LOCUS       c00018_NZ_FMXR..       11311 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_FMXR01000009.1 Eubacterium oxidoreducens strain DSM 3217, whole
            genome shotgun sequence.
ACCESSION   NZ_FMXR01000009
VERSION     NZ_FMXR01000009
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:24:02
            Original ID  :: NZ_FMXR01000009.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11311
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..249
                     /locus_tag="ctg18_1"
                     /transl_table=11
                     /translation="IRGFCIGKKNWVMIDTVAGAKSSAIAYSIAETAKANHLKPYEYFK
                     HLLTVIPDHMDDTDRSFLEELLPWSDELPAECRKPMK"
     protocluster    1..11311
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[891:1311](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(892..1311)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..11311
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11311
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     PFAM_domain     82..207
                     /aSDomain="DDE_Tnp_IS66_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13817.8"
                     /description="IS66 C-terminal element"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_1_0001"
                     /evalue="2.70E-15"
                     /label="ctg18_1"
                     /locus_tag="ctg18_1"
                     /protein_end="69"
                     /protein_start="27"
                     /score="56.4"
                     /tool="antismash"
                     /translation="SIAETAKANHLKPYEYFKHLLTVIPDHMDDTDRSFLEELLPW"
     CDS             complement(401..892)
                     /locus_tag="ctg18_2"
                     /transl_table=11
                     /translation="MKKRWMRPEVLVENFVPNEYVATCEGSDYYANFTCAIPGSYKNYI
                     GDGIGTVTYNWGSNSDGKKHGSCGETSETSKIMGATTTGGVGYEYRYGEVDRNRPIYNV
                     SIGKSVSSASAKCSTNIGSGSLTPGYHLATWESTDGSTGNYKHYGIAYISKVVTQSNHS
                     "
     CDS             complement(892..1311)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_3"
                     /sec_met_domain="PF05402 (E-value: 6.5e-14, bitscore: 45.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.2e-08,
                     bitscore: 28.3, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKMFYNIVVEVDLIIFQNKFIIYYLKEVFKELLESRCDVDGKESN
                     INRRYRISSGFVLRQIAGEYVIVPIDATSEISNAVMTPNDTAGFLWKEFQEPSTIEDVI
                     KRVEAEYEGNPEQISGDVKEFVIESVNLGILVEVE"
     PFAM_domain     complement(910..1122)
                     /aSDomain="PqqD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05402.14"
                     /description="Coenzyme PQQ synthesis protein D (PqqD)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_3_0002"
                     /evalue="5.20E-11"
                     /label="ctg18_3"
                     /locus_tag="ctg18_3"
                     /protein_end="134"
                     /protein_start="63"
                     /score="42.8"
                     /tool="antismash"
                     /translation="EYVIVPIDATSEISNAVMTPNDTAGFLWKEFQEPSTIEDVIKRVE
                     AEYEGNPEQISGDVKEFVIESVNLGI"
     CDS             complement(1395..2087)
                     /locus_tag="ctg18_4"
                     /transl_table=11
                     /translation="VDGMNLYKKLLELQDLKYRDMQIKIIPSIDAKAIIGVRTPQLKTI
                     AKELRKDDTYKVFLDELPHQYFEENQLHAFIISEMKNLDECLNELEKFLPHVDNWATCD
                     QMSPKIFKKYKTVLLQRIKVWIHSEKTYTVRFGIGMLMKHFLDEDFAPEYPKMVAGLRS
                     KEYYINMMIAWYFATALAKQYESVLPYIEQKRLDDWTHNKAIQKSVESSRITPEQKSYL
                     KSWKVTRR"
     PFAM_domain     complement(1470..2000)
                     /aSDomain="DNA_alkylation"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08713.13"
                     /description="DNA alkylation repair enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_4_0003"
                     /evalue="1.10E-18"
                     /label="ctg18_4"
                     /locus_tag="ctg18_4"
                     /protein_end="206"
                     /protein_start="29"
                     /score="67.9"
                     /tool="antismash"
                     /translation="DAKAIIGVRTPQLKTIAKELRKDDTYKVFLDELPHQYFEENQLHA
                     FIISEMKNLDECLNELEKFLPHVDNWATCDQMSPKIFKKYKTVLLQRIKVWIHSEKTYT
                     VRFGIGMLMKHFLDEDFAPEYPKMVAGLRSKEYYINMMIAWYFATALAKQYESVLPYIE
                     QKRLDDWTHNKAIQ"
     CDS             complement(2129..3997)
                     /gene_functions="other (smcogs) SMCOG1037:heavy metal
                     translocating P-type ATPase (Score: 531.5; E-value:
                     5.6e-161)"
                     /gene_kind="other"
                     /locus_tag="ctg18_5"
                     /transl_table=11
                     /translation="MFDKIEELFEYGGIRKDILLLVVSGLGLIISMLTSNRWNLDMAWL
                     AIILCGIPIVVSAIIGLFRDHDITADVLVALALVAAVFIGEYFAAGEVAFIMQLGSLLE
                     ELTVSRTRSNIENLVKLTPRQARVIRDNHESITPAEKIAVGDIVRVNPGETIPVDGVII
                     KGKTLINQASLTGESLPVDKKEGDEVYSGTLNQYGSFEMRVMKTDENSSIQRMIRLVQA
                     ADVSKAKVVRLADRWAVWIVIIAVVAAVCTFIFTHEIIRSVTILVVFCPCSLVLATPTA
                     IMAAIGNITKHGLLVREGDALERLASVKKIAFDKTGTLTYGKPEVVAIKCSLANWDEAK
                     ICSVVGSIEQKSEHPLGQAIYRYAKARNAYFADVEHFKMLPGRGVAGNLAGVDYLLGNE
                     FLLEDYGILVPEEKKNIAAAYMEKGCTITWISADLECIGFIALADTIRINAHDTIKRIK
                     DCNVEPVLLTGDNKNAAIEIGKKTGISKVQYQCLPEDKMNYIENEMARSERICMIGDGI
                     NDALALKKATVGIAMGKIGSDIAVDAADIVLVNDEIENLPHLIGLSKHMMNIIKVNLTF
                     SMILNFVAIILAITGILNPVVGALVHNAGSVIVIVNSAFLLKWKKR"
     aSDomain        complement(2150..3787)
                     /aSDomain="TIGR01525"
                     /aSTool="tigrfam"
                     /description="ATPase-IB_hvy: heavy metal translocating
                     P-type ATPase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg18_5_0001"
                     /evalue="1.60E-173"
                     /identifier="TIGR01525"
                     /label="ctg18_5"
                     /locus_tag="ctg18_5"
                     /protein_end="616"
                     /protein_start="70"
                     /score="576.5"
                     /tool="antismash"
                     /translation="DVLVALALVAAVFIGEYFAAGEVAFIMQLGSLLEELTVSRTRSNI
                     ENLVKLTPRQARVIRDNHESITPAEKIAVGDIVRVNPGETIPVDGVIIKGKTLINQASL
                     TGESLPVDKKEGDEVYSGTLNQYGSFEMRVMKTDENSSIQRMIRLVQAADVSKAKVVRL
                     ADRWAVWIVIIAVVAAVCTFIFTHEIIRSVTILVVFCPCSLVLATPTAIMAAIGNITKH
                     GLLVREGDALERLASVKKIAFDKTGTLTYGKPEVVAIKCSLANWDEAKICSVVGSIEQK
                     SEHPLGQAIYRYAKARNAYFADVEHFKMLPGRGVAGNLAGVDYLLGNEFLLEDYGILVP
                     EEKKNIAAAYMEKGCTITWISADLECIGFIALADTIRINAHDTIKRIKDCNVEPVLLTG
                     DNKNAAIEIGKKTGISKVQYQCLPEDKMNYIENEMARSERICMIGDGINDALALKKATV
                     GIAMGKIGSDIAVDAADIVLVNDEIENLPHLIGLSKHMMNIIKVNLTFSMILNFVAIIL
                     AITGILNPVVGALVHNAGSVIVIVNSAFL"
     aSDomain        complement(2150..3802)
                     /aSDomain="TIGR01511"
                     /aSTool="tigrfam"
                     /description="ATPase-IB1_Cu: copper-translocating P-type
                     ATPase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg18_5_0002"
                     /evalue="2.00E-128"
                     /identifier="TIGR01511"
                     /label="ctg18_5"
                     /locus_tag="ctg18_5"
                     /protein_end="616"
                     /protein_start="65"
                     /score="427.5"
                     /tool="antismash"
                     /translation="HDITADVLVALALVAAVFIGEYFAAGEVAFIMQLGSLLEELTVSR
                     TRSNIENLVKLTPRQARVIRDNHESITPAEKIAVGDIVRVNPGETIPVDGVIIKGKTLI
                     NQASLTGESLPVDKKEGDEVYSGTLNQYGSFEMRVMKTDENSSIQRMIRLVQAADVSKA
                     KVVRLADRWAVWIVIIAVVAAVCTFIFTHEIIRSVTILVVFCPCSLVLATPTAIMAAIG
                     NITKHGLLVREGDALERLASVKKIAFDKTGTLTYGKPEVVAIKCSLANWDEAKICSVVG
                     SIEQKSEHPLGQAIYRYAKARNAYFADVEHFKMLPGRGVAGNLAGVDYLLGNEFLLEDY
                     GILVPEEKKNIAAAYMEKGCTITWISADLECIGFIALADTIRINAHDTIKRIKDCNVEP
                     VLLTGDNKNAAIEIGKKTGISKVQYQCLPEDKMNYIENEMARSERICMIGDGINDALAL
                     KKATVGIAMGKIGSDIAVDAADIVLVNDEIENLPHLIGLSKHMMNIIKVNLTFSMILNF
                     VAIILAITGILNPVVGALVHNAGSVIVIVNSAFL"
     aSDomain        complement(2216..3718)
                     /aSDomain="TIGR01494"
                     /aSTool="tigrfam"
                     /description="ATPase_P-type: HAD ATPase, P-type, family IC"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg18_5_0003"
                     /evalue="1.20E-76"
                     /identifier="TIGR01494"
                     /label="ctg18_5"
                     /locus_tag="ctg18_5"
                     /protein_end="594"
                     /protein_start="93"
                     /score="256.1"
                     /tool="antismash"
                     /translation="AFIMQLGSLLEELTVSRTRSNIENLVKLTPRQARVIRDNHESITP
                     AEKIAVGDIVRVNPGETIPVDGVIIKGKTLINQASLTGESLPVDKKEGDEVYSGTLNQY
                     GSFEMRVMKTDENSSIQRMIRLVQAADVSKAKVVRLADRWAVWIVIIAVVAAVCTFIFT
                     HEIIRSVTILVVFCPCSLVLATPTAIMAAIGNITKHGLLVREGDALERLASVKKIAFDK
                     TGTLTYGKPEVVAIKCSLANWDEAKICSVVGSIEQKSEHPLGQAIYRYAKARNAYFADV
                     EHFKMLPGRGVAGNLAGVDYLLGNEFLLEDYGILVPEEKKNIAAAYMEKGCTITWISAD
                     LECIGFIALADTIRINAHDTIKRIKDCNVEPVLLTGDNKNAAIEIGKKTGISKVQYQCL
                     PEDKMNYIENEMARSERICMIGDGINDALALKKATVGIAMGKIGSDIAVDAADIVLVND
                     EIENLPHLIGLSKHMMNIIKVNLTFSMILNFVAIILAITGILN"
     PFAM_domain     complement(2420..3073)
                     /aSDomain="Hydrolase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00702.28"
                     /description="haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_5_0005"
                     /evalue="3.10E-29"
                     /label="ctg18_5"
                     /locus_tag="ctg18_5"
                     /protein_end="526"
                     /protein_start="308"
                     /score="102.9"
                     /tool="antismash"
                     /translation="KKIAFDKTGTLTYGKPEVVAIKCSLANWDEAKICSVVGSIEQKSE
                     HPLGQAIYRYAKARNAYFADVEHFKMLPGRGVAGNLAGVDYLLGNEFLLEDYGILVPEE
                     KKNIAAAYMEKGCTITWISADLECIGFIALADTIRINAHDTIKRIKDCNVEPVLLTGDN
                     KNAAIEIGKKTGISKVQYQCLPEDKMNYIENEMARSERICMIGDGINDALALKKA"
     PFAM_domain     complement(3122..3640)
                     /aSDomain="E1-E2_ATPase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00122.22"
                     /description="E1-E2 ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_5_0004"
                     /evalue="6.80E-50"
                     /label="ctg18_5"
                     /locus_tag="ctg18_5"
                     /protein_end="292"
                     /protein_start="119"
                     /score="169.2"
                     /tool="antismash"
                     /translation="KLTPRQARVIRDNHESITPAEKIAVGDIVRVNPGETIPVDGVIIK
                     GKTLINQASLTGESLPVDKKEGDEVYSGTLNQYGSFEMRVMKTDENSSIQRMIRLVQAA
                     DVSKAKVVRLADRWAVWIVIIAVVAAVCTFIFTHEIIRSVTILVVFCPCSLVLATPTAI
                     MAAIGNITKH"
     CDS             4122..4394
                     /locus_tag="ctg18_6"
                     /transl_table=11
                     /translation="MKQCMDSDNLHRRLKKIIGQVNAIDRMVDEDVPCEDVLAQINAAK
                     SALNKVGQVVLEGHITHCIKDAIERGDEKEIKNFTKAIERFANMQ"
     PFAM_domain     4143..4373
                     /aSDomain="Trns_repr_metal"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02583.19"
                     /description="Metal-sensitive transcriptional repressor"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_6_0006"
                     /evalue="1.40E-26"
                     /label="ctg18_6"
                     /locus_tag="ctg18_6"
                     /protein_end="84"
                     /protein_start="7"
                     /score="92.7"
                     /tool="antismash"
                     /translation="DNLHRRLKKIIGQVNAIDRMVDEDVPCEDVLAQINAAKSALNKVG
                     QVVLEGHITHCIKDAIERGDEKEIKNFTKAIE"
     CDS             complement(4466..4876)
                     /gene_functions="regulatory (smcogs)
                     SMCOG1284:transcriptional regulator, MarR family (Score:
                     69.1; E-value: 5.5e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg18_7"
                     /transl_table=11
                     /translation="MDRNIFQNVGILYRSYLNYANSFLKDLGISFSESVVISNIGASEG
                     ITQEGIASLLCIDKAAIARNVKLLETGGLIEIKKNADDKRLKKLYLTQEGWEKYKAITA
                     ANTDRLADLYKGLTPSEISTLETVLNRLADKV"
     PFAM_domain     complement(4622..4798)
                     /aSDomain="MarR_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12802.9"
                     /description="MarR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_7_0007"
                     /evalue="1.50E-09"
                     /label="ctg18_7"
                     /locus_tag="ctg18_7"
                     /protein_end="85"
                     /protein_start="26"
                     /score="37.9"
                     /tool="antismash"
                     /translation="LGISFSESVVISNIGASEGITQEGIASLLCIDKAAIARNVKLLET
                     GGLIEIKKNADDKR"
     CDS             complement(4869..5933)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036:alpha/beta hydrolase fold protein (Score: 66;
                     E-value: 7.5e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_8"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.6e-19, bitscore:
                     63.0, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.5e-15, bitscore: 49.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVVRFLLILICALVLILCGLIIYVATYKNPADKELVEAGIVEK
                     QVQVGSVTFNYAEGPDNGPALVLLHAQLLDWYTYSAVLPELSKGFHVYAIDYPGHGKTI
                     VPEGYVMSAENIGNDLGRFIDEVIGTEVYVTGNSSGGLLATYLAANRGDVVKAVILEDP
                     PLFSSEYPAVKTTVANKAFTQSHNALESEDYDGDYLMYWIDNSKQFFATYVFPGAEKLI
                     KGMVTIYRTFHSDEPLEIAFMPVSVQEMLRGLDYYDPTFGAAFYDGTWNEDFDHEEALK
                     KIDCPVLLIQANTGYLADGTLDGAMSKEMAEVAMDCLSDGKYLYVDSGHVTNLEVPDQF
                     IAIVEDFFLEVENG"
     PFAM_domain     complement(4908..5738)
                     /aSDomain="Abhydrolase_6"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12697.9"
                     /description="Alpha/beta hydrolase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_8_0008"
                     /evalue="1.30E-17"
                     /label="ctg18_8"
                     /locus_tag="ctg18_8"
                     /protein_end="342"
                     /protein_start="65"
                     /score="65.3"
                     /tool="antismash"
                     /translation="LVLLHAQLLDWYTYSAVLPELSKGFHVYAIDYPGHGKTIVPEGYV
                     MSAENIGNDLGRFIDEVIGTEVYVTGNSSGGLLATYLAANRGDVVKAVILEDPPLFSSE
                     YPAVKTTVANKAFTQSHNALESEDYDGDYLMYWIDNSKQFFATYVFPGAEKLIKGMVTI
                     YRTFHSDEPLEIAFMPVSVQEMLRGLDYYDPTFGAAFYDGTWNEDFDHEEALKKIDCPV
                     LLIQANTGYLADGTLDGAMSKEMAEVAMDCLSDGKYLYVDSGHVTNLEVPDQFIA"
     CDS             complement(6405..7667)
                     /NRPS_PKS="Domain: Aminotran_3 (39-353). E-value: 1.2e-71.
                     Score: 233.3. Matches aSDomain:
                     nrpspksdomains_ctg18_9_Aminotran_3.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 296.3;
                     E-value: 6e-90)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_9"
                     /sec_met_domain="Aminotran_3 (E-value: 1.2e-79, bitscore:
                     261.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGITTIQSEQLFEKAQTLMPGGVNSPVRAFKAVGRNPIFIDHAMG
                     SKIVDVDGNEYIDYVCSWGPGILGHAHPIVIDAVTKACAKGLTFGAPTRRESELAELIM
                     AAVPAIEMVRLVSSGTEAVMSAVRAARGYTGRDLILKFTGCYHGHSDGLLVKSGSGLIT
                     NAVPDSAGVPKAYTDCTLVAEYNNEESVRELFGRYGESIAALVVEPVAANMGVVPPEEG
                     FLQFLRDITTKYGTVLIFDEVITGFRLSIGGAAQYYGVKPDLITMGKIIGGGMPLAAYG
                     GRKDIMEVISPLGSVYQAGTLSGNPIATAAGLATLKLLMDDQDIYKRIDDKAAQLEKAY
                     ISAGYKTVNRVGSLMSVFFTDRQVSNYNDAATSDTKAYAEYFGHMLDNGINIAPSQFEA
                     MFISDAHTEDDIRKTIDTIRS"
     aSDomain        complement(6411..7646)
                     /aSDomain="TIGR00713"
                     /aSTool="tigrfam"
                     /description="hemL:
                     glutamate-1-semialdehyde-2,1-aminomutase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg18_9_0004"
                     /evalue="9.40E-177"
                     /identifier="TIGR00713"
                     /label="ctg18_9"
                     /locus_tag="ctg18_9"
                     /protein_end="419"
                     /protein_start="7"
                     /score="585.8"
                     /tool="antismash"
                     /translation="SEQLFEKAQTLMPGGVNSPVRAFKAVGRNPIFIDHAMGSKIVDVD
                     GNEYIDYVCSWGPGILGHAHPIVIDAVTKACAKGLTFGAPTRRESELAELIMAAVPAIE
                     MVRLVSSGTEAVMSAVRAARGYTGRDLILKFTGCYHGHSDGLLVKSGSGLITNAVPDSA
                     GVPKAYTDCTLVAEYNNEESVRELFGRYGESIAALVVEPVAANMGVVPPEEGFLQFLRD
                     ITTKYGTVLIFDEVITGFRLSIGGAAQYYGVKPDLITMGKIIGGGMPLAAYGGRKDIME
                     VISPLGSVYQAGTLSGNPIATAAGLATLKLLMDDQDIYKRIDDKAAQLEKAYISAGYKT
                     VNRVGSLMSVFFTDRQVSNYNDAATSDTKAYAEYFGHMLDNGINIAPSQFEAMFISDAH
                     TEDDIRKTIDTIR"
     PFAM_domain     complement(6465..7565)
                     /aSDomain="Aminotran_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00202.23"
                     /description="Aminotransferase class-III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_9_0009"
                     /evalue="1.40E-77"
                     /label="ctg18_9"
                     /locus_tag="ctg18_9"
                     /protein_end="401"
                     /protein_start="34"
                     /score="261.2"
                     /tool="antismash"
                     /translation="RNPIFIDHAMGSKIVDVDGNEYIDYVCSWGPGILGHAHPIVIDAV
                     TKACAKGLTFGAPTRRESELAELIMAAVPAIEMVRLVSSGTEAVMSAVRAARGYTGRDL
                     ILKFTGCYHGHSDGLLVKSGSGLITNAVPDSAGVPKAYTDCTLVAEYNNEESVRELFGR
                     YGESIAALVVEPVAANMGVVPPEEGFLQFLRDITTKYGTVLIFDEVITGFRLSIGGAAQ
                     YYGVKPDLITMGKIIGGGMPLAAYGGRKDIMEVISPLGSVYQAGTLSGNPIATAAGLAT
                     LKLLMDDQDIYKRIDDKAAQLEKAYISAGYKTVNRVGSLMSVFFTDRQVSNYNDAATSD
                     TKAYAEYFGHMLDNGINIAPSQFEAMF"
     aSDomain        complement(6609..7550)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg18_9_Aminotran_3.1"
                     /evalue="1.20E-71"
                     /label="ctg18_9_Aminotran_3.1"
                     /locus_tag="ctg18_9"
                     /protein_end="353"
                     /protein_start="39"
                     /score="233.3"
                     /tool="antismash"
                     /translation="IDHAMGSKIVDVDGNEYIDYVCSWGPGILGHAHPIVIDAVTKACA
                     KGLTFGAPTRRESELAELIMAAVPAIEMVRLVSSGTEAVMSAVRAARGYTGRDLILKFT
                     GCYHGHSDGLLVKSGSGLITNAVPDSAGVPKAYTDCTLVAEYNNEESVRELFGRYGESI
                     AALVVEPVAANMGVVPPEEGFLQFLRDITTKYGTVLIFDEVITGFRLSIGGAAQYYGVK
                     PDLITMGKIIGGGMPLAAYGGRKDIMEVISPLGSVYQAGTLSGNPIATAAGLATLKLLM
                     DDQDIYKRIDDKAAQLEKAYISAGYKTVNRVGS"
     CDS             complement(7674..8684)
                     /locus_tag="ctg18_10"
                     /transl_table=11
                     /translation="MYMDIKGDIDIMYRFRRLRQTERLRDLVAETRLDVRDFIYPLFVI
                     DGVNITEPVDSMPGVYRYSIDRLDSIIDEVYESGISGILIFGIPKHKDAKGSDAYNPDG
                     IVQRAIRYIKDRHPGLIVIADICLCEYTDHGHCGLISGRTILNDETLPLLAQMAVTTVQ
                     AGADMVAPSDMMDGDVESIRDVLDANGYSNVPIMGYSAKYASGYYSPFRNAAGSAPGFG
                     DRRSYQMDPRNGVEGIREIQNDIEMGADIVMVKPALAYLDVVKEASETFDYPIAVYNVS
                     GEYSMVKAAAEKGWIDEKRIVMENLYAMRRAGASIIITYHALDAAKWMKEIHEGR"
     PFAM_domain     complement(7701..8648)
                     /aSDomain="ALAD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00490.23"
                     /description="Delta-aminolevulinic acid dehydratase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_10_0010"
                     /evalue="7.50E-146"
                     /label="ctg18_10"
                     /locus_tag="ctg18_10"
                     /protein_end="328"
                     /protein_start="12"
                     /score="485.3"
                     /tool="antismash"
                     /translation="YRFRRLRQTERLRDLVAETRLDVRDFIYPLFVIDGVNITEPVDSM
                     PGVYRYSIDRLDSIIDEVYESGISGILIFGIPKHKDAKGSDAYNPDGIVQRAIRYIKDR
                     HPGLIVIADICLCEYTDHGHCGLISGRTILNDETLPLLAQMAVTTVQAGADMVAPSDMM
                     DGDVESIRDVLDANGYSNVPIMGYSAKYASGYYSPFRNAAGSAPGFGDRRSYQMDPRNG
                     VEGIREIQNDIEMGADIVMVKPALAYLDVVKEASETFDYPIAVYNVSGEYSMVKAAAEK
                     GWIDEKRIVMENLYAMRRAGASIIITYHALDAAKW"
     CDS             complement(8718..10283)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_11"
                     /sec_met_domain="TP_methylase (E-value: 1.7e-46, bitscore:
                     152.2, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKRKYVYIAGAGPGNIEYMTVKVKRLLQKCDVIIYDSLVDIEALA
                     LCRTDAEKIYAGKRAGHHSMKQDEISRLIVQKAMEGNTVLRLKGGDPFVFGRGPEECEE
                     LKKNGIPYEVVPGITSAVAVPMAAGIPVTNRNMARSFTVITGHTASGEIKDDIDFEALA
                     HTSGTLVFLMGLGAIGNITDSLIRSGMDENIPAAVISNGTMLNQYVLRGTLGTITDRCK
                     ADSNVISPAIIVVGKVSELNLNSNVRDGLEGINIIACGTMDFCKREEELMQEHGARVTK
                     LPVLQIKEIEQEHKVDQVFSGIINREYGAIAFTGRNAIRIFMERLNKSGVDIRSLYNID
                     ILAIGSSTASYLKEYGINADGIPDEYTSDGLARLIIQRANASKKDEYVIGNKVDSTSRY
                     NVLIPRASKGNDVLASKLQKAGVSFDEIALYDTIANDHISEQIERVCLMDGVYDYITFA
                     SAEGVRLFMQNGGVIPEGVRAVCIGKYTQKALTEAGVYDCIVAQKATAEGIVEAILADH
                     NSCG"
     PFAM_domain     complement(8751..9479)
                     /aSDomain="HEM4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02602.17"
                     /description="Uroporphyrinogen-III synthase HemD"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_11_0012"
                     /evalue="5.80E-46"
                     /label="ctg18_11"
                     /locus_tag="ctg18_11"
                     /protein_end="511"
                     /protein_start="268"
                     /score="156.8"
                     /tool="antismash"
                     /translation="EELMQEHGARVTKLPVLQIKEIEQEHKVDQVFSGIINREYGAIAF
                     TGRNAIRIFMERLNKSGVDIRSLYNIDILAIGSSTASYLKEYGINADGIPDEYTSDGLA
                     RLIIQRANASKKDEYVIGNKVDSTSRYNVLIPRASKGNDVLASKLQKAGVSFDEIALYD
                     TIANDHISEQIERVCLMDGVYDYITFASAEGVRLFMQNGGVIPEGVRAVCIGKYTQKAL
                     TEAGVYDCIVAQKATAEGIVE"
     aSDomain        complement(9561..10271)
                     /aSDomain="TIGR01469"
                     /aSTool="tigrfam"
                     /description="cobA_cysG_Cterm: uroporphyrinogen-III
                     C-methyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg18_11_0005"
                     /evalue="1.20E-89"
                     /identifier="TIGR01469"
                     /label="ctg18_11"
                     /locus_tag="ctg18_11"
                     /protein_end="241"
                     /protein_start="4"
                     /score="298.1"
                     /tool="antismash"
                     /translation="YVYIAGAGPGNIEYMTVKVKRLLQKCDVIIYDSLVDIEALALCRT
                     DAEKIYAGKRAGHHSMKQDEISRLIVQKAMEGNTVLRLKGGDPFVFGRGPEECEELKKN
                     GIPYEVVPGITSAVAVPMAAGIPVTNRNMARSFTVITGHTASGEIKDDIDFEALAHTSG
                     TLVFLMGLGAIGNITDSLIRSGMDENIPAAVISNGTMLNQYVLRGTLGTITDRCKADSN
                     VISPAIIVVGKVSEL"
     PFAM_domain     complement(9633..10268)
                     /aSDomain="TP_methylase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00590.22"
                     /description="Tetrapyrrole (Corrin/Porphyrin) Methylases"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_11_0011"
                     /evalue="1.20E-43"
                     /label="ctg18_11"
                     /locus_tag="ctg18_11"
                     /protein_end="217"
                     /protein_start="5"
                     /score="149.6"
                     /tool="antismash"
                     /translation="VYIAGAGPGNIEYMTVKVKRLLQKCDVIIYDSLVDIEALALCRTD
                     AEKIYAGKRAGHHSMKQDEISRLIVQKAMEGNTVLRLKGGDPFVFGRGPEECEELKKNG
                     IPYEVVPGITSAVAVPMAAGIPVTNRNMARSFTVITGHTASGEIKDDIDFEALAHTSGT
                     LVFLMGLGAIGNITDSLIRSGMDENIPAAVISNGTMLNQYVLRGTLGTI"
     CDS             complement(10283..11248)
                     /locus_tag="ctg18_12"
                     /transl_table=11
                     /translation="MNIIRVGTRGSALALKQVQIVADLIHEKHPEIEIQNVIIKTSGDK
                     ITDKSLAAIGGKGLFLKEIEERLAAGDIDIAVHSGKDMPSYTPEPFIIPAVLPREDDAD
                     LFIIADRNTNPDARKALEYISNLQNIEDAEIHNNMNFNITIGTSSPRREELIKRLLPGS
                     STTLLRGNVPTRLTKLAVGECDATLLASAGIKRLGINLAENGIIAVPVPDEYMIPASCQ
                     GIIAVETIKGNPVADIISEINDANTKFIFDHERALMKMLNADCHDAAAVNIKYLSETKN
                     HIKISAFYKNSDIAVRTCNIEEIDTAVDDIREQIKLRKNN"
     PFAM_domain     complement(10550..11239)
                     /aSDomain="Porphobil_deam"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01379.22"
                     /description="Porphobilinogen deaminase, dipyromethane
                     cofactor binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_12_0013"
                     /evalue="9.20E-60"
                     /label="ctg18_12"
                     /locus_tag="ctg18_12"
                     /protein_end="233"
                     /protein_start="3"
                     /score="201.8"
                     /tool="antismash"
                     /translation="IRVGTRGSALALKQVQIVADLIHEKHPEIEIQNVIIKTSGDKITD
                     KSLAAIGGKGLFLKEIEERLAAGDIDIAVHSGKDMPSYTPEPFIIPAVLPREDDADLFI
                     IADRNTNPDARKALEYISNLQNIEDAEIHNNMNFNITIGTSSPRREELIKRLLPGSSTT
                     LLRGNVPTRLTKLAVGECDATLLASAGIKRLGINLAENGIIAVPVPDEYMIPASCQGII
                     AVETIKGN"
ORIGIN
        1 atccgtggct tctgcatagg caagaagaac tgggtgatga ttgatactgt tgcaggcgct
       61 aagtccagtg caatcgctta cagtattgct gaaacagcaa aggcaaacca cttgaagcct
      121 tatgagtatt tcaaacactt actcacagta attcctgatc acatggatga tacggatcga
      181 agcttcctag aagaacttct tccttggtca gatgaattac cagctgagtg cagaaaacca
      241 atgaagtaaa tgtcacgact acgggcgtga cttaattaaa aggaggtacc ggtggtttac
      301 cggttacgtt atttctatca tcataacaca aaaagaatgc cactggggca ttctccgact
      361 gcatcaaaaa cgaccgacac ttgtcggccg tttttaaatc ctatgaatga ttagactggg
      421 ttacaacttt tgaaatataa gcgattccat aatgcttata attaccggta cttccatccg
      481 tactttccca ggttgcaaga tggtatcccg gagtcagact gccgctaccg atattggtgg
      541 aacatttcgc acttgcactt gaaacgctct ttccaattga cacattataa atcggtctgt
      601 ttctatcaac ctcaccgtaa cggtattcat aaccgactcc accggttgtt gtcgctccca
      661 taatcttgga agtttctgaa gtctctccac agcttccatg tttcttacca tctgaattcg
      721 aaccccaatt ataggttacc gtgccaattc catccccaat ataattctta taagatcccg
      781 gaatcgcaca tgtaaaattc gcataataat cagaaccttc acatgttgcc acatactcat
      841 ttggaacaaa attctcaact aaaacttcag gtctcatcca ccgttttttc attactctac
      901 ctccactaaa attcctaaat tcactgactc aatcacaaac tcttttacat ccccgctaat
      961 ctgttccgga ttcccttcat actcagcttc cactcttttt atgacatcct ctatggtact
     1021 tggctcttga aattctttcc acaaaaatcc cgccgtatca ttcggtgtca taacagcatt
     1081 ggaaatctca cttgttgcat caattggaac aattacatat tctcctgcaa tctgtctaag
     1141 tacaaaccca gagctgatgc gatatctacg attgatgttg ctttctttgc cgtccacatc
     1201 acacctgctt tccaatagtt ccttaaatac ttctttcaaa taataaatta taaacttatt
     1261 ttgaaagatt atcaagtcta cttctacaac aatattataa aacattttca tgcaaaatcc
     1321 aatcataata ccgttttttc tacatagtat tcatttttgt atctcttttg gctgcattat
     1381 tgccgacctg tctattatct gcgagtcacc ttccatgatt ttaaataact tttttgttcc
     1441 ggtgtaatcc tgctgctctc cacacttttt tgaatcgctt tgttatgcgt ccagtcatct
     1501 agcctttttt gttctatata tggaagtacg ctttcgtatt gcttagctaa agcagttgca
     1561 aaataccatg caatcatcat attgatgtaa tactctttac ttcttaatcc ggcaaccatc
     1621 ttcggatact ccggcgcaaa atcttcatct agaaaatgct tcatcagcat ccctattcca
     1681 aatcttactg tataagtttt ctcagaatga atccacacct ttatgcgttg caaaagtacc
     1741 gtcttatact ttttaaaaat tttcggtgac atctgatcac aggtagccca gttatccaca
     1801 tgcggcagga atttttccag ctcgttcaaa cactcatcta gatttttcat ctctgagatt
     1861 ataaacgcat gcaattggtt ttcttcaaaa tactgatgtg gcaattcatc caaaaacacc
     1921 ttatatgtgt catcttttct taattctttt gcaattgtct taagctgcgg cgtccttacg
     1981 ccaattatgg cctttgcatc tatcgaagga atgatcttga tttgcatatc gcgatattta
     2041 aggtcttgaa gttccaacaa tttcttgtac aaattcatgc cgtccacttg catcctcccc
     2101 tttcacaaag ctttgcattt atatcttttt accttttctt ccatttgagc aaaaatgcag
     2161 aattcacaat tacaattacc gaacctgcat tatgtaccaa tgctcctact acaggattta
     2221 atattcccgt gattgccaag atgattgcca caaaattaag gatcatcgaa aatgtaagat
     2281 ttaccttgat tatgttcatc atatgcttag aaagaccaat caggtgtgga agattctcga
     2341 tttcatcgtt tacaagcact atatctgctg catccactgc tatatcagaa cctattttcc
     2401 ccattgcaat cccaaccgtt gcttttttta atgccaaagc gtcattaata ccgtctccta
     2461 tcatacagat tctttcgctt ctagccatct cattttcaat ataattcatc ttatcttcag
     2521 gcagacattg atactgaact tttgatatgc cggttttctt tccaatttca atggccgcat
     2581 tcttattatc gccggttaac aaaacaggct ctacgttaca atccttaatt ctttttattg
     2641 tatcatgcgc atttatccta atggtatctg ccagcgctat aaatcctata cactccaaat
     2701 cggcactaat ccatgtaatc gtacaccctt tttccatgta cgcggcggct atattctttt
     2761 tttcttctgg tactaggatt ccataatctt ctaataagaa ttcatttccc agtaaatagt
     2821 ctactcctgc aaggttgcct gcaacgcctc ttcctggaag cattttaaaa tgttcaacat
     2881 ctgcaaaata tgcgtttcta gcttttgcat accggtaaat tgcctgacct aatggatgct
     2941 ccgatttttg ttcaatactt cccaccacac tacatatctt agcttcatcc cagttcgcta
     3001 aactgcactt aatggccacc acttccggtt ttccataggt taacgttcca gtcttatcaa
     3061 aagcaatctt tttgacggaa gctaatcttt ctaaggcatc cccttctcta accagcaatc
     3121 catgttttgt gatatttcca atggctgcca taattgccgt tggggtagca agcacaagcg
     3181 agcacggaca aaagacaacc aatattgtaa ccgatcgaat tatttcatgt gtaaaaataa
     3241 aagtacaaac agccgctacc actgcaataa ttacaatcca taccgcccat ctgtccgcaa
     3301 gacgcactac cttcgcttta ctaacatctg ccgcttgaac caaccgaatc attctttgaa
     3361 tagaactatt ctcatccgtt ttcataactc tcatttcaaa tgagccatac tgattcaaag
     3421 ttccactgta tacctcatcc ccttccttct tatccacagg aagcgattcg cctgtaaggc
     3481 tcgcctgatt aattaaggtt tttcccttta taatcacccc atctacagga attgtctcac
     3541 ccggattcac tctaacaata tcccccaccg caatcttttc tgccggagta atgctctcat
     3601 gattgtcacg tatcaccctt gcttggcgag gtgtcagttt taccagattt tctatattcg
     3661 atctcgttct agaaacagtc aactcttcaa gaaggctacc taattgcata ataaaggcga
     3721 cctcacctgc tgcaaaatat tctccaataa aaaccgctgc taccagtgca agcgcaacta
     3781 atacatctgc cgtgatatca tgatctctaa atagtcctat tattgcggaa accacaatag
     3841 gaataccgca taaaataata gccagccatg ccatatccag attccaacga ttacttgtaa
     3901 gcatactgat tatcaaccct aatccagaaa caacaagcaa taggatatct tttcttatac
     3961 ctccatattc aaataattct tctattttgt caaacatact ctcctctttc catacccata
     4021 ggggtatatg taatttcgcc ctcattatac ccataggggt atgtgcatgt caaccataat
     4081 cgtgtatgat ggatttagat tatataattc ggaggagtac tatgaaacag tgtatggatt
     4141 cagacaatct tcatagaaga cttaagaaaa taattggtca ggttaacgca attgacagaa
     4201 tggtcgatga ggatgttcct tgtgaggatg ttcttgcaca gattaatgct gcgaaatccg
     4261 cgcttaataa agtagggcag gttgtcttag aagggcatat tactcattgt atcaaggatg
     4321 ctattgaacg tggggatgaa aaagaaataa agaattttac caaagcaatt gaacgctttg
     4381 ccaatatgca gtaataacca tttcagacgt gaataccgaa gtgtccggca acaagatgaa
     4441 gatgagttct tttttcgata atccgctata ctttatctgc caacctattc agcaccgtct
     4501 ccagtgtact gatttcggaa ggagtgagtc ccttatacag gtcagccagg cggtctgtgt
     4561 tggctgccgt aatagcctta tacttttccc atccctcttg ggtcaggtaa agtttcttta
     4621 aacgcttatc atctgcattt ttctttattt cgatcaagcc cccggtttca agaagcttta
     4681 cgtttctcgc aatggcagcc ttatcaatgc acagaagtga ggcaatacct tcctgtgtga
     4741 tcccttccga tgcacctata tttgatatca caacactttc tgaaaaggaa attcctaaat
     4801 cctttaagaa gctatttgca taattcaaat agcttctata caggattcca acgttttgaa
     4861 aaatgtttct atccattctc tacctccaag aaaaaatctt ctacaatagc gataaactga
     4921 tccggtacct caagatttgt tacgtggccc gagtccacat ataagtattt tccatcgctg
     4981 aggcaatcca tagccacttc tgccatttcc tttgacatcg ccccatccag ggttccatca
     5041 gccagataac ctgtgttggc ctgaatcaac aacaccggac agtctatctt ctttagcgct
     5101 tcctcatgat cgaaatcctc attccaagtg ccatcataga aggcagctcc aaaagttgga
     5161 tcataatagt ccagcccacg cagcatttcc tgaactgaca caggcatgaa ggcaatctca
     5221 agaggctcat cactgtggaa ggtgcgatag atggtcacca tacccttaat taatttttct
     5281 gctcctggaa acacatatgt ggcaaagaac tgcttgctgt tatcaatcca gtacatgagg
     5341 taatcgccat catagtcctc tgactccaaa gcattgtggc tctgggtaaa agctttattg
     5401 gcaacagttg tcttaacagc aggatactcc gacgaaaata gaggaggatc ttccaatatt
     5461 accgctttca ccacatcgcc tctgttagcc gcaagatatg tagctagaag cccccctgat
     5521 gagttgccgg tcacataaac ttccgtgccg ataacctcat cgatgaagcg gcctagatca
     5581 tttcctatgt tttcggcgct catcacgtag ccttctggta ctatagtctt gccatgtccc
     5641 ggatagtcga tagcgtatac atgaaagcct tttgaaagct ccggcagaac agcgctgtac
     5701 gtgtaccagt ccagtagttg tgcgtgaagt aggacaagag ccggaccgtt atcaggtcct
     5761 tcagcatagt taaaggttac gctgcccacc tgcacctgct tttccactat tcccgcctcg
     5821 accagttctt tgtccgcagg atttttatat gttgcaacat aaatgatcag tccacacaat
     5881 atcagtacaa gtgcgcagat cagtattaaa agaaatctta ccactttttt catttcttgg
     5941 tctccacaaa caaattgact gagtcaacca tatattatat tgttgactca gtcaagtatt
     6001 taaaaatatt tttttatcca agtttgataa cctggaagat attatttata atgcctcttc
     6061 aaaagtttat gatgccaaat gaccctaaca actgtaggag caataactcc tgcaatcaaa
     6121 gaaattcaag agtactggcc atcgatttct ttcatgcctc ttgttactat atctttagta
     6181 tcgtctttcc cttcgatcca ccggaagcca ctttcttcag tgccttgttc actacttttt
     6241 ttactttcta tttttgtaaa tcaactgctc ctggcagtat cctgccttta aagttctcgc
     6301 agtcgcattc cccatggaac aagagcatgc tgaccttccc tgtcatacca tttgtatctt
     6361 ctactgtcta agaaaaaaat gacgatgata tgtattgtca aagtttagga acgtatagta
     6421 tctatcgtct tacgaatatc gtcttcagtg tgtgcatcgc ttataaacat tgcctcaaac
     6481 tgggatggag ctatattaat accattgtcc agcatgtgac caaaatattc tgcataggct
     6541 tttgtatctg aagttgcagc atcattataa tttgatacct gcctgtctgt aaaaaataca
     6601 ctcataagag agccaactct gttaaccgtc ttataaccgg ctgatatata tgctttttcc
     6661 agctgtgctg ccttatcatc tattctctta taaatgtcct gatcatccat taatagctta
     6721 agtgttgcaa gtcctgctgc cgtagctata ggattgccgg aaagagtacc tgcctggtac
     6781 acactgccaa gtggagatat aacttccata atatcctttc tgccgccata tgcagctagt
     6841 ggcattcctc ctccaattat cttgcccata gtaatgagat ccggctttac tccatagtac
     6901 tgcgcggcac cacctattga gagcctaaat cctgttataa cttcatcaaa tatcagaact
     6961 gttccatatt tagtagttat atctctaagg aactgtagaa atccttcctc aggtggtaca
     7021 acacccatgt tagcagcaac tggctctaca acaagggctg caattgattc tccatatcgg
     7081 ccaaataact ctcttactga ttcttcatta ttatattctg caacaagtgt acagtctgtg
     7141 tatgctttgg gaacaccggc actatcaggt actgcattag ttattagtcc agatcctgac
     7201 tttaccagta ggccatctga atggccatgg tagcatcctg taaacttcaa aatcaaatct
     7261 cttcctgtat atccacgtgc ggcccttaca gcactcatta cagcctctgt tccagagctt
     7321 acaagtctta ccatttctat tgctggaaca gcagccatta tcagttctgc aagttctgat
     7381 tctcttctgg taggtgctcc aaatgtaagc ccctttgcac atgcctttgt aacagcatct
     7441 attactatag gatgtgcatg tcccagaata cctggtcccc atgagcagac ataatcaata
     7501 tattcattac catcaacatc tacaatctta ctgcccatgg catgatctat aaatatcgga
     7561 ttacgtccaa ctgccttgaa tgctcttact ggagagttga ctccgcctgg cataagtgtc
     7621 tgtgcttttt caaataactg ttctgattgt atagttgtaa ttcccattat tttttatctt
     7681 ccttcatgta tctctttcat ccatttggct gcatcaagtg catgataggt aatgattatg
     7741 gatgccccgg ctctcctcat tgcatagaga ttctccataa ctattctctt ctcatcaatc
     7801 cagccctttt ctgcagcagc cttaaccatg gaatattcac cgcttacgtt atatacagca
     7861 attggataat caaatgtttc tgatgcttct tttacaacat ctagataagc aagagctggc
     7921 ttgaccatta ctatatccgc tcccatttct atatcatttt gtatctctct tatgccttca
     7981 acaccatttc taggatccat ctgataagat cttctgtctc caaaacctgg tgcagatccg
     8041 gctgcatttc taaatggcga ataatatcct gaagcatatt tggcactata acccattatt
     8101 ggaacattac tgtatccgtt ggcatcgagt acatcacgaa tggattctac atctccatcc
     8161 atcatatcag atggcgcaac catatcagct cctgcctgca cggtggtaac agccatctgt
     8221 gccaaaagag gtagtgtctc atcattaagt attgttctgc cgcttataag accgcagtga
     8281 ccgtgatctg tatattcaca caggcatata tcagctatta ctataagacc tggatgccta
     8341 tccttaatat atctgatagc cctctgcact attccatctg gattataggc atcgcttccc
     8401 tttgcatcct tatgcttagg tattccaaat ataagaatac ctgaaatacc gctttcatat
     8461 acttcatcaa ttatagaatc tagtctgtct atagaatatc tgtatactcc aggcatagaa
     8521 tctacaggct cagttatgtt tactccatct attacaaaaa gaggatatat aaaatctctt
     8581 acatcaagtc ttgtctcagc cacaagatct cttaatcttt ctgtttgtct aagtcttcta
     8641 aatctgtaca taatatcaat atctcccttt atatccatat acatgctgca tttatagaca
     8701 tatactatta tccataatca tccgcagcta ttgtgatcag ccagtattgc ctccacaatt
     8761 ccttctgcag tagccttctg agctacaata caatcatata ctccagcctc cgtaagagcc
     8821 ttttgtgtat acttaccaat gcaaacagct cttacacctt ctggtattac tccgccattt
     8881 tgcataaata gtcttacacc ctctgcactt gcaaaagtta tatagtcata aactccatcc
     8941 atcaaacata cacgttctat ctgttctgat atatggtcat ttgcaatcgt atcatataat
     9001 gctatttcat caaatgatac acctgctttt tgcaatttag atgcaagaac atcatttccc
     9061 tttgaagctc ttggtatgag tacattgtat ctgcttgttg aatcaacttt attaccgata
     9121 acatactcat cttttttact tgcattagct ctttgaatta tgagcctagc cagtccatcc
     9181 gaagtgtatt catcaggaat tccatcagca tttattccat attccttaag atagctggct
     9241 gtactacttc caattgcaag aatatctata ttataaaggc ttctgatatc tactccgctc
     9301 ttattaagcc tttccatgaa tatcctaatg gcatttctac ctgtaaaagc tatagctcca
     9361 tattctctgt tgataatacc cgaaaacact tggtctactt tatgttcttg ttctatttct
     9421 ttaatctgta aaacaggtaa tttagttact cttgccccat gctcctgcat aagttcttct
     9481 tctcttttac agaaatccat tgttccgcag gcaataatat ttatgccttc aagaccatct
     9541 cttacattgc tgttaagatt aagttccgat accttgccta caacaattat tgcaggtgag
     9601 ataacattag aatccgcctt acatctatcc gtaatagtac ccagagttcc tcttagtaca
     9661 tactgattga gcatagttcc attacttata actgctgcag ggatattctc atccattcct
     9721 gatctgataa ggctatctgt aatatttcct attgctccca gtcccattag gaataccagc
     9781 gttccactcg tatgtgcaag tgcttcaaaa tctatatcat ccttaatctc tccacttgca
     9841 gtatgtccag ttattactgt aaaagacctt gccatatttc tgttagttac aggaatacct
     9901 gcagccatag gaactgccac agcagaagtt attcccggaa cgacttcata tggaatccca
     9961 tttttcttaa gttcttcaca ctcttccgga cctctcccaa aaacaaatgg gtctccgcct
    10021 tttagcctta gtacagtatt tccttccata gccttttgta ctataagcct gctaatttca
    10081 tcctgtttca tagaatggtg tccggctctc ttaccggcat atattttttc tgcgtctgtg
    10141 cggcacaatg caagagcctc tatatctaca aggctgtcat atataattac gtcacatttc
    10201 tgcaagagcc ttttgacctt aaccgtcata tattcaatat ttccaggtcc cgctcctgct
    10261 atatatacat attttctttt cactaattat ttttccttaa tttaatctgt tctctaatat
    10321 cgtctacagc tgtatctatt tcttctatat tgcaggttct aactgctata tcactatttt
    10381 tataaaaagc tgatatctta atatgatttt ttgtttcaga caggtatttg atattaacag
    10441 ctgctgcatc atgacagtct gcatttaaca ttttcattag agctctttca tgatcaaaaa
    10501 taaatttagt gtttgcatca tttatttctg aaataatgtc tgctacagga tttcctttaa
    10561 ttgtctctac agctattatc ccctggcatg aagccggaat catatattca tcaggaacag
    10621 ggacagcaat tattccgttt tctgcaagat taattccaag tctcttaatt ccagctgatg
    10681 ctagtagtgt tgcatcacat tctcctactg caagtttggt cagccttgta ggaacattac
    10741 ctcttagaag tgtagtactg cttccaggca gaagtctctt aataagctct tctcttctgg
    10801 gacttgaagt tccgatagta atattaaaat tcatattatt atggatttca gcatcttcta
    10861 tattctgcag attactaata tattcaagcg cttttctagc atctggattt gtattacgat
    10921 ctgcaatgat aaacaaatca gcatcatctt ctcttggaag cacagctgga attataaatg
    10981 gttcaggtgt ataagatggc atatccttac cactatgaac agcaatatct atatcacctg
    11041 ctgcaaggcg ctcttctatc tctttgagga agagtccttt accgccaatt gcagcaagcg
    11101 atttatctgt tatcttatct ccgcttgtct tgataattac attttgaatt tctatttccg
    11161 gatgtttctc atgaataagg tctgcgacta tctgcacttg tttaagagcc agcgcgcttc
    11221 cccttgtacc aactctgata atattcatac ctgtcctcat atcttgaaat aattaccccg
    11281 catttatcag ttcatttagt agttctctta a
//
