LOCUS       c00034_NZ_QRYH..       10279 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_QRYH01000004.1 Holdemanella biformis strain AF15-5 AF15-5.Scaf4,
            whole genome shotgun sequence.
ACCESSION   NZ_QRYH01000004
VERSION     NZ_QRYH01000004
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:10:45
            Original ID  :: NZ_QRYH01000004.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 45285
            Orig. end    :: 55564
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10279
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[50285:50564](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5279)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10279
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10279
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(901..1104)
                     /locus_tag="ctg34_53"
                     /transl_table=11
                     /translation="MTETVFMTAQEVADCLGTSKAFAYKVIQKLNREMEKEGYLTISGK
                     INRVYFNERLYGGNMVHGSLQG"
     CDS             1290..1733
                     /locus_tag="ctg34_54"
                     /transl_table=11
                     /translation="MDIGERIRFVRQFRGLTQTELAEKSGLSADENGRIRISQYENGTR
                     VPRKDMLEKISKALHINSMYLNMDDHTEALDFVFTLLDWDRTTDFIIKKETIDNENHYL
                     IDLNTNLFDDFLEAWIQKKADLKNGKISNDEYIEWTINYPTEK"
     PFAM_domain     1317..1475
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg34_54_0001"
                     /evalue="9.80E-10"
                     /label="ctg34_54"
                     /locus_tag="ctg34_54"
                     /protein_end="62"
                     /protein_start="9"
                     /score="38.4"
                     /tool="antismash"
                     /translation="VRQFRGLTQTELAEKSGLSADENGRIRISQYENGTRVPRKDMLEK
                     ISKALHIN"
     CDS             complement(2005..2640)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 195; E-value:
                     2.5e-59)"
                     /gene_kind="transport"
                     /locus_tag="ctg34_55"
                     /transl_table=11
                     /translation="MFAIQLKNIDKSFGKKKVLNNLSLQIRENEMVALIGPSGCGKTTL
                     LNILGLIEPYDSGEYLLFGKQAPQCNSNQANQTIRRYISYLFQNFALVDNFTVEQNLMI
                     ALKYTRKTKQEKHVLINEALNKVGLSEYNELKIFEISGGEQQRVALARAMIKPSKIILA
                     DEPTGALDSKNRDEVLQLLREINKQRKTIVIVTHDMTVANSCDRIIQL"
     aSDomain        complement(2008..2625)
                     /aSDomain="TIGR03608"
                     /aSTool="tigrfam"
                     /description="L_ocin_972_ABC: putative bacteriocin export
                     ABC transporter, lactococcin 972 group"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg34_55_0001"
                     /evalue="5.30E-85"
                     /identifier="TIGR03608"
                     /label="ctg34_55"
                     /locus_tag="ctg34_55"
                     /protein_end="211"
                     /protein_start="5"
                     /score="282.0"
                     /tool="antismash"
                     /translation="LKNIDKSFGKKKVLNNLSLQIRENEMVALIGPSGCGKTTLLNILG
                     LIEPYDSGEYLLFGKQAPQCNSNQANQTIRRYISYLFQNFALVDNFTVEQNLMIALKYT
                     RKTKQEKHVLINEALNKVGLSEYNELKIFEISGGEQQRVALARAMIKPSKIILADEPTG
                     ALDSKNRDEVLQLLREINKQRKTIVIVTHDMTVANSCDRIIQL"
     PFAM_domain     complement(2140..2586)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg34_55_0002"
                     /evalue="5.50E-31"
                     /label="ctg34_55"
                     /locus_tag="ctg34_55"
                     /protein_end="167"
                     /protein_start="18"
                     /score="108.0"
                     /tool="antismash"
                     /translation="LNNLSLQIRENEMVALIGPSGCGKTTLLNILGLIEPYDSGEYLLF
                     GKQAPQCNSNQANQTIRRYISYLFQNFALVDNFTVEQNLMIALKYTRKTKQEKHVLINE
                     ALNKVGLSEYNELKIFEISGGEQQRVALARAMIKPSKIILADEPT"
     CDS             complement(2642..4795)
                     /locus_tag="ctg34_56"
                     /transl_table=11
                     /translation="MKKSMAILLSIVSILTSVAFGFYMKTQDIEFFNTIEMKSNAYKIY
                     VKNSSVAYDEFLQELKSIHSQYGATIIKTDRIYEDGKEIIYKSGVYTKDFFEGLPVKLE
                     SGRLPTTSNEWLASIDTKQENQVGTISDLFNDTPLVIMPLSDFYNSKSTDINGEYTIIS
                     SNKNKEDILNALSLFLNESKNELVSADYRVAFGEGTIYFLTIILSAILLIIFCLMCVFY
                     PISRLKEISVYKLNGYKAFDIWKKLNKDVLIAPIIIFIASIPIQKIAFPTMDLFYFIKL
                     SCVQLILFVGAIGLSFLTLITVKRYSISNMLKNFFDFRISLYISYIIKFAIFVGLVFTI
                     PQLSSEVSRMIKEMQVKEAYQAQEDYVTLASFQLTGDGMQSFMNGTSQFNENLTNMFMD
                     LTKSAKAGFVQSFWYHTEGLGLFSSEIKMPNDVDTDTEFGYMLLNDNYYDRLQFDSSVS
                     KEELFDQDSLVIFAPESMKQKEATLKYFGQTQIYSADSNIKMSADDVCVKYYKDNRKQI
                     FSESLQLANEDHAFFTNPVFVCLNDKYLKVFSGYLTTQAISNPVRIYDSNENKRAINEG
                     IKKYGLELNNLQFKNVLMSGYKEQIQISQSSSIVWVAILLLVICISILSSYYILLTILI
                     SRKKEIFVKKILGYSLFNRYKNEFIYFIMIYIFGLVQIMILSRSFTSMAIYVLLVLLDI
                     LIIFRMIYVKETKQLSTMLKGEE"
     CDS             complement(5001..5279)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_57"
                     /sec_met_domain="Lactococcin_972 (E-value: 3.3e-17,
                     bitscore: 56.2, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKLVCTIMILFTCFSGSVVLATTVYPAVGGQWNYGVGITGSYSD
                     YMHGQKIHTATVSHPEATPSMARAPANSWAKARLTKYSSCSFYYGVE"
     aSDomain        complement(5007..5279)
                     /aSDomain="TIGR01653"
                     /aSTool="tigrfam"
                     /description="lactococcin_972: bacteriocin, lactococcin 972
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg34_57_0002"
                     /evalue="1.60E-14"
                     /identifier="TIGR01653"
                     /label="ctg34_57"
                     /locus_tag="ctg34_57"
                     /protein_end="91"
                     /protein_start="0"
                     /score="52.0"
                     /tool="antismash"
                     /translation="MRKLVCTIMILFTCFSGSVVLATTVYPAVGGQWNYGVGITGSYSD
                     YMHGQKIHTATVSHPEATPSMARAPANSWAKARLTKYSSCSFYYGV"
     PFAM_domain     complement(5037..5192)
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg34_57_0003"
                     /evalue="6.60E-13"
                     /label="ctg34_57"
                     /locus_tag="ctg34_57"
                     /protein_end="81"
                     /protein_start="29"
                     /score="49.1"
                     /tool="antismash"
                     /translation="GGQWNYGVGITGSYSDYMHGQKIHTATVSHPEATPSMARAPANSW
                     AKARLTK"
     CDS             5624..5995
                     /locus_tag="ctg34_58"
                     /transl_table=11
                     /translation="MNYTQLTKRESQIMTILWNHDQEMSANDIKLASDGLSIYTISQAL
                     QYLLSIGYVEVTGIGKNKKSIARLYSPCISESDYVSSFIKKETFEEIAVHYVQSSNDID
                     EITKLEHLIEKKKKELTGK"
     PFAM_domain     5639..5965
                     /aSDomain="Penicillinase_R"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03965.18"
                     /description="Penicillinase repressor"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg34_58_0004"
                     /evalue="5.60E-07"
                     /label="ctg34_58"
                     /locus_tag="ctg34_58"
                     /protein_end="114"
                     /protein_start="5"
                     /score="30.0"
                     /tool="antismash"
                     /translation="LTKRESQIMTILWNHDQEMSANDIKLASDGLSIYTISQALQYLLS
                     IGYVEVTGIGKNKKSIARLYSPCISESDYVSSFIKKETFEEIAVHYVQSSNDIDEITKL
                     EHLIE"
     CDS             5997..7103
                     /locus_tag="ctg34_59"
                     /transl_table=11
                     /translation="MNFSISSLFITLCVSLVLIALFNFILTHEKGYRLFRADLLFVLVV
                     ITCFRLFLPFELPFTKTIALPSIMNPIMSFLNYEIFHQLKVSHILIVIWLIGVLIGVGR
                     YVQNIILAKKLEAKIIQNSHCFKVSEFLDCFIYPDYDVYVTKYVPSPMVFGFKKCILIP
                     EISFTEHELSNILNHEMQHLKQHDILFKQVTSILTILYWWFPPIYWLQKCINFYIEVRA
                     DEKVTESLNPIDALDYAETLINVQKKIQFADSIISNDISAYLIGESNSILSYRVNYLLN
                     KQIKQKTNKFLLFFLFLLPILTNSIIFEAYYENPKNLNDTLSEQDLLNKNYLIQHKDGT
                     YSLCNGKESFFIDNPKSLIESGIKVVKE"
     PFAM_domain     6225..6749
                     /aSDomain="Peptidase_M56"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05569.13"
                     /description="BlaR1 peptidase M56"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg34_59_0005"
                     /evalue="1.00E-21"
                     /label="ctg34_59"
                     /locus_tag="ctg34_59"
                     /protein_end="251"
                     /protein_start="76"
                     /score="77.5"
                     /tool="antismash"
                     /translation="NYEIFHQLKVSHILIVIWLIGVLIGVGRYVQNIILAKKLEAKIIQ
                     NSHCFKVSEFLDCFIYPDYDVYVTKYVPSPMVFGFKKCILIPEISFTEHELSNILNHEM
                     QHLKQHDILFKQVTSILTILYWWFPPIYWLQKCINFYIEVRADEKVTESLNPIDALDYA
                     ETLINVQKKIQF"
     CDS             7108..7329
                     /locus_tag="ctg34_60"
                     /transl_table=11
                     /translation="MKKTINSILLLTLILSCNFIQTISVFANEIGPNPAIEARADIIEW
                     RYKLENGRVYKRRYNYTKQKWIGDWIPA"
     CDS             7966..8934
                     /locus_tag="ctg34_61"
                     /transl_table=11
                     /translation="MNNEIIKFVNGDLELDVNISPNKNTVWLTVDQLCTLFNKNKSTIS
                     RHIKNIFNEGELDEFSSVAKNATQLKRYDPRTGKDRISNVEVNYYNLDVIISVGYRVKS
                     QNGVIFRKWATSILHDYMLKGYAVNQKRLDVLNKTIAIQSRMLASTLNIEEKEVLSVVE
                     AYSNALTLLDDYDHGTIPKPDGIASIYHLTYKECRELIDSMKYGNFSDVFGVEKEEGKL
                     NGILAAIYQNVFGTELYPSIEEKAANLLYFLIKDHPFVDGCKRIGASIFLEFLNKNKHL
                     IIDGKQIISDSALVAITLMIAESRPEEKETMVKLVMNFLNA"
     PFAM_domain     8203..8376
                     /aSDomain="Virulence_RhuM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13310.8"
                     /description="Virulence protein RhuM family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg34_61_0006"
                     /evalue="3.10E-20"
                     /label="ctg34_61"
                     /locus_tag="ctg34_61"
                     /protein_end="137"
                     /protein_start="79"
                     /score="72.6"
                     /tool="antismash"
                     /translation="DRISNVEVNYYNLDVIISVGYRVKSQNGVIFRKWATSILHDYMLK
                     GYAVNQKRLDVLN"
     PFAM_domain     8584..8790
                     /aSDomain="Fic"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02661.20"
                     /description="Fic/DOC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg34_61_0007"
                     /evalue="1.80E-06"
                     /label="ctg34_61"
                     /locus_tag="ctg34_61"
                     /protein_end="275"
                     /protein_start="206"
                     /score="28.8"
                     /tool="antismash"
                     /translation="GNFSDVFGVEKEEGKLNGILAAIYQNVFGTELYPSIEEKAANLLY
                     FLIKDHPFVDGCKRIGASIFLEFL"
     CDS             9139..9957
                     /gene_functions="other (smcogs) SMCOG1157:hypothetical
                     protein (Score: 255.9; E-value: 6.9e-78)"
                     /gene_kind="other"
                     /locus_tag="ctg34_62"
                     /transl_table=11
                     /translation="MHKCKVIAVTNQKGGVGKTTTTANVAIGLERYGYKVLIVDFDPQG
                     DLTTSLGWKSNDALECSVSNLLDAYINDKEMDYSSLILKHKEDVDVIPANIELADMDIR
                     LVSVINREQTLSSCIEPLRDDYDFILIDCPPSLGMLTINALSAADEVLIPVQAQFLPAK
                     GMTQLLQTVNKVQRKINTNLKVAGIVMTLVDMNTTVAKSTIETIQESFGKNIRVFDTII
                     PKATKASEATIAGVSIYAYAKDSKVAKAYDNLTKEIITDQKVKHKDRDCR"
     PFAM_domain     9148..9693
                     /aSDomain="AAA_31"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13614.8"
                     /description="AAA domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg34_62_0008"
                     /evalue="2.10E-59"
                     /label="ctg34_62"
                     /locus_tag="ctg34_62"
                     /protein_end="185"
                     /protein_start="3"
                     /score="200.4"
                     /tool="antismash"
                     /translation="CKVIAVTNQKGGVGKTTTTANVAIGLERYGYKVLIVDFDPQGDLT
                     TSLGWKSNDALECSVSNLLDAYINDKEMDYSSLILKHKEDVDVIPANIELADMDIRLVS
                     VINREQTLSSCIEPLRDDYDFILIDCPPSLGMLTINALSAADEVLIPVQAQFLPAKGMT
                     QLLQTVNKVQRKINTNLKV"
     CDS             9967..10269
                     /locus_tag="ctg34_63"
                     /transl_table=11
                     /translation="MKNNSVHLIGTLTRDIELSKNSKGNSFVRFTLACTRDNKPFTDFI
                     NCIAFGEVANALCKHSDKDTAYEINGYLRISSYEKDGKKTYSTIVVVESFTLLND"
     PFAM_domain     9976..10257
                     /aSDomain="SSB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00436.27"
                     /description="Single-strand binding protein family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg34_63_0009"
                     /evalue="1.30E-15"
                     /label="ctg34_63"
                     /locus_tag="ctg34_63"
                     /protein_end="97"
                     /protein_start="3"
                     /score="57.4"
                     /tool="antismash"
                     /translation="NSVHLIGTLTRDIELSKNSKGNSFVRFTLACTRDNKPFTDFINCI
                     AFGEVANALCKHSDKDTAYEINGYLRISSYEKDGKKTYSTIVVVESFTL"
ORIGIN
        1 tgagaatgtc ttaaatcatg aattcgaatc actttaaccc cactgagttt gcaccctctc
       61 aacatttcat gatgcaaata agacttgcta accggaaata acaggtcatc ttcatttact
      121 ttatacaaat gatccatata gttttttaat tcatcacaca aaaaatcagg taaatctatt
      181 gtgcgaatac tcgtctctgt tttaggatcc gtaatcactg tttctccttc tattatttga
      241 agggatttat caatttggat cgtttgattc actaaatcaa tatccttctt tgtcaaagca
      301 cgcagttcac ctaagcgaag tccacaccag aacaaaacct caaaacaaat gtagcttaac
      361 gttttatctg atactgcatc aacaaactta cgatattcat caagcgtcca aaattgttgt
      421 tcctttttcg tttttacctt gaaacaccct gtctgtgctg ctgcatttgt tcttaaacca
      481 taatacttgc aagcatgatt taatatagcg ctcaactgtg catgcatctt aatcagagta
      541 tcccctgcat atgatttacc attctttttt ttgccatcca acatctgatt ctgccacctc
      601 atgacttcct taggtgtaat atcacacaat cgaagttcat caaagtaagg acgtattttg
      661 atttcaataa tgtttttctt agtgatcatt gtattcttac gcactcgctt ttccagatct
      721 tcatagtaaa tagggatgaa atccttaaaa agcatttttt gattgtccga tattctcgat
      781 acaaaagaca attcatattc aagagcttct ctttttgtct gaaatccccg cttaaacaat
      841 ctcttttttg aaccatccca atctgtataa cgctttgaaa cataccaggt gctcttattc
      901 ttatccttgt aaactgccat gtaccatatt ccctccatac aatcgctcat taaaataaac
      961 acgattaatt tttccggaaa ttgtcagata cccctctttt tccatctctc gatttagttt
     1021 ttgaataacc ttataagcaa atgcttttga agtacccaaa caatccgcta cctcctgtgc
     1081 cgtcataaat actgtttctg tcattttttt gttcctcctt tttatataat gtaaactatt
     1141 atgtttacta catatacagt atagtaaaca tttatgatta cgtcaattag attatgtaac
     1201 tttttttgtt tactgtaaac tcgtttattt tctatccatt ttatctatgt tataattctt
     1261 aatagatata agacggaggt aacataaaaa tggacattgg ggaaagaata agatttgtcc
     1321 gtcaatttcg aggtttaaca caaaccgaac tagccgaaaa atccgggctt tcagcagatg
     1381 aaaatggaag aattcgtatt tcacaatatg agaacggaac tagagttcca cgtaaagaca
     1441 tgttagaaaa aataagtaag gcgctacata tcaattctat gtatttaaat atggacgatc
     1501 ataccgaagc acttgatttt gtttttacat tactcgactg ggacagaaca actgatttca
     1561 ttataaaaaa agaaacaata gataatgaaa accattattt aattgatttg aacacaaatc
     1621 tttttgatga ttttttagaa gcatggatac aaaaaaaagc cgatctaaaa aacggtaaga
     1681 tcagcaacga tgaatacatt gaatggacaa ttaattatcc aactgaaaaa tagccttgat
     1741 aaaaagtgtc ttatataagg cacttttatt catgttgtct ctttttaaat ttgattcttt
     1801 atatttctaa atcatttatg tatattatgc actcatttta gagccactgt gagtacactc
     1861 ttttggattt ctagaacttt tataaacaga ataatcaaaa aaggtatcca agactccgtt
     1921 gtttaaagac ggagagggat accgatttga atatatacac aagcagtata cttgtgtcaa
     1981 ttcctactat gacaatatat agacctatag ctgtataatt ctatcacatg aatttgcaac
     2041 ggtcatatcg tgagttacaa tgactatcgt ttttctttgc ttattgattt cacgtaaaag
     2101 ttgtaacact tcatctctat tcttagaatc taatgcacct gtgggctcat cagctaaaat
     2161 aattttactt ggctttatca tagctcttgc caaagccaca cgctgttgtt ctccacctga
     2221 aatctcaaat atttttaact cattatactc acttaagcca actttattca atgcttcatt
     2281 aatcaaaaca tgcttttctt gttttgtttt tctagtatat tttaatgcta tcattaaatt
     2341 ttgctccaca gtaaaattat cgacaagagc aaagttttga aaaagataag agatatatct
     2401 acgaattgtt tggttagctt gattggaatt acattgtgga gcttgtttcc caaataaaag
     2461 atactcacca gaatcatatg gctcaatcaa ccctagtata ttcaacaaag ttgtttttcc
     2521 acatccgctt gggcctatta aagcaaccat ttcgttttct ctaatttgta gggataaatt
     2581 atttaaaact ttcttttttc caaaactctt atcaatattt tttagttgaa tggcaaacat
     2641 attattcttc tcccttcagc atagtgctta gttgttttgt ttcttttaca taaatcatcc
     2701 taaatattat taaaatatcc aataaaacta atagcacata aatagccata gacgtaaagg
     2761 accttgaaag gatcattatt tgaactaatc caaagatata aatcataata aaataaataa
     2821 attcattctt gtatctattg aacaatgaat aacctagtat tttttttaca aaaatttctt
     2881 tttttcgtga aatcaaaata gttaacaata tatagtacga agaaagaata cttatacaaa
     2941 taaccaaaag cagtattgcc acccatacaa ttgaactcga ttgtgaaatc tgtatttgtt
     3001 ctttatatcc ggacattaaa acatttttaa actgtaagtt atttaactct aatccatatt
     3061 ttttaattcc ttcattgatt gctcttttat tttcattaga atcatagata cggacagggt
     3121 ttgatattgc ttgcgtcgtt aaatatccac taaagacttt caaatattta tcattaagac
     3181 aaacaaatac aggatttgta aaaaatgcat ggtcttcatt tgccaattgt aaactttctg
     3241 agaatatttg tttcctatta tctttataat acttgacaca aacatcatct gcactcattt
     3301 taatatttga atctgcggaa taaatttgtg tctgcccaaa atatttcaaa gtagcttctt
     3361 tttgcttcat gctctctgga gcaaatataa ctaaagaatc ttgatcaaaa agttcttctt
     3421 tgcttacact tgaatcaaat tgtaaccgat cataataatt gtcatttaat agcatataac
     3481 caaattctgt atctgtatcc acatcattag gcatttttat ttcagaagag aataaaccta
     3541 aaccttccgt atgataccaa aacgattgta caaaacctgc ctttgcagat tttgttaaat
     3601 ccataaacat attggttaaa ttttcattaa attgacttgt tccattcata aagctttgca
     3661 ttccatctcc agttaattgg aaggaagcaa gcgtcacata atcttcttgc gcctgataag
     3721 cttctttaac ctgcatctct tttatcattc gacttacttc agaagataat tgaggaatgg
     3781 taaataccaa acctacaaaa attgcaaatt ttataatata gctgatatat aaagaaattc
     3841 gaaaatcaaa gaagttttta agcatatttg atattgaata tcgctttact gttattaaag
     3901 ttaaaaatga tagtccaatc gctcctacaa ataaaatcaa ttgaacacaa ctaagtttta
     3961 taaaatagaa taaatccatc gtaggaaatg ctatcttttg aattgggata cttgcgataa
     4021 aaatgataat tggagcaatt aacacatcct tgtttagctt tttccaaata tcaaaagctt
     4081 tatatccatt taacttatat acacttattt cctttagtct agatattgga tagaatacac
     4141 acatcaagca aaaaataatt aatagaatag ctgaaagaat aattgttaaa aaatatatcg
     4201 tcccttctcc aaaagcaact ctataatctg ctgaaaccaa ttcattttta ctttcattta
     4261 aaaataaaga caatgcattt agaatatctt ctttgttttt attactcgaa ataatagtat
     4321 attctccatt aatatcagta gactttgagt tataaaaatc acttaaaggc ataattacaa
     4381 gaggtgtatc attgaataaa tcactaatgg ttcccacttg attttcttgt tttgtatcta
     4441 tagaagccaa ccattcattt gaagtagttg gtaatcgacc tgattctaac tttacaggaa
     4501 gtccttcaaa gaaatctttt gtataaactc ccgatttgta tattatttcc ttgccatctt
     4561 catatattcg atctgttttt attattgttg caccatattg tgaatgaatg gatttcaatt
     4621 cctgcaagaa ttcatcatac gcaacactcg aattcttaac ataaatttta tatgcattgg
     4681 atttcatttc aattgtatta aagaattcaa tatcttgagt tttcatatag aatccaaaag
     4741 caacacttgt taagatagaa acaatgctta atagaattgc catcgatttt ttcataaaac
     4801 ccctcatttt atcaatccat aaaaggttaa attgattttc tttctagacc gttttcttca
     4861 agtatatctt acggccattt agatattctc gctttatacc ataaacacta cataaaacaa
     4921 catctattgt tttgaactat gttattttat gaattattaa aatatagagc gaatataata
     4981 tcgctctata caaatatcaa ttattcaact ccatagtaga acgagcaact agaatatttt
     5041 gttaatcgag ctttggccca tgagtttgct ggagctcttg ccatacttgg agtagcttca
     5101 ggatgactaa ccgtggccgt atgaattttt tgaccatgca tatagtctga ataagaacct
     5161 gtgatgccta cgccatagtt ccactgtcca cctactgcag gatataccgt agttgctaaa
     5221 acaactgatc cactaaaaca tgtaaacaaa atcataatag tacaaactaa ttttctcata
     5281 taaaaactct tctttctaag cactattttg atttaaagtc tatgtcttta tcaagtgctc
     5341 agacaaagac acttttaatt atcgtatcca tcggtatgac ctcctatttt ctatttttta
     5401 ttcattatga aaacacctga ttataatgca tattacattt catcaaacat ttgttcaaaa
     5461 taaaatcaaa aacaattatt tatctgttta acactataga taacgttatc tttattttaa
     5521 ttatacatgt tttgtgattt tatacaagcg ttgatttgtt tttattttct tgttactttt
     5581 tataaggttt gatataattt tattgaaagg agattacttc actatgaatt atacccagtt
     5641 aacaaaaaga gaaagtcaaa taatgactat tctttggaat catgatcaag agatgtcagc
     5701 caatgatatt aaattagctt cggatggatt aagtatctat acaatttctc aagctcttca
     5761 atacctatta tcaattggat atgttgaagt aacaggaata ggtaaaaata aaaaatcgat
     5821 tgctcgatta tatagtcctt gtatttctga atctgactat gtttcctcat tcataaaaaa
     5881 agaaactttc gaagagattg ctgtgcacta tgttcaaagc agcaatgata tagatgaaat
     5941 tacaaagtta gaacatttaa ttgaaaaaaa gaaaaaagaa ctgactggta aataacatga
     6001 attttagcat ttcttcattg ttcataacac tgtgtgtttc attagtccta attgcactct
     6061 tcaattttat attgacgcac gaaaagggct atcgcttgtt tagagcagat ttattattcg
     6121 tattagttgt cattacttgt tttcgtttgt ttttaccatt tgaactacca ttcacaaaga
     6181 caattgctct accttctatc atgaatccta taatgagctt tttaaattat gagatatttc
     6241 atcaattaaa agtctcacat attctaattg taatttggtt aattggagta ttgattggtg
     6301 ttggaagata tgtgcagaat attatattgg caaaaaaact ggaagcgaaa atcatacaaa
     6361 attctcattg cttcaaagtt tcagaatttt tagattgctt catttatcct gattatgacg
     6421 tatatgtaac caaatacgtt ccatctccaa tggtttttgg cttcaaaaaa tgcatcttaa
     6481 ttcctgaaat cagttttaca gaacatgaac taagtaatat tttaaatcat gaaatgcagc
     6541 atctaaagca acatgacata cttttcaaac aagtaacttc aatactaaca atcttgtatt
     6601 ggtggtttcc tccaatatat tggttacaga aatgtatcaa cttttatata gaagttcgag
     6661 cagacgaaaa agttacagaa tcattaaatc cgattgatgc actagattat gcagaaactc
     6721 taataaatgt acaaaagaaa atacagtttg cggatagtat tatatcaaat gatatttcag
     6781 cttatttgat aggagaaagt aacagtatac tttcgtatcg agtgaattat ttattaaaca
     6841 aacaaatcaa acaaaagaca aataagttcc tactattctt ccttttttta ttacctatac
     6901 taactaattc cataattttc gaagcttatt atgaaaatcc aaaaaatttg aatgatactt
     6961 tatctgagca agatctatta aataagaatt atttaatcca gcacaaagat gggacatatt
     7021 ctctttgtaa cggaaaagaa tcctttttca tagataatcc aaaaagttta attgaatccg
     7081 gtataaaagt agtgaaggag taaatttatg aaaaaaacaa ttaattctat tttattatta
     7141 acactaattt taagttgcaa ctttattcaa actatttctg tttttgcaaa cgaaatcggg
     7201 ccaaatccag ccattgaagc aagagcagac atcatagaat ggagatataa gcttgaaaat
     7261 ggaagagtat ataaacgtcg ttataattac actaaacaaa aatggattgg agattggatt
     7321 ccagcataga ttatgacgta gtaacgctta aaaaatagcc taacatcgga aaaatcagaa
     7381 caaagcaaga ctagcagcaa accaatagtt agaagaagtg aaatttctag aaatctatct
     7441 atttataaaa tacatgaagt acaagaatca caaaaatagt tacaccacag actaaaactg
     7501 agatataaaa tacacattca atttctcatc aggaacacgc tctctatatt attggtatca
     7561 atttggtagc aaagtaacct ataaacacat aaaaagtgcc ttatataagg cacttttatt
     7621 cattttacct ctattcgaac tcgtctatgg aaattcttaa atattcgaaa agtacccgtt
     7681 tttggccgtt atttacaggt acaaatgcct aaaaaagcca cttttagaat ccaaataaaa
     7741 agattttttc atatctgttt tcacaaaggc attatccccc taccctttca tcaaaaaatt
     7801 aactatcttt ttcattcact cctttttaca taccagtcaa acgctggata tgtagaaagg
     7861 attttttatt atgatggaat tcatgtttgc tgatttgtgt ttgatgtatc cgcatgctat
     7921 attttcttta aaggaatatg cttccagcat aataatggtg aatatatgaa caatgaaata
     7981 attaaatttg taaatggtga tttggaatta gatgttaata tctctccaaa caagaatact
     8041 gtatggttaa ctgttgatca attatgtact ttattcaata agaacaaatc aacaatttct
     8101 agacatataa aaaatatatt taatgaaggc gaattagatg aatttagctc agttgcaaaa
     8161 aatgcaactc aactaaagcg ctatgatcca cgtactggaa aagatagaat ttcaaatgta
     8221 gaggttaatt attataacct ggatgtaatt atctctgttg gctatcgggt aaaatcacaa
     8281 aatggtgtta ttttcagaaa atgggcaaca tctattcttc atgattacat gctcaaaggt
     8341 tatgcagtaa atcaaaaacg cttagatgtg ttaaataaaa caattgcgat tcaatccaga
     8401 atgcttgctt cgacacttaa tattgaagaa aaagaagtat taagtgttgt tgaagcctat
     8461 tctaatgcat taacgcttct agatgattat gatcatggga ctattcctaa accagatggg
     8521 atagcttcta tttatcactt aacctataaa gaatgtcgtg aattgattga ttctatgaaa
     8581 tatggcaact tttcagatgt atttggtgtt gaaaaagagg aaggaaaact caatggtatc
     8641 ttagcagcta tctaccaaaa tgtttttgga actgaattgt atccaagtat cgaagaaaag
     8701 gctgcaaacc ttctttactt cttaataaaa gaccatccat ttgtagatgg ctgtaaacga
     8761 ataggtgctt ctatatttct tgaattctta aacaagaaca aacatctcat tatcgatgga
     8821 aagcaaatta tttcagacag tgcacttgtt gccattactt taatgattgc agaatccaga
     8881 cctgaagaaa aagaaacaat ggtcaaactg gtaatgaact tcttaaatgc ttagtttttc
     8941 caatacaaaa tgttattctc tcaaatttga ataggaattg agagaatagc attgatgtct
     9001 catatacatt catatatttc atcttacgaa tcagattttg aaaacacgtg ttcactttta
     9061 taaaaattga tttcccctac aacttaatcc tttttacata ccagtcaaac actggatatg
     9121 tagaaaggag ctttttttat gcataaatgt aaagtgattg ccgtcactaa tcaaaaaggc
     9181 ggtgttggta aaactactac gaccgcgaat gttgcgattg gattggaacg atatggctat
     9241 aaagtactga ttgttgattt tgatcctcag ggtgatctaa ccacttccct tggttggaaa
     9301 tccaatgatg ctttggaatg cagcgtttct aatttattgg atgcgtatat taatgataag
     9361 gaaatggact attcttcttt gattttaaaa cataaagaag atgtagatgt gatccctgca
     9421 aacattgaac ttgctgatat ggatattcgt ttagtcagtg tgatcaatcg tgaacagaca
     9481 ttaagcagtt gcattgaacc actacgtgat gactatgatt ttattttgat tgattgtcca
     9541 ccttctttag gaatgcttac cattaatgca ctatccgcag cggatgaagt actgattcca
     9601 gtacaggcac agtttcttcc tgcaaaagga atgactcaat tgttacagac tgtaaataag
     9661 gtgcagcgta aaatcaacac gaacttgaaa gtagctggta ttgtcatgac gcttgtagat
     9721 atgaatacta cagtagccaa aagtacaata gaaaccattc aggaaagctt tggtaaaaac
     9781 atccgagtct ttgatacgat cattccaaaa gcgacaaaag ccagtgaagc aaccatagct
     9841 ggagtcagta tctatgccta cgcaaaggat tcaaaagtgg ctaaagccta tgacaatctg
     9901 acaaaagaaa tcattacaga tcaaaaagta aaacataaag acagagactg tcgttaggag
     9961 aagaacatga aaaataattc cgtccattta attggaacac tgacaagaga tattgaacta
    10021 tctaaaaata gtaaaggcaa ttcttttgtc cgatttactc tagcttgtac aagagataat
    10081 aagccattta ctgattttat taactgtatt gcctttggtg aagttgccaa tgcactttgt
    10141 aaacacagcg ataaagatac agcctatgaa atcaatggat atcttcgtat aagctcttat
    10201 gaaaaagatg gtaaaaagac ctattctacg attgttgttg tggaatcttt tacactctta
    10261 aatgactaga atacgattg
//
