GCF_027570695.1_ASM2757069v1_genomic - 15 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP107719.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	388,547	437,912	glycopeptidolipid	NRP	30%
Region 2	T3PKS	811,790	852,878	alkylresorcinol	Polyketide	100%
Region 3	NRPS,betalactone,T1PKS	928,570	1,026,361	telomycin	NRP	11%
Region 4	RiPP-like	1,125,817	1,135,505
Region 5	RiPP-like	1,173,753	1,184,619
Region 6	redox-cofactor	1,461,691	1,484,392	salinomycin	Polyketide:Modular type I	6%
Region 7	NRPS-like	2,718,904	2,762,965
Region 8	T1PKS	2,920,333	2,966,374	glycopeptidolipid	NRP	13%
Region 9	NRPS	3,059,480	3,128,451	glycopeptidolipid	NRP	52%
Region 10	ectoine	3,679,184	3,689,576	ectoine	Other	100%
Region 11	NRPS,T1PKS	4,056,648	4,123,730	mycobactin	NRP + Polyketide	90%
Region 12	betalactone,NRPS-like	4,253,834	4,309,921	isonitrile lipopeptides	NRP	100%
Region 13	NAPAA	5,711,851	5,745,783
Region 14	PKS-like	5,816,622	5,857,638
Region 15	T1PKS	6,063,754	6,109,180

NZ_CP107719.1 - Region 1 - T1PKS

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Location: 388,547 - 437,912 nt. (total: 49,366 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001164.1	0.32	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001504.1	0.27	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001283.1	0.27	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001163.1	0.26	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001444.1	0.25	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001831.1	0.24	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001538.1	0.23	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001141.1	0.23	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0000836.1	0.22	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.22	Other	aryl polyenes	Xenorhabdus doucetiae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001164.1	0.66	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001504.1	0.61	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001283.1	0.61	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001163.1	0.60	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001444.1	0.59	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001831.1	0.57	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001538.1	0.57	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001141.1	0.56	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0000836.1	0.55	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.55	Other	aryl polyenes	Xenorhabdus doucetiae

Similar known gene clusters

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 388546 - 437912:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal - redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_394

PKS_AT (544..838): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 189.9
inactive: 120.2
Methylmalonyl-CoA: 73.1
Methoxymalonyl-CoA: 64.4
Propionyl-CoA: 54.7
2-Methylbutyryl-CoA: 38.3
Isobutyryl-CoA: 34.7
fatty_acid: 29.8
Acetyl-CoA: 26.0
Benzoyl-CoA: 23.3
Ethylmalonyl-CoA: 21.0
CHC-CoA: 18.3
trans-1,2-CPDA: 14.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (2104..2401): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.9
inactive: 119.2
Methylmalonyl-CoA: 84.6
Methoxymalonyl-CoA: 70.4
Propionyl-CoA: 63.4
2-Methylbutyryl-CoA: 40.7
Isobutyryl-CoA: 37.2
fatty_acid: 34.1
trans-1,2-CPDA: 30.2
Acetyl-CoA: 29.7
Ethylmalonyl-CoA: 29.1
Benzoyl-CoA: 26.1
CHC-CoA: 22.6
3-Methylbutyryl-CoA: 9.8

ctg1_398

CAL_domain (44..492): pk

minowa: NH2

Prediction, score:

NH2: 96.4
Acetyl-CoA: 32.2
fatty_acid: 19.1
AHBA: 7.9
shikimic_acid: 0.0

NZ_CP107719.1 - Region 2 - T3PKS

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Location: 811,790 - 852,878 nt. (total: 41,089 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.1	0.55	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1	0.32	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001831.1	0.21	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000888.1	0.20	Other	bacilysin	Bacillus sp. CS93
BGC0001848.1	0.20	Other	diazaquinomycin H, diazaquinomycin J	Micromonospora sp. B006
BGC0000219.1	0.20	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000563.1	0.19	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001625.1	0.19	Polyketide	isofuranonaphthoquinone	Streptomyces sp. CB01883
BGC0000914.1	0.18	Other	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0001184.1	0.17	Other	bacilysin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.1	0.81	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1	0.65	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001831.1	0.54	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000888.1	0.53	Other	bacilysin	Bacillus sp. CS93
BGC0001848.1	0.53	Other	diazaquinomycin H, diazaquinomycin J	Micromonospora sp. B006
BGC0000219.1	0.52	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000563.1	0.51	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001625.1	0.50	Polyketide	isofuranonaphthoquinone	Streptomyces sp. CB01883
BGC0000914.1	0.49	Other	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0001184.1	0.49	Other	bacilysin	Bacillus velezensis FZB42

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP107719.1 - Region 3 - NRPS,T1PKS,betalactone

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Location: 928,570 - 1,026,361 nt. (total: 97,792 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001128.1	0.92	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.1	0.92	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.92	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.1	0.91	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001844.1	0.91	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000342.1	0.90	NRP	enniatin	Fusarium equiseti
BGC0001758.1	0.90	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.1	0.89	NRP	AM-toxin	Alternaria alternata
BGC0001131.1	0.84	NRP	ambactin	Xenorhabdus miraniensis
BGC0001825.1	0.83	NRP	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.69	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001185.1	0.69	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001844.1	0.68	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001758.1	0.68	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001023.1	0.67	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001131.1	0.67	NRP	ambactin	Xenorhabdus miraniensis
BGC0000401.1	0.67	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132.1	0.67	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.67	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1	0.67	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 928569 - 1026361:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - NMe-val - X - X - NMe-val) + (thr - thr - ala - ala) + (thr - ala - thr - X) + (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 928569 - 1014286:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - NMe-val - X - X - NMe-val) + (thr - thr - ala - ala) + (thr - ala - thr - X) + (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 981848 - 1026361:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (thr - ala - thr - X) + (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_906

Search NORINE for peptide: strict or relaxed

AMP-binding (464..852): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFwSmAgVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

AMP-binding (1527..1925): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAfLvGAIwK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 70% (weak)

AMP-binding (2999..3386): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFwSmAgVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

AMP-binding (4052..4439): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFwSmAgVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

AMP-binding (5103..5492): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAfLvGAIwK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 70% (weak)

ctg1_907

Search NORINE for peptide: strict or relaxed

AMP-binding (46..447): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DYWSVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1112..1514): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DYWSVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (2180..2570): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DvwSvAAVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

AMP-binding (3238..3622): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DVWNVAgytK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 70% (weak)

ctg1_911

Search NORINE for peptide: strict or relaxed

AMP-binding (45..447): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DYWSVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1111..1497): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DvwSvAAVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

AMP-binding (2162..2564): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DYWSVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (3228..3621): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DywSmAgVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 60% (weak)

ctg1_916

PKS_AT (555..849): mmal

ATSignature: Methylmalonyl-CoA, Malonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 70.8%; Malonyl-CoA: 70.8%; Isobutyryl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 129.2
Methoxymalonyl-CoA: 115.8
Ethylmalonyl-CoA: 111.5
Malonyl-CoA: 90.6
2-Methylbutyryl-CoA: 88.2
Propionyl-CoA: 81.5
trans-1,2-CPDA: 70.2
Isobutyryl-CoA: 65.3
CHC-CoA: 60.8
Acetyl-CoA: 60.5
fatty_acid: 46.5
Benzoyl-CoA: 41.6
inactive: 30.5
3-Methylbutyryl-CoA: 29.8

ctg1_917

CAL_domain (39..480): pk

minowa: NH2

Prediction, score:

NH2: 76.0
Acetyl-CoA: 27.2
fatty_acid: 18.8
AHBA: 10.2
shikimic_acid: 0.0

NZ_CP107719.1 - Region 4 - RiPP-like

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Location: 1,125,817 - 1,135,505 nt. (total: 9,689 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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MIBiG comparison

KnownClusterBlast

Pfam domains

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Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0001882.1		0.19	Polyketide	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0001985.1		0.13	Other	pyrazomycin	Streptomyces candidus

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0001882.1		0.51	Polyketide	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0001985.1		0.41	Other	pyrazomycin	Streptomyces candidus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_CP107719.1 - Region 5 - RiPP-like

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Location: 1,173,753 - 1,184,619 nt. (total: 10,867 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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KnownClusterBlast

Pfam domains

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Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0000514.1		0.04	RiPP	gallidermin	Staphylococcus gallinarum

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000514.1		0.18	RiPP	gallidermin	Staphylococcus gallinarum

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_CP107719.1 - Region 6 - redox-cofactor

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Location: 1,461,691 - 1,484,392 nt. (total: 22,702 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.1	0.27	Other	3-demethylchuangxinmycin	Actinoplanes tsinanensis
BGC0001546.1	0.27	Alkaloid	chuangxinmycin	Actinoplanes tsinanensis
BGC0001336.1	0.21	Alkaloid	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000886.1	0.21	Other	allylmalonyl-CoA	Streptomyces tsukubensis
BGC0000663.1	0.21	Terpene	hopene	Streptomyces coelicolor A3(2)
BGC0001483.1	0.21	Other	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0000874.1	0.20	Other	blasticidin S	Streptomyces griseochromogenes
BGC0001782.1	0.20	Other	spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G	Streptomyces sp. SCSIO 03032
BGC0000823.1	0.20	Alkaloid	rebeccamycin	Lechevalieria aerocolonigenes
BGC0001223.1	0.20	Other	hydroxysporine	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.1	0.61	Other	3-demethylchuangxinmycin	Actinoplanes tsinanensis
BGC0001546.1	0.61	Alkaloid	chuangxinmycin	Actinoplanes tsinanensis
BGC0001336.1	0.54	Alkaloid	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000886.1	0.54	Other	allylmalonyl-CoA	Streptomyces tsukubensis
BGC0000663.1	0.54	Terpene	hopene	Streptomyces coelicolor A3(2)
BGC0001483.1	0.53	Other	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0000874.1	0.53	Other	blasticidin S	Streptomyces griseochromogenes
BGC0001782.1	0.53	Other	spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G	Streptomyces sp. SCSIO 03032
BGC0000823.1	0.53	Alkaloid	rebeccamycin	Lechevalieria aerocolonigenes
BGC0001223.1	0.52	Other	hydroxysporine	uncultured bacterium

Similar known gene clusters

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Detailed TIGRFAM domain annotation

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NZ_CP107719.1 - Region 7 - NRPS-like

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Location: 2,718,904 - 2,762,965 nt. (total: 44,062 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

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Pfam domains

TIGRFAM domains

Detailed domain annotation

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000858.1	0.47	Other	ectoine	Methylobacter marinus
BGC0000853.1	0.47	Other	ectoine	Streptomyces anulatus
BGC0000856.1	0.47	Other	ectoine	Methylophaga thalassica
BGC0001151.1	0.42	Other (Non-NRP beta-lactam)	valclavam, (-)-2-(2-hydroxyethyl)clavam	Streptomyces antibioticus
BGC0001627.1	0.42	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0000805.1	0.41	Saccharide	moenomycin	Streptomyces viridosporus ATCC 14672
BGC0001900.1	0.41	NRP	fragin	Burkholderia cenocepacia H111
BGC0001591.1	0.40	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.40	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000313.1	0.38	NRP	beauvericin	Beauveria bassiana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000858.1	0.57	Other	ectoine	Methylobacter marinus
BGC0000853.1	0.57	Other	ectoine	Streptomyces anulatus
BGC0000856.1	0.57	Other	ectoine	Methylophaga thalassica
BGC0001151.1	0.55	Other (Non-NRP beta-lactam)	valclavam, (-)-2-(2-hydroxyethyl)clavam	Streptomyces antibioticus
BGC0001627.1	0.54	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001591.1	0.54	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.54	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000805.1	0.53	Saccharide	moenomycin	Streptomyces viridosporus ATCC 14672
BGC0001900.1	0.53	NRP	fragin	Burkholderia cenocepacia H111
BGC0000313.1	0.51	NRP	beauvericin	Beauveria bassiana

Similar known gene clusters

No matches found.

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 9, location 2718903 - 2762965:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 10, location 2718903 - 2759721:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 11, location 2721092 - 2762965:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2668

Search NORINE for peptide: strict or relaxed

AMP-binding (83..506): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: vmGsVAGsvK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 50% (weak)

ctg1_2669

Search NORINE for peptide: strict or relaxed

AMP-binding (83..513): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: vmGnVGGmaK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 50% (weak)

NZ_CP107719.1 - Region 8 - T1PKS

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Location: 2,920,333 - 2,966,374 nt. (total: 46,042 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

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Pfam domains

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Detailed domain annotation

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001340.1	0.30	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0001749.1	0.30	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001538.1	0.29	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001124.1	0.29	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0000046.1	0.28	Polyketide	depudecin	Alternaria brassicicola
BGC0001913.1	0.28	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001067.1	0.28	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0001444.1	0.27	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001504.1	0.26	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001697.1	0.26	Polyketide	neurosporin A	Neurospora crassa OR74A

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001340.1	0.64	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0001749.1	0.63	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001538.1	0.63	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001124.1	0.63	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0000046.1	0.62	Polyketide	depudecin	Alternaria brassicicola
BGC0001913.1	0.61	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001067.1	0.61	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0001444.1	0.60	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001504.1	0.60	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001697.1	0.60	Polyketide	neurosporin A	Neurospora crassa OR74A

Similar known gene clusters

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 12, location 2920332 - 2966374:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2852

PKS_AT (533..827): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Ethylmalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 135.9
Ethylmalonyl-CoA: 116.2
Methoxymalonyl-CoA: 112.9
Malonyl-CoA: 97.2
2-Methylbutyryl-CoA: 90.4
Propionyl-CoA: 79.5
Isobutyryl-CoA: 68.7
Acetyl-CoA: 62.4
fatty_acid: 61.5
trans-1,2-CPDA: 61.2
CHC-CoA: 55.0
Benzoyl-CoA: 39.1
inactive: 33.1
3-Methylbutyryl-CoA: 29.8

ctg1_2854

CAL_domain (163..477): pk

minowa: NH2

Prediction, score:

NH2: 84.4
Acetyl-CoA: 38.8
fatty_acid: 14.6
AHBA: 8.8
shikimic_acid: 0.0

NZ_CP107719.1 - Region 9 - NRPS

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Location: 3,059,480 - 3,128,451 nt. (total: 68,972 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

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Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.38	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.37	NRP	sevadicin	Paenibacillus larvae
BGC0001479.1	0.34	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001790.1	0.33	NRP	sulfazecin	Pseudomonas acidophila
BGC0000410.1	0.32	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001128.1	0.32	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1	0.32	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.31	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.31	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000348.1	0.31	NRP	ergovaline	Epichloe festucae var. lolii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.70	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.69	NRP	sevadicin	Paenibacillus larvae
BGC0001479.1	0.67	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001790.1	0.66	NRP	sulfazecin	Pseudomonas acidophila
BGC0000410.1	0.65	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001128.1	0.65	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1	0.65	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.65	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.65	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000348.1	0.64	NRP	ergovaline	Epichloe festucae var. lolii

Similar known gene clusters

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 13, location 3059479 - 3128451:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-thr - ala - D-phe - ala - tyr - D-thr) + (thr - D-thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2969

Search NORINE for peptide: strict or relaxed

AMP-binding (429..831): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWSVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1957..2347): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DvwSvAAVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

AMP-binding (3009..3401): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DvWTvVAmCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

AMP-binding (4507..4898): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DFwtvGVmWK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 60% (weak)

AMP-binding (5565..5959): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DAesLaAICK
Nearest Stachelhaus code:: bht
Stachelhaus code match:: 70% (weak)

AMP-binding (6628..7021): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFwtLgAVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

ctg1_2970

Search NORINE for peptide: strict or relaxed

AMP-binding (45..447): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWSVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1114..1519): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWSVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

NZ_CP107719.1 - Region 10 - ectoine

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Location: 3,679,184 - 3,689,576 nt. (total: 10,393 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.1	0.53	Other	ectoine	Streptomyces anulatus
BGC0000852.1	0.50	Other	ectoine	Sporosarcina pasteurii
BGC0000855.1	0.40	Other	ectoine	Methylomicrobium kenyense
BGC0000856.1	0.40	Other	ectoine	Methylophaga thalassica
BGC0000859.1	0.33	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000858.1	0.32	Other	ectoine	Methylobacter marinus
BGC0000860.1	0.30	Other	ectoine	Methylarcula marina
BGC0000857.1	0.30	Other	ectoine	Methylophaga alcalica
BGC0000854.1	0.28	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000895.1	0.14	Other	citrulline	Lactobacillus plantarum subsp. plantarum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.1	0.80	Other	ectoine	Streptomyces anulatus
BGC0000852.1	0.79	Other	ectoine	Sporosarcina pasteurii
BGC0000855.1	0.72	Other	ectoine	Methylomicrobium kenyense
BGC0000856.1	0.72	Other	ectoine	Methylophaga thalassica
BGC0000859.1	0.66	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000858.1	0.66	Other	ectoine	Methylobacter marinus
BGC0000860.1	0.64	Other	ectoine	Methylarcula marina
BGC0000857.1	0.64	Other	ectoine	Methylophaga alcalica
BGC0000854.1	0.62	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000895.1	0.43	Other	citrulline	Lactobacillus plantarum subsp. plantarum

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP107719.1 - Region 11 - NRPS,T1PKS

Download region GenBank file

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Location: 4,056,648 - 4,123,730 nt. (total: 67,083 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

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Pfam domains

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Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.1	0.72	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001021.1	0.65	NRP, Polyketide	mycobactin	Mycobacterium tuberculosis H37Rv
BGC0001027.1	0.64	NRP, Polyketide	nocobactin NA	Nocardia farcinica IFM 10152
BGC0000457.1	0.62	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001050.1	0.60	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000465.1	0.59	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001023.1	0.57	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000389.1	0.56	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000160.1	0.55	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000426.1	0.53	NRP	sevadicin	Paenibacillus larvae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001021.1	0.71	NRP, Polyketide	mycobactin	Mycobacterium tuberculosis H37Rv
BGC0001276.1	0.69	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001027.1	0.68	NRP, Polyketide	nocobactin NA	Nocardia farcinica IFM 10152
BGC0000465.1	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000426.1	0.66	NRP	sevadicin	Paenibacillus larvae
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001023.1	0.64	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001050.1	0.64	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000160.1	0.63	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000352.1	0.63	NRP	fimsbactin A	Acinetobacter sp. ADP1

Similar known gene clusters

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 15, location 4056647 - 4123730:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (X) + (Me-ohmal) + (lys) + (D-lys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 16, location 4056647 - 4115979:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (X) + (Me-ohmal) + (lys) + (D-lys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 17, location 4081071 - 4123730:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (X) + (Me-ohmal) + (lys) + (D-lys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_3919

Search NORINE for peptide: strict or relaxed

AMP-binding (467..856): lys

NRPSPredictor2: lys

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: lys

Stachelhaus prediction details:

Stachelhaus sequence:: DAwDAGCVEK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 90% (moderate)

ctg1_3920

Search NORINE for peptide: strict or relaxed

AMP-binding (494..877): lys

NRPSPredictor2: lys

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: lys

Stachelhaus prediction details:

Stachelhaus sequence:: DVgHPGFlNK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 80% (moderate)

ctg1_3921

PKS_AT (105..401): mmal

ATSignature: 2-Methylbutyryl-CoA

Top 3 matches:: 2-Methylbutyryl-CoA: 62.5%; Malonyl-CoA: 58.3%; Isobutyryl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 99.5
Methoxymalonyl-CoA: 85.6
Ethylmalonyl-CoA: 84.7
Malonyl-CoA: 64.7
2-Methylbutyryl-CoA: 48.8
trans-1,2-CPDA: 45.7
Propionyl-CoA: 43.7
CHC-CoA: 39.1
Isobutyryl-CoA: 38.2
Benzoyl-CoA: 33.5
inactive: 26.6
fatty_acid: 16.6
Acetyl-CoA: 13.8
3-Methylbutyryl-CoA: 13.2

ctg1_3925

Search NORINE for peptide: strict or relaxed

AMP-binding (550..951): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: cys
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DliHpGLthK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 50% (weak)

ctg1_3926

Search NORINE for peptide: strict or relaxed

AMP-binding (42..452): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PfPgQGiLNK
Nearest Stachelhaus code:: sal
Stachelhaus code match:: 70% (weak)

ctg1_3928

PKS_AT (538..832): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; Methylmalonyl-CoA: 70.8%; Propionyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 106.9
Methoxymalonyl-CoA: 84.9
Ethylmalonyl-CoA: 76.9
Malonyl-CoA: 69.2
Isobutyryl-CoA: 59.2
Acetyl-CoA: 47.0
trans-1,2-CPDA: 39.5
Propionyl-CoA: 37.4
Benzoyl-CoA: 32.6
3-Methylbutyryl-CoA: 28.1
2-Methylbutyryl-CoA: 27.1
fatty_acid: 23.7
inactive: 17.3
CHC-CoA: 10.3

NZ_CP107719.1 - Region 12 - NRPS-like,betalactone

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Location: 4,253,834 - 4,309,921 nt. (total: 56,088 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Detailed domain annotation

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000234.1	0.46	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001627.1	0.35	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0000253.1	0.31	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000261.1	0.30	Polyketide	R1128	Streptomyces sp. R1128
BGC0001730.1	0.28	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.
BGC0001996.1	0.26	Other	oryzine A, oryzine B	Aspergillus oryzae RIB40
BGC0000937.1	0.26	Other	fosfazinomycin A	Streptomyces sp. WM6372
BGC0000350.1	0.26	NRP	ET-743	uncultured organism
BGC0000897.1	0.25	Other	dehydrophos	Streptomyces luridus
BGC0001831.1	0.25	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001627.1	0.70	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0000234.1	0.58	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001831.1	0.58	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000253.1	0.57	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000261.1	0.56	Polyketide	R1128	Streptomyces sp. R1128
BGC0001730.1	0.53	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.
BGC0000244.1	0.53	Polyketide	macrotetrolide	Streptomyces griseus subsp. griseus
BGC0001897.1	0.51	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000723.1	0.51	Saccharide	β-D-galactosylvalidoxylamine-A	Streptomyces hygroscopicus subsp. limoneus
BGC0000259.1	0.51	Polyketide	prodigiosin	Serratia marcescens

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP107719.1 - Region 13 - NAPAA

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Location: 5,711,851 - 5,745,783 nt. (total: 33,933 nt) Show pHMM detection rules used

NAPAA: (AMP-binding and PP-binding and TIGR02353)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001900.1	0.22	NRP	fragin	Burkholderia cenocepacia H111
BGC0001168.1	0.21	NRP	livipeptin	Streptomyces lividans 1326
BGC0000427.1	0.21	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001758.1	0.18	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000308.1	0.18	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001399.1	0.18	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001517.1	0.18	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0000334.1	0.18	NRP	cyclosporine	Tolypocladium inflatum NRRL8044
BGC0001844.1	0.18	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.18	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001900.1	0.54	NRP	fragin	Burkholderia cenocepacia H111
BGC0001168.1	0.54	NRP	livipeptin	Streptomyces lividans 1326
BGC0000427.1	0.53	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001758.1	0.50	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000308.1	0.50	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001399.1	0.50	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001517.1	0.50	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0000334.1	0.50	NRP	cyclosporine	Tolypocladium inflatum NRRL8044
BGC0001844.1	0.50	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.50	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters

No matches found.

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 21, location 5711850 - 5745783:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_5513

Search NORINE for peptide: strict or relaxed

AMP-binding (31..403): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: gly, ala
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAESIGtVvK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 80% (moderate)

NZ_CP107719.1 - Region 14 - PKS-like

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Location: 5,816,622 - 5,857,638 nt. (total: 41,017 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001150.1	0.15	Polyketide	pamamycin-607	Streptomyces alboniger
BGC0001783.1	0.14	Other	streptonigrin	Streptomyces flocculus
BGC0001538.1	0.10	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001283.1	0.08	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001302.1	0.08	Other	lomofungin	Streptomyces lomondensis
BGC0001920.1	0.08	RiPP	siamycin I	Streptomyces sp.
BGC0000275.1	0.07	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001440.1	0.07	Other	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0000652.1	0.07	Terpene	napyradiomycin	Streptomyces sp. CNQ525
BGC0001755.1	0.07	Polyketide	reedsmycins	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001150.1	0.45	Polyketide	pamamycin-607	Streptomyces alboniger
BGC0001783.1	0.43	Other	streptonigrin	Streptomyces flocculus
BGC0001538.1	0.35	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001283.1	0.31	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001302.1	0.30	Other	lomofungin	Streptomyces lomondensis
BGC0001920.1	0.30	RiPP	siamycin I	Streptomyces sp.
BGC0000275.1	0.29	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001440.1	0.29	Other	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0000652.1	0.28	Terpene	napyradiomycin	Streptomyces sp. CNQ525
BGC0001755.1	0.28	Polyketide	reedsmycins	Streptomyces sp.

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_CP107719.1 - Region 15 - T1PKS

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Location: 6,063,754 - 6,109,180 nt. (total: 45,427 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001831.1	0.24	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001704.1	0.22	Other	nocuolin A	Nodularia sp. HBU26
BGC0000632.1	0.22	Terpene, Saccharide	brasilicardin A	Nocardia terpenica
BGC0001161.1	0.21	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.21	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.21	Polyketide	1-heptadecene	Moorea producens JHB
BGC0000044.1	0.20	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0000138.1	0.20	Polyketide	rimocidin	Streptomyces diastaticus
BGC0001458.1	0.20	Other (Aminocoumarin)	salinipostin G	Salinispora tropica CNB-440
BGC0002019.1	0.20	Terpene	tiancilactone	Streptomyces sp. CB03234

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001831.1	0.58	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001704.1	0.55	Other	nocuolin A	Nodularia sp. HBU26
BGC0000632.1	0.55	Terpene, Saccharide	brasilicardin A	Nocardia terpenica
BGC0001161.1	0.54	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.54	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.54	Polyketide	1-heptadecene	Moorea producens JHB
BGC0000044.1	0.53	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0000138.1	0.53	Polyketide	rimocidin	Streptomyces diastaticus
BGC0001458.1	0.52	Other (Aminocoumarin)	salinipostin G	Salinispora tropica CNB-440
BGC0002019.1	0.52	Terpene	tiancilactone	Streptomyces sp. CB03234

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 23, location 6063753 - 6109180:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_5835

Search NORINE for peptide: strict or relaxed

AMP-binding (8..386): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ngvsvGGCAK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 50% (weak)

ctg1_5838

PKS_AT (730..1040): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 62.5%; Methoxymalonyl-CoA: 58.3%; Malonyl-CoA: 54.2%

minowa: fatty_acid

Prediction, score:

fatty_acid: 143.5
Methylmalonyl-CoA: 77.6
Methoxymalonyl-CoA: 68.2
Ethylmalonyl-CoA: 56.2
Malonyl-CoA: 49.0
Propionyl-CoA: 43.8
trans-1,2-CPDA: 35.4
CHC-CoA: 27.6
Isobutyryl-CoA: 27.5
2-Methylbutyryl-CoA: 23.4
inactive: 12.1
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg1_5839

CAL_domain (180..514): pk

minowa: NH2

Prediction, score:

NH2: 69.3
Acetyl-CoA: 30.1
fatty_acid: 13.2
shikimic_acid: 0.0
AHBA: 0.0