LOCUS       NZ_CP018019.1          10798 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP018019.1 Mycobacterium avium subsp. hominissuis strain
            OCU889s_P11_4s chromosome, complete genome.
ACCESSION   NZ_CP018019
VERSION     NZ_CP018019.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:01:50
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 642380
            Orig. end    :: 653178
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10798
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[647380:648178](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5798)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10798
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10798
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(705..1286)
                     /locus_tag="ctg1_629"
                     /transl_table=11
                     /translation="VLFDPGTFAHGFEGITGLTAILITHQHPDHIDATRLPALLEGNPD
                     AALYADPQTTAQLGAPCRAVHVGDELQIGELTVRAVGGKHAVIHPEIPVIENISFLVGD
                     GGHRARLMHPGDALFVPDEPVDVLATPAAAPWMKVSEAVDYLRAVAPARAVPIHQGIIA
                     PDARGIYYGRLSEMTSTDFQVLPEEDAVTF"
     PFAM_domain     complement(813..1286)
                     /aSDomain="Lactamase_B_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13483.8"
                     /description="Beta-lactamase superfamily domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_629_0045"
                     /evalue="5.60E-15"
                     /label="ctg1_629"
                     /locus_tag="ctg1_629"
                     /protein_end="158"
                     /protein_start="0"
                     /score="55.7"
                     /tool="antismash"
                     /translation="VLFDPGTFAHGFEGITGLTAILITHQHPDHIDATRLPALLEGNPD
                     AALYADPQTTAQLGAPCRAVHVGDELQIGELTVRAVGGKHAVIHPEIPVIENISFLVGD
                     GGHRARLMHPGDALFVPDEPVDVLATPAAAPWMKVSEAVDYLRAVAPARAVPIH"
     CDS             1320..2054
                     /locus_tag="ctg1_630"
                     /transl_table=11
                     /translation="MAEMRQLHIYDCALMDKLPMRVFLATMVVAGSFAVALIVVMPAYG
                     EPETCPGICDRIPNTAWIDQHAVPLDAVYHWPALAGQAAHTTGAAPGPRFRFEELCGAP
                     ALPQDPRDSAVVARSTVAHPDGQWQLQAQVLHWRGDTAHGGAVAATVFGNAVAALRGCQ
                     QRAPQESPSLTSDEPTRMAAVISGPVVMHTYLLAHPASSTISELTLWSSAPPQTPWPAM
                     ADDPVLGAMNASLCEAYIASCP"
     CDS             2117..2356
                     /locus_tag="ctg1_631"
                     /transl_table=11
                     /translation="VARVIVSVMPKAEILDPQGQAIVGALGRLGHSGISDVRQGKRFEL
                     EVDDSVDDAALAEIAETLLANTVIEDWTISRETQ"
     PFAM_domain     2126..2338
                     /aSDomain="PurS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02700.16"
                     /description="Phosphoribosylformylglycinamidine (FGAM)
                     synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_631_0046"
                     /evalue="2.30E-24"
                     /label="ctg1_631"
                     /locus_tag="ctg1_631"
                     /protein_end="74"
                     /protein_start="3"
                     /score="85.4"
                     /tool="antismash"
                     /translation="VIVSVMPKAEILDPQGQAIVGALGRLGHSGISDVRQGKRFELEVD
                     DSVDDAALAEIAETLLANTVIEDWTI"
     aSDomain        2129..2341
                     /aSDomain="TIGR00302"
                     /aSTool="tigrfam"
                     /description="TIGR00302: phosphoribosylformylglycinamidine
                     synthase, purS protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_631_0006"
                     /evalue="7.60E-15"
                     /identifier="TIGR00302"
                     /label="ctg1_631"
                     /locus_tag="ctg1_631"
                     /protein_end="75"
                     /protein_start="4"
                     /score="52.9"
                     /tool="antismash"
                     /translation="IVSVMPKAEILDPQGQAIVGALGRLGHSGISDVRQGKRFELEVDD
                     SVDDAALAEIAETLLANTVIEDWTIS"
     CDS             2353..3027
                     /locus_tag="ctg1_632"
                     /transl_table=11
                     /translation="VTARIGIITFPGTLDDVDAARAARRVGAQPVSLWHADADLKGVDA
                     VVVPGGFSYGDYLRAGAIARFAPVMAEVVDAARRGMPVLGICNGFQVLCEAGLLPGALT
                     RNVGLHFICRDVWLRVASTSTAWTSRFEPDADLLVPLKSGEGRYVAPADVLDELEGEGR
                     VVFRYHENLNGSQRDIAGVSSADGRVVGLMPHPEHAIEALTGPSDDGLGLFYSVLDGVL
                     AG"
     PFAM_domain     2362..2967
                     /aSDomain="GATase_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13507.8"
                     /description="CobB/CobQ-like glutamine amidotransferase
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_632_0047"
                     /evalue="2.10E-34"
                     /label="ctg1_632"
                     /locus_tag="ctg1_632"
                     /protein_end="205"
                     /protein_start="3"
                     /score="118.9"
                     /tool="antismash"
                     /translation="RIGIITFPGTLDDVDAARAARRVGAQPVSLWHADADLKGVDAVVV
                     PGGFSYGDYLRAGAIARFAPVMAEVVDAARRGMPVLGICNGFQVLCEAGLLPGALTRNV
                     GLHFICRDVWLRVASTSTAWTSRFEPDADLLVPLKSGEGRYVAPADVLDELEGEGRVVF
                     RYHENLNGSQRDIAGVSSADGRVVGLMPHPEHAIEALTG"
     aSDomain        2362..3009
                     /aSDomain="TIGR01737"
                     /aSTool="tigrfam"
                     /description="FGAM_synth_I:
                     phosphoribosylformylglycinamidine synthase I"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_632_0007"
                     /evalue="1.80E-78"
                     /identifier="TIGR01737"
                     /label="ctg1_632"
                     /locus_tag="ctg1_632"
                     /protein_end="219"
                     /protein_start="3"
                     /score="260.9"
                     /tool="antismash"
                     /translation="RIGIITFPGTLDDVDAARAARRVGAQPVSLWHADADLKGVDAVVV
                     PGGFSYGDYLRAGAIARFAPVMAEVVDAARRGMPVLGICNGFQVLCEAGLLPGALTRNV
                     GLHFICRDVWLRVASTSTAWTSRFEPDADLLVPLKSGEGRYVAPADVLDELEGEGRVVF
                     RYHENLNGSQRDIAGVSSADGRVVGLMPHPEHAIEALTGPSDDGLGLFYSVLD"
     CDS             complement(3039..3557)
                     /locus_tag="ctg1_633"
                     /transl_table=11
                     /translation="VAHRLAPSVRKFAGGSMFVMTNEQSCANLVERYLRTRGRRYFRGH
                     HDGEYFFVTAAPRRLHVRFEISPAHDDVLIIRVSPGYYFPASDRPWLTHFSDRWNRLGR
                     RVTAIVHGSSDPQRIGVTARKSQWIRNGVGFTDFAAFLDETIADATELFEELNPAAPPA
                     HAPLLRDAG"
     CDS             complement(3585..4406)
                     /gene_functions="regulatory (smcogs) SMCOG1136:GntR family
                     transcriptional regulator (Score: 184; E-value: 5.4e-56)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_634"
                     /transl_table=11
                     /translation="VVPDQLDLDAADLRISRGSVPASTQLAEALKAAIVKQRLPRGARL
                     PTERELVDRTRVSRVTVRAAVGLLERQGWLVRRQGLGTFVANPVKQELGPGVRTITEVL
                     AASGITPNVDVLSHRVEDAPQRIAETLHLTKVLCVHRRFRDGEQPLALMIAYLPPGLGK
                     AVEPLLKSATDTQTGRAMESTYTMWERRLDTPIARASYEIHAAGASVEVAGALNLPLGS
                     PVLVLERTSYGHDDTPLEVVEFHYRPERYRFSVTLPRTVPGPGAGIVERSG"
     PFAM_domain     complement(3651..4088)
                     /aSDomain="UTRA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07702.15"
                     /description="UTRA domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_634_0049"
                     /evalue="1.70E-28"
                     /label="ctg1_634"
                     /locus_tag="ctg1_634"
                     /protein_end="252"
                     /protein_start="106"
                     /score="99.4"
                     /tool="antismash"
                     /translation="SGITPNVDVLSHRVEDAPQRIAETLHLTKVLCVHRRFRDGEQPLA
                     LMIAYLPPGLGKAVEPLLKSATDTQTGRAMESTYTMWERRLDTPIARASYEIHAAGASV
                     EVAGALNLPLGSPVLVLERTSYGHDDTPLEVVEFHYRPERYR"
     PFAM_domain     complement(4152..4337)
                     /aSDomain="GntR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00392.23"
                     /description="Bacterial regulatory proteins, gntR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_634_0048"
                     /evalue="2.00E-16"
                     /label="ctg1_634"
                     /locus_tag="ctg1_634"
                     /protein_end="85"
                     /protein_start="23"
                     /score="59.5"
                     /tool="antismash"
                     /translation="TQLAEALKAAIVKQRLPRGARLPTERELVDRTRVSRVTVRAAVGL
                     LERQGWLVRRQGLGTFV"
     CDS             complement(4527..4994)
                     /locus_tag="ctg1_635"
                     /transl_table=11
                     /translation="MATADGFHPDFDDATPHVARNRVYHVKASQLSSDTAQSEGLRRFA
                     ALSGNSVGSEKLWMGETHAFPGSASDNHHHGESETAIYVRTGNPEFVFHDGVHEVRIAT
                     APGDYVFIPPYLPHREENPDPHTTAEVVIARSTQEAIVVNLPALYPLTDPD"
     PFAM_domain     complement(4617..4799)
                     /aSDomain="Cupin_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07883.13"
                     /description="Cupin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_635_0050"
                     /evalue="9.50E-07"
                     /label="ctg1_635"
                     /locus_tag="ctg1_635"
                     /protein_end="126"
                     /protein_start="65"
                     /score="28.5"
                     /tool="antismash"
                     /translation="PGSASDNHHHGESETAIYVRTGNPEFVFHDGVHEVRIATAPGDYV
                     FIPPYLPHREENPDPH"
     CDS             complement(5001..5798)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_636"
                     /sec_met_domain="Linocin_M18 (E-value: 6.2e-94, bitscore:
                     312.0, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLYRDLAPVTEAAWGEIELEASRTFKRHVAGRRVVDVSEPGGP
                     AAAAVSTGRLIDVEAPTNGVVAHLRASKPLVRLRVPFTLSRYEIDNVERGANDSDWDPV
                     KEAAKKLAFVEDRAIFEGYAAASIDGIRSASSNKPLALPADPREIPDVITQAISELRLA
                     GVDGPYSVLLSADVYTKVSETTEHGYPILEHIDRLVPGDIIWAPAIDGAFVLTTRGGDF
                     DLQLGTDVSIGYTSHDADTVQLYLQETLTFLCYTAEAAVPLTS"
     PFAM_domain     complement(5046..5798)
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_636_0051"
                     /evalue="1.20E-94"
                     /label="ctg1_636"
                     /locus_tag="ctg1_636"
                     /protein_end="251"
                     /protein_start="0"
                     /score="316.5"
                     /tool="antismash"
                     /translation="MNNLYRDLAPVTEAAWGEIELEASRTFKRHVAGRRVVDVSEPGGP
                     AAAAVSTGRLIDVEAPTNGVVAHLRASKPLVRLRVPFTLSRYEIDNVERGANDSDWDPV
                     KEAAKKLAFVEDRAIFEGYAAASIDGIRSASSNKPLALPADPREIPDVITQAISELRLA
                     GVDGPYSVLLSADVYTKVSETTEHGYPILEHIDRLVPGDIIWAPAIDGAFVLTTRGGDF
                     DLQLGTDVSIGYTSHDADTVQLYLQETLT"
     CDS             complement(5795..6805)
                     /locus_tag="ctg1_637"
                     /transl_table=11
                     /translation="VPPVQPQPILAPLTPAAIFLVLTVDDGGEATVHEALQDISGLVRA
                     IGFREPQKRLSAIASIGSDVWDRLFSGPRPAELHRFVELHGPRHTAPATPGDLLFHIRA
                     ESLDVCFELADRILKSMAGAVTVVDEVHGFRYFDNRDLLGFVDGTENPDGALAVSSTAI
                     GDEDPDFAGSCYVHVQKYLHDMSAWTALSVTEQENVIGRTKLDDIELDDDVKPADAHIA
                     LNVITDDDGTELKIVRHNMPFGELGKSEYGTYFIGYSRTPRVTEQMLRNMFLGDPPGNT
                     DRILDFSTAVTGGLFFSPTVDFLDDPPPLPAPGTPAAPPARNGSLSIGSLKGTTR"
     aSDomain        complement(5897..6787)
                     /aSDomain="TIGR01413"
                     /aSTool="tigrfam"
                     /description="Dyp_perox_fam: Dyp-type peroxidase family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_637_0008"
                     /evalue="7.10E-87"
                     /identifier="TIGR01413"
                     /label="ctg1_637"
                     /locus_tag="ctg1_637"
                     /protein_end="303"
                     /protein_start="6"
                     /score="289.7"
                     /tool="antismash"
                     /translation="QPILAPLTPAAIFLVLTVDDGGEATVHEALQDISGLVRAIGFREP
                     QKRLSAIASIGSDVWDRLFSGPRPAELHRFVELHGPRHTAPATPGDLLFHIRAESLDVC
                     FELADRILKSMAGAVTVVDEVHGFRYFDNRDLLGFVDGTENPDGALAVSSTAIGDEDPD
                     FAGSCYVHVQKYLHDMSAWTALSVTEQENVIGRTKLDDIELDDDVKPADAHIALNVITD
                     DDGTELKIVRHNMPFGELGKSEYGTYFIGYSRTPRVTEQMLRNMFLGDPPGNTDRILDF
                     STAVTGGLFFSPTVDF"
     PFAM_domain     complement(5897..6787)
                     /aSDomain="Dyp_perox"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04261.14"
                     /description="Dyp-type peroxidase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_637_0052"
                     /evalue="1.70E-95"
                     /label="ctg1_637"
                     /locus_tag="ctg1_637"
                     /protein_end="303"
                     /protein_start="6"
                     /score="319.9"
                     /tool="antismash"
                     /translation="QPILAPLTPAAIFLVLTVDDGGEATVHEALQDISGLVRAIGFREP
                     QKRLSAIASIGSDVWDRLFSGPRPAELHRFVELHGPRHTAPATPGDLLFHIRAESLDVC
                     FELADRILKSMAGAVTVVDEVHGFRYFDNRDLLGFVDGTENPDGALAVSSTAIGDEDPD
                     FAGSCYVHVQKYLHDMSAWTALSVTEQENVIGRTKLDDIELDDDVKPADAHIALNVITD
                     DDGTELKIVRHNMPFGELGKSEYGTYFIGYSRTPRVTEQMLRNMFLGDPPGNTDRILDF
                     STAVTGGLFFSPTVDF"
     CDS             6846..8156
                     /locus_tag="ctg1_638"
                     /transl_table=11
                     /translation="MMFTMSGGPRNQTKSSASAQGLCEFIDASPSPFHVCATVAARLIA
                     AGYTELDEAKHWPSQPGRYFTVRAGSLVAWDSTGADGPFRIVGAHTDSPNLRVKQHPDR
                     TVAGWRVVALQPYGGAWLNSWLDRDLGISGRLSVRDGSGLSHRLVRIDEPILRVPQLAI
                     HLAEDRKSVTLDPQRHLNAVWGVGESARSFVDYVAARAAVAPGDVLAADLMTHDLTPST
                     LIGASENGTADLLSAPRLDNQASCYAGLEALLATEPSGPLPVLVLFDHEEVGSSSDHGA
                     HSDLLSTVLERIVLAAGGTRQDYLSRLPASLLASADMAHATHPNYPERHEPGHPIAVNA
                     GPVLKVHPNLRYATDSRTAAAFALDCRQAGVTLQRYEHRADLPCGSTIGPLAAARTGIP
                     TVDVGAAQLAMHSARELMGAHDVAAYSAAMHAFLSPG"
     PFAM_domain     6918..8141
                     /aSDomain="Peptidase_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02127.17"
                     /description="Aminopeptidase I zinc metalloprotease (M18)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_638_0053"
                     /evalue="4.10E-138"
                     /label="ctg1_638"
                     /locus_tag="ctg1_638"
                     /protein_end="432"
                     /protein_start="24"
                     /score="460.9"
                     /tool="antismash"
                     /translation="FIDASPSPFHVCATVAARLIAAGYTELDEAKHWPSQPGRYFTVRA
                     GSLVAWDSTGADGPFRIVGAHTDSPNLRVKQHPDRTVAGWRVVALQPYGGAWLNSWLDR
                     DLGISGRLSVRDGSGLSHRLVRIDEPILRVPQLAIHLAEDRKSVTLDPQRHLNAVWGVG
                     ESARSFVDYVAARAAVAPGDVLAADLMTHDLTPSTLIGASENGTADLLSAPRLDNQASC
                     YAGLEALLATEPSGPLPVLVLFDHEEVGSSSDHGAHSDLLSTVLERIVLAAGGTRQDYL
                     SRLPASLLASADMAHATHPNYPERHEPGHPIAVNAGPVLKVHPNLRYATDSRTAAAFAL
                     DCRQAGVTLQRYEHRADLPCGSTIGPLAAARTGIPTVDVGAAQLAMHSARELMGAHDVA
                     AYSAAMHAF"
     CDS             8176..8523
                     /locus_tag="ctg1_639"
                     /transl_table=11
                     /translation="MGLNVEMVTFDCRDPARLAGWWAEQFGGTTHDILAGEFTAVSFPE
                     GLRLGFQKVPDPTPGKNRVHLDLGVADLDAEVSRLTAAGANEVGRHQFGESFRWVVLAD
                     PEGNVFCLVRP"
     PFAM_domain     8197..8514
                     /aSDomain="Glyoxalase_6"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF18029.3"
                     /description="Glyoxalase-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_639_0054"
                     /evalue="4.70E-28"
                     /label="ctg1_639"
                     /locus_tag="ctg1_639"
                     /protein_end="113"
                     /protein_start="7"
                     /score="98.1"
                     /tool="antismash"
                     /translation="VTFDCRDPARLAGWWAEQFGGTTHDILAGEFTAVSFPEGLRLGFQ
                     KVPDPTPGKNRVHLDLGVADLDAEVSRLTAAGANEVGRHQFGESFRWVVLADPEGNVFC
                     LV"
     CDS             complement(8524..8745)
                     /locus_tag="ctg1_640"
                     /transl_table=11
                     /translation="MTVETGHVTGTKDKNYNLIWFTEKCLDNALRLETYIQDAERDGDN
                     DVAELFRKAQSDSRKGAQMAEQLLAKRL"
ORIGIN
        1 gacaccctcg gcacgttgga gtacatcacc aaatcgggct tcgactacac ctggttcgtg
       61 ttgaacgcca agatcatcga gaaggaattc gcgctttccg gccaggagca gaaccccgac
      121 ctgaccgggc agagcgtgcg cgaactgctg cgcaaccggg cgcgctccgg gccgcccgga
      181 ccggtgcagg cgttcgtcga ccggggggtg gacttcgtca gcgcgaattc gttgcgcgag
      241 ttggtgaccg cgatgaacaa gctgcccgac gtggcgccgc tggactacgc cacggtggag
      301 gccgaggtca ccgcccgcga ccgcgaggtg gccaacaggt tcagcaagga cggccagatc
      361 accgcgatcc gcgccgcccg cggctatctg ggcgaccggc tgggccgggt ggtggcgcca
      421 caccggctga ccgacccgaa ggccggaccg ctgattgcgg tcaaactaca tatcctgacg
      481 cgaaagacgt tgggcggcat cgaaaccgac ctcgcctcgc gggtgctggg cgccgacggc
      541 accccactca ccggactgta cgcggccggc gaggcggccg gattcggcgg cggcggggtg
      601 cacggctatc gcgcgttgga aggcaccttc ctcggcgggt gcatcttctc cggccgcgct
      661 gccggtcgcg gcgtcgccga cgacatcacc taagaggccg agcgctagaa ggtgacggcg
      721 tcctcttcgg gcagcacctg gaagtcggtg ctggtcatct ccgagagccg gccgtagtag
      781 atgccgcgcg cgtccggggc gatgatgccc tggtggatgg ggacggcgcg ggcgggcgcc
      841 acggcgcgca ggtagtccac cgcctcggac accttcatcc acggggccgc ggccggggtg
      901 gccagcacgt ccaccggctc gtcgggcacg aacagcgcgt cgccgggatg catcaaccgg
      961 gcgcgatggc cgccgtcgcc caccagaaac gaaatgttct ctatcacagg gatttccggg
     1021 tggatcaccg catgtttacc gccgaccgcg cgaaccgtca gctcgccgat ctgcagctcg
     1081 tcgccgacgt gcaccgcccg gcagggtgcg cccagttggg cggtggtctg tgggtcggcg
     1141 tacagcgcgg catccgggtt accctcgagc aatgccggca gccgggtggc gtcgatgtgg
     1201 tcggggtgct gatgggtgat caagatggcg gtgaggccgg tgatgccctc gaaaccgtgt
     1261 gcgaaggtac cggggtcaaa gagcactcgg gtgtggtcga actcggcaag taggcacgaa
     1321 tggccgaaat gcgtcagttg catatctacg attgtgcctt gatggacaag ctgccgatgc
     1381 gcgtcttcct ggccaccatg gtggtcgccg gcagcttcgc ggttgccctg atcgtcgtca
     1441 tgcctgcgta cggcgagccc gagacctgcc cggggatatg cgaccggatc cccaacaccg
     1501 cgtggatcga tcagcatgcg gtgccgctgg atgcggtgta ccactggccc gcgctcgccg
     1561 gtcaggcggc gcacaccacc ggcgcggcgc ccggcccgcg tttccggttc gaggagctct
     1621 gcggcgcgcc ggccctgccg caggacccgc gcgactcggc ggtggtggcg cgttcgacgg
     1681 ttgcccatcc cgacgggcag tggcagctgc aggcgcaggt gctgcactgg cgcggcgaca
     1741 ccgcccacgg cggcgccgtc gcggccacgg tgttcggcaa cgccgtcgcc gcgctgcgcg
     1801 gctgccagca gcgcgcgccg caggaatcgc cgtcgctgac cagcgacgag ccgacccgga
     1861 tggccgccgt gatcagcggc ccggtggtga tgcacaccta tctgctggcg cacccggcca
     1921 gcagcaccat cagcgagctg acgctgtggt cgtcggcgcc gccgcagacg ccgtggccgg
     1981 cgatggcgga cgacccggtg ctgggcgcca tgaacgcgtc gttgtgcgag gcctacatcg
     2041 cctcgtgccc gtgatcccga gctgcgcttt cgccggtaga gttggcgcgg aaaacgccaa
     2101 cacaggagga gcgccggtgg cccgggtgat cgtgagtgtg atgcccaaag cggagatctt
     2161 ggacccgcag ggtcaggcga ttgtcggcgc actgggccgg ctcgggcatt ccgggatctc
     2221 agatgtgcgg cagggcaagc gatttgagct cgaggtcgat gacagcgtcg acgatgcggc
     2281 gctcgccgag atcgccgaaa cgctgttggc caacaccgtg atcgaggact ggacgatcag
     2341 ccgggagacg cagtgaccgc acgcatcggg atcatcacct tccccgggac gctcgacgac
     2401 gtggacgccg cgcgggcggc gcgacgggtc ggtgcgcagc cggtcagcct gtggcacgcc
     2461 gacgccgacc tcaagggcgt cgacgcggtg gtggtgcccg gcggcttctc ctacggcgac
     2521 tatctgcggg ccggggcgat cgcccggttc gccccggtga tggccgaagt cgtcgacgcc
     2581 gcccgccgcg gaatgccagt gttgggtatt tgcaacggtt ttcaggtgct ctgcgaggcc
     2641 gggctgctgc ccggcgcgtt gacccgcaac gtgggtctgc acttcatctg ccgcgacgtg
     2701 tggctgcggg tggcctcgac gtcgacggcg tggacgtcga ggttcgaacc cgacgccgat
     2761 ctgctggtgc cgctgaaatc cggtgagggg cgctacgtcg cccccgccga cgtgctcgac
     2821 gaactcgagg gcgagggacg ggtggtgttc cgctaccacg agaacctcaa cggttcccag
     2881 cgcgacatcg ccggcgtcag ctccgccgac ggccgtgtgg tggggctgat gccgcatccc
     2941 gaacatgcca tcgaggcgct gaccgggcct tccgacgacg gcctgggcct gttctattcg
     3001 gtgctggacg gcgtgctcgc cggctgagcg ccgggacgtc agcccgcgtc gcgcagcaat
     3061 ggtgcgtgcg ccggcggtgc ggcggggttc aactcctcga agagttcggt cgcgtccgcg
     3121 atcgtctcgt cgagaaaagc ggcgaaatcg gtgaagccga cgccgtttcg gatccattgc
     3181 gacttgcgcg ccgtgacgcc gatccgctgc ggatccgacg aaccgtgcac gatcgcggtg
     3241 acgcgccggc ccagacggtt ccaccggtcg gaaaagtggg tcagccacgg gcggtcggac
     3301 gcggggaagt agtaccccgg gctgacccgg atgatcaaca cgtcgtcgtg cgcgggcgaa
     3361 atctcgaagc ggacatgcag ccgccgcgga gcggcggtga cgaagaagta ttcgccgtcg
     3421 tggtggccgc gaaaataccg ccggccgcgc gtgcgcaagt agcgctccac caggttcgcg
     3481 cagctctgct cgttcgtcat gacgaacatg ctgccgccgg cgaatttgcg gacgctggga
     3541 gccaaccggt gcgccaccga agaatctgtt gagaattcgc tgagtcagcc actccgctcc
     3601 acgatcccgg cgccgggtcc gggcaccgtg cgcggcagcg tgaccgaaaa ccggtaccgc
     3661 tccggacgat agtggaattc caccacctcg agcggggtgt cgtcatggcc gtaactggtg
     3721 cgttcgagca ccagcaccgg cgaccccaac ggcagattca gggcgccggc cacttccacg
     3781 gaggcgccgg cggcgtggat ctcgtagctg gctcgggcga tcggggtgtc gagtcgccgc
     3841 tcccacatgg tgtaggtgct ttccatcgcc cgcccggtct gcgtgtcggt cgcgctcttc
     3901 agcaacggtt cgacggcctt gcccaacccc ggcggcaggt aggcgatcat cagggccagc
     3961 ggctgctcgc cgtcgcggaa acgccggtgc acgcaaagga ctttggtcag gtgcagcgtt
     4021 tcggcgatgc gttgcggggc gtcctcgacg cgatgcgaca gcacgtcgac gttcggggtg
     4081 atgcccgagg cggccagcac ctcggtgatg gtgcgcacgc cgggcccgag ttcctgcttg
     4141 accgggttgg ccacgaaggt gcccaggccc tggcggcgca ccagccagcc ctggcgttcg
     4201 agcagcccga ccgccgcgcg cacggtgacc cggctcaccc gggtgcgatc gaccagctct
     4261 cgctcggtgg gcagccgcgc accgcgaggc agccgctgtt tgacgatggc cgccttgagc
     4321 gcttcggcga gctgggtgct ggcgggcacg ctgccccggg agatccgcag gtcggcggcg
     4381 tcgaggtcga gctggtcggg gaccacgaga tgtattaaaa cgtctcattt gctggccgta
     4441 aagcgcgagc accgcaagca cgaccgccgt cgccagccgg gtaggcggaa atattggcgt
     4501 acaacgggtt tcgggtcgcc gtggcgtcag tcgggatcgg tcagcggata cagcgcgggc
     4561 aggttgacca cgatggcctc ctgggtgctg cgcgcgatta ccacctcggc ggtggtgtgc
     4621 gggtcggggt tttcctcccg gtgcggcagg taaggcggga tgaagacgta gtcaccgggc
     4681 gcggtggcga tgcggacttc gtggacaccg tcgtgaaaga cgaactccgg gttgccggtt
     4741 cgcacataga tcgccgtctc ggattcgccg tggtggtggt tgtccgacgc cgatccgggg
     4801 aacgcgtgcg tctcacccat ccacagcttt tccgacccga ccgagttgcc ggacagcgcg
     4861 gcgaagcgcc gcaggccctc cgactgtgcg gtatcggagc tgagctgtga cgccttgacg
     4921 tgatacacgc ggttgcgcgc gacgtgcggt gtcgcgtcgt cgaagtccgg gtgaaatccg
     4981 tccgcggtgg ccattggttc tcacgaggtg agcgggacgg cggcctcggc ggtgtagcac
     5041 aagaaggtca gcgtctcctg caggtacagc tgcacggtgt ccgcgtcgtg actggtgtag
     5101 ccgatcgaca cgtcggtccc gagttgcagg tcgaagtcgc cgccgcgggt ggtcagcacg
     5161 aaagcaccgt cgatggccgg cgcccagatg atgtcgccgg gaaccagccg gtcgatgtgt
     5221 tcgaggatcg gatagccgtg ttcggtggtc tcgctgacct tggtgtagac gtcggcggac
     5281 agcagcaccg agtaggggcc gtcgacaccg gccagccgga gttcggagat cgcctgggtg
     5341 atcacgtccg gaatctcgcg ggggtctgcc ggcagggcca gcggcttgtt cgagctggcc
     5401 gaacggatgc cgtcgatcga cgcggccgcg tagccctcga agatggcccg gtcttccacg
     5461 aacgccaact tcttggcggc ctccttgacc ggatcccagt cggagtcgtt ggcgccgcgc
     5521 tcgacgttgt cgatctcgta acgcgacaag gtgaacggaa cccgcagccg gacaaggggt
     5581 ttgctggccc gcaggtgggc caccacaccg ttggtgggtg cctcgacgtc gatcagtcgg
     5641 ccggtgctga ccgccgcggc ggccggaccg ccgggctcgc tcacgtcgac cacccgccgg
     5701 ccggcgacat ggcgcttgaa ggtccggctg gcctccaatt cgatttcacc ccaagcggct
     5761 tcggtgaccg gtgccagatc gcggtagagg ttgttcatcg agttgttcct ttcaagctgc
     5821 cgatcgacag tgagccgttc cgcgccgggg gtgccgccgg cgtcccaggc gcgggcaggg
     5881 gtggcgggtc gtcgaggaaa tcgacggtgg gagagaagaa cagtccaccg gtgaccgcgg
     5941 tggagaaatc gaggatgcga tcggtgttgc cgggcgggtc gccgaggaac atgttgcgca
     6001 gcatctgttc ggtgactcgc ggggtgcgcg agtagccgat gaaataggtg ccgtattcgc
     6061 tcttgccgag ttcgccgaag ggcatgttgt gccggacgat tttcagctcg gtgccgtcgt
     6121 cgtcggtgat gacgttgagc gcgatgtggg cgtcggcggg tttgacgtcg tcgtcgagtt
     6181 cgatgtcatc gagcttggtg cgcccgatca cgttctcctg ctcggtgacc gacagcgcgg
     6241 tccacgccga catgtcgtgc aggtacttct gcacgtggac gtagcaggag ccggcgaagt
     6301 cggggtcctc gtcgccgatc gcggtggagc tgacggccag tgcgccgtcg gggttttcgg
     6361 tgccgtcgac gaacccgagc aggtcgcggt tgtcgaagta ccggaagccg tgcacctcgt
     6421 cgacgacggt gacggcgccg gccatcgatt tcaggatccg gtcggccagt tcgaaacaga
     6481 cgtccaggct ttcggcccgg atgtggaaca acaggtcccc gggtgtggcg ggagcggtgt
     6541 gccgcggccc gtgcagctcg acgaagcggt gcagctcggc ggggcgcggc ccggagaaca
     6601 aacggtccca gacgtccgag ccgatcgagg cgatcgccga caaccgtttc tgcggctcgc
     6661 ggaaaccgat cgcgcgcacc agccccgaga tgtcctgcag cgcctcgtgc acggtcgcct
     6721 cgccgccgtc gtcgacggtc agcacgagga agatcgccgc cggggtgagc ggcgcgagga
     6781 tgggctgtgg ctggacgggg ggcacgtgga tgaccctaac gtgaacgccg tgacggcgga
     6841 cagccatgat gttcaccatg tccggcgggc ctcgaaacca gacgaagtcc tcagcgagtg
     6901 cgcaagggct ctgcgagttc atcgacgcct ctccgtcgcc gtttcacgtc tgcgccacgg
     6961 tggccgctcg gctgatcgct gccgggtaca ccgaactgga cgaggctaaa cactggccat
     7021 cgcagcccgg ccgctacttc accgtgcggg ccggctccct ggtggcctgg gattcaaccg
     7081 gcgccgacgg cccgttccgg atcgtgggcg cgcacaccga cagcccgaac ctgcgggtca
     7141 agcagcatcc cgaccggacg gtcgccgggt ggcgggtggt ggcgctgcag ccctatggcg
     7201 gcgcctggct caactcgtgg ctggaccgcg acctgggcat cagcggacgc ctgtcggtgc
     7261 gcgacggttc cgggctcagc caccggctgg tccgcatcga cgagccgatc ctgcgggtgc
     7321 cgcagctggc catccatttg gccgaggacc gcaagtcggt gacgctggat ccgcagcggc
     7381 acctcaacgc ggtgtggggc gtcggcgagt cggcgcggtc gttcgtcgac tacgtcgcgg
     7441 cacgggccgc ggtggcgccg ggcgacgtgc tggccgccga cctgatgacc cacgacctga
     7501 cgccctcgac gctgatcggc gcctcggaga acggaacggc cgacctgctc agcgcgcccc
     7561 ggctggacaa ccaggccagc tgctacgcgg gcctggaggc gctgctggcg accgagccga
     7621 gcgggccgct gcccgtcctg gtcctcttcg accacgagga ggtcgggtcg tcctcggacc
     7681 acggcgcgca ctccgacttg ttgagcaccg tgctggagcg aattgtgttg gcggccggcg
     7741 gtactcggca ggactacctg tcccggctgc cggcctcgct gctcgcctcg gcggacatgg
     7801 cacacgccac ccaccccaac tacccggagc gccacgagcc cggccacccg atcgccgtca
     7861 acgccggacc ggtgctcaag gtgcacccga acctgcgcta cgccaccgac agccgcaccg
     7921 ccgcggcctt cgcgctggac tgccggcagg ccggggtgac gctgcagcgc tacgagcacc
     7981 gggccgacct gccgtgcggg tcgacgatcg gtccgctggc cgcggcgcgc accggcatcc
     8041 cgacggtcga cgtgggcgcg gcgcagctgg cgatgcactc cgcgcgcgag ctgatgggcg
     8101 cgcacgacgt cgccgcgtac tcggccgcga tgcacgcgtt cctttctccc ggttagcggc
     8161 ataggctcgg ccggtatggg gctcaacgtg gagatggtga ccttcgactg ccgggacccc
     8221 gcgcggctgg ccggctggtg ggccgagcag ttcggcggaa cgacgcacga catcctcgcc
     8281 ggcgagttca ccgcggtgag cttccccgag gggctgcggc tggggtttca gaaggtgccc
     8341 gatcccacgc ccgggaagaa ccgcgtgcac ctcgatctcg gtgtcgccga tctcgacgcc
     8401 gaggtgtcgc ggctgacggc ggctggagcg aacgaggtcg gccggcacca gttcggtgag
     8461 agctttcgct gggtggtgct ggccgacccc gagggcaatg tgttctgcct ggtgcgcccg
     8521 tagctagagg cgcttggcca acaactgctc ggccatctgg gcgcccttgc ggctgtccga
     8581 ctgcgcttta cggaacagct cggcgacgtc gttgtccccg tcgcgctcgg cgtcctgaat
     8641 gtaggtttcc agccgcaagg cgttgtcgag acacttctcg gtgaaccaaa tgaggttgta
     8701 gttcttgtct ttggtgccgg tgacatgtcc ggtttcgact gtcattgtct cctccgtttt
     8761 gcgttcgtcc tcggacacag ggcggctacc cgcccaccct gcggacaaac cttcgccgcg
     8821 ggctggcccc ggcagcggcg ccggcagggc cggtgcgcca tagactggcg ggcgtgactg
     8881 tctccccgac gagtgcgccc acccaggcga tcgacaccgt cgagcgcgcc gcgaccaccc
     8941 ccgacgagcc gcagcccttc ggcgagttgg gcctcaaaga cgacgaatac cagcgcatcc
     9001 gcgaaatcct gggccgccgg cccaccgaca ccgagctggc gatgtactcg gtgatgtgga
     9061 gcgagcactg ctcctacaag tcgtccaagg tgcacctgcg ctacttcggg gagaccacca
     9121 ccgacgagat gcgcgccggc atgctggccg gcatcggcga gaacgccggc gtcgtcgaca
     9181 tcggcgacgg ctgggcggtc accttcaagg tggaatcgca caaccacccc tcctacgtcg
     9241 agccctatca gggggcggcc accggcgtcg gcggcatcgt gcgcgacatc atggcgatgg
     9301 gcgcgcgccc ggtggcggtg atggaccagc ttcggttcgg cgccgccgat gcgccggaca
     9361 cccgccgcgt gctcgacggc gtggtgcgcg gcatcggcgg ctacggcaac tcgctgggcc
     9421 tgcccaacat cggcggcgag accgtcttcg acgcctgcta cgccggcaac ccgctggtga
     9481 acgccatgtg cgtcggggtg ttacgccagg aggacctgca cctggccttc gcctccggca
     9541 cgggcaacaa gatcatcctg ttcggcgccc gcaccgggct ggacggcatc ggcggggtat
     9601 cggtgctggc gtcggacacc ttcgatgcgg agaactcgcg caagaagctg ccctcggttc
     9661 aggtgggcga cccgttcatg gagaaggtgc tcatcgagtg ctgcctggag ctctacgccg
     9721 gtgggctggt ggtcggtatc caagacctgg gcggtgccgg attagcttgc gccacttctg
     9781 aattggcgtc cgccggggac ggggggatgg aggtccggct ggaggccgtg ccgctgcgca
     9841 ccgccggcat gacgcccgcg gaggtgctgt gcagcgaatc ccaggagcgg atgtgcgcgg
     9901 tggtcacacc ggagaacgtc gacgccttcc tggcggtgtg ccgcaagtgg gacgtgctgg
     9961 ccaccgtgat cggcgaggtc accgacggcg accggctgcg gatcacctgg cacgggcaga
    10021 cggtggtcga cgtgccgccg cgcaccgtcg cccacgaagg cccggtgtac cagcgaccgc
    10081 tcgcccgccc cgacacccag gacgccctga acgccgacag ctcggcacgg ctgccccgcc
    10141 cggccaccgg cgccgagctg cgggccactt tgcttgcgct gcttggcagt ccgcacctgt
    10201 gcagccgcgc gttcatcacc gagcagtacg accggtatgt gcgcggcaac accgtgctgg
    10261 ccgaacacgc cgacggcggc gtgctgcgcg tcgacgagac caccggccgc ggcatcgccg
    10321 tgtccaccga cgcctcgggc cgctacacca tgctcgaccc ctacgccggt gcgcagctcg
    10381 cgctcgccga ggcctaccgc aacgtcgccg tcaccggcgc caccccggtc gcggtgacca
    10441 actgcctcaa tttcggctcg cccgaagacc ccgcggtgat gtggcagttc gcccaggcgg
    10501 tacgcgggtt ggcggatggc tgtgtggccc tggggattcc ggtgaccggc ggcaacgtca
    10561 gcttctacaa ccaaaccggg tcggcggcga tcctgcccac cccggtggtg ggagtgctcg
    10621 gcgtcctcga cgatgtgagc cgacggctgc ccaccgccct gggcgccgag cccggcgaaa
    10681 ccctgatgct gctcggcgag acccgcgacg agttcgacgg ctcggtgtgg gcacaggtga
    10741 ccgccgacca tctgggcggt ctgccgccca aggtcgacct cgcccgcgag aagctgct
//
