgtc gcctccacca acgtctacgg ctcgatcgtc
     7141 aagaccatcg gtggcgacgc cgtcaccgtg acgagcatcc tgagcgaccc gtcgcaggac
     7201 ccgcactcgt tcgagtcgag cgcccgcacg caactctccg tgtcgaaggc cgacctgctc
     7261 atcgagaacg gtggcggcta cgacgacttc atgacgacgc tcgcgaacgc ctcggacacc
     7321 aaggcggaca ccatcaacgt cgtgaagctc tccggcctcg acaagggcgg cagcgccgag
     7381 ttcaacgagc acgtcttcta cagctacccc acgatggtga agctggtcga ggcggtcacg
     7441 aaggacctca gcgcgctcga cgagagcggc aaggacgcct tcgagaagaa cgccgccacg
     7501 ctcaccacca agctcgagga cctcgagtcc cagaccgacg ccgtcaagaa gcaggactcc
     7561 ggcgacaagg tggcgtacac ggagccggtg cccgggtacc tgttcgacgc gatggggctc
     7621 gagaacgaga ccccgccgga gttctccgag gccatcgagg aaggcgacga cgtcccgccg
     7681 gcggccctcc gcgacaccct cgcgctgttc accggcaagc gcgtgcagct cctcgcctac
     7741 aacaaccagg cgtcgagccc cgagaccgag caggtccaga aggcagccga gcagaacgac
     7801 atccccgtcg tcggtgtcac ggagacgctc cccaaggggc aggattacgt ctcgtggcag
     7861 caggcgaaca tcgacgcggt gaaggcagcg ctccagaagt ga
//
