LOCUS       NZ_CP018312.1          10873 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP018312.1 Vibrio rotiferianus strain B64D1 chromosome 2,
            complete sequence.
ACCESSION   NZ_CP018312
VERSION     NZ_CP018312.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:13:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3180471
            Orig. end    :: 3191344
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10873
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3185471:3186344](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5873)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10873
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10873
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1133..2104)
                     /gene_functions="regulatory (smcogs) SMCOG1125:LysR family
                     transcriptional regulator (Score: 256.4; E-value: 6.3e-78)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_2795"
                     /transl_table=11
                     /translation="MTIIPMGKITVNVEKLARIDLNLLVCFKVLIEELNVTRAAHRLCL
                     SQSAVSKSLAKLRTQFDDPLFTRNSHGLTPTPRALFLKPKLDLLINQLEVLTQPEEFSP
                     QSSEYRFQIAAVESVYPLILPHFLPAIFQQAPGVTISTHSWSEQTFKMIQRGEIDLGMT
                     GRDIDINDAKLTMLPPDDICEQEIYRDHQMCIVRKDHPALSGNWNLEAYLALRHVQVRC
                     DGNDRWLLDYRLADIGRERDIAVTVPDFNSAASLCSYTDFVFTAPSHFVKLAAKQHDMA
                     LLPLPLEFPPMAYTLFWHRDRENDPALTWLRTMITKKTNHLR"
     PFAM_domain     complement(1154..1789)
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2795_0045"
                     /evalue="9.20E-30"
                     /label="ctg2_2795"
                     /locus_tag="ctg2_2795"
                     /protein_end="317"
                     /protein_start="105"
                     /score="103.7"
                     /tool="antismash"
                     /translation="SSEYRFQIAAVESVYPLILPHFLPAIFQQAPGVTISTHSWSEQTF
                     KMIQRGEIDLGMTGRDIDINDAKLTMLPPDDICEQEIYRDHQMCIVRKDHPALSGNWNL
                     EAYLALRHVQVRCDGNDRWLLDYRLADIGRERDIAVTVPDFNSAASLCSYTDFVFTAPS
                     HFVKLAAKQHDMALLPLPLEFPPMAYTLFWHRDRENDPALTWLRTMITK"
     PFAM_domain     complement(1868..2044)
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2795_0044"
                     /evalue="3.10E-16"
                     /label="ctg2_2795"
                     /locus_tag="ctg2_2795"
                     /protein_end="79"
                     /protein_start="20"
                     /score="59.2"
                     /tool="antismash"
                     /translation="LNLLVCFKVLIEELNVTRAAHRLCLSQSAVSKSLAKLRTQFDDPL
                     FTRNSHGLTPTPRA"
     CDS             2182..3375
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 91; E-value:
                     9.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg2_2796"
                     /transl_table=11
                     /translation="VSSHITNSKKQMALLTMLVLFSPLAIDIYLPALPLIASTFQVENA
                     LAQDTITWFLFAMGVGQLFAGPLADKLGRRTVALGGITIYALSALLAWSAQNIEWMLMA
                     RLLQGLGACATSVAAFATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDW
                     RANFSFMAGFAVIAGAMMFLGMKETNPATEKQAVFKLSRYWAVLSTPSFIFHASLCLMA
                     MAVILAYVTSAPVVLMTGMGLSMNEFTFWFGLNAAFNIAACMLAPKFMDRWGTHNSLVV
                     GISLLAIAGVIMMVMKEHYTALSFMLPIFISSVGFAWILGAAAGKALEPFGDKAGTAAA
                     LLGLFQMSGAGLLVGTLQRLSLDPQTLIAIHMWVLLPALLILFSKAGKKWHAKLANA"
     aSDomain        2206..3309
                     /aSDomain="TIGR00710"
                     /aSTool="tigrfam"
                     /description="efflux_Bcr_CflA: drug resistance transporter,
                     Bcr/CflA subfamily"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_2796_0015"
                     /evalue="6.50E-73"
                     /identifier="TIGR00710"
                     /label="ctg2_2796"
                     /locus_tag="ctg2_2796"
                     /protein_end="376"
                     /protein_start="8"
                     /score="244.3"
                     /tool="antismash"
                     /translation="KKQMALLTMLVLFSPLAIDIYLPALPLIASTFQVENALAQDTITW
                     FLFAMGVGQLFAGPLADKLGRRTVALGGITIYALSALLAWSAQNIEWMLMARLLQGLGA
                     CATSVAAFATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMA
                     GFAVIAGAMMFLGMKETNPATEKQAVFKLSRYWAVLSTPSFIFHASLCLMAMAVILAYV
                     TSAPVVLMTGMGLSMNEFTFWFGLNAAFNIAACMLAPKFMDRWGTHNSLVVGISLLAIA
                     GVIMMVMKEHYTALSFMLPIFISSVGFAWILGAAAGKALEPFGDKAGTAAALLGLFQMS
                     GAGLLVGTLQRLSLDPQTLIAIHMWVLL"
     PFAM_domain     2230..3237
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2796_0046"
                     /evalue="2.40E-45"
                     /label="ctg2_2796"
                     /locus_tag="ctg2_2796"
                     /protein_end="352"
                     /protein_start="16"
                     /score="155.1"
                     /tool="antismash"
                     /translation="MLVLFSPLAIDIYLPALPLIASTFQVENALAQDTITWFLFAMGVG
                     QLFAGPLADKLGRRTVALGGITIYALSALLAWSAQNIEWMLMARLLQGLGACATSVAAF
                     ATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMAGFAVIAGA
                     MMFLGMKETNPATEKQAVFKLSRYWAVLSTPSFIFHASLCLMAMAVILAYVTSAPVVLM
                     TGMGLSMNEFTFWFGLNAAFNIAACMLAPKFMDRWGTHNSLVVGISLLAIAGVIMMVMK
                     EHYTALSFMLPIFISSVGFAWILGAAAGKALEPFGDKAGTAAALLGLFQMSGAGL"
     CDS             3467..3748
                     /locus_tag="ctg2_2797"
                     /transl_table=11
                     /translation="MSLTTYEMARILEQMEESPEKVMFGKLLNELGNQSSERVRSAAKQ
                     VPLPILRDLVYQFQQVIESRKGEQVEQMAKDLAQQGISAEELLAYLNK"
     CDS             complement(3780..4235)
                     /locus_tag="ctg2_2798"
                     /transl_table=11
                     /translation="MTDTVKNLVNRYDDLISTLQAGFVPLLLLFCRLWVAWVFFNSGLI
                     KISSWDSTLYLFELEYQVPLLPWELAAYLGTAAELVLPVFLALGLITRPMAAILFVFNI
                     IAVVSYPLLWEKGFYDHQLWGLMILVVIVWGPGPLSLDHILKKKITN"
     PFAM_domain     complement(3912..4157)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2798_0047"
                     /evalue="7.60E-18"
                     /label="ctg2_2798"
                     /locus_tag="ctg2_2798"
                     /protein_end="108"
                     /protein_start="26"
                     /score="65.0"
                     /tool="antismash"
                     /translation="LLLFCRLWVAWVFFNSGLIKISSWDSTLYLFELEYQVPLLPWELA
                     AYLGTAAELVLPVFLALGLITRPMAAILFVFNIIAVV"
     CDS             complement(4246..5004)
                     /locus_tag="ctg2_2799"
                     /transl_table=11
                     /translation="MNLATLQSQFAKALHYQAVGEDCDIASDEFTADERMQIYRNNFIV
                     SLSEVLSATYPMVEALLGEECFEQMARQHVLSYPLEEGNVVHYGEGFQDTIMQFSQVIA
                     QAPYSPEVARFEWHIDLARQAQYEQSNAQELKSLALLGEVSEEQQPALVLHLKQGCRSF
                     DSNYAVFDLFSAIQTGQFEQLNINQLQQGVISIQANGEALCHALDADVFQLLQCLEQKL
                     SLSEIPEVLLAHLNSIMALDLVDGFTLKSI"
     PFAM_domain     complement(4723..4989)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2799_0048"
                     /evalue="3.30E-22"
                     /label="ctg2_2799"
                     /locus_tag="ctg2_2799"
                     /protein_end="94"
                     /protein_start="5"
                     /score="78.6"
                     /tool="antismash"
                     /translation="LQSQFAKALHYQAVGEDCDIASDEFTADERMQIYRNNFIVSLSEV
                     LSATYPMVEALLGEECFEQMARQHVLSYPLEEGNVVHYGEGFQD"
     CDS             complement(5001..5873)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_2800"
                     /sec_met_domain="DUF692 (E-value: 2e-88, bitscore: 293.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKHHTFHDLVGVGLRTPHLDYFNQNKPELTWLEIHSENYFQPNAA
                     ERLQLQALREKYQISCHGIGLSLGSVERVNQKHLAQLKALIDSIDPILVSDHLSWSENG
                     GHYFNDLLPLPYTEEALKVFTRNVNEVQDYLQREILIENPSSYVKFQHSTISEWEFLTE
                     VQKRTDCRLLLDLNNVYVSAFNHGFDCDTYLDAIPADKVDEIHLAGFTIKQLDKGEIWI
                     DTHSRPVSDEVWQLFAQWTKKHGPRHALIEWDLDIPAPEVLLGEAHKASQVLLQGTIPS
                     EQSESRKAS"
     PFAM_domain     complement(5055..5846)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2800_0049"
                     /evalue="1.10E-105"
                     /label="ctg2_2800"
                     /locus_tag="ctg2_2800"
                     /protein_end="273"
                     /protein_start="9"
                     /score="352.7"
                     /tool="antismash"
                     /translation="VGVGLRTPHLDYFNQNKPELTWLEIHSENYFQPNAAERLQLQALR
                     EKYQISCHGIGLSLGSVERVNQKHLAQLKALIDSIDPILVSDHLSWSENGGHYFNDLLP
                     LPYTEEALKVFTRNVNEVQDYLQREILIENPSSYVKFQHSTISEWEFLTEVQKRTDCRL
                     LLDLNNVYVSAFNHGFDCDTYLDAIPADKVDEIHLAGFTIKQLDKGEIWIDTHSRPVSD
                     EVWQLFAQWTKKHGPRHALIEWDLDIPAPEVLLGEAHKASQV"
     CDS             complement(5959..6219)
                     /locus_tag="ctg2_2801"
                     /transl_table=11
                     /translation="MKKSNLAVTAAVTGLLALGGTMLTAAPAVAAEKEKCYGVSKAGKN
                     DCATKSSSCAGTAKEDNQKDAFVVVPKGLCDKLAGGSTTSS"
     PFAM_domain     complement(5974..6123)
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2801_0050"
                     /evalue="1.70E-22"
                     /label="ctg2_2801"
                     /locus_tag="ctg2_2801"
                     /protein_end="82"
                     /protein_start="32"
                     /score="79.3"
                     /tool="antismash"
                     /translation="KEKCYGVSKAGKNDCATKSSSCAGTAKEDNQKDAFVVVPKGLCDK
                     LAGGS"
     CDS             6500..8674
                     /locus_tag="ctg2_2802"
                     /transl_table=11
                     /translation="MMDPSLLLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIA
                     WLMSVEQASPFSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYL
                     DAKLPEDFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAY
                     HDPVTKTYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDE
                     FQDTNNIQYAWLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLE
                     QNYRSTKTILEASNALIANNTERMGKELWTDGVVGEPISVYSAYNELDEARFTVNKIKE
                     WQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYMRLI
                     ANRNDDAAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWEASVAMLDEKVLAGRAAGA
                     LSRFIELVTALEDDTIEMPLHHQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTAT
                     RQFEKPEEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGV
                     EEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIR
                     ELPETCLDEVRMKAQVSRPASSGRFSQTAVKESFNETGFTLGSRVMHPKFGEGTIINFE
                     GSGPQSRVQIAFNGEGIKWLVTAYARLEKL"
     aSDomain        6518..8665
                     /aSDomain="TIGR01075"
                     /aSTool="tigrfam"
                     /description="uvrD: DNA helicase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_2802_0016"
                     /evalue="0.00E+00"
                     /identifier="TIGR01075"
                     /label="ctg2_2802"
                     /locus_tag="ctg2_2802"
                     /protein_end="722"
                     /protein_start="6"
                     /score="1325.4"
                     /tool="antismash"
                     /translation="LLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVE
                     QASPFSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYLDAKLPE
                     DFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAYHDPVTK
                     TYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNN
                     IQYAWLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLEQNYRST
                     KTILEASNALIANNTERMGKELWTDGVVGEPISVYSAYNELDEARFTVNKIKEWQDKGG
                     ALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYMRLIANRNDD
                     AAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWEASVAMLDEKVLAGRAAGALSRFIE
                     LVTALEDDTIEMPLHHQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTATRQFEKP
                     EEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGVEEGMFP
                     SQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIRELPETC
                     LDEVRMKAQVSRPASSGRFSQTAVKESFNETGFTLGSRVMHPKFGEGTIINFEGSGPQS
                     RVQIAFNGEGIKWLVTAYARLE"
     PFAM_domain     6530..7315
                     /aSDomain="UvrD-helicase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00580.23"
                     /description="UvrD/REP helicase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2802_0051"
                     /evalue="5.20E-74"
                     /label="ctg2_2802"
                     /locus_tag="ctg2_2802"
                     /protein_end="272"
                     /protein_start="10"
                     /score="249.7"
                     /tool="antismash"
                     /translation="LNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVEQASP
                     FSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYLDAKLPEDFQI
                     IDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAYHDPVTKTYLQ
                     LYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNNIQYA
                     WLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEF"
     PFAM_domain     7331..8350
                     /aSDomain="UvrD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13361.8"
                     /description="UvrD-like helicase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2802_0052"
                     /evalue="7.30E-83"
                     /label="ctg2_2802"
                     /locus_tag="ctg2_2802"
                     /protein_end="617"
                     /protein_start="277"
                     /score="279.0"
                     /tool="antismash"
                     /translation="IRLEQNYRSTKTILEASNALIANNTERMGKELWTDGVVGEPISVY
                     SAYNELDEARFTVNKIKEWQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGM
                     RFFERQEIKDALSYMRLIANRNDDAAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWE
                     ASVAMLDEKVLAGRAAGALSRFIELVTALEDDTIEMPLHHQTDHVIKYSGLFAMYEQEK
                     GEKSKARIENLEELVTATRQFEKPEEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLM
                     TLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAE
                     "
ORIGIN
        1 atgcctgcga tttcaactgc gttcttcgct gcttttggca ttaggcatgg gtcagcttta
       61 ctcaccactg atgcgccagc attttgtaga accagcttaa accatgcgtt acttgtcgca
      121 gggtcaacca gtacattctt gccagttaga gtttctagtc gcgcttgcaa tgcttctggg
      181 tgatgaaccg tcacgccagc accaacgtga gcgtcaaact cagcaggtag gcgagctgga
      241 tctaggaagt attccacgct tgaatctgag tgtagaatcg cgtgagaaag cagaaccgga
      301 agacgtgata catctagacc acgaacgttg agcagccaac agatagaatc aagtgctgtg
      361 atcactgcgc tgtctgcacc ggcttttttc acgagctctg cgatttcttg acgtttgctt
      421 tcacttgatt gaccaactgc ttctgttgcc attaggcgaa catcagaaac cacaggagca
      481 gggcggtcgt gccacagctc atcaattggg ttgctgtcga gaaccttaag ctcaagtgca
      541 cctgcaagtt ttgcctgtgc catgtcgagc caagcagagt tgtgcatgcg agggtcgatt
      601 gcaacagacg cgccatttgc aagatggtct ttaatccaat ctagcgcagg ctcttcaatc
      661 aggtggcggt attcgaatag atcagcagga acctgcttag tgacttgtac cgtgtagcga
      721 ccatcaacaa agatagcggc tttgtctttg gtgattaccg cagcaccagc agaaccggta
      781 aaaccagtta gccaatgtaa acgctcgttg tgcgccggta cgtattcgcc caagtactcg
      841 tcttcatgtg ggataagtag ggcatcaata ttatgttgtg ctagccattc gcgaattgca
      901 ttcacgcggc ttagggtatt gttgtgcatc tgtgttattc cttcaaatta ccgctccttc
      961 atgctcaggt gtgggagctg tttccatctg cttcatgcag tttttgagtc cattgaggtt
     1021 cgcaatcact tcaatagagc cggagtacaa caggccatag atgagccaaa aaggactatc
     1081 gactgttaag ctactcatat tacattaata gagcaaattg cgttcaggat ttttatctaa
     1141 gatgattggt ttttttcgtg atcatggtac gcaaccaagt caaagctggg tcattctctc
     1201 tgtctcggtg ccagaacaaa gtgtaagcca ttggagggaa ttcgagtgga agaggcagca
     1261 atgccatgtc atgttgtttg gctgccagct tcacaaagtg gcttggcgcg gtgaacacaa
     1321 aatcggtgta agagcataaa ctggcggcgc tgttaaagtc cgggacggtt accgcaatat
     1381 cacgttcacg accaatgtcg gctaaacgat agtcgagcaa ccaacggtcg ttgccatcac
     1441 aacgtacctg aacatgacgc agggctaggt aagcttctaa gttccaatta ccactcaaag
     1501 ccgggtggtc tttacgtacg atacacatct ggtggtcgcg atagatttcc tgttcgcaaa
     1561 tgtcatctgg cggcaacatg gttagcttgg cgtcgttgat gtcgatatct cgacctgtca
     1621 tgcccaaatc gatctcacca cgctgaatca tcttgaacgt ttgttccgac caagagtggg
     1681 tactgatggt cacgcctggc gcttgttgga atattgccgg taagaagtgg ggcagaatca
     1741 acgggtagac actctctacc gcagctattt gaaagcggta ctcgctgctc tgtggtgaga
     1801 actcttcggg ttgagtcagc acctcaagtt ggtttatcaa cagatccagt ttcggtttaa
     1861 ggaacagtgc gcgtggtgtt ggcgtcaatc cgtgtgagtt tcgagtgaat aggggatcat
     1921 caaattgggt acgtaatttc gctaaggatt tgctcacggc agactgactc aagcacagtc
     1981 ggtgggcggc tcgggtaaca ttcaactctt caatcagcac tttaaaacag accagcaaat
     2041 tgaggtcgat acgtgccagt ttctctacgt tcacagtgat tttccccatt ggaataatgg
     2101 tcatgagtat acatcatttc cattcatatc atcagatgat taagctttgc tcaaaagttc
     2161 ttgttcaatt tggagtgttt tgtgtctagc catattacaa atagcaaaaa acagatggcg
     2221 ctgttgacca tgttagttct attcagtccg cttgcgattg atatctatct acctgctttg
     2281 cctcttatcg cgtccacttt tcaggtagaa aatgcattgg cacaagacac catcacttgg
     2341 ttcctatttg ctatgggtgt tggtcagctg ttcgctggtc ccttggcaga taaactcgga
     2401 cgtcgaactg ttgcattggg cggcatcacc atctacgcat tgagtgcttt attggcgtgg
     2461 agtgctcaaa atattgagtg gatgttgatg gctcgtttgc tacaaggctt aggtgcgtgt
     2521 gcaacatctg tagcagcctt tgcaacagtt cgcgatatct ttggtccgga gaaaagcggc
     2581 aagatgatca gctaccttaa cggtgcgatc tgctttattc cggcattggc accgattctt
     2641 ggtagctggt taacccaaca atttgattgg cgtgcaaact tcagctttat ggccggtttt
     2701 gctgtgattg cgggggcgat gatgttcctt ggaatgaagg aaaccaatcc tgcaacagaa
     2761 aagcaggcgg tatttaaact gagccgctac tgggcagtat tgagcacccc atcattcatc
     2821 ttccacgcat cactgtgttt gatggcgatg gcagttattc ttgcttacgt aacgtctgca
     2881 ccagtggtgc tgatgaccgg aatgggctta tcgatgaatg aattcacctt ctggtttggt
     2941 ctcaacgcgg cgtttaacat tgctgcttgt atgcttgcgc ctaagtttat ggatcgctgg
     3001 ggcacgcata actcacttgt ggttggtatc agcttactgg caattgctgg cgtgatcatg
     3061 atggtgatga aagagcacta caccgcgctg tctttcatgc taccaatttt catttcatcg
     3121 gttggcttcg cttggattct tggtgccgct gcaggtaaag cactagaacc gtttggagat
     3181 aaagcgggta cggctgcagc gttactcggc ttgttccaaa tgagtggtgc tggcttgttg
     3241 gtgggtacgc tacagcgtct atcgcttgac ccacaaacac tgattgcaat tcatatgtgg
     3301 gtgctgcttc ctgctttgct gatcctgttc agtaaagctg gtaagaagtg gcatgctaaa
     3361 ttagcgaatg cgtaaaactc ggtaatttag tattttccaa tgtacctaac gcgtgtatat
     3421 ttgtcgttca aactattctc gacaccataa cggaactcat aaagtaatgt cgttaaccac
     3481 gtatgaaatg gctcgtatct tagagcaaat ggaagaatca cctgaaaagg tgatgtttgg
     3541 caagttgctt aacgaattag gtaaccagag ctcagagcgt gttcgtagtg cggcaaagca
     3601 agttccactg ccgattttgc gtgatcttgt gtatcagttt caacaagtga ttgagtcacg
     3661 taaaggcgag caagtagagc aaatggcaaa agacctcgct cagcagggta tctcagcaga
     3721 agagttacta gcttacttaa acaaataata aaaaatcccc gcttcatgcg gggatttttt
     3781 tagttggtaa ttttcttctt cagtatgtgg tcgagagaca gtggtcctgg cccccacaca
     3841 atcacaacaa gaatcatcaa tccccaaagt tggtgatcat agaaaccttt ctcccacagc
     3901 agtggataag agaccacggc gatgatgttg aacacaaaca gaatcgcagc catcgggcgg
     3961 gtaattaacc ctagtgccaa gaacaccggt agaactaatt ccgccgccgt acctaagtaa
     4021 gccgccaatt cccatggcag taagggcact tggtattcca attcaaacaa atacagcgtg
     4081 ctatcccagg acgagatctt gattagccct gaattgaaga atacccatgc aacccacaag
     4141 cgacaaaaga gaagtagcaa agggacaaag ccagcttgta gggtactgat taaatcgtcg
     4201 taccggttca ctaagttttt aaccgtatcc gtcatagagt gctccttaga ttgatttcaa
     4261 tgtaaagccg tcaacgagat cgagtgccat gatgctattg agatgagcga gtaaaacttc
     4321 aggtatttcg cttaaactca gcttctgctc taaacattgc agcagttgga acacatcggc
     4381 atcgagtgcg tgacacaagg cttctccatt ggcttgaatc gagatgacac cttgctgtaa
     4441 ttggttgata ttaagttgtt cgaattgccc agtttgaatc gcactaaaca aatcaaatac
     4501 ggcgtagtta gagtcaaagc tccggcagcc ttgcttaagg tgcaaaacca aagcgggttg
     4561 ttgctcttca ctcacttcgc caagtaatgc gagcgatttt aattcctgtg cattggattg
     4621 ttcatactgc gcttgacgag cgaggtcgat atgccactcg aagcgtgcga cttcagggct
     4681 gtaaggtgct tgtgcgatca cctgactgaa ctgcatgatg gtgtcttgaa agccttcgcc
     4741 ataatgaact acatttcctt cttctaatgg gtaagagagt acatgttggc gagccatctg
     4801 ttcaaagcat tcttcaccaa gcagcgcttc gaccatcggg taagtcgcgg ataacacttc
     4861 gcttaggctg acgataaaat tattgcgata aatctgcatg cgttcatcag cggtaaactc
     4921 atcactggca atatcgcaat cttcaccgac tgcttgatag tgtagggctt tagcaaactg
     4981 gctttgtaag gtggctagat tcatgatgcc ttcctcgatt cgctttgttc acttgggatt
     5041 gtgccttgca acagcacttg cgatgctttg tgtgcttctc cgagcaagac ttctggcgcg
     5101 gggatatcca agtcccattc aatcaacgca tggcgtggac cgtgtttttt tgtccactgc
     5161 gcgaacagtt gccaaacttc atcactaact gggcggctat gggtatcaat ccatatctca
     5221 cctttgtcga gttgtttgat ggtaaaacct gccaagtgaa tttcatccac tttgtcggct
     5281 ggaatcgcat ctaggtatgt gtcgcaatca aaaccgtggt taaacgccga aacataaaca
     5341 ttgtttaaat cgagcaataa acgacagtcg gtgcgctttt gaacttcggt cagaaactcc
     5401 cattcactaa tggttgaatg ttgaaacttc acataactag atgggttctc tatcaagatc
     5461 tcgcgttgca aataatcctg cacttcattc acgttacgag tgaacacttt gagtgcttct
     5521 tccgtgtatg ggagtggaag taagtcgtta aagtagtggc cgccgttttc actccaactt
     5581 aaatggtcag aaacaagaat cggatcgatt gaatcgatca gtgctttcag ttgcgctaaa
     5641 tgtttttgat tcacacgctc caccgaacct aatgacaaac caatgccgtg acagctaatt
     5701 tggtatttct cgcgcagtgc ttgtagctga agacgttctg cagcattggg ctgaaaatag
     5761 ttttcactgt ggatttctaa ccaagttaac tcaggtttgt tttggttaaa gtaatcgagg
     5821 tgaggggttc ttaatccaac gccaacaagg tcatggaagg tgtggtgttt cacgtgaaac
     5881 tccttttcaa aacgggcggt aagaggagga tgcattggtg agcgtcaacg catcctcata
     5941 gcagctagcg atgaaagatt atgaagaagt agtgctacca ccagctaatt tgtcgcatag
     6001 acctttagga acgacaacaa acgcgtcttt ctggttatct tctttagcag tacctgcaca
     6061 tgagctgctt ttcgttgcac agtcgttttt gcctgcttta gaaacgccgt agcacttctc
     6121 tttctcagca gcgacagctg gagctgcagt tagcattgtg ccaccaagag ctagaagacc
     6181 agtaacagca gcagtaacag ctagattcga ctttttcata ataaattcct ctgaatgatt
     6241 tccttcactt taatttggca agatgaatcg cctgttttgg cgtttttgtt ctcaacttgc
     6301 ttaacttaaa agataggaaa ttggctaaaa aactttcaga gaaattttcg aaacaaatga
     6361 ttttaaagag tgtgatttat ataacttatt gatgtttgga gtaaaaaaac gacgaatttt
     6421 ttatgaattt ttgtctaatc tgaacaggtt gtttaggtta taatctattt ttatgtataa
     6481 ataaccagta gctctcatca tgatggatcc atctctatta ctcgacggtt tgaacgataa
     6541 acaacgtgaa gccgttgcag cacctttaga aaacttgctc gtccttgctg gtgcagggag
     6601 tggtaagaca cgcgttcttg ttcaccgtat cgcttggttg atgtcggtag agcaggcttc
     6661 tccgttctca atcatgtcgg taacctttac caataaggcg gcggcagaga tgcgtggacg
     6721 tatcgaagag ctaatgatgg gcagtgcagg cggtatgtgg aatggtactt tccacggcat
     6781 ttgtcaccgc attctgcgtg cgcactatct tgatgccaag ctaccggaag atttccaaat
     6841 catcgacagt gacgaccaac agcgtctact aaagcgtttg atcaaagcgc aaaaccttga
     6901 tgagaagcag tggccagcac gccaagtggc atggtggatc aacggtaaga aagacgaagg
     6961 tctgcgtccg tcgcatattg atgcgtacca tgatccagtg accaagacat atctgcagct
     7021 gtacaccgct taccaagaag cgtgtgatcg tgctggttta gtcgattttg cggaaatctt
     7081 gctgcgcgca catgagctac tgcgtgataa caaattcgtc cgtgaacact accaagcacg
     7141 ctttaagcat atcttggtgg acgagttcca agataccaac aacattcaat atgcttggct
     7201 acgtatgatg gcgggtcctg agtgtcacgt gatgatcgta ggtgatgacg accagtcgat
     7261 ttacggctgg cgtggtgcaa aagttgagaa cattgagaag tttacgctcg aattcccaag
     7321 cgtgaatacc attcgtcttg agcaaaacta ccgttcaacc aagaccattc tggaagcgtc
     7381 caatgccctg attgcgaata acaccgagcg catgggtaaa gagctttgga cagatggcgt
     7441 tgtcggtgag cctatctcgg tttacagcgc ttacaacgaa ttggatgaag cccgttttac
     7501 ggtaaacaaa attaaagagt ggcaagacaa gggcggtgct ctgaatgatg ctgcgatgct
     7561 ttaccgtaac aacgcccagt cgcgtgttct ggaagaagcc ttgattcaag ctggtttgcc
     7621 ttaccgtatc tacggcggca tgcgattctt cgaacgtcag gaaatcaaag atgccttgag
     7681 ctacatgcgt ctgattgcca accgtaatga tgatgcggca tttgaacgtg tagtgaatac
     7741 gccaacgcgt ggcttgggcg acaagacgct tgaaaccatt cgctttgcgg ctcgtgatcg
     7801 tggttgtacc atgtgggaag cgagtgtcgc gatgttggat gagaaggtac ttgcaggtcg
     7861 tgctgctggt gctctgagcc gttttatcga gcttgttacg gcactagaag acgacaccat
     7921 cgagatgccg ctgcaccacc aaactgacca tgtgattaaa tactcgggct tgttcgcgat
     7981 gtacgagcaa gagaagggcg aaaagtctaa ggcgcgtatt gagaacttgg aggaattggt
     8041 gaccgcaact cgccaattcg agaaaccaga agaagccgag gacatgtcac tgctgacggc
     8101 attcctaacc catgcggcac tagaagcggg cgaaggacaa gcggacgagt ttgaagatgc
     8161 ggttcagctc atgacattgc acagtgcgaa aggtctagag ttcccattgg tgtttatggt
     8221 tggtgtggaa gaaggcatgt tcccaagcca aatgtcggca gaagaagcag ggcgtttaga
     8281 agaagaacgt cgtctgtgtt atgtcggcat gacccgtgcg atgcagaaac tgtacatcac
     8341 ttatgctgaa atgcgtcgct tgtacggtca ggataagtat cataagccgt ctcgctttat
     8401 ccgtgaactg ccagaaactt gcttagacga agtacgcatg aaggcgcaag ttagccgtcc
     8461 cgcaagcagt ggtcgattta gccaaacggc ggtgaaagag agcttcaatg aaactggctt
     8521 tacgctaggt tctcgtgtga tgcatcctaa gtttggtgag ggcaccatca tcaacttcga
     8581 aggcagtggt ccacagagcc gtgtacagat tgcctttaac ggtgagggca tcaaatggtt
     8641 ggtgactgct tacgctcgac tagagaagct gtaaggtcat caacttaaga gctgcttcgg
     8701 cggctctttt tgttggtgct gtttgtatgt cgctaatgca gtaaaaaatg gcgtgcgaaa
     8761 gcgcgattta acggtgcagc tgagaaaaat tttaggcaaa gaaaaacccc gagggcttgc
     8821 gcccatcggg gttatagtct tactcgcagc aatccggcta ctaagagtgc tccatgcatc
     8881 taatccatga tagtgtgctg aatccgtcag cttaatcctt acgtcgcctt cctagcggtg
     8941 tccttaatga ccttatcctg gtctgctaac catcctcgtt agctctcatc acttgttccc
     9001 tgagcggtgt ccctgacatc atcctgatgt tcaaatcctt gcctcgtcca gaggtgtcca
     9061 tttcccgtcc ttagtagcaa ccatcctagt cactattgat tccgttcaat gtccaatttt
     9121 gcaatccatg cccgactatt catcctgaat aaccgtttct tcttcctgaa gttcaccaag
     9181 tccgtggtgt ttcctgttcc atgtcagcat ccttccgaca ggtttaatat tacgtgttta
     9241 actgtttcca acaacggaca aatctcacat ttttttactc tcttagcgtt caaaaaagat
     9301 acataaccat ttaaatcaat agcttatggg tttgtgtgcg cagttttgcc attaaaaaag
     9361 agaggtttgc tcaacccttt gtgagagatc tcgcacaagg ggtcgagcga aagactctta
     9421 ctgcccgata gcggcacctt cacgccttgg atcggctgcg ccctcaagac cgtcttttgt
     9481 tatacgtatc gcatgcagtc cagagttcaa atcacgaaca tcagttttaa aacccatctt
     9541 ttccaactca ggctgtaagc cttctgcagc agtaccttgc tcaatatcta aggtaccaaa
     9601 acggttcagt aatcgtggtt gattaatcgc gctttggatg tccatatccc attgcgtgtg
     9661 ggcgataatg gcttgtgcga cgtaaccaat gatgcggctg ccacccggtg agccaattgc
     9721 catgtaaggt ttgtcgttct tcatcataat ggttggtgcc atggatgaac gtgggcgttt
     9781 gcccggttct aagcggttcg cgattggcac tccatcttga tgagtgcgga aagagaaatc
     9841 agtcagttcg ttattgagca agaagccacg caccatcaag cgtgagccaa aggcgttctc
     9901 aatagttgtt gtcattgaaa ccacattgcc ttgcttatcg acgatattga aatggctggt
     9961 ggaaggcagc tcgattgatt ggtccatgct taggttcatc gcgtgtgacc acggtggatt
    10021 gccggcttca accttacgca aggctttacc gacttgaatc aactcagcac gctgttttag
    10081 atagtcttta tcaagcaagc cttcggttgg cattggcaca taatcttggt ctgccatgta
    10141 tttaccgcga tccgcaaacg caaggcgaga cgcgtcggcg atcacttgcc atgatttcgc
    10201 gctttcggct ccccaacctt taagatcgta gtgctcggtg atcgcaagaa tctgtccaac
    10261 cgtcagtgcg ccagagctag gtggtcccat gccgcagatg tcatagcttt ggtaagccgc
    10321 acaaaccggt tcacgttgtt tgatttggaa cgcatcaaag tcaggttgtg ccaatacgcc
    10381 aggattgccc ggtgcattct gtactgtctt gatgatgtct gtggcgatat cgccttgata
    10441 gaaagctttt gctccttgct ctgcaattgc cgtcagagtt tgcgcgtatt cagggttctt
    10501 caacaacgtg ccttcggctt ttggtgagcc atctggatta aagaagtaag ctttagtcgc
    10561 agggaagcgt gatagacgct tggcatcttt ctcaatcaga ctcgcgaggc gaggacttac
    10621 ttcgaaacct tgctcagcca aggtaatcac aggttggatg atctttttcc attccaactt
    10681 gccgtatttc tggtgcgtgt cccacagtag tttcactgtg ccaggagtag caacggagcg
    10741 ccctccgaca accgcatcgt aaaattgcag tggttgtcct ttgtcatcta ggaagagttt
    10801 cggcgtcgcg gcgagcggtg cggtttcgcg cccatcatac gtagtcagtt tttgtttctc
    10861 actgtcccaa tac
//
