LOCUS       NZ_CP016022.1          11887 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP016022.1 Ralstonia insidiosa strain ATCC 49129 chromosome 1,
            complete sequence.
ACCESSION   NZ_CP016022
VERSION     NZ_CP016022.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:04:31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1565896
            Orig. end    :: 1577783
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11887
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[1570896:1572783](+)"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6887
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="siderophore"
                     /protocluster_number="1"
     cand_cluster    1..11887
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11887
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="siderophore"
                     /region_number="4"
                     /rules="IucA_IucC"
                     /tool="antismash"
     CDS             1782..3149
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 389;
                     E-value: 4.1e-118)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1496"
                     /transl_table=11
                     /translation="MESEVHDFIAIGLGPFNLSLSCLAEPIADLNGLFLERAPEFNWHP
                     GMLIDNTTLQNPFLADLVSLADPKSRFSFLNYCKQEGKIYSYYFRENFYLSRAEYNRYC
                     KWVVAQLTCARFHHDVQALAYDAQRGCYVVSGFRGAECEPFVLRARKLVLGVGSSPSFP
                     ACVRRDGHRYLHTADYIDVRESLHEKRSITIVGSGQSAAEVYYDLLKESDKHDYRLVWI
                     TRSPRFFPMETTKLTLEMFSPDYIDHFYSLPDGRKDAIVRAQDSLYKGVNTSLINQIYD
                     LLDDKRKVGELRTHLITNCELQACRHDAATGTYEIEFQQVDSGARYAHRTEGLVLATGY
                     EQNIPAFLDGIRHRLRWDAKGRYQLSRNYAADVNGSEVYVQNAGLHTHGVTNQDIGMSC
                     YRNSYIIRELTGVEHYKIEPRVAIQDFAIPATPEFIPLAAERSITERVKEPIEEAV"
     PFAM_domain     1791..2804
                     /aSDomain="K_oxygenase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13434.8"
                     /description="L-lysine 6-monooxygenase (NADPH-requiring)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1496_0083"
                     /evalue="1.20E-112"
                     /label="ctg1_1496"
                     /locus_tag="ctg1_1496"
                     /protein_end="341"
                     /protein_start="3"
                     /score="376.5"
                     /tool="antismash"
                     /translation="EVHDFIAIGLGPFNLSLSCLAEPIADLNGLFLERAPEFNWHPGML
                     IDNTTLQNPFLADLVSLADPKSRFSFLNYCKQEGKIYSYYFRENFYLSRAEYNRYCKWV
                     VAQLTCARFHHDVQALAYDAQRGCYVVSGFRGAECEPFVLRARKLVLGVGSSPSFPACV
                     RRDGHRYLHTADYIDVRESLHEKRSITIVGSGQSAAEVYYDLLKESDKHDYRLVWITRS
                     PRFFPMETTKLTLEMFSPDYIDHFYSLPDGRKDAIVRAQDSLYKGVNTSLINQIYDLLD
                     DKRKVGELRTHLITNCELQACRHDAATGTYEIEFQQVDSGARYAHRTEGLVLATGYE"
     CDS             3146..4393
                     /gene_functions="transport (smcogs) SMCOG1184:major
                     facilitator transporter (Score: 41.1; E-value: 1.5e-12)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1497"
                     /transl_table=11
                     /translation="MTLRNTIILMTVFAVISDAILIPFYPQFFASRYGLDSPVHVGAYV
                     AAISITVMCTLPLWARVAKRVEPLYLLVYTQFAAGTFSLLSDWAPNVVTYWVLSMLMFM
                     CKSSYLLMYPYMMRLTPKAQHAATVGTLSVVVHFGAIFGAVVGGLVLQTWGPRASIVAM
                     AAGDFFQMGVCMHLIRSGKIVRVNSGEHAEAAAAEAARVPRTGWRDRLPILRLALVMLV
                     FDFSAYLIRPFFSVYWQQVSGLDSEFVSGMAFAIPGVVAIVALRLHARIRARGGQLPDH
                     TVGNLLLGMVGLLLHAAPNPMLIVLGRVLYGWALFQIIVKLEVNLFRLSTPQRYAHDYS
                     ITNFFQNMGVLLSSFAAGAIVNRYGLHLPFLLAAGGFVLTAVLDRLILNVPSAGHADDS
                     GRAEAPANLEAPVHAN"
     PFAM_domain     3164..3940
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1497_0084"
                     /evalue="9.40E-14"
                     /label="ctg1_1497"
                     /locus_tag="ctg1_1497"
                     /protein_end="265"
                     /protein_start="6"
                     /score="51.2"
                     /tool="antismash"
                     /translation="IILMTVFAVISDAILIPFYPQFFASRYGLDSPVHVGAYVAAISIT
                     VMCTLPLWARVAKRVEPLYLLVYTQFAAGTFSLLSDWAPNVVTYWVLSMLMFMCKSSYL
                     LMYPYMMRLTPKAQHAATVGTLSVVVHFGAIFGAVVGGLVLQTWGPRASIVAMAAGDFF
                     QMGVCMHLIRSGKIVRVNSGEHAEAAAAEAARVPRTGWRDRLPILRLALVMLVFDFSAY
                     LIRPFFSVYWQQVSGLDSEFVSGMAFAIPGVVAIVAL"
     CDS             4383..4985
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     128.6; E-value: 6.8e-39)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1498"
                     /transl_table=11
                     /translation="MPTDAHTIHRRADAESAPYTDADGFTFHLLRIPEDIPMLHRWFQP
                     ERASFWLMRDKTEAEVGQVYQNLMDSGHATAYLVWQGGRPVFLAECYDPAHDRIRTFYD
                     VQPGDLGMHIFIGPSDVHIAGYTRAVFFALMRFMFDRLGAARIVVEPDANNTRIHAINR
                     AAGFVYDRNVAFTEKIASLAFCTRQDFEQATSATAIA"
     PFAM_domain     4479..4904
                     /aSDomain="Acetyltransf_8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13523.8"
                     /description="Acetyltransferase (GNAT) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1498_0085"
                     /evalue="1.30E-44"
                     /label="ctg1_1498"
                     /locus_tag="ctg1_1498"
                     /protein_end="174"
                     /protein_start="32"
                     /score="151.5"
                     /tool="antismash"
                     /translation="PEDIPMLHRWFQPERASFWLMRDKTEAEVGQVYQNLMDSGHATAY
                     LVWQGGRPVFLAECYDPAHDRIRTFYDVQPGDLGMHIFIGPSDVHIAGYTRAVFFALMR
                     FMFDRLGAARIVVEPDANNTRIHAINRAAGFVYDRNVA"
     CDS             5001..6887
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1499"
                     /sec_met_domain="IucA_IucC (E-value: 1.3e-73, bitscore:
                     245.4, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVTIHNQLSQHPAQAAAHLTPEVWAQANRLLLRKAIAEYAHERI
                     LEPEYLHATAGGFALYQVFSDDGKVCYQFEAQQLALRHWFIQPESIRRLVEGAQQPLDA
                     LQFIIECRQRLGIRDELLPIYLDEISSTLFGSAFKRMKADAPSSAQLAEATDFQAIEVA
                     MIEGHPGFVANNGRLGFTSVDYQAYAPEAGSDIRVIWLAVHKDHATPSTLSTLNYAQML
                     AEELGQDTVDDFTRQVAEKGVDSADYHFMPAHPWQWFNKLSIAFAGYVAQRKIICLDYS
                     ADHYIAQQSIRTFFNTSDRTKRYVKTSLSILNMGFMRGLSPYYMSGTPAINEFIKELVS
                     KDGFLRENGFTILQEVAAIGFRNFYYEAAIPVDTPYKKQFSALWRENPLPLLKPGERLM
                     TMAALLHVDKDGHALMPELIRRSGLPALTWVRQYLQVYLTPLLHCFYAYELTFMPHGEN
                     LILVMDNHVPVRAIMKDIAEECAILDIKAREWLPERVQRLAVEVPDNFKLLGIFIDVFD
                     GVLRHINHVLVENACCTEDQFWGAVADCVYDYQDAHPEHAAKYAHYDMFVPEFLHSCLN
                     RLQLGNNVQMVNLADPASSLKIAGNLVNPIARFRRAAPAVHAEATDAVEAAA"
     PFAM_domain     5466..6218
                     /aSDomain="IucA_IucC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04183.14"
                     /description="IucA / IucC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1499_0086"
                     /evalue="8.20E-71"
                     /label="ctg1_1499"
                     /locus_tag="ctg1_1499"
                     /protein_end="406"
                     /protein_start="155"
                     /score="238.4"
                     /tool="antismash"
                     /translation="DFQAIEVAMIEGHPGFVANNGRLGFTSVDYQAYAPEAGSDIRVIW
                     LAVHKDHATPSTLSTLNYAQMLAEELGQDTVDDFTRQVAEKGVDSADYHFMPAHPWQWF
                     NKLSIAFAGYVAQRKIICLDYSADHYIAQQSIRTFFNTSDRTKRYVKTSLSILNMGFMR
                     GLSPYYMSGTPAINEFIKELVSKDGFLRENGFTILQEVAAIGFRNFYYEAAIPVDTPYK
                     KQFSALWRENPLPLLKPGERLMTMAALLH"
     PFAM_domain     6282..6758
                     /aSDomain="FhuF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06276.14"
                     /description="Ferric iron reductase FhuF-like transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1499_0087"
                     /evalue="4.30E-33"
                     /label="ctg1_1499"
                     /locus_tag="ctg1_1499"
                     /protein_end="586"
                     /protein_start="427"
                     /score="115.1"
                     /tool="antismash"
                     /translation="TWVRQYLQVYLTPLLHCFYAYELTFMPHGENLILVMDNHVPVRAI
                     MKDIAEECAILDIKAREWLPERVQRLAVEVPDNFKLLGIFIDVFDGVLRHINHVLVENA
                     CCTEDQFWGAVADCVYDYQDAHPEHAAKYAHYDMFVPEFLHSCLNRLQLGNNVQM"
     CDS             6884..7702
                     /locus_tag="ctg1_1500"
                     /transl_table=11
                     /translation="MTDGMRAFVEDASGSGFALPQAWRSAPTPNPDLAHALRLAQRVIP
                     SLRGEQGGVSPANALRLGDDVALQALCDHWAQAYPEAGAHYLALRCWGLAIWQPIYLCV
                     IAVHLDGLAPRLAGLVQPVKAGFPSGFHLPVHAPVGGTFVGRMEAAAAELRAFCDAVRR
                     AIKPMVALHERAADRLQAECVLGALMAVRPHTSLSDADMTAIGEAWLVALGIAGGCGFF
                     AYRARDGTPALALDRKVCCHYFRRRDGEKCSTCPKLSLDARIARLLAEAS"
     aSDomain        6995..7654
                     /aSDomain="TIGR03950"
                     /aSTool="tigrfam"
                     /description="sidero_Fe_reduc: siderophore ferric iron
                     reductase, AHA_1954 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1500_0010"
                     /evalue="3.90E-50"
                     /identifier="TIGR03950"
                     /label="ctg1_1500"
                     /locus_tag="ctg1_1500"
                     /protein_end="257"
                     /protein_start="37"
                     /score="168.7"
                     /tool="antismash"
                     /translation="RLAQRVIPSLRGEQGGVSPANALRLGDDVALQALCDHWAQAYPEA
                     GAHYLALRCWGLAIWQPIYLCVIAVHLDGLAPRLAGLVQPVKAGFPSGFHLPVHAPVGG
                     TFVGRMEAAAAELRAFCDAVRRAIKPMVALHERAADRLQAECVLGALMAVRPHTSLSDA
                     DMTAIGEAWLVALGIAGGCGFFAYRARDGTPALALDRKVCCHYFRRRDGEKCSTCPK"
     PFAM_domain     7592..7654
                     /aSDomain="FhuF_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11575.10"
                     /description="FhuF 2Fe-2S C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1500_0088"
                     /evalue="7.10E-05"
                     /label="ctg1_1500"
                     /locus_tag="ctg1_1500"
                     /protein_end="257"
                     /protein_start="236"
                     /score="22.8"
                     /tool="antismash"
                     /translation="RKVCCHYFRRRDGEKCSTCPK"
     CDS             7788..8948
                     /locus_tag="ctg1_1501"
                     /transl_table=11
                     /translation="MTDVGRLAHVMPAHTQLPVAAYFDDALFACELETIFKQSACYIGN
                     EKAVPESGDWRRLAQEDGGRVLVRNAGGVELMSNVCRHRQALILGGEAGNVTGPANATG
                     NLGAAGGNIVCPLHRWTYTDRGELIGAPQFTSTPCKNLQRFTLRNCHGLLFEGPRDPAH
                     DMAPLFARPEFDFGDYVLDHVEVHQCNYNWKTFIEVYLEDYHVAPFHPGLGHFVTCDNL
                     EWEFADWYSMQRVGIHQALSQPGSDVYGAWHDRLLDYRSGTSPDFGAIWVTYFPTHMIE
                     LYPHVLVLSTLYPKGPQDTVNVVEFYYPEEIAAFEREFVEAQRAAYMETCIEDDEIGER
                     MDAGRRALMARGVSETGPYQSPLEDGMQHFHAWYRRIMGTLPVADV"
     PFAM_domain     7911..8192
                     /aSDomain="Rieske"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00355.28"
                     /description="Rieske [2Fe-2S] domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1501_0089"
                     /evalue="3.30E-09"
                     /label="ctg1_1501"
                     /locus_tag="ctg1_1501"
                     /protein_end="135"
                     /protein_start="41"
                     /score="36.6"
                     /tool="antismash"
                     /translation="YIGNEKAVPESGDWRRLAQEDGGRVLVRNAGGVELMSNVCRHRQA
                     LILGGEAGNVTGPANATGNLGAAGGNIVCPLHRWTYTDRGELIGAPQFT"
     PFAM_domain     8316..8921
                     /aSDomain="Ring_hydroxyl_A"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00848.21"
                     /description="Ring hydroxylating alpha subunit (catalytic
                     domain)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1501_0090"
                     /evalue="9.00E-32"
                     /label="ctg1_1501"
                     /locus_tag="ctg1_1501"
                     /protein_end="378"
                     /protein_start="176"
                     /score="110.8"
                     /tool="antismash"
                     /translation="GDYVLDHVEVHQCNYNWKTFIEVYLEDYHVAPFHPGLGHFVTCDN
                     LEWEFADWYSMQRVGIHQALSQPGSDVYGAWHDRLLDYRSGTSPDFGAIWVTYFPTHMI
                     ELYPHVLVLSTLYPKGPQDTVNVVEFYYPEEIAAFEREFVEAQRAAYMETCIEDDEIGE
                     RMDAGRRALMARGVSETGPYQSPLEDGMQHFHAWYRRIM"
     CDS             9025..11043
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103:FAD dependent oxidoreductase (Score: 107.3;
                     E-value: 1.6e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1502"
                     /transl_table=11
                     /translation="MPRGLVLATPQLTSDGTPFSAQYDDVYHSTEGGLAQAQHVFLGGN
                     ALPGAWQGKNAFTIVETGFGQGLNFLATWAAWRDDPQRCARLDFVSIEKHPFDRAGLSV
                     VHPKDGVLAPLGEALRQSWPVPVPGVHRLVFDEGRVTLTLLFGDAMEMLPQLSCAADAF
                     YLDGFSPAKNPDLWQPRVFKQLARVARAGATLATYTAAGFVRRGLQEAGFEAHKAPGFG
                     TKRDMTVAQFPTHWKTRRGPVEAPVWSERHAIVLGAGLAGCSVAERLAARGWRITLIDA
                     NEGPARGTSAHRAAAMHPHVSIDDSVLSRLSRAGNLLACRQWDALDRAGFATGFQPTGV
                     LQLAEHEDDAAEQQRVVQALGYPTGYIDWLSASQAAERVGAGVPQGGWWFGQAGWVAPP
                     DVCRANLAAAANATHAHWNTRVESLREAGGQWQALDAHGGVIASAPVVILANSLDAARL
                     APLSSASLKPVRGQLTDVPLVSLEPRAAWPRAVVCGDGYLLPAEPDAQSVRIGSSFQPG
                     DSDLAERAGDHAANLKRLASMQPQQSQALARLDPAQLHGYVGVRCVSANRLPLIGAVVD
                     EAVAMAPGFRLRGPHAQLPRVPGLYAALAYGSRGLTWSVLGAELLAAQIDGGPLPLEVD
                     LAAALDPGRFVLRALQHGHGRGQGAAPAETEAADTLD"
     PFAM_domain     9364..9720
                     /aSDomain="Methyltransf_30"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05430.13"
                     /description="S-adenosyl-L-methionine-dependent
                     methyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1502_0091"
                     /evalue="1.70E-43"
                     /label="ctg1_1502"
                     /locus_tag="ctg1_1502"
                     /protein_end="232"
                     /protein_start="113"
                     /score="147.6"
                     /tool="antismash"
                     /translation="PLGEALRQSWPVPVPGVHRLVFDEGRVTLTLLFGDAMEMLPQLSC
                     AADAFYLDGFSPAKNPDLWQPRVFKQLARVARAGATLATYTAAGFVRRGLQEAGFEAHK
                     APGFGTKRDMTVAQF"
     PFAM_domain     9778..10893
                     /aSDomain="DAO"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01266.26"
                     /description="FAD dependent oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1502_0092"
                     /evalue="3.40E-44"
                     /label="ctg1_1502"
                     /locus_tag="ctg1_1502"
                     /protein_end="623"
                     /protein_start="251"
                     /score="152.0"
                     /tool="antismash"
                     /translation="HAIVLGAGLAGCSVAERLAARGWRITLIDANEGPARGTSAHRAAA
                     MHPHVSIDDSVLSRLSRAGNLLACRQWDALDRAGFATGFQPTGVLQLAEHEDDAAEQQR
                     VVQALGYPTGYIDWLSASQAAERVGAGVPQGGWWFGQAGWVAPPDVCRANLAAAANATH
                     AHWNTRVESLREAGGQWQALDAHGGVIASAPVVILANSLDAARLAPLSSASLKPVRGQL
                     TDVPLVSLEPRAAWPRAVVCGDGYLLPAEPDAQSVRIGSSFQPGDSDLAERAGDHAANL
                     KRLASMQPQQSQALARLDPAQLHGYVGVRCVSANRLPLIGAVVDEAVAMAPGFRLRGPH
                     AQLPRVPGLYAALAYGSRGLTWSVLGAELLAA"
     aSDomain        9778..10980
                     /aSDomain="TIGR03197"
                     /aSTool="tigrfam"
                     /description="MnmC_Cterm: tRNA U-34
                     5-methylaminomethyl-2-thiouridine biosynthesis protein
                     MnmC, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1502_0011"
                     /evalue="8.30E-122"
                     /identifier="TIGR03197"
                     /label="ctg1_1502"
                     /locus_tag="ctg1_1502"
                     /protein_end="652"
                     /protein_start="251"
                     /score="405.0"
                     /tool="antismash"
                     /translation="HAIVLGAGLAGCSVAERLAARGWRITLIDANEGPARGTSAHRAAA
                     MHPHVSIDDSVLSRLSRAGNLLACRQWDALDRAGFATGFQPTGVLQLAEHEDDAAEQQR
                     VVQALGYPTGYIDWLSASQAAERVGAGVPQGGWWFGQAGWVAPPDVCRANLAAAANATH
                     AHWNTRVESLREAGGQWQALDAHGGVIASAPVVILANSLDAARLAPLSSASLKPVRGQL
                     TDVPLVSLEPRAAWPRAVVCGDGYLLPAEPDAQSVRIGSSFQPGDSDLAERAGDHAANL
                     KRLASMQPQQSQALARLDPAQLHGYVGVRCVSANRLPLIGAVVDEAVAMAPGFRLRGPH
                     AQLPRVPGLYAALAYGSRGLTWSVLGAELLAAQIDGGPLPLEVDLAAALDPGRFVLRAL
                     QH"
ORIGIN
        1 ggccttccgc gtgacaggct tgggacgcgg catggattct cagttccagc acgtgcggga
       61 agagcgcttt gccatcgcgc cgtcgttggc catcaacttc acgccgaaca cgcacctgtt
      121 gctgcaggcc tatctgcagc aagatccgga aggcagcttc aacagcggcg tgccggcgga
      181 gggcagcctg ttcccgcaca acggccgcac catctcgcgc tacttcttcg acggcgaccc
      241 gacagtcgaa aaattccgcc gcacccagcg catgctgggt taccagttcg agcacatgtt
      301 caatgacgcg tggacggcgc gccagaactt ccgatacatc tacggtgacg tgcgcatgcg
      361 ccagatctac ggctacggct gggccgatgc gaacaacctc acgcgctatt acgctggcgc
      421 caaggaggcc acgcacgcct acacggtcga taaccagctc gaaggcaagt tcacaaccgg
      481 ccccgtcaaa cacacgctgc tggttggcct ggattaccag aagcgccacg tcgatggctt
      541 ttgggaatcc ggcagtgcag acccgatcaa cgcattcaac ccggtctatg gcaatccggg
      601 tctgacgggt gtgacggcga cgccgataga ccgctggctg gagcagaccg gcgtgtactt
      661 gcaggaccag atcgccatcg accgctggcg cttcacactg ggcgtgcgtg aagaccacgc
      721 caaggcatcc aacctgtatg gcacgggcac cccgtcagag tggagcggct cgaagttcac
      781 caagcgtgcg ggcgtggtct acctgttcga caacggtatc gccccgtact tcagctatgc
      841 cgatggcttc aacccgagca tccggacgga ccagcggggc aatctgctgc aaccggccac
      901 ggccaagcag ttcgaggcgg gtgtgcgtta tcagcctaag ggctcgagca cgatgctgtc
      961 ggccgccgtg ttcaacctgg aacaggagaa catcgccaac cggccatctg cccaggtcta
     1021 ctacgtgccc actggcaagg tgcgtacgcg cgggctggaa ctggaggcgc gttcacagat
     1081 cacggataac gtttcgctgc tggccaacta cacgttcacc gacatgaagt ttgtcgagtc
     1141 caccgaaggc ttcgtgggca acacgccgta ccaggcgccg cgccatatgg catcggtgtg
     1201 gggcgattgg accttcatgc ccggctacac ggcgggtgtg ggggtgcgct acgttggcac
     1261 gagctatggc gacagcgcca acagcttcaa ggtgccgccg tacacactgg tcgatttgat
     1321 gctgcgtatc gatctcgcgc gctgggaccc atcgctcaag ggtgcaaagt tgcagttgtc
     1381 ggcaaagaat ctctttaata aagcgtatgt ggcatcttgc atgaacagca actactgcta
     1441 ttggggtgat gcgcgcagcg caatggcaac catttcgtat caatggtaat taagatttat
     1501 tcacgcaatc atcatcctgc ttgtgtagta ttgtgactta gcttgttgcc cggcggcttt
     1561 ttattgaagt cgtcgggcga gtcagcatct atcctgatat cgcatccgcg atattccatg
     1621 atccttcagc ggccggcacg catcggtcgt gatctgctcc ccacctgaat ttacctagtc
     1681 taggcgcggc ctgatgccgc cagccaacgg gaaacgtgtg cacgttcgct cggctggagt
     1741 cttgttgtca tcgcttttgt aaatcaggag gttcaaacgt gatggaatca gaagttcatg
     1801 actttattgc cattgggttg ggtccgttta atttaagcct gtcttgtctg gcggaaccca
     1861 ttgccgattt gaatgggtta tttctggagc gggcgccgga attcaattgg catcctggta
     1921 tgctgattga taacaccaca ttgcagaatc cattcctggc ggatcttgtc agtttggcgg
     1981 atccaaaaag ccgcttcagc ttcctgaatt actgcaagca ggaaggcaag atctattcgt
     2041 attacttccg cgagaacttc tacctgagcc gggcggagta caaccgctat tgcaagtggg
     2101 tcgtcgcgca gctcacctgt gcgcgcttcc accacgacgt gcaggcgctg gcctatgacg
     2161 cgcagcgtgg ctgctacgtg gtctcgggct ttcgcggcgc ggagtgcgag ccgttcgtcc
     2221 tccgtgcacg caagctggtg ctgggcgtgg ggtcgtcgcc gtcgttcccg gcgtgcgtgc
     2281 ggcgcgatgg ccaccgctat ctgcacaccg cggattacat cgacgtgcgt gaatcgctgc
     2341 acgagaaacg ctccatcacc atcgtcggca gcgggcaaag cgcggcagag gtctactacg
     2401 acctgctcaa ggagagcgac aagcacgact accgcctcgt ctggatcaca cgttctccgc
     2461 gcttcttccc gatggagacc accaagctca cgctggagat gttctcgccg gactacatcg
     2521 accacttcta cagcctgccc gacggccgca aagatgccat cgttcgtgcg caggacagcc
     2581 tgtacaaggg cgtgaacacc agcctgatca accagatcta cgacctgctc gacgacaagc
     2641 gcaaggtggg cgaattgcgc acgcacctga tcaccaattg cgagctgcag gcgtgccgcc
     2701 acgacgccgc caccggcact tacgagatcg agttccagca ggtcgacagc ggtgcgcgct
     2761 atgcccatcg cacagaaggg ctggtgctcg ccacgggtta cgagcagaac atcccggcgt
     2821 tccttgatgg catccgccac cgtctgcgct gggatgccaa gggccgctac cagctctccc
     2881 gcaactacgc ggcagacgtc aatggcagcg aggtctacgt gcagaacgcg ggcctgcaca
     2941 cgcacggcgt gaccaatcag gacattggca tgagctgcta tcgcaactcc tacatcatcc
     3001 gagagctgac cggcgttgag cactacaaaa tcgagccgcg tgtggccatc caggattttg
     3061 cgattccggc cacaccggag ttcatcccgc tggcggctga gcggagcatc accgagcgcg
     3121 tgaaggagcc catcgaggaa gccgtatgac gctgcgcaac accatcatcc tgatgacggt
     3181 gtttgccgtc atcagcgatg cgatcctgat cccgttctat ccgcagttct tcgcgtcgcg
     3241 ctatgggctg gacagccccg tgcacgtagg ggcgtatgtg gccgccatct cgattaccgt
     3301 catgtgcacg ttgcccctct gggcacgtgt ggccaagcgc gtggagccgc tgtacctgct
     3361 ggtctacacg cagttcgcag ccggcacctt cagcctgctc agtgactggg cgccgaacgt
     3421 ggtgacgtac tgggtgctgt cgatgctgat gttcatgtgc aagagcagct acctgctgat
     3481 gtatccgtac atgatgcggc tcacgcccaa ggcgcagcac gcggccacgg tgggcaccct
     3541 ctcggtggtg gtgcactttg gcgccatctt cggggcggtg gtgggcggtc ttgtgctgca
     3601 gacatggggg ccgcgcgcca gcatcgtcgc catggcggcg ggcgatttct tccagatggg
     3661 tgtgtgcatg cacctgatcc gcagcggcaa gatcgtgcgc gtcaactcgg gcgagcatgc
     3721 cgaggcggct gccgctgaag ccgcacgcgt gccgcgcacc ggctggcgcg accgcctgcc
     3781 gatcctgcgc cttgcactgg tgatgctggt gttcgacttc agcgcgtacc tcatccgccc
     3841 gttcttctcg gtgtactggc agcaagtgtc ggggctcgac agcgagttcg tctcgggcat
     3901 ggcgtttgcc attccgggcg tggtcgccat cgtggcgctg cggttgcatg cccgtattcg
     3961 tgcgcgtggc ggtcagttgc cggatcacac cgtgggcaac ctgttgctgg gcatggtggg
     4021 cctgctgctg catgcggcgc ccaacccgat gttgatcgtg ctcgggcgcg tgctgtacgg
     4081 ctgggcgctg ttccagatca tcgtgaagct ggaggtgaac ctgttccggc tttctacgcc
     4141 gcagcgctat gcgcacgact acagcatcac caatttcttc cagaacatgg gggtgctgct
     4201 gtcttctttt gcggcagggg cgatcgtcaa tcgctacggg ctgcatctgc cgttcttgct
     4261 ggccgctggg ggctttgtgc tgacggcggt gctcgatcgg ctgatcttga atgtgcccag
     4321 cgccggccat gcagatgact cgggcagggc agaggcaccc gccaacctgg aggcgccggt
     4381 ccatgccaac tgatgcccac accatccacc gccgcgccga tgccgaaagc gcgccttaca
     4441 ccgatgcgga cggtttcacc ttccacctgc tgcgcattcc ggaagacatc ccgatgctgc
     4501 accgctggtt tcagccggag cgcgcctcgt tctggctgat gcgcgacaag acggaagccg
     4561 aggtcggtca ggtctatcag aacctgatgg actccggcca cgccaccgcg tatctcgtgt
     4621 ggcaaggcgg tcgcccggtc ttcctggccg agtgctacga ccccgcccac gatcgcatcc
     4681 gcacgttcta cgacgtacaa ccgggcgacc tcggcatgca catcttcatc gggccatcgg
     4741 atgtgcacat tgccggctac acgcgcgcgg tgttcttcgc actcatgcgt ttcatgttcg
     4801 atcgcctggg cgcggcacgc atcgtggtcg agcccgacgc caacaacaca cgcattcacg
     4861 ccatcaaccg cgcagccggt tttgtctacg accgcaacgt cgcctttacc gaaaagatcg
     4921 ccagtctcgc cttctgcact cggcaggatt ttgaacaagc taccagcgcc accgccattg
     4981 cttaaaccaa aggattcgcc atgaacgtca cgatccacaa tcagctctcg caacatccgg
     5041 cccaggcagc cgcccacctc acgccggaag tctgggcgca ggccaaccga ctgctgttgc
     5101 gcaaggcgat tgccgaatat gcgcacgaac gcatcctgga gcccgagtac ctgcatgcca
     5161 ccgctggcgg cttcgcgctg taccaggtgt tttcggatga cggcaaggtt tgctaccagt
     5221 tcgaagcgca gcaactcgcg ctgcgtcact ggttcatcca accggaatcg attcgccgtc
     5281 tggtcgaggg ggcccagcaa ccgctcgacg cgctgcaatt catcatcgaa tgccgtcagc
     5341 ggcttggtat tcgtgacgag ctgctgccca tctacctcga cgagatcagc agcacgctgt
     5401 tcggcagcgc gttcaagcgc atgaaggccg atgcacccag cagtgcacaa ctggccgagg
     5461 ccaccgactt ccaggccatc gaagttgcca tgatcgaagg gcaccccggt ttcgtcgcca
     5521 acaatgggcg cctgggcttc acctccgtcg actaccaggc ctatgcgccc gaggcgggtt
     5581 ccgatatccg cgtgatctgg ctggctgtac acaaggatca cgccacaccg tcaacgcttt
     5641 ccacgttgaa ctatgcgcaa atgctggccg aagaactcgg ccaggacacg gtggacgatt
     5701 tcacacgcca ggttgccgaa aagggcgtgg actctgccga ctatcacttc atgcccgcgc
     5761 acccgtggca gtggttcaac aagctgtcca tcgcgtttgc gggctatgtg gcgcagcgca
     5821 agatcatctg cctggactac agcgccgacc actacatcgc ccagcaatcc atccgcacat
     5881 tcttcaacac gagcgatcgc accaagcgct atgtgaagac gtcgctgtcg atcctgaaca
     5941 tgggctttat gcgcgggctc tcgccgtact acatgtcggg cacgccggcc atcaacgagt
     6001 tcatcaagga actggtctcg aaagatggct tcctgcgcga gaacggtttc accatcctgc
     6061 aggaagtggc ggccatcggt ttccgcaact tctactacga ggcggccatt ccggtggata
     6121 cgccgtacaa gaagcagttc tcggcgctgt ggcgcgagaa cccgctgccg cttctcaagc
     6181 cgggcgagcg cctgatgacg atggcggcgc tgctgcatgt cgacaaggac ggccatgcgc
     6241 tgatgcctga gttgatccgc cgctcgggcc tgccggcgct cacgtgggtg cgccagtacc
     6301 tgcaggtgta tctcacgccg ctgctgcatt gcttctacgc ttacgagctg actttcatgc
     6361 cgcacggcga gaacctcatc ctcgtgatgg acaaccacgt gcccgtgcgc gccatcatga
     6421 aagacattgc cgaggaatgc gccatcctcg acatcaaggc acgcgaatgg ctgcccgagc
     6481 gtgtgcagcg cctggcggtg gaggtaccgg acaacttcaa gctgctcggc atcttcatcg
     6541 acgtgttcga tggcgtcctg cgccacatca accacgtgct ggtggagaac gcttgctgca
     6601 ccgaagacca gttctggggc gccgtggccg attgcgtcta cgactatcag gacgcccatc
     6661 cggagcacgc cgccaaatac gcgcactacg acatgttcgt gcccgagttc ctgcactcgt
     6721 gcctgaaccg cttgcagctc ggcaacaacg tgcagatggt taacctggcc gacccggcat
     6781 cgagcctgaa gatcgcaggc aatctggtca accccatcgc caggttccgt cgtgcggcac
     6841 ctgccgtgca cgccgaagca acagacgcgg tggaagcggc ggcatgacag acggcatgcg
     6901 cgccttcgtt gaagacgcct cggggtcggg cttcgcgttg ccgcaagcct ggcgctcggc
     6961 gccgacaccg aacccggatc tcgcccacgc actgcggttg gcgcaacgtg tcattcccag
     7021 cctgcgcggc gagcagggtg gggtatcgcc agccaacgcg ctgcgcctgg gcgacgacgt
     7081 tgcgctgcag gcgctgtgcg atcactgggc gcaggcctat ccggaggcgg gcgcgcatta
     7141 cctcgccctg cgctgttggg ggctcgcgat ctggcagcca atctatctgt gtgtgattgc
     7201 cgtgcatctg gatggattgg cacccaggct ggcgggcctc gtgcagccgg tgaaggcggg
     7261 ttttcccagt ggcttccact tgcccgtgca tgcgccggtc ggcggcacat tcgttgggcg
     7321 gatggaggct gctgccgctg agttgcgggc gttctgcgat gccgtccgcc gggcgatcaa
     7381 gccaatggtt gccctgcatg agcgtgccgc agatcgcttg caagctgagt gcgtgctcgg
     7441 cgcgttgatg gcagtgcgac cacatacgtc attgtcggat gcagacatga ctgccatagg
     7501 ggaggcgtgg ctggtcgccc taggcattgc cggcggctgc ggcttctttg cctaccgtgc
     7561 gcgtgacggc acgcccgcac tcgcgcttga ccgcaaggtc tgctgccact atttccgccg
     7621 tcgcgacggc gagaaatgca gcacctgccc aaagctctcg ctcgacgcac gtatcgcccg
     7681 cttgctggcc gaagcgtcgt agcgcgcttt tcccccgata cctgatgggg cggatgccgg
     7741 ttcaacgtga acactgaacc gcccgccact ccgtgttgga gaccccgatg accgatgtcg
     7801 gacgcctggc ccatgtgatg ccagcgcata cccaattgcc cgtcgccgcg tacttcgacg
     7861 acgccttgtt cgcttgtgaa ctcgaaacca tcttcaagca atccgcctgc tatatcggca
     7921 atgaaaaagc cgtgcccgaa tccggcgatt ggcgccgcct cgcccaggaa gacggcggtc
     7981 gcgtactggt gcgcaatgcc ggcggcgtag aactgatgtc caacgtctgc cgccaccggc
     8041 aagcgctcat tcttggcggg gaggccggca acgtgactgg ccctgccaat gccaccggca
     8101 acctgggcgc ggcaggcggc aacatcgttt gtccgctgca ccgctggacg tacaccgatc
     8161 gcggtgaact gatcggcgcg ccgcagttca ccagcacgcc gtgcaagaac ctgcagcgct
     8221 tcaccctgcg caactgccac ggcttgttgt tcgaaggccc gcgcgacccg gcgcacgaca
     8281 tggcaccgtt gtttgctcgg cccgagttcg actttggtga ttacgtgctc gaccacgtag
     8341 aagttcacca atgcaactac aactggaaga ccttcatcga ggtctacctg gaggactacc
     8401 acgtcgcacc gttccacccc ggcctcggcc acttcgtcac gtgtgacaac ctcgaatggg
     8461 agtttgcaga ctggtacagc atgcagcgcg taggcatcca ccaggcgctt agccagccgg
     8521 gctcggatgt gtacggcgcc tggcatgacc ggctgctcga ctatcgctcc ggtacatcac
     8581 cggatttcgg cgcgatctgg gtgacgtact tcccgaccca catgatcgag ttgtatccgc
     8641 acgtgctggt gctctccacg ctgtacccga aagggccaca ggacaccgtc aacgtggtcg
     8701 agttctacta cccggaagag atcgccgcgt tcgagcgcga gttcgtggaa gcgcagcgcg
     8761 cggcctacat ggaaacctgc atcgaagatg acgagatcgg ggagcgcatg gacgctggcc
     8821 gccgcgcact gatggcacgc ggcgtgtcgg aaaccgggcc gtaccagtcg ccattggaag
     8881 acggcatgca gcatttccac gcgtggtatc gccgcatcat gggcacgctg ccggtcgccg
     8941 acgtatagcc gcgcgcacct gcgtcagatc aaggcgagcg gggagggcgg cggtacaatc
     9001 cgtcgcttct ctcccaggtg ttccatgcca cgcggcctcg ttctcgccac gccccagctc
     9061 acgtcggacg gcacgccgtt ctccgcgcaa tacgacgacg tttatcacag caccgaaggt
     9121 ggtctcgcac aggcgcaaca cgtcttcctg ggcggcaatg ctttgcccgg cgcatggcaa
     9181 ggcaagaacg cattcaccat tgtcgagacc ggcttcggcc aaggcctgaa tttcctggcg
     9241 acgtgggccg cgtggcgtga cgatccgcag cgttgcgcac ggctcgattt cgtttccatc
     9301 gaaaagcatc cgttcgaccg ggcgggcttg tctgtcgtgc acccgaaaga cggcgtgctt
     9361 gcgccgctgg gtgaggcgtt gcggcagtca tggcccgtac ccgtgcccgg tgtgcatcgc
     9421 ctcgtcttcg atgaggggcg cgtcacgctc acgctgctgt ttggcgatgc gatggagatg
     9481 ctgccgcaac tgtcctgcgc cgccgacgcg ttttatctgg atggcttctc gcccgccaag
     9541 aacccggacc tctggcagcc gcgcgtcttc aagcagcttg cgcgtgtcgc ccgcgctggc
     9601 gccacgctgg caacgtacac agcggcaggc tttgttcgac gcggcctgca ggaagccggc
     9661 ttcgaggcgc acaaggcacc gggcttcggc accaagcgcg atatgaccgt cgcgcagttt
     9721 ccaacgcact ggaagacgcg gcgcggcccg gtcgaagcgc ctgtttggtc tgagcgccac
     9781 gctatcgtcc tcggtgccgg gttagccggt tgttccgtcg cggaacgcct cgccgcgcgc
     9841 ggctggcgca tcacgctcat cgatgcgaac gaggggcccg ctcgcggcac atcagcgcac
     9901 cgcgccgcag ccatgcatcc gcatgtgtcc attgatgaca gcgtgctctc acgtctgtcg
     9961 cgcgctggca atctgctcgc atgtcggcag tgggacgcac tcgaccgcgc gggttttgcc
    10021 accggcttcc agcccaccgg tgtactgcag ctcgctgaac acgaggacga tgccgccgag
    10081 cagcagcgcg tcgtgcaggc gctcgggtac cccaccggct acatcgattg gctgagtgcc
    10141 agccaggctg ctgaacgtgt cggcgcgggc gtgccgcagg ggggctggtg gttcgggcag
    10201 gctggctggg tggcgccgcc cgatgtctgt cgagcgaacc tcgccgcagc cgccaacgca
    10261 actcatgcgc actggaacac ccgcgtcgaa tcgctgcgcg aagcaggcgg ccagtggcaa
    10321 gcgctcgacg cacacggtgg cgtgattgcc agcgcgccgg tcgtcatcct tgccaatagt
    10381 ttggatgcgg cccggctggc gccgctgtcg tctgcgtcgc tcaagccggt gcgcggccag
    10441 cttacggatg tgccgctcgt cagccttgag ccgagggcgg cttggccgag ggccgtggtg
    10501 tgcggtgatg gctacctgtt gccggcggaa cccgatgcgc aatccgtgcg gatcggctcg
    10561 tcattccagc cgggcgattc tgatctggcc gagcgcgccg gcgatcacgc cgccaacctg
    10621 aagcggctgg cgagcatgca gccgcagcaa tcgcaggcgc tggcgcggct ggacccggcg
    10681 cagttgcatg ggtacgtcgg ggtgcgttgc gtgtccgcca accgcttgcc gctgattggc
    10741 gcggtggtcg atgaggcggt ggccatggcg ccgggtttcc gcctgcgcgg gccgcatgcg
    10801 caactgcctc gcgtgccggg gctgtatgcc gcacttgcat acggctcgcg cggtctcaca
    10861 tggtcggtct tgggtgcgga attgctcgcc gcgcaaatcg acggcggtcc gttgccgctg
    10921 gaagttgacc ttgctgcggc gctggatccg gggcgctttg tcttgcgtgc attacagcat
    10981 ggacacgggc gcgggcaggg tgctgcaccc gctgaaactg aagcggcgga tacgctcgac
    11041 tgacccgctg tttgataggg tttccaagcg ttccgaccca aaaaatcagg gccggcgagc
    11101 gttccatgcc ataatatgcg ttttgcgttt gccagcccga acgcgcctgt tgcacccgtt
    11161 taagccgccg aagtgtcacc tgagcggccc tcgcgtcgca tccgcgcaag cccggcaaca
    11221 ccaagaactt tgaaccacgg ctgctgctgg cgctgcgccg ttcgacgcaa ctttcatctg
    11281 aatctggaat tacgaccatg tcgactatcg aaaacctcgg caagcttgat cgcaaagtga
    11341 ccctggctgt cccgaaggcc gaagtggagc aagagaagca aagccgtctg gcgcgtctgt
    11401 ccaagaccgt caagatgtcg ggcttccgtc cgggcaaggt cccgatgaag atggtcgaga
    11461 agcaatacgg ccaacaagtt gaattcgaag tccgctacga caaggctgcc cgtcagttct
    11521 tcgacatcac caatgagcaa ggcgtgaagg ttgccggcca accgcgcttc gagctgaaga
    11581 ccgaaggcgt ggccgacgac caagtcgcat tcgatgccac cttcgaggtg tatccggaag
    11641 tcaagctggg cgatctggcc ggcgcggaac tgacccgtac caagaccgag atcaccgacg
    11701 cggaaatcga caagaccctc gacattctgc gcaagcagcg tgtgcactac cacccgcgtg
    11761 gcgaggctgg tgagcacggt gacggcggcg ctgccgttgc acaaaacggc gaccgcgtga
    11821 cggtcgactt cgttggcacg atcgacggcg tggaatttgc cggcggcaag gctgaaggtt
    11881 tcagctt
//
