LOCUS       NZ_CP016786.1          12280 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP016786.1 Clostridium isatidis strain DSM 15098 chromosome,
            complete genome.
ACCESSION   NZ_CP016786
VERSION     NZ_CP016786.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:51:34
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 305343
            Orig. end    :: 317623
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12280
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[310343:312623](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7280
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12280
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12280
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             93..944
                     /locus_tag="ctg1_282"
                     /transl_table=11
                     /translation="MKNGFNKFIKLIKGKDKNIEKGSDNMKNKMPVIFIGHGSPLNMIL
                     DNDYTRDLSEFGKSLERPKAILVISAHFYTKGSYITYSDKPKQIYDFYGFPDEMYKMEY
                     RPDGGKEYALKTYELLKDFGVKLTEDWGLDHGSWGILHFLFPKADVPTFQLSINADLTE
                     EEHYNMAKKLLKLREEGVLIIGSGNISHNLRVMEYEMDAKPLEFALEFDEYIKKSLLEG
                     NHENVINYKKLGEIASLAVPTPDHYLPLIYTIALQEEGEKIDFIHENIQNGSMAMRSFI
                     IN"
     PFAM_domain     243..929
                     /aSDomain="LigB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02900.20"
                     /description="Catalytic LigB subunit of aromatic
                     ring-opening dioxygenase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_282_0001"
                     /evalue="1.70E-30"
                     /label="ctg1_282"
                     /locus_tag="ctg1_282"
                     /protein_end="279"
                     /protein_start="50"
                     /score="106.2"
                     /tool="antismash"
                     /translation="RDLSEFGKSLERPKAILVISAHFYTKGSYITYSDKPKQIYDFYGF
                     PDEMYKMEYRPDGGKEYALKTYELLKDFGVKLTEDWGLDHGSWGILHFLFPKADVPTFQ
                     LSINADLTEEEHYNMAKKLLKLREEGVLIIGSGNISHNLRVMEYEMDAKPLEFALEFDE
                     YIKKSLLEGNHENVINYKKLGEIASLAVPTPDHYLPLIYTIALQEEGEKIDFIHENIQN
                     GSMAMRS"
     CDS             1108..2055
                     /locus_tag="ctg1_283"
                     /transl_table=11
                     /translation="LKIKSFLKLVEIQTKAASVIPYFLASLFVYYRYNIFNFKNAIIMF
                     FSMLIFDMTTTAINNYIDYAKAIKKEGFGYESHNAIVRDKLNPDHVRYLIYAMLGTAAL
                     LGLLLVANTNIVVLLLGALAFVIGITYTFGPIPISRTPFGELFSGLAMGFLLTFITMYI
                     HIFDRGILNIDYTNFNSINIVFNLKELVILFIVCLPAITGIANIMLANNICDIEDDIVN
                     KRYTLPIYIGKENALKLFKWLYYIGYMAIVIAVVIRVLPLYSLLSVLVLKKVKENIDKF
                     NELQTKKDTFGLAVENFALTNIVLAITILVGVII"
     PFAM_domain     1162..1917
                     /aSDomain="UbiA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01040.20"
                     /description="UbiA prenyltransferase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_283_0002"
                     /evalue="5.50E-21"
                     /label="ctg1_283"
                     /locus_tag="ctg1_283"
                     /protein_end="270"
                     /protein_start="18"
                     /score="75.1"
                     /tool="antismash"
                     /translation="VIPYFLASLFVYYRYNIFNFKNAIIMFFSMLIFDMTTTAINNYID
                     YAKAIKKEGFGYESHNAIVRDKLNPDHVRYLIYAMLGTAALLGLLLVANTNIVVLLLGA
                     LAFVIGITYTFGPIPISRTPFGELFSGLAMGFLLTFITMYIHIFDRGILNIDYTNFNSI
                     NIVFNLKELVILFIVCLPAITGIANIMLANNICDIEDDIVNKRYTLPIYIGKENALKLF
                     KWLYYIGYMAIVIAVVIRVLPLYSLLSVLV"
     PFAM_domain     2055..2270
                     /aSDomain="GIY-YIG"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01541.26"
                     /description="GIY-YIG catalytic domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_284_0003"
                     /evalue="2.10E-20"
                     /label="ctg1_284"
                     /locus_tag="ctg1_284"
                     /protein_end="72"
                     /protein_start="0"
                     /score="72.8"
                     /tool="antismash"
                     /translation="MNYVYMLECSDGSLYTGWTNNLEKRIAAHNNGKGAKYTRVRLPVK
                     LVYYEEYEDKIEAMKREYEIKQLSRKE"
     CDS             2055..2297
                     /locus_tag="ctg1_284"
                     /transl_table=11
                     /translation="MNYVYMLECSDGSLYTGWTNNLEKRIAAHNNGKGAKYTRVRLPVK
                     LVYYEEYEDKIEAMKREYEIKQLSRKEKVKLIKFQ"
     CDS             2506..3219
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 61.5; E-value: 1.5e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_285"
                     /transl_table=11
                     /translation="MNILLVEDDTLQSSILRKIIEKNYIDIRVYEAKSEKEAMYIIEKE
                     EIDLFFIEMNIKQKSGLTLAENIRKIEKYELTPIVFISKEIDYIITAFKKVNCYDFLTK
                     PISVNNIKKIIDKFLRHKNKITNESYNFFKTIDGNDVRVYTKDIIFIEFYLKSCILHTL
                     HGEYKIKSDGLNKILDKINNDNIIRTHKSFAVNLEHIKEIRKVNFKLWEISFYNYDKTS
                     ELSYSYRKYIKNIIK"
     PFAM_domain     2512..2850
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_285_0004"
                     /evalue="2.40E-17"
                     /label="ctg1_285"
                     /locus_tag="ctg1_285"
                     /protein_end="115"
                     /protein_start="2"
                     /score="63.2"
                     /tool="antismash"
                     /translation="ILLVEDDTLQSSILRKIIEKNYIDIRVYEAKSEKEAMYIIEKEEI
                     DLFFIEMNIKQKSGLTLAENIRKIEKYELTPIVFISKEIDYIITAFKKVNCYDFLTKPI
                     SVNNIKKII"
     PFAM_domain     2929..3213
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_285_0005"
                     /evalue="1.00E-13"
                     /label="ctg1_285"
                     /locus_tag="ctg1_285"
                     /protein_end="236"
                     /protein_start="141"
                     /score="51.4"
                     /tool="antismash"
                     /translation="RVYTKDIIFIEFYLKSCILHTLHGEYKIKSDGLNKILDKINNDNI
                     IRTHKSFAVNLEHIKEIRKVNFKLWEISFYNYDKTSELSYSYRKYIKNII"
     CDS             3587..3976
                     /locus_tag="ctg1_286"
                     /transl_table=11
                     /translation="MSAFVLSREYELQLPISYVDIDRAEMEYVDGGYSIPVNVAMLSSA
                     YCLSYATTLWIQGVISFSNILVIAKEIRGHAAAYYGLSGLSALGISNSTLEEMKRSANP
                     IDIRDGYDPRWYVVAACELIWTLPG"
     CDS             4000..4698
                     /locus_tag="ctg1_287"
                     /transl_table=11
                     /translation="VKKIILGISILFISIISIMLLIAVKEQRDIVARYITDEHYRYKPV
                     EMKDEVYFPSTVDLGNENGLKEIGYLSVKNKSIVNDLLLIVGKVLVDESDKNYTHFSVI
                     DDFAMNYTKGEYLQDKSIINYTMNKYNDFVLCNDKNDLETRITLEKDVLYMLQDEFKTI
                     EYKADDFKNSDDRYYIYVNSPQKKLHGRTFDDPIIFMGCILVKDNKLYYGNFDNEIKGE
                     LLNKIILYIK"
     CDS             5001..7280
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 283.7; E-value:
                     5.2e-86)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_288"
                     /sec_met_domain="TIGR01193 (E-value: 2.3e-187, bitscore:
                     621.9, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.6e-37, bitscore:
                     123.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNKYLVKQHDITDCAAASLATICMYYKKEITITKLRDILGTDIK
                     GTTLAGLENGAKKLGFDTKAIRVDKEGFKSKYTLPAIAHVITKEGLTHFVIIHKVKKEE
                     VIILDPAKGKEKVNIDKFFESFDGILLLLVPNKEFNPGKIKGQGILNKFIQLLLPQKSL
                     FIYSIIASVILTILGIASSFFNKILMDEILPYSLKNQLNIFVIGFLVLGITQIGLGAIR
                     QHMLLYLSQKIDIPLLLGYFKHVYKLPMKFFATRKVGDILTRFSDAFTIKNILTSVSLS
                     LLMDIVLAVASASILYVMNQKLFIVILVLTLISAALIYIFKHPYKKINIEQMEAGARLN
                     SQIIESLRGIETIKVNSAEEKSIEKLENEYIRNLRIAFKEGVLSNIQGSISGAVSTMGN
                     LVLMYIGARMIMDGDITLGSLMAFTTLSGYFMDPIGRLISLQLSIQEASISLKRISEIY
                     EVEKEQLEEDFDKVKLEKIDGDIELNNITFRYGSRSPVLKNVSIKIPKGKKVALVGESG
                     SGKTTISKLILKYYTPEEGKININGYNIEELDLYNLRQNISYVPQNVELFSGTIKDNIT
                     LGRPNASYEEIKAACENSGCSEFIERLPGKYGTFLEEAGGGLSGGEKQRLALARALIKK
                     SKFMILDEATSNLDFISEAKVFNTLFKKGKNITMLIIAHRLSTIRNCDIIYVMDKGRVV
                     EVGDHESLLRKKGYYYRLYISQVGSFEEKEIVFNENLNMGTEDVSSKEIKLEEDIIEEG
                     EIYEYN"
     PFAM_domain     5013..5411
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_288_0006"
                     /evalue="5.40E-36"
                     /label="ctg1_288"
                     /locus_tag="ctg1_288"
                     /protein_end="137"
                     /protein_start="4"
                     /score="123.4"
                     /tool="antismash"
                     /translation="YLVKQHDITDCAAASLATICMYYKKEITITKLRDILGTDIKGTTL
                     AGLENGAKKLGFDTKAIRVDKEGFKSKYTLPAIAHVITKEGLTHFVIIHKVKKEEVIIL
                     DPAKGKEKVNIDKFFESFDGILLLLVPNK"
     aSDomain        5025..7139
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_288_0001"
                     /evalue="3.80E-187"
                     /identifier="TIGR01193"
                     /label="ctg1_288"
                     /locus_tag="ctg1_288"
                     /protein_end="713"
                     /protein_start="8"
                     /score="621.9"
                     /tool="antismash"
                     /translation="QHDITDCAAASLATICMYYKKEITITKLRDILGTDIKGTTLAGLE
                     NGAKKLGFDTKAIRVDKEGFKSKYTLPAIAHVITKEGLTHFVIIHKVKKEEVIILDPAK
                     GKEKVNIDKFFESFDGILLLLVPNKEFNPGKIKGQGILNKFIQLLLPQKSLFIYSIIAS
                     VILTILGIASSFFNKILMDEILPYSLKNQLNIFVIGFLVLGITQIGLGAIRQHMLLYLS
                     QKIDIPLLLGYFKHVYKLPMKFFATRKVGDILTRFSDAFTIKNILTSVSLSLLMDIVLA
                     VASASILYVMNQKLFIVILVLTLISAALIYIFKHPYKKINIEQMEAGARLNSQIIESLR
                     GIETIKVNSAEEKSIEKLENEYIRNLRIAFKEGVLSNIQGSISGAVSTMGNLVLMYIGA
                     RMIMDGDITLGSLMAFTTLSGYFMDPIGRLISLQLSIQEASISLKRISEIYEVEKEQLE
                     EDFDKVKLEKIDGDIELNNITFRYGSRSPVLKNVSIKIPKGKKVALVGESGSGKTTISK
                     LILKYYTPEEGKININGYNIEELDLYNLRQNISYVPQNVELFSGTIKDNITLGRPNASY
                     EEIKAACENSGCSEFIERLPGKYGTFLEEAGGGLSGGEKQRLALARALIKKSKFMILDE
                     ATSNLDFISEAKVFNTLFKKGKNITMLIIAHRLSTIRNCDIIYVMDKGRVVEVGDHESL
                     LRKKGYYYRLY"
     PFAM_domain     5490..6299
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_288_0007"
                     /evalue="2.70E-44"
                     /label="ctg1_288"
                     /locus_tag="ctg1_288"
                     /protein_end="433"
                     /protein_start="163"
                     /score="152.0"
                     /tool="antismash"
                     /translation="FIYSIIASVILTILGIASSFFNKILMDEILPYSLKNQLNIFVIGF
                     LVLGITQIGLGAIRQHMLLYLSQKIDIPLLLGYFKHVYKLPMKFFATRKVGDILTRFSD
                     AFTIKNILTSVSLSLLMDIVLAVASASILYVMNQKLFIVILVLTLISAALIYIFKHPYK
                     KINIEQMEAGARLNSQIIESLRGIETIKVNSAEEKSIEKLENEYIRNLRIAFKEGVLSN
                     IQGSISGAVSTMGNLVLMYIGARMIMDGDITLGSLMAFTTLSGYFMDP"
     PFAM_domain     6489..6938
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_288_0008"
                     /evalue="2.50E-34"
                     /label="ctg1_288"
                     /locus_tag="ctg1_288"
                     /protein_end="646"
                     /protein_start="496"
                     /score="118.8"
                     /tool="antismash"
                     /translation="LKNVSIKIPKGKKVALVGESGSGKTTISKLILKYYTPEEGKININ
                     GYNIEELDLYNLRQNISYVPQNVELFSGTIKDNITLGRPNASYEEIKAACENSGCSEFI
                     ERLPGKYGTFLEEAGGGLSGGEKQRLALARALIKKSKFMILDEATS"
     CDS             7267..7764
                     /locus_tag="ctg1_289"
                     /transl_table=11
                     /translation="MSTIEKIIVRENKTLKLNNVLIREVSENELIDIERISYMMDSYIK
                     SKGASTIGPMINYSGIETDENGEAKIKMKLMVQLKNSIYKVEKPYSIKPQIRVTNCLFA
                     RFTEKQENLQYAYQKLGVYAFENDIKLKGDSYTVFVKQEEDNIVADVFMEEAKGGELLE
                     SI"
     CDS             7751..8863
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 66.3; E-value:
                     3.8e-20)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_290"
                     /transl_table=11
                     /translation="LKVYNLNEITDSKVLYDKKPPAFMNYIILIVLALIVAALIWANKS
                     VKTYMVKGQGLVVSENKSHIMTKASGEIKEVFIEEGSEVKEGDVLFTTNSLETDLQLEQ
                     VNSQIDTYSRRIELLKAAEENAANGTNYFDRYDEAENEFYNRLNQAYMARKEFDVDEQS
                     LKDQGYEQKQIDEFVKTQKNKANEHYYRTISEFSNERNQYEVELSKLVSQKEALEKSKE
                     QYQVVAQKGGTVHLSTPLTTGMVIQGGSLIGTITSKEEELIIETMLPSSDRPRIHVGDE
                     VSLAVGGLNQAEYGTIPGSVISIDEDATIDNENGNVYFKVRVKPEKTYLEDSKGEKVNL
                     SLGMVTETRVKYEKITYMKYLLELIGVKFS"
     PFAM_domain     7943..8077
                     /aSDomain="Biotin_lipoyl_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13533.8"
                     /description="Biotin-lipoyl like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_290_0009"
                     /evalue="5.70E-10"
                     /label="ctg1_290"
                     /locus_tag="ctg1_290"
                     /protein_end="109"
                     /protein_start="64"
                     /score="38.9"
                     /tool="antismash"
                     /translation="IMTKASGEIKEVFIEEGSEVKEGDVLFTTNSLETDLQLEQVNSQI
                     "
     PFAM_domain     8426..8743
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_290_0010"
                     /evalue="4.40E-13"
                     /label="ctg1_290"
                     /locus_tag="ctg1_290"
                     /protein_end="331"
                     /protein_start="225"
                     /score="49.9"
                     /tool="antismash"
                     /translation="VVAQKGGTVHLSTPLTTGMVIQGGSLIGTITSKEEELIIETMLPS
                     SDRPRIHVGDEVSLAVGGLNQAEYGTIPGSVISIDEDATIDNENGNVYFKVRVKPEKTY
                     LE"
     CDS             8994..9389
                     /locus_tag="ctg1_291"
                     /transl_table=11
                     /translation="MSAFVLGREYELQLPNNYVEIDSDEMEYVDGGGVYNWIVAGAVNI
                     VFAAAFGGGAITLVKSIIKSLGSTNVKQKIVGAITKYIAVQAANRIAGMVLGAIWGIAS
                     GSIGDFVANIWDANDTVRYNGVCNALW"
     CDS             9346..9582
                     /locus_tag="ctg1_292"
                     /transl_table=11
                     /translation="MIRYAITGFVMRCGNINKIDILSLFIFIIIASFTLYVRNPALVKY
                     YWILYIVEFFIGVYIAIRLFYIKDFSIKNRNKI"
     CDS             9863..10192
                     /locus_tag="ctg1_293"
                     /transl_table=11
                     /translation="MEYVDGGAWNSVQNIGYALDVLIWVGGVVTGVIGIVGSVREILRR
                     NARGLVVQATSTLLRKVGLSAAVFLASSIVSGLELFLNLSLGQGIAMVLDRIDKVRYSG
                     AIELW"
     CDS             10233..10439
                     /locus_tag="ctg1_294"
                     /transl_table=11
                     /translation="MWIIASLYISCIIISIIVYFVGCNKISRYEINKKELEYSNAIKLF
                     KTSLGILIIGFSLLTLGLIIRII"
     CDS             10994..11203
                     /locus_tag="ctg1_295"
                     /transl_table=11
                     /translation="MFALTGCLISLILSFVNMRRELYDYIIFVGIVFTIPAIATMRKMF
                     LRLKEIKVISIIIGNLNLVFMPNS"
     CDS             11616..12011
                     /locus_tag="ctg1_296"
                     /transl_table=11
                     /translation="MSAFVLGREYELQLPNSYVDVDRDEMEYLDGGQFYSKNDCRLALA
                     ALAINPSTYLNIAMSYTLAKLLINKVSAMFGGVAGWAVGVVLTYAGSQIITFGAALCRG
                     AINRGVDISWNWNIFKDSLGVVYSVRY"
ORIGIN
        1 tacaatggta ataatataaa atattaatta ataaaaatta tttgttttaa agttataatt
       61 ataaaagtta ggagcttaat taaagagtaa ttatgaaaaa tggatttaat aaatttataa
      121 aattaatcaa aggtaaagat aaaaatatag agaagggaag tgataatatg aaaaataaga
      181 tgcctgttat atttataggt catggaagtc ctttaaatat gattttagat aatgattata
      241 caagagattt aagtgaattc ggaaaaagct tagaaaggcc aaaggcaata cttgtaatat
      301 cagcccattt ttatacaaag ggttcatata taacttattc agataaacct aaacaaatat
      361 atgattttta cggctttcca gatgaaatgt acaaaatgga gtatagacca gatgggggaa
      421 aagaatatgc attaaaaaca tatgagctct taaaggattt tggagttaag ttaacagaag
      481 attggggatt agaccatggt tcttggggaa tattgcattt tttattccct aaagcagatg
      541 tgccaacttt ccaactaagt ataaatgctg atttaacaga agaagaacat tataatatgg
      601 caaagaaatt attaaaatta agagaagaag gagttttaat aattggaagc ggcaatatat
      661 cccacaattt aagagtaatg gaatatgaaa tggatgctaa gcctcttgaa tttgctttag
      721 aatttgatga atatattaaa aagtcattat tagagggaaa tcatgaaaat gtgattaatt
      781 ataaaaaatt aggagaaata gcaagtctag cagttccaac tcctgatcat tatcttccgc
      841 tgatttatac aatagccctt caagaagaag gagaaaaaat agattttatt catgaaaaca
      901 tacaaaatgg ttcaatggct atgagaagtt ttataatcaa ttgatagtta ccaattgata
      961 attaaggaga actttctctt tattttacat ttaaaatttt aacttatatg atataactta
     1021 tgtgatataa taatgctgga ttaaatgttg tccaataatt atatatatat ttaatacaat
     1081 aattttatct gaaaggaagt attgaatttg aaaataaaaa gttttctaaa gctagtagag
     1141 atacaaacaa aggctgcaag tgtaattcca tattttttag cctccttatt tgtatattat
     1201 agatataata tttttaattt taaaaatgca ataataatgt ttttctcaat gcttattttt
     1261 gatatgacaa ctacagcaat aaataattat atagactatg caaaggcaat aaaaaaagaa
     1321 ggatttggat atgaaagtca taatgcaatt gtaagagata aattaaatcc agatcatgta
     1381 agatatttaa tatatgcaat gttaggaaca gcagctcttt taggattatt attagttgca
     1441 aatacaaata ttgtggtttt attacttggt gcattagcct ttgttattgg tattacttat
     1501 acctttggac caattccaat ttctagaact ccctttgggg aattattttc cggtcttgca
     1561 atgggatttt tattaacttt tataactatg tatatacata tatttgacag agggatatta
     1621 aatatcgatt atacaaattt taatagtata aatatagtat ttaacttaaa agaacttgtt
     1681 attttattta tagtttgctt acctgcaata acaggaattg caaatattat gttggcaaat
     1741 aatatctgtg atatagaaga tgatatagta aataagagat atactcttcc aatttatata
     1801 ggcaaggaaa atgcccttaa attatttaag tggctatatt atattggtta tatggcaatt
     1861 gttatagccg ttgttattag agttcttcct ctttattctc ttttatcagt tttagtacta
     1921 aaaaaggtca aggaaaatat agataaattt aatgaacttc aaactaaaaa agatactttt
     1981 ggattagcag ttgaaaactt tgcccttact aatattgtac tagctattac tattttagtt
     2041 ggagtaataa tataatgaat tatgtttata tgttagaatg ttctgatgga agtttatata
     2101 caggatggac aaacaactta gaaaaaagaa ttgcagctca taataatgga aagggagcaa
     2161 aatatacaag ggtaaggctt ccagtaaaat tagtttatta tgaagaatat gaagataaaa
     2221 tagaagcaat gaaaagggaa tatgaaataa aacaattatc aagaaaagaa aaggtaaagt
     2281 taattaaatt tcaataaaat attatagtaa atttatattt aattatggga ttaatgcaaa
     2341 aaatggaatg ttgaaagtat tttttgtaat aatccttttt tattaattaa aatataaact
     2401 attcaggaaa ttaagtaaaa aatataaatg tattcaatat atttacaaaa aagttaattt
     2461 tattgtataa taagaagaca atttaatact tgtgggggaa aatatatgaa tatattgtta
     2521 gtagaagatg atacacttca aagtagtata ttaagaaaaa taatagagaa gaactacatt
     2581 gatataagag tatatgaagc aaaatctgaa aaagaagcca tgtatataat tgaaaaagaa
     2641 gaaatagatt tattctttat agagatgaac ataaagcaga aatctggatt aacattagca
     2701 gagaatataa gaaaaattga aaaatatgaa ttaactccta tagttttcat tagtaaagaa
     2761 attgattata ttataacagc atttaaaaaa gttaattgtt atgatttttt aacaaaacca
     2821 ataagtgtaa ataatattaa aaaaataatt gataagtttt taaggcataa aaataaaatt
     2881 actaatgaaa gttataattt ttttaaaacc atagatggta atgatgtaag ggtatataca
     2941 aaagatataa tatttataga gttttattta aaaagctgta ttttacatac tttgcatgga
     3001 gaatacaaaa taaaatcaga tggattaaat aaaatacttg ataaaataaa taatgacaat
     3061 attatacgaa ctcataaatc ttttgcagta aatttagaac atataaaaga aataagaaaa
     3121 gtcaatttta aactttggga aataagtttt tacaattatg ataaaacaag cgaattaagt
     3181 tatagttata gaaaatatat aaagaatatt attaagtaaa tcattaaagt aaggattaga
     3241 atttttattt atgctaatcc ttacttttta ttattaaact aaaaaattaa ggattatata
     3301 tagaaataaa aattgcacta aaaggaattt tattccaaaa aattcttttc gatatagatt
     3361 ttttatattt ccctctaaaa tttaacataa taaattcttc ttttattaga ataattatag
     3421 aaagtagagg aaaggttaat ccattggaat aaaaaattaa cttgaattaa aagaaaatta
     3481 ggtaggtaaa gtttagcata catagcgcgc ggattaatta agtgtatgtt aaatatttgt
     3541 atatatctaa tattctttta aaatatataa ataatggagg agaattatga gcgcttttgt
     3601 attaagcaga gagtatgaat tacaattacc aatcagctat gtagatattg acagagctga
     3661 aatggagtat gttgatgggg gatattctat ccctgtgaat gtagcgatgt tatcatctgc
     3721 atattgtctt tcctatgcaa caaccttatg gattcaaggc gtaatttcat tttccaacat
     3781 cttagttatt gcgaaagaaa ttagaggaca tgctgcagca tattatggat tatctggttt
     3841 atcagcgtta ggaatttcta acagcacatt agaagaaatg aagagaagtg ctaatccaat
     3901 cgatataaga gatggatatg atccaagatg gtatgttgta gctgcttgcg aactaatctg
     3961 gacattacca ggttaaaaaa taaaatttaa ggatagcaag tgaaaaaaat aatattagga
     4021 ataagcatat tatttatcag tattataagt attatgcttt taatagcagt aaaagaacaa
     4081 agggatatag ttgcaagata tataactgat gagcattata ggtataagcc ggttgaaatg
     4141 aaagatgaag tatattttcc atcaactgtt gacttaggta atgaaaatgg tttgaaagaa
     4201 ataggttact taagtgtaaa aaataaaagc atagttaatg atttattatt aattgtggga
     4261 aaagtacttg ttgatgagag tgataaaaac tatactcatt tttctgttat agatgatttt
     4321 gcaatgaatt atactaaagg agaatatttg caagataaga gtataattaa ttatactatg
     4381 aataagtata atgactttgt tctttgcaat gataaaaatg atcttgaaac tagaattaca
     4441 ctagaaaaag atgtgttata tatgcttcaa gatgagttta aaactataga atataaagca
     4501 gatgatttca aaaatagtga tgatagatat tatatatatg ttaattcacc gcaaaagaaa
     4561 ttacatggta gaacttttga tgatccaata atatttatgg gatgtatatt agttaaagat
     4621 aacaagttat actatggaaa ttttgataat gaaataaaag gtgaattatt aaataaaata
     4681 atattatata taaaataaat tatcacaatt tttggatatg aaaatatttt atagtactaa
     4741 ttgttcttag aaacaaaggc ttccggttct tattataaca cctgaagtta taataaaatc
     4801 ggaagctatt attttgttaa agtaaggatt aaagttattt ataatattta aaacaaaact
     4861 aaattgacaa aaagtggatt taagggaata ttaatttaag atattccttt taatatttat
     4921 tctttatatt ttattcccaa aattaacaca atttctttcc tttttattaa aatatttgta
     4981 gaaaatggag gaaagatttt atgagaaata aatatttagt gaaacagcat gatataacag
     5041 attgtgcagc agcaagttta gcaacaatat gtatgtatta taaaaaagaa ataactataa
     5101 caaaactaag agatatactt ggaactgata taaaaggaac aactttagca ggtttagaaa
     5161 atggtgcaaa aaaattaggc tttgatacta aagctatcag agttgataaa gagggattta
     5221 agagcaaata tacacttcct gcaatcgctc atgttattac aaaggaagga ctgacacact
     5281 ttgtgattat acacaaagtc aaaaaggaag aagtaataat attagatcct gctaagggaa
     5341 aagaaaaggt taacattgat aagttttttg aaagttttga tggaatatta cttttattag
     5401 taccaaataa agaatttaat cctggcaaaa taaaagggca aggtattctt aataagttta
     5461 ttcaattatt acttcctcaa aagtcacttt ttatatatag cataatagca tcagttatat
     5521 taactatatt gggaatagca tcttcattct ttaataaaat tcttatggat gaaattcttc
     5581 catatagttt aaaaaatcaa cttaatattt ttgtaatagg atttttggtt ttaggaataa
     5641 ctcaaatagg acttggggca ataaggcagc atatgctttt atatttatca cagaaaattg
     5701 atattccttt attattaggt tatttcaagc atgtttataa actgcctatg aagttttttg
     5761 caacgcgaaa ggtaggagat atattaacta ggtttagtga tgcctttaca ataaaaaata
     5821 tactaacttc agtttcttta tcattattaa tggatattgt tctggcagta gcatcagctt
     5881 ctattctata tgtaatgaat cagaagttat ttattgtaat attagtttta accttaatta
     5941 gtgcagcttt aatatatata tttaaacatc cttataagaa aattaatata gaacaaatgg
     6001 aagcaggagc cagattaaat agtcaaatta tagaaagctt aagaggaatt gaaacaataa
     6061 aggtaaattc ggcagaagaa aaaagtatag aaaagttaga aaatgaatat ataagaaatt
     6121 taagaattgc cttcaaagaa ggagttctgt ctaatattca aggatctata tcaggagcag
     6181 tatctaccat gggtaatctt gtacttatgt atattggagc aagaatgata atggatggag
     6241 atataacttt aggaagtctt atggcattta caactttatc aggatatttt atggatccta
     6301 ttggaagact tataagcctt caattaagta ttcaagaagc tagtatttcc ttaaaaagaa
     6361 tttctgaaat atatgaagtt gaaaaagaac agcttgaaga agattttgat aaggtaaaac
     6421 tagaaaagat agatggagat atagaactta ataatattac ttttagatac ggaagcagat
     6481 caccagtttt aaaaaatgta agtataaaaa tacctaaagg taagaaagtt gctttagttg
     6541 gtgaatcagg aagcggaaaa actacaatat ctaagttaat attaaagtat tatactcctg
     6601 aagaaggaaa aataaatatt aatggatata atattgaaga gttagattta tataatttaa
     6661 gacagaatat ttcttatgtt cctcaaaatg tggaactatt ttcaggaact attaaggata
     6721 atataacttt aggaagacca aatgcaagtt atgaagaaat aaaagcagct tgtgaaaatt
     6781 caggctgcag cgaatttatt gaaaggctgc ctggtaaata tggaaccttc ttagaagaag
     6841 ctggtggcgg gctatcaggt ggtgaaaaac aaaggctagc attagcaaga gccttaatta
     6901 agaagtctaa atttatgata ttagatgaag ctactagtaa cttagatttt ataagtgaag
     6961 caaaagtatt taacacttta tttaaaaagg gaaaaaatat aacaatgctt ataatagccc
     7021 atagactttc aactattaga aattgcgaca ttatttatgt tatggacaag ggtagagtag
     7081 ttgaagttgg tgaccatgaa agcttgttaa ggaaaaaggg ttattattat agattatata
     7141 taagtcaggt aggatctttt gaagaaaaag aaatagtatt taatgaaaat ttaaatatgg
     7201 gtacagaaga tgtctcttct aaagagatta agttagaaga agatattata gaggagggtg
     7261 aaatttatga gtacaattga aaaaataata gtaagggaaa ataaaacttt aaagttaaat
     7321 aacgttttaa taagagaagt aagtgaaaat gaattaattg atatcgaaag aataagttac
     7381 atgatggata gctatataaa atcaaaaggc gcttcaacta ttggaccaat gattaattat
     7441 tctggaattg aaactgatga aaatggtgag gctaagataa aaatgaaatt aatggttcaa
     7501 cttaagaatt caatttataa agttgaaaag ccttatagta taaagccgca aattagggta
     7561 acaaattgtt tatttgcaag gtttactgaa aaacaagaaa atctacaata tgcttatcaa
     7621 aaacttggtg tatatgcttt tgaaaatgat ataaagttaa aaggagactc atatacagtt
     7681 tttgttaagc aagaagaaga taatatagtg gcagatgtat ttatggaaga agcgaaaggt
     7741 ggagaattac ttgaaagtat ataatttaaa tgaaattact gatagtaaag tactttatga
     7801 taaaaagcca ccagctttta tgaattatat tattttgata gttttagcat taatagttgc
     7861 agctttaatt tgggcaaata aatctgtaaa aacatatatg gtaaagggac aaggtctagt
     7921 tgtttcagaa aataagtctc atattatgac taaagcatca ggagaaataa aggaagtatt
     7981 cattgaagaa ggaagtgaag taaaagaagg agatgtacta tttacaacaa atagtttaga
     8041 aacagacctt cagttagagc aagtaaattc gcaaatagat acttatagta gaagaattga
     8101 attattgaaa gcagcagaag aaaatgcagc taatggtaca aattattttg atagatatga
     8161 tgaagcagaa aatgaatttt ataatagatt aaatcaagcc tacatggcaa gaaaggaatt
     8221 tgatgtagat gaacagtcgt taaaagacca aggatatgag caaaagcaaa tagatgagtt
     8281 tgtaaaaaca caaaaaaata aagcaaatga acattattat agaactattt cagagttttc
     8341 taatgagaga aatcaatatg aagtagagct ttcaaaatta gtttcacaaa aagaagcctt
     8401 agagaaaagt aaagagcaat atcaagtagt agctcaaaaa ggtggaacag tacatttaag
     8461 cacaccatta acaactggaa tggtaattca gggaggaagc ttaattggaa caataactag
     8521 caaggaagaa gaattaatta tagaaacaat gctaccttct agtgatagac caagaatcca
     8581 tgttggagat gaagtttcat tagcagttgg gggtcttaac caagcagaat atggaacaat
     8641 acctggtagt gtcattagta ttgatgaaga tgcaaccatt gataatgaaa atggaaatgt
     8701 atatttcaaa gtaagggtta agcctgaaaa aacatatcta gaagattcta aaggagaaaa
     8761 agttaattta agcttaggaa tggtaacaga aacaagagtt aaatatgaaa agataactta
     8821 tatgaaatac ctattagaat taataggagt aaagtttagt taattaattt gcattaaaag
     8881 aaaattagaa agataaattt tagcatacat agcgcgcgaa ttaattaagt gtgtgttaaa
     8941 tatttacaaa tttctaatat tcttttaaaa tatataagta atggaggaga attatgagcg
     9001 cttttgtatt aggcagagaa tacgaattac aattaccaaa taactatgtt gaaattgaca
     9061 gcgatgaaat ggagtatgtt gatggaggtg gtgtttataa ctggatagtt gcaggagctg
     9121 taaacatcgt atttgctgct gcttttggtg ggggagctat aacgttggtt aaaagtataa
     9181 ttaaatcact tggttcaacc aatgtaaaac aaaaaattgt aggagcaatt acaaaatata
     9241 ttgcagttca agcagcaaat agaatagcag gaatggtatt aggagcaatt tggggaatag
     9301 cctctggttc tataggagac tttgttgcaa atatatggga tgctaatgat acggtacgct
     9361 ataacggggt ttgtaatgcg ttgtggtaat ataaataaaa ttgatatatt aagtttattt
     9421 atatttataa ttatagcctc atttacttta tatgtaagaa atccagcatt agtaaagtat
     9481 tattggattt tatatattgt agagtttttt ataggagtat atatagctat tagactattc
     9541 tatattaagg acttttcaat caaaaataga aataaaattt aatatggagt atgaataata
     9601 atgtaaatta tcaagagagt tagtgttaat atcctaactc tcttttgata aaagaataat
     9661 tattaaaaag ttaagagaaa attttatact aaatcttcta aaaagatatt aaatacttat
     9721 tagaaattat aagttttaga tatttaaaat tattaaatat acccttaaaa tcaatatata
     9781 aataatggag gagaataaaa tgagcgcatg agggtatgct ttacaattag caaatagcta
     9841 tgttgaaatt gacaataatg aaatggagta tgttgatgga ggtgcttgga attcagtaca
     9901 aaacattgga tatgcactag atgttctaat atgggttggt ggagtagtta ctggagttat
     9961 tggaatagtt ggttcagtaa gagaaatatt aagaagaaat gcaagaggat tagttgtgca
    10021 agcaactagt actttactaa ggaaagttgg cttatcagca gcagtttttt tagcaagtag
    10081 tatagtatct ggattagaat tgtttttaaa tctttcgttg gggcaaggaa ttgcaatggt
    10141 tctagataga atagataagg taagatatag tggtgcaata gagttgtggt agtttatatt
    10201 tgaataataa gcattttgga aggatgagaa gtatgtggat aattgcaagc ctttatattt
    10261 cttgtatcat tatatctata atagtatatt ttgtaggttg taataaaata tctagatatg
    10321 agattaataa aaaggaatta gaatattcaa atgctataaa attatttaaa acttcgttag
    10381 gaattctaat tataggattc agtttattga cattaggatt gataataaga attatttagc
    10441 gaataaatat tatgaattta aaaaagtcta attaaattaa taagctttaa aggaattata
    10501 gtaataatga ttcttttaaa gcttcttatt atacaataaa agaaatggcg agacatagta
    10561 gttaagaata tgaatttctt tgaaataaat atttaatttt ttaatttgta agggaagtat
    10621 agaaattaat taaaaatata aaaacggagg agtaaagatt aaaaaaataa tgtggacttg
    10681 tatatagtaa tctattattt gctttttcga ttataaaaga aaaagagaaa tattaaaaat
    10741 agtgttatgt aatttaaatt taatgtataa catcataaat aatatatagt ttaggagaat
    10801 tatatttaat atttctagga ggagccctat ctattgctac tactatgaat atggaaggaa
    10861 ctgaggaaag aggttttata ccagtaatat tatcagtagc agtagccgta tggtttgtta
    10921 aaaagaatta tgaaaactat atgagctttt acttagataa aaagtatgca aaaaaatatt
    10981 ttttaaaaat tcaatgttcg ccttaacagg atgtttaatt tctcttatct tatcttttgt
    11041 taatatgaga agagaattat atgattatat catttttgtg ggaatagtat ttacaatacc
    11101 agctatagct actatgagaa aaatgttctt aaggttaaaa gagataaaag taatttcaat
    11161 aattatagga aatttaaatc tagtttttat gccaaatagc taatagtgct atattaaata
    11221 caactcttac aaatcaattc ttttcgaaat taggcttgaa aagcctaacg catcaatata
    11281 ttaaaattta ttaaacttaa agaaccgccg tgtaccagac cggtacgcac ggtggtgtga
    11341 gaggacggaa aataaaataa ttattttcct cctactcgat tttaagtaca ataaagagaa
    11401 agcggtctta ctaaaatatc tattaaaata atgatacaga aagtgaattt tataatagat
    11461 tatcaaaagc ttatatagat ataaatgaat tgtacttaaa agaaaattag aaagataaat
    11521 tttagcatac atagcgcgcg aattaattaa gtgtgtgtta aatacttaca aatttctaat
    11581 attcttttaa aatatataag taatggagga gaattatgag cgcttttgta ttaggcagag
    11641 aatacgaatt acaattgcca aatagctatg tagatgttga cagggatgaa atggagtatt
    11701 tagacggggg gcagttttat tctaaaaatg attgtcgcct agctttagct gcattagcaa
    11761 taaatccttc cacatacctt aatattgcaa tgtcatatac tttagcaaaa ttgcttatta
    11821 ataaagtatc agctatgttt ggaggcgtgg ctggatgggc agtgggagta gttctgacat
    11881 atgcaggatc tcaaataatt acttttggag cagcgttatg cagaggggca ataaatagag
    11941 gagtagatat ttcatggaat tggaatatct ttaaggacag tttaggagtt gtatattctg
    12001 taagatatta aacaattatt tatttaacta atatttatta taatcataaa tacaatattt
    12061 tattacgagt atttaagaat atataaagta ggtggattaa atgaaacaac aaaatattaa
    12121 tgtgatatat ttcttatcta atattagttt ttatttttgt attagttata tgataataat
    12181 ggactacttg aattataatg attatttatg gggagtagca actttggggt tagttctatc
    12241 ttttctattt tcattaattc cagatatgtt tattaattta
//
