LOCUS       NZ_CP019962.1          16031 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP019962.1 Eubacterium limosum strain ATCC 8486 chromosome,
            complete genome.
ACCESSION   NZ_CP019962
VERSION     NZ_CP019962.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:37:01
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 471282
            Orig. end    :: 487313
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1662)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176:alkyl hydroperoxide reductase subunit (Score:
                     317.4; E-value: 2.7e-96)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_441"
                     /transl_table=11
                     /translation="MDKIYDLIIIGGGSAGLSAGIYAARAMLDTLIIEKNQPGGQAVNT
                     AEVVNYPGIRHTTGPKLMDEMHKHAMDFGAEFTVAEIEGVDLDGEVKALHTSRGTYRSR
                     AVIIATGASPRKIGFAGEQEYTGRGIAYCATCDGEFFSGLDIFVLGGGFAAAEEAVFLT
                     RYGRSVTIVVREDDFTCAQMVADKVREHPGIEVWYNTEVKEVSGDDFLKKVEFFNNKTG
                     AAFTYESKDGKPFGMFVFAGYEPATQIFKGRVDIDAEGYILTNDRMETNVPGVYAAGDL
                     RPKELRQIVTAVADGAIAATAAEKYVAAERERLGLAAPEPKAAKTPAEPETEAPQGGED
                     GFIPAAMKGQLKEIFSKLERTARVVTIIDPAVPKTLEMQGFLEEVAALNDHIQVEAYRK
                     GEKPELEAAMHLDNLPVVALFDPEGQYSGVKFTGIPGGHEMNSFVLAVYNFAGPGQAVD
                     EALAKRIAAIDHPVNAQICISLSCHFCPDVVAACQRIALLNPNIQAEMIDTALFPELKE
                     EYKLMSVPAMILNKRDVVFGAKKMSEIVEIFEKLNH"
     protocluster    1..16031
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[476931:477656]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5650..6374
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16031
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16031
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     PFAM_domain     complement(19..246)
                     /aSDomain="Thioredoxin_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13192.8"
                     /description="Thioredoxin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_441_0002"
                     /evalue="2.50E-11"
                     /label="ctg1_441"
                     /locus_tag="ctg1_441"
                     /protein_end="548"
                     /protein_start="472"
                     /score="43.6"
                     /tool="antismash"
                     /translation="NAQICISLSCHFCPDVVAACQRIALLNPNIQAEMIDTALFPELKE
                     EYKLMSVPAMILNKRDVVFGAKKMSEIVEIF"
     aSDomain        complement(19..1662)
                     /aSDomain="TIGR03143"
                     /aSTool="tigrfam"
                     /description="AhpF_homolog: putative alkyl hydroperoxide
                     reductase F subunit"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_441_0001"
                     /evalue="1.90E-244"
                     /identifier="TIGR03143"
                     /label="ctg1_441"
                     /locus_tag="ctg1_441"
                     /protein_end="548"
                     /protein_start="0"
                     /score="810.3"
                     /tool="antismash"
                     /translation="MDKIYDLIIIGGGSAGLSAGIYAARAMLDTLIIEKNQPGGQAVNT
                     AEVVNYPGIRHTTGPKLMDEMHKHAMDFGAEFTVAEIEGVDLDGEVKALHTSRGTYRSR
                     AVIIATGASPRKIGFAGEQEYTGRGIAYCATCDGEFFSGLDIFVLGGGFAAAEEAVFLT
                     RYGRSVTIVVREDDFTCAQMVADKVREHPGIEVWYNTEVKEVSGDDFLKKVEFFNNKTG
                     AAFTYESKDGKPFGMFVFAGYEPATQIFKGRVDIDAEGYILTNDRMETNVPGVYAAGDL
                     RPKELRQIVTAVADGAIAATAAEKYVAAERERLGLAAPEPKAAKTPAEPETEAPQGGED
                     GFIPAAMKGQLKEIFSKLERTARVVTIIDPAVPKTLEMQGFLEEVAALNDHIQVEAYRK
                     GEKPELEAAMHLDNLPVVALFDPEGQYSGVKFTGIPGGHEMNSFVLAVYNFAGPGQAVD
                     EALAKRIAAIDHPVNAQICISLSCHFCPDVVAACQRIALLNPNIQAEMIDTALFPELKE
                     EYKLMSVPAMILNKRDVVFGAKKMSEIVEIF"
     PFAM_domain     complement(775..1650)
                     /aSDomain="Pyr_redox_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07992.16"
                     /description="Pyridine nucleotide-disulphide
                     oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_441_0001"
                     /evalue="3.00E-42"
                     /label="ctg1_441"
                     /locus_tag="ctg1_441"
                     /protein_end="296"
                     /protein_start="4"
                     /score="145.0"
                     /tool="antismash"
                     /translation="YDLIIIGGGSAGLSAGIYAARAMLDTLIIEKNQPGGQAVNTAEVV
                     NYPGIRHTTGPKLMDEMHKHAMDFGAEFTVAEIEGVDLDGEVKALHTSRGTYRSRAVII
                     ATGASPRKIGFAGEQEYTGRGIAYCATCDGEFFSGLDIFVLGGGFAAAEEAVFLTRYGR
                     SVTIVVREDDFTCAQMVADKVREHPGIEVWYNTEVKEVSGDDFLKKVEFFNNKTGAAFT
                     YESKDGKPFGMFVFAGYEPATQIFKGRVDIDAEGYILTNDRMETNVPGVYAAGDLRPKE
                     LRQIVTAVADG"
     CDS             complement(1679..2245)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1196:alkyl hydroperoxide reductase/ Thiol specific
                     (Score: 169.7; E-value: 5.9e-52)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_442"
                     /transl_table=11
                     /translation="MKNLIGKELIDFEVQAYHEGDFKTVTKEDVLGKWGVFFFYPADFT
                     FVCPTELADVADNYEEFKKIGCEIYSVSEDTHFVHKAWADTTDTIKGLPYPMLGDPAGV
                     LAKFFGVLVKEEGQALRGTFVVDPDGVIKVYEIHDMGIGRNAEELLRKVQAAQFVREHG
                     DQVCPAKWKPGEDTLTPSLDLVGKL"
     aSDomain        complement(1682..2239)
                     /aSDomain="TIGR03137"
                     /aSTool="tigrfam"
                     /description="AhpC: peroxiredoxin"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_442_0002"
                     /evalue="6.30E-90"
                     /identifier="TIGR03137"
                     /label="ctg1_442"
                     /locus_tag="ctg1_442"
                     /protein_end="188"
                     /protein_start="2"
                     /score="297.9"
                     /tool="antismash"
                     /translation="NLIGKELIDFEVQAYHEGDFKTVTKEDVLGKWGVFFFYPADFTFV
                     CPTELADVADNYEEFKKIGCEIYSVSEDTHFVHKAWADTTDTIKGLPYPMLGDPAGVLA
                     KFFGVLVKEEGQALRGTFVVDPDGVIKVYEIHDMGIGRNAEELLRKVQAAQFVREHGDQ
                     VCPAKWKPGEDTLTPSLDLVGKL"
     PFAM_domain     complement(1697..1783)
                     /aSDomain="1-cysPrx_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10417.11"
                     /description="C-terminal domain of 1-Cys peroxiredoxin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_442_0004"
                     /evalue="5.80E-08"
                     /label="ctg1_442"
                     /locus_tag="ctg1_442"
                     /protein_end="183"
                     /protein_start="154"
                     /score="32.5"
                     /tool="antismash"
                     /translation="AAQFVREHGDQVCPAKWKPGEDTLTPSLD"
     PFAM_domain     complement(1847..2233)
                     /aSDomain="AhpC-TSA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00578.23"
                     /description="AhpC/TSA family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_442_0003"
                     /evalue="6.70E-37"
                     /label="ctg1_442"
                     /locus_tag="ctg1_442"
                     /protein_end="133"
                     /protein_start="4"
                     /score="126.2"
                     /tool="antismash"
                     /translation="IGKELIDFEVQAYHEGDFKTVTKEDVLGKWGVFFFYPADFTFVCP
                     TELADVADNYEEFKKIGCEIYSVSEDTHFVHKAWADTTDTIKGLPYPMLGDPAGVLAKF
                     FGVLVKEEGQALRGTFVVDPDGVIK"
     CDS             complement(2435..3403)
                     /gene_functions="transport (smcogs) SMCOG1166:transporter,
                     EamA family (Score: 138.8; E-value: 3.9e-42)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_443"
                     /transl_table=11
                     /translation="LKKGYLYIVIATLFFSSMEIALKSVSGQFNAVQMNLTRFLIGGLV
                     LIPFALRTLKKKKEHLDKKSLLHFAGLGFLGVVVSMTFYQLAVENANASVVAVLFSSNP
                     VFVLFFSGIILHEVIKKNHVAAIVLEIIGILVIVNPLHTALNIAGVVMAILAAVAFALY
                     SVFSKKQCNRYGGVVVTCGSFLFASLEMLLLIGLSHVGPVADMLSGSGLALFANIPLFT
                     GYTASNVLTMLYICIGVTGGGYAFYFMAIEETSASTASLVFFFKPVLSPILAVLILHEA
                     VPINMVIGVLLILAGSIANLLPAFIHREEKPVSLSAEQGRS"
     PFAM_domain     complement(2510..2959)
                     /aSDomain="EamA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00892.22"
                     /description="EamA-like transporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_443_0006"
                     /evalue="5.20E-18"
                     /label="ctg1_443"
                     /locus_tag="ctg1_443"
                     /protein_end="298"
                     /protein_start="148"
                     /score="65.6"
                     /tool="antismash"
                     /translation="GVVMAILAAVAFALYSVFSKKQCNRYGGVVVTCGSFLFASLEMLL
                     LIGLSHVGPVADMLSGSGLALFANIPLFTGYTASNVLTMLYICIGVTGGGYAFYFMAIE
                     ETSASTASLVFFFKPVLSPILAVLILHEAVPINMVIGVLLILAGSI"
     PFAM_domain     complement(2990..3397)
                     /aSDomain="EamA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00892.22"
                     /description="EamA-like transporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_443_0005"
                     /evalue="3.20E-25"
                     /label="ctg1_443"
                     /locus_tag="ctg1_443"
                     /protein_end="138"
                     /protein_start="2"
                     /score="89.0"
                     /tool="antismash"
                     /translation="KGYLYIVIATLFFSSMEIALKSVSGQFNAVQMNLTRFLIGGLVLI
                     PFALRTLKKKKEHLDKKSLLHFAGLGFLGVVVSMTFYQLAVENANASVVAVLFSSNPVF
                     VLFFSGIILHEVIKKNHVAAIVLEIIGILVIV"
     CDS             complement(3501..4385)
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 175.6; E-value: 2.1e-53)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_444"
                     /transl_table=11
                     /translation="MNVNFEHYKVFYYVARHGTITQAAQALYISQPAVSKSIHLLEKEL
                     SCELFHRNQKGMTLTPEGEMLYGHVAKAYEQLALGEKKLWEMLNLNNGVVRLGTSDMIA
                     RFFLLPYLEKFHSLYPDIRINMQSGTTPGTRVALKEERIEVGVVSSPVAASDDIEIHPI
                     REIQDVFVAGLDYAPLAEKVLSFEEIMAHPIICTERNTASRHYLDSFFLKHKIRLEPAF
                     ELGTMELIMPYAERNLGIGIAVRDVAQERLEQGSLIEIRAKIEMPKRQICVIKRKKGGI
                     SKAAEAFLDIILP"
     PFAM_domain     complement(3510..4112)
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_444_0008"
                     /evalue="1.90E-32"
                     /label="ctg1_444"
                     /locus_tag="ctg1_444"
                     /protein_end="292"
                     /protein_start="91"
                     /score="112.4"
                     /tool="antismash"
                     /translation="NGVVRLGTSDMIARFFLLPYLEKFHSLYPDIRINMQSGTTPGTRV
                     ALKEERIEVGVVSSPVAASDDIEIHPIREIQDVFVAGLDYAPLAEKVLSFEEIMAHPII
                     CTERNTASRHYLDSFFLKHKIRLEPAFELGTMELIMPYAERNLGIGIAVRDVAQERLEQ
                     GSLIEIRAKIEMPKRQICVIKRKKGGISKAAEAFLDII"
     PFAM_domain     complement(4194..4370)
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_444_0007"
                     /evalue="1.80E-20"
                     /label="ctg1_444"
                     /locus_tag="ctg1_444"
                     /protein_end="64"
                     /protein_start="5"
                     /score="72.8"
                     /tool="antismash"
                     /translation="EHYKVFYYVARHGTITQAAQALYISQPAVSKSIHLLEKELSCELF
                     HRNQKGMTLTPEGE"
     CDS             4764..5102
                     /locus_tag="ctg1_445"
                     /transl_table=11
                     /translation="MQELDHKAIGLRIRKQRTFLNMSRDELARKIGITPTFLADIELGT
                     KGFSLKSLNRFCDVLKMSADAILYGPKEYMGTKYAALLELLERCPAEKGKYAEEILTLF
                     LLSHDPVE"
     PFAM_domain     4800..4958
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_445_0009"
                     /evalue="3.70E-07"
                     /label="ctg1_445"
                     /locus_tag="ctg1_445"
                     /protein_end="65"
                     /protein_start="12"
                     /score="30.2"
                     /tool="antismash"
                     /translation="IRKQRTFLNMSRDELARKIGITPTFLADIELGTKGFSLKSLNRFC
                     DVLKMSAD"
     CDS             complement(5139..5606)
                     /locus_tag="ctg1_446"
                     /transl_table=11
                     /translation="MECGFDVSPYITEAFTPEQIREIFWGLMTGVDVTFYNDPEYSNCQ
                     MWQIREGLTGKVDVSIYADKNLDWKKMYLIRMGLEEGLDVSEYVRQGMGPEQIRAILQG
                     YRTDIDYTLYAKPWYTAGEMREIGSKLIREAVRSRAEETPGAGSMFKSVKK"
     CDS             complement(5650..6225)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_447"
                     /sec_met_domain="AgrB (E-value: 1.8e-37, bitscore: 126.4,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEKASDALIYQLKRREIVVDEDVEIYQFGIRVLMLKAVHYASML
                     LVGLLLGMLPETIVFLIVYAAIRAYAGGYHADTRGVCYLLSWITILSVLLIARFCPAGT
                     VAVVTAALTLSAFPVIYKWAPVENSAKPLDDAECTHYRKRARRILVVISACALLAGLAF
                     NSRFGLVAAECLGLEALMMLLGLWKNGR"
     PFAM_domain     complement(5731..6207)
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_447_0010"
                     /evalue="4.10E-37"
                     /label="ctg1_447"
                     /locus_tag="ctg1_447"
                     /protein_end="165"
                     /protein_start="6"
                     /score="127.4"
                     /tool="antismash"
                     /translation="DALIYQLKRREIVVDEDVEIYQFGIRVLMLKAVHYASMLLVGLLL
                     GMLPETIVFLIVYAAIRAYAGGYHADTRGVCYLLSWITILSVLLIARFCPAGTVAVVTA
                     ALTLSAFPVIYKWAPVENSAKPLDDAECTHYRKRARRILVVISACALLAGLAFNS"
     CDS             complement(6225..6374)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_448"
                     /sec_met_domain="TIGR04223 (E-value: 2.1e-09, bitscore:
                     35.2, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKDSFKNKILKNVAKVAHHEAVKDANTACWMIHHQEKAPVNIKK
                     LRKF"
     aSDomain        complement(6240..6353)
                     /aSDomain="TIGR04223"
                     /aSTool="tigrfam"
                     /description="quorum_AgrD: cyclic lactone autoinducer
                     peptide"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_448_0003"
                     /evalue="2.30E-09"
                     /identifier="TIGR04223"
                     /label="ctg1_448"
                     /locus_tag="ctg1_448"
                     /protein_end="45"
                     /protein_start="7"
                     /score="35.2"
                     /tool="antismash"
                     /translation="NKILKNVAKVAHHEAVKDANTACWMIHHQEKAPVNIKK"
     CDS             complement(6534..7766)
                     /locus_tag="ctg1_449"
                     /transl_table=11
                     /translation="MFRFMSEVYDRKYKEKFNYFISFLLFVIIAIGLNILGIPILKITF
                     LLLSLCLVSYSLFIFDKKWMLIYDFVFALYIIFSDVISVVIVSLIMDTTIEGVEESFNF
                     LFLSGICNQIILLCGFYIFVSIFKKNELNTLKIVQNIFLMLLAVFEISVLYYFYITIQQ
                     SSSGIALAYICFGFIGLDIYLVYLFEAISKRYQLERDMDLKEQQVMMQNTYYKSIEAQY
                     DYSRRLIHDMKNHMQTFEELYANDNGDMAHSYARTIYRKMDELGSRFKCSNRFLTIIIN
                     NKLIKCDENSIDVMLEVEDIDIGFMDFFDVTTIFSNLLDNAIDACLELPIDKRHISLRI
                     FKFNDFITVVICNSYNGKVNNKNNELKSTKQGEHMGVGLKNVKTAIEKYNGTIQYKIEE
                     EFKVKILISAS"
     PFAM_domain     complement(6546..6845)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_449_0011"
                     /evalue="8.90E-21"
                     /label="ctg1_449"
                     /locus_tag="ctg1_449"
                     /protein_end="407"
                     /protein_start="307"
                     /score="73.8"
                     /tool="antismash"
                     /translation="FFDVTTIFSNLLDNAIDACLELPIDKRHISLRIFKFNDFITVVIC
                     NSYNGKVNNKNNELKSTKQGEHMGVGLKNVKTAIEKYNGTIQYKIEEEFKVKILI"
     CDS             complement(7862..8581)
                     /locus_tag="ctg1_450"
                     /transl_table=11
                     /translation="MIRIGICDDNALIAEKLEALIIRYGEEHNIDVETYVYHDGSEVLE
                     DRIQFDILFLDVEMPETDGIDTAKQIRKWDARVKIIFITSYTHYMRNAFAVHAFEYLVK
                     PFNTAKVNMVLTEVFDFIEKENKSHDISLVMGGELKVFASNDIYYFERVRRKIKMSTTQ
                     GDFEFSGVLSEIMEKVKDFDFEYCHKSVIVNLFHCKRIAGADLYLDNGETLPIAQKRAV
                     EFKARLFDYIEENFKLL"
     PFAM_domain     complement(7898..8164)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_450_0013"
                     /evalue="1.00E-14"
                     /label="ctg1_450"
                     /locus_tag="ctg1_450"
                     /protein_end="228"
                     /protein_start="139"
                     /score="54.6"
                     /tool="antismash"
                     /translation="KVFASNDIYYFERVRRKIKMSTTQGDFEFSGVLSEIMEKVKDFDF
                     EYCHKSVIVNLFHCKRIAGADLYLDNGETLPIAQKRAVEFKARL"
     PFAM_domain     complement(8249..8569)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_450_0012"
                     /evalue="4.00E-17"
                     /label="ctg1_450"
                     /locus_tag="ctg1_450"
                     /protein_end="111"
                     /protein_start="4"
                     /score="62.5"
                     /tool="antismash"
                     /translation="GICDDNALIAEKLEALIIRYGEEHNIDVETYVYHDGSEVLEDRIQ
                     FDILFLDVEMPETDGIDTAKQIRKWDARVKIIFITSYTHYMRNAFAVHAFEYLVKPFNT
                     AKV"
     CDS             complement(9184..10575)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 335.6; E-value: 6.5e-102)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_451"
                     /sec_met_domain="Polysacc_synt (E-value: 9.3e-06, bitscore:
                     23.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEETREIPLKGQMTEGKIGRQLLLFALPLMFSNLCQQLYNTVDAV
                     IVGRFVGANALAAVGASSLLITFMIYFFIGLSIGASVLISQFFGSRKYDKVQEAVHTAV
                     ALSLAAGLALTVLGLAFAPAMLRMMNIPEAGLAYAVPYIRIYFLGMIPMTLYNIGSGIL
                     RAVGDSKTPLACLVVTVVLNIGLDLLFVGPLGMGVAGAALATVFSQMAAAVLIVIILLR
                     ADPIYRLRLAKIRFHAQVFRDIVRIGLPAGLQSVLVCFSNVVVQSQINTFGLEVMAGFT
                     AYMKIDGFLFMPIDAFCLAISSFVGQNMGAGRWERVVKGKNVCLLLCVGVTIGLGAAII
                     LNARLILGMFTSDETVVLNGMRQLYTVVPLYGIYAADQVFVGVLRGAGATVIPMIITLL
                     CMCGLRLGWIFTTLRFVHDARMIYISYPLTWIVTGAVLVLYYYKGSWRPEKAGFNNRKY
                     LKRSC"
     aSDomain        complement(9343..10494)
                     /aSDomain="TIGR00797"
                     /aSTool="tigrfam"
                     /description="matE: MATE efflux family protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_451_0004"
                     /evalue="6.90E-74"
                     /identifier="TIGR00797"
                     /label="ctg1_451"
                     /locus_tag="ctg1_451"
                     /protein_end="411"
                     /protein_start="27"
                     /score="247.0"
                     /tool="antismash"
                     /translation="PLMFSNLCQQLYNTVDAVIVGRFVGANALAAVGASSLLITFMIYF
                     FIGLSIGASVLISQFFGSRKYDKVQEAVHTAVALSLAAGLALTVLGLAFAPAMLRMMNI
                     PEAGLAYAVPYIRIYFLGMIPMTLYNIGSGILRAVGDSKTPLACLVVTVVLNIGLDLLF
                     VGPLGMGVAGAALATVFSQMAAAVLIVIILLRADPIYRLRLAKIRFHAQVFRDIVRIGL
                     PAGLQSVLVCFSNVVVQSQINTFGLEVMAGFTAYMKIDGFLFMPIDAFCLAISSFVGQN
                     MGAGRWERVVKGKNVCLLLCVGVTIGLGAAIILNARLILGMFTSDETVVLNGMRQLYTV
                     VPLYGIYAADQVFVGVLRGAGATVIPMIITLLCMCGLRLGWIFT"
     PFAM_domain     complement(9361..9828)
                     /aSDomain="MatE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01554.20"
                     /description="MatE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_451_0015"
                     /evalue="2.00E-22"
                     /label="ctg1_451"
                     /locus_tag="ctg1_451"
                     /protein_end="405"
                     /protein_start="249"
                     /score="79.6"
                     /tool="antismash"
                     /translation="PAGLQSVLVCFSNVVVQSQINTFGLEVMAGFTAYMKIDGFLFMPI
                     DAFCLAISSFVGQNMGAGRWERVVKGKNVCLLLCVGVTIGLGAAIILNARLILGMFTSD
                     ETVVLNGMRQLYTVVPLYGIYAADQVFVGVLRGAGATVIPMIITLLCMCGLR"
     PFAM_domain     complement(10015..10494)
                     /aSDomain="MatE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01554.20"
                     /description="MatE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_451_0014"
                     /evalue="4.00E-35"
                     /label="ctg1_451"
                     /locus_tag="ctg1_451"
                     /protein_end="187"
                     /protein_start="27"
                     /score="121.0"
                     /tool="antismash"
                     /translation="PLMFSNLCQQLYNTVDAVIVGRFVGANALAAVGASSLLITFMIYF
                     FIGLSIGASVLISQFFGSRKYDKVQEAVHTAVALSLAAGLALTVLGLAFAPAMLRMMNI
                     PEAGLAYAVPYIRIYFLGMIPMTLYNIGSGILRAVGDSKTPLACLVVTVVLNIGLD"
     CDS             complement(10590..11546)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 207.8; E-value:
                     3.1e-63)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_452"
                     /transl_table=11
                     /translation="LSENHEIILETRGLTKRFHTSDGRPLTACDSISLAARRGETLGIV
                     GESGCGKSTFVKMLVQLEKPTAGAIYFRGKDIAGLSGEEARRKRQHIQMVFQDPAASFS
                     PKMRVGDIITEPLVNFGRLLRKQRSEKARELLEMVELDADFMQRYPHSMSGGQLQRVGI
                     ARALALNPEVLVCDEATSALDVSIQKKIVALLTRLQKEKNIAMIFICHDMALVQSLSHR
                     LAVMYLGNIVETVGGGELCETAMHPYTQALLGSVFSLHMDCCKKIETIPGDPPSPLELP
                     PGCPFAGRCEKRMPVCKAEKPRLKDVAPGHQVACHLY"
     aSDomain        complement(10596..10856)
                     /aSDomain="TIGR01727"
                     /aSTool="tigrfam"
                     /description="oligo_HPY: oligopeptide/dipeptide ABC
                     transporter, ATP-binding protein, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_452_0005"
                     /evalue="1.40E-21"
                     /identifier="TIGR01727"
                     /label="ctg1_452"
                     /locus_tag="ctg1_452"
                     /protein_end="317"
                     /protein_start="230"
                     /score="74.3"
                     /tool="antismash"
                     /translation="IVETVGGGELCETAMHPYTQALLGSVFSLHMDCCKKIETIPGDPP
                     SPLELPPGCPFAGRCEKRMPVCKAEKPRLKDVAPGHQVACHL"
     PFAM_domain     complement(10656..10850)
                     /aSDomain="oligo_HPY"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08352.14"
                     /description="Oligopeptide/dipeptide transporter,
                     C-terminal region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_452_0017"
                     /evalue="1.20E-13"
                     /label="ctg1_452"
                     /locus_tag="ctg1_452"
                     /protein_end="297"
                     /protein_start="232"
                     /score="51.5"
                     /tool="antismash"
                     /translation="ETVGGGELCETAMHPYTQALLGSVFSLHMDCCKKIETIPGDPPSP
                     LELPPGCPFAGRCEKRMPVC"
     PFAM_domain     complement(11004..11459)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_452_0016"
                     /evalue="4.00E-33"
                     /label="ctg1_452"
                     /locus_tag="ctg1_452"
                     /protein_end="181"
                     /protein_start="29"
                     /score="114.9"
                     /tool="antismash"
                     /translation="DSISLAARRGETLGIVGESGCGKSTFVKMLVQLEKPTAGAIYFRG
                     KDIAGLSGEEARRKRQHIQMVFQDPAASFSPKMRVGDIITEPLVNFGRLLRKQRSEKAR
                     ELLEMVELDADFMQRYPHSMSGGQLQRVGIARALALNPEVLVCDEATS"
     CDS             complement(11539..12324)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 193.4; E-value:
                     7.6e-59)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_453"
                     /transl_table=11
                     /translation="MLKIRDMSVQYGEKPPAVAHFDLHMKKHEIISVVGESGSGKTTVI
                     RSILGLLPGNGRVTGGEILFDEEPLLQKTPEDWRDLRGSRIAMIFQDSGSTLNPIRKIG
                     RQFVNYIQTHKAVTRDSARDRAVEMLTRMRLPDAGNIMDSYPFQLSGGMRQRVGIAMAM
                     AFEPDLLLADEPTSALDVTTQAQIVRQMMALRQNFGTGIMIVTHNLGVAAYMADRIIVM
                     RAGEIVESGTREEVILHPRQEYTKELVAAVPELGGARFV"
     PFAM_domain     complement(11794..12264)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_453_0018"
                     /evalue="5.90E-26"
                     /label="ctg1_453"
                     /locus_tag="ctg1_453"
                     /protein_end="177"
                     /protein_start="20"
                     /score="91.7"
                     /tool="antismash"
                     /translation="FDLHMKKHEIISVVGESGSGKTTVIRSILGLLPGNGRVTGGEILF
                     DEEPLLQKTPEDWRDLRGSRIAMIFQDSGSTLNPIRKIGRQFVNYIQTHKAVTRDSARD
                     RAVEMLTRMRLPDAGNIMDSYPFQLSGGMRQRVGIAMAMAFEPDLLLADEPTS"
     CDS             complement(12353..13921)
                     /gene_functions="transport (smcogs) SMCOG1068:extracellular
                     solute-binding protein family 5 (Score: 343.8; E-value:
                     3.2e-104)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_454"
                     /transl_table=11
                     /translation="MSKFKKLVLTVAILAMTATGLSGCGGSGGASGSSEQLNIGVTSFA
                     DTLEPTEQYFSWVVMRYGVGETLVKFNDEMGAEPWLAESWELGSDNLTWTFKIRDGVKF
                     SNGTALTADLVKASLERTFEMSKRASSDFFQYDAMTAEGSNLIIKTKSPTPGLPGCLAD
                     PLFLIVDTTVDTSTFATDGPICTGPYAVKSFDKEKCVVVKNENYWDGEVPYNEVNIQVI
                     DDANTRAMALQSGEVDMAVNISSSDLALFEGSESFDINSIASLRTVLSFMNQRGPLADV
                     KVRQAVIRALDRQTYADNLLHGTFEAGKAPIPPSLDYGFDTLKDENAYNLESAKQLLAE
                     AGYADTNGDGIVEKDGQNLTLQYVIYDSRAELPILATATQANLKEIGIDVKVETYEYTT
                     LLDMQENGEYDLLIWNVITANTGDPENYLKEYWKTHTDENKNANTAGYSNPEVDAVLDQ
                     LSTEFDTAKRRELVIRAQQLIMNDAASVFYAYPETNIISSKKITGVEMLPADYYWLTKE
                     IKPAQ"
     PFAM_domain     complement(12620..13690)
                     /aSDomain="SBP_bac_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00496.24"
                     /description="Bacterial extracellular solute-binding
                     proteins, family 5 Middle"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_454_0019"
                     /evalue="3.20E-85"
                     /label="ctg1_454"
                     /locus_tag="ctg1_454"
                     /protein_end="434"
                     /protein_start="77"
                     /score="286.5"
                     /tool="antismash"
                     /translation="EPWLAESWELGSDNLTWTFKIRDGVKFSNGTALTADLVKASLERT
                     FEMSKRASSDFFQYDAMTAEGSNLIIKTKSPTPGLPGCLADPLFLIVDTTVDTSTFATD
                     GPICTGPYAVKSFDKEKCVVVKNENYWDGEVPYNEVNIQVIDDANTRAMALQSGEVDMA
                     VNISSSDLALFEGSESFDINSIASLRTVLSFMNQRGPLADVKVRQAVIRALDRQTYADN
                     LLHGTFEAGKAPIPPSLDYGFDTLKDENAYNLESAKQLLAEAGYADTNGDGIVEKDGQN
                     LTLQYVIYDSRAELPILATATQANLKEIGIDVKVETYEYTTLLDMQENGEYDLLIWNVI
                     TANTGDPENYLKEYWKT"
     CDS             complement(14244..15062)
                     /gene_functions="transport (smcogs)
                     SMCOG1085:binding-protein-dependent transport systems
                     (Score: 295.4; E-value: 5.5e-90)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_455"
                     /transl_table=11
                     /translation="MKAFFRQNRLFAICGILAAAIVLTAVFAPWIAPHDPYEAVMQNAL
                     RAPSAEYPCGTDQLGRCELSRIIYGTRASLEMTVTLVVIVFAAGTLLGMIAGYFGGAAD
                     AVIMRLSDMMIAFPGMVLAIAIAGMLGPSLFNTVIALAVVSWTKYARLSRSLVLKIKNS
                     TYISAAVVTGARTGHILGGYVVPNIIPTMIVTAALDVGTMMLELAALSFLGLGAQPPTP
                     EWGLMLNEGRQYLQTAPWLMLFPGIAIFIVVSVFNLMGDGLRDILDPRQD"
     PFAM_domain     complement(14253..14798)
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00528.24"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_455_0021"
                     /evalue="2.80E-28"
                     /label="ctg1_455"
                     /locus_tag="ctg1_455"
                     /protein_end="270"
                     /protein_start="88"
                     /score="99.0"
                     /tool="antismash"
                     /translation="GTLLGMIAGYFGGAADAVIMRLSDMMIAFPGMVLAIAIAGMLGPS
                     LFNTVIALAVVSWTKYARLSRSLVLKIKNSTYISAAVVTGARTGHILGGYVVPNIIPTM
                     IVTAALDVGTMMLELAALSFLGLGAQPPTPEWGLMLNEGRQYLQTAPWLMLFPGIAIFI
                     VVSVFNLMGDGLRDILDPR"
     PFAM_domain     complement(14928..15050)
                     /aSDomain="OppC_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12911.9"
                     /description="N-terminal TM domain of oligopeptide
                     transport permease C"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_455_0020"
                     /evalue="2.50E-07"
                     /label="ctg1_455"
                     /locus_tag="ctg1_455"
                     /protein_end="45"
                     /protein_start="4"
                     /score="30.6"
                     /tool="antismash"
                     /translation="FRQNRLFAICGILAAAIVLTAVFAPWIAPHDPYEAVMQNAL"
     CDS             complement(15063..16031)
                     /gene_functions="transport (smcogs)
                     SMCOG1118:binding-protein-dependent transport systems
                     (Score: 364.5; E-value: 6.8e-111)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_456"
                     /transl_table=11
                     /translation="LNTKQLVNRLLQIVLVLFGISFLTFCLTYLSPGDPAELMLVEGGT
                     VPSEELLAETREQMGLNDPFLVQYGNWLKGFVTGDMGTSYSSKAPVSAVLLDCLGPTLE
                     LAAASLILMLVISIPLGILAAVYQNKFPDYLVRGLSFAGVSFPGFWIGLVLLYVFGLKL
                     NWFPIATSGTGFMKLVLPAVTLAIAMSAKYTRQVRTAVLEELRQDYVAGARARGLKESA
                     ILWREVLPNAMLPLVTLLGLSLGSLLGGTAVVEIIFSWPGLGKMAVNAIATRDYPLVQG
                     YVIWIALIYMVINLLVDFSYGYLDPRLRERHREAKRKVVKA"
     PFAM_domain     complement(15105..15680)
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00528.24"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_456_0023"
                     /evalue="4.00E-48"
                     /label="ctg1_456"
                     /locus_tag="ctg1_456"
                     /protein_end="309"
                     /protein_start="117"
                     /score="163.7"
                     /tool="antismash"
                     /translation="IPLGILAAVYQNKFPDYLVRGLSFAGVSFPGFWIGLVLLYVFGLK
                     LNWFPIATSGTGFMKLVLPAVTLAIAMSAKYTRQVRTAVLEELRQDYVAGARARGLKES
                     AILWREVLPNAMLPLVTLLGLSLGSLLGGTAVVEIIFSWPGLGKMAVNAIATRDYPLVQ
                     GYVIWIALIYMVINLLVDFSYGYLDPRLR"
     PFAM_domain     complement(15774..16022)
                     /aSDomain="BPD_transp_1_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19300.1"
                     /description="Binding-prot-dependent transport system
                     membrane comp, N-term"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_456_0022"
                     /evalue="1.10E-13"
                     /label="ctg1_456"
                     /locus_tag="ctg1_456"
                     /protein_end="86"
                     /protein_start="3"
                     /score="51.4"
                     /tool="antismash"
                     /translation="KQLVNRLLQIVLVLFGISFLTFCLTYLSPGDPAELMLVEGGTVPS
                     EELLAETREQMGLNDPFLVQYGNWLKGFVTGDMGTSYS"
ORIGIN
        1 ttaatgattt agtttttcaa aaatttcgac aatctcgctc attttctttg cgccgaagac
       61 cacatcccgt ttattgagga tcatggcagg tacgctcatg agcttgtatt cttccttcag
      121 ctctgggaaa agggccgtgt cgatcatttc cgcctgaatg ttcgggttca gtagagcgat
      181 gcgttggcag gccgccacca catcggggca gaaatgacag gacagggaga tacagatctg
      241 ggcattaact ggatggtcga tggccgcaat ccgcttggca agggcctcgt ccactgcctg
      301 gcccggtccg gcgaagttat aaaccgccag aacaaaggaa ttcatttcat ggccgccggg
      361 gataccggta aatttgacgc cggaatactg tccctctgga tcaaacaggg ctaccaccgg
      421 caggttgtcg aggtgcatgg cggcttccag ctcaggcttc tcgccttttc tataggcctc
      481 cacctggata tggtcgttaa gcgctgccac ttcctctaag aaaccctgca tttccaaggt
      541 ctttggcaca gccgggtcga tgatggtcac cacccgcgca gtgcgttcga gcttgctgaa
      601 gatttccttg agctggccct tcatggccgc cgggataaag ccgtcttcgc cgccctgtgg
      661 cgcttccgtc tccggctctg ccggagtttt ggctgccttc ggctcaggcg ctgccaggcc
      721 caggcgttcc cgctcagccg ccacgtattt ttccgccgcg gtggccgcga tggcgccgtc
      781 ggccactgcc gtgacaatct ggcgcagctc ctttggcctc aggtcacccg cggcgtaaac
      841 gccggggaca ttggtttcca tgcggtcatt tgtgaggata tagccctcag cgtcgatgtc
      901 cacccggccc ttaaaaatct gggtggccgg ctcatagccc gcgaacacaa acatgccaaa
      961 aggcttgccg tccttgctct cataggtaaa ggcagcgccg gtcttattat tgaaaaattc
     1021 tacctttttc agaaaatcgt cgccggaaac ttctttcacc tctgtgttgt accacacctc
     1081 aatgcccgga tgttcccgga ccttgtccgc caccatctgg gcgcaggtaa aatcatcctc
     1141 gcgcaccaca atggtcacgc ttctgccgta gcgggtcagg aacacagcct cctcggctgc
     1201 ggcaaagccg ccgcccagca caaagatgtc aaggccgctg aaaaactcgc cgtcacaggt
     1261 cgcgcagtag gcaatgccgc gtccggtata ttcctgctca ccggcaaagc cgatcttgcg
     1321 cggggaggcg cctgtggcga tgatgaccgc gcggcttctg taagtgccgc ggctggtatg
     1381 cagtgccttt acttccccgt caaggtccac cccctcgatc tcagctacag taaattccgc
     1441 gccgaaatcc atggcgtgct tgtgcatttc atccatgagc ttagggccgg tggtgtggcg
     1501 gataccggga tagttaacta cctccgcggt attcacagcc tggccgcccg gctggttttt
     1561 ctcaatgatc agcgtatcga gcatggcccg ggcagcatag ataccagccg agagtccggc
     1621 ggaaccgccg ccgataataa tcaagtcata aatcttatcc atggcgccct cctgcttctt
     1681 acagcttgcc gactaagtct aagcttggtg tcagtgtgtc ttcgcctggt ttccatttcg
     1741 cagggcagac ctgatcgccg tgttctctta caaactgagc ggcctgtacc ttgcgcagaa
     1801 gctcctcagc gttacggccg atgcccatgt catgaatttc gtaaaccttg ataacgccgt
     1861 ccgggtccac cacaaaggta ccgcgcagcg cctggccttc ttccttgacc agcacaccga
     1921 agaattttgc cagcacgccc gccgggtcgc ctaacatcgg gtacggaagg cccttgatgg
     1981 tgtcggtggt gtccgcccag gctttatgta caaaatgggt atcttctgaa accgaataga
     2041 tttcacagcc gatttttttg aactcctcat aattgtccgc tacgtccgcc aactctgtcg
     2101 ggcacacaaa ggtaaaatct gccgggtaaa agaagaacac accccatttg cccaggacat
     2161 cttcctttgt gacggtttta aaatcacctt cgtgatatgc ctgtacttca aaatcgatca
     2221 attctttgcc aattaaattt ttcatgttga tacctctttt cgataatatt tatttttgtt
     2281 agttatttct aactgtttga tgagtgtatc ttaacacgat aaaatggact tgtcaagaat
     2341 aattctaaat taaaaagcag atttttaaca aaaaaagcca cagagatttt aagggattct
     2401 ctgtggcttc aacaatcaaa ttttataaaa caggctaaga acggccctgc tccgcactca
     2461 gggacacagg cttttcttcc ctgtgtataa acgccggcag caggttcgcg atagagcccg
     2521 ccagaatcag cagcacaccg atcaccatgt tgatcggcac tgcttcgtgc aggatcagca
     2581 ctgcaaggat gggcgacagc accggtttaa agaagaacac cagcgacgcc gtactggccg
     2641 aggtctcctc aatcgccatg aaataaaagg cataaccacc gccagtcacg ccgatacaga
     2701 tataaagcat cgtgaggaca ttagacgccg tataacccgt aaacagcgga atattggcaa
     2761 ataaggcaag accgctgccg ctcagcatat ccgccaccgg gcccacatgg ctgaggccga
     2821 tgagcagcag catttccagg ctggcgaaca gaaagctccc gcaggtcacc accacgccgc
     2881 cgtagcggtt acactgcttc ttggaaaaaa ctgagtacag ggcaaaagcc accgcggcca
     2941 gaatcgccat gaccacccct gcgatgttga gggcggtgtg cagagggttg acaattacca
     3001 ggattccgat gatttcaagc acaatggccg ccacatggtt tttcttgatc acctcgtgca
     3061 ggataatgcc cgagaaaaac agcacaaaca ccggattact ggaaaacagc accgccacca
     3121 ccgaggcgtt ggcgttttct accgccagct ggtaaaaggt catgctgacc acaaccccca
     3181 gaaagcccag gcccgcgaaa tgcagcaggc tttttttatc cagatgttcc tttttcttct
     3241 taagcgtcct gagcgcaaag ggaattaaaa caagaccgcc gatcaaaaaa cgggtcaggt
     3301 tcatctgtac agcgttaaac tgacctgaaa cacttttgag ggcgatctcc atcgaactga
     3361 aaaacagcgt cgcaatgaca atatataaat agcctttttt caaaatcaaa tcttcctttc
     3421 atttttcgta cagtaacgat tttacctctc tcattaccat aagtaaaatg aaatattctt
     3481 atgtgcttta taaccgttgg ttatggcaaa ataatatcca gaaaagcctc tgccgccttg
     3541 gagataccgc cttttttccg cttgatcaca cagatctgcc gcttcggcat ctcaatctta
     3601 gcccggatct cgatcaggct cccctgctcc aggcgctcct gtgctacatc gcgcaccgcg
     3661 atgcctatac ccaggtttct ttctgcgtaa ggcatgatca gctccatggt gcccagttca
     3721 aaggccggct ccagccgtat cttatgcttg aggaaaaacg agtccaaata gtgccggctg
     3781 gccgtgttgc gctccgtaca gataatgggg tgcgccatga tctcctcaaa gctcagcacc
     3841 ttttcggcaa gcggcgcgta atccagcccc gccacaaaaa catcctggat ctcccggatc
     3901 gggtgaatct caatatcgtc tgaggccgcc actggcgagg ataccactcc cacctcaatg
     3961 cgctcctctt tcagggcaac gcgtgtgccc ggcgtggtgc cgctctgcat attgatgcgg
     4021 atatccggat acaggctgtg aaatttttca agataaggca gcaggaaaaa gcgggcgatc
     4081 atgtcactag tgcccaggcg caccacccca ttattcagat tcagcatttc ccagagcttc
     4141 ttttcgccta gggccagctg ctcataggcc tttgccacat ggccgtacag catttccccc
     4201 tccggcgtca gggtcattcc cttctgattc cggtgaaaaa gctcgcacga cagctccttt
     4261 tccagcaggt ggatcgattt gctcaccgcc ggctgcgaga tgtacagcgc ctgggccgcc
     4321 tgtgtaatgg tgccgtggcg cgctacgtaa taaaagacct tgtaatgttc aaaatttaca
     4381 ttcataaaaa tacgtccttt ttccgttaat ccgtttcatt atatcacatt ttgaatttta
     4441 tgcaacctgc ccattcttcg actttctgtc acgattaatt tgcctaaaag tacgagaatt
     4501 tttcaactta aaatatttta gacaaacaaa aaaatccccc tgcgcctgtc tttgggagag
     4561 aatgccggac ttttttccgg ttcctttcag ttttcttaca gagacttgaa attacctgta
     4621 aaagcggata taattaagaa gtctactgtg gtcctataaa aaatgcgcaa aagtgtctgg
     4681 tttttaaata aaccgccggc ttatatcaca atggtataga gtcaacagct aaaagcgtaa
     4741 atactatttt tagggggaat tgtatgcaag agctagatca taaggcgatt ggccttcgta
     4801 ttcgtaaaca aagaacattt ctgaacatgt cccgtgatga attggcaaga aaaatcggta
     4861 tcacaccaac cttccttgcc gatatagaac tggggactaa gggcttttct ctaaaaagcc
     4921 tgaatcgttt ctgtgacgtt ttgaaaatgt ccgccgacgc aattctctac ggccccaaag
     4981 aatacatggg gacgaagtac gcagcactgc tggagctttt ggaacgctgt ccagcagaaa
     5041 aaggaaaata cgcagaagaa attctgactc tgtttttact cagccatgac ccagtagaat
     5101 aaaaaaatgc gggtgtccaa attgcagttg ggcacctgtt atttttttac actcttaaac
     5161 atactgccag cgcccggcgt ctcctccgct ctgctccgaa ccgcttcccg gatcagtttt
     5221 gagccgattt cccgcatttc gccagctgtg taccagggct tcgcataaag cgtataatca
     5281 atatcggtac ggtatccctg caaaatcgcc cggatctgct ccggccccat gccctgccgc
     5341 acatactccg atacgtcaag cccttcctct aaacccatcc ggatcaggta catctttttc
     5401 caatccagat ttttgtccgc atagatcgat acatctacct ttcctgtaag cccttcccgt
     5461 atttgccaca tctggcagtt tgaatactca ggatcgttat aaaaggtcac atccacaccg
     5521 gtcatcaatc cccagaaaat ttcccgtatc tgctctggtg taaaggcctc cgtaatatac
     5581 ggcgacacat cgaaaccaca ttccatcgct tcctgaatca cattctgctg ttctcttgta
     5641 taccttggct taacgcccat ttttccacaa ccccagcagc atcatcagcg cctcaaggcc
     5701 caggcattcc gcggcgacca gaccaaaccg gctgttaaag gccagtccgg caagcagcgc
     5761 gcaggcactg ataaccacca gtattctcct cgcccgtttc cggtagtggg tgcactccgc
     5821 gtcgtccagc ggttttgcgc tgttttcgac cggcgcccat ttgtagatca ccggaaaagc
     5881 ggacagcgta agcgccgcgg taaccaccgc aaccgtcccc gccgggcaga accgggcaat
     5941 gagtaaaaca gaaagtattg tgatccatga cagcagatag cagaccccgc gtgtatcggc
     6001 gtggtaaccg ccggcatagg cgcggatggc cgcataaaca attaaaaaga ctatggtctc
     6061 cggcagcatg ccgagaagca ggcccaccaa aagcatggaa gcgtagtgaa ctgccttgag
     6121 cattaaaact ctgattccaa actgatatat ttcaacatct tcatcgacca caatttctct
     6181 tctttttaat tgatagatta atgcgtcaga agctttttca aacattagaa tttacggagt
     6241 tttttaatat ttacgggagc cttttcttga tgatggatca tccaacatgc tgtgttagca
     6301 tctttgactg cttcatgatg agcgactttc gctacatttt tcaggatttt atttttgaaa
     6361 ctatcttttt tcatttagta cacctcataa cattctatat tatgtagttt atcagctgat
     6421 agatgctatt atatgtacaa agcaaccaaa tcaccatctt tattgtatca agaaataaat
     6481 ctatggtctt ttatatttta aatatgtccc aagtaagaat ttccacgctc tttttacgac
     6541 gcagatatta aaattttaac cttaaactct tcttctattt tatattgaat agttccatta
     6601 tacttttcaa ttgctgtctt tacatttttc aaaccaacac ccatatgttc tccctgtttt
     6661 gtacttttca attcattatt tttattattc actttgccat tatagctatt acaaataaca
     6721 actgttataa aatcattaaa tttgaatatt ctaaggctta tatgtcgttt atctattgga
     6781 agttcaagac atgcatcaat tgcgttatcc aataaattag aaaaaatcgt agtcacgtca
     6841 aaaaaatcca taaatccaat gtctatgtct tcaacttcta acatgacatc tatactattt
     6901 tcatcacact ttattaattt attattgatg attattgtta aaaagcgatt actacattta
     6961 aaacggcttc ccaactcatc catctttcta tatattgttc tagcataact atgagccata
     7021 tcaccattgt cattagcata aagttcttca aaagtttgca tatgattttt catatcatgt
     7081 atcaatcgtc tcgaataatc atattgtgct tcaatacttt tataataagt attttgcatc
     7141 attacctgct gttctttcaa gtccatatct ctttccaatt gatagcgttt tgatatggct
     7201 tcgaataggt ataccaaata tatatctaat ccaataaatc caaaacaaat atatgctaaa
     7261 gcaattccag atgaactttg ttgtattgtt atataaaaat aatatagcac acttatttca
     7321 aaaactgcca ataacattaa aaagatattt tgtacaattt taagtgtatt taattcattc
     7381 tttttaaata tagatacaaa aatataaaat ccacataaca aaattatttg attgcagatt
     7441 ccagaaagaa ataaaaaatt aaaactttcc tcaacacctt ctatcgtagt atccattatt
     7501 aaagaaacaa ttacgactga tataacatct gaaaagatta tataaagcgc aaagacaaaa
     7561 tcatatatta gcatccattt cttatcaaat ataaaaagtg agtaactaac taagcataat
     7621 gataacaata aaaaagttat tttaagtata ggaattccta agatattcaa tcctattgca
     7681 ataataacaa ataataaaaa gcttataaaa taattaaatt tttctttata ttttctatca
     7741 tatacttcgg acataaaacg aaacataata tatcctgtaa tcccatatga taaagccata
     7801 tccaatatat aaatccactt atccatactc ttcccctaaa cttatcctcc tagccaatcc
     7861 tctacaacag cttaaaattc tcctcaatat aatcaaacag ccgcgcctta aattccacgg
     7921 cccgtttctg ggcgatgggc agggtttcgc cattgtccag atacaggtcg gcgcccgcaa
     7981 tacgcttaca gtgaaacagg ttcacgatca cgctcttgtg gcagtattca aagtcaaagt
     8041 ccttaacctt ttccatgatc tcactcagaa cgccgctaaa ttcaaaatcg ccctgggtgg
     8101 tgctcatttt aatcttccgc cgcacacgct caaaataata aatgtcattg ctggcaaaaa
     8161 ccttcagctc gccgcccatc accagagaga tgtcatggct cttgttttcc ttttcaataa
     8221 aatcaaacac ctcggtcagc accatgttta ccttagccgt gttaaagggc ttgaccaggt
     8281 attcaaacgc gtgcacagca aaggcgttgc gcatgtagtg agtgtagctg gtgataaaga
     8341 taatcttgac ccgggcgtcc cacttgcgga tctgcttggc cgtatcaatc ccatcggttt
     8401 ccggcatctc cacgtcaaga aaaaggatat caaactggat acggtcttca agcacttcac
     8461 tgccgtcgtg atagacgtat gtctccacat caatattgtg ttcctcacca tatctgataa
     8521 tgagcgcctc cagcttttct gcaatcaaag cattgtcgtc acaaatccca attctaatca
     8581 tcccatccac tgcctttcca gtatttcttt cattatacca tattttcttc ccgcacccta
     8641 tacaaagcca tcgtgaagat tatttcccct taataatttt ataccataaa aatactctat
     8701 aaaaacgaag atttcaagat ttttttcaaa aaaagaagcc ccggcgtttg gagcttctca
     8761 aaaaagggag gggtttttca gcctcgctga ctgaaaagag gatttaatga cgcctgtctg
     8821 atggaacagg cattatgaga tttaattaaa tacgaatgat aaggtgaccg tccttaaatt
     8881 ccataaaaaa atccctctcg gattcagaga gggatgaacg aacacagtat aatctggatg
     8941 gtaagggttt ttgtttcgtt tcttaagcac tctaaatcgg agtcttttaa gaaccaatca
     9001 ctatgtcggt cttctggctc agcaatatca tctttccgcc ttcccatcat cgttgacagt
     9061 ggcttttcag aaagcatttt gcattacagc tgcgattaca gcaagggatt ctcacccttt
     9121 tcccactaca taggatcatt caatatttaa ttaacttcat catacgccct ttgagcggct
     9181 ttgtcaacaa cttcttttta aatatttacg attattaaag cctgccttct ctggccgcca
     9241 gctgccttta taataataga gcaccagtac cgcccctgtc acaatccagg tcagcggata
     9301 gctgatgtag atcatgcgcg cgtcgtggac aaaccgcagg gtggtaaaaa tccagcccag
     9361 ccgcaggccg cacatgcaca aaagcgtgat gatcataggg attaccgtgg ccccggcccc
     9421 ccgcagcacg cccacaaata cctgatccgc ggcgtaaata ccataaaggg gcaccacggt
     9481 gtaaagctgg cgcatgccgt ttaaaaccac tgtttcgtcc gaggtaaaca tgcccagaat
     9541 cagacgggcg ttcaggataa tggctgcgcc caggccgatg gttacgccca cgcacaaaag
     9601 caggcagacg tttttgccct ttaccaccct ctcccagcgc ccagcgccca tgttctgccc
     9661 tacaaagctg gaaattgcca ggcagaaggc gtcaatgggc ataaaaagaa atccgtcaat
     9721 tttcatatag gcggtaaacc cggccatgac ctccagccca aaggtattga tctgggactg
     9781 gaccactacg ttggagaagc agaccagcac agactgcagt ccggcgggca ggccaatacg
     9841 cacgatatcc ctgaacacct gtgcgtgaaa ccggattttg gccagccgga gccggtagat
     9901 gggatcagcc ctcagcagaa taatgacaat cagcacagcg gcggccatct gtgaaaacac
     9961 cgtggccagt gcagcgccgg ccacgcccat gccaaggggc cccacaaaga gcaggtcaag
    10021 gccgatgttc agcacaacgg tgaccaccag gcaggccagc ggggttttgg aatcgccaac
    10081 cgcacgcaga atcccgctgc caatgttgta caaagtcatg gggatcatgc ccagaaaata
    10141 gatgcggata tagggcacgg cgtatgcaag cccggcctcg gggatgttca tcatccgcag
    10201 catggccggc gcaaaggcca ggcccaggac agtgagcgca aggccggccg ccaggctcag
    10261 ggccacggcg gtgtgcacag cctcctgcac cttgtcgtat ttccggctgc cgaaaaactg
    10321 tgaaatcagc acgctggccc cgatggacag gccgatgaaa aaatagatca taaaggtgat
    10381 gagcaggctg ctcgcgccca cggcggccag ggcatttgcg cccacaaaac ggccgacgat
    10441 cacagcgtcc acggtgttgt acagctgctg gcagaggttt gagaacatga ggggcagggc
    10501 gaacagcagc agctgccgac caatcttccc ctcggtcatc tggcctttta acgggatttc
    10561 acgggtttct tccataatgc tttccttaac taatagagat gacaggccac ctggtggcct
    10621 ggcgccacgt ccttcaggcg tggcttttcg gctttgcaga cgggcatgcg tttctcacac
    10681 cgcccggcaa aggggcagcc cggaggcagc tccagcgggc tcggcggatc gccggggatg
    10741 gtttcgattt tcttgcagca gtccatatgc agcgagaaca ccgaccccaa aagcgcctgg
    10801 gtgtaggggt gcatggctgt ttcacacagc tctccgccgc ccacggtctc cacgatattg
    10861 cccaggtaca tgacagccag ccggtggctc aggctctgga ccagggccat gtcgtggcag
    10921 ataaagatca tggcaatgtt tttttccttc tgaagccggg tcagcagcgc cacgattttc
    10981 ttctggatgg aaacgtccag ggccgaggtg gcctcgtcgc agaccagcac ctcggggttc
    11041 agggccagcg ctctggcgat gcccacgcgc tggagctgtc cgccgctcat gctgtggggg
    11101 tagcgctgca taaaatcagc gtccagttct accatctcaa gcagttccct ggccttttcc
    11161 gaccgctgtt tccggaggag ccggccaaaa ttgacaagcg gctcggtaat aatgtcgccc
    11221 actcgcattt ttgggctgaa ggaggcagcg gggtcctgga agaccatctg gatatgctgt
    11281 cttttccgcc gggcctcctc gcccgagagc ccggcaatat cttttcctct aaagtatatc
    11341 gcaccggcag tgggcttttc aagctgcacc agcattttta caaaggtact ttttccgcag
    11401 ccgctttctc ccacaatgcc aagggtctcc ccgcgccgcg ccgccaggct gatgctgtcg
    11461 caggctgtaa ggggccggcc gtctgaggta tgaaagcgtt tggtcagccc tctggtttcc
    11521 aggatgattt catgattttc agacaaagcg cgcacctcca agctcgggca ctgctgccac
    11581 cagttctttt gtgtattcct gtctgggatg aaggatcacc tcttcccggg tgccgctctc
    11641 cacaatctcg ccggcccgca tgacaatgat ccggtctgcc atatacgcgg ccacgcccag
    11701 gttatgtgtg acgatcatga tccctgtgcc aaagttctgg cggagggcca tcatctggcg
    11761 cacaatctgg gcctgggtgg tcacatcaag agcgctggtg ggctcatcgg ccagcagcag
    11821 atcgggctca aaagccatgg ccatggcaat gcccacccgc tgccgcatgc cgccgctcag
    11881 ctgaaagggg tagctgtcca tgatgtttcc cgcgtcgggc aggcgcatgc gtgtcagcat
    11941 ctccacggcg cggtcccggg cgctgtccct tgtcacagcc ttgtgggtct ggatatagtt
    12001 cacaaattgc cggccgattt tgcgaatggg gttgagcgtg cttccgctgt cctgaaaaat
    12061 catggcgatg cggctgcccc gcaggtcccg ccagtcctcc ggcgttttct ggagcagggg
    12121 ctcctcatca aaaagaatct cgccgccggt gacccgccca tttcccggca gcaggccgag
    12181 aatggagcgg attaccgtgg tttttccgct gccgctctcc cccacaacac tgatgatctc
    12241 atgctttttc atgtgcaggt caaagtgcgc caccgccggc ggtttttcac cgtactgtac
    12301 gctcatatcc cggattttca gcatcttttt ctcctctcat tagcgcgcct gcctactgcg
    12361 ccggcttgat ttccttggtc agccagtaat aatcggctgg cagcatctcg acgccggtaa
    12421 tcttcttgct ggaaataatg ttggtttccg gataagcgta gaagacgctg gccgcgtcgt
    12481 tcatgataag ctgctgggca cggatgacca gctcacgccg tttggcggtg tcaaactcag
    12541 tggacagctg gtctaagacc gcgtcgacct cagggttgct gtagccggct gtgttggcgt
    12601 ttttgttttc atcggtatgg gttttccagt attccttcag gtagttttcc gggtcgccgg
    12661 tgttggctgt gatgacattc cagatcagca ggtcgtactc gccgttttcc tgcatgtcca
    12721 gcagggtggt atactcatag gtttcaacct tcacgtcaat gccgatctcc ttcaggttcg
    12781 cctgggtggc agtagccaga atgggcagct cggcgcggct gtcgtaaatg acatactgga
    12841 gggtcaggtt ctggccgtcc ttttccacaa tgccgtcgcc gttggtgtcc gcgtagcctg
    12901 cctcagccag cagctgttta gcgctttcca gattgtaggc gttctcgtcc ttcagggtgt
    12961 caaagccgta atccagagac ggcgggatcg gggccttccc ggcctcaaag gtgccgtgga
    13021 gcaggttatc cgcataggtc tggcggtcca gcgcacggat gaccgcctgg cgcaccttca
    13081 cgtctgccag cggcccgcgc tggttcataa aggaaagcac tgtccgcagc gacgcaatgc
    13141 tgttgatgtc aaaggactcg ctgccctcaa acaaagctaa gtcactgctg ctgatattga
    13201 ctgccatatc cacctcacca gactgcagcg ccatggcgcg ggtgttggcg tcgtcgataa
    13261 cctggatatt cacttcattg taaggcacct cgccgtccca gtaattttca ttttttacca
    13321 ccacgcattt ttccttgtca aaggacttaa ccgcgtaagg cccggtacag attggcccgt
    13381 cggtggcaaa ggtgctggtg tctacggtgg tgtccacgat caaaaacagc gggtcggcca
    13441 ggcagcccgg cagccccggc gtggggctct tggtcttgat tatgaggttt gagccctccg
    13501 cggtcatggc gtcatactgg aaaaagtccg agctggcgcg cttgctcatc tcaaaggttc
    13561 tctccagcga cgccttgacc aggtcagcgg tcagggctgt gccgtttgaa aatttgacgc
    13621 cgtcacggat tttgaaggtc caggtcaggt tgtcgctgcc cagctcccag ctctccgcca
    13681 gccagggctc tgcgcccatc tcatcgttga atttaaccaa ggtttcgcca acgccgtagc
    13741 gcatgaccac ccagctgaaa tactgctccg tgggctcaag cgtatccgca aagctcgtca
    13801 ctccaatatt cagctgctcc gaagaccccg aagcgccccc gctgccgccg cagccggata
    13861 aacccgtggc cgtcatggcc agaatcgcca ctgtcaatac taatttttta aacttactca
    13921 ttttatctcc tttcatattc atatgaaaat ttaattaaca acaacatcag actgtcaaaa
    13981 aagttaaaag gcaacggcag agttaaagta agaagctctt tcaatggaaa attgagaatg
    14041 gaaaatggag aatgaatgaa ctctttttct aacgaaaaag cgattcgtac agcggcctgc
    14101 ggccgctatt ctactcaaaa tgcgcagcat tttgttcctg taattttcca ttctcaattc
    14161 tacattctcc cttaactggc ctctttttaa cgctttgtcg cttgctgata agtttttttg
    14221 acacgttgaa tattttacgc cctctaatcc tgccgcggat ccagaatatc ccgaagcccg
    14281 tcgcccatca ggttaaacac tgaaaccaca ataaagatgg cgatgcccgg aaacagcatg
    14341 agccagggcg cggtctgcaa atactgcctc ccctcgttga gcatcaagcc ccattccggc
    14401 gtgggcggct gtgcccccag ccctagaaaa gagagcgctg ccagctcaag catcatggtg
    14461 cccacgtcca gtgccgcggt cacgatcatt gtcggaataa tgtttggcac cacataaccg
    14521 cccagaatat ggccagtcct cgcccctgtg accaccgccg cagagatata cgtgctgttt
    14581 ttgatcttga gcaccaggct ccggctgagc ctggcgtatt ttgtccagct caccacagcc
    14641 agggcaatga ccgtgttaaa caggctcggg cccagcatcc cggcaatggc aatggctaaa
    14701 accatgcccg ggaaggcgat catcatatcc gaaagccgca tgatcaccgc gtccgccgcg
    14761 ccgccgaaat aaccggcgat cataccgaga agggtcccgg ccgcaaagac aatgaccacc
    14821 agcgtcaccg tcatttccag agacgcccgt gtcccgtaga taattctgga cagctcgcag
    14881 cggcccagct ggtctgttcc gcaggggtac tcggctgacg gtgcccggag ggcgttctgc
    14941 atcacagcct cataggggtc atggggcgcg atccacggcg caaacactgc ggtcagcaca
    15001 atggccgctg ccagaatgcc gcagatggca aaaagcctgt tctgcctgaa aaaagccttc
    15061 atctacgcct tcaccacctt tcttttagcc tcgcggtgcc gctcccgcag tctggggtcc
    15121 agatagccgt aggagaaatc caccagcagg ttaatgacca tgtaaatcag agcaatccag
    15181 attacatagc cctgaaccag agggtaatcc cgagtggcaa tggcgttgac tgccatcttg
    15241 cccaggccgg gccaggaaaa aataatctcc accaccgctg tgccgccgag cagcgagccc
    15301 aacgacaggc ccagcagcgt gaccaggggc agcatggcgt ttggcagcac ctcccgccac
    15361 aggatggccg actccttaag gccccgggcc cgggcgccgg ccacgtagtc ctgccggagc
    15421 tcctccagca ccgcggtgcg cacctgcctt gtatatttgg ccgacatggc aatggccagt
    15481 gtgactgccg gcagcaccag cttcataaag cctgtgcccg aggtggcaat gggaaaccag
    15541 ttcagtttaa ggccaaacac gtacagcagc accagaccga tccagaaccc cgggaaggac
    15601 acaccggcaa aggaaagccc ccgcaccagg taatccggaa atttattctg ataaaccgct
    15661 gccagaattc caagggggat ggagatcaca agcatgagga tcagcgacgc ggccgccagc
    15721 tccagggtcg ggccaaggca gtcgagcagc accgcgctca ccggagcctt tgaagaatag
    15781 gatgttccca tatccccggt cacaaacccc ttaagccaat ttccatactg caccagaaat
    15841 ggatcattaa ggcccatctg ctcccgggtt tctgccagca gctcctcaga cggcaccgtg
    15901 ccgccctcca ccagcatcag ctccgccggg tcgccgggcg ataaataggt caggcaaaag
    15961 gtcagaaagc tgatgccaaa aagcaccagt acgatttgca gcaaacggtt aacaagctgt
    16021 ttcgtgttca a
//
