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Overview
4.1
4.2
4.3
4.4
4.5
4.6
4.7
4.8
4.9
4.10
4.11

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LT575476.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | RRE-containing | 206,655 | 225,430 |
Region 4.2 | lanthipeptide-class-ii | 435,027 | 461,398 |
Region 4.3 | proteusin | 1,073,505 | 1,093,756 |
Region 4.4 | T3PKS | 2,554,851 | 2,596,008 |
Region 4.5 | NRPS,T1PKS | 2,828,808 | 2,913,387 | N-myristoyl-D-asparagine / cis-7-tetradecenoyl-D-asparagine / (R)-N1-((S)-5-oxohexan-2-yl)-2-tetradecanamidosuccinamide | NRP + Polyketide:Modular type I + Polyketide:Trans-AT type I | 21%
Region 4.6 | siderophore | 2,924,656 | 2,938,253 | staphylobactin | Other | 18%
Region 4.7 | transAT-PKS,NRPS | 3,023,223 | 3,091,221 |
Region 4.8 | cyclic-lactone-autoinducer | 3,763,404 | 3,783,934 |
Region 4.9 | ranthipeptide | 3,895,135 | 3,916,423 |
Region 4.10 | RRE-containing | 4,037,317 | 4,058,921 |
Region 4.11 | phosphonate | 4,190,877 | 4,231,776 | enduracidin | NRP | 4%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | RRE-containing | 206,655 | 225,430 |
Region 4.2 | lanthipeptide-class-ii | 435,027 | 461,398 |
Region 4.3 | proteusin | 1,073,505 | 1,093,756 |
Region 4.4 | T3PKS | 2,554,851 | 2,596,008 |
Region 4.5 | NRPS,T1PKS | 2,828,808 | 2,913,387 | N-myristoyl-D-asparagine / cis-7-tetradecenoyl-D-asparagine / (R)-N1-((S)-5-oxohexan-2-yl)-2-tetradecanamidosuccinamide | NRP + Polyketide:Modular type I + Polyketide:Trans-AT type I | 21%
Region 4.6 | siderophore | 2,924,656 | 2,938,253 | staphylobactin | Other | 18%
Region 4.7 | transAT-PKS,NRPS | 3,023,223 | 3,091,221 |
Region 4.8 | cyclic-lactone-autoinducer | 3,763,404 | 3,783,934 |
Region 4.9 | ranthipeptide | 3,895,135 | 3,916,423 |
Region 4.10 | RRE-containing | 4,037,317 | 4,058,921 |
Region 4.11 | phosphonate | 4,190,877 | 4,231,776 | enduracidin | NRP | 4%

No secondary metabolite regions were found in these records:
  NZ_LT575473.1
  NZ_LT575474.1
  NZ_LT575475.1

Compact view
NZ_LT575476.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 206,655 - 225,430 nt. (total: 18,776 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.1 |  | 0.15 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000554.1 |  | 0.15 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000504.1 |  | 0.15 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000584.1 |  | 0.14 | RiPP | colicin V | Escherichia coli
BGC0000294.1 |  | 0.14 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000548.1 |  | 0.13 | RiPP | salivaricin A | Streptococcus salivarius
BGC0001607.1 |  | 0.13 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0000587.1 |  | 0.13 | RiPP | microcin H47 | Escherichia coli
BGC0000589.1 |  | 0.13 | RiPP | microcin M | Escherichia coli Nissle 1917
BGC0000599.1 |  | 0.13 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.1 |  | 0.46 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000554.1 |  | 0.45 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000504.1 |  | 0.45 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000584.1 |  | 0.43 | RiPP | colicin V | Escherichia coli
BGC0000294.1 |  | 0.43 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000548.1 |  | 0.42 | RiPP | salivaricin A | Streptococcus salivarius
BGC0001607.1 |  | 0.42 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0000587.1 |  | 0.42 | RiPP | microcin H47 | Escherichia coli
BGC0000589.1 |  | 0.42 | RiPP | microcin M | Escherichia coli Nissle 1917
BGC0000599.1 |  | 0.42 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NZ_LT575476.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 435,027 - 461,398 nt. (total: 26,372 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.1 |  | 0.35 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000525.1 |  | 0.33 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001579.1 |  | 0.31 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000500.1 |  | 0.29 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.28 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.1 |  | 0.26 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001787.1 |  | 0.24 | RiPP | suicin 3908 | Streptococcus suis
BGC0000561.1 |  | 0.24 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000498.1 |  | 0.24 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0000517.1 |  | 0.23 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.1 |  | 0.68 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000525.1 |  | 0.66 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001579.1 |  | 0.64 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000500.1 |  | 0.62 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.61 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.1 |  | 0.60 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001787.1 |  | 0.57 | RiPP | suicin 3908 | Streptococcus suis
BGC0000561.1 |  | 0.57 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000498.1 |  | 0.57 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0000517.1 |  | 0.57 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg4_403 - Putative Class II

ctg4_402 leader / core peptide
  MKMAVLKNPVLRNKIGYEGENPSGNVLEEIKDHDVVGA - IDhaWGDhbVLDhbDhbLACLGADhaYALGDKGQVCDhbADhbVECINNCRK
ctg4_404 leader / core peptide
  MMRAELNQISGM - IEENELELLAGNEDVKGGWDhbPVADhbVVIDhaVIGLDhbMNADhbPCPDhbDhaACDhbKDhaC
allorf_0444250_0444393 leader / core peptide
  LSILVIYFFLNEIRYG - RRRELFDhaLKCKEFYEKERDhbKEGIRLLEECNF

#### Lanthipeptide(s) for ctg4_405 - Putative Class II

ctg4_402 leader / core peptide
  MKMAVLKNPVLRNKIGYEGENPSGNVLEEIKDHDVVGA - IDhaWGDhbVLDhbDhbLACLGADhaYALGDKGQVCDhbADhbVECINNCRK
ctg4_404 leader / core peptide
  MMRAELNQISGM - IEENELELLAGNEDVKGGWDhbPVADhbVVIDhaVIGLDhbMNADhbPCPDhbDhaACDhbKDhaC
allorf_0444250_0444393 leader / core peptide
  LSILVIYFFLNEIRYG - RRRELFDhaLKCKEFYEKERDhbKEGIRLLEECNF

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg4_402 - Class II
  Cleavage pHMM score: 0.10
  RODEO score: 0
  Monoisotopic mass: 3832.9 Da
  Molecular weight: 3835.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3853.4 Da N = 1
    3871.5 Da N = 2
    3889.5 Da N = 3
ctg4_404 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 4798.4 Da
  Molecular weight: 4801.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4819.5 Da N = 1
    4837.5 Da N = 2
    4855.5 Da N = 3
    4873.5 Da N = 4
    4891.6 Da N = 5
    4909.6 Da N = 6
allorf_0444250_0444393 - Class II
  Cleavage pHMM score: -2.50
  RODEO score: 0
  Monoisotopic mass: 3913.0 Da
  Molecular weight: 3915.5 Da
  Number of bridges: 2
ctg4_402 - Class II
  Cleavage pHMM score: 0.10
  RODEO score: 0
  Monoisotopic mass: 3832.9 Da
  Molecular weight: 3835.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3853.4 Da N = 1
    3871.5 Da N = 2
    3889.5 Da N = 3
ctg4_404 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 4798.4 Da
  Molecular weight: 4801.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4819.5 Da N = 1
    4837.5 Da N = 2
    4855.5 Da N = 3
    4873.5 Da N = 4
    4891.6 Da N = 5
    4909.6 Da N = 6
allorf_0444250_0444393 - Class II
  Cleavage pHMM score: -2.50
  RODEO score: 0
  Monoisotopic mass: 3913.0 Da
  Molecular weight: 3915.5 Da
  Number of bridges: 2

NZ_LT575476.1 - Region 3 - proteusin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,073,505 - 1,093,756 nt. (total: 20,252 nt) Show pHMM detection rules used
proteusin: (PoyD or TIGR03793)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | proteusin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000703.1 |  | 0.14 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001810.1 |  | 0.14 | Polyketide | trehangelin | Polymorphospora rubra
BGC0001735.1 |  | 0.13 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0001686.1 |  | 0.11 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000939.1 |  | 0.11 | Other | aerobactin | Grimontia hollisae
BGC0001870.1 |  | 0.10 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001782.1 |  | 0.10 | Other | spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G | Streptomyces sp. SCSIO 03032
BGC0000947.1 |  | 0.09 | Other | vibrioferrin | Vibrio alginolyticus
BGC0000943.1 |  | 0.09 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001767.1 |  | 0.09 | NRP | salinichelins | Salinispora pacifica CNY331

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000703.1 |  | 0.43 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001810.1 |  | 0.43 | Polyketide | trehangelin | Polymorphospora rubra
BGC0001735.1 |  | 0.42 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0001686.1 |  | 0.37 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000939.1 |  | 0.37 | Other | aerobactin | Grimontia hollisae
BGC0001870.1 |  | 0.35 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001782.1 |  | 0.35 | Other | spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G | Streptomyces sp. SCSIO 03032
BGC0000947.1 |  | 0.34 | Other | vibrioferrin | Vibrio alginolyticus
BGC0000943.1 |  | 0.34 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001767.1 |  | 0.33 | NRP | salinichelins | Salinispora pacifica CNY331

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT575476.1 - Region 4 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,554,851 - 2,596,008 nt. (total: 41,158 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001962.1 |  | 0.34 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001938.1 |  | 0.33 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001077.1 |  | 0.21 | Terpene, Polyketide | alkyl-O-dihydrogeranyl-methoxyhydroquinones | Actinoplanes missouriensis 431
BGC0000221.1 |  | 0.17 | Polyketide | erdacin | uncultured soil bacterium V167
BGC0000700.1 |  | 0.17 | Saccharide | istamycin | Streptomyces tenjimariensis
BGC0000228.1 |  | 0.17 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000527.1 |  | 0.16 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001184.1 |  | 0.16 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.16 | Other | bacilysin | Bacillus sp. CS93
BGC0001197.1 |  | 0.16 | Polyketide | frankiamicin | Frankia sp. EAN1pec

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001962.1 |  | 0.67 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001938.1 |  | 0.66 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001077.1 |  | 0.54 | Terpene, Polyketide | alkyl-O-dihydrogeranyl-methoxyhydroquinones | Actinoplanes missouriensis 431
BGC0000221.1 |  | 0.49 | Polyketide | erdacin | uncultured soil bacterium V167
BGC0000700.1 |  | 0.48 | Saccharide | istamycin | Streptomyces tenjimariensis
BGC0000228.1 |  | 0.48 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000527.1 |  | 0.47 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001184.1 |  | 0.47 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.47 | Other | bacilysin | Bacillus sp. CS93
BGC0001197.1 |  | 0.47 | Polyketide | frankiamicin | Frankia sp. EAN1pec

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT575476.1 - Region 5 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,828,808 - 2,913,387 nt. (total: 84,580 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000389.1 |  |  | 0.79 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  |  | 0.76 | NRP | sevadicin | Paenibacillus larvae
BGC0001023.1 |  |  | 0.71 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0001050.1 |  |  | 0.68 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000457.1 |  |  | 0.65 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001833.1 |  |  | 0.64 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001767.1 |  |  | 0.61 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001671.1 |  |  | 0.61 | NRP | monobactam | Agrobacterium tumefaciens
BGC0000460.1 |  |  | 0.59 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0000349.1 |  |  | 0.59 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.72 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  | 0.70 | NRP | sevadicin | Paenibacillus larvae
BGC0001023.1 |  | 0.68 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0001050.1 |  | 0.67 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001767.1 |  | 0.67 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0000457.1 |  | 0.67 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000349.1 |  | 0.66 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338
BGC0001833.1 |  | 0.65 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000460.1 |  | 0.65 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0001211.1 |  | 0.64 | NRP | albachelin | Amycolatopsis alba DSM 44262

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 2828807 - 2913387:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-asn) + (val - redmal) + (ohmal) + (X) + (mal) + (gly - cys) + (cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg4_2581: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (1345..1741): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg4_2582: gly - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (508..903): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLVWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1586..1989): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg4_2583: mal
  PKS_AT (537..830): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 91.7%
    inactive: 83.3%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 115.1
    inactive: 73.8
    Methoxymalonyl-CoA: 53.1
    Methylmalonyl-CoA: 44.4
    Isobutyryl-CoA: 23.4
    Propionyl-CoA: 22.4
    Benzoyl-CoA: 11.3
    Ethylmalonyl-CoA: 9.3
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    CHC-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg4_2584: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (501..899): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ssGsLGGVCK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      70% (weak)
ctg4_2585: ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (34..438): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg4_2586: mal
  PKS_AT (7..289): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 58.3%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 62.3
    Methoxymalonyl-CoA: 40.1
    inactive: 31.0
    Methylmalonyl-CoA: 28.8
    Propionyl-CoA: 11.2
    Isobutyryl-CoA: 8.2
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg4_2590: mal
  PKS_AT (534..828): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 75.0%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 129.4
    inactive: 73.8
    Methoxymalonyl-CoA: 53.6
    Methylmalonyl-CoA: 39.8
    Propionyl-CoA: 24.0
    Isobutyryl-CoA: 18.7
    Benzoyl-CoA: 14.6
    Acetyl-CoA: 10.1
    2-Methylbutyryl-CoA: 9.0
    Ethylmalonyl-CoA: 6.0
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    CHC-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg4_2591: val - mal
  Search NORINE for peptide: strict or relaxed
  AMP-binding (472..871): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVFWIGGvlK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      80% (moderate)
  PKS_AT (1597..1891): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 91.7%
    inactive: 79.2%
    2-Rhyd-Malonyl-CoA: 58.3%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 136.1
    inactive: 78.2
    Methoxymalonyl-CoA: 45.4
    Methylmalonyl-CoA: 37.2
    Propionyl-CoA: 21.8
    Ethylmalonyl-CoA: 13.8
    fatty_acid: 11.8
    2-Methylbutyryl-CoA: 10.0
    trans-1,2-CPDA: 0.0
    Isobutyryl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg4_2595: asn
  Search NORINE for peptide: strict or relaxed
  AMP-binding (464..861): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)

NZ_LT575476.1 - Region 6 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,924,656 - 2,938,253 nt. (total: 13,598 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001408.1 |  | 0.37 | Other | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000941.1 |  | 0.32 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001499.1 |  | 0.31 | Other | aerobactin | Pantoea ananatis
BGC0001870.1 |  | 0.28 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000942.1 |  | 0.27 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0000939.1 |  | 0.27 | Other | aerobactin | Grimontia hollisae
BGC0000946.1 |  | 0.26 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000943.1 |  | 0.19 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000947.1 |  | 0.16 | Other | vibrioferrin | Vibrio alginolyticus
BGC0000774.1 |  | 0.14 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001408.1 |  | 0.69 | Other | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000941.1 |  | 0.65 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001499.1 |  | 0.65 | Other | aerobactin | Pantoea ananatis
BGC0001870.1 |  | 0.61 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000942.1 |  | 0.61 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0000939.1 |  | 0.61 | Other | aerobactin | Grimontia hollisae
BGC0000946.1 |  | 0.59 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000943.1 |  | 0.51 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000947.1 |  | 0.46 | Other | vibrioferrin | Vibrio alginolyticus
BGC0000774.1 |  | 0.44 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT575476.1 - Region 7 - NRPS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,023,223 - 3,091,221 nt. (total: 67,999 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000389.1 |  |  | 0.66 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001844.1 |  |  | 0.63 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000457.1 |  |  | 0.63 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001135.1 |  |  | 0.60 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.1 |  |  | 0.60 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000396.1 |  |  | 0.60 | NRP | nodularin | Nostoc sp. 73.1
BGC0001833.1 |  |  | 0.60 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001826.1 |  |  | 0.57 | NRP | xeneprotides A-C | Xenorhabdus sp. KJ12.1
BGC0001128.1 |  |  | 0.57 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001767.1 |  |  | 0.57 | NRP | salinichelins | Salinispora pacifica CNY331

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.66 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001844.1 |  | 0.65 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000457.1 |  | 0.65 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001135.1 |  | 0.64 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001767.1 |  | 0.63 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001758.1 |  | 0.63 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000396.1 |  | 0.63 | NRP | nodularin | Nostoc sp. 73.1
BGC0001833.1 |  | 0.63 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001826.1 |  | 0.62 | NRP | xeneprotides A-C | Xenorhabdus sp. KJ12.1
BGC0001128.1 |  | 0.62 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 3023222 - 3091221:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ile - ser - ser) + (X - gly)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg4_2714: mal
  PKS_AT (8..290): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    2-Methylbutyryl-CoA: 58.3%
    inactive: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 105.2
    Methoxymalonyl-CoA: 38.6
    Methylmalonyl-CoA: 37.5
    Propionyl-CoA: 33.8
    inactive: 31.3
    CHC-CoA: 20.3
    2-Methylbutyryl-CoA: 18.5
    Ethylmalonyl-CoA: 17.5
    Isobutyryl-CoA: 11.4
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg4_2717: X - gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (1250..1654): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DvayLGGVCK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      70% (weak)
  AMP-binding (2349..2741): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DIvQmGLVWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      80% (moderate)
ctg4_2721: pk - ile - ser - ser
  Search NORINE for peptide: strict or relaxed
  CAL_domain (155..468): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 108.6
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
    NH2: -1.8
  AMP-binding (1143..1551): ile
  NRPSPredictor2: ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      ile
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGFFLGVVFK
    Nearest Stachelhaus code:
      ile
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2193..2604): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (3257..3665): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)

NZ_LT575476.1 - Region 8 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,763,404 - 3,783,934 nt. (total: 20,531 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.17 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.16 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000982.1 |  | 0.04 | NRP, Polyketide | cystothiazole A | Cystobacter fuscus
BGC0000203.1 |  | 0.04 | Polyketide | BE-7585A | Amycolatopsis orientalis subsp. vinearia

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.49 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.46 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000982.1 |  | 0.21 | NRP, Polyketide | cystothiazole A | Cystobacter fuscus
BGC0000203.1 |  | 0.19 | Polyketide | BE-7585A | Amycolatopsis orientalis subsp. vinearia

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT575476.1 - Region 9 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,895,135 - 3,916,423 nt. (total: 21,289 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.25 | RiPP | thurincin H | Bacillus thuringiensis
BGC0001496.1 |  | 0.21 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001550.1 |  | 0.20 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.19 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000504.1 |  | 0.19 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001634.1 |  | 0.19 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001549.1 |  | 0.19 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0000575.1 |  | 0.19 | RiPP | lariatin | Rhodococcus jostii
BGC0001356.1 |  | 0.19 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0000500.1 |  | 0.19 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.58 | RiPP | thurincin H | Bacillus thuringiensis
BGC0001496.1 |  | 0.54 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001550.1 |  | 0.52 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.52 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000504.1 |  | 0.52 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001634.1 |  | 0.52 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001549.1 |  | 0.51 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0000575.1 |  | 0.51 | RiPP | lariatin | Rhodococcus jostii
BGC0001356.1 |  | 0.51 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT575476.1 - Region 10 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,037,317 - 4,058,921 nt. (total: 21,605 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.17 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000547.1 |  | 0.17 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0000557.1 |  | 0.17 | RiPP | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000626.1 |  | 0.17 | RiPP | thuricin | Bacillus thuringiensis
BGC0000527.1 |  | 0.17 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000561.1 |  | 0.17 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000498.1 |  | 0.17 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0001787.1 |  | 0.17 | RiPP | suicin 3908 | Streptococcus suis
BGC0000521.1 |  | 0.17 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000502.1 |  | 0.16 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.48 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000547.1 |  | 0.48 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0000557.1 |  | 0.48 | RiPP | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000626.1 |  | 0.48 | RiPP | thuricin | Bacillus thuringiensis
BGC0000527.1 |  | 0.48 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000561.1 |  | 0.48 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000498.1 |  | 0.48 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0001787.1 |  | 0.48 | RiPP | suicin 3908 | Streptococcus suis
BGC0000521.1 |  | 0.48 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000502.1 |  | 0.47 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT575476.1 - Region 11 - phosphonate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,190,877 - 4,231,776 nt. (total: 40,900 nt) Show pHMM detection rules used
phosphonate: phosphonates

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.28 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000888.1 |  | 0.28 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.28 | Other | bacilysin | Bacillus velezensis FZB42
BGC0002007.1 |  | 0.23 | Terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0001538.1 |  | 0.23 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001444.1 |  | 0.23 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0000937.1 |  | 0.23 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001895.1 |  | 0.22 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000255.1 |  | 0.20 | Polyketide | pederin | Uncultured bacterium
BGC0000495.1 |  | 0.20 | RiPP | actagardine | Actinoplanes garbadinensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.62 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000888.1 |  | 0.61 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.61 | Other | bacilysin | Bacillus velezensis FZB42
BGC0002007.1 |  | 0.56 | Terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0001538.1 |  | 0.56 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001444.1 |  | 0.56 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0000937.1 |  | 0.56 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001895.1 |  | 0.55 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000255.1 |  | 0.53 | Polyketide | pederin | Uncultured bacterium
BGC0000495.1 |  | 0.53 | RiPP | actagardine | Actinoplanes garbadinensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names