LOCUS       NZ_LR963104.1          10849 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LR963104.1 Aeromonas dhakensis isolate TN14 chromosome 1.
ACCESSION   NZ_LR963104
VERSION     NZ_LR963104.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:44:14
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3395371
            Orig. end    :: 3406220
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10849
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3400371:3401220](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5849)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10849
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10849
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1025..1582)
                     /locus_tag="ctg1_3011"
                     /transl_table=11
                     /translation="MATRREGRALALLAGVVASVGLSGCMGQMGLSSMVTKGNLSVVDN
                     RYGRAGVFILLSPVYGLAATADLFVFNTIEFWSGKNPITGKSPALVDQKLDALIKVNQH
                     LDPSLNKVPLALLPQGVREVEVSYPDERTAQMEVHYLDGRSSLMRGEKRGELLDIYFDG
                     RLVSTLTPAQLEEKARTVSAEV"
     PFAM_domain     complement(1049..1555)
                     /aSDomain="DUF3332"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11810.10"
                     /description="Domain of unknown function (DUF3332)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3011_0092"
                     /evalue="3.70E-42"
                     /label="ctg1_3011"
                     /locus_tag="ctg1_3011"
                     /protein_end="178"
                     /protein_start="9"
                     /score="144.0"
                     /tool="antismash"
                     /translation="LALLAGVVASVGLSGCMGQMGLSSMVTKGNLSVVDNRYGRAGVFI
                     LLSPVYGLAATADLFVFNTIEFWSGKNPITGKSPALVDQKLDALIKVNQHLDPSLNKVP
                     LALLPQGVREVEVSYPDERTAQMEVHYLDGRSSLMRGEKRGELLDIYFDGRLVSTLTPA
                     QLEEKA"
     CDS             complement(1765..3060)
                     /locus_tag="ctg1_3012"
                     /transl_table=11
                     /translation="MFNNKLKAQLQACQAQLAESQGFVEAVKAGIATIIFTPDGEILEA
                     NQPFLSLMGYSAMELQGQHHRMFCSQELARSAEYQQFWAQLKQGRVKSGIFSRRNKRGE
                     VVWLEASYFPVKSQGRVTQVIKIASDVTAEHQQLLNQEAVSKALERSLAMIEFTPSGDI
                     LSANANFLSCVGYTLNELKGRNHRILCDDAFYEENPRFWEELAQGQFKSGLFLRRNSHG
                     EAIWLEATYNPIRDESGKVSRVIKFASDITDRVTKSHAVRDATQVAHATAQETLRCAEQ
                     GAELLRSVVETSSLISEQVDKTILLINQLNEQSRSIEAIVSTISSIADQTNLLALNAAI
                     EAARAGDQGRGFAVVADEVRQLAARTSLSTDEIAKVVQKNRELTARVTDDMARVAGSAE
                     LGKQQIDKVNEVMVEIRQEANNVSATVSSLSI"
     PFAM_domain     complement(1771..2172)
                     /aSDomain="MCPsignal"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00015.23"
                     /description="Methyl-accepting chemotaxis protein (MCP)
                     signalling domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3012_0095"
                     /evalue="1.30E-35"
                     /label="ctg1_3012"
                     /locus_tag="ctg1_3012"
                     /protein_end="430"
                     /protein_start="296"
                     /score="122.9"
                     /tool="antismash"
                     /translation="SEQVDKTILLINQLNEQSRSIEAIVSTISSIADQTNLLALNAAIE
                     AARAGDQGRGFAVVADEVRQLAARTSLSTDEIAKVVQKNRELTARVTDDMARVAGSAEL
                     GKQQIDKVNEVMVEIRQEANNVSATVSSLS"
     aSDomain        complement(2293..2625)
                     /aSDomain="TIGR00229"
                     /aSTool="tigrfam"
                     /description="sensory_box: PAS domain S-box protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3012_0024"
                     /evalue="3.10E-17"
                     /identifier="TIGR00229"
                     /label="ctg1_3012"
                     /locus_tag="ctg1_3012"
                     /protein_end="256"
                     /protein_start="145"
                     /score="60.8"
                     /tool="antismash"
                     /translation="KALERSLAMIEFTPSGDILSANANFLSCVGYTLNELKGRNHRILC
                     DDAFYEENPRFWEELAQGQFKSGLFLRRNSHGEAIWLEATYNPIRDESGKVSRVIKFAS
                     DITDRVT"
     PFAM_domain     complement(2296..2598)
                     /aSDomain="PAS_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08448.12"
                     /description="PAS fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3012_0094"
                     /evalue="4.10E-09"
                     /label="ctg1_3012"
                     /locus_tag="ctg1_3012"
                     /protein_end="255"
                     /protein_start="154"
                     /score="36.8"
                     /tool="antismash"
                     /translation="IEFTPSGDILSANANFLSCVGYTLNELKGRNHRILCDDAFYEENP
                     RFWEELAQGQFKSGLFLRRNSHGEAIWLEATYNPIRDESGKVSRVIKFASDITDRV"
     aSDomain        complement(2653..2970)
                     /aSDomain="TIGR00229"
                     /aSTool="tigrfam"
                     /description="sensory_box: PAS domain S-box protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3012_0023"
                     /evalue="1.80E-16"
                     /identifier="TIGR00229"
                     /label="ctg1_3012"
                     /locus_tag="ctg1_3012"
                     /protein_end="136"
                     /protein_start="30"
                     /score="58.4"
                     /tool="antismash"
                     /translation="IATIIFTPDGEILEANQPFLSLMGYSAMELQGQHHRMFCSQELAR
                     SAEYQQFWAQLKQGRVKSGIFSRRNKRGEVVWLEASYFPVKSQGRVTQVIKIASDVTAE
                     HQ"
     PFAM_domain     complement(2677..2934)
                     /aSDomain="PAS_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08447.14"
                     /description="PAS fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3012_0093"
                     /evalue="3.10E-13"
                     /label="ctg1_3012"
                     /locus_tag="ctg1_3012"
                     /protein_end="128"
                     /protein_start="42"
                     /score="49.9"
                     /tool="antismash"
                     /translation="LEANQPFLSLMGYSAMELQGQHHRMFCSQELARSAEYQQFWAQLK
                     QGRVKSGIFSRRNKRGEVVWLEASYFPVKSQGRVTQVIKIA"
     CDS             complement(3270..3731)
                     /locus_tag="ctg1_3013"
                     /transl_table=11
                     /translation="MIIRQATQADIPALVTLRMALFCEVGELSEPLADLPLWQATTTYF
                     STAQAEESARSWVAEVDGEVVASATLALFVRPPYPGNLTGREGYLLNMYTLPAHRRQGL
                     AGALLDQMADYARGQQLGRVWLHASEEGRPLYERMGFVSNPAYLEWQPG"
     PFAM_domain     complement(3309..3590)
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3013_0096"
                     /evalue="1.70E-14"
                     /label="ctg1_3013"
                     /locus_tag="ctg1_3013"
                     /protein_end="141"
                     /protein_start="47"
                     /score="54.2"
                     /tool="antismash"
                     /translation="AQAEESARSWVAEVDGEVVASATLALFVRPPYPGNLTGREGYLLN
                     MYTLPAHRRQGLAGALLDQMADYARGQQLGRVWLHASEEGRPLYERMGF"
     CDS             complement(3804..4247)
                     /locus_tag="ctg1_3014"
                     /transl_table=11
                     /translation="MTNHKFPLMQQRGPAAPWWLSGALLLLARCWVAAVFLRSGWLKLS
                     AWDSTLYLFEFEYRVPLLPWQWAAWLGTATELLLPVLLLLGLFTRPVAALLFAFNIMAV
                     LSYPALWAGGFYDHQLWGWMLLTLAVWGAGPLALDQWRLVRRA"
     PFAM_domain     complement(3930..4178)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3014_0097"
                     /evalue="5.80E-16"
                     /label="ctg1_3014"
                     /locus_tag="ctg1_3014"
                     /protein_end="106"
                     /protein_start="23"
                     /score="59.0"
                     /tool="antismash"
                     /translation="LLLLARCWVAAVFLRSGWLKLSAWDSTLYLFEFEYRVPLLPWQWA
                     AWLGTATELLLPVLLLLGLFTRPVAALLFAFNIMAVLS"
     CDS             complement(4253..5008)
                     /locus_tag="ctg1_3015"
                     /transl_table=11
                     /translation="MSELAQRQQQFAEGLLGQSEAILPHVHSRLFPADAVLQVYRNHFI
                     LSLGEVLAGSYPAVKAMVGEAFFDAAARGFVLAEPLCEGSVMHYGAGFGDWLAGLPTTA
                     ELPWLGELARFEWALERTSLLAPEVRHWPAERVAALPPAAWQTLVLIPACDLLLFDSLR
                     PVEALWQMALHQGEAVHDLAAPAWLALKKQPDCRVLPLRLSEGEWRLLDGCRQGIALST
                     LLAQDAQAAESLTRLVTLGLLVDVTSTLE"
     PFAM_domain     complement(4718..4990)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3015_0098"
                     /evalue="5.50E-18"
                     /label="ctg1_3015"
                     /locus_tag="ctg1_3015"
                     /protein_end="97"
                     /protein_start="6"
                     /score="65.1"
                     /tool="antismash"
                     /translation="RQQQFAEGLLGQSEAILPHVHSRLFPADAVLQVYRNHFILSLGEV
                     LAGSYPAVKAMVGEAFFDAAARGFVLAEPLCEGSVMHYGAGFGDWL"
     CDS             complement(5001..5849)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3016"
                     /sec_met_domain="DUF692 (E-value: 4.5e-80, bitscore: 266.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPLIGIGLRTPHYDEMLRTLPAVGWLEVHSENYFERHSRGFQVL
                     SELARHYPVSLHGVGMSLGSADGLDLAHLASLSALAGAIKPVRISEHLSWGSIGGRHFN
                     DLLPVPYTREALLTMSDKIMQVQDALGCRLLIENPSSYLQLAGEMPEWEFLAELQRRSE
                     CGILLDLNNLYVSAFNHGFVYRDYLAAIDIATVGEIHLAGFTDKSLPQGHLYIDTHSAP
                     VSEPVWALYAEICRQRAIPTLIEWDLEIPPLPVLLAEAERASTLLDAAMAAHPASEAAH
                     V"
     PFAM_domain     complement(5049..5837)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3016_0099"
                     /evalue="1.10E-96"
                     /label="ctg1_3016"
                     /locus_tag="ctg1_3016"
                     /protein_end="267"
                     /protein_start="4"
                     /score="323.2"
                     /tool="antismash"
                     /translation="IGIGLRTPHYDEMLRTLPAVGWLEVHSENYFERHSRGFQVLSELA
                     RHYPVSLHGVGMSLGSADGLDLAHLASLSALAGAIKPVRISEHLSWGSIGGRHFNDLLP
                     VPYTREALLTMSDKIMQVQDALGCRLLIENPSSYLQLAGEMPEWEFLAELQRRSECGIL
                     LDLNNLYVSAFNHGFVYRDYLAAIDIATVGEIHLAGFTDKSLPQGHLYIDTHSAPVSEP
                     VWALYAEICRQRAIPTLIEWDLEIPPLPVLLAEAERASTLL"
     CDS             complement(5913..6176)
                     /locus_tag="ctg1_3017"
                     /transl_table=11
                     /translation="MNVKKSTAIASAMTGLLALGAQFIAAPAMAADEKEKCYGVVKASK
                     NDCATKTNSCAGTAKMDAQGDAFVVVPKGLCEKLAGGSLQPK"
     PFAM_domain     complement(5925..6077)
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3017_0100"
                     /evalue="1.40E-22"
                     /label="ctg1_3017"
                     /locus_tag="ctg1_3017"
                     /protein_end="84"
                     /protein_start="33"
                     /score="79.6"
                     /tool="antismash"
                     /translation="KEKCYGVVKASKNDCATKTNSCAGTAKMDAQGDAFVVVPKGLCEK
                     LAGGSL"
     CDS             complement(6530..7345)
                     /locus_tag="ctg1_3018"
                     /transl_table=11
                     /translation="MMQCRKFQPAPDLAPWLAQGWEWRLGQPQPMPEIFPGTGAEILFN
                     LGASLTITILSSADAPRSVTVATGAAVLLCPRHARLRFAAHGQTHLLGLRLRSSACFDL
                     FGVPLEQLSDRVLSLDELGIVCPDPQWLMQEGAGALGAWLRRQVGSRPPRDLALVRAIE
                     RLYYGTPAIELQQQLGMSARTFQRRLRCHLGVDARYYLRTARFQRALRQLLSGAPSLDA
                     LLEQGYCDQPHFIKSCHFFTGRSPGQLLTPEHQRLNHYSPQINRLAGSL"
     PFAM_domain     complement(6596..6820)
                     /aSDomain="HTH_18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12833.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3018_0101"
                     /evalue="1.50E-14"
                     /label="ctg1_3018"
                     /locus_tag="ctg1_3018"
                     /protein_end="250"
                     /protein_start="175"
                     /score="54.1"
                     /tool="antismash"
                     /translation="QQLGMSARTFQRRLRCHLGVDARYYLRTARFQRALRQLLSGAPSL
                     DALLEQGYCDQPHFIKSCHFFTGRSPGQLL"
     CDS             complement(7364..7696)
                     /locus_tag="ctg1_3019"
                     /transl_table=11
                     /translation="MSDIFKAAFIFVAPGADPACHASWVKTEKVHVKMIAVPDYQGGRE
                     LLDELYREGIRAVELCAGFGHLGVAAMVEAAAGRMEIGVVRFDRHPCLDHVSGDTLFLS
                     TSEPSQ"
     PFAM_domain     complement(7400..7681)
                     /aSDomain="DUF6506"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF20116.1"
                     /description="Family of unknown function (DUF6506)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3019_0102"
                     /evalue="3.00E-27"
                     /label="ctg1_3019"
                     /locus_tag="ctg1_3019"
                     /protein_end="99"
                     /protein_start="5"
                     /score="95.0"
                     /tool="antismash"
                     /translation="KAAFIFVAPGADPACHASWVKTEKVHVKMIAVPDYQGGRELLDEL
                     YREGIRAVELCAGFGHLGVAAMVEAAAGRMEIGVVRFDRHPCLDHVSGD"
     CDS             complement(7916..8116)
                     /locus_tag="ctg1_3020"
                     /transl_table=11
                     /translation="MFHPYSLTQIILRRLYVLLVGMLAFPVMLFRSDRARFYSYLHRIW
                     SKTSTKPVWLKMSERGERIFY"
     PFAM_domain     complement(7934..8113)
                     /aSDomain="DUF2517"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10725.11"
                     /description="Protein of unknown function (DUF2517)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3020_0103"
                     /evalue="1.00E-35"
                     /label="ctg1_3020"
                     /locus_tag="ctg1_3020"
                     /protein_end="61"
                     /protein_start="1"
                     /score="121.4"
                     /tool="antismash"
                     /translation="FHPYSLTQIILRRLYVLLVGMLAFPVMLFRSDRARFYSYLHRIWS
                     KTSTKPVWLKMSERG"
     CDS             8331..8624
                     /locus_tag="ctg1_3021"
                     /transl_table=11
                     /translation="MKPAEMAIIGILGLLIWSEWQDWQLNRDDSITLAYKGAPTVSLWQ
                     CGQLKQKMMDVTEHSAEVQFQYRGQDLTQVNRYLEREWQQQGCEQLLLQQGY"
ORIGIN
        1 gcagagcacc gcgcttgagc cagcgtcgtc tctgttcgga caaccccatc tgagtggcaa
       61 gaatgtcggt atagagtgcc actcggccgc tatgaccggc ggtgtaggga cttttggagt
      121 ccaccacctg accgaatgcc gcggcgatct cgtccagata atcttcatca agagcgacct
      181 caccctgccc ggccgggtgg acgaacaccc actcagccag cttgggatcc gccagtcctt
      241 gccaaaaatc accatccgcc aaggcttcaa actcgctaac caattgaggg tcaaaccagc
      301 tgccgctgcg ctcgcgcagc tcttttagca ccgcatcagg gcctgcggcg gcgtgaaaca
      361 catccaccac ctggcagagc agcgctatgc gagagaagag cgggatcgcg tcaccgacca
      421 gttgcaacgg ccgaccttta ccgttccagt gttcgtccag agagaggata ccggtagcga
      481 cctcttcact gaaacgcagt tgacgagcga tgtccgcccc ccgatggcaa cgggtctgga
      541 tcagttcgtt ggctatctga tcgccgttgc gaaagatgtg aaacaggctg cgaaaacgcc
      601 caagcagatc cgcctgcagg ccggtgtggc ccagcacgaa gttgaccacc tcggagagag
      661 agccatccac cagcttgaag tcgcgtttga agtgaagatc gtcggtgaga tagagttcgc
      721 agatacgggc cgcattgctg ctgcacccca gatccttgag cagcagcatg taatagaggt
      781 catgacgctg tcgagcatcc agcgccaacc gttcggccag acgggaacct atccagcaac
      841 agcgaataca gtgccctctt ggttgaccct cggtcatgtc gagcgcatga ctgagggaac
      901 caatcaactc tgccaaccgc aatccattca ccgtcatagc ctgtatccct ggtcatcttg
      961 gcgatcttgc ctgctgacta ggtatacctt atccagagag gaatagatct ggattcagat
     1021 gaatttatac ctcggcgcta acggtccgtg ctttttcctc cagctgggcc ggcgtcaggg
     1081 tcgacaccag ccggccgtcg aagtagatat ccaacagctc gccgcgcttc tcgccgcgca
     1141 tcaggctgct gcgcccgtcc agatagtgca cctccatctg ggcggtgcgc tcgtccgggt
     1201 agctcacctc cacctcgcgt accccttgtg gcagcagggc cagcggcacc ttgttgaggg
     1261 agggatccag gtgctggttg accttgatca gggcgtcgag cttctgatcc accagcgccg
     1321 gcgacttgcc ggtgatgggg ttcttgcccg accagaattc gatggtgttg aacacgaaga
     1381 gatccgcggt ggccgccaga ccgtagaccg gcgagagcag gatgaagacc ccggcccggc
     1441 cgtaacggtt gtccaccacg ctgaggttgc ccttggtcac catggaggag agccccatct
     1501 gccccatgca gccgctcagt cccacgcttg ctaccacacc tgccagcagc gccagcgccc
     1561 tgccctctct tctcgttgcc atcgtcttta tctgctccaa aaataatgag gcggcaagcc
     1621 taaacaggct gccgccgacg ggcaattcac aagcagggag cgatacagca ggggttcaga
     1681 ttgggatttc gactgctcat attgcgtgca ggtcgttgaa atagtggtca aggcggcccg
     1741 catgaagaga aggccgccag ctgactagat ggagaggctg gagacggttg ccgagacgtt
     1801 gttggcctcc tgccggatct ccaccatcac ctcgttgacc ttgtcgatct gctgcttgcc
     1861 gagctcggcg ctgccggcca ccctggccat gtcgtcggtc actctggcag tcagctcgcg
     1921 gttcttctgc accaccttgg ctatctcgtc ggtggagagc gacgtgcgag ccgccagctg
     1981 gcgcacctcg tcggccacca ccgcgaaacc acgcccctga tccccggcgc gggccgcctc
     2041 gatggccgca ttgagggcca gcagattggt ctgatcggcg atgctgctga tggtggagac
     2101 gatggcctct atgcttctgg actgctcgtt gagctggttg atgagcagga tggtcttgtc
     2161 cacctgctcg ctgatgagcg acgaggtctc caccacggag cgcagcaact cagccccctg
     2221 ttcggcacag cgcagggtct cctgcgccgt ggcgtgagcc acctgggtgg catcgcgcac
     2281 cgcatggctc ttggtgacac gatcagtaat gtcgctggca aacttgatga cccggctcac
     2341 cttgccgctc tcgtcgcgaa tggggttgta ggtggcctcc agccagatcg cctcgccatg
     2401 gctgttgcgc cgcaggaaga gcccggactt gaattgcccc tgagccagct cttcccagaa
     2461 gcgggggttc tcctcataga aggcgtcatc gcacaggatg cggtgattgc gccccttgag
     2521 ctcgttcagg gtgtagccga cgcaactcag gaagttggcg ttggccgaga ggatgtcgcc
     2581 gctcggggtg aactcgatca tcgccagcga gcgttcgagc gccttggaga ccgcctcctg
     2641 gttaagcagc tgctgatgct cggcggtaac gtcgctggcg atcttgatca cctgggtcac
     2701 cctgccctgc gactttaccg ggaagtagct ggcctccagc cagaccacct cgccccgctt
     2761 gttgcggcgc gagaagatgc cggacttgac cctgccctgc ttgagctggg cccagaactg
     2821 ctggtactcg gcggagcggg ccagctcctg gctgcaaaac atccggtggt gctgaccctg
     2881 cagctccatg gcgctgtaac ccatcaggct cagaaatggc tgattggcct ccaggatctc
     2941 gccatccggg gtgaagatga tggtcgcgat cccggccttg accgcctcca cgaagccctg
     3001 tgactcggcg agctgtgcct ggcaggcctg cagttgcgcc ttcagcttgt tgttgaacat
     3061 gggtgtcata cctctgtaat gacctgacaa ggtgggaacg ggcacaagac tcggcgtcaa
     3121 ggtgaaccgg cacgagcctg ttgaggctga tcatagttga gcatggtgac tcgatcagaa
     3181 tttggccgag attttgccac agccagggag aggttcgcag cgcccgtatc ccgttggcag
     3241 gcgtgatacg ggcagggcgg caagcgggat cacccgggtt gccactccag ataggcgggg
     3301 ttgctcacaa accccatccg ctcgtagagg ggccgcccct cttcgctggc atggagccag
     3361 acccggccca gctgctgccc cctcgcatag tccgccatct ggtccagcag ggcaccggcc
     3421 agtccctgcc ggcgatgggc aggcagggta tacatgttga gcagatagcc ctccctcccc
     3481 gtcagattgc cgggataggg cgggcgcacg aagagcgcca gggttgcgct cgccaccacc
     3541 tcgccatcca cctccgccac ccaggagcgg gcactctcct cggcctgcgc cgtgctgaaa
     3601 taggtggtgg tggcctgcca cagcggcaga tcggccaacg gctcgctcag ctcccccacc
     3661 tcgcaaaaca gcgccatgcg cagggtcacc agcgcgggaa tgtctgcctg cgttgcctgc
     3721 cggatgatca tcgcctctcc tccttgtgat gaaatgaaca ggcaccccgc agggtgcctg
     3781 atgagagtgc cagtgtggcg gcttcatgcc cgcctgacaa ggcgccactg atccagggcc
     3841 agcggccccg ccccccacac cgccagggtc agcagcatcc agccccacaa ctggtgatcg
     3901 taaaagccgc cggcccagag ggcgggatag gagagcaccg ccatgatgtt gaaggcaaac
     3961 agcagggcgg cgaccggtcg ggtgaagagc ccaagcagca gcagcaccgg cagcagcaac
     4021 tcggtggccg tccccagcca ggctgcccac tgccagggca gcaggggcac ccgatactcg
     4081 aactcgaaca ggtaaagggt gctgtcccag gcgctcagct tgagccagcc ggagcgcaag
     4141 aagaccgccg ccacccagca tctggccagc agcaacaggg caccgctcag ccaccagggg
     4201 gcggccggcc cccgttgctg catcaggggg aacttgtggt ttgtcatcga atttactcca
     4261 gcgttgaggt cacatcgacc agcaggccca gggtgacgag gcgggtcaga gactctgcag
     4321 cctgcgcatc ttgcgccagc agggtcgaca gggcgatgcc ctggcggcag ccatccagca
     4381 ggcgccactc cccctcgctc aggcgcagcg gcaatacccg acaatcgggc tgtttcttga
     4441 gggcgagcca ggcgggggcc gccagatcgt gcaccgcctc accctggtgc agagccatct
     4501 gccagagggc ctccaccggg cgaaggctgt cgaacagaag cagatcacag gccgggatca
     4561 gcaccagcgt ctgccaggcc gctggcggca gggccgccac ccgctcggcc ggccagtggc
     4621 gcacctcggg ggcaagcagg ctggtgcgct ccagtgccca ctcgaaacgg gcaagctccc
     4681 ccagccaggg cagttcggcg gtggtgggca gcccggcgag ccagtcgcca aagcctgcgc
     4741 cgtagtgcat cacgctccct tcgcagaggg gctccgccag cacgaagccg cgcgccgcgg
     4801 cgtcgaaaaa cgcctccccc accatggcct tgaccgccgg gtagctgccc gccagcacct
     4861 cgccaaggct caggatgaag tggttgcgat agacctgcag cacggcatcg gccgggaaga
     4921 ggcgggagtg gacgtggggc agaatggcct cgctctggcc aagcagcccc tcggcaaact
     4981 gctgctgccg ttgggccagc tcagacatgg gcggcctccg acgcaggatg ggcagccatg
     5041 gcggcatcca gcagggtgct cgcacgctcg gcctccgcca acagcacggg gagcggcggt
     5101 atctcgagat cccactcgat cagggtgggg atggcgcgct ggcggcagat ctcggcatag
     5161 agggcccaga ccggctcgct caccggcgcg ctgtgggtat cgatatagag gtgcccctgc
     5221 ggcagggact tgtcagtaaa accggccagg tggatttcac ccacggtggc gatgtcgatg
     5281 gcagccagat agtcacggta cacaaagccg tggttgaagg cactgacgta gaggttgttg
     5341 agatcgagca ggatgccgca ctcgctgcgc cgttgcagct cggccagaaa ctcccactcc
     5401 ggcatctctc ccgccagttg caggtaagaa gaggggttct cgatcagcag ccggcaaccg
     5461 agtgcatcct gcacctgcat gatcttgtcg ctcatggtga gcagggcctc ccgggtatag
     5521 ggcaccggca gcagatcgtt gaagtggcgc cccccgatgc tgccccagct gaggtgttcc
     5581 gagatgcgca ccggcttgat ggcgccagcc agggccgaga ggctggcaag gtgagcaagg
     5641 tcgagcccat cggccgaccc cagggacatg ccgaccccgt gcaggctgac cggatagtgc
     5701 cgggccagct cgctcaatac ctgaaaaccc cggctgtgcc gttcgaagta attctcgctg
     5761 tgcacctcca gccagccgac ggccggcagg gtacgcagca tctcgtcgta atggggggtt
     5821 cgcaatccaa taccaatcaa ggggttcatc gcaaagactc gcggttggcc atcaaaagag
     5881 agccacggtg cacaacaccg tggcacccag ccttacttgg gttgcagcga accgccagcc
     5941 agcttctcgc acagcccctt gggcaccacc acgaaggcgt cgccctgggc atccatcttg
     6001 gcggtgccgg cgcaggagtt ggtcttggtc gcacagtcgt tcttgctcgc cttcaccacg
     6061 ccgtagcact tctccttctc gtcggcagcc atggccgggg cggcaatgaa ctgggcgccg
     6121 agggccagca gaccggtcat ggcggaggcg atggcagtgc tctttttaac gttcattctc
     6181 tgttccttct gattgtgtgt ggtgtgcccg atcattcgcg accggatgcc ttccatagaa
     6241 ccggcgctgc gacgaaatga tttcaaaaaa aatgcaaaat cggcacatct ataaaaaaca
     6301 caattagtat catgctgttt taaaaagagt tttaagaatg ctctcggcca cttgccattg
     6361 acatcaagac ggcgacagag acgatggcat gacgatgaag aggagcacag gttcgcctcc
     6421 ccgaccatcc cgacgcgggt ttgcctgcat attttcacca gcgcgcggcg gcgagaggcg
     6481 agctggtcgc aagacaagat gaatggaaag cgccgagcgg gctgggtcgt caaagcgatc
     6541 cggccagccg gtttatctgc gggctgtagt ggttgaggcg ctggtgctca ggggtaagca
     6601 gttgcccggg cgagcgcccg gtaaagaagt ggcagctctt gatgaaatgg ggctgatcgc
     6661 aatagccctg ttccagcagg gcatcgagcg acggggcgcc cgacagcagc tggcgcagcg
     6721 ccctttgaaa gcgggcggta cgcagataat agcgggcatc taccccgaga tggcagcgca
     6781 atcgccgctg aaaggtacgt gcgctcatcc ccagttgctg ctgcaactcg atcgccggcg
     6841 tgccgtaata gagccgctct atcgcccgta ccagcgcaag atcccgcggc ggacgactcc
     6901 ctacctgccg gcgcaaccag gcccccagcg cccctgcccc ctcctgcatc aaccactgcg
     6961 ggtcggggca gacaatcccc agctcatcga gggacagcac ccgatcgctc aactgctcga
     7021 gcggcacgcc aaacagatcg aaacaggccg aagagcgcag ccgcagcccc agcagatgag
     7081 tctggccatg ggcggcaaag cgcaggcggg catggcgcgg gcagagcaac acggccgccc
     7141 ccgtggccac ggtgacgctg cggggcgcgt ctgctgacga gaggatcgtg atggtgaggg
     7201 aagcccccag attgaacagg atctcggccc cggtgccggg gaagatctca ggcatcggct
     7261 ggggctggcc aaggcgccac tcccaacctt gcgccagcca gggcgccaga tcgggagcgg
     7321 gctgaaattt acggcactgc atcatgatgg gaggcgatgt tgctcactgg ctcggttcgg
     7381 aggtggacag gaagagggta tcaccgctga catggtcgag acagggatgg cgatcgaagc
     7441 gcaccacgcc tatctccatg cgccccgcgg ccgcctccac catggcggcg acccccaggt
     7501 gaccgaaccc ggcacagagc tccaccgccc ggatcccctc ccgatatagc tcgtcgagca
     7561 gttcacggcc tccctggtag tcgggcacgg cgatcatctt cacatggact ttctccgtct
     7621 tgacccagct ggcgtggcag gcgggatccg cccccggtgc aacgaagatg aaggcggcct
     7681 tgaaaatatc ggacatataa aaagctcctc ggatcaatga gtcgccactc tacccgggat
     7741 cccgcgggcc ggattgtacc gcggcgccac ccgctctcat caggcaggac aaaacctggc
     7801 gcaaggggcg ccatacagac ctcatttctc cctgttgaat gcaatttgcg cggccagggg
     7861 ccataaatgc aaaagagaca gccgaagctg tctcttttgt catcaagccg ggacctcagt
     7921 agaagatccg ctcgccgcgc tcgctcatct tgagccatac cggtttggtg ctggttttgc
     7981 tccagatccg gtgcagatag ctgtagaaac gggcccggtc gctgcgaaac agcatcacgg
     8041 ggaaggccag catacccacc agcagcacat agaggcgacg aagaattatc tgagtaaggg
     8101 aatagggatg aaacatgata gcactcctca ctggtaagac cactgagcaa agattactcc
     8161 acaatttgta ggattactac accaggaatc ccattttttc gcaaaaaacg ccctggaaag
     8221 ccacaaagtg aaattgggtt acatccatta acttacaggc aacaaaagct ggcaaagcgg
     8281 ccgcgtttga ccagatttaa tgagttggta gtcaacatgg agtcaaggcg atgaaacccg
     8341 cagaaatggc gatcataggg atcctgggcc tgctgatctg gtcagaatgg caggactggc
     8401 agctcaaccg ggacgacagc atcaccctgg cctacaaggg ggcccccacc gtcagcctgt
     8461 ggcagtgcgg tcagttgaaa cagaagatga tggatgtgac cgaacactcg gccgaagtgc
     8521 agtttcagta ccggggacag gacctgacac aggtaaaccg ctatctggag cgggagtggc
     8581 agcagcaggg ttgcgaacag ttgttgctgc agcagggata ctgatacgac aaaacgccgc
     8641 acgaaacggt cgatatggga aaattcagac agggagaaga tggaggcacg ttccggagtc
     8701 gaaccggact aaacggattt gcaatccgct gcataaccgc tttgctaacg cgccatgctg
     8761 acaaggcatt gccttgaaag tgatatccat gattggtgcc atggaaaatt ggagcgggaa
     8821 acgagactct aactcgcgac cccgaccttg gcaaggtcgt gctctaccaa ctgagctatt
     8881 cccgcattac tgcttgtgtg ccagttgcct gacaacgagg cgcattatac gtaccccgag
     8941 cagaggcaca accctttttt ctcactttca gccctttctc gtgctgtttg ctcagggttt
     9001 agacggcttg cccaaaaaaa acgcgccagg ctgtgaccca gcaggcgaat tcaagataaa
     9061 gtcattgaaa tgattagcct ttaatcagag acttgcggcg gttagtaacc ggattctcaa
     9121 ttgaaaatct cccgatgaaa tggatcttca agcctcgtgg actcaggccg cagctgatgc
     9181 tggcattttt tatgctggcc atggtgccct tcctggttgt caccctgttt ttcctctata
     9241 gccacggcaa ggatctcacc acccagacct ccaaccatct ggtttccgtt cgcaacatca
     9301 agaaaagcca gctggaagat tacttcggca acctaaaaca gcagatcatc aacttttccc
     9361 agcaggattt tgccggcaac agtatcggtc gcttctacgg cttcaccggc gccttcgaga
     9421 aactcggcac cacgccgcaa gaagcccgcg cccgcgccca ggcccgctat gtgccgggct
     9481 cctgggatca gctgcaaaag cccgacaaca cccccgacat agaaccctcc atcagtgccc
     9541 tgatcctggc ggacgagatg tatggccggg tgcatcagcg ctttcaccgc ggctacgccg
     9601 acatggtgcg caagtccaac tacagcgaca tcttcctgat cgatctcaac ggcgacgtgg
     9661 tctattcggt caccaagcgc gccaacttcg ccaccaacct gctctccggc ccctaccaat
     9721 cgagtggtct gggccagacc ttcgccaaga tcaagcggcg cctcgacgga ggccagaagc
     9781 cgcaacagat cttcgagttc accgattttg gccgcaacga gctgaccggc caggtggtcg
     9841 cctacatggc cgcccccgtg atgcagtacg actatgtgcg cggcgtggtg atcttcgagc
     9901 tgctgccgga caagctcaac cagatcatgg cggagcggga ggggctcggt gcaaccggtg
     9961 agaccattct catcggcccg gacaagcgga tgcgcgccaa cgcctggctg gctcccgaat
    10021 tcagcgtgga gaacagcttc agccccaact tccggccact gcagacgccg ctggtggtca
    10081 aggcgctctc cggcgagcag ggggtcgggc tgtttcgctc ctaccacgag gacgaggtgc
    10141 tggcggccta cacccaggtg aaagtgttcg acaccgagtg ggccttcatc gccgagatct
    10201 ccaccagcga ggcctatcgc cccatccgcc agctggagac cctggtgatc ctgttggggg
    10261 ccggctcatt gttgctgctg atcctcttct cccgctggct ctcccactcc atcacggcgc
    10321 cgctgcgctc cctcaccgcc gccgccgaac aagtggccga tggcgccctg gatcacccca
    10381 tcgccatcgc ccgcaccgat gacgacatcg accggctcgc ccaggcgttt cgccacatgc
    10441 agcgctcggt gaaggacaag atcgagctca tcgagcgcca gacccaggag ctgcagcagc
    10501 aggtcaagct gacccacaag cagaacctca gcctgcagca ggcggacaag ctcaaggatg
    10561 agctgctggc caacacctcc cacgagctgc gcacccccat ccacggcatc aaggggatgg
    10621 ccgagtccat gctcgccagc cagcaggact tgaccgaagg gcagcagaaa cagctggggc
    10681 tcatcatcaa gagtgccgac ggcctggcgc ggctggtgga cgatctcctc gactaccacc
    10741 agatgcgcta cggccagctg gagatccacc cccagcctgt ctcctccaag ggggtcatcc
    10801 ggctggtgct ggatctctgc cagcacctgg tgcaggccaa acccctcac
//
