LOCUS       NZ_CP016022.1          25013 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP016022.1 Ralstonia insidiosa strain ATCC 49129 chromosome 1,
            complete sequence.
ACCESSION   NZ_CP016022
VERSION     NZ_CP016022.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:04:31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 163484
            Orig. end    :: 188497
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..25013
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[173484:178497]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15013
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..25013
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..25013
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             496..1275
                     /NRPS_PKS="Domain: ECH (16-251). E-value: 3.3e-48. Score:
                     155.9. Matches aSDomain: nrpspksdomains_ctg1_159_ECH.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 216.3; E-value:
                     6.4e-66)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_159"
                     /transl_table=11
                     /translation="VSTDPELLIEQRDQALWLTIQREDRRNAINGAVLEALMAALADAS
                     RNTAVRAVVLTGAGTRAFCAGADLQSGQSFRFDYSQPHQGLADLFRQARRCTVPLIARV
                     NGACMAGGMGLLAMCDMAVASRSAMFGLPEVKVGLFPAQVLAVLQHQLPRRLLNELCLT
                     GEPMSADRALAAGLINEVAEPEALDAAVDALLARLLDKSPSAIRRGLYTLKQVEHLSFE
                     QAMAFTESQIGLFALTEDAQEGQAAFREKRAPNWTGR"
     aSDomain        544..1248
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_159_ECH.1"
                     /evalue="3.30E-48"
                     /label="ctg1_159_ECH.1"
                     /locus_tag="ctg1_159"
                     /protein_end="251"
                     /protein_start="16"
                     /score="155.9"
                     /tool="antismash"
                     /translation="WLTIQREDRRNAINGAVLEALMAALADASRNTAVRAVVLTGAGTR
                     AFCAGADLQSGQSFRFDYSQPHQGLADLFRQARRCTVPLIARVNGACMAGGMGLLAMCD
                     MAVASRSAMFGLPEVKVGLFPAQVLAVLQHQLPRRLLNELCLTGEPMSADRALAAGLIN
                     EVAEPEALDAAVDALLARLLDKSPSAIRRGLYTLKQVEHLSFEQAMAFTESQIGLFALT
                     EDAQEGQAAFREK"
     PFAM_domain     544..1269
                     /aSDomain="ECH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00378.22"
                     /description="Enoyl-CoA hydratase/isomerase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_159_0001"
                     /evalue="9.30E-51"
                     /label="ctg1_159"
                     /locus_tag="ctg1_159"
                     /protein_end="258"
                     /protein_start="16"
                     /score="172.6"
                     /tool="antismash"
                     /translation="WLTIQREDRRNAINGAVLEALMAALADASRNTAVRAVVLTGAGTR
                     AFCAGADLQSGQSFRFDYSQPHQGLADLFRQARRCTVPLIARVNGACMAGGMGLLAMCD
                     MAVASRSAMFGLPEVKVGLFPAQVLAVLQHQLPRRLLNELCLTGEPMSADRALAAGLIN
                     EVAEPEALDAAVDALLARLLDKSPSAIRRGLYTLKQVEHLSFEQAMAFTESQIGLFALT
                     EDAQEGQAAFREKRAPNWTG"
     CDS             1277..3049
                     /locus_tag="ctg1_160"
                     /transl_table=11
                     /translation="MRKDTVSIGGASGFWGDSVTGPMQLVASGRIDFLVFDFLAELTMS
                     LLASARMKNAELGYATDFVSVAMRAVLKDALAQNIRIIANAGGVNPRGCAAALQALADE
                     LGVSVRIAVVEGDDVMPLLPALRDEGVRELQSGRPLPHKVVSANAYLGALPIKAALDAG
                     AQVVITGRCVDSAVTLGALMHSFGWAVDDYDRLAAGSLAGHILECGCQGAGGLHTDWEA
                     VPDWAHSGYPIVECGADGSFIVTKPEGTGGLVTPATVGEQLLYEIGDPARYVLPDVVCD
                     FTQVTMTQAGEHRVEVHGAHGIAPTPDYKVSATYADGYRATGQLTIVGVDADRKAHRTA
                     EAILERTRGLFHKLGLPDYSATHIETLGSAYLFGPHQPEVPRFESVMWLAVAHPNKQAL
                     ELFAREIAPAGTSWAPGTTGAGGRPSVVPAVKQYAFLIDKARVQPRVTLLGGESFDVAV
                     PTGGAPLEASTAATMTAALPTGPTREVPLIELAYARSGDKGDTSNIGVIARRPEDLPLL
                     RAQLTEDAVAAYLAHVARGRVTRYDLPGIHALNFVCERALGGGGMASLRNDPLGKGMAQ
                     VLLTMPVRVPVDHP"
     PFAM_domain     1298..2320
                     /aSDomain="AtuA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07287.13"
                     /description="Acyclic terpene utilisation family protein
                     AtuA"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_160_0002"
                     /evalue="3.70E-120"
                     /label="ctg1_160"
                     /locus_tag="ctg1_160"
                     /protein_end="348"
                     /protein_start="7"
                     /score="400.9"
                     /tool="antismash"
                     /translation="IGGASGFWGDSVTGPMQLVASGRIDFLVFDFLAELTMSLLASARM
                     KNAELGYATDFVSVAMRAVLKDALAQNIRIIANAGGVNPRGCAAALQALADELGVSVRI
                     AVVEGDDVMPLLPALRDEGVRELQSGRPLPHKVVSANAYLGALPIKAALDAGAQVVITG
                     RCVDSAVTLGALMHSFGWAVDDYDRLAAGSLAGHILECGCQGAGGLHTDWEAVPDWAHS
                     GYPIVECGADGSFIVTKPEGTGGLVTPATVGEQLLYEIGDPARYVLPDVVCDFTQVTMT
                     QAGEHRVEVHGAHGIAPTPDYKVSATYADGYRATGQLTIVGVDADRKAHRTAEAILERT
                     R"
     CDS             3064..4218
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 378.1; E-value:
                     8e-115)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_161"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.9e-31, bitscore:
                     106.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.1e-24, bitscore:
                     82.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6e-46, bitscore:
                     154.2, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTGLLTSVLFNAEHDTFRETVRRFVDKAVLPNIDAWEEAETFPR
                     ELYRKAAELGLLGIGFPEEYGGTPADLFLELAMIEELTRAASGGLLASLFSHTIGAPPI
                     VAGGSAELKSRVLPDILSGEKISALAITEPLGGSDVANLTTRAVRDGDHYIVNGSKIFI
                     TSGMRADYLTVAVRTGGPGAGGISVLLVDGDTPGLSRTPLKKMGWWCSDTAQLHFDNCR
                     VPVGNLLGAENRGFELVMRNFNHERLALAMQAYGLARTCLAEAVEWASQRETFGKRLVQ
                     HQVARQKLVAMATRIEATRALLEDLMRRMQAGESPVAQLCMLKNFATQSLQFCADTAVQ
                     LLGGMGFMRGTKSERIYREVKVYMIGGGAEEVLSDLAARQLGWV"
     PFAM_domain     3100..3435
                     /aSDomain="Acyl-CoA_dh_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02771.18"
                     /description="Acyl-CoA dehydrogenase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_161_0003"
                     /evalue="4.10E-31"
                     /label="ctg1_161"
                     /locus_tag="ctg1_161"
                     /protein_end="124"
                     /protein_start="12"
                     /score="108.0"
                     /tool="antismash"
                     /translation="AEHDTFRETVRRFVDKAVLPNIDAWEEAETFPRELYRKAAELGLL
                     GIGFPEEYGGTPADLFLELAMIEELTRAASGGLLASLFSHTIGAPPIVAGGSAELKSRV
                     LPDILSGE"
     PFAM_domain     3445..3726
                     /aSDomain="Acyl-CoA_dh_M"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02770.21"
                     /description="Acyl-CoA dehydrogenase, middle domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_161_0004"
                     /evalue="2.50E-23"
                     /label="ctg1_161"
                     /locus_tag="ctg1_161"
                     /protein_end="221"
                     /protein_start="127"
                     /score="82.2"
                     /tool="antismash"
                     /translation="ALAITEPLGGSDVANLTTRAVRDGDHYIVNGSKIFITSGMRADYL
                     TVAVRTGGPGAGGISVLLVDGDTPGLSRTPLKKMGWWCSDTAQLHFDNC"
     PFAM_domain     3760..4206
                     /aSDomain="Acyl-CoA_dh_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00441.26"
                     /description="Acyl-CoA dehydrogenase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_161_0005"
                     /evalue="3.10E-45"
                     /label="ctg1_161"
                     /locus_tag="ctg1_161"
                     /protein_end="381"
                     /protein_start="232"
                     /score="154.2"
                     /tool="antismash"
                     /translation="NRGFELVMRNFNHERLALAMQAYGLARTCLAEAVEWASQRETFGK
                     RLVQHQVARQKLVAMATRIEATRALLEDLMRRMQAGESPVAQLCMLKNFATQSLQFCAD
                     TAVQLLGGMGFMRGTKSERIYREVKVYMIGGGAEEVLSDLAARQL"
     CDS             4229..5116
                     /NRPS_PKS="Domain: PKS_KR (14-125). E-value: 5.7e-12.
                     Score: 37.7. Matches aSDomain:
                     nrpspksdomains_ctg1_162_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     215; E-value: 1.9e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_162"
                     /transl_table=11
                     /translation="MYRSVFRPGLFLGQVAVVTGGGSGIGRCTAHELASLGAAVALVGR
                     NADKLAAVRTEIVEAGGTAHAYVCNIRDEAAVQATVAQILGEHGRIDALVNNAGGQFPS
                     PLKDISVKGWEAVVQTNLTGGFLMARECLNQAMQQRGGAIVNIVADMWGGMPNMGHSGA
                     ARAGMINFTETAAFEWAQYGVRVNAVAPGYVASSGMDAYPPWMAETIRSMPRTVPAGRF
                     ATEAEVSSAIVYLLSEAAAFITGTTLRVDGGRPNVRPGTPMPAPRHGAAPFNGFHLAAT
                     PKVLQDKETDDAGA"
     aSDomain        4271..4603
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_162_PKS_KR.1"
                     /evalue="5.70E-12"
                     /label="ctg1_162_PKS_KR.1"
                     /locus_tag="ctg1_162"
                     /protein_end="125"
                     /protein_start="14"
                     /score="37.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAVVTGGGSGIGRCTAHELASLGAAVALVGRNADKLAAVRTEIVE
                     AGGTAHAYVCNIRDEAAVQATVAQILGEHGRIDALVNNAGGQFPSPLKDISVKGWEAVV
                     QTNLTGG"
     CDS_motif       4277..4366
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_162_0001"
                     /evalue="9.40E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_162"
                     /protein_end="46"
                     /protein_start="16"
                     /score="18.3"
                     /tool="antismash"
                     /translation="VVTGGGSGIGRCTAHELASLGAAVALVGRN"
     PFAM_domain     4295..4987
                     /aSDomain="adh_short_C2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13561.8"
                     /description="Enoyl-(Acyl carrier protein) reductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_162_0006"
                     /evalue="1.20E-53"
                     /label="ctg1_162"
                     /locus_tag="ctg1_162"
                     /protein_end="253"
                     /protein_start="22"
                     /score="182.2"
                     /tool="antismash"
                     /translation="SGIGRCTAHELASLGAAVALVGRNADKLAAVRTEIVEAGGTAHAY
                     VCNIRDEAAVQATVAQILGEHGRIDALVNNAGGQFPSPLKDISVKGWEAVVQTNLTGGF
                     LMARECLNQAMQQRGGAIVNIVADMWGGMPNMGHSGAARAGMINFTETAAFEWAQYGVR
                     VNAVAPGYVASSGMDAYPPWMAETIRSMPRTVPAGRFATEAEVSSAIVYLLSEAAAFIT
                     GTTLRVDGG"
     CDS             5103..6722
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059:acetyl-CoA carboxylase, carboxyl transferase,
                     (Score: 420.4; E-value: 1.9e-127)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_163"
                     /transl_table=11
                     /translation="MPVLESRIVPQSDAYQQNHAALTELVDQLRTLENRTRYKSEASRA
                     RFEQRGQLLPRDRLGRLLDAGAPFLELSSLAGFCLDHADPARSIPGGGFIAGIGWVSGV
                     RAMIIVDDAGIDAGAVQPMGIEKFQRAQAIALEQKLPFIHLVESAGANLLTYRVETFIH
                     GGSGFYWLARLSAAGIPVISVVHGSSTAGGAYMPGLSDYVVMVRDRARAFLAGPPLLKA
                     ATGEIATEEELGGAEMHATTSGLAEYLAEDDADALRIARELVAALDWNRDVPVADRPYA
                     PPRFDAEELLGIALTDHRKPLDMREVIARIADGSDFLEFKPDYGPATITGHAAICGMHV
                     GIITNNGPLDPAGATKVVHFIQACCQSDTPLLYLQNTTGFIVGKQSEQAGMIKHGSKMI
                     QAMANATVPRITVHCGASFGAGNYGMSGRGFFPDFCFSWPNAKTAVMGAEQAAGTMATV
                     MAASMQRKTQTIDHDAIEAMRAKVIDTFERQSGAFTVSGRLLDDGVIDPRDTRKVLACV
                     LAVCDEARRRTLHPIQFGVARP"
     PFAM_domain     5247..6680
                     /aSDomain="Carboxyl_trans"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01039.24"
                     /description="Carboxyl transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_163_0007"
                     /evalue="4.20E-112"
                     /label="ctg1_163"
                     /locus_tag="ctg1_163"
                     /protein_end="526"
                     /protein_start="48"
                     /score="375.4"
                     /tool="antismash"
                     /translation="QRGQLLPRDRLGRLLDAGAPFLELSSLAGFCLDHADPARSIPGGG
                     FIAGIGWVSGVRAMIIVDDAGIDAGAVQPMGIEKFQRAQAIALEQKLPFIHLVESAGAN
                     LLTYRVETFIHGGSGFYWLARLSAAGIPVISVVHGSSTAGGAYMPGLSDYVVMVRDRAR
                     AFLAGPPLLKAATGEIATEEELGGAEMHATTSGLAEYLAEDDADALRIARELVAALDWN
                     RDVPVADRPYAPPRFDAEELLGIALTDHRKPLDMREVIARIADGSDFLEFKPDYGPATI
                     TGHAAICGMHVGIITNNGPLDPAGATKVVHFIQACCQSDTPLLYLQNTTGFIVGKQSEQ
                     AGMIKHGSKMIQAMANATVPRITVHCGASFGAGNYGMSGRGFFPDFCFSWPNAKTAVMG
                     AEQAAGTMATVMAASMQRKTQTIDHDAIEAMRAKVIDTFERQSGAFTVSGRLLDDGVID
                     PRDTRKVLACVLAVCDEARR"
     CDS             6776..7933
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 346.1; E-value:
                     4.1e-105)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_164"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-28, bitscore:
                     97.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.7e-27, bitscore:
                     91.3, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.5e-40, bitscore:
                     136.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHFTHEHQELQRNLKRFIDSDINPYVEEWEAAEMFPAKALFKKMG
                     DLGFLGIAKPTEFGGLGLDYSYAMAMAETLGHIHCGGVPMAIGVQTDMATPALARFGSD
                     ELRAQFLAPAISGDAVACVGVSEPSAGSDVAGIKTTARKDGDDYIINGSKMWITNSLQA
                     DWMCLLANTSDDPAHRNKSLIIVPMNTKGVSVGKKIRKIGMNSSDTGLIYFDDVRVPQR
                     YRIGEEGKGFTYQMLQFQEERMWAAASSLQTMMMCIDSTIEYGRERKLFGASLLDNQWV
                     HFKLAELKTEVEALRALTYRACDLYINGQDVTELASMAKLKAGRLSRIVPDACLQFWGG
                     MGFTWDNPVSRYYRDGRLGSIGGGADEVMLGIICKYMNTLPGKKG"
     PFAM_domain     6785..7129
                     /aSDomain="Acyl-CoA_dh_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02771.18"
                     /description="Acyl-CoA dehydrogenase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_164_0008"
                     /evalue="6.40E-28"
                     /label="ctg1_164"
                     /locus_tag="ctg1_164"
                     /protein_end="118"
                     /protein_start="3"
                     /score="97.8"
                     /tool="antismash"
                     /translation="THEHQELQRNLKRFIDSDINPYVEEWEAAEMFPAKALFKKMGDLG
                     FLGIAKPTEFGGLGLDYSYAMAMAETLGHIHCGGVPMAIGVQTDMATPALARFGSDELR
                     AQFLAPAISGD"
     PFAM_domain     7139..7426
                     /aSDomain="Acyl-CoA_dh_M"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02770.21"
                     /description="Acyl-CoA dehydrogenase, middle domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_164_0009"
                     /evalue="3.20E-26"
                     /label="ctg1_164"
                     /locus_tag="ctg1_164"
                     /protein_end="217"
                     /protein_start="121"
                     /score="91.5"
                     /tool="antismash"
                     /translation="CVGVSEPSAGSDVAGIKTTARKDGDDYIINGSKMWITNSLQADWM
                     CLLANTSDDPAHRNKSLIIVPMNTKGVSVGKKIRKIGMNSSDTGLIYFDDV"
     PFAM_domain     7460..7900
                     /aSDomain="Acyl-CoA_dh_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00441.26"
                     /description="Acyl-CoA dehydrogenase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_164_0010"
                     /evalue="7.90E-40"
                     /label="ctg1_164"
                     /locus_tag="ctg1_164"
                     /protein_end="375"
                     /protein_start="228"
                     /score="136.6"
                     /tool="antismash"
                     /translation="GKGFTYQMLQFQEERMWAAASSLQTMMMCIDSTIEYGRERKLFGA
                     SLLDNQWVHFKLAELKTEVEALRALTYRACDLYINGQDVTELASMAKLKAGRLSRIVPD
                     ACLQFWGGMGFTWDNPVSRYYRDGRLGSIGGGADEVMLGIICK"
     CDS             7937..9931
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     697.3; E-value: 3.9e-211)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_165"
                     /sec_met_domain="ATP-grasp (E-value: 3.2e-09, bitscore:
                     34.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTPHAAFRTVLIANRGEIALRILRTARRLGMRTVAVYSDADRDA
                     PHCRAADLALPIGASQPQASYLNIAALLEAARKSGAQAVHPGYGFLAESDAFANACAEA
                     GLVFIGPPAEAILAMGNKAGAKRLMEAAGVPCVPGYQGEDQSDARMQQEAERIGYPVMI
                     KAAAGGGGRGMRRVDRAEDFAAALQSARSEAENAFASGELILEKAIVEPRHIEIQVFAD
                     KHGNVVHLGERDCSVQRRHQKVIEESPSPAVSPELRARMGAVSVAAARAIGYVGAGTLE
                     FLLAPDGAFYFMEMNTRLQVEHAVTEAVVGVDLVEWQLRVALGEPLPLSQDAIDARRAQ
                     GGHAIEVRLCAEDPQQNFLPQSGTVARWRAPREVRTDHALADGLVVSPYYDSMLAKIVA
                     HGMDRADACRRLVHALDDCLLLGLPTNRAFLRQCVAHPAFLAGDVSTAFIDRHFPVAMR
                     QAAVPDAAVCQAAAVLLTHSRKDAVRRYPTELQGWASSRTYPTLCRFTLDGEAIEMRVR
                     ALAVQRWEVSWDGGTAQAEIVSEADGRLTLALGDRLYPIEYAITGTAYHFVLDGREHTA
                     IDTTYAKAERNGAQAGSGRISAPMNGRVVAVHVTEGEAVSAGQLLLVVEAMKMEHSIAA
                     PLAGEVKGLFTQVGAQVAPGGLLMEIAAA"
     PFAM_domain     7958..8284
                     /aSDomain="Biotin_carb_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00289.24"
                     /description="Biotin carboxylase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_165_0011"
                     /evalue="3.80E-42"
                     /label="ctg1_165"
                     /locus_tag="ctg1_165"
                     /protein_end="116"
                     /protein_start="7"
                     /score="143.4"
                     /tool="antismash"
                     /translation="FRTVLIANRGEIALRILRTARRLGMRTVAVYSDADRDAPHCRAAD
                     LALPIGASQPQASYLNIAALLEAARKSGAQAVHPGYGFLAESDAFANACAEAGLVFIGP
                     PAEAI"
     PFAM_domain     8300..8920
                     /aSDomain="CPSase_L_D2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02786.19"
                     /description="Carbamoyl-phosphate synthase L chain, ATP
                     binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_165_0012"
                     /evalue="2.30E-73"
                     /label="ctg1_165"
                     /locus_tag="ctg1_165"
                     /protein_end="328"
                     /protein_start="121"
                     /score="246.3"
                     /tool="antismash"
                     /translation="KAGAKRLMEAAGVPCVPGYQGEDQSDARMQQEAERIGYPVMIKAA
                     AGGGGRGMRRVDRAEDFAAALQSARSEAENAFASGELILEKAIVEPRHIEIQVFADKHG
                     NVVHLGERDCSVQRRHQKVIEESPSPAVSPELRARMGAVSVAAARAIGYVGAGTLEFLL
                     APDGAFYFMEMNTRLQVEHAVTEAVVGVDLVEWQLRVALGEPLP"
     PFAM_domain     8972..9286
                     /aSDomain="Biotin_carb_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02785.21"
                     /description="Biotin carboxylase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_165_0013"
                     /evalue="9.10E-34"
                     /label="ctg1_165"
                     /locus_tag="ctg1_165"
                     /protein_end="450"
                     /protein_start="345"
                     /score="115.9"
                     /tool="antismash"
                     /translation="EVRLCAEDPQQNFLPQSGTVARWRAPREVRTDHALADGLVVSPYY
                     DSMLAKIVAHGMDRADACRRLVHALDDCLLLGLPTNRAFLRQCVAHPAFLAGDVSTAFI
                     D"
     PFAM_domain     9722..9919
                     /aSDomain="Biotin_lipoyl"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00364.24"
                     /description="Biotin-requiring enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_165_0014"
                     /evalue="1.40E-15"
                     /label="ctg1_165"
                     /locus_tag="ctg1_165"
                     /protein_end="661"
                     /protein_start="595"
                     /score="56.9"
                     /tool="antismash"
                     /translation="ISAPMNGRVVAVHVTEGEAVSAGQLLLVVEAMKMEHSIAAPLAGE
                     VKGLFTQVGAQVAPGGLLMEI"
     CDS             10001..11587
                     /NRPS_PKS="Domain: AMP-binding (24-425). E-value: 7.3e-100.
                     Score: 326.2. Matches aSDomain:
                     nrpspksdomains_ctg1_166_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     391.1; E-value: 1.1e-118)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_166"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-108, bitscore:
                     359.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEATPDTTLEANLLNRVTLGDTLHRSARKFGAKVALVDGPRRMT
                     HAQLNADSNRYAHHLLASGLKPGDKVAMLCGNSAQFLVAAYGIIKAGLVWVPINAMLGP
                     DDVRYILEHAEVRHVVIDAALYPVLRETLAALGLPGHQCFGEPAAGGPETVEQALQGHA
                     DTLPAVMIDDRDLALIMYTSGTTGRPKGAMHSHRSVHAALMSNIAGLNLNEKDVFSCIL
                     PMFHCAQFSTAASAMTVGATLVIQRGFDPTALLDAITNERITQLFGLPLMYAALLHHPL
                     RAQRDLSSLRLCLYAMAPMAKPLLERLIAEVCPNFALGSGQTEIFPMTMYFAPDQQLQR
                     TGNYWGQPCMVNEAAVMDDEGNLLGPNQLGEIVHRGPNVMLGYYKDPQATANARRFGWH
                     HTGDLGMWDADGQLQFKDRIKDMIKTGGENVPSLKVEEVLLRHPAVANAAVVGLPHAHW
                     VVAVAAFVCLKPDAQADATALQAHCREHLGSFEVPKHISVVDKLPMTATGKIQKHVLRS
                     ANQTLFESDAR"
     aSDomain        10073..11275
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_166_AMP-binding.1"
                     /evalue="7.30E-100"
                     /label="ctg1_166_AMP-binding.1"
                     /locus_tag="ctg1_166"
                     /protein_end="425"
                     /protein_start="24"
                     /score="326.2"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="HRSARKFGAKVALVDGPRRMTHAQLNADSNRYAHHLLASGLKPGD
                     KVAMLCGNSAQFLVAAYGIIKAGLVWVPINAMLGPDDVRYILEHAEVRHVVIDAALYPV
                     LRETLAALGLPGHQCFGEPAAGGPETVEQALQGHADTLPAVMIDDRDLALIMYTSGTTG
                     RPKGAMHSHRSVHAALMSNIAGLNLNEKDVFSCILPMFHCAQFSTAASAMTVGATLVIQ
                     RGFDPTALLDAITNERITQLFGLPLMYAALLHHPLRAQRDLSSLRLCLYAMAPMAKPLL
                     ERLIAEVCPNFALGSGQTEIFPMTMYFAPDQQLQRTGNYWGQPCMVNEAAVMDDEGNLL
                     GPNQLGEIVHRGPNVMLGYYKDPQATANARRFGWHHTGDLGMWDADGQLQFKDRIKDMI
                     KT"
     PFAM_domain     10073..11275
                     /aSDomain="AMP-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00501.30"
                     /description="AMP-binding enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_166_0015"
                     /evalue="6.90E-102"
                     /label="ctg1_166"
                     /locus_tag="ctg1_166"
                     /protein_end="425"
                     /protein_start="24"
                     /score="341.3"
                     /tool="antismash"
                     /translation="HRSARKFGAKVALVDGPRRMTHAQLNADSNRYAHHLLASGLKPGD
                     KVAMLCGNSAQFLVAAYGIIKAGLVWVPINAMLGPDDVRYILEHAEVRHVVIDAALYPV
                     LRETLAALGLPGHQCFGEPAAGGPETVEQALQGHADTLPAVMIDDRDLALIMYTSGTTG
                     RPKGAMHSHRSVHAALMSNIAGLNLNEKDVFSCILPMFHCAQFSTAASAMTVGATLVIQ
                     RGFDPTALLDAITNERITQLFGLPLMYAALLHHPLRAQRDLSSLRLCLYAMAPMAKPLL
                     ERLIAEVCPNFALGSGQTEIFPMTMYFAPDQQLQRTGNYWGQPCMVNEAAVMDDEGNLL
                     GPNQLGEIVHRGPNVMLGYYKDPQATANARRFGWHHTGDLGMWDADGQLQFKDRIKDMI
                     KT"
     CDS_motif       10529..10588
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_166_0001"
                     /evalue="2.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg1_166"
                     /protein_end="196"
                     /protein_start="176"
                     /score="26.1"
                     /tool="antismash"
                     /translation="ALIMYTSGTTGRPKGAMHSH"
     CDS_motif       11108..11173
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_166_0002"
                     /evalue="3.20E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg1_166"
                     /protein_end="391"
                     /protein_start="369"
                     /score="16.3"
                     /tool="antismash"
                     /translation="GEIVHRGPNVMLGYYKDPQATA"
     PFAM_domain     11300..11527
                     /aSDomain="AMP-binding_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13193.8"
                     /description="AMP-binding enzyme C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_166_0016"
                     /evalue="4.50E-21"
                     /label="ctg1_166"
                     /locus_tag="ctg1_166"
                     /protein_end="509"
                     /protein_start="433"
                     /score="75.7"
                     /tool="antismash"
                     /translation="KVEEVLLRHPAVANAAVVGLPHAHWVVAVAAFVCLKPDAQADATA
                     LQAHCREHLGSFEVPKHISVVDKLPMTATGK"
     CDS             complement(11594..12259)
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 105.6; E-value: 7.3e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_167"
                     /transl_table=11
                     /translation="MSKPAPPNLTESTTDADAPRRKRGRPAQDANEGLRRALIEQSARL
                     FREKGYGNTTVRDIAAATGVHAGSWFYHFKTKQEILQAVIEHGLTVALADIEAIDIDGQ
                     PPREAMRQLVRAHLYTILAPNQDFIPVMLYEWRSLDAHAQERIIALKDRYEGIWNHVID
                     RLRASGDWAQPTPVDRLLMFGALNWTAQWYQAGAGISIDALADQAVLFILRTPPQPAA"
     PFAM_domain     complement(11618..11950)
                     /aSDomain="TetR_C_24"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF17932.3"
                     /description="Tetracyclin repressor-like, C-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_167_0018"
                     /evalue="3.30E-20"
                     /label="ctg1_167"
                     /locus_tag="ctg1_167"
                     /protein_end="214"
                     /protein_start="103"
                     /score="72.5"
                     /tool="antismash"
                     /translation="QPPREAMRQLVRAHLYTILAPNQDFIPVMLYEWRSLDAHAQERII
                     ALKDRYEGIWNHVIDRLRASGDWAQPTPVDRLLMFGALNWTAQWYQAGAGISIDALADQ
                     AVLFILR"
     PFAM_domain     complement(12008..12148)
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_167_0017"
                     /evalue="2.80E-14"
                     /label="ctg1_167"
                     /locus_tag="ctg1_167"
                     /protein_end="84"
                     /protein_start="37"
                     /score="52.7"
                     /tool="antismash"
                     /translation="LIEQSARLFREKGYGNTTVRDIAAATGVHAGSWFYHFKTKQEILQ
                     AV"
     CDS             complement(12306..13271)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     75.4; E-value: 7.6e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_168"
                     /transl_table=11
                     /translation="MAEHDIITLPNSMRVFERGWLSSNNILFFDDEVGDGEHGGCALVD
                     SGYLTHAPQTVALVQHALQGKPLRRLLNTHLHSDHCGGNAALQALYSCHTRVPAAQVDD
                     VRRWDTDALSYGPTGQECARFTLPDSDADAGLADGMTVHLGGFDWQVISAPGHDPNAVI
                     LYSPESRVLLSADALWERGFGIIFPELEGESGFAEQQAILERIAQLDVRVVIPGHGRPF
                     TEVGAAIDASLGRLAYLRADPERNALHAIRVLVKFKLLEQQALSHEALFAWFTQTTLMT
                     RLQARFFANQSMTDLLDAAIGALVKAGAATVEQGQIRNRD"
     PFAM_domain     complement(12618..13160)
                     /aSDomain="Lactamase_B"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00753.29"
                     /description="Metallo-beta-lactamase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_168_0019"
                     /evalue="1.50E-20"
                     /label="ctg1_168"
                     /locus_tag="ctg1_168"
                     /protein_end="218"
                     /protein_start="37"
                     /score="74.1"
                     /tool="antismash"
                     /translation="HGGCALVDSGYLTHAPQTVALVQHALQGKPLRRLLNTHLHSDHCG
                     GNAALQALYSCHTRVPAAQVDDVRRWDTDALSYGPTGQECARFTLPDSDADAGLADGMT
                     VHLGGFDWQVISAPGHDPNAVILYSPESRVLLSADALWERGFGIIFPELEGESGFAEQQ
                     AILERIAQLDVRVVIPGH"
     CDS             complement(13284..13550)
                     /locus_tag="ctg1_169"
                     /transl_table=11
                     /translation="MDSCTRAQLKLSLGKLRNSRAQAERAQPVTSPCISVCKMDDARGL
                     CLGCMRTIDEIAAWSTMSDAARLAVWQTLPERACAWLNDTPRA"
     PFAM_domain     complement(13320..13460)
                     /aSDomain="DUF1289"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06945.15"
                     /description="Protein of unknown function (DUF1289)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_169_0020"
                     /evalue="7.00E-23"
                     /label="ctg1_169"
                     /locus_tag="ctg1_169"
                     /protein_end="77"
                     /protein_start="30"
                     /score="80.3"
                     /tool="antismash"
                     /translation="SPCISVCKMDDARGLCLGCMRTIDEIAAWSTMSDAARLAVWQTLP
                     ER"
     CDS             complement(13561..14061)
                     /locus_tag="ctg1_170"
                     /transl_table=11
                     /translation="MTAPDTNAPLPESAQRVADHLRTLGYEKAIVMLPATGKTSAEAAA
                     GLGCSVAEIAKSIIFRRAKDDVPVLVIASGTNRVDEAKVSAHVGALAKADAKFVREKTG
                     YAIGGVCPVGHAVKPVMLLDQDLFQYASVWAAAGHPHAVFNLTPAELEAMTGAPVADIA
                     QRD"
     PFAM_domain     complement(13606..13953)
                     /aSDomain="tRNA_edit"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04073.17"
                     /description="Aminoacyl-tRNA editing domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_170_0021"
                     /evalue="8.10E-23"
                     /label="ctg1_170"
                     /locus_tag="ctg1_170"
                     /protein_end="152"
                     /protein_start="36"
                     /score="80.9"
                     /tool="antismash"
                     /translation="GKTSAEAAAGLGCSVAEIAKSIIFRRAKDDVPVLVIASGTNRVDE
                     AKVSAHVGALAKADAKFVREKTGYAIGGVCPVGHAVKPVMLLDQDLFQYASVWAAAGHP
                     HAVFNLTPAELE"
     CDS             complement(14084..15013)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 211.8;
                     E-value: 3.1e-64)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_171"
                     /sec_met_domain="HMGL-like (E-value: 3.7e-53, bitscore:
                     178.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYPQFVKVVEVGPRDGLQNEKAPVSTDTKVELVNRLSDAGFVNV
                     EAASFVSPKWVPAMADGADVMARIQRRPGTLYSVLTPNMKGFEGAAAAGADEIVIFSAA
                     SEAFAQKNINCSIAESIERFVPVAKAAKDAGIRVRGSISCSLGCPYQGEVPVSSVVDVI
                     KRMADLGCDEIDIADTIGVGTAGRVKTVMEAAAATFPIDRLSGHFHDTYGQALANILAS
                     LEVGIHIFHASVAGLGGCPYAKGATGNVATEDVLYLLHGLGIRTGIDLDKVVLAGDFIS
                     QAIGRPTASRAGRALLLKLQDQIAQACI"
     PFAM_domain     complement(14180..14995)
                     /aSDomain="HMGL-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00682.21"
                     /description="HMGL-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_171_0022"
                     /evalue="3.30E-53"
                     /label="ctg1_171"
                     /locus_tag="ctg1_171"
                     /protein_end="278"
                     /protein_start="6"
                     /score="181.0"
                     /tool="antismash"
                     /translation="VKVVEVGPRDGLQNEKAPVSTDTKVELVNRLSDAGFVNVEAASFV
                     SPKWVPAMADGADVMARIQRRPGTLYSVLTPNMKGFEGAAAAGADEIVIFSAASEAFAQ
                     KNINCSIAESIERFVPVAKAAKDAGIRVRGSISCSLGCPYQGEVPVSSVVDVIKRMADL
                     GCDEIDIADTIGVGTAGRVKTVMEAAAATFPIDRLSGHFHDTYGQALANILASLEVGIH
                     IFHASVAGLGGCPYAKGATGNVATEDVLYLLHGLGIRTGIDLDKVVLAGD"
     CDS             complement(15015..15956)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 150.9; E-value: 5.6e-46)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_172"
                     /transl_table=11
                     /translation="MHIQIYTPDGKPQPWLDGFAQALPEARLSVWEHGAAQDADYAVVW
                     QPPADMLRGRTDLRAVFNLGAGVDAILGLRAQSPDAIPEGLPIVRLDDAGMAAQMGEYV
                     THAVLRFFRRLDEYERQQQAKMWRFLKPFNRDEFVVGVLGLGVLGTHIAKTLAGFGFPV
                     RGWSRSTKAIDGIDCRAGADALPGFLSGTRVLVNVLPLTADTENVIDAKLLAQLAPGAF
                     LVNVARGKHVVEDDLLAAVRSGHIAGAALDVFRKEPLPVDHPFWTEPRIHITPHISALT
                     LREVSIAQIARKIRALEAGEPIVGIVDLQRGY"
     PFAM_domain     complement(15123..15638)
                     /aSDomain="2-Hacid_dh_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02826.21"
                     /description="D-isomer specific 2-hydroxyacid
                     dehydrogenase, NAD binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_172_0023"
                     /evalue="6.00E-46"
                     /label="ctg1_172"
                     /locus_tag="ctg1_172"
                     /protein_end="278"
                     /protein_start="106"
                     /score="156.1"
                     /tool="antismash"
                     /translation="AVLRFFRRLDEYERQQQAKMWRFLKPFNRDEFVVGVLGLGVLGTH
                     IAKTLAGFGFPVRGWSRSTKAIDGIDCRAGADALPGFLSGTRVLVNVLPLTADTENVID
                     AKLLAQLAPGAFLVNVARGKHVVEDDLLAAVRSGHIAGAALDVFRKEPLPVDHPFWTEP
                     RIHITPHIS"
     CDS             complement(16046..16441)
                     /locus_tag="ctg1_173"
                     /transl_table=11
                     /translation="MARKPRLSVKLTENFEHNLEAIEAFWIEREFPEGYDRLLDELTET
                     VVPNLEQFPTMGPPLLSRTATSVEALTKQGQLKRQLARVADGELREYVLQEYLVLYAHL
                     GETIYLLSIRHHRQLSFDFAHLWPGQH"
     PFAM_domain     complement(16088..16417)
                     /aSDomain="ParE_toxin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05016.17"
                     /description="ParE toxin of type II toxin-antitoxin system,
                     parDE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_173_0024"
                     /evalue="3.70E-06"
                     /label="ctg1_173"
                     /locus_tag="ctg1_173"
                     /protein_end="118"
                     /protein_start="8"
                     /score="27.6"
                     /tool="antismash"
                     /translation="VKLTENFEHNLEAIEAFWIEREFPEGYDRLLDELTETVVPNLEQF
                     PTMGPPLLSRTATSVEALTKQGQLKRQLARVADGELREYVLQEYLVLYAHLGETIYLLS
                     IRHHRQ"
     CDS             complement(16449..16745)
                     /locus_tag="ctg1_174"
                     /transl_table=11
                     /translation="MAFSARDVIPLSQARANLSELAEQVKAGAEKIVTKNGESYIALID
                     AQRLDYYHQLERARIHLLLLDDAAKGLADVEAGRVKDARQALGALKRRRGSKA"
     PFAM_domain     complement(16521..16727)
                     /aSDomain="PhdYeFM_antitox"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02604.21"
                     /description="Antitoxin Phd_YefM, type II toxin-antitoxin
                     system"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_174_0025"
                     /evalue="2.60E-14"
                     /label="ctg1_174"
                     /locus_tag="ctg1_174"
                     /protein_end="75"
                     /protein_start="6"
                     /score="52.9"
                     /tool="antismash"
                     /translation="DVIPLSQARANLSELAEQVKAGAEKIVTKNGESYIALIDAQRLDY
                     YHQLERARIHLLLLDDAAKGLADV"
     aSDomain        complement(16602..16724)
                     /aSDomain="TIGR01552"
                     /aSTool="tigrfam"
                     /description="phd_fam: prevent-host-death family protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_174_0001"
                     /evalue="8.80E-07"
                     /identifier="TIGR01552"
                     /label="ctg1_174"
                     /locus_tag="ctg1_174"
                     /protein_end="48"
                     /protein_start="7"
                     /score="26.2"
                     /tool="antismash"
                     /translation="VIPLSQARANLSELAEQVKAGAEKIVTKNGESYIALIDAQR"
     CDS             complement(16838..18862)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     734.4; E-value: 2.2e-222)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_175"
                     /sec_met_domain="ATP-grasp (E-value: 4.7e-08, bitscore:
                     30.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITKLLIANRGEIACRVAATCRKLGIRTVAVYSDADANARHVAAC
                     DEAIHIGEPAARDSYLRADRILEAALATGAQAVHPGYGFLSENEAFAKACADAGIIFVG
                     PPASAIEAMGSKSAAKALMEKAGVPLVPGYHGDNQDAAFLRTQADRIGYPVLIKASAGG
                     GGKGMRVVESGDAFEASLASVKREASSSFGDDRVLIEKYLTRPRHIEIQVFADGFGDAV
                     YLFERDCSVQRRHQKVLEEAPAPGMTLDRRRAMGEAAVAAARAVGYVGAGTVEFIVDED
                     GTFYFMEMNTRLQVEHPVTEMITGEDLVEWQLRVASGEPLPRSQDELHIHGHALEARIY
                     AENPDRDFLPSIGTLKVLRTPAAVEFTVGAQANGEPAAVRIDAGVREGDAISPYYDPMI
                     AKLIVWGRDREEALARMLQALGEFHLVGLSSNVAFLRRLVASKPFATADLDTGLIARNH
                     DTLFPAALDVPQDAIALAVAALLAREARSLRTDTRDPHSPWARGSGWRLNGAAERALRF
                     THGEQAVDATLIYGRDGSRLKTNGDEAPFTTQRHGETFTVALGSHKATGQVHVDGDAFH
                     VFTGGAHWTLERHDPLAHAGETDDEGGKLTAPMPGKVIAVLATPGQTVTKGAPLVVMEA
                     MKMEHTLTAPADGVVESVLYGVGDQVTEGVQLLAFKPAE"
     PFAM_domain     complement(16862..17053)
                     /aSDomain="Biotin_lipoyl"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00364.24"
                     /description="Biotin-requiring enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_175_0029"
                     /evalue="1.90E-16"
                     /label="ctg1_175"
                     /locus_tag="ctg1_175"
                     /protein_end="667"
                     /protein_start="603"
                     /score="59.7"
                     /tool="antismash"
                     /translation="KLTAPMPGKVIAVLATPGQTVTKGAPLVVMEAMKMEHTLTAPADG
                     VVESVLYGVGDQVTEGVQL"
     PFAM_domain     complement(17498..17857)
                     /aSDomain="Biotin_carb_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02785.21"
                     /description="Biotin carboxylase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_175_0028"
                     /evalue="6.60E-34"
                     /label="ctg1_175"
                     /locus_tag="ctg1_175"
                     /protein_end="455"
                     /protein_start="335"
                     /score="116.3"
                     /tool="antismash"
                     /translation="EARIYAENPDRDFLPSIGTLKVLRTPAAVEFTVGAQANGEPAAVR
                     IDAGVREGDAISPYYDPMIAKLIVWGRDREEALARMLQALGEFHLVGLSSNVAFLRRLV
                     ASKPFATADLDTGLIA"
     PFAM_domain     complement(17897..18517)
                     /aSDomain="CPSase_L_D2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02786.19"
                     /description="Carbamoyl-phosphate synthase L chain, ATP
                     binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_175_0027"
                     /evalue="5.60E-76"
                     /label="ctg1_175"
                     /locus_tag="ctg1_175"
                     /protein_end="322"
                     /protein_start="115"
                     /score="254.8"
                     /tool="antismash"
                     /translation="KSAAKALMEKAGVPLVPGYHGDNQDAAFLRTQADRIGYPVLIKAS
                     AGGGGKGMRVVESGDAFEASLASVKREASSSFGDDRVLIEKYLTRPRHIEIQVFADGFG
                     DAVYLFERDCSVQRRHQKVLEEAPAPGMTLDRRRAMGEAAVAAARAVGYVGAGTVEFIV
                     DEDGTFYFMEMNTRLQVEHPVTEMITGEDLVEWQLRVASGEPLP"
     PFAM_domain     complement(18533..18862)
                     /aSDomain="Biotin_carb_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00289.24"
                     /description="Biotin carboxylase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_175_0026"
                     /evalue="1.60E-43"
                     /label="ctg1_175"
                     /locus_tag="ctg1_175"
                     /protein_end="110"
                     /protein_start="0"
                     /score="147.9"
                     /tool="antismash"
                     /translation="MITKLLIANRGEIACRVAATCRKLGIRTVAVYSDADANARHVAAC
                     DEAIHIGEPAARDSYLRADRILEAALATGAQAVHPGYGFLSENEAFAKACADAGIIFVG
                     PPASAI"
     CDS             complement(19562..20644)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF06968"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_176"
                     /sec_met_domain="PF06968 (E-value: 3e-21, bitscore: 73.1,
                     seeds: 824, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.5e-18, bitscore: 64.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPTPLNFVPNAAKVPVTPGQAPDARWSREAIEALFALPFNDLLF
                     QAQQVHRANFDANAVQLSTLLSIKTGGCPEDCSYCPQSARYDTGVEAEKLMPIDEVLEA
                     ASRAKQNGASRFCMGAAWRNPKPHQLDAVADMVRGVKAMGLETCVTLGMLKQEQAAQLK
                     DAGLDYYNHNLDTAPEFYGEIITTRTYQDRLDTLEHVRDAGINVCCGGIVGLGESVHER
                     AGLIAELANMEPYPDSVPINNLVKVEGTPLAGNEELDPFDFVRTIAVARITMPKAMVRL
                     SAGREAMDDALQALCFMAGANSIFYGEKLLTTDNPEADADRKLLARLGMRVEVQDHMHH
                     SADAGHSHSSHCHIDITPAD"
     PFAM_domain     complement(19655..19927)
                     /aSDomain="BATS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06968.15"
                     /description="Biotin and Thiamin Synthesis associated
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_176_0031"
                     /evalue="3.00E-20"
                     /label="ctg1_176"
                     /locus_tag="ctg1_176"
                     /protein_end="330"
                     /protein_start="239"
                     /score="72.3"
                     /tool="antismash"
                     /translation="PINNLVKVEGTPLAGNEELDPFDFVRTIAVARITMPKAMVRLSAG
                     REAMDDALQALCFMAGANSIFYGEKLLTTDNPEADADRKLLARLGM"
     aSDomain        complement(19655..20542)
                     /aSDomain="TIGR00433"
                     /aSTool="tigrfam"
                     /description="bioB: biotin synthase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_176_0002"
                     /evalue="2.60E-125"
                     /identifier="TIGR00433"
                     /label="ctg1_176"
                     /locus_tag="ctg1_176"
                     /protein_end="330"
                     /protein_start="34"
                     /score="415.5"
                     /tool="antismash"
                     /translation="LFALPFNDLLFQAQQVHRANFDANAVQLSTLLSIKTGGCPEDCSY
                     CPQSARYDTGVEAEKLMPIDEVLEAASRAKQNGASRFCMGAAWRNPKPHQLDAVADMVR
                     GVKAMGLETCVTLGMLKQEQAAQLKDAGLDYYNHNLDTAPEFYGEIITTRTYQDRLDTL
                     EHVRDAGINVCCGGIVGLGESVHERAGLIAELANMEPYPDSVPINNLVKVEGTPLAGNE
                     ELDPFDFVRTIAVARITMPKAMVRLSAGREAMDDALQALCFMAGANSIFYGEKLLTTDN
                     PEADADRKLLARLGM"
     PFAM_domain     complement(19982..20437)
                     /aSDomain="Radical_SAM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04055.23"
                     /description="Radical SAM superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_176_0030"
                     /evalue="2.40E-17"
                     /label="ctg1_176"
                     /locus_tag="ctg1_176"
                     /protein_end="221"
                     /protein_start="69"
                     /score="63.9"
                     /tool="antismash"
                     /translation="TGGCPEDCSYCPQSARYDTGVEAEKLMPIDEVLEAASRAKQNGAS
                     RFCMGAAWRNPKPHQLDAVADMVRGVKAMGLETCVTLGMLKQEQAAQLKDAGLDYYNHN
                     LDTAPEFYGEIITTRTYQDRLDTLEHVRDAGINVCCGGIVGLGESVHE"
     CDS             complement(20687..21481)
                     /NRPS_PKS="Domain: ECH (11-254). E-value: 5e-54. Score:
                     175.0. Matches aSDomain: nrpspksdomains_ctg1_177_ECH.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 230.6; E-value:
                     2.8e-70)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_177"
                     /transl_table=11
                     /translation="MNAFETLAFAQHGAVATLTLNRPDVRNAFNETVIAELTGAFRALA
                     QEPSVRAIVLAGNGPAFCAGADLNWMKKMAGYSDDENRADALRLAEMLRAIYTCPKPVI
                     ARVQGDTYAGGVGLVAACDIVVAVDTANFCLSEAKLGLIPATISPYVIRALGEQASRRY
                     FITAERFSAAEAHRLGLVHELVSADTLDAKVGDITAALVANSPNAVRESKRLVREVSGA
                     AVNDALLADTADRIAAIRASEEGREGVQSFLGKRKPNWLLPA"
     PFAM_domain     complement(20702..21448)
                     /aSDomain="ECH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00378.22"
                     /description="Enoyl-CoA hydratase/isomerase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_177_0032"
                     /evalue="3.30E-58"
                     /label="ctg1_177"
                     /locus_tag="ctg1_177"
                     /protein_end="260"
                     /protein_start="11"
                     /score="197.1"
                     /tool="antismash"
                     /translation="HGAVATLTLNRPDVRNAFNETVIAELTGAFRALAQEPSVRAIVLA
                     GNGPAFCAGADLNWMKKMAGYSDDENRADALRLAEMLRAIYTCPKPVIARVQGDTYAGG
                     VGLVAACDIVVAVDTANFCLSEAKLGLIPATISPYVIRALGEQASRRYFITAERFSAAE
                     AHRLGLVHELVSADTLDAKVGDITAALVANSPNAVRESKRLVREVSGAAVNDALLADTA
                     DRIAAIRASEEGREGVQSFLGKRKPNW"
     aSDomain        complement(20720..21448)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_177_ECH.1"
                     /evalue="5.00E-54"
                     /label="ctg1_177_ECH.1"
                     /locus_tag="ctg1_177"
                     /protein_end="254"
                     /protein_start="11"
                     /score="175.0"
                     /tool="antismash"
                     /translation="HGAVATLTLNRPDVRNAFNETVIAELTGAFRALAQEPSVRAIVLA
                     GNGPAFCAGADLNWMKKMAGYSDDENRADALRLAEMLRAIYTCPKPVIARVQGDTYAGG
                     VGLVAACDIVVAVDTANFCLSEAKLGLIPATISPYVIRALGEQASRRYFITAERFSAAE
                     AHRLGLVHELVSADTLDAKVGDITAALVANSPNAVRESKRLVREVSGAAVNDALLADTA
                     DRIAAIRASEEGREGVQSFLG"
     CDS             complement(21478..22299)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_178"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.7e-12, bitscore:
                     45.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEEVIEIPKSVGIFTVKLETTIFKPAGNGPFPLIVLNHGKALGN
                     PAFQSRARYSAQVAPLVARGYVVVLPMRQGFSKSGGAYIGGGCNVESNGTVQAEDVVAT
                     LDYMTKQPYVDRDRIVIMGQSHGGLTTMAFGTIDYPGVRGLVNFAGGLRNDSCVAWEIN
                     LVRAFGNYGKQSHYPSLWFYGDNDSYWPKPLPDRLFAAYTEAGGKGRMVDYGNFQGDSH
                     GMFASRAGLSIWLPEVDAFLRELGLPAGPVQTAAAPDNAASTQSGANKDPQ"
     PFAM_domain     complement(21898..22140)
                     /aSDomain="Peptidase_S9"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00326.23"
                     /description="Prolyl oligopeptidase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_178_0033"
                     /evalue="4.20E-12"
                     /label="ctg1_178"
                     /locus_tag="ctg1_178"
                     /protein_end="134"
                     /protein_start="53"
                     /score="46.1"
                     /tool="antismash"
                     /translation="YSAQVAPLVARGYVVVLPMRQGFSKSGGAYIGGGCNVESNGTVQA
                     EDVVATLDYMTKQPYVDRDRIVIMGQSHGGLTTMAF"
     CDS             complement(22431..24038)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059:acetyl-CoA carboxylase, carboxyl transferase,
                     (Score: 531; E-value: 5.7e-161)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_179"
                     /transl_table=11
                     /translation="MPTLDTKLNPRAEDFKANADAMRTLVADLRDKVARIAQGGGDDAR
                     AKHLARGKLLPRDRVQQLLDPGTPFLEFSQLAAYGMYDDAAPGAGIITGIGRISGQECV
                     IVCNDATVKGGTYYPMTVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDRDHF
                     GRIFYNQANLSSKGIPQIAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAA
                     TGEVVSAEDLGGADVHTRLSGVADYFANNDSHALAQARSIVAHLNRRKPEQVQIHPPVE
                     PRFPAEELYGVIPTDTRKPFDVREVIARIVDDSAFDEFKARYGTTLVCGFARIWGYPVG
                     IIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVT
                     AVATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVR
                     RDGIEAKGGQWSADEEAAFKAPIRDQYERQGHPYYASARLWDDGVIDPADTRSVLGLGL
                     SASLNAPIGDMNFGVFRM"
     PFAM_domain     complement(22467..23897)
                     /aSDomain="Carboxyl_trans"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01039.24"
                     /description="Carboxyl transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_179_0034"
                     /evalue="1.20E-153"
                     /label="ctg1_179"
                     /locus_tag="ctg1_179"
                     /protein_end="524"
                     /protein_start="47"
                     /score="512.4"
                     /tool="antismash"
                     /translation="HLARGKLLPRDRVQQLLDPGTPFLEFSQLAAYGMYDDAAPGAGII
                     TGIGRISGQECVIVCNDATVKGGTYYPMTVKKHLRAQEIAEQNHLPCVYLVDSGGANLP
                     NQDDVFPDRDHFGRIFYNQANLSSKGIPQIAVVMGSCTAGGAYVPAMSDESIIVKEQGT
                     IFLAGPPLVKAATGEVVSAEDLGGADVHTRLSGVADYFANNDSHALAQARSIVAHLNRR
                     KPEQVQIHPPVEPRFPAEELYGVIPTDTRKPFDVREVIARIVDDSAFDEFKARYGTTLV
                     CGFARIWGYPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYEN
                     EGIAKNGAKMVTAVATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMG
                     GEQAASVLATVRRDGIEAKGGQWSADEEAAFKAPIRDQYERQGHPYYASARLWDDGVID
                     PADTRSVLGLGLSASLNAP"
     CDS             complement(24069..24506)
                     /locus_tag="ctg1_180"
                     /transl_table=11
                     /translation="MSAQAKPIHPTDACPCGGVAYARCCCPFHAGEAVPATAEQLMRSR
                     YSAYVLGDTAYLRRTWHPSTCPANLETSEADAAATRWLGLDVKRHVPQDATHATVEFVA
                     RYKVGGRAHRLHETSRFVRLDASGAESAEGRWLYVDGTFPD"
     PFAM_domain     complement(24084..24398)
                     /aSDomain="UPF0225"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF17775.3"
                     /description="UPF0225 domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_180_0035"
                     /evalue="6.80E-28"
                     /label="ctg1_180"
                     /locus_tag="ctg1_180"
                     /protein_end="141"
                     /protein_start="36"
                     /score="97.5"
                     /tool="antismash"
                     /translation="TAEQLMRSRYSAYVLGDTAYLRRTWHPSTCPANLETSEADAAATR
                     WLGLDVKRHVPQDATHATVEFVARYKVGGRAHRLHETSRFVRLDASGAESAEGRWLYVD
                     G"
ORIGIN
        1 gcgtgtcgag cagcggtgcg gtgaatttgc cgcccgaggc ttcgtcggtc ttgaagccac
       61 tgctgcccgt gaccgtgtgg gtcggcaggg tggccgttac cgaatccttc ttggtttccg
      121 ccacggccgg tgtggccgcc acggcaaagc tcatggcccc tgtcaggtat cccaccaccg
      181 actgttcggc gcgcttgcgt tccgtctgtg ctgcttgcat ggcttggtgc ccgctcccct
      241 gaaaaatctt gttacatgtt tggcgcaaat gagaattgtt atcgttcgca tgtgaaggag
      301 tcaacgcaga atctgtcgat ttccttatcg gctgaagaaa atctccgata aatcaatgtg
      361 ttatgcgcca cgagccgtgg ggtgcggcaa aacgcagcat gttttgtgtt cgaaggcttc
      421 catttattca agcagatgat ttagtattgc cgggcaggct gtccaaccga atctctcttg
      481 caaggtgagc atcgcgtgag cacggacccg gaactcctca tcgagcagcg cgaccaggcg
      541 ctgtggttga ccattcagcg cgaagatcgc cgcaacgcga tcaacggcgc ggtgcttgaa
      601 gcactgatgg cagcgctggc cgatgccagc cgcaacaccg cggtgcgtgc cgtggtgctg
      661 accggcgctg gcacgcgcgc cttctgtgcc ggggctgatc tgcagagcgg ccaatctttc
      721 cgctttgact attcccagcc gcaccagggc ctggcggatc tgtttcggca ggcgcgccgc
      781 tgcaccgtgc cgctcatcgc acgggtgaat ggcgcatgca tggccggtgg catgggtttg
      841 ctggcgatgt gcgacatggc ggtggccagc cgtagcgcca tgtttgggct gcctgaggtg
      901 aaggtcggac tgttcccggc gcaggtgttg gccgtgttgc aacatcagct gccgcgtcgt
      961 ctgctcaacg agctgtgtct gaccggcgag cctatgagcg cagaccgtgc cctcgccgcc
     1021 ggcctgatca acgaagtggc cgaacccgaa gcgctcgatg ccgctgtcga tgcgctgctc
     1081 gcgcggctgc tcgacaaatc gccgtcggcc atccggcgcg ggttgtacac gctcaagcag
     1141 gttgagcatc tgagcttcga gcaggcgatg gcctttaccg aaagccagat cggtctgttt
     1201 gccttgaccg aggacgcgca ggaaggtcag gccgcctttc gcgagaagcg cgcccccaac
     1261 tggacgggcc gctgacatgc gtaaagacac ggtttccatc ggtggcgcca gcggcttttg
     1321 gggcgacagc gtgaccgggc cgatgcagct ggtcgcctcc ggccgcatcg acttcctcgt
     1381 cttcgatttc ctagccgaac tgaccatgtc gctgctggcc agcgcgcgca tgaagaacgc
     1441 ggagctgggt tatgcgaccg acttcgtgag cgtggcgatg cgcgcggtgc tcaaggacgc
     1501 gctggcgcag aacatccgca tcatcgccaa cgcgggcggc gtgaacccgc gcggttgtgc
     1561 cgccgctctg caagccctgg ccgatgagct gggtgtgagc gtgcgcattg ccgtggtgga
     1621 aggcgatgac gtgatgccgc tgctgcccgc gctgcgcgac gaaggcgtgc gcgagctgca
     1681 aagcggccgc ccgctgcccc acaaggtggt aagcgccaat gcgtacctgg gtgcgttgcc
     1741 gatcaaggcg gcgctcgatg cgggcgcgca ggtggtcatc acaggccgat gtgtcgacag
     1801 cgcggtcacg ctcggtgcgt tgatgcacag ctttggctgg gccgtggatg actacgaccg
     1861 cctcgccgcc ggcagcctcg ccggacacat cctcgaatgc ggctgccaag gcgccggtgg
     1921 cctgcatacc gattgggaag ccgtgcccga ctgggcgcac agcggctacc ccatcgtcga
     1981 gtgcggggct gacggcagct tcatcgtcac caagccggaa ggcaccggcg ggctggtgac
     2041 gcccgccacc gtgggtgagc agttgctgta cgagatcggc gaccccgcgc gctatgtgct
     2101 gcccgatgtc gtctgcgatt tcacgcaggt gacgatgacg caggccggcg agcatcgcgt
     2161 ggaagtgcac ggcgctcatg gcattgcacc cacgcccgac tacaaggtga gcgctaccta
     2221 cgctgacggc taccgcgcca ccggccagct caccatcgtc ggcgtcgacg cggaccgcaa
     2281 ggcgcaccgc acggcggaag cgattttgga gcgcacgcgc ggcctgttcc acaagctcgg
     2341 tctgccggac tacagcgcca cgcacatcga gacgctcggt tcggcctatc tgttcggccc
     2401 gcatcaaccc gaggtgccac gctttgaatc ggtgatgtgg ctggcggtgg cgcatccgaa
     2461 caagcaagca ttggagttgt tcgcccgcga gatcgcaccg gccggcacat cctgggcacc
     2521 cggcacgacg ggggccggtg ggcggccgag cgttgtaccc gccgtcaagc aatacgcttt
     2581 cctgatcgac aaggcgcgcg tgcagccacg tgtgacgttg ctgggcggtg agagcttcga
     2641 tgttgcggtg ccgacgggcg gtgcgccatt ggaagcctca accgccgcga cgatgacggc
     2701 agcactgccg accggcccga cgcgcgaagt cccgctcatc gaactcgcct acgcccgcag
     2761 cggtgacaag ggcgacacct ccaacatcgg cgtgatcgcc cgccggccgg aagacctgcc
     2821 gctgttgcgc gcacagttga ccgaagacgc cgtcgccgcc tatctcgcac acgtcgcgcg
     2881 tggccgcgtg acccgctacg acctgccggg cattcacgca ctcaacttcg tctgcgagcg
     2941 ggcgctgggc ggtggtggca tggcgtctct gcgcaacgat ccgctgggca agggcatggc
     3001 gcaggtgctg ctgacgatgc cggtgcgcgt gccggtcgat catccttaac cgacggggcg
     3061 accatgtaca caggtctgct gacatccgtg ctcttcaatg ccgagcacga cacctttcgt
     3121 gagaccgtgc gccgctttgt cgacaaggcg gtgttaccga acatcgatgc ctgggaagag
     3181 gcggaaacct tcccgcgcga gctgtatcgc aaggcagccg aactgggttt gctcggcatt
     3241 ggttttccgg aggagtacgg tggcacgcct gctgacctgt tccttgaact cgcgatgatc
     3301 gaagagctga cgcgcgccgc cagtggtgga ctgctcgctt cgctgttcag ccacacgatc
     3361 ggcgcaccgc ccatcgtagc gggcggttct gcagagctga aatcgcgcgt gctgcccgac
     3421 atcctctcgg gcgagaagat cagcgcgttg gccatcaccg agccgttggg cgggtcggat
     3481 gtcgccaatc tgaccacgcg tgcggtgcgt gatggcgatc actacatcgt caacggcagc
     3541 aagatcttca tcacctccgg catgcgcgcg gactacctga ccgtggctgt gcgcacgggc
     3601 ggccctggcg cgggtggcat atcggtgctg ctcgtggatg gcgatacgcc gggcctgtcg
     3661 cgcacaccgc tcaagaagat gggctggtgg tgctccgaca cggcgcaact gcacttcgac
     3721 aactgccgcg tgcctgtagg caacctgctc ggtgcggaga accgcggctt cgagctggtg
     3781 atgcgcaact tcaaccatga acgtttggcg ctggcgatgc aggcctatgg cctcgcgcgc
     3841 acgtgcctgg ccgaagcggt ggagtgggcc agccagcgcg aaaccttcgg caagcgcctc
     3901 gtgcaacacc aggtggcgcg gcagaagctg gtggcgatgg ccacgcgcat cgaagccacg
     3961 cgcgcattgc tcgaggacct gatgcgccgc atgcaggcgg gcgagtcgcc cgtcgcgcaa
     4021 ctgtgcatgc tcaagaactt cgccacgcag agcctgcagt tctgcgccga cacggcggtg
     4081 caactgctcg gcggcatggg cttcatgcgc ggcacgaagt cggaacggat ctatcgcgaa
     4141 gtgaaggtct acatgatcgg cggcggcgcg gaggaggtcc tgagtgatct cgctgctcgc
     4201 cagcttggtt gggtttgagg agacacacat gtatcgctca gtctttcgac cggggttgtt
     4261 cctggggcaa gtggcagtgg tgacgggtgg tggcagcggc atcggccggt gcaccgcgca
     4321 tgagctggca tcgctcggcg cggcggtcgc gctggtgggg cgtaatgcgg acaagctcgc
     4381 cgccgtgcgc acggagatcg tcgaagccgg cggcaccgcg cacgcctatg tctgcaacat
     4441 ccgcgacgag gctgccgtgc aggcgacggt cgcgcagatc ctcggcgagc acggccgcat
     4501 cgatgcgctg gtcaacaacg cgggcgggca gtttccgtcg ccgctcaagg acatctccgt
     4561 caaggggtgg gaggccgtcg tgcagaccaa cctgaccggc ggtttcctga tggcgcgcga
     4621 gtgcctgaac caggcgatgc agcagcgcgg cggcgccatc gtcaacatcg tcgctgatat
     4681 gtggggcggt atgccgaaca tggggcactc gggcgcggcg cgtgccggca tgatcaactt
     4741 tacggagacg gccgcattcg agtgggcgca gtacggcgtg cgcgtgaatg cggtggcgcc
     4801 gggctatgtg gcgtcgtcgg gcatggacgc ctatccgccg tggatggccg agaccatccg
     4861 cagcatgccg cgcacggtgc cggcggggcg ctttgccacc gaggcggagg tgtcgtcggc
     4921 catcgtctac ctgttgtcgg aagcggcggc gttcatcacg ggcacgacgc tgcgcgtgga
     4981 cggcggccgc cccaacgtgc ggcccggcac gcccatgccg gcaccgcgtc atggcgccgc
     5041 accgttcaac ggcttccacc tggccgccac gcccaaggtg ctgcaagaca aggagaccga
     5101 tgatgccggt gcttgagtcg cgcatcgtcc cgcaaagcga cgcctaccag cagaaccacg
     5161 ccgcgctcac ggaactcgtc gaccaactgc gcacgctgga gaaccgcacg cgctacaagt
     5221 ccgaagcctc gcgcgcacgc ttcgagcagc gcgggcagtt gctaccgcgt gaccggctcg
     5281 gccgcctgct cgatgccggt gcaccgttcc tggagctgtc ctcgctggct ggcttctgcc
     5341 tcgaccacgc agacccagca cgctcgattc ccggtggcgg cttcatcgcc ggcatcggct
     5401 gggtgagcgg cgtgcgcgcg atgatcatcg tggacgacgc gggcatcgat gccggtgccg
     5461 tgcagccgat gggcatcgag aaattccagc gcgcgcaggc catcgcgctg gagcagaagc
     5521 tgccgttcat ccatctcgtc gaatcggctg gcgccaacct gctgacctat cgcgtggaga
     5581 ccttcatcca cggcggcagc ggcttctact ggctcgcgcg gctgtcggcg gcgggcattc
     5641 cggtgatcag cgtggtgcat gggtcgagca cggcgggcgg ggcgtatatg cctggtctct
     5701 cagactatgt ggtgatggtg cgcgatcgcg cgcgcgcgtt ccttgccggt ccgccgttgc
     5761 tcaaggccgc caccggcgag atcgccaccg aagaggaact gggcggcgcc gagatgcacg
     5821 ccaccacctc gggcctcgcc gaatacctgg ccgaagacga cgccgatgcg ctgcgcatcg
     5881 cacgcgaact cgttgctgcc ctggattgga accgcgatgt gccggtagcc gatcgcccct
     5941 acgcaccgcc gcgtttcgat gcggaagagt tgctcggcat tgcactcacc gatcatcgca
     6001 agccgctcga catgcgcgaa gtcattgcgc gcatcgccga tggctccgac ttcctcgagt
     6061 tcaagccgga ctatggcccg gctacgatca ccgggcacgc cgccatctgc ggcatgcacg
     6121 tcggcatcat caccaacaat gggccgctgg acccggcggg tgccacgaag gttgtccact
     6181 tcattcaggc gtgctgccag tccgatacgc cgctgctgta cctgcaaaac accacgggct
     6241 tcatcgttgg caagcagtcc gagcaggcgg gcatgatcaa gcacggctcg aagatgatcc
     6301 aggcgatggc caacgccacc gtgccgcgca tcaccgtcca ttgcggcgca tcgttcgggg
     6361 cgggcaacta tggcatgtcg gggcgcggct tcttcccgga tttctgcttc agctggccca
     6421 acgccaagac cgccgtgatg ggcgcggagc aggccgctgg aacgatggcc actgtcatgg
     6481 ccgccagcat gcaacgcaag acgcagacca tcgaccacga cgccatcgag gcgatgcgcg
     6541 ccaaggtgat cgacaccttc gagcggcagt ccggcgcgtt cacggtgtcg ggccgcctgc
     6601 tggacgacgg cgtgattgac ccgcgcgaca cgcgcaaggt tctggcctgc gtgttggccg
     6661 tctgcgacga agcgcgcagg cgcacgctgc atcccatcca atttggcgtt gcccgaccgt
     6721 agcgccaact catacgaaca acgcaaacag cccaaggcca ccggagcgag acaccatgca
     6781 cttcacccac gaacaccagg aactgcagcg caacctcaaa cgcttcatcg acagcgacat
     6841 caatccgtac gtggaagagt gggaagcggc cgagatgttc cccgccaagg cgctcttcaa
     6901 gaagatgggc gatctgggct ttctcggcat tgccaagccg accgagttcg gcggcctggg
     6961 cctcgactat tcgtatgcga tggcgatggc ggaaacgctc ggccacatcc actgcggcgg
     7021 tgtgccgatg gcgattggcg tgcagactga catggcaacg cccgcgctcg cgcgcttcgg
     7081 ctccgatgaa ctgcgtgcgc agtttctcgc gcctgcgatc agcggcgatg cggtggcgtg
     7141 cgtcggcgta tcggagccga gcgccggttc cgatgtggcc ggcatcaaga ccaccgcacg
     7201 caaggatggc gacgactaca tcatcaacgg cagcaagatg tggatcacca acagcctgca
     7261 ggccgactgg atgtgcctgc tggccaatac gtcggatgac ccggcgcacc gcaacaagtc
     7321 gctgatcatc gtgccgatga acacgaaggg cgtatcggtc ggcaagaaga tccgcaagat
     7381 cggtatgaac tcgtcggaca ctggcctcat ctactttgac gacgtgcgtg tgccgcagcg
     7441 ctaccgcatc ggtgaagagg gcaaaggctt cacgtaccag atgctgcagt tccaggagga
     7501 gcgcatgtgg gccgccgcca gcagcctgca gacgatgatg atgtgcatcg acagcaccat
     7561 cgagtacggc cgggagcgca agctgttcgg tgccagcctg ctcgataacc agtgggtgca
     7621 cttcaagctg gccgaactga agaccgaggt ggaggcgctg cgtgcgctca cctaccgcgc
     7681 gtgcgatctc tacatcaacg ggcaggatgt gacggagctc gcatcgatgg ccaagctcaa
     7741 ggccgggcgc ctctcgcgca tcgtgcccga cgcctgcctg cagttctggg gcggcatggg
     7801 cttcacgtgg gacaaccccg tctcgcgcta ctaccgcgat ggacgcctgg gttctatcgg
     7861 cggcggcgca gatgaggtga tgctcggcat catctgcaaa tacatgaaca cgctaccggg
     7921 caagaagggc tgagcaatgg gcacgccgca cgctgctttc cgcacagtcc tgatcgccaa
     7981 ccggggcgag atcgcgctgc gcatcctgcg taccgcgcgg cgcctcggca tgcgtaccgt
     8041 tgccgtgtac tccgatgccg accgcgatgc cccgcattgc cgcgcagcgg acctcgcctt
     8101 gccgattggc gcgtcgcaac cacaggcgtc ttacctgaac atcgccgcgt tgctggaggc
     8161 ggcgcgcaag tccggcgcgc aggctgtgca tcccggctat ggcttcctgg ccgagagcga
     8221 tgcctttgcc aatgcctgtg cagaagcggg ccttgtcttt atcggcccac ctgcggaagc
     8281 cattctcgcg atgggcaaca aggccggcgc caagcgcttg atggaggccg ccggtgtgcc
     8341 gtgcgtgccc ggctaccagg gcgaagacca atccgatgcc cgcatgcagc aggaagcgga
     8401 acgcatcggc tacccggtga tgatcaaggc cgcagccggc ggcggcggac gcggcatgcg
     8461 gcgtgtggat cgcgcagaag actttgctgc cgcgctgcag tccgcacgtt ccgaagcgga
     8521 gaacgcgttc gcttccggcg agctgatcct cgaaaaggcc atcgtcgagc cgcgccatat
     8581 cgagatccag gtgtttgccg ataagcacgg caacgtcgtc cacctgggcg agcgtgactg
     8641 ttcggtgcag cgccggcatc agaaggtgat tgaagaatcg ccatcgcctg cggtgtcgcc
     8701 ggagttgcgt gcacgcatgg gcgcggtgtc ggtagccgca gcacgcgcca tcggttacgt
     8761 gggcgccggc acgctggagt ttctacttgc cccggacggc gcgttctact tcatggagat
     8821 gaacacgcgc ctgcaggtcg agcatgcggt gacggaagcg gtggtcggcg ttgatctggt
     8881 cgagtggcag ttgcgcgtgg cgctgggcga gccgctgccg ctgtcgcagg acgccatcga
     8941 tgcgcgtcgc gcgcaaggtg gtcacgccat cgaagtgcga ctgtgtgcgg aagacccgca
     9001 gcagaacttc ctgccgcaaa gcggcaccgt cgcgcgctgg cgtgcaccgc gcgaggtgcg
     9061 tacggaccat gcgttggcgg atgggctggt ggtctcgccg tactacgact cgatgctcgc
     9121 caagatcgtc gcgcacggca tggatcgtgc cgatgcgtgc aggcggttgg tgcacgcgtt
     9181 ggatgattgt ttgctgctgg ggctgccaac caatcgtgcg ttcctgcgcc agtgcgtggc
     9241 gcatccggcg ttccttgctg gcgacgtctc caccgcgttc atcgaccggc attttccggt
     9301 ggcgatgcgc caggcggccg tacccgatgc agcggtctgc caggccgccg cagtgctgct
     9361 cacgcactcg cgcaaggacg ccgtgcgccg ctatcccacc gagctgcagg gctgggccag
     9421 cagccgcacg taccccacgc tgtgccgctt cacgctcgac ggcgaggcga tcgagatgcg
     9481 cgtgcgtgca ctcgccgtgc aacgctggga agtgagctgg gacggcggca ccgcgcaagc
     9541 ggaaatcgtg tccgaagccg atggccgcct cacgctcgcg ctgggcgaca ggctgtaccc
     9601 gatcgaatac gcgatcaccg gaaccgctta ccacttcgtg ttggatggcc gggaacacac
     9661 cgccatcgac accacctacg ccaaggcgga acgcaacggt gcgcaagccg gcagcggccg
     9721 catcagcgca ccgatgaatg gccgcgttgt cgctgtccac gtgacggagg gcgaggccgt
     9781 ctccgctggc caattattgc tggtggtcga agccatgaag atggagcaca gcattgccgc
     9841 gccgctcgcc ggcgaggtga agggcctgtt cacccaggtc ggcgcacagg tcgcgccggg
     9901 cgggttgctg atggagattg ccgcggcctg agggctgcat cgtcgttgtt gtcgtccatc
     9961 gtttcgtcgt gcagttcatg cggtccacag gagacgtccc atgtccgaag ccacgccaga
    10021 caccacgctt gaagccaacc tgctgaaccg ggtgacgctg ggcgatacgt tgcatcgcag
    10081 cgcacgcaag ttcggcgcga aggtcgcgtt ggtcgatggc ccgcgccgca tgacgcatgc
    10141 ccagctcaat gccgacagca accgctacgc ccatcacctg ctggccagtg gcctcaagcc
    10201 gggtgacaaa gtggcgatgc tttgcggcaa ctcggcgcag tttctggtgg cggcctacgg
    10261 catcatcaag gcggggctgg tgtgggtgcc catcaacgcg atgcttgggc cagacgatgt
    10321 gcgctacatc cttgagcatg ccgaagtgcg gcacgtggtg atcgatgcgg cgctgtaccc
    10381 ggtgctgcgt gaaacgttgg cagcgctcgg gctacctggg caccagtgct tcggtgagcc
    10441 agccgcaggt ggcccggaga ctgtcgagca ggcactgcaa ggtcacgccg acacgctgcc
    10501 cgccgtgatg atcgatgacc gcgatctcgc gctcatcatg tacaccagcg gcactacggg
    10561 ccggcccaag ggcgcgatgc attcgcaccg ctccgtgcac gcggcgctga tgtccaacat
    10621 cgccggcctg aacctgaacg agaaagacgt gttctcgtgc atcctgccga tgtttcattg
    10681 cgcccagttt tcgaccgcag cttccgcgat gacagtgggc gccacgcttg tcatccagcg
    10741 cggcttcgac ccgaccgcgc tgcttgacgc gattaccaac gagcgcatca cgcagctatt
    10801 tggcttgccg ctcatgtacg ccgcgctgct gcaccatccg ctgcgcgcgc agcgcgatct
    10861 ctccagcctg cgcttgtgcc tgtatgccat ggcgccgatg gccaagccgc tgctcgaacg
    10921 gctgattgcc gaggtgtgtc cgaactttgc gcttggctct gggcagacgg aaatcttccc
    10981 gatgacgatg tactttgcgc ccgaccagca actgcagcgc accggcaact actggggaca
    11041 gccgtgcatg gtgaacgagg cggcggtgat ggacgacgag ggcaacctcc tcggccccaa
    11101 tcagttgggc gagatcgtgc atcgcggccc caatgtcatg ctcggctact ataaagaccc
    11161 gcaggccacc gccaacgcgc gccgcttcgg ctggcaccac acgggcgacc tgggcatgtg
    11221 ggacgccgac ggccagctcc agttcaagga ccgcatcaag gacatgatca agaccggcgg
    11281 cgagaacgtg ccgtcgctca aggtggagga ggtgctgttg cgccatccgg ctgtggcgaa
    11341 tgccgcagtg gtcgggttgc cgcatgcgca ttgggtggta gcggtggcgg ccttcgtctg
    11401 cctcaagccg gatgcgcagg cggatgcgac agcgttgcag gcacactgcc gcgaacatct
    11461 cggcagcttt gaagtgccca agcacatcag cgtggtcgac aagctgccca tgacggccac
    11521 cggcaagatt cagaagcacg tgctgcgcag cgccaaccag acgctgttcg agagcgacgc
    11581 gcgttgagga aaactaagct gccggctgcg gcggcgtgcg caggatgaag agcaccgcct
    11641 gatcggccag tgcatcgatg ctgatacccg caccggcctg ataccactgc gccgtccagt
    11701 tgagcgcgcc aaacatcagc aggcggtcca ccggcgttgg ttgtgcccag tcgccggacg
    11761 cgcgcaggcg gtcgatgacg tggttccaga tgccctcgta gcggtccttg agcgcgatga
    11821 tgcgttcctg cgcgtgcgca tcgagtgagc gccactcgta cagcatcacc ggaatgaaat
    11881 cctgattggg cgccaggatc gtgtagaggt gcgcgcgcac cagttggcgc atcgcctcgc
    11941 gcgggggctg gccatcaatg tcgatcgctt cgatgtcggc cagcgccacc gtcaggccgt
    12001 gctcgatcac ggcttgcagg atttcctgct tggtcttgaa gtgatagaac cagctgcccg
    12061 catgcacacc cgtggcggcg gcaatgtcgc gcaccgtggt gttgccgtac cccttctcgc
    12121 ggaacagtct ggcggattgt tcgatcagcg cgcggcgcag gccttcgttg gcatcctgtg
    12181 cggggcggcc gcgcttgcgg cgcggtgcat cggcgtccgt ggtggattct gttaggttgg
    12241 gtggtgcggg tttcgacatg cctggcgaag agaaacggct tcgctgcatt gtagcgaccg
    12301 gcagctcaat cgcggttgcg gatttgccct tgctcgaccg tggcggcacc ggccttgacc
    12361 agcgcgccga tggcggcatc cagcaggtcc gtcatcgact ggtttgcaaa gaagcgcgcc
    12421 tgcaggcgtg tcatcagcgt ggtctgcgtg aaccacgcga acaacgcttc gtgcgagagc
    12481 gcctgctgct ccagcagctt gaacttcacc agcacgcgaa tggcatgcag cgcattgcgt
    12541 tctgggtccg cacgcagata cgcgagccgc ccgagcgatg cgtcgatggc ggcgccaact
    12601 tcagtgaacg gccggccatg tcccggaatc accacgcgca catcgagctg cgcgatgcgc
    12661 tccagaatgg cctgctgttc tgcaaagccg ctctcgccct ccagctcggg aaagatgatg
    12721 ccgaaaccgc gctcccacag tgcatcggct gagagcagca cgcgcgactc cgggctgtag
    12781 agaatgacgg cgttgggatc atgccccggc gcgctgatga cctgccagtc gaagccgccc
    12841 aggtgcacgg tcatgccgtc ggccaggccc gcatcggcat cgctgtcggg cagcgtgaag
    12901 cgggcgcatt cctggccggt ggggccgtag ctgagggcgt cggtgtccca gcggcgcaca
    12961 tcgtcgacct gcgcagcggg cacgcgggtg tggcagctgt acagtgcctg cagcgccgcg
    13021 ttgccgccgc agtggtcgga gtgcaggtgc gtgttcagca gacggcgtag tggcttgcct
    13081 tgcagcgcgt gctgcaccag cgccaccgtt tgcggtgcgt gcgtgaggta gccggagtcg
    13141 accagcgcgc agccgccgtg ctcgccgtca ccaacctcgt catcgaagaa gaggatgttg
    13201 ttggacgaca gccagccgcg ctcgaacacg cgcatcgaat tggggagggt gatgatgtcg
    13261 tgttcggcca tgttggtgtg gggtcaggcg cggggggtgt cgttgagcca ggcgcaggcg
    13321 cgttcgggca gcgtctgcca gacggcgagg cgcgccgcgt cgctcatggt cgaccaggcg
    13381 gcaatctcgt cgatcgtgcg catgcaaccg aggcataggc cacgcgcgtc atccatcttg
    13441 cacacgctga tgcacggcga cgtgaccggc tgtgcgcgct cggcttgcgc gcggctattg
    13501 cgcagcttgc ccagcgagag cttcagttgt gcgcgggtgc aactgtccat cgatgttcga
    13561 tcaatcacgc tgggcaatgt cggccacagg cgcgccggtc atcgcttcca gctcggcggg
    13621 cgtgaggttg aacaccgcgt gcggatggcc ggcggcggcc cacacgctgg cgtactggaa
    13681 gaggtcttga tcgagcagca tgaccggttt gaccgcatgg ccgaccgggc acacgccgcc
    13741 aatcgcataa cccgtcttct cgcgcacgaa cttggcgtcg gccttggcga gtgcacccac
    13801 gtgcgcggaa acctttgcct cgtcgacccg attggtgccg ctggcaatca ccagcaccgg
    13861 cacgtcgtct ttggcgcggc ggaagatgat cgacttggcg atctccgcca ccgagcagcc
    13921 caggccggca gcggcttcag cagaggtctt gccggtggcc ggcagcatca cgatggcttt
    13981 ttcatagccg agcgtgcgca ggtggtccgc cacgcgctgg gcggattcgg gcaggggggc
    14041 gttcgtgtcg ggtgcggtca tcgtcgttgt tctttgtgaa ggttcagatg caggcctggg
    14101 cgatctggtc ttgcagcttg agcagcagtg cgcggcctgc gcgtgaagcg gtagggcgac
    14161 caatggcttg ggaaatgaaa tcacccgcca gcaccacctt gtccaggtcg atgccggtgc
    14221 ggatgccgag gccgtgcagc aggtacagca catcttcggt cgccacgttg ccggtcgcgc
    14281 ccttggcgta cgggcagccg cccagccccg ccaccgacgc gtggaagatg tggatgccga
    14341 cttccaggct ggcgaggatg ttggccagcg cttggccata cgtgtcgtgg aagtggccgg
    14401 agaggcggtc gatcgggaac gttgccgcag cggcttccat caccgtcttc acgcgcccgg
    14461 cggtgcccac gccaatggtg tcggcaatgt cgatctcatc gcagccgagg tccgccatgc
    14521 gcttgatcac atcgacgacc gacgacaccg gcacctcacc ctgatacggg cagcccagcg
    14581 agcacgagat cgacccgcgc acgcgaatgc ccgcatcctt ggcagccttg gccaccggca
    14641 cgaagcgttc gatcgattcc gcaatcgagc agttgatgtt cttctgcgca aaagcctcgc
    14701 tggccgcgct gaagatcacg atctcatccg cgcccgccgc cgcagcgcct tcaaagcctt
    14761 tcatattcgg cgtgagcacc gaatacagcg tgcccggccg gcgctggatg cgcgccatca
    14821 cgtcggcgcc gtcggccatc gccggcaccc acttgggcga cacgaacgac gcggcttcca
    14881 cgttgacgaa accggcgtcg gacagccggt tcaccagctc gaccttggtg tcggtcgaga
    14941 ccggcgcctt ctcgttttgc aggccgtcgc gcgggccgac ttcgaccacc ttcacaaatt
    15001 gcgggtagct catctcaata acctcgttgc agatcgacga tgccgacgat cggttcgcca
    15061 gcttccagcg cgcgaatctt ccgcgcgatc tgggcaatgc tcacttcgcg cagcgtcagc
    15121 gccgaaatat gcggcgtgat gtggatgcgc ggttcagtcc agaacgggtg atcgacgggc
    15181 agcggctcct tgcggaacac gtcgagcgcg gcgccggcaa tgtgcccgct gcgaacggcg
    15241 gccagcaggt cgtcttccac gacatgcttg ccgcgtgcca cgttgacgag gaacgcgccc
    15301 ggcgcaagtt gcgcgagcag cttggcgtcg atcacgttct cggtgtcggc ggtgagcggc
    15361 agtacgttca ccagcacgcg cgttccggag aggaagccgg gcagcgcatc ggccccggcg
    15421 cggcaatcga tgccgtcgat ggctttggtc gaacggctcc acccgcggac cggaaagccg
    15481 aagcccgcca gcgtcttggc aatgtgtgtg ccgagcacgc ccagccccag cacgccgacg
    15541 acaaactcgt cgcggttgaa cggcttgagg aagcgccaca tcttggcttg ctgctgacgc
    15601 tcgtactcgt cgagccggcg gaagaagcgc agcaccgcgt gcgtgacgta ttcgcccatc
    15661 tgcgcggcca tgccggcgtc gtccaggcgc acgatcggca gcccttcggg aatggcatcg
    15721 ggcgactgcg cacgcaggcc gaggatggca tcgacacccg cgcccaggtt gaacaccgcg
    15781 cgcaaatccg tgcgcccgcg cagcatgtcg gcaggcggct gccagactac ggcgtaatca
    15841 gcgtcctgcg ccgcaccgtg ctcccacacc gacagccgcg cttcaggcag cgcctgcgca
    15901 aaaccatcga gccagggttg gggcttgccg tcgggcgtgt agatctggat gtgcatgtgg
    15961 ggcgacttcg agtgcgggat ggatgctggt tgacgtatac gtcaagcagt gtagcagggg
    16021 ccgccgaggc gcgtggcggc tggttttagt gctgtccggg ccacaggtgc gcaaagtcga
    16081 aggacagttg tcggtggtgc cggatcgaca gcagatagat cgtttcaccg agatgggcgt
    16141 acaagacgag gtactcctga aggacgtact cgcgcagttc gccgtcggca acgcgtgcca
    16201 gttgacgttt cagttggccc tgctttgtaa gcgcctcgac cgatgtcgcc gtcctcgata
    16261 gcagcggtgg ccccatcgtc ggaaattgct ccagattggg aacaacggtc tccgtcaatt
    16321 catcgagcag gcggtcgtag ccttcgggaa attcgcgttc gatccagaac gcttcgatgg
    16381 cttcgaggtt gtgttcgaag ttctccgtca acttgacgga taagcgtggt ttgcgcgcca
    16441 tccgtcagct atgccttgct gccacgccgg cgcttcaacg cgccgagtgc ttgtcgggca
    16501 tccttgacgc gcccggcctc cacatcagcc aaccccttag cggcatcgtc cagcagcagc
    16561 agatgaatcc gtgcgcgttc aagctggtgg tagtagtcga gccgttgcgc gtcgatcagg
    16621 gctatatagc tctcgccgtt tttggtgacg atcttctctg cgccagcttt aacctgctcg
    16681 gccaactctg acaggttggc gcgcgcttgg gatagcggaa tcacgtcgcg tgctgaaaaa
    16741 gccatagcag cctcctcacg aaatcagtac ataattctgt acataataca cgcgttgaag
    16801 agtggaccgc ccaagcgcgc ggcggcccac tttggcgtca ctccgccggc ttaaacgcca
    16861 gcagttgcac gccttccgtc acctgatccc ccacgccata cagtacggac tcgactacgc
    16921 cgtccgccgg ggcggtgagc gtgtgctcca tcttcatggc ttccatgacg accagcggtg
    16981 cgcccttggt gacggtctgc cccggcgtgg cgagcacggc gatgaccttg cccggcatcg
    17041 gcgcggtcag cttgccgcct tcgtcgtcgg tctcgccggc gtgggcgagc gggtcgtgcc
    17101 gctccagcgt ccagtgcgcg ccgccggtga agacgtggaa ggcatcgcca tccacatgca
    17161 cctggccggt ggccttgtgc gagccgagcg cgacggtgaa ggtttcgccg tggcgttgcg
    17221 tggtgaaggg ggcttcatca ccgttggtct tcaggcgcga gccgtcgcgg ccatagatga
    17281 gcgtggcgtc gacggcttgt tcgccgtgcg tgaaacgcag tgcgcgttcg gccgcaccgt
    17341 tcaggcgcca gccgctgccg cgcgcccacg gcgaatgcgg atcgcgcgtg tctgtgcgca
    17401 ggctgcgcgc ctcgcgcgcc agcaacgcgg ccacggccag ggcgatggcg tcttgcggca
    17461 cgtccagcgc agcggggaac agcgtgtcgt ggttgcgcgc gatcaggccc gtatccagat
    17521 ccgctgtcgc aaacggcttc gatgccacca ggcggcgcag gaacgctacg ttggatgaca
    17581 gcccgactag atggaactcg cccagcgcct gcagcatgcg tgcgagcgct tcttcacggt
    17641 cgcggcccca gacgatcagc ttcgcgatca tcgggtcgta gtaggggctg atggcatcac
    17701 cttcgcgcac accggcgtcg atacgcacgg cggcgggttc gccattggcc tgcgcgccga
    17761 cggtgaactc caccgctgcc ggcgtgcgca gcaccttcag cgtgccgatg gagggcagga
    17821 aatcgcggtc ggggttttcg gcgtagatgc gcgcttcgag cgcatggccg tggatgtgca
    17881 gttcatcttg cgagcgcggc agcggctcgc cggaggccac gcgcaattgc cattcgacga
    17941 ggtcttcgcc cgtgatcatt tcggtgacgg ggtgctcgac ctgcaggcgc gtgttcatct
    18001 ccatgaagta gaacgtgccg tcttcatcga cgatgaactc gacggtgccg gcgcccacgt
    18061 agccgacggc gcgcgcggcg gccacggcgg cttcgcccat ggcgcggcgg cggtccagcg
    18121 tcatgccggg ggcgggggct tcttccaaca ccttctggtg gcggcgctgc acggagcagt
    18181 cgcgctcgaa caggtagacg gcatcgccaa agccatcggc gaagacctgg atttcaatgt
    18241 ggcgcgggcg cgtgaggtac ttctcgatca gcacgcggtc atcgccgaag ctgctggagg
    18301 cttcgcgctt gacggaggcc aatgacgctt caaacgcatc gcccgattcc accacgcgca
    18361 tgcccttgcc gccgccgcca gcgctggcct tgatgagcac ggggtagccg atgcggtcgg
    18421 cttgcgtgcg caggaaggcg gcgtcctggt tgtcgccgtg gtagccgggg acgaggggta
    18481 cgccggcttt ttccatcagt gctttcgcgg cgcttttgct gcccatcgct tcgatggccg
    18541 aggccggtgg gccgacgaag atgatgccgg catctgcgca ggccttggcg aaggcttcgt
    18601 tttctgagag gaagccgtag ccggggtgga cggcctgggc gccggtggcg agcgcggctt
    18661 cgaggatgcg gtcggcgcgc aggtagctgt cgcgggcggc gggttcaccg atgtggatgg
    18721 cttcgtcgca ggccgcgacg tggcgggcgt tggcgtcggc atccgagtag acggcgaccg
    18781 tgcggatgcc cagcttgcgg caggtggcag cgactcggca ggcgatttcg cctcggttgg
    18841 cgatgaggag tttggtgatc atttggtgtt tgtctccggt gttctctgca tcttctgcac
    18901 ttgtggtgca tccctttttt ggcttccgcc aaggaagggc cttgtagtcc atcccttgtt
    18961 tcatcccctg ccggggctga ctcacttttc tttgtcttgc caaagaaaag taagcaaaag
    19021 aaaggcgcgc ccgagatggc gaccccctcc ttgaatttgt gtaaccgggc ggagacgggg
    19081 aaaactcgct tcgctcagac agttccccgt cttatttccg cccgcttaca caaattcaag
    19141 gcgccatcta gggcaggaac gtcaacggcc aaaccgttgg tgtgcatgcg ctgtcaggct
    19201 ctcgtttgtt gctgtgtgct gctttgcttc gctcgcgatc ttcgactgct tttgcaggtt
    19261 cagcttcgcg tcttgctgcg tatctactac tgcgtttgtg ctccgatggt gtggccgttg
    19321 gagcccttga tggcgccttg aatttctgtt gcagagagga aaaaggaagg ggaactgttt
    19381 gagcgaagcg agttttcccc ttcccctctc tgcgacataa attcaagggg aagtcgccat
    19441 ctcgggcgcg cctttctttt gcttactttt ctttggcaag acaaagaaaa gtgagtcagc
    19501 cccggcaggg gatgaaacaa gggatggacc acaaacaaaa aaccatcccc catccaacac
    19561 atcagtccgc cggcgtaatg tcgatatggc aatgcgacga atgcgagtgc ccagcatcag
    19621 cgctatggtg catgtgatcc tgcacctcca cccgcatccc cagtcgcgcc agcagcttgc
    19681 gatctgcatc cgcctccggg ttatccgtcg tcagcagctt ctcaccatag aaaatcgagt
    19741 tagcccccgc cataaagcac agcgcctgca acgcatcatc catcgcctcg cggccagcgg
    19801 agagccgcac catcgccttg ggcatcgtga tccgcgccac cgcaatcgtg cgcacaaaat
    19861 caaacggatc caactcctca ttacccgcca gcggcgtgcc ttccaccttc accagattgt
    19921 tgatgggcac cgaatccgga tacggctcca tgttcgccag ctcggcgatc aggcccgcac
    19981 gctcgtgcac cgattccccc aggccaacga tgccgccgca gcacacgttg atgcccgcat
    20041 cacgcacatg ctccagcgtg tcgagccgat cctgatacgt acgcgtggtg atgatctcgc
    20101 cgtagaactc cggcgcggta tcgaggttgt ggttgtagta atccagcccc gcgtctttca
    20161 gctgcgcagc ctgctcctgc ttgagcatgc ccagcgtcac gcaggtctcc agccccatcg
    20221 ccttcacacc acgcaccatg tcggccacgg cgtcgagttg atgcggcttc gggttgcgcc
    20281 acgcagcgcc catacagaag cggctcgcac cgttctgctt ggcgcgcgat gcggcttcca
    20341 gcacttcatc aatcggcatc agcttttcag cctccacgcc ggtgtcatag cgcgccgatt
    20401 gcgggcagta cgagcaatcc tccgggcagc cgccggtctt gatcgacagt agcgtcgaga
    20461 gctgcaccgc attcgcatca aagttggcgc ggtgcacctg ctgcgcctgg aacagcaggt
    20521 cattgaacgg cagcgcgaac agcgcttcga tggcttcgcg gctccagcgt gcgtcggggg
    20581 cctggccggg cgtgacgggc accttggcgg cgttcggaac gaagttgagc ggagtaggtt
    20641 gcatgaggac ttccttcaag taatgcgtgg tttctagtta tgcgggtcag gccggcagca
    20701 gccagttcgg cttgcgcttg cccaggaaac tttgcacgcc ttcgcggcct tcttccgagg
    20761 cgcggatggc ggcgatgcgg tctgcggtgt cggccagcag cgcgtcgttg acggcggcgc
    20821 cggacacctc gcgcacgagg cgcttgctct cccgcacggc gttcgggctg ttggcgacga
    20881 gcgcggcagt gatgtcgccc accttggcgt cgagcgtgtc ggcgctcacg agttcatgca
    20941 cgaggcccag gcgatgcgcc tcggcagcag agaagcgctc ggcggtgatg aagtagcggc
    21001 gcgaggcctg ctcgcccagc gcgcggatca cgtacgggct gatggtggcc ggaatcaacc
    21061 cgagcttggc ttccgacagg cagaagttgg cggtatcgac agcgaccacg atgtcgcacg
    21121 cggcgaccag tccaacgcca ccggcatacg tgtcgccttg cacacgcgcg atgacgggct
    21181 tcgggcaggt atagatggcg cgcagcattt cggccaggcg cagggcgtcg gcgcggttct
    21241 cgtcatccga gtagccggcc atcttcttca tccagttcag gtcggcaccg gcgcagaagg
    21301 cggggccgtt gccggccagg acgatggcgc gcacgctggg ctcctgcgcc agcgcacgga
    21361 acgcgcccgt cagctcggcg atgacggtct cgttgaaagc gttgcgcaca tccggccggt
    21421 tgagcgtgag cgtagcaacg gcgccgtgct gcgcgaaggc gagcgtttca aaggcgttca
    21481 ttgggggtcc ttgttggcgc cgctttgcgt gctggcggcg ttgtcaggtg cagcggcggt
    21541 ctgaaccggg ccggcaggca gacccagttc gcgcaggaaa gcgtcgacct cgggtagcca
    21601 gatggacagg cctgcgcggc tggcgaacat gccgtgcgag tcgccctgga agttgccgta
    21661 gtcaaccatg cgtcccttgc cgcccgcttc cgtgtaggcg gcgaacagtc ggtcgggcag
    21721 cggcttgggc cagtagctgt cgttgtcgcc gtagaaccac agcgaggggt agtgtgactg
    21781 cttgccgtag ttgccgaagg cgcgcacgag attgatttcc caggcgacgc agctgtcgtt
    21841 gcgtaggccg cctgcgaagt tgaccagacc gcgcacgccc gggtagtcga tggtgccgaa
    21901 ggccatcgta gtgaggccgc cgtgtgattg gcccatgatg acgatgcgat cacgatcgac
    21961 gtacggttgc ttggtcatgt aatcgagcgt ggcgaccaca tcttcggcct gcacggtgcc
    22021 gttgctctcc acattgcagc cgccaccgat gtaggcgccg cctgacttcg agaagccctg
    22081 gcgcattggc aggacgacca cgtagccgcg cgcgaccagc ggtgcgactt gcgcgctgta
    22141 acgtgcgcgg ctctggaaag ctggattgcc cagcgccttg ccgtggttga gcacgatcag
    22201 cggaaacggc ccgttgccgg ccggcttgaa gatcgtcgtc tcgagcttga cggtgaagat
    22261 gcccacagat ttgggtatct cgatgacctc ctcggtcatg ctgtgggcgg gcttgtcttg
    22321 ggcatgcgca gccgcgagca gcagcgcgca gccaacggct gcccaggcgc tgcgccacgt
    22381 tcgtgcggtc ttgctgttca ctgcagattc cttgttcgat ggccgtccgc ttacatgcgg
    22441 aacacgccga agttcatatc gccaatcggt gcgttcaggc tggccgacag gccgaggccc
    22501 agcacgctgc gcgtatcggc cgggtcgatc acgccgtcat cccacaggcg cgcgctggcg
    22561 taatacgggt ggccttggcg ctcgtactgg tcgcggatcg gcgccttgaa cgcggcttct
    22621 tcatcggcgc tccactggcc gcccttggct tcaatgccgt cgcggcgcac ggtggcgagc
    22681 acgctcgctg cttgttcacc gcccatcacc gagatgcgcg cgttgggcca catccacagg
    22741 aagcgcggcg aatacgcccg cccgcacatg ccgtagttgc ccgcaccaaa cgagccgcca
    22801 atgatgaccg tgaacttggg cacctgtgcc gtcgccactg ccgtcaccat cttcgcgccg
    22861 ttcttggcga tgccttcgtt ctcgtacttg cggcccacca tgaagccggt gatgttctgc
    22921 aggaacacca gcgggatctt gcgctggcag cacagctcga tgaagtgcgc gcccttgagg
    22981 gcagcctctg aaaacagaat gccgttgttg gcgatgatgc cgaccgggta accccagatg
    23041 cgcgcaaaac cacagaccag cgtggtgccg tagcgcgcct tgaattcatc gaaggcggag
    23101 tcgtcgacga tgcgggcgat aacttcgcgc acgtcgaacg gcttgcgcgt gtcggtgggg
    23161 atcacgccat agagttcttc ggcgggaaag cgcggctcaa ccggcgggtg gatctgcacc
    23221 tgctccggct tgcggcggtt caggtgcgcg acgatgctgc gggcctgggc cagcgcgtgc
    23281 gaatcattgt tggcgaagta gtccgccacg cccgacaggc gcgtgtgcac atcggcaccg
    23341 cccaggtctt ccgcgctcac gacttcaccc gtggccgcct tcaccagcgg cgggccggcc
    23401 aggaaaatcg tgccctgttc cttcacgatg atcgactcgt cgctcatggc gggcacatac
    23461 gcaccgcccg ccgtgcacga gcccatcacc actgcgatct gcgggatgcc tttggacgac
    23521 aggttcgcct ggttgtagaa gatgcggccg aagtggtcgc ggtcggggaa gacgtcgtcc
    23581 tggttcggca ggttggcgcc gcccgagtcg accaggtaga cgcagggcag gtggttctgc
    23641 tcggcaatct cctgcgcgcg caggtgcttc ttcacggtca tggggtaata cgtgccgccc
    23701 ttgaccgtgg cgtcgttgca gacgatcacg cattcctgcc ccgagatgcg gccgatgccg
    23761 gtgatgatgc cggcgcccgg cgccgcgtcg tcgtacatgc catacgccgc cagctgcgag
    23821 aactccaaaa acggcgtgcc cgggtcgagc agttgctgca cgcggtcgcg cggcagcagc
    23881 ttgccgcggg cgaggtgctt ggcgcgggcg tcgtcaccgc cgccctgggc gatgcgggcc
    23941 accttgtcgc gcaagtcggc gacgagggtg cgcatggcat cggcgttggc cttgaagtct
    24001 tcggcacggg ggttcagctt ggtgtctagc gtcggcatgg cagcagtgca ggaagtgtgc
    24061 ggtgcggttc agtcagggaa ggtgccgtcg acatagagcc aacggccttc ggcggattca
    24121 gcgccgctgg cgtccaggcg gacgaagcgg ctggtttcat gcaggcgatg cgcgcggccg
    24181 cccaccttgt agcgcgcgac gaattccacc gttgcgtgcg tggcgtcttg cggtacgtgg
    24241 cgtttcacgt ccaggccaag ccagcgtgtg gcggcggcat ctgcctcgct cgtttccaga
    24301 ttggcggggc aggtggacgg atgccacgtg cggcgcagat acgccgtgtc gcccagcaca
    24361 taggcgctgt agcgcgagcg catcaattgc tctgccgtgg ccggcaccgc ttcgcccgca
    24421 tggaacgggc agcagcagcg cgcgtacgca acgccaccgc aggggcaggc gtcggtcggg
    24481 tggatcggct tggcttgggc gctcatcagg ccagcagctc cggcaggtgg cgcatatcgg
    24541 tgaaggtttg cgtagccccc gcggcaagca gcgggccggg cgcgttgcgg ccggcgtagg
    24601 ccagcacggt catgcccgca gcgtggccgg ccgtgacgcc cgtggggctg tcttcaatca
    24661 ccaggcaacg cgacggcgag accccaaggc tgcgggcggc tagcaggtac acatccggcg
    24721 cgggcttgct gcgcgccacc tcggtggccg agaagatgcg cacatcggtc ggttggaagt
    24781 gctcgatcaa gccggtgcgg ttcagttgca gttccacctt cacgcgatcg gcaccggagg
    24841 ccacggccat cggcaggccc agcttggaga gcatatcgat ggcgtgcgca atgtgcggca
    24901 cggcttccac ttcggcttcg agcagcgcat tgcggcgcgc gtggaaggtg gacagccagt
    24961 tcggtggcag cggcgcgccg cgcatttcgg caatcgcatc cagctcttcg cgg
//
