LOCUS       c00029_NZ_SMCQ..       13700 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_SMCQ01000029.1 Longibaculum muris strain DSM 29487 Ga0244711_129,
            whole genome shotgun sequence.
ACCESSION   NZ_SMCQ01000029
VERSION     NZ_SMCQ01000029
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:02:23
            Original ID  :: NZ_SMCQ01000029.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13700
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13700
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2945:3700]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2946..3700
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..13700
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13700
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             368..1921
                     /locus_tag="ctg29_1"
                     /transl_table=11
                     /translation="VVTRYLSSLVDGSFLFGKEKMMEERQFSEQELVRREKLEFLKERG
                     IDPFGQRFDVTHFSEQIKEEFAGKTHEELEEMAVPVKVAGRIMTKRRKGKVCFMHIQDR
                     DGKIQIYVRKDVIGEEDYEVLIKSDIGDIVGIEGTVFVTNTGELSVKATKYIHLTKALR
                     PLPEKYHGLSDVEERYRRRYVDLIMNEESRKIAFARPKIIRSIQNYLDGQGYVEVETPV
                     LNPILGGAAARPFITHHNTLDTDFYLRIATELSLKRLIVGGMDAVYEIGRLFRNEGMDR
                     THNPEFTTIEVYKAFSDLEGMMDLTEGIISNAAKVVCGTYDIEYKGHQLSLAPGFKRIS
                     MTDAIKEKTGIDFASDMTFEEAKALAEERHIEVEPHFGYGHIINAFFEEYVEETIVEPT
                     FVYGHPIEISPLAKKNLDDPRFTQRFELFICGNEYANAFTELNDPIDQYERFANQLKEK
                     ELGNDEANEMDLDYVEALEYGLPPTGGMGMGIDRLVMLLTGQESIQEVILFPQMKPRVK
                     "
     aSDomain        449..1912
                     /aSDomain="TIGR00499"
                     /aSTool="tigrfam"
                     /description="lysS_bact: lysine--tRNA ligase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg29_1_0001"
                     /evalue="2.20E-200"
                     /identifier="TIGR00499"
                     /label="ctg29_1"
                     /locus_tag="ctg29_1"
                     /protein_end="515"
                     /protein_start="27"
                     /score="664.5"
                     /tool="antismash"
                     /translation="SEQELVRREKLEFLKERGIDPFGQRFDVTHFSEQIKEEFAGKTHE
                     ELEEMAVPVKVAGRIMTKRRKGKVCFMHIQDRDGKIQIYVRKDVIGEEDYEVLIKSDIG
                     DIVGIEGTVFVTNTGELSVKATKYIHLTKALRPLPEKYHGLSDVEERYRRRYVDLIMNE
                     ESRKIAFARPKIIRSIQNYLDGQGYVEVETPVLNPILGGAAARPFITHHNTLDTDFYLR
                     IATELSLKRLIVGGMDAVYEIGRLFRNEGMDRTHNPEFTTIEVYKAFSDLEGMMDLTEG
                     IISNAAKVVCGTYDIEYKGHQLSLAPGFKRISMTDAIKEKTGIDFASDMTFEEAKALAE
                     ERHIEVEPHFGYGHIINAFFEEYVEETIVEPTFVYGHPIEISPLAKKNLDDPRFTQRFE
                     LFICGNEYANAFTELNDPIDQYERFANQLKEKELGNDEANEMDLDYVEALEYGLPPTGG
                     MGMGIDRLVMLLTGQESIQEVILFPQMKPR"
     PFAM_domain     608..832
                     /aSDomain="tRNA_anti-codon"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01336.27"
                     /description="OB-fold nucleic acid binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg29_1_0001"
                     /evalue="1.40E-15"
                     /label="ctg29_1"
                     /locus_tag="ctg29_1"
                     /protein_end="155"
                     /protein_start="80"
                     /score="57.1"
                     /tool="antismash"
                     /translation="VKVAGRIMTKRRKGKVCFMHIQDRDGKIQIYVRKDVIGEEDYEVL
                     IKSDIGDIVGIEGTVFVTNTGELSVKATKY"
     PFAM_domain     890..1903
                     /aSDomain="tRNA-synt_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00152.22"
                     /description="tRNA synthetases class II (D, K and N)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg29_1_0002"
                     /evalue="1.60E-78"
                     /label="ctg29_1"
                     /locus_tag="ctg29_1"
                     /protein_end="512"
                     /protein_start="174"
                     /score="264.0"
                     /tool="antismash"
                     /translation="VEERYRRRYVDLIMNEESRKIAFARPKIIRSIQNYLDGQGYVEVE
                     TPVLNPILGGAAARPFITHHNTLDTDFYLRIATELSLKRLIVGGMDAVYEIGRLFRNEG
                     MDRTHNPEFTTIEVYKAFSDLEGMMDLTEGIISNAAKVVCGTYDIEYKGHQLSLAPGFK
                     RISMTDAIKEKTGIDFASDMTFEEAKALAEERHIEVEPHFGYGHIINAFFEEYVEETIV
                     EPTFVYGHPIEISPLAKKNLDDPRFTQRFELFICGNEYANAFTELNDPIDQYERFANQL
                     KEKELGNDEANEMDLDYVEALEYGLPPTGGMGMGIDRLVMLLTGQESIQEVILFPQM"
     CDS             2946..3071
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_2"
                     /sec_met_domain="TIGR04223 (E-value: 2.2e-10, bitscore:
                     31.8, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLITFFLKVVSFMAISGAHSISVLGMYQPKIPDNFNEN"
     aSDomain        2952..3056
                     /aSDomain="TIGR04223"
                     /aSTool="tigrfam"
                     /description="quorum_AgrD: cyclic lactone autoinducer
                     peptide"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg29_2_0002"
                     /evalue="2.70E-08"
                     /identifier="TIGR04223"
                     /label="ctg29_2"
                     /locus_tag="ctg29_2"
                     /protein_end="37"
                     /protein_start="2"
                     /score="31.8"
                     /tool="antismash"
                     /translation="KLLITFFLKVVSFMAISGAHSISVLGMYQPKIPDN"
     CDS             3146..3700
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_3"
                     /sec_met_domain="AgrB (E-value: 9.8e-27, bitscore: 84.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLSKKILTELINKKYIEEDKYNFYDYGMKVLIMNLLPILLVLTI
                     SIIVDDITYGIFFLLSFTPIRINLGGYHCSCVKKCLISFVMLFIITLFMRKLDIHILIK
                     IVGFIAIVIFWFVTPLTNDFLGNYKEIYTKSKQHIKTVCVILFFILHFINNHSVIEGIS
                     MACILNVFLYFLGSLKKKKLI"
     PFAM_domain     3155..3658
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg29_3_0003"
                     /evalue="3.50E-24"
                     /label="ctg29_3"
                     /locus_tag="ctg29_3"
                     /protein_end="171"
                     /protein_start="3"
                     /score="85.3"
                     /tool="antismash"
                     /translation="SKKILTELINKKYIEEDKYNFYDYGMKVLIMNLLPILLVLTISII
                     VDDITYGIFFLLSFTPIRINLGGYHCSCVKKCLISFVMLFIITLFMRKLDIHILIKIVG
                     FIAIVIFWFVTPLTNDFLGNYKEIYTKSKQHIKTVCVILFFILHFINNHSVIEGISMAC
                     ILNVF"
     CDS             3791..4486
                     /locus_tag="ctg29_4"
                     /transl_table=11
                     /translation="LKFKIIDDDSNFSVQLKYDLYVHFKDYVNIEDIEILTNDFYKINL
                     IDTDVIFIDIDLEKFDGIELSTQIRNIYPAIIIIFISSHENLVFNTLVVRPFQFIRKSK
                     YNEDKYIVFRLLKKHLDMYYRNIILTIKGRMVKINITKIIYCISLGHELTIHTESRDYV
                     IAKSILQFLNLLDSTNFVQIQRNVIINLSYSKEVTKKFVLLSPNYKFNIGRKYQKNLLE
                     YYKKYLLTK"
     PFAM_domain     3803..4099
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg29_4_0004"
                     /evalue="2.60E-08"
                     /label="ctg29_4"
                     /locus_tag="ctg29_4"
                     /protein_end="103"
                     /protein_start="4"
                     /score="34.1"
                     /tool="antismash"
                     /translation="IIDDDSNFSVQLKYDLYVHFKDYVNIEDIEILTNDFYKINLIDTD
                     VIFIDIDLEKFDGIELSTQIRNIYPAIIIIFISSHENLVFNTLVVRPFQFIRKS"
     PFAM_domain     4190..4459
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg29_4_0005"
                     /evalue="1.10E-13"
                     /label="ctg29_4"
                     /locus_tag="ctg29_4"
                     /protein_end="223"
                     /protein_start="133"
                     /score="51.3"
                     /tool="antismash"
                     /translation="RMVKINITKIIYCISLGHELTIHTESRDYVIAKSILQFLNLLDST
                     NFVQIQRNVIINLSYSKEVTKKFVLLSPNYKFNIGRKYQKNLLEY"
     CDS             4746..4991
                     /locus_tag="ctg29_5"
                     /transl_table=11
                     /translation="MGRLLKYAYPIFFSVHLKDKSKVTFEAMLGTNRKSFIEAIQFLES
                     KNVVFKYEYELLDKIKDMNTNIWESIEEIIAFKLKK"
     CDS             complement(5405..6622)
                     /locus_tag="ctg29_6"
                     /transl_table=11
                     /translation="MVVFNYLINFIEGFILSSFIAFYFDLKDKIKYISIVSLICFSLIS
                     ISNFINEFDHFLLYILIIALLISLWITKKDKNFEDIIICFIAGMMLLIANLISLSCTSL
                     IFNISTTDIYDNQQLFVFAIILSKLIFTFIAIITCAFKLKTNTKLPMKYWWIILILGLS
                     IIFVLAILIESLLSNFMSSNMILILMIAIIVISFLFLVIFRKIQIENAEKIKLALEIQK
                     NKYNTENYNKIVAISNQITEAEHRMMYVLMQLRTCIDNMDYENASIITDQYIKKVKSFN
                     SMITTNNPYFDFIISRKINELIFQDIYVKKTIFISQNDIYNNKNFCDLILKIIYIFEIN
                     LDNSKELNLGISQESNFVLIEVIGRLTTNNFKISDEINNLIKLFNADFTLNNTKEIVTL
                     KLIIEI"
     CDS             complement(6616..7314)
                     /locus_tag="ctg29_7"
                     /transl_table=11
                     /translation="MNVAIVDDDIIFSRTLKKLIESFLNKIFNDLKIELINDNFYNRIK
                     DKPYDLIFLDIDLKKSNGINIGKNTLLWENQPIIIFVSARNELVFSSLSVRPFYFVRKS
                     NLKNDLTTMFVLLKKYFNEQMSFFTFEFHGRITNIYFKDICIIESKGHNIIIKTKKGEY
                     ICRASMKNILETLGEKNIVQIQKAYAVNIDYIKEINKGIVYLKNNEQYNIGRKFKKTVV
                     QKYKERFLKW"
     PFAM_domain     complement(6643..6912)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg29_7_0007"
                     /evalue="4.60E-16"
                     /label="ctg29_7"
                     /locus_tag="ctg29_7"
                     /protein_end="224"
                     /protein_start="134"
                     /score="58.9"
                     /tool="antismash"
                     /translation="RITNIYFKDICIIESKGHNIIIKTKKGEYICRASMKNILETLGEK
                     NIVQIQKAYAVNIDYIKEINKGIVYLKNNEQYNIGRKFKKTVVQK"
     PFAM_domain     complement(6976..7308)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg29_7_0006"
                     /evalue="1.30E-08"
                     /label="ctg29_7"
                     /locus_tag="ctg29_7"
                     /protein_end="113"
                     /protein_start="2"
                     /score="35.0"
                     /tool="antismash"
                     /translation="VAIVDDDIIFSRTLKKLIESFLNKIFNDLKIELINDNFYNRIKDK
                     PYDLIFLDIDLKKSNGINIGKNTLLWENQPIIIFVSARNELVFSSLSVRPFYFVRKSNL
                     KNDLTTM"
     CDS             7995..8315
                     /locus_tag="ctg29_8"
                     /transl_table=11
                     /translation="MDKEYFNIVKYDQIHERINSGKKFILVIGRKECPYCKDLIQKIKK
                     DINTTKKYIYYFEMGKGDMKLKDKLIDELGEFNYAPHVILISRKNVLLGKHTNINVVSH
                     NG"
     CDS             8405..8560
                     /locus_tag="ctg29_9"
                     /transl_table=11
                     /translation="MKKKYNVMNRYNYYGYNLLFMIVNTIMIIILYNQGYLGMVTEDFS
                     EILKSF"
     CDS             8578..8874
                     /locus_tag="ctg29_10"
                     /transl_table=11
                     /translation="MHIIIILLTIIPFTLYYLKKKNRDELPSTISIEIITYSCIFIPII
                     IILTVIELYLTLNIPGSAWLVAFVMLFSHLFIFHYIYVIQLYKYVDGVFSLGK"
     CDS             9518..10093
                     /locus_tag="ctg29_11"
                     /transl_table=11
                     /translation="LFFIFSFIECIAYGKIILEKQLRGCVACMKKKIIIFSVVFICIVS
                     IAFIFFTRKDDDIYTPTIKDIDNFTIENNNRYIILYSSEDNKYYLGKVSTYTLDDNLYY
                     LGDTACNFKKVNNNLIVISNSEQVVYSSGDYDFLPDKVYDIKTMGNLMISYDSKNHDMQ
                     ILKRNSEAKCILKFKYYNNFIPVDLIET"
     CDS             10499..10798
                     /locus_tag="ctg29_12"
                     /transl_table=11
                     /translation="MDLDYVEALEYGLPPTGEMGMGIDRLVMLLTGQESIQEVILFSQI
                     SREKSRILIRVLLFLYKNSECLIQSVSFFFISIHIYLISKYLDRFDSLYHKDNE"
     PFAM_domain     10508..10630
                     /aSDomain="tRNA-synt_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00152.22"
                     /description="tRNA synthetases class II (D, K and N)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg29_12_0008"
                     /evalue="5.60E-13"
                     /label="ctg29_12"
                     /locus_tag="ctg29_12"
                     /protein_end="44"
                     /protein_start="3"
                     /score="48.7"
                     /tool="antismash"
                     /translation="DYVEALEYGLPPTGEMGMGIDRLVMLLTGQESIQEVILFSQ"
     CDS             complement(10742..12478)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 144.2; E-value:
                     8.6e-44)"
                     /gene_kind="transport"
                     /locus_tag="ctg29_13"
                     /transl_table=11
                     /translation="MIRLEDINIVFDRPLFVHQNIEIKDHCLTLIAGESGCGKTTLLYQ
                     IGLINYSEKNAKYWINDIDITSFSMHKKTLFRRYNIAFVFQNYMLYEHFNVYENLCYYA
                     ALSNKSLNEEDAREYLNKVHLDVLLDKALYTLSGGQKQRLAIACALIKDAPILILDEPT
                     SALDEKNAISIFQVLKEISQEKTVIVTSHNQIAYDYCDEIIEIKDGNIHKIKESHAKNQ
                     ESVIHQKNSSHISWQTYRFYMKRQFHFSRKMKYLLILAHLVILLFCFGTVYLTDQSIQD
                     NLNMISSKDPGWMYVEGIKKDELSSNTIMSSYPFYDVSLFILNDSYPVIPYYPEENIAS
                     KIWFRMDVTDNDGFYFSNSLYTSIKYLVAPTNEMSFLNISNGKEVSLFYKGILLQGVAS
                     ELIDSKKFIYMPQELIENQLNPQQVNGYVVFCNSYQNYVQTKETLEKSAYKVITYHQFD
                     SIAKYVERLHDIQQNLIIGILVLGCIILMIMYRSYIQSREKELSLLKCMGLTTLNISAL
                     VCFELILMNIIGLFIVFILTNLFIQDFYQYIFLVETAILLVNILLIVFMIKRIKPVKVF
                     RN"
     PFAM_domain     complement(11987..12418)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg29_13_0009"
                     /evalue="2.10E-22"
                     /label="ctg29_13"
                     /locus_tag="ctg29_13"
                     /protein_end="164"
                     /protein_start="20"
                     /score="80.2"
                     /tool="antismash"
                     /translation="IEIKDHCLTLIAGESGCGKTTLLYQIGLINYSEKNAKYWINDIDI
                     TSFSMHKKTLFRRYNIAFVFQNYMLYEHFNVYENLCYYAALSNKSLNEEDAREYLNKVH
                     LDVLLDKALYTLSGGQKQRLAIACALIKDAPILILDEPTS"
ORIGIN
        1 atgaggttat atcataacat gaagttttga atatgtcctg catgcaggac atattcaact
       61 ttgatacatt gagacaatat catatttgaa tcagagaata aaagaaaaac caagttctta
      121 acttgacaag aacttggttt atttatataa tacatgcgta tagaaaaaag gctgtgaata
      181 gacaagtaat tgttatgatg tatgactaga gagtcctgat ggtggaaatg gatgataata
      241 ttaacaatga ataaagacta ggagctgtat tttggatcaa aggtgataaa ataacgtgtg
      301 ccgcgttaca ggctagactc tgataggagt tgaaaagatt actatagtga tatagtaatg
      361 aattagggtg gtaacacgat atctctcgtc ccttgtggat gggagttttt tatttggaaa
      421 ggagaaaatg atggaagaaa gacaatttag tgaacaagaa ttagtaagac gtgaaaagtt
      481 agagttttta aaagaaagag gaattgatcc ttttggacaa agatttgatg tgactcattt
      541 ttctgaacaa attaaagaag aatttgctgg gaaaacacat gaagaattag aagaaatggc
      601 agtacctgtt aaagtggctg gaagaattat gacaaaacgt cgtaaaggaa aagtctgctt
      661 tatgcatatt caagatagag atggaaagat tcaaatctat gtaagaaaag atgttattgg
      721 tgaagaagat tatgaagttt taatcaagag tgatattggt gatattgttg gtattgaagg
      781 aactgttttt gttacaaata caggtgaact ttcagttaaa gcaacaaaat atattcactt
      841 aacaaaagca ttacgtcctt tacctgaaaa atatcatggt ttaagtgatg ttgaagaaag
      901 atatagaaga agatatgttg atttaattat gaatgaagaa tcaagaaaga ttgcttttgc
      961 aagacctaaa attattcgtt caattcaaaa ttatttagat ggtcaaggat atgttgaagt
     1021 agaaactcca gttttaaatc ctatcttagg gggagctgct gctagaccat ttataactca
     1081 tcataatact ttggatactg atttctattt aagaattgct actgaattat ctttaaagag
     1141 attaattgtt ggtggtatgg atgcggttta tgaaattgga agattgttta gaaatgaagg
     1201 aatggataga acacataatc ctgaatttac aacaattgaa gtttacaaag cttttagtga
     1261 tcttgaaggg atgatggatt taactgaagg tattatttct aatgctgcaa aggttgtttg
     1321 tggaacttat gatattgaat ataaaggaca tcaattatca ttagctcctg gatttaaacg
     1381 tatttctatg actgatgcaa ttaaagaaaa aactggtatt gattttgcta gtgatatgac
     1441 ttttgaagaa gcaaaagcat tagctgaaga aagacatatt gaagtagaac ctcactttgg
     1501 ttatggtcat attattaatg ctttctttga agaatatgta gaagaaacaa ttgttgaacc
     1561 tacttttgta tatggacatc caattgaaat ctctccactt gcaaagaaaa acttagatga
     1621 tccacgtttt acacaacgtt ttgaattatt tatttgtggt aatgaatatg ctaatgcatt
     1681 tactgaatta aatgatccta ttgatcaata tgaaagattt gctaatcaat taaaagaaaa
     1741 agaattaggt aatgatgaag caaatgaaat ggatttagat tatgtagaag cattagaata
     1801 tggtttacca ccaacaggtg gaatgggtat gggaattgat agattagtta tgttattaac
     1861 tggtcaagaa tctattcaag aggtaattct ctttccgcaa atgaagccac gtgtgaaata
     1921 attaaacata gtaaaagagc tctttctcat tttaaattat gagcgtaaaa agaaaagagg
     1981 aaatgatttt attgataaat agtcaatatt ttcaactcct ctttttagtt taactatttt
     2041 ttgctctaaa tagagtaaaa aacaaaaaag tatatatagg ttttaaaaat atgaatatgt
     2101 gtttctttaa tattgtttca tgaattttat tatttttgtt catataaatt tgaagaggac
     2161 ctttactaat gaaaaagtaa agtaacaaat aattagtgaa tcagttagca aaggtaagca
     2221 tgctttgtct aatcactgta aatgatatgg cgattactaa cgactgtgag taaacttaaa
     2281 ataatgttaa aagattaata tccaataaaa gacattctaa aagaaagtat cagaaaggta
     2341 ggtattaaag ttgaataaag attatatgta tttttataat aaagtatcaa gcgctgatat
     2401 atctccaaca gcaagaacgg tctacagagc attgctaaga tatgctaata gaaaaactag
     2461 tcatgttttc tctctattaa caccatagca aaagatacag gcttaagtaa acgtactatt
     2521 attagacaac tggcagtttt tgaaaaagaa gatttaatac taaaaataca tagaactcga
     2581 gaaaacaatg gaagtacaag taatatgtat ttttttaatt agattttttg ttgggataat
     2641 tgtaaatata tcatgacact accttaatgt catattgtca cctctgtaac tatttttata
     2701 actaggacat attacagaag gagaaacatt atataagata aaaatatatg tatgttgatt
     2761 tactgggttt aaaaaatatg ttagttgtga caaatagatg ttagttatga caaaattata
     2821 aacatattat aaaaaaaata taaaatgtag aatataaagg agataacaaa tataaaatat
     2881 agaatgaaca ttaattaaaa caaatatttg cagtttttat taaaaaatga ggaaggtgaa
     2941 atattatgaa aaaattatta ataacttttt ttctaaaggt tgtttctttt atggcaatat
     3001 caggagcaca ttcaatttct gttttaggaa tgtatcaacc aaaaatacct gataatttta
     3061 atgaaaatta atgaagtcag tttaatatat ggtgtgttaa caatgtatta ttaaataaga
     3121 taagtaattt taaagagggg aagacatgaa tttgagcaaa aaaatattaa cagaattaat
     3181 aaataaaaag tatattgaag aagataaata taatttttat gattatggaa tgaaagtgtt
     3241 aataatgaat ttattaccaa tactgttagt tttaactata tctattatag ttgacgatat
     3301 tacatatgga atattttttt tactatcatt tacgcctata agaattaatt taggtggtta
     3361 tcattgttca tgtgtaaaaa aatgtttaat ttcatttgtt atgctcttta taattactct
     3421 ttttatgaga aaattggata tacatatact gataaaaata gtaggattta ttgctattgt
     3481 catattttgg tttgttactc ctttaactaa tgatttctta ggaaattata aagaaatata
     3541 tacaaaatct aaacaacaca taaaaacagt atgtgtaata ttatttttta ttttacattt
     3601 cataaataat catagtgtta ttgaaggtat ttcaatggca tgtatcttaa atgtttttct
     3661 ctattttcta ggaagcttaa aaaagaagaa attaatataa aggatcataa tcaatcacaa
     3721 tagaccattg aagatatgga taattaaact taaatacaat aacttttaaa aataggagga
     3781 tataagaaaa ttgaaattta aaattattga tgatgattcg aatttttctg tacaattaaa
     3841 atatgattta tatgttcact ttaaagatta tgttaatatt gaagatatag aaattttaac
     3901 aaatgatttt tataaaatta atttaataga tacagatgtt atttttatag atattgacct
     3961 agaaaagttt gatggaatag aattatctac acaaattaga aacatatacc cagcaatcat
     4021 tattatattt atttcttcac atgaaaattt agtttttaac actcttgttg taagaccatt
     4081 tcaatttatt agaaaatcaa aatacaacga agataaatat atagtattta gattattaaa
     4141 aaaacattta gatatgtact atagaaatat tattttaaca ataaaaggga gaatggtaaa
     4201 aattaatata acaaaaataa tatactgtat ttcactggga catgaactta caatacatac
     4261 agaaagcaga gattatgtta ttgctaaatc aatattacaa tttctaaact tattagattc
     4321 aacaaatttt gtacaaattc aaagaaatgt aattattaat ttaagttatt caaaagaagt
     4381 caccaaaaaa tttgtactgc tttcaccaaa ttataagttc aatattggca gaaaatatca
     4441 aaaaaattta ttagaatatt ataaaaaata tttattaaca aaataataat aatcatgaat
     4501 atcatagaat aataaaaaat aaatataatt aagatatatt taaaaagtct tatttgatat
     4561 atcagtaatg gagagtaata ttatgaaaat ttatgtagga aaaaaaatct aatcattggg
     4621 acattgaatc aaataaaatt agtgtctatg acacgaaaga agtaatcttt acaagaccag
     4681 agttagttaa ttcagtttat atagatgata ttgactatat tcatgtctat tggaaaaata
     4741 tattaatggg gcgtttgttg aaatatgctt atccaatctt cttttcagta catttaaaag
     4801 ataaaagtaa ggtgacattt gaggcaatgc taggtacaaa tagaaaaagt tttattgaag
     4861 caatacaatt cttagaatca aaaaatgttg tttttaaata tgaatatgaa ttgcttgata
     4921 aaattaaaga tatgaataca aatatatggg aaagtattga agaaattatt gcttttaaat
     4981 taaaaaaata gatgtttttg aagacaatgc aatttttaga aatgatataa gtagttttag
     5041 atggagctat agaacttatg atattatcgt taaatgagac aaaggaaaag caataatttt
     5101 cattaatgtc tgggaaatta tcttcaatgt ttataaacct aattatagaa aacgaaacat
     5161 attttttaaa tatcttaggg ataatgataa atgtgcaaat atctatacaa tactagataa
     5221 ttatttatta gaaagcataa tctatatctc agtattaaag tgcatcgtaa aaagataaat
     5281 aaaattcata tatttttatg tgataatcac atggttactg tttactaagc atacaaagtg
     5341 ttatcagcac aacagagtaa tattattaat aataatttca attactagga tattttattt
     5401 tgatttatat ttcaataatc aattttagag taacaatttc ttttgtattg tttaaagtaa
     5461 agtcagcatt gaataactta attaaattat ttatttcatc agaaatttta aaattattag
     5521 ttgttaatct tcctataacc tctattagaa caaaattact ttcttgactt ataccaaggt
     5581 ttagttcttt gctattatct agattgattt cgaatatata tataatttta agtattagat
     5641 cacaaaaatt tttattatta tatatatcat tttgagatat aaatattgtt tttttgacat
     5701 atatatcttg aaaaataagt tcattaattt ttctgctaat tataaaatca aagtatggat
     5761 tatttgttgt aatcatagaa ttaaacgatt ttactttttt tatatattga tcagttataa
     5821 ttgatgcatt ttcatagtcc atgttatcga tgcaagttct tagctgcatt aaaacataca
     5881 tcattctatg ttcagcttca gtaatttgat tagatattgc aactatttta ttatagttct
     5941 ctgtattata tttattcttt tgaatttcta atgctaactt tattttttcg gcattttcta
     6001 tttgtatttt tctaaaaatt actaagaata aaaatgatat tactataata gcaatcatta
     6061 atataagaat catatttgaa gacataaaat tgcttaacag actttctatg agaattgcta
     6121 aaacaaaaat aatagataat cctaagatca aaattatcca ccaatatttc ataggtaatt
     6181 tagtatttgt ttttaattta aatgcacaag ttataattgc aataaatgta aaaatgagtt
     6241 tggataaaat tatagcaaat acaaataact gttggttgtc ataaatgtct gttgtactaa
     6301 tattaaagat taaagatgta catgataatg aaatcaaatt tgcaattaga agcatcattc
     6361 ctgcgatgaa acaaataatt atatcttcaa aatttttatc tttttttgta atccataaag
     6421 atattaatag tgcaattata agtatgtata gtaaaaaatg atcaaattca ttaataaaat
     6481 ttgatatact aatgagtgaa aaacaaatta aagaaacaat agagatatat tttattttat
     6541 cttttaagtc aaaataaaac gcaataaaag aacttaatat gaaaccttct ataaaattaa
     6601 tcaaataatt aaatactacc attttaaaaa tctttcctta tatttttgaa caacagtttt
     6661 tttaaatttt cttccaatgt tatattgttc attatttttt agatatacta tgcctttatt
     6721 aatttcttta atatagtcaa tattaacagc atatgctttt tggatttgaa caatattttt
     6781 ttcccctaaa gtttctaaaa tatttttcat tgatgctctg caaatatatt cgcccttttt
     6841 agtttttata ataatgttat gacctttaga ttctataatg catatatctt taaaataaat
     6901 attagttatt ctaccatgaa attcaaatgt aaaaaaagac atttgctcat taaaatattt
     6961 ttttaacaac acaaacattg tagttaagtc attttttaaa tttgattttc tgacgaaata
     7021 gaatggtctg acagatagag aggagaatac aagttcgttt ctagcagaaa caaaaattat
     7081 aataggctga ttttcccata acagtgtgtt ttttccaata ttaatgccat ttgatttttt
     7141 taaatcaata tctaaaaaaa tcaaatcata aggtttatct ttaatgcgat tatagaaatt
     7201 atcatttata agttcaattt ttaaatcatt gaatatttta tttaggaatg attcaattaa
     7261 ttttttcaga gttctagaaa atataatatc atcgtctaca atagcaacat tcattgtaaa
     7321 aatcaccttc ttttttttaa ttatagcata tttagattat aaaaaaaatt gttaaagaaa
     7381 ccaaagattt acattgatat atttaaatat aattatattt tcattaatga ttataatatt
     7441 gtttcatttt ataaacgaat taaaattata atgttttcta cgcaaaaaac aggtgttcta
     7501 cgcattaatt atatatattt tttttcaaag gaattatact tattatagat ataagaagta
     7561 taattctatt ttaaataatt ttgaggagga gataaaaatg gttattatat taataataaa
     7621 aaattgaatc aaaccatttt gattatctaa atttaactta gaatttataa atgaaaatta
     7681 tgtataaaca ttctattaat tttttgatta aataatgtag attagtataa tattataaag
     7741 aagaacatag atattaattt aaatattatt gattatgtta gatatctcaa aagtgtttct
     7801 ctttctcatt taaatatata agttatgtta tatattttat aaataactat atttatttat
     7861 aataatctaa gttaagattc taaattttaa tacagattaa aaaaagaata attaggtgat
     7921 tttatgatta acagaaaaaa gtaatctgta tcagcattgt ttttttaata atactaatga
     7981 ttggactaaa aaatatggat aaagaatatt ttaatatagt caaatatgat caaattcatg
     8041 aaagaataaa ttcagggaaa aaatttatat tagttatagg aaggaaagag tgcccatatt
     8101 gcaaagattt gatacaaaaa ataaaaaagg atattaatac tactaaaaaa tacatatatt
     8161 attttgaaat gggaaaaggg gatatgaaat taaaagataa gttaattgat gaacttggtg
     8221 aatttaatta tgcaccgcat gtaatattga tttcaagaaa aaatgtactg cttgggaaac
     8281 acacgaatat aaacgtagtg tcccataacg gctaagttta atacacttaa taacactaaa
     8341 aatattaagt gatctacacc aaatataata caaaattcat attatataaa aaggagagat
     8401 ttttatgaag aaaaaatata atgttatgaa taggtacaat tattatggtt ataatctatt
     8461 atttatgatt gtaaatacga ttatgattat aattttgtat aatcaggggt atttggggat
     8521 ggtcacagaa gatttttctg aaatattaaa atctttttag ggttctattt tgatcctatg
     8581 catattatta ttattctttt aacaattatt ccattcactt tgtattattt aaaaaagaaa
     8641 aacagagatg aattgccatc aacaatctca attgaaataa taacatatag ttgcatattt
     8701 atacctatta tcattatttt aactgtaatt gaattatatt taactttgaa tattccagga
     8761 agtgcctggt tagttgcatt tgtaatgtta tttagtcatc tatttatttt tcattatata
     8821 tatgtgatac aactttataa atatgtagat ggtgtgttta gtttaggtaa ataaaaaact
     8881 tatattatta gattattata atttcaatga aataaatgct taattcatgt gtaagtagta
     8941 attatcaaaa aatatatact aatgtgatat attaattaat tacgaggttt gtttatggtg
     9001 agtattctga acttatcagt tatgcttttt tattagtaat gaaagttgtt tataagtata
     9061 ggtggcatac attttataaa ttatcaatat attcaacaat atttttctac ttttctcata
     9121 tatatatggg tatataaaaa ctcctttctt aaaaattggt ttgaagactg attgtttctt
     9181 attattctct tgaaagagca ttataaaaac atgtctcttt tcgtggttga ctatttagaa
     9241 agtttggcga tggactagat agtcttttcg tttgaatata attgtaaaac gtgctaatac
     9301 aaatagcaac ttcatcatca ataagatcac tgcagtgcaa cttttggtag ttaatagtta
     9361 ccttattttt tgttgattaa aataatacga tatctttgaa gattttttaa tatctagatg
     9421 acagaaatca atatgctatt attaggataa ggcatacctt gtcctaataa tctttaattc
     9481 cattttttta taatacacgg attagaataa tatttaattg tttttcattt tttcttttat
     9541 tgagtgtata gcctatggta aaattatatt agaaaaacag ttgagaggat gtgtcgcttg
     9601 tatgaagaaa aaaataataa tttttagtgt tgtattcatt tgtatagttt ctattgcttt
     9661 tatctttttt acaagaaaag atgatgatat atatactcca actatcaagg atatcgataa
     9721 cttcacaatt gaaaataaca atagatatat catactttat agtagtgaag acaataaata
     9781 ttatttaggt aaagtatcaa cttatacact tgatgataac ttatactatt taggagatac
     9841 tgcttgtaat tttaaaaaag tgaataataa tcttattgtt ataagtaata gcgagcaagt
     9901 tgtttattct agtggagatt acgatttttt acctgataaa gtatatgata tcaaaacaat
     9961 gggaaatttg atgatatctt atgatagtaa aaatcatgat atgcaaatac ttaaaagaaa
    10021 ttctgaagca aaatgtattt taaaatttaa atattataat aattttattc ctgttgattt
    10081 aattgaaaca taggaaatat aaataaaatt tgtataagtg taaaattact atatatcagt
    10141 aactttattt tttatttttg taaagaaata atttaatttt aattttatag gatataagtg
    10201 tcaaaaagtg tcaattttag atttgatgtg ttataatttg ggaacataaa tatgaataat
    10261 gttgataaag taatgtttaa aaaatagtaa ttttatcatt agaagttttg aatattacta
    10321 cacatgaaat aacgtaataa atagggataa aattaatatt ttgaagatgt cactggcata
    10381 cattttggca tacaaaatga aatcaataga gataaaatta gtgtataaac acttgtttta
    10441 gatatctaat aacttagaaa aacacataaa aatgtatata tataatgaat gaattgaaat
    10501 ggatttagat tatgtagaag cattagaata tggtttacca ccaacaggtg aaatgggtat
    10561 gggaattgat agacttgtta tgttattaac tggtcaagaa agtatccaag aagttatctt
    10621 gttttcgcaa attagtcgtg aaaaaagcag aattcttata agagttctac tttttttata
    10681 taaaaatagt gaatgtttga tacaaagtgt atcttttttt tttatctcca ttcatatcta
    10741 tttaatttct aaataccttg accggtttga ttctctttat cataaagaca atgagtaaga
    10801 tattaacaag taaaatagct gtttcaacca aaaagatata ttgataaaag tcttgaataa
    10861 acagattcgt caagataaac acaataaaca atccaataat attcatcaat atcaattcaa
    10921 aacatacaag cgcagaaata ttaagcgtag ttaatcccat gcatttaagt agtgataatt
    10981 ctttttctct actttgaata tatgaacgat acataatcat aagaataatg catcctaaaa
    11041 cgagaattcc aataataaga ttctgttgaa tatcatgcaa tctttctaca tattttgcta
    11101 tgctgtcaaa ttgatggtat gtgataactt tataagctga tttttctaaa gtctcttttg
    11161 tttggacata attctgatag gaattacaaa acacgacata tccattgact tgctgaggat
    11221 tcaattgatt ttcaattaat tcttgaggca tataaataaa cttcttagaa tcaatcagct
    11281 cgcttgcaac tccctgcaac aatattcctt tataaaaaag agaaacttct tttccgtttg
    11341 atatattcaa aaaagacatt tcgtttgttg gtgcgacaag atacttaata ctcgtatata
    11401 gcgagttact aaaataaaat ccatcattgt ctgtaacatc cattctaaac caaatcttac
    11461 ttgcaatatt ttcctcagga tagtacggaa taactggata cgaatcattt aatataaaca
    11521 atgaaacatc ataaaacgga taagatgaca tgattgtatt tgatgataat tcatccttct
    11581 tgataccttc aacatacatc cagccaggat cctttgaaga aatcatattc aggttatcct
    11641 gaatagattg atccgttaaa tagactgttc caaaacaaaa cagcagaata actaaatgag
    11701 ctaatatcaa taaatatttc atctttcttg aaaaatgaaa ttgtcttttc atataaaaac
    11761 gatatgtctg ccatgaaata tgtgatgaat ttttttgatg aataacactt tcttgatttt
    11821 tggcatgaga ttcttttatt ttatgaatat taccatcctt tatttcaata atttcatcac
    11881 aatagtcata agctatttga ttatgacttg tcacaataac cgttttttct tggctgattt
    11941 ccttaagaac ctgaaatatt gaaatggcat ttttctcgtc caatgcactg gttggttcat
    12001 ctaatattaa gattggtgca tctttgataa gagcacatgc tatggctaat cgctgttttt
    12061 gtccaccaga aagtgtatag agtgccttat ccagcaagac atcaagatga accttattta
    12121 aatattctct ggcatcttct tcattcaatg atttgtttga caaagctgca taatagcata
    12181 aattttcata cacattgaaa tgctcatata acatatagtt ttgaaaaaca aaagcgatat
    12241 tatatcttct aaaaagtgtt ttcttatgca tagaaaatga tgttatatct atatcattaa
    12301 tccaatattt tgcatttttt tctgagtagt taataaggcc tatctgataa agaagcgttg
    12361 tcttaccaca accactttca ccagctatca atgtcaaaca atgatctttg atttctatat
    12421 tttgatgaac aaacaatggt ctatcaaaga caatattgat atcttcaagt ctaatcattt
    12481 gacaacacct cccataacat tggtacaact agctgtataa tgaatgcaac tgtaaagatt
    12541 accaacaccg aattaaagtc tatgatatat ggctgataat aaacatatgc agatatgagt
    12601 acgactaccc aaagcatcat gtaagaaatt atcgctagca aaagagcatt aatgaaatat
    12661 ttttggatct taatctttaa tatatccttc ttttgaagat aacctatgct tcttaaccac
    12721 tggttgaaat ttttttcatc ctttcccttg ataaaatgaa taattccata aatgaatgtt
    12781 acaaaaataa tcgaagctat acttataaaa taaagtgttg tttttgtatt cttcatagat
    12841 tcacctatca attgataatc attatatttc caatcaactg tcagtccttt tgactccaat
    12901 tcatcaacaa ccttttcaat gtgttcagtt ttatcaacct caacagtgta tgcatttggt
    12961 tgccatggtg tatagacttc aaccaaatca gcatcttcca atgaatgagt ttccacatat
    13021 ccttctgcac tatccctcaa atagacagat tttccttttg taggcataca cgattgggct
    13081 atcttttcta gcaattgatc attcatataa aaagttgcat cctgttctgt cagtgctcct
    13141 tctaaatcat gttcaaccac acctaatata ggtaaaacta attctttaga agtacattca
    13201 atataatttg ccggaagaaa atcgtcgtcg cttgtttcta taccacttgg agtacttccg
    13261 gaaaattgca tctttccaga aacatcatac ataggtattg caatattcat tttaatagat
    13321 gcgtctttta aattatctat cgttaagcca catctgatca taaattgctt cgttaaataa
    13381 atgccatctt cttcatgatt tcgaaaggat tcagatatat atttctcttt ttcttgatta
    13441 ttcattttat caataaataa tgtaaaaaaa ttcgaattgc tttccttcaa ttctttatca
    13501 atagtatttt gataatcata aatgatttga ttatctttaa taatttgcat ggatggataa
    13561 ctttttaata acctctcatc aatataacta tgcaaaataa tttttgggga cattgatgca
    13621 atgtttggta tattttgaat cgtagcgagt tctgatgatg ttataggaaa atatgttgca
    13681 ttttccatat ttccattaaa
//
