GCF_001729805.1_ASM172980v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP017184.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NRPS	1,169,118	1,212,975	turnerbactin	NRP	30%
Region 1.2	thiopeptide	1,542,582	1,568,884	O-antigen	Saccharide	14%
Region 1.3	hserlactone	2,266,857	2,287,495
Region 1.4	siderophore	2,947,385	2,961,813	aerobactin	Other	66%
Region 1.5	arylpolyene	4,388,312	4,431,905	aryl polyenes	Other	100%

No secondary metabolite regions were found in these records:: NZ_CP017185.1

Compact view

NZ_CP017184.1 - Region 1 - NRPS

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Location: 1,169,118 - 1,212,975 nt. (total: 43,858 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.36	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001615.1	0.32	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000401.1	0.32	NRP	paenibactin	Paenibacillus elgii B69
BGC0001184.1	0.27	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.27	Other	bacilysin	Bacillus sp. CS93
BGC0001132.1	0.25	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.1	0.25	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001302.1	0.24	Other	lomofungin	Streptomyces lomondensis
BGC0001197.1	0.24	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001844.1	0.24	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.69	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000401.1	0.65	NRP	paenibactin	Paenibacillus elgii B69
BGC0001184.1	0.60	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.60	Other	bacilysin	Bacillus sp. CS93
BGC0001132.1	0.59	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.1	0.58	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001302.1	0.57	Other	lomofungin	Streptomyces lomondensis
BGC0001197.1	0.57	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001844.1	0.57	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 1169117 - 1212975:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1057

Search NORINE for peptide: strict or relaxed

AMP-binding (456..856): ser

NRPSPredictor2: ser

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

ctg1_1064

Search NORINE for peptide: strict or relaxed

AMP-binding (34..437): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: aMPSQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 90% (moderate)

NZ_CP017184.1 - Region 2 - thiopeptide

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Location: 1,542,582 - 1,568,884 nt. (total: 26,303 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.25	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.16	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.09	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1	0.07	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000981.1	0.07	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.06	Other	lomofungin	Streptomyces lomondensis
BGC0002012.1	0.05	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.05	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000957.1	0.04	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13
BGC0000123.1	0.03	Polyketide	phoslactomycin B	Streptomyces sp. HK803

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.58	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.47	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.34	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1	0.29	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000981.1	0.28	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.24	Other	lomofungin	Streptomyces lomondensis
BGC0002012.1	0.23	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.22	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000957.1	0.19	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13
BGC0000123.1	0.15	Polyketide	phoslactomycin B	Streptomyces sp. HK803

Similar known gene clusters

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Thiopeptides

Core peptide predictions

No core peptides found.

NZ_CP017184.1 - Region 3 - hserlactone

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Location: 2,266,857 - 2,287,495 nt. (total: 20,639 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000386.1	0.23	NRP	malleobactin A, malleobactin B, malleobactin C, malleobactin D	Burkholderia thailandensis E264
BGC0000255.1	0.21	Polyketide	pederin	Uncultured bacterium
BGC0002009.1	0.19	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000025.1	0.18	Polyketide	avermectin	Streptomyces avermitilis
BGC0000843.1	0.18	Other (Non-NRP beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0000019.1	0.18	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001909.1	0.16	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000928.1	0.16	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.16	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000842.1	0.15	Other (Non-NRP beta-lactam)	carbapenem MM4550	Streptomyces argenteolus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000386.1	0.56	NRP	malleobactin A, malleobactin B, malleobactin C, malleobactin D	Burkholderia thailandensis E264
BGC0000255.1	0.53	Polyketide	pederin	Uncultured bacterium
BGC0002009.1	0.51	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000025.1	0.50	Polyketide	avermectin	Streptomyces avermitilis
BGC0000843.1	0.50	Other (Non-NRP beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0000019.1	0.49	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001909.1	0.47	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000928.1	0.46	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.46	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000842.1	0.45	Other (Non-NRP beta-lactam)	carbapenem MM4550	Streptomyces argenteolus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP017184.1 - Region 4 - siderophore

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Location: 2,947,385 - 2,961,813 nt. (total: 14,429 nt) Show pHMM detection rules used

siderophore: IucA_IucC

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001499.1	0.56	Other	aerobactin	Pantoea ananatis
BGC0001498.1	0.37	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001572.1	0.29	Other	desferrioxamine E	Pantoea agglomerans
BGC0001713.1	0.28	Other	ochrobactin	Ochrobactrum anthropi
BGC0001555.1	0.27	RiPP	colicin V	Escherichia coli chi7122
BGC0000939.1	0.26	Other	aerobactin	Grimontia hollisae
BGC0001870.1	0.24	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0001478.1	0.22	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.21	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.21	Other	desferrioxamine	Streptomyces argillaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001499.1	0.82	Other	aerobactin	Pantoea ananatis
BGC0001498.1	0.69	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001572.1	0.63	Other	desferrioxamine E	Pantoea agglomerans
BGC0001713.1	0.62	Other	ochrobactin	Ochrobactrum anthropi
BGC0001555.1	0.61	RiPP	colicin V	Escherichia coli chi7122
BGC0000939.1	0.59	Other	aerobactin	Grimontia hollisae
BGC0001870.1	0.57	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0001478.1	0.55	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.54	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.54	Other	desferrioxamine	Streptomyces argillaceus

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP017184.1 - Region 5 - arylpolyene

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Location: 4,388,312 - 4,431,905 nt. (total: 43,594 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.56	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.55	Other	APE Ec	Escherichia coli CFT073
BGC0000837.1	0.30	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001723.1	0.24	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000219.1	0.24	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000873.1	0.24	Other	A-201A	Saccharothrix mutabilis subsp. capreolus
BGC0000194.1	0.24	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0001895.1	0.23	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000235.1	0.23	Polyketide	kiamycin	Streptomyces sp. W007
BGC0000234.1	0.23	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.82	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.81	Other	APE Ec	Escherichia coli CFT073
BGC0000837.1	0.64	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001723.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000219.1	0.57	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000873.1	0.57	Other	A-201A	Saccharothrix mutabilis subsp. capreolus
BGC0000194.1	0.57	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0001895.1	0.56	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000235.1	0.56	Polyketide	kiamycin	Streptomyces sp. W007
BGC0000234.1	0.56	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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