LOCUS       c00039_NZ_QRYH..       11314 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_QRYH01000044.1 Holdemanella biformis strain AF15-5 AF15-5.Scaf44,
            whole genome shotgun sequence.
ACCESSION   NZ_QRYH01000044
VERSION     NZ_QRYH01000044
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:10:45
            Original ID  :: NZ_QRYH01000044.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11314
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11314
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2513:3929](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(2514..3929)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..11314
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11314
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(3..1250)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 175.3; E-value:
                     2.7e-53)"
                     /gene_kind="transport"
                     /locus_tag="ctg39_1"
                     /transl_table=11
                     /translation="MKNVVEVKNVVKSFKDKIVLNHVSFSMKPGEIVGFVGQNGAGKST
                     LMKCMCNLINMDEGTISICEEDVVKQREKALSYVSCMIEGPGLFENMTGKENLELMATL
                     NHASKEKLHEMMEFTQIGSQLKTKAVSQYSMGMKQRTGLAVALMKEPKVLLLDEPMNGL
                     DATGIQGLREELIRLAKEKNVALLISSHQLGEIEKMADRIIGIHFGKIKEISMEEKENV
                     YVLETDRKIPDQSDLQIIEQTGNTYKLEVNSVMEVLSNLEKQGVQVKNITQIXXXXEEY
                     YSNTQNIRRCIQRVYSRGIIMMYELKKFIFNKRNVGVFGFLVFFLICFIGYNVYMDKHY
                     NESQIKIYQKAYRISENRMDEAGSEEESEFWKKVYRNASGLIHFYYNSENKTDEFIESK
                     LSWNHLMLQANNEGYII"
     PFAM_domain     complement(768..1193)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_1_0001"
                     /evalue="3.70E-31"
                     /label="ctg39_1"
                     /locus_tag="ctg39_1"
                     /protein_end="161"
                     /protein_start="19"
                     /score="108.5"
                     /tool="antismash"
                     /translation="LNHVSFSMKPGEIVGFVGQNGAGKSTLMKCMCNLINMDEGTISIC
                     EEDVVKQREKALSYVSCMIEGPGLFENMTGKENLELMATLNHASKEKLHEMMEFTQIGS
                     QLKTKAVSQYSMGMKQRTGLAVALMKEPKVLLLDEPMN"
     CDS             complement(1234..1515)
                     /locus_tag="ctg39_2"
                     /transl_table=11
                     /translation="MIDNLQIYSKVKGLIKAYYGIEENIIDNNYKVSLFLKPFEFSPIE
                     LVKLYILIKQSFNMDFIEEDFLNYNFLSIDSIVVMIKRKLDEKDEKCS"
     CDS             complement(1505..2524)
                     /locus_tag="ctg39_3"
                     /transl_table=11
                     /translation="MAIKTTLFFPFNDYSFSLIDYVKKINGDFVVASCKGTGLIGRDVA
                     YSVNMPDIGVNVLDIADVSWNQITDFVILNPGDNLALYKQIKKVYILAKENKITIHDLT
                     GYFDTKIKQKKDNESFSPRPISPIEKPIIYISGIFDSIHNSLISLNLKFYLKEAGYNSK
                     IMTYNKNLKYSNDIIFDSSFLEKPEKLYFTQYKLYEQIKRLDDDMNVDLIIVQVPGGFS
                     QLNNYVFNDFGIYFAFLNNLIRPDYLIVSLPYDFIDRDMVKEIEDVSESKYNKKIDAFV
                     VNNGYWRFGEGTTLSSQPKDTYLPFSLLDSIKEDDMYTINYSELVDSIINVLGEYDDR"
     CDS             complement(2514..3929)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_4"
                     /sec_met_domain="PF04055 (E-value: 5e-20, bitscore: 62.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.3e-13, bitscore: 38.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     2e-12, bitscore: 37.0, seeds: 13, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MFYHLFQNRDKKYIYDVNSNLVSYISDELFTDLQKQHSCNELCEK
                     EYEILLEKGFFKDYQFKQLYNPLSKRIEYLNDRNLSFFIFQVTQGCNLRCAYCPYSQSN
                     EKIRHHKNVNMTWEVAKKGLDFYFQHSVDSNFIGIGFYGGEPLLNFELVKRIVNYSNRL
                     FEGKDIHYSITTNGTLLTDEIISFMEKNNFQLLISLDGDKDSTDKNRHFAGNDLSVFDV
                     VLKKIKMIQEKHKLLFKKMTINMVLDPSLNMEVYEKLLDKYPFLENTNLYTVKIDDSYS
                     DKKNIISNDFINSYNYKIFLCLLETIDNFHFEKETKLFESQKKLLKDEFNNGTRNRVAE
                     YIEKDFITSGMCLPGMTKTFVSVNGDFYPCERVNEKLKDMIIGNVKDGYNLKNINNLMH
                     FNRKFGNRCINCFAVRECNLCPEQFGVSGIEENEESLQVCRAQRENFVQALKDRMSYNE
                     ILSLIDGGKIYGN"
     PFAM_domain     complement(3147..3674)
                     /aSDomain="Radical_SAM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04055.23"
                     /description="Radical SAM superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_4_0002"
                     /evalue="7.40E-17"
                     /label="ctg39_4"
                     /locus_tag="ctg39_4"
                     /protein_end="261"
                     /protein_start="85"
                     /score="62.3"
                     /tool="antismash"
                     /translation="QVTQGCNLRCAYCPYSQSNEKIRHHKNVNMTWEVAKKGLDFYFQH
                     SVDSNFIGIGFYGGEPLLNFELVKRIVNYSNRLFEGKDIHYSITTNGTLLTDEIISFME
                     KNNFQLLISLDGDKDSTDKNRHFAGNDLSVFDVVLKKIKMIQEKHKLLFKKMTINMVLD
                     PSLNMEVYEKLLD"
     CDS             4249..4698
                     /locus_tag="ctg39_5"
                     /transl_table=11
                     /translation="MAKPYNHRRAENEYKKWKEKDERFMKKNGMPMDKILLMRDFDRMQ
                     FNSDRRFLEKVDYDSEQQISKAVQPDLSELNEPKTVGDFLNSITSIAFAELLEEFGFEM
                     QLIIFLMYRGYCAKEVSKITGIPEWTICRRLAKLDYTYKIRKTNK"
     CDS             5262..5624
                     /locus_tag="ctg39_6"
                     /transl_table=11
                     /translation="MKVKKREIYLADLSDASGSEQGKVRPVLIIQNNRGNKHSPTTIVA
                     CLSSKIYTKHHLPTHCILPDGLGLKYKSMVMCEQIRVIDKSRLFKKIATLNKRQMAIID
                     KKIKISLDLRLHNPKK"
     PFAM_domain     5274..5594
                     /aSDomain="PemK_toxin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02452.19"
                     /description="PemK-like, MazF-like toxin of type II
                     toxin-antitoxin system"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_6_0003"
                     /evalue="8.40E-29"
                     /label="ctg39_6"
                     /locus_tag="ctg39_6"
                     /protein_end="111"
                     /protein_start="4"
                     /score="100.3"
                     /tool="antismash"
                     /translation="KREIYLADLSDASGSEQGKVRPVLIIQNNRGNKHSPTTIVACLSS
                     KIYTKHHLPTHCILPDGLGLKYKSMVMCEQIRVIDKSRLFKKIATLNKRQMAIIDKKIK
                     ISL"
     CDS             5736..5918
                     /locus_tag="ctg39_7"
                     /transl_table=11
                     /translation="MKPVLCEKKTYTVAEIAKILGVSKGAAYSLVKENTFKSIKIGKSI
                     RINKESFDKWFYSEE"
     aSDomain        5763..5900
                     /aSDomain="TIGR01764"
                     /aSTool="tigrfam"
                     /description="excise: DNA binding domain, excisionase
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg39_7_0001"
                     /evalue="3.10E-13"
                     /identifier="TIGR01764"
                     /label="ctg39_7"
                     /locus_tag="ctg39_7"
                     /protein_end="55"
                     /protein_start="9"
                     /score="47.8"
                     /tool="antismash"
                     /translation="TYTVAEIAKILGVSKGAAYSLVKENTFKSIKIGKSIRINKESFDK
                     W"
     PFAM_domain     5766..5903
                     /aSDomain="HTH_17"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12728.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_7_0004"
                     /evalue="1.40E-14"
                     /label="ctg39_7"
                     /locus_tag="ctg39_7"
                     /protein_end="56"
                     /protein_start="10"
                     /score="54.1"
                     /tool="antismash"
                     /translation="YTVAEIAKILGVSKGAAYSLVKENTFKSIKIGKSIRINKESFDKW
                     F"
     CDS             5931..7250
                     /locus_tag="ctg39_8"
                     /transl_table=11
                     /translation="MAVVITKRRKAYNVIYTIQNENGDIEKRYETFYNREQALKRKEQI
                     DGGKRNKIIVNKNTFFIDYLNQYVSVIIFNDCSISIYENKQSLINNYLSKVVGDKKVKE
                     LNAKTSKQIMHDLQLLPGVPLRNQISNDVICASAVRGCLNLLCQASDYLVDHNLMKLNY
                     FTEYRPKVSAKNQESPSWNLSYWTRLISNCTNEKLFILLHLCFDSGLSLSEVRAITWSN
                     LDHLEEGYIVSNKRIRRLNKNIVLEMDPSSIIQTYKKKGFQNTNTVVVLLKNKQEKKVY
                     LHSQVIELLMEWRDRYAQNHSGDSTIYSLKNSLPYDDRVVNKHFKELINKLELPGLTLV
                     KLMSFGRQKGRNEVLYSDVYYSSLGRPLRCKKPDIDGVRDFLNCRQVMECKEKWNQSFK
                     EKTSGLLPKEEHSDFDALVDKLKSDPSLKRELLNKLLEKR"
     CDS             7256..8614
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 123.7; E-value: 2.1e-37)"
                     /gene_kind="other"
                     /locus_tag="ctg39_9"
                     /transl_table=11
                     /translation="MATINKRNGKYCVIYYYVDTKGKKRQKWETFDSISEAKARKSIVE
                     AEKAKGSFIPPNTDTVESFLDTFIELYGYQNWSVSTLTRNRSTIKYYILPYIGKKKLQD
                     IKPIVIEKYYRDLKEQRVIRPMRSNTDGKVTSYILKSVHKLLSCAFGCAEKWELIASNP
                     FKKVTPPKHEYAKKEIWTSEMISRALEVCEDPKISLAIQLSFACSLRIGEVLGLQWKNV
                     FISDEDIEKDNAHIVVEQQLQRLSKKGIDELNVQDILYTFPSATDNESNTTVLVLRKPK
                     TQSSIRTIWLPNTLVQFLREWKEQQNEYKEFFRDEYHDYDMVLCFEDGRPVEHNIIRKG
                     LAKVSEKAGLPPVVFHSLRHSSTTYKLKLNHGDIKATQGDTGHAQADMVTDLYSHILDE
                     DRKINAQKFDESFYQNNDEDNAKRKKDSIDVDKLVASLKDNPDLLDKLLDALK"
     PFAM_domain     7433..7606
                     /aSDomain="Phage_int_SAM_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14659.8"
                     /description="Phage integrase, N-terminal SAM-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_9_0005"
                     /evalue="8.30E-12"
                     /label="ctg39_9"
                     /locus_tag="ctg39_9"
                     /protein_end="117"
                     /protein_start="59"
                     /score="45.2"
                     /tool="antismash"
                     /translation="TVESFLDTFIELYGYQNWSVSTLTRNRSTIKYYILPYIGKKKLQD
                     IKPIVIEKYYRDL"
     PFAM_domain     7802..8449
                     /aSDomain="Phage_integrase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00589.24"
                     /description="Phage integrase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_9_0006"
                     /evalue="5.70E-12"
                     /label="ctg39_9"
                     /locus_tag="ctg39_9"
                     /protein_end="398"
                     /protein_start="182"
                     /score="45.8"
                     /tool="antismash"
                     /translation="EMISRALEVCEDPKISLAIQLSFACSLRIGEVLGLQWKNVFISDE
                     DIEKDNAHIVVEQQLQRLSKKGIDELNVQDILYTFPSATDNESNTTVLVLRKPKTQSSI
                     RTIWLPNTLVQFLREWKEQQNEYKEFFRDEYHDYDMVLCFEDGRPVEHNIIRKGLAKVS
                     EKAGLPPVVFHSLRHSSTTYKLKLNHGDIKATQGDTGHAQADMVTDLYSHILD"
     CDS             complement(9046..9165)
                     /locus_tag="ctg39_10"
                     /transl_table=11
                     /translation="MKTALVGFFFGFGMNEAISLSMITVFACTISAIEKNKKE"
     CDS             complement(9197..10231)
                     /locus_tag="ctg39_11"
                     /transl_table=11
                     /translation="MNEVSNKFLNKVSLLIEEAKKNVKTAVNIAMVYTYFDIGRMIIEE
                     EQNGDNRAEYGKYIIRNLSSFLTEHYGKGYSISNLKNFRQFYLIYSNDSISQTVFSQFK
                     NYPTTVTGRKFYLSWSHYLKLMRISNIEERHFYEIEAVKNDWSLSELKRQYDSSLYERL
                     SLSKNKDEVMLLSQKGQIIEKPADAIKDPYVLEFLQLPELPVYSETELENKIIDHLQQF
                     LLELGKGYTFVGRQVRLTFDEEHFKVDLVFFNRILKCFVLIDLKIGELKHQDIGQMQMY
                     VNYYDRKVKLDDENNTIGIILCKDKKQSIVEMTLPENNNQIFASKYQTVLPSKEELQHL
                     LNEE"
     PFAM_domain     complement(9209..9673)
                     /aSDomain="YhcG_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06250.13"
                     /description="YhcG PDDEXK nuclease domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_11_0008"
                     /evalue="1.60E-57"
                     /label="ctg39_11"
                     /locus_tag="ctg39_11"
                     /protein_end="341"
                     /protein_start="186"
                     /score="193.7"
                     /tool="antismash"
                     /translation="DAIKDPYVLEFLQLPELPVYSETELENKIIDHLQQFLLELGKGYT
                     FVGRQVRLTFDEEHFKVDLVFFNRILKCFVLIDLKIGELKHQDIGQMQMYVNYYDRKVK
                     LDDENNTIGIILCKDKKQSIVEMTLPENNNQIFASKYQTVLPSKEELQHLL"
     PFAM_domain     complement(9746..10198)
                     /aSDomain="DUF1016_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF17761.3"
                     /description="DUF1016 N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_11_0007"
                     /evalue="1.50E-37"
                     /label="ctg39_11"
                     /locus_tag="ctg39_11"
                     /protein_end="162"
                     /protein_start="11"
                     /score="128.9"
                     /tool="antismash"
                     /translation="VSLLIEEAKKNVKTAVNIAMVYTYFDIGRMIIEEEQNGDNRAEYG
                     KYIIRNLSSFLTEHYGKGYSISNLKNFRQFYLIYSNDSISQTVFSQFKNYPTTVTGRKF
                     YLSWSHYLKLMRISNIEERHFYEIEAVKNDWSLSELKRQYDSSLYER"
     CDS             complement(10483..10860)
                     /locus_tag="ctg39_12"
                     /transl_table=11
                     /translation="MWLYRFWLLCDLFIPFIMIVVGRMTSKHCPKNINSLIGYRTTRSM
                     KNMDTWKFAHEYCGKLWWKIGCIMIILSALIYIPLYQSDNNVIGIAGVVLITIQCITLI
                     ASIYPTEKALKEHFNDDGTRK"
     PFAM_domain     complement(10537..10767)
                     /aSDomain="SdpI"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13630.8"
                     /description="SdpI/YfhL protein family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_12_0009"
                     /evalue="6.20E-21"
                     /label="ctg39_12"
                     /locus_tag="ctg39_12"
                     /protein_end="108"
                     /protein_start="31"
                     /score="74.3"
                     /tool="antismash"
                     /translation="NINSLIGYRTTRSMKNMDTWKFAHEYCGKLWWKIGCIMIILSALI
                     YIPLYQSDNNVIGIAGVVLITIQCITLIASIY"
ORIGIN
        1 ttgatgatat acccctcatt atttgcctgt aacatcaaat gattccagct caattttgat
       61 tctataaatt catctgtttt attttcactg ttgtagtaaa agtggatcag accactcgca
      121 ttgcgataaa cctttttcca aaattcagac tcttcttcac ttcctgcttc atccattctg
      181 ttttcagaaa ttcgataggc tttttggtag attttgattt gagattcatt atagtgttta
      241 tccatatata cgttataacc aataaaacaa ataagaaaga atacaagaaa tccaaataca
      301 ccgacatttc gtttattaaa gataaacttt ttaagttcgt acatcataat gatgcctctt
      361 gaataaactc gttgtataca tcttctaatg ttttgtgtat ttgagtaata ttcttcacnn
      421 nnnnnnnnta tttgagtaat attcttcact tgaacccctt gcttttctag atttgaaagt
      481 acttccataa cagaatttac ttctaattta taggtgtttc ctgtttgttc tatgatttgc
      541 aagtctgatt gatctggtat ttttctatcc gtttctaata catatacatt ttctttttct
      601 tccatggaaa tctctttgat tttgccaaaa tggataccta tgattcgatc tgccatcttt
      661 tcaatttcac ctaactgatg acttgaaatt agtaaagcta cattcttttc cttggccaaa
      721 cgtatcaatt cttcacgtaa gccttgaatc cctgtagcat ccaatccatt cattggttca
      781 tctagtaaca atactttagg ttctttcatt aaagccacag ctaaacctgt tctttgtttc
      841 atgcccatgg aatattggga tactgcctta gttttcagct gagaaccaat ctgagtaaac
      901 tccatcattt catgcagctt ttcttttgaa gcatgattta aagtggccat taattccaga
      961 ttttctttac ctgtcatatt ttcaaataat ccaggacctt caatcatgca tgatacatat
     1021 gataatgctt tttccctttg tttaactaca tcttcttcgc aaatagaaat agttccttcg
     1081 tccatattta tcaaattaca catacatttc attaatgtgc ttttccctgc gccattttgt
     1141 ccaacaaagc caactatttc accaggtttc atactaaaag aaacatgatt taatacaatt
     1201 ttatctttga aactcttaac tacatttttc acctcaacta catttttcat ctttctcatc
     1261 caactttctt tttatcataa caacgataga atcaatactc aaaaaattat aatttaaaaa
     1321 atcctcttca ataaagtcca tattaaatga ttgcttaatc aaaatatata actttaccaa
     1381 ctctataggg ctaaattcaa acggttttaa aaataatgat actttataat tgttatcaat
     1441 aatattttct tcaattccat aatatgcttt aataagtcct ttaactttac tatatatttg
     1501 taaattatct atcatcatat tctcctaaaa cattaataat actatctacc agttcagaat
     1561 aatttatagt atacatatcg tcttctttaa ttgaatctaa aagactaaac ggaagatatg
     1621 tatctttagg ttgactagat aaagtcgttc cttcgccgaa tcgccaataa ccattattaa
     1681 ctacaaaagc atcaattttc ttattatatt ttgactctga aacatcttca atttctttta
     1741 ccatatctct atcaataaaa tcataaggta aagacactat taaataatca ggtcgaatta
     1801 aattgttaag aaaagcaaaa taaattccaa aatcattaaa tacataatta ttgagttgcg
     1861 aaaaaccacc gggtacttga acaataatta aatcgacatt catatcgtca tccaatcttt
     1921 taatttgctc atacaattta tattgggtaa aataaagctt ttctggtttt tccaaaaaag
     1981 atgaatcaaa aataatatca ttagaatatt ttaaattttt attataagtc attatttttg
     2041 aattatatcc tgcttctttt aaataaaatt ttaaattcaa actaatcaaa ctgttatgta
     2101 tagagtcaaa tattcctgaa atataaataa ttggtttttc aattggacta attggacgag
     2161 gactaaaaga ttcattatct tttttttgct ttattttagt atcaaaataa ccagttaaat
     2221 cgtgaatagt tatcttattc tcctttgcta aaatgtatac tttttttatt tgcttataca
     2281 aagccaaatt atcaccaggg tttagaatta caaaatctgt aatttgattc caactaacat
     2341 ctgcaatatc tagcacattt actcctatat ctggcatatt aaccgaataa gcaacatctc
     2401 ttccaataag tccagtacct ttacaacttg caacaacaaa atcaccattt atctttttta
     2461 cataatcaat tagtgaaaat gaataatcat taaaagggaa aaacaatgta gttttaattg
     2521 ccatatatct ttcctccatc gattaacgaa agtatttcat tatatgacat tctatctttt
     2581 aatgcctgaa cgaaattttc tctttgtgct ctgcatactt gtaaactttc ttcattctct
     2641 tctataccac ttacaccaaa ctgttctgga cataaattac actcacgaac agcaaaacaa
     2701 tttatgcatc tgtttccaaa ttttctatta aaatgcatta aattgttaat attctttaaa
     2761 ttatatccat ctttcacatt tccaataatc atatctttta atttttcatt aactctttca
     2821 caaggataaa aatcaccatt tacagaaaca aatgtttttg tcatacctgg taaacacatt
     2881 cctgaagtaa taaaatcctt ttcaatatat tctgcaactc tatttctagt tccattatta
     2941 aattcatctt ttaataactt tttttgtgac tcaaataatt tggtttcttt ttcaaaatga
     3001 aaattatcaa ttgtttctaa caagcacaga aatatcttgt aattgtatga atttataaaa
     3061 tcattactta ttatattttt cttgtccgaa taagaatcat cgatttttac agtatataga
     3121 tttgtattct ctaaaaaagg atatttatcc aataattttt catagacttc catgtttaaa
     3181 gatggatcca acaccatatt tattgtcatt tttttgaaca gtaatttatg tttttcttga
     3241 atcattttaa tctttttcaa aactacatca aaaacactca aatcattccc tgcaaaatgt
     3301 ctatttttat ccgtggaatc tttatcacca tctaaactta ttaataattg aaaattgttt
     3361 ttttccataa aagaaataat ttcatctgtt aacaaagtgc catttgttgt tattgagtaa
     3421 tgaatatctt taccctcaaa taatctattt gaataattta caatacgctt taccaattca
     3481 aaattaagta atggttctcc tccatagaaa ccaattccaa taaaattaga atctactgaa
     3541 tgttgaaaat aaaaatccaa accttttttt gcaacttccc aagtcatatt tacattctta
     3601 tgatgcctta tcttttcgtt agattgagaa taaggacagt atgcacaacg caaattacaa
     3661 ccttgagtca cttgaaaaat aaagaaagat aaatttctat cattcaaata ttcgattcgc
     3721 tttgaaagag gattgtagag ttgtttaaat tgataatctt taaaaaatcc tttttctaat
     3781 aatatttcgt attctttttc acatagctca ttacacgaat gttgtttttg caaatctgtg
     3841 aacagttcat ccgatatata agaaaccaaa ttactattaa catcgtaaat atacttttta
     3901 tctctgttct gaaataaatg atagaacata tgtaagcacc tccttatttt ctgaaacctc
     3961 ttacatatta tatatcattt acttattcat ttttcaatat ttttttatta atataatatt
     4021 tttattctct acccgaatta tttataaatt ataatttatt ggtacagatc tctgtttcag
     4081 acagtggatc tgtttttttt atattatttg gcaaattaga agaagggata ctcttctaat
     4141 caaatttttt aaaaaatttc ttcgattgtg caattttttg tagttttcgt cggctcgatt
     4201 atgaggggat atcccttcga agcttagcta tgaaaaggag gaataataat ggctaaacct
     4261 tataatcacc gtcgtgcgga aaatgagtac aagaaatgga aggagaaaga tgaacgattc
     4321 atgaaaaaga acggaatgcc catggataaa attcttttaa tgagagattt tgatagaatg
     4381 caatttaact ccgatcgaag atttttggaa aaagtagatt atgatagtga acaacaaata
     4441 tcaaaagctg ttcagccaga tttatctgaa ttaaacgaac caaaaactgt tggagatttc
     4501 ttgaattcca taacaagtat agcttttgca gaattattag aagaatttgg ctttgagatg
     4561 cagctgatta tttttttaat gtatcgtgga tattgtgcaa aagaagtatc taaaatcaca
     4621 gggattcctg aatggacaat ttgtagaaga ctagcaaaac tagattatac ctataaaata
     4681 aggaaaacaa ataaataatt gaattgcgga atcgaaagcg attccgcatt cttttttata
     4741 ctcagattta ttggttttag ctactgtaag cattaaattc ttgatttatt cattgaaaac
     4801 tcatgttgaa actatccgtt ttagaaaaaa atacactttt ttttataaaa ctgcaatttt
     4861 gacctgtttt cgtcggctca ctagtgaagg gggatataca tatcttccta gtagctcttt
     4921 gaaaactcaa taacaactat tagatacaaa acttatatat tcgagctgga tcactactgc
     4981 gcgatgatga agcaattcga gcgatgatac tttagaatga tcaacaattt tgctgattgt
     5041 gccatgacaa tatataagat aatgatactt ctagcgacag gcccaagcgt aatatgggtt
     5101 ggtgagattc caatgaaaga taattagcaa ctatcttgtc taataggatt cctttgtttt
     5161 cgggtaatca ggtgataaat agaagacgcg atgaatattt taatattaat tatcaaccag
     5221 gagatgtcct ggttttacat atattatagg agtggataga aatgaaagta aaaaaaagag
     5281 aaatctattt agcagatctg agtgatgcct caggatcaga acaaggaaaa gttagaccgg
     5341 tattaattat tcaaaataat cgtggaaata aacatagtcc aactacgatt gttgcgtgtc
     5401 tttcttctaa gatttataca aaacatcatc ttccaacaca ttgtattttg ccggatggac
     5461 taggattgaa gtacaaatct atggtgatgt gtgaacaaat tcgagtgatt gataaatcaa
     5521 gattatttaa aaagatagca acattaaata aaagacaaat ggctattatt gataagaaaa
     5581 taaaaattag tttagattta cgtttacata acccgaagaa atgattcttc tggttatgga
     5641 ctctttccct ttggaagcag taatgaaaca ctgcttcctt tgtttgtagc tgggaattgt
     5701 gttttttgaa agtttatagt gaggaggaaa aggaaatgaa acctgtgtta tgtgaaaaga
     5761 aaacttacac agtagctgaa atcgcaaaga tattaggtgt aagtaaagga gctgcttatt
     5821 cattagtgaa agaaaatact tttaaaagta taaagattgg taaatctatt cgcataaaca
     5881 aggaatcctt tgacaaatgg ttttatagcg aagaataggg aggactaaaa atggccgtag
     5941 tgattacaaa aagacgtaag gcatacaatg taatttatac aatccaaaat gagaatgggg
     6001 atatagagaa aagatatgaa acgttctaca atcgagagca ggcattgaaa cgtaaagaac
     6061 aaatagatgg tggaaaaaga aataagatta ttgtaaataa gaatacattc tttattgatt
     6121 atttgaatca atacgtaagt gtgattatat ttaatgattg ttcgatttca atatatgaga
     6181 ataaacaatc tttgatcaac aattatttaa gtaaagttgt aggagataaa aaggttaaag
     6241 agcttaatgc taaaacatca aaacaaatta tgcatgatct tcagttattg ccaggtgtac
     6301 ctcttagaaa tcaaatatca aatgatgtta tttgtgcatc tgctgtaaga ggctgcttaa
     6361 atttattatg ccaggccagt gactatttgg ttgatcataa tttaatgaaa ttaaattatt
     6421 ttacagaata taggccaaaa gtaagtgcca agaatcaaga gtcaccaagt tggaacttgt
     6481 cttattggac tagattgatt tctaattgta caaatgaaaa gttgtttatt ttattgcatt
     6541 tatgttttga ttcaggtctt tctttaagtg aagtgagagc tattacctgg agtaatttgg
     6601 atcatttaga agaagggtat atcgtatcga ataaaagaat tagacgattg aataagaata
     6661 ttgttttgga aatggatcca tcttcaatta ttcaaactta taagaagaaa ggatttcaaa
     6721 atacaaatac agttgtagta cttctaaaga ataaacaaga aaagaaagtg tatttacata
     6781 gccaggtcat tgaattgttg atggaatggc gggatagata tgcacaaaat catagtggtg
     6841 attctactat ttacagtttg aagaatagtc ttccttatga tgacagagtt gtaaacaaac
     6901 acttcaaaga acttattaat aaattagaat taccaggatt gacattggta aaactgatgt
     6961 catttggtag acaaaagggt agaaatgagg ttttgtatag tgatgtgtat tattcaagtt
     7021 tggggcgacc tttaagatgt aaaaagcctg atattgatgg ggttcgtgat tttttaaatt
     7081 gcagacaggt gatggagtgt aaagaaaaat ggaatcaatc ttttaaagag aaaacatccg
     7141 gtttactccc aaaagaagaa cattctgatt ttgatgcatt ggtggataaa ttaaaatcag
     7201 atccatcttt aaaaagagag ttattaaaca aactattaga aaagagatga tatgaatggc
     7261 aacaattaat aagcgtaatg gtaaatattg tgtaatttat tattatgtag acacaaaagg
     7321 aaaaaagaga caaaaatggg aaacatttga ttcaatttct gaagctaaag ctagaaagtc
     7381 aatagttgaa gctgaaaagg ctaaggggtc ttttatcccg cctaatacag atactgttga
     7441 atcattttta gatacattta ttgaacttta tggctatcaa aactggagtg tttctacatt
     7501 aacaagaaat cgttctacaa ttaaatatta tattcttcca tatataggta aaaagaagct
     7561 gcaagatatt aagccaattg tgattgaaaa atattatagg gatttaaaag aacaaagagt
     7621 tattcgacct atgagatcaa acacagatgg gaaagtaact tcttatatat taaaatcggt
     7681 tcataagtta ttgagctgtg cctttgggtg tgctgaaaag tgggaattaa ttgcgtccaa
     7741 tccttttaaa aaagttacac ctccaaaaca tgaatatgcc aaaaaagaaa tttggacttc
     7801 agaaatgatt tctagagcac tagaagtttg tgaagatcca aagatttcat tggcaattca
     7861 actatcgttt gcgtgttcat tacgtattgg tgaagtttta ggattacaat ggaaaaatgt
     7921 attcataagc gatgaagata ttgaaaaaga taatgctcat attgttgtag aacagcaatt
     7981 acaaagatta tctaaaaagg gaattgatga actgaatgtt caagatattt tgtatacatt
     8041 tccatcagct actgataatg aaagcaatac aacagtattg gtgttacgaa aacctaaaac
     8101 acaatcaagt attcgtacta tatggctacc taatacattg gtacaatttt tacgtgaatg
     8161 gaaagaacaa caaaatgaat acaaagaatt ctttcgagat gaatatcatg attatgatat
     8221 ggttttatgt tttgaagatg gtagaccagt agagcataat atcattcgta aaggattagc
     8281 taaggtttca gaaaaggctg gacttccacc ggtggtattt cattcgcttc gtcattcaag
     8341 tacaacatat aaattaaaat taaatcatgg tgatataaaa gcaacacaag gagataccgg
     8401 tcatgctcag gcagatatgg tcacagattt gtatagtcat attttagatg aagatcgtaa
     8461 aataaatgct caaaagtttg atgagtcttt ttatcagaac aatgatgaag acaatgccaa
     8521 aaggaagaaa gatagtattg atgtggataa gctggttgct tctttaaaag acaatccaga
     8581 tctactggat aaactattag atgcattaaa ataagatgtc cctatcaagg gactttttta
     8641 ataaaatggc ttctagctaa tagccagcta atattgacta tataaaaaaa acgaaatcag
     8701 gtgaaaaatt ccgtatattt tattgagcgg tcaaaattag aaaacacaaa aaagccgata
     8761 aataaagcat atagcgaaat tatatgtaaa tttcaagatt aaataaaatt gtgatgagtg
     8821 gtctcctaag cgaaaggtcg taggttcgac tcctatctgg gacgccaatt ttaagggatt
     8881 taacagggtt ttaatgaatt ttggcctgtg aatgataaaa gagatttgtc tgatgtgtat
     8941 tcatcattca aatctctttt tgttttgtga taagtgagga gtgggaaatg ttttcgttcc
     9001 aagttaattt ctttgtgtga attcttgtag ataaattaga atttgtcatt ccttcttgtt
     9061 cttttcaata gcactaatcg tgcaagcaaa aacagtaatc attgaaagtg atattgcttc
     9121 gttcattcca aagccaaaga aaaagccgac taatgctgtt ttcataatat acttccatca
     9181 agtccgattt gtaattctat tcttcattta aaagatgttg taattcttct ttgcttggta
     9241 atactgtttg gtatttactc gcaaatattt gattattgtt ttcaggtaaa gtcatttcca
     9301 caatagattg ttttttatct ttgcatagaa taattccaat tgtattattt tcatcgtcaa
     9361 gttttacttt acgatcatag taattcacat acatttgcat ttgtccaatg tcttgatgtt
     9421 ttaattctcc aatttttaaa tcaattaata caaaacattt taatattctg ttgaagaata
     9481 ctaaatcgac tttgaaatgt tcttcgtcaa atgttagtct aacttgtcta cctacaaatg
     9541 tatagccttt accaagttcg agtaagaatt gttgtaaatg atcaataatc ttattctcta
     9601 actcagtttc ggaatataca ggtaattctg gcaattgtaa aaactctaat acatatggat
     9661 ctttaattgc atctgctggc ttttcgatta tttgtccttt ttgtgataat aacatcactt
     9721 catctttatt tttacttaaa gatagacgtt catataatga agaatcatat tgtcttttta
     9781 attctgataa actccaatca ttttttactg cttcaatttc ataaaaatgt ctttcttcaa
     9841 tattggaaat tctcattagt ttcaaataat gtgaccagct taaataaaat ttacgtcctg
     9901 taacagttgt agggtagttt ttgaattggc taaacactgt ttggctaatt gaatcatttg
     9961 agtatataag atagaattga cgaaaatttt ttaaattcga tatggaatat cctttaccat
    10021 aatgttcagt caaaaaagat gataagtttc taattatata tttaccatat tctgctcgat
    10081 tatcgccatt ttgttcttct tcaataatca ttcgtccaat atcaaaatat gtatagacca
    10141 tagcaatatt cacagcagtt ttaacatttt tcttggcttc ttcgattaat aaagaaactt
    10201 tatttagaaa tttgttgctt acttcattca tatgtaatac accacgcttt cgctatatat
    10261 tttcattata attgcattta ccatttatat ctatagtaca atgtatataa tgtttttctt
    10321 gcgaatcctt ttctgatgag actacagaca agagaggagc agtacctaca gaataggtct
    10381 cctaagcgaa aggtcgtagg ttcgacttct atttggaatg ccaattcaaa caaaaagaga
    10441 taatttcacg tgcaatttca tttctttttt ttaagttgat atttattttc gtgttccatc
    10501 atcgttaaaa tgttctttta aggctttctc tgtcggataa attgatgcga ttaaagtgat
    10561 acactgaatt gttattagaa caacgcctgc aattccaatc acgttattat cgctttggta
    10621 taatggaata tatatcaaag cagatagtat tatcattata catcctattt tccaccaaag
    10681 ttttccgcaa tattcatgag cgaatttcca tgtatccata tttttcattg aacgagttgt
    10741 tcgatatcca atcaaactat ttatattttt tggacaatgt tttgacgtca ttcttcctac
    10801 gacaatcatt ataaacggaa taaataagtc acataataac caaaatctgt aaagccacat
    10861 aaaatttacc cacctaattt ttttatattt ttgtgtacat tataagcttt aaaaaaaatt
    10921 gtaaatattt taaacaatca gatgaaagtt atttgaaatt aaattggttt taggactggt
    10981 atatctttat agctgtcact ttcaaaaaat gaataatatt aaacttttga aagtgaatca
    11041 ttaaataaaa atagatttaa atcagtgtca aagaatactt ttattagaat aaaagaaatt
    11101 aaattgtatt tcatagaggc aactatgtga gattttctat aaccgcttac atttgataat
    11161 aaatatgtac tttttgtgcg ttgtcacgta tactaaaaag taggtgaata catattgagg
    11221 agagaataat atgataataa ggaagcgaat cttgtcaatg tcattaagtt aagaaatggc
    11281 atctttgagg ggaacacaaa aaatgtgctc ccct
//
