GCF_013122135.1_ASM1312213v1_genomic - 8 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP053391.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	siderophore	1,591,777	1,610,194	acinetoferrin	NRP	40%
Region 2	betalactone	1,881,807	1,906,316
Region 3	redox-cofactor	2,024,325	2,046,515	lankacidin C	NRP + Polyketide	13%
Region 4	betalactone	2,406,754	2,435,834	fengycin	NRP	13%
Region 5	RiPP-like	2,598,209	2,609,072
Region 6	arylpolyene	3,056,746	3,096,253	berninamycin A	RiPP	26%
Region 7	arylpolyene	3,374,435	3,418,037	APE Vf	Other	45%
Region 8	NRPS,hserlactone	3,790,217	3,834,176

NZ_CP053391.1 - Region 1 - siderophore

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Location: 1,591,777 - 1,610,194 nt. (total: 18,418 nt) Show pHMM detection rules used

siderophore: IucA_IucC

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000940.1	0.31	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001478.1	0.31	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0001572.1	0.27	Other	desferrioxamine E	Pantoea agglomerans
BGC0000946.1	0.23	Other	vibrioferrin	Vibrio parahaemolyticus
BGC0000295.1	0.22	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0000941.1	0.21	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.21	Other	desferrioxamine	Streptomyces argillaceus
BGC0000942.1	0.21	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001499.1	0.20	Other	aerobactin	Pantoea ananatis
BGC0001498.1	0.19	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000940.1	0.64	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001478.1	0.64	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0001572.1	0.60	Other	desferrioxamine E	Pantoea agglomerans
BGC0000946.1	0.56	Other	vibrioferrin	Vibrio parahaemolyticus
BGC0000295.1	0.54	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0000941.1	0.54	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.54	Other	desferrioxamine	Streptomyces argillaceus
BGC0000942.1	0.53	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001499.1	0.52	Other	aerobactin	Pantoea ananatis
BGC0001498.1	0.51	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338

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NZ_CP053391.1 - Region 2 - betalactone

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Location: 1,881,807 - 1,906,316 nt. (total: 24,510 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.1	0.25	Other	showdomycin	Streptomyces showdoensis
BGC0001197.1	0.22	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000679.1	0.22	Terpene	diazepinomicin	Micromonospora sp. M42
BGC0001465.1	0.22	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0002034.1	0.22	Other	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0002000.1	0.21	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002008.1	0.21	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.20	Other	APE Ec	Escherichia coli CFT073
BGC0001848.1	0.20	Other	diazaquinomycin H, diazaquinomycin J	Micromonospora sp. B006
BGC0000258.1	0.20	Polyketide	prodigiosin	Serratia sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.1	0.58	Other	showdomycin	Streptomyces showdoensis
BGC0001197.1	0.55	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000679.1	0.55	Terpene	diazepinomicin	Micromonospora sp. M42
BGC0001465.1	0.55	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0002034.1	0.55	Other	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0002000.1	0.53	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002008.1	0.53	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.53	Other	APE Ec	Escherichia coli CFT073
BGC0001848.1	0.53	Other	diazaquinomycin H, diazaquinomycin J	Micromonospora sp. B006
BGC0000258.1	0.52	Polyketide	prodigiosin	Serratia sp.

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NZ_CP053391.1 - Region 3 - redox-cofactor

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Location: 2,024,325 - 2,046,515 nt. (total: 22,191 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

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Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000294.1	0.19	NRP	acinetobactin	Acinetobacter baumannii
BGC0000936.1	0.18	Other	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0001965.1	0.18	Other	nybomycin	Streptomyces albus subsp. chlorinus
BGC0001444.1	0.16	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.15	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001221.1	0.14	Other (Phenazine)	marinophenazine A, phenaziterpene A	Streptomyces sp. CNQ-509
BGC0000451.1	0.14	NRP	turnerbactin	Teredinibacter turnerae T7901
BGC0001080.1	0.14	Other (Phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0001783.1	0.13	Other	streptonigrin	Streptomyces flocculus
BGC0001850.1	0.13	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000294.1	0.52	NRP	acinetobactin	Acinetobacter baumannii
BGC0000936.1	0.50	Other	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0001965.1	0.49	Other	nybomycin	Streptomyces albus subsp. chlorinus
BGC0001444.1	0.47	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.45	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001221.1	0.43	Other (Phenazine)	marinophenazine A, phenaziterpene A	Streptomyces sp. CNQ-509
BGC0000451.1	0.43	NRP	turnerbactin	Teredinibacter turnerae T7901
BGC0001080.1	0.43	Other (Phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0001783.1	0.42	Other	streptonigrin	Streptomyces flocculus
BGC0001850.1	0.42	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001

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NZ_CP053391.1 - Region 4 - betalactone

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Location: 2,406,754 - 2,435,834 nt. (total: 29,081 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000662.1	0.24	Terpene	grixazone	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000258.1	0.21	Polyketide	prodigiosin	Serratia sp.
BGC0001897.1	0.20	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000259.1	0.20	Polyketide	prodigiosin	Serratia marcescens
BGC0000234.1	0.20	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000890.1	0.20	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0000891.1	0.20	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0001983.1	0.17	Other	triacsins	Kitasatospora aureofaciens
BGC0000373.1	0.16	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001730.1	0.15	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000662.1	0.57	Terpene	grixazone	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000258.1	0.53	Polyketide	prodigiosin	Serratia sp.
BGC0001897.1	0.52	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000259.1	0.52	Polyketide	prodigiosin	Serratia marcescens
BGC0000234.1	0.52	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000890.1	0.52	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0000891.1	0.52	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0001983.1	0.48	Other	triacsins	Kitasatospora aureofaciens
BGC0000373.1	0.47	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001730.1	0.45	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.

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NZ_CP053391.1 - Region 5 - RiPP-like

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Location: 2,598,209 - 2,609,072 nt. (total: 10,864 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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Similar known gene clusters

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NZ_CP053391.1 - Region 6 - arylpolyene

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Location: 3,056,746 - 3,096,253 nt. (total: 39,508 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000779.1	0.22	Saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000780.1	0.19	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0002008.1	0.17	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001897.1	0.17	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001739.1	0.16	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001343.1	0.16	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000836.1	0.16	Other	APE Ec	Escherichia coli CFT073
BGC0001264.1	0.15	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.15	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001120.1	0.15	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000779.1	0.54	Saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000780.1	0.51	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0002008.1	0.48	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001897.1	0.48	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001739.1	0.47	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001343.1	0.47	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000836.1	0.47	Other	APE Ec	Escherichia coli CFT073
BGC0001264.1	0.45	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.45	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001120.1	0.45	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264

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NZ_CP053391.1 - Region 7 - arylpolyene

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Location: 3,374,435 - 3,418,037 nt. (total: 43,603 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.30	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.28	Other	APE Ec	Escherichia coli CFT073
BGC0000231.1	0.24	Polyketide	griseusin	Streptomyces griseus
BGC0001723.1	0.24	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001591.1	0.23	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.23	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000219.1	0.22	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000234.1	0.22	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000228.1	0.22	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001366.1	0.22	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.63	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.61	Other	APE Ec	Escherichia coli CFT073
BGC0000231.1	0.57	Polyketide	griseusin	Streptomyces griseus
BGC0001723.1	0.57	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001591.1	0.56	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.56	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000219.1	0.56	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000234.1	0.55	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000228.1	0.55	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001366.1	0.54	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

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NZ_CP053391.1 - Region 8 - NRPS,hserlactone

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Location: 3,790,217 - 3,834,176 nt. (total: 43,960 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
hserlactone: Autoind_synth

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000343.1	0.61	NRP	enterobactin	Pseudomonas sp. J465
BGC0001983.1	0.50	Other	triacsins	Kitasatospora aureofaciens
BGC0001831.1	0.47	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001343.1	0.46	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001458.1	0.43	Other (Aminocoumarin)	salinipostin G	Salinispora tropica CNB-440
BGC0002034.1	0.41	Other	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000220.1	0.40	Polyketide	enterocin	Streptomyces maritimus
BGC0000274.1	0.40	Polyketide	tetarimycin A, tetarimycin B	uncultured bacterium
BGC0001185.1	0.39	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000246.1	0.38	Polyketide	mithramycin	Streptomyces argillaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000343.1	0.69	NRP	enterobactin	Pseudomonas sp. J465
BGC0001890.1	0.65	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116
BGC0001615.1	0.65	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000426.1	0.61	NRP	sevadicin	Paenibacillus larvae
BGC0001778.1	0.61	Other	showdomycin	Streptomyces showdoensis
BGC0001983.1	0.61	Other	triacsins	Kitasatospora aureofaciens
BGC0001343.1	0.59	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000417.1	0.59	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0002034.1	0.58	Other	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0001185.1	0.58	NRP	bacillibactin	Bacillus velezensis FZB42

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 8, location 3790216 - 3834176:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_3464

Search NORINE for peptide: strict or relaxed

AMP-binding (488..872): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DIvQLGVvWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 80% (moderate)

ctg1_3467

CAL_domain (162..486): pk

minowa: NH2

Prediction, score:

NH2: 114.6
Acetyl-CoA: 55.1
fatty_acid: 20.2
AHBA: 11.9
shikimic_acid: 0.0

ctg1_3475

Search NORINE for peptide: strict or relaxed

AMP-binding (37..443): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ayyaSAHmVK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 50% (weak)