GCF_030294405.1_ASM3029440v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP125718.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	T3PKS	417,486	458,655	capsular polysaccharide	Saccharide:Exopolysaccharide	3%
Region 1.2	siderophore	802,037	817,023	staphyloferrin A	Other:Non-NRP siderophore	100%
Region 1.3	cyclic-lactone-autoinducer	948,959	969,668	kijanimicin	Polyketide	4%
Region 1.4	terpene	1,286,741	1,307,559
Region 1.5	NRPS	2,560,328	2,617,124	rhizocticin A	Other	6%

No secondary metabolite regions were found in these records:: NZ_CP125719.1; NZ_CP125720.1; NZ_CP125721.1; NZ_CP125722.1; NZ_CP125723.1; NZ_CP125724.1; NZ_CP125725.1; NZ_CP125726.1

Compact view

NZ_CP125718.1 - Region 1 - T3PKS

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Location: 417,486 - 458,655 nt. (total: 41,170 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000286.1	0.22	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000255.1	0.17	Polyketide	pederin	Uncultured bacterium
BGC0000866.1	0.17	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.1	0.17	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001104.1	0.16	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0000679.1	0.16	Terpene	diazepinomicin	Micromonospora sp. M42
BGC0001739.1	0.16	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001335.1	0.16	Alkaloid	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0000205.1	0.16	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000934.1	0.16	Other (Phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000286.1	0.55	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000255.1	0.48	Polyketide	pederin	Uncultured bacterium
BGC0000866.1	0.48	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.1	0.48	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001104.1	0.47	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0000679.1	0.47	Terpene	diazepinomicin	Micromonospora sp. M42
BGC0001739.1	0.47	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001335.1	0.46	Alkaloid	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0000205.1	0.46	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000934.1	0.46	Other (Phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NZ_CP125718.1 - Region 2 - siderophore

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Location: 802,037 - 817,023 nt. (total: 14,987 nt) Show pHMM detection rules used

siderophore: IucA_IucC

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KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	0.54	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000939.1	0.30	Other	aerobactin	Grimontia hollisae
BGC0001713.1	0.28	Other	ochrobactin	Ochrobactrum anthropi
BGC0000942.1	0.25	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001870.1	0.22	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000947.1	0.19	Other	vibrioferrin	Vibrio alginolyticus
BGC0000883.1	0.17	Other	arginomycin	Streptomyces arginensis
BGC0000943.1	0.15	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001767.1	0.09	NRP	salinichelins	Salinispora pacifica CNY331
BGC0000423.1	0.09	NRP	scabichelin	Streptomyces scabiei 87.22

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	0.81	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000939.1	0.64	Other	aerobactin	Grimontia hollisae
BGC0001713.1	0.61	Other	ochrobactin	Ochrobactrum anthropi
BGC0000942.1	0.59	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001870.1	0.55	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000947.1	0.51	Other	vibrioferrin	Vibrio alginolyticus
BGC0000883.1	0.48	Other	arginomycin	Streptomyces arginensis
BGC0000943.1	0.45	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001767.1	0.34	NRP	salinichelins	Salinispora pacifica CNY331
BGC0000423.1	0.33	NRP	scabichelin	Streptomyces scabiei 87.22

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NZ_CP125718.1 - Region 3 - cyclic-lactone-autoinducer

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Location: 948,959 - 969,668 nt. (total: 20,710 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

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KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001687.1	0.17	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000540.1	0.13	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0001484.1	0.13	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0001872.1	0.09	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0000624.1	0.09	RiPP	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000433.1	0.08	NRP	surfactin	Bacillus velezensis FZB42
BGC0001053.1	0.08	NRP, Polyketide	tubulysin A	Archangium disciforme
BGC0001056.1	0.06	NRP, Polyketide	zeamine, zeamine I, zeamine II, prezeamine, prezeamine I	Serratia plymuthica RVH1
BGC0000082.1	0.06	Polyketide	kijanimicin	Actinomadura kijaniata
BGC0001700.1	0.05	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001687.1	0.49	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000540.1	0.41	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0001484.1	0.41	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0001872.1	0.34	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0000624.1	0.33	RiPP	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000433.1	0.32	NRP	surfactin	Bacillus velezensis FZB42
BGC0001053.1	0.30	NRP, Polyketide	tubulysin A	Archangium disciforme
BGC0001056.1	0.25	NRP, Polyketide	zeamine, zeamine I, zeamine II, prezeamine, prezeamine I	Serratia plymuthica RVH1
BGC0000082.1	0.25	Polyketide	kijanimicin	Actinomadura kijaniata
BGC0001700.1	0.23	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145

Similar known gene clusters

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Detailed TIGRFAM domain annotation

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NZ_CP125718.1 - Region 4 - terpene

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Location: 1,286,741 - 1,307,559 nt. (total: 20,819 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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Analysis type:

Reference	terpene	Similarity score	Type	Compound(s)	Organism
BGC0000452.1		0.07	NRP	tyrocidine	Brevibacillus brevis NBRC 100599
BGC0001053.1		0.04	NRP, Polyketide	tubulysin A	Archangium disciforme

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000452.1		0.30	NRP	tyrocidine	Brevibacillus brevis NBRC 100599
BGC0001053.1		0.18	NRP, Polyketide	tubulysin A	Archangium disciforme

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NZ_CP125718.1 - Region 5 - NRPS

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Location: 2,560,328 - 2,617,124 nt. (total: 56,797 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

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Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000308.1	0.37	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001135.1	0.30	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001844.1	0.29	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001833.1	0.29	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001131.1	0.28	NRP	ambactin	Xenorhabdus miraniensis
BGC0001758.1	0.27	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.27	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001686.1	0.27	NRP	N-octanoyl-Met-Phe-H	Clostridium sp. CAG:567
BGC0001132.1	0.26	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.1	0.26	NRP	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000308.1	0.70	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001135.1	0.63	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001844.1	0.63	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001833.1	0.62	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001131.1	0.62	NRP	ambactin	Xenorhabdus miraniensis
BGC0001758.1	0.61	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.61	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001686.1	0.61	NRP	N-octanoyl-Met-Phe-H	Clostridium sp. CAG:567
BGC0001132.1	0.60	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.1	0.59	NRP	xenematide	Xenorhabdus nematophila AN6/1

Similar known gene clusters

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Detailed TIGRFAM domain annotation

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 5, location 2560327 - 2617124:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser - ser - ser - ser - ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2437

Search NORINE for peptide: strict or relaxed

AMP-binding (450..853): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHLSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (1488..1891): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHLSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (2526..2929): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHISLVeK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 90% (moderate)

AMP-binding (3565..3968): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHLSLIeK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 90% (moderate)

AMP-binding (4603..5006): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHpSLIEK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 90% (moderate)