LOCUS       NZ_CP032365.1          11724 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP032365.1 Bacillus wiedmannii strain SR52 chromosome, complete
            genome.
ACCESSION   NZ_CP032365
VERSION     NZ_CP032365.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:17:50
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 979670
            Orig. end    :: 991394
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..390
                     /locus_tag="ctg1_904"
                     /transl_table=11
                     /translation="MAHKSTGVFRVPVSENGIIPTALNIMLNNDSRCHTSNVTVTVKRS
                     RNTSFPTQNELVEISRTFVSLEPNRTTKIVLFTPEFQIEDFLDVIISGNKDDVKDVLVY
                     SFLADSAGHNLPSTVFRNAEYTFAC"
     protocluster    1..11724
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[984434:986627](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4765..6957
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..11724
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11724
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             1258..2376
                     /locus_tag="ctg1_905"
                     /transl_table=11
                     /translation="MIKGIKNIETKEPIKMFLLVPCSILLFDNIYQHFILRKDFSLQKL
                     LFELVFLFIFISFILYNKCLQKMNKQMFTKYIFLGVSIIYLLAYDLMFIRNPDASLHIP
                     YLECFLVISAPLFLSIHYLLWVSICMICRFLIAIYYFDINYPISLVLLFLTIFVTSFFV
                     FLSLKFLVQKIKASYEKQMKETALSIMRIMELKDQYTKGHSERVANYATILAKETNEYD
                     DNSLKQFHFICLLHDIGKIGIPDEVLKKASSLTEEEYNIIKTHPQLGLEVFKNISLIKG
                     SEDIILSHHERWDGKGYPQKLKGNQIPLCARIVAIADAFDAMSRAYRSALSPEEAYRRI
                     IEGSGTQFDPSIVEVFKKVFPLWEKMVPNFFR"
     PFAM_domain     1861..2226
                     /aSDomain="HD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01966.24"
                     /description="HD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_905_0001"
                     /evalue="1.30E-20"
                     /label="ctg1_905"
                     /locus_tag="ctg1_905"
                     /protein_end="323"
                     /protein_start="201"
                     /score="73.9"
                     /tool="antismash"
                     /translation="GHSERVANYATILAKETNEYDDNSLKQFHFICLLHDIGKIGIPDE
                     VLKKASSLTEEEYNIIKTHPQLGLEVFKNISLIKGSEDIILSHHERWDGKGYPQKLKGN
                     QIPLCARIVAIADAFDAM"
     CDS             3044..3325
                     /locus_tag="ctg1_906"
                     /transl_table=11
                     /translation="MFKKLVVGLLATGIALTGGIGAASADTQKAVSSPKQATCSIPYEY
                     SNGKFKRTLYYSNGVYANSFNENVCGGTITWYLKHVQNGVAFYEGNLK"
     CDS             3877..4017
                     /locus_tag="ctg1_907"
                     /transl_table=11
                     /translation="MSNMFHQIGDAIERSMYFKSCFYILTGALLIYIGYIVGKWVGSVV
                     F"
     CDS             4152..4358
                     /locus_tag="ctg1_908"
                     /transl_table=11
                     /translation="MNSVLKKEMPNLAVLSNEELKNIDGGVVPLAIAGVAGFTKVAGAI
                     TAGAGVVGAGYVGGKWVGKKIFK"
     aSDomain        4191..4340
                     /aSDomain="TIGR03949"
                     /aSTool="tigrfam"
                     /description="bact_IIb_cerein: class IIb bacteriocin,
                     lactobin A/cerein 7B family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_908_0001"
                     /evalue="2.30E-07"
                     /identifier="TIGR03949"
                     /label="ctg1_908"
                     /locus_tag="ctg1_908"
                     /protein_end="63"
                     /protein_start="13"
                     /score="28.5"
                     /tool="antismash"
                     /translation="VLSNEELKNIDGGVVPLAIAGVAGFTKVAGAITAGAGVVGAGYVG
                     GKWVG"
     CDS             4381..4557
                     /locus_tag="ctg1_909"
                     /transl_table=11
                     /translation="MKTITLEKYKSLTEEELYDTNGGLGPVIVAGGLLVVGAGAGLWDA
                     YEESQAKKKKKKK"
     aSDomain        4405..4518
                     /aSDomain="TIGR03949"
                     /aSTool="tigrfam"
                     /description="bact_IIb_cerein: class IIb bacteriocin,
                     lactobin A/cerein 7B family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_909_0002"
                     /evalue="2.70E-10"
                     /identifier="TIGR03949"
                     /label="ctg1_909"
                     /locus_tag="ctg1_909"
                     /protein_end="46"
                     /protein_start="8"
                     /score="37.8"
                     /tool="antismash"
                     /translation="YKSLTEEELYDTNGGLGPVIVAGGLLVVGAGAGLWDAY"
     CDS             4765..6957
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 289.7; E-value:
                     7.9e-88)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_910"
                     /sec_met_domain="TIGR01193 (E-value: 1.4e-212, bitscore:
                     706.3, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 9.4e-41, bitscore:
                     137.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLFKKYHWVRQHDIKDCGAACISTVSKHYGLHIPISKIREYAGT
                     DRNGTNVYGLIQAAEKLGFSAKGVRGNVESLKEIPLPAIAHVIIDGKLLHYVVILEITK
                     KGKVIVADPGEGIIKYDIKEFNEIWTGVLVLLIPNESFQSRDEEKNTFSRFMFLLKNQQ
                     SLLIPIFLSSILITIFGVLGAFYFKIVIDNIVTENLKHTLTYLSIGIIVLYIFKVLLEL
                     FRSHLILYLSRRLDIKLMFGYYKHVLSLPMNFFETRKVGEIISRFQDAAKIREALATTT
                     LTVMIDTIMVIAGSILLYTQSSTLFFITALHVPIYILIIWMFQSSYEKINRQEMESNAE
                     LTSYIVESLNGISTIKSYNAEKEAEFQTEKRLISLLQKFFKRFLITNSQESIKTIVELV
                     GGVVILWVGAIAILNGEMTIGQLVAYNALLVYFLDPIKNLVDLQPTLQSAFVASKRLTE
                     ILDLDLEKNDQEDKKLSPTSFHHKIRLDNITFKYGTRQNIFNNLSFEIPIGYSVGFVGE
                     SGSGKTTIAKLLMRYYDVNEGNIYYDNYHIKDMNRTGLRNKIAYVAQESFFFSGSIFDN
                     LVFGLNREVTMDKIIEACILADAHEFISSLPLRYDTLLEENASNVSGGQRQRLSIARAL
                     LKEADVLILDEATSHLDSTSERKIIENLKEYRAGKLTTITIAHRLSTIMHCDNIFVMSK
                     GEIVEEGKHGELINKDGLYRVLWNNQLPQELLEITR"
     PFAM_domain     4780..5184
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_910_0002"
                     /evalue="3.30E-40"
                     /label="ctg1_910"
                     /locus_tag="ctg1_910"
                     /protein_end="140"
                     /protein_start="5"
                     /score="137.1"
                     /tool="antismash"
                     /translation="KYHWVRQHDIKDCGAACISTVSKHYGLHIPISKIREYAGTDRNGT
                     NVYGLIQAAEKLGFSAKGVRGNVESLKEIPLPAIAHVIIDGKLLHYVVILEITKKGKVI
                     VADPGEGIIKYDIKEFNEIWTGVLVLLIPNE"
     aSDomain        4798..6918
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_910_0003"
                     /evalue="1.10E-212"
                     /identifier="TIGR01193"
                     /label="ctg1_910"
                     /locus_tag="ctg1_910"
                     /protein_end="718"
                     /protein_start="11"
                     /score="706.3"
                     /tool="antismash"
                     /translation="QHDIKDCGAACISTVSKHYGLHIPISKIREYAGTDRNGTNVYGLI
                     QAAEKLGFSAKGVRGNVESLKEIPLPAIAHVIIDGKLLHYVVILEITKKGKVIVADPGE
                     GIIKYDIKEFNEIWTGVLVLLIPNESFQSRDEEKNTFSRFMFLLKNQQSLLIPIFLSSI
                     LITIFGVLGAFYFKIVIDNIVTENLKHTLTYLSIGIIVLYIFKVLLELFRSHLILYLSR
                     RLDIKLMFGYYKHVLSLPMNFFETRKVGEIISRFQDAAKIREALATTTLTVMIDTIMVI
                     AGSILLYTQSSTLFFITALHVPIYILIIWMFQSSYEKINRQEMESNAELTSYIVESLNG
                     ISTIKSYNAEKEAEFQTEKRLISLLQKFFKRFLITNSQESIKTIVELVGGVVILWVGAI
                     AILNGEMTIGQLVAYNALLVYFLDPIKNLVDLQPTLQSAFVASKRLTEILDLDLEKNDQ
                     EDKKLSPTSFHHKIRLDNITFKYGTRQNIFNNLSFEIPIGYSVGFVGESGSGKTTIAKL
                     LMRYYDVNEGNIYYDNYHIKDMNRTGLRNKIAYVAQESFFFSGSIFDNLVFGLNREVTM
                     DKIIEACILADAHEFISSLPLRYDTLLEENASNVSGGQRQRLSIARALLKEADVLILDE
                     ATSHLDSTSERKIIENLKEYRAGKLTTITIAHRLSTIMHCDNIFVMSKGEIVEEGKHGE
                     LINKDGLYRVLWN"
     PFAM_domain     5266..6069
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_910_0003"
                     /evalue="1.20E-48"
                     /label="ctg1_910"
                     /locus_tag="ctg1_910"
                     /protein_end="435"
                     /protein_start="167"
                     /score="166.3"
                     /tool="antismash"
                     /translation="PIFLSSILITIFGVLGAFYFKIVIDNIVTENLKHTLTYLSIGIIV
                     LYIFKVLLELFRSHLILYLSRRLDIKLMFGYYKHVLSLPMNFFETRKVGEIISRFQDAA
                     KIREALATTTLTVMIDTIMVIAGSILLYTQSSTLFFITALHVPIYILIIWMFQSSYEKI
                     NRQEMESNAELTSYIVESLNGISTIKSYNAEKEAEFQTEKRLISLLQKFFKRFLITNSQ
                     ESIKTIVELVGGVVILWVGAIAILNGEMTIGQLVAYNALLVYFLDP"
     PFAM_domain     6262..6711
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_910_0004"
                     /evalue="3.40E-31"
                     /label="ctg1_910"
                     /locus_tag="ctg1_910"
                     /protein_end="649"
                     /protein_start="499"
                     /score="108.7"
                     /tool="antismash"
                     /translation="NNLSFEIPIGYSVGFVGESGSGKTTIAKLLMRYYDVNEGNIYYDN
                     YHIKDMNRTGLRNKIAYVAQESFFFSGSIFDNLVFGLNREVTMDKIIEACILADAHEFI
                     SSLPLRYDTLLEENASNVSGGQRQRLSIARALLKEADVLILDEATS"
     CDS             6985..8352
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 84.4; E-value:
                     1.2e-25)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_911"
                     /transl_table=11
                     /translation="MSQPIRDITELTDSVEMLEKNPPKFIKLFIYLVLAIIVSALIWSY
                     FSKIDISTKGSATIQSSTAAVAVKPKVSGEINDIKIKQGEKVHRGDPLIGITNKQLEQE
                     KKHLEENRDKLDAEIKDLNILKDVIEKNQSKLPVDVEGSIKNELDSYLKQKDLLNNENK
                     NKIADFNFRLQGLNHVKDEVINNLEFEIEAIKNQNNILKIEKEGLLKQNKIIKDENINQ
                     ETEANMNKVNQLDSEIEGNLKSILIKQEQIKNRTQEIALEKKVINENIRTQESNIQDSV
                     ESLRTSKVSDISKEIDEKKKQLSLLQQDINNMNLSYEQTVIIAPKDGVIEMPNRIKVGD
                     TIEQDKEVLSISPDENTNRVLLYINSEEINKIKSGDKIKYTFEVGTTETYYGNVVQIYH
                     DPIISKNKDTTFFVVEGTIENKGKKKLRSGSTGKAAIVVDQRNILSLILEKLDILN"
     PFAM_domain     7180..7317
                     /aSDomain="Biotin_lipoyl_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13533.8"
                     /description="Biotin-lipoyl like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_911_0005"
                     /evalue="1.10E-06"
                     /label="ctg1_911"
                     /locus_tag="ctg1_911"
                     /protein_end="111"
                     /protein_start="65"
                     /score="28.4"
                     /tool="antismash"
                     /translation="VAVKPKVSGEINDIKIKQGEKVHRGDPLIGITNKQLEQEKKHLEE
                     N"
     PFAM_domain     7945..8271
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_911_0006"
                     /evalue="2.70E-10"
                     /label="ctg1_911"
                     /locus_tag="ctg1_911"
                     /protein_end="429"
                     /protein_start="320"
                     /score="41.0"
                     /tool="antismash"
                     /translation="VIIAPKDGVIEMPNRIKVGDTIEQDKEVLSISPDENTNRVLLYIN
                     SEEINKIKSGDKIKYTFEVGTTETYYGNVVQIYHDPIISKNKDTTFFVVEGTIENKGKK
                     KLRSG"
     CDS             8390..8533
                     /locus_tag="ctg1_912"
                     /transl_table=11
                     /translation="MFIVSTAVFLLVTLLCITLYFKTHDKRFMYLGYVSLFLTFFVIGT
                     FS"
     CDS             complement(8725..8931)
                     /locus_tag="ctg1_913"
                     /transl_table=11
                     /translation="MKNKRCDNCDSTNFKEGRIGSAYHAYVYEDAPSRFFSGGKNSKLL
                     TTFCLECGEVKSFRVEKPDKFKE"
     CDS             9229..10965
                     /locus_tag="ctg1_914"
                     /transl_table=11
                     /translation="MYTKLLKSITSLTLIGGALLYTNGSDVKAAEAGIFSDVPTSHWSY
                     PAIKDLASKNIISGYGNGKFGFGDVATREQVAALVYRVMLPNKQGGTFSNNNTLYILKD
                     GSKFNNPYGDINQNSTMFPEEILMLTNAGVFKGDEKGNFRPKAPVNRAEMAQILTNAFH
                     LSAKQKHTFNDVPNGFWGENAISAVQSTGIVSGTGEGKFEPSKTVTREQYAQFLYNTLK
                     YKKPEVAVQDTGDAALLAAFKDEVQKRINAYETNITLPYKTKNSNQEEVMKTLFNAYKE
                     VASKNEYTNYNRSNVSYGISGSPGNYTFTLKITYRETKEQTEYVMKQAKAIVSSITQVG
                     MDDHEKVKAIHDYVVKHISYDTSYKAYTAYEALVNRSAVCQGYALLTYQLLKEAGIENH
                     FVVGTGDGQPHAWNLVKIENKWYHLDTTFDDPVTDEQGRVTYSYFNLSDEQIARNHEWN
                     RGDYPQATTNYYSTLTNKIAAGGTKIPAYQQILKDTKLNYLGNEYIVNNYNEFKNKMQQ
                     RYNEKSPKIEILYKQSMDGALQDVKKVIGEIGYPQGANRVSYKAEPYNAKEGYSLVTIT
                     FM"
     PFAM_domain     9331..9459
                     /aSDomain="SLH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00395.22"
                     /description="S-layer homology domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_914_0007"
                     /evalue="1.60E-10"
                     /label="ctg1_914"
                     /locus_tag="ctg1_914"
                     /protein_end="77"
                     /protein_start="34"
                     /score="40.9"
                     /tool="antismash"
                     /translation="FSDVPTSHWSYPAIKDLASKNIISGYGNGKFGFGDVATREQVA"
     PFAM_domain     9559..9693
                     /aSDomain="SLH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00395.22"
                     /description="S-layer homology domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_914_0008"
                     /evalue="4.80E-10"
                     /label="ctg1_914"
                     /locus_tag="ctg1_914"
                     /protein_end="155"
                     /protein_start="110"
                     /score="39.4"
                     /tool="antismash"
                     /translation="PYGDINQNSTMFPEEILMLTNAGVFKGDEKGNFRPKAPVNRAEMA
                     "
     PFAM_domain     9739..9870
                     /aSDomain="SLH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00395.22"
                     /description="S-layer homology domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_914_0009"
                     /evalue="5.00E-10"
                     /label="ctg1_914"
                     /locus_tag="ctg1_914"
                     /protein_end="214"
                     /protein_start="170"
                     /score="39.3"
                     /tool="antismash"
                     /translation="TFNDVPNGFWGENAISAVQSTGIVSGTGEGKFEPSKTVTREQYA"
     PFAM_domain     10219..10503
                     /aSDomain="Transglut_core"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01841.21"
                     /description="Transglutaminase-like superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_914_0010"
                     /evalue="1.10E-13"
                     /label="ctg1_914"
                     /locus_tag="ctg1_914"
                     /protein_end="425"
                     /protein_start="330"
                     /score="51.7"
                     /tool="antismash"
                     /translation="AIVSSITQVGMDDHEKVKAIHDYVVKHISYDTSYKAYTAYEALVN
                     RSAVCQGYALLTYQLLKEAGIENHFVVGTGDGQPHAWNLVKIENKWYHLD"
     CDS             11092..11724
                     /locus_tag="ctg1_915"
                     /transl_table=11
                     /translation="MNKKKILAALIGIIVLLVIINVVIAKGKTTSTSEKMYTEKEYNKL
                     VDEHYEEMQKLKSDMSVLETEKKSLDAQVKKLKDELAKKEQEVVQQPVQQEQPKQQPAP
                     APQPETKEEPKPEQPTGAFANPVKSINKADAMNKVKEKAKQDFQDDYMTQNFVTDEQSK
                     AFDFLNSIEIKSQEELNVMKNALKDFPNDFMTAKFVYEEQMKAKNKQ"
ORIGIN
        1 atggctcata aatctactgg agtgtttcga gttccagttt ctgaaaatgg gattattcca
       61 actgctctca acattatgtt aaacaatgat tcacgctgcc atactagtaa tgtaacggta
      121 actgttaaga gaagtcgaaa cacttctttc ccaactcaaa atgaattagt tgaaatctct
      181 cgtacttttg tttctttaga accaaacaga acaactaaga ttgtgttatt tactccagaa
      241 ttccaaatag aagattttct tgatgttatt attagtggaa ataaagatga tgttaaggat
      301 gttcttgtat attctttctt agcagattca gcaggtcaca atctgccatc tactgttttc
      361 agaaatgcag aatacacttt tgcttgctga caccgtgatg atgtattctt tactgttgta
      421 tcaaggtgct atcctgcggc ttgaaccatc ttaattttat cccgctttaa tgggcagtaa
      481 gacccccacc tcaaaattca gcgaaagcaa agaagttagg tgggggatca actgcccata
      541 aaagtccgat tggttcaact aataatcagt gggggatgaa gaaaaccccc actgattaaa
      601 gtttcacttt attgtgttgt tattatataa gaaaagaaga catcgattaa gatgtcttct
      661 ctttgtacac ttggtgttaa gaaggtatta tattgcttaa aaactatgaa aaaatataac
      721 aatcatcgag taagcctatt atagcatcaa taaacaggtt taaatattta atattacata
      781 tatatataga tttatttata tttaatctat atagttaaat tgtctgttat ttgttttaat
      841 tcatttactt attttatttt tgagtgctcc agcaatggag ccttttttta tattggtgag
      901 attgtactaa tatgaaagaa tagaattaac tgtatattgt aagggtgata tacctataga
      961 gtttttgttt gagcttcgaa aagaattggt gaaagccatt gtacgtgaag tttctgcata
     1021 tgttttattt acataaaatt tgttatccgt agtaagaaaa aggcgaattc ctactttcaa
     1081 aaggaattcg cctttttcta taaccctatt cattttttta tacatttcta tcatggcggt
     1141 accccgttta taggttatga gaaagggtgt tttttgcact attttctatt cttggagatt
     1201 attaataata tctatatgaa cttatttttt tattaaaaag gtttggcggt gtgtaaaatg
     1261 attaaaggga ttaaaaatat tgaaacgaaa gagccgataa aaatgtttct attggttccc
     1321 tgtagtattc ttttgtttga taatatttat caacatttta ttcttagaaa ggatttttca
     1381 ctacagaaac ttttatttga actcgtattt ttatttattt ttatttcatt tattttatat
     1441 aataagtgtt tacaaaaaat gaataaacaa atgtttacaa aatatatttt tcttggagta
     1501 agtattattt atcttttggc atatgatctt atgtttatac gtaatccaga tgcttcttta
     1561 catatccctt atttagagtg cttcttagta atttctgcac ctttattttt aagtattcat
     1621 tatcttttat gggtatctat ttgtatgata tgtagatttt taattgccat ttattatttt
     1681 gacattaact atccaatatc attagtatta ttgtttctaa caatttttgt tacgtcattt
     1741 tttgtatttc tttcattaaa atttttagta caaaaaatca aagcatccta tgaaaaacaa
     1801 atgaaagaaa cagctttatc aataatgaga ataatggaat taaaggatca atatacgaaa
     1861 ggacatagtg aacgtgtagc caattatgct actattcttg ctaaagaaac aaatgaatat
     1921 gatgataatt ctttaaaaca atttcatttt atttgtttat tacatgatat agggaaaata
     1981 ggtattccgg atgaagtttt aaagaaagca tcttctctta cagaagaaga atataatatt
     2041 attaagacac acccacaatt aggattagaa gtttttaaaa atatatcttt aataaaaggt
     2101 agtgaagaca taattctttc tcatcatgaa agatgggatg gaaagggcta tcctcaaaaa
     2161 ctaaaaggaa atcaaatacc attatgcgca agaattgttg caatagcaga tgcattcgat
     2221 gcaatgtcaa gagcatatcg ttcggcccta tctcctgaag aagcttatag acgtattata
     2281 gaaggatctg gtacacaatt tgatccttct atagtagagg ttttcaaaaa ggtatttcct
     2341 ttgtgggaaa aaatggttcc aaattttttt cgttaaaagc tcatgtctga aatcgattca
     2401 tatttgaggt atgatgaatg cggaaaatga aaaaaacgaa tccaatcgtg ataaaagttt
     2461 ggaactagat aatgaataag gcacataaag aaaaggtacc tatatatagg taccttttct
     2521 aatagttttt tagcagaaac aactgcatcc gataatgatt aagagaataa ataatacaac
     2581 taataaagca aatcctccag cgaaaccgca gccttcgccg caactaccac catatcccat
     2641 aacaatagtg cctcctttag ataagagggg aaaactaggg ttcattccat agattttaac
     2701 gggttcactt taacttatgt tttaaagaat gaattgagca ggtccttttg aaaataaaga
     2761 aaagacgcca ttaggcgcct tccttttagg tagataagac tttagttttc caatctaaag
     2821 aaattttgta tcagctcttt gtgagtatat cataatatct gattgattta ttatgcattg
     2881 ttacatactt tcctaaactc ctctattttc catttgataa aataaaatcc taatattacc
     2941 aaaaatcaaa taaatatttc tatatattca atatatttac aaaaaataaa aaagtgatac
     3001 atttaagttg taagctataa aaactattaa agggggattt attatgttca agaaattagt
     3061 agtagggcta ttggcaactg gtattgcatt aacaggagga attggagcgg cttcagctga
     3121 tacgcaaaaa gctgtgagct ctccgaagca agcaacatgc tcaattcctt atgagtattc
     3181 taatggtaaa ttcaaaagaa ctctttatta ctcaaatgga gtatatgcta atagttttaa
     3241 tgaaaatgtt tgtggcggga cgattacgtg gtatttaaaa catgttcaaa atggagttgc
     3301 tttttacgaa ggtaatttaa aatagtagat tctttgaacc tcatttattg aggttctttt
     3361 atttttagtt tttaaaatga tgctccataa aaaggcaaaa agaacttgtg gaaatcacta
     3421 caagttctct tttttgttaa agcgagtaca ggggatacat aaattatctc attattcata
     3481 acggggaaac catattgatt acggcttagt tccattatat aacaattttt gattttttga
     3541 agatcatgta aattagattg gtgagaggat acatcattta ataagcctat tattcctcaa
     3601 ctttatagaa agatatgctc aagcgttatc ataagggtta ggggatttat taaatagaaa
     3661 taattagttg taatataacg tgttttttac ctaataaacc ttttgaattc taaatattaa
     3721 ctatagagta attcatttca taaattttaa atttttgtga acgctgttat tattttatat
     3781 ataattatcc caataagtat tgtattgatt agttgttttc tgataacatc gctgtgtgtt
     3841 ctactctaat aattataaaa aggtggtgtt ttctttatgt caaacatgtt tcatcaaatt
     3901 ggtgatgcga ttgaaaggag tatgtatttt aaatcttgtt tttatatctt aacaggagct
     3961 ctgcttattt atattggtta cattgtaggt aagtgggtgg gttctgttgt attctaaagt
     4021 aaaataatgg aatttaatca agaaaaaaga attttttcaa aaaagtgtag atttttatta
     4081 aaaggtgtat taatataaaa tccatattac ttaaatgtaa tataattaaa ttaagaatag
     4141 gagatattat tatgaattca gtattaaaaa aagaaatgcc taatttagca gtattaagta
     4201 atgaggaatt aaaaaacatt gatggtggag tggttccttt agcaattgct ggggttgctg
     4261 gttttacaaa agtagctggt gcaataacag ctggagctgg agttgttgga gcaggttatg
     4321 taggcggaaa atgggttggt aaaaagattt tcaaataaga ggtagtaagg agtgcttaaa
     4381 atgaaaacga ttactttaga aaagtacaaa agtctaactg aagaagagtt gtacgataca
     4441 aatggtggac ttggtcctgt aatagtagca ggtggcttac tagttgttgg agctggtgct
     4501 ggactgtggg atgcttacga agagagtcaa gcaaaaaaga aaaagaagaa aaaataaaca
     4561 tttttataaa gaggaaaaga ttgtatgcgc ttaatagtac aatcttttct tctttataaa
     4621 aagcctttcg atatggaatt tttgaaaggc taacaaattt tattgttatc tttaagtaca
     4681 ataagtttga cactcctgtg tttattaaca tatgtgggag agaatgcatt taaaagttaa
     4741 atatgagagg ttgtttaaat aagtatgtct ttatttaaaa aatatcattg ggtgagacaa
     4801 cacgatatta aagattgtgg tgcagcatgc atttctactg tttctaaaca ttatggatta
     4861 catataccta tctccaaaat cagagaatat gctggaactg atagaaatgg aacgaatgtt
     4921 tatggtttaa ttcaagcggc tgaaaagtta ggtttttctg ccaaaggagt aaggggaaat
     4981 gtagaatctt taaaagagat tccattaccc gctattgcgc atgtcataat tgatgggaag
     5041 ttattacatt atgttgttat tttagaaatc accaaaaagg gtaaagtgat tgttgctgat
     5101 cctggagaag ggattattaa atatgatatt aaggaattta atgagatttg gacaggcgtt
     5161 ttagttcttt taatacctaa tgaatctttt caatcaagag atgaagagaa aaatacattc
     5221 agtagattta tgtttctttt aaaaaatcaa caaagtctct taattcctat ttttctttca
     5281 tcaattttaa taaccatatt tggagttttg ggtgcttttt atttcaaaat tgtaattgat
     5341 aatattgtta ctgagaattt aaagcatacg ctaacatatc tttctattgg gatcatcgta
     5401 ttatacattt ttaaagttct tttagagttg tttaggtcgc atttaatttt atatttgagt
     5461 cgtcggttag atataaagtt aatgtttggt tactataaac atgttttatc cttacctatg
     5521 aacttttttg aaacaagaaa agttggtgaa attatttcga ggttccaaga tgctgctaaa
     5581 attagggagg cacttgcgac aacaacttta actgtgatga ttgatacgat catggtaata
     5641 gctggttcta ttttgttgta tacacaaagt tctactttat ttttcattac agcattacac
     5701 gtacctatat acatccttat tatttggatg tttcaaagct cttatgaaaa aattaatcgt
     5761 caagaaatgg aaagtaatgc tgaattaact tcttatattg tagaatcgct aaatgggata
     5821 tcaacaataa aatcctataa tgctgaaaaa gaagcagaat ttcaaactga aaaaagattg
     5881 ataagtcttt tgcagaaatt ctttaaacgg tttttaatta caaatagtca agaatctatt
     5941 aaaacaattg tggaattagt aggaggtgtt gtaattttat gggttggagc tattgctata
     6001 ttaaacgggg aaatgacaat aggtcagcta gttgcatata atgcactatt agtgtatttc
     6061 ttagatccta taaaaaacct agtagattta cagccaacat tacaatctgc ttttgttgct
     6121 tcaaaaagat tgactgagat tttagattta gatttagaaa aaaatgatca agaagataaa
     6181 aaactttcac ctacttcttt tcatcacaaa attagattgg ataatataac ttttaaatat
     6241 ggaactaggc aaaatatatt taataattta agttttgaaa tcccaattgg atatagtgtt
     6301 gggtttgtag gggaaagtgg ttcaggtaaa acaacaattg ctaaattatt aatgagatat
     6361 tatgacgtaa acgaaggtaa catttattat gataactatc atattaaaga tatgaatagg
     6421 acaggtttaa gaaataaaat agcttatgtt gctcaggaat cttttttctt tagtggtagt
     6481 atttttgaca atttggtatt tggtttgaac agagaggtaa caatggacaa aataatagag
     6541 gcatgtatat tggccgatgc ccatgaattc attagttcct tgccactccg atatgacaca
     6601 ttattagaag aaaatgcttc taatgtatct ggtggtcaac ggcaacggtt atcaattgcc
     6661 cgtgctctat taaaagaagc agatgtactt attttagatg aggctacaag tcatctggat
     6721 tcgactagtg agagaaaaat aattgaaaac ttaaaggaat atagagcagg taaactaaca
     6781 accataacaa ttgctcatcg attaagtaca attatgcatt gtgataacat atttgtaatg
     6841 agcaaaggag aaattgttga ggaaggcaag catggagaat taataaataa agatggttta
     6901 tatagagtgt tgtggaataa tcagctacca caagaattat tagagatcac ccgataaaaa
     6961 ggagcataag aggagtatac ataaatgtca caaccaataa gagacataac agagctgact
     7021 gatagcgttg aaatgcttga gaaaaatccc ccgaaattta ttaagctatt tatctatcta
     7081 gtactagcta taatagttag tgctttgatt tggtcttatt ttagtaaaat agatatctca
     7141 actaaagggt ctgctactat ccaatcttct acggctgcag tagctgttaa accaaaagta
     7201 tcaggagaaa ttaatgatat taagattaaa caaggcgaaa aagtacatag gggagatcct
     7261 ttaataggta taactaataa acagttagag caggaaaaaa aacacttaga agaaaataga
     7321 gataaattgg atgcggaaat taaggattta aacattctta aagatgttat tgaaaagaac
     7381 caatcaaaat tgcctgtaga tgttgaagga agtattaaaa atgaattaga tagctattta
     7441 aagcaaaaag acttattaaa taatgaaaat aaaaataaga ttgctgattt taactttcgc
     7501 cttcaaggcc taaatcatgt aaaagatgag gttataaata atctggaatt tgaaattgaa
     7561 gctataaaaa atcaaaataa tatcttaaaa attgaaaaag aggggcttct taaacaaaat
     7621 aagattatta aggatgaaaa tattaatcaa gaaactgaag caaatatgaa taaggttaat
     7681 caattagatt ctgagattga ggggaatcta aagagtattt taataaaaca agagcaaata
     7741 aaaaatagga cccaggaaat agcattggag aaaaaggtta tcaatgagaa tataagaact
     7801 caagagtcta atatccaaga ttctgttgaa agtcttagaa cttctaaagt ctcagatatt
     7861 tcgaaggaga ttgatgaaaa gaaaaaacaa ttgtctttgt tgcaacaaga tatcaataat
     7921 atgaatttga gttatgaaca aactgtaatt attgcaccga aagatggtgt aattgaaatg
     7981 ccgaatcgta ttaaagtagg ggacacgatt gaacaagata aagaggtatt atcaatatca
     8041 cctgatgaaa atacgaatag ggtattatta tatattaatt cagaagagat taataaaatt
     8101 aaatcgggcg ataaaattaa atatactttt gaagtgggaa cgacggaaac ttattatgga
     8161 aatgtagttc aaatctatca tgatcctatt attagcaaga ataaagatac tacattcttt
     8221 gttgtagaag gaacaattga aaataaaggg aaaaagaagt tgcgatcagg ttctactgga
     8281 aaagctgcaa ttgtagtaga tcaaagaaat attctttcat taatattaga aaaattagat
     8341 atacttaact gacaaagaat aataaattag ctttttagga ggaacattca tgttcatagt
     8401 gtctacagca gtttttttac tggtcacttt actgtgtatt acgttatatt ttaaaacaca
     8461 cgataaacgt tttatgtatc ttggatatgt atcattattt ttaacttttt ttgttattgg
     8521 tactttttca taattaaatg tcagtggttt atcacaaact aaattaagaa gagcatatat
     8581 aagagagaaa aggcattcat aagaatgcct tttctttatc aattaagttt atctgaatca
     8641 tttttagata atattctttt tctattagct caaatataaa gaatgctatt ttcatgttag
     8701 taacaacatc ttctggaata cattttattc tttgaattta tccggttttt caactctgaa
     8761 tgatttgacc tcaccgcatt ctaaacagaa tgtggttaat agtttggaat ttttccctcc
     8821 tgaaaagaac ctactcggtg catcctcata aacatacgca tgataagcgc ttccaattcg
     8881 cccctcttta aaattagtag aatcgcaatt atcacatctt ttatttttca tgttactaac
     8941 acctctttag gttgatattt atattggcgt attctctatc tcctttacaa tagaagtaaa
     9001 gcaacttggt tataaatgat gttttcgaca taagacacca tagcccttta tatattcgca
     9061 agtaaaacaa cataatatca ctatgaattt ttataacaat atgagttttt gcatatttca
     9121 aaacttaata tatccttcaa aaaattttaa tagtataata tgttttgtca tattctttta
     9181 gatttttcga caaaatataa aatagagaac gtattgggag aaggaattat gtacacaaaa
     9241 ctattaaaat caattacatc attaacactt attggtggcg ctttattata tacgaatggc
     9301 agtgatgtga aagctgctga ggcgggtatt ttttctgatg tgcctacatc gcattggtcg
     9361 tatcccgcga ttaaagattt agcgagtaaa aatattattt ccggttatgg aaatggaaag
     9421 tttggttttg gagatgttgc gacgagggag caagtagctg ctttagtgta tcgagttatg
     9481 ctaccgaata aacaaggcgg aacgtttagt aataataata ctctttacat attaaaagac
     9541 ggatctaagt ttaataatcc ttatggtgat attaatcaga actctacgat gtttcctgag
     9601 gaaattttaa tgttaacgaa tgcaggggta tttaaagggg atgagaaagg gaattttaga
     9661 ccgaaagctc ctgtgaatcg cgcagaaatg gcacaaattc ttacaaacgc tttccatctt
     9721 tctgcgaaac aaaagcatac atttaatgat gttccaaatg gtttttgggg tgaaaacgct
     9781 attagcgcag tgcagtcaac cggaattgtt tctggtacag gcgaaggaaa atttgagcca
     9841 tctaaaacgg taacacgtga acagtatgca cagtttttat ataatacttt gaaatataaa
     9901 aagcctgaag ttgcggtgca agatacaggg gatgcggcat tattagcagc atttaaagat
     9961 gaagtgcaaa agcgtattaa tgcgtacgaa acgaatatta cacttccata taaaacgaaa
    10021 aatagtaatc aggaagaagt aatgaagaca cttttcaacg cctataaaga agtcgcaagt
    10081 aaaaatgagt atacaaatta taatagatcg aatgtttcat atggcatttc tggatcacct
    10141 ggaaattata cgtttacgtt aaagattaca tatcgtgaaa cgaaagaaca aacggaatat
    10201 gtaatgaagc aagcaaaggc gatcgtttct tctattacgc aagtaggaat ggatgatcat
    10261 gaaaaagtga aggcaattca tgattatgtc gtaaagcata tttcttacga tacgtcttat
    10321 aaagcttata cagcatatga agcactcgta aatcgttctg cggtttgcca aggttacgca
    10381 ctattaacct atcaattatt aaaagaagct ggaattgaga atcattttgt agtaggaact
    10441 ggagacggtc agcctcacgc ttggaacttg gtgaaaatcg aaaacaaatg gtatcacctt
    10501 gatacaacat tcgatgatcc ggtgacagat gaacaaggtc gcgtaacgta ttcttatttc
    10561 aacttatctg acgagcaaat tgcaagaaat catgagtgga accgcgggga ctatccgcaa
    10621 gctacaacaa attattatag tacattaaca aataaaattg cggcaggtgg tacgaaaatc
    10681 cctgcatatc agcaaatatt aaaagataca aagttaaatt atttaggaaa tgaatacatc
    10741 gtaaataact ataatgagtt caaaaataaa atgcagcaac gttataacga aaagtcacca
    10801 aagatcgaaa tcctttataa acaatcaatg gatggcgcat tgcaagatgt gaaaaaagta
    10861 attggagaaa tcggttatcc gcaaggggcg aaccgtgttt cttataaagc tgagccgtat
    10921 aatgcaaaag aaggatattc tttagtgacg attacgttta tgtagtgaga atgggaaaaa
    10981 gcatctgttt tagatgcttt tttattattt tagttcgaca aaatatgaca aaggaacata
    11041 gctgcatctg ttatgataac tttggtaatt ttacattttg gaggattaat aatgaacaaa
    11101 aagaagattt tagctgcgtt aataggaatc atagtgttac ttgtaattat taatgtagtt
    11161 attgcgaagg gaaaaacgac atcaactagt gaaaaaatgt acactgagaa agaatacaat
    11221 aaattagtag atgaacatta tgaagaaatg caaaagttaa aaagtgatat gagtgtatta
    11281 gaaactgaaa aaaaatctct tgatgcgcaa gttaagaagt taaaagatga attagcgaaa
    11341 aaagagcaag aagtagtaca acagccagtt caacaagaac aacctaagca acaaccagcc
    11401 ccagctccac agccggaaac gaaagaagag ccgaaaccag aacagcctac aggcgcattc
    11461 gcaaaccctg tgaaaagtat aaataaagca gatgcaatga acaaagtgaa agaaaaagcg
    11521 aagcaagact tccaagatga ctatatgacg caaaactttg ttacggatga acaatcaaaa
    11581 gcatttgatt tcttaaatag cattgaaatt aaatcacaag aagaattgaa cgtgatgaag
    11641 aatgcattaa aagattttcc taacgatttt atgaccgcga agtttgttta cgaagaacaa
    11701 atgaaggcga agaataagca atga
//
