Select genomic region:
Overview
1.1
18.1
18.2
18.3

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LT546011.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS-like | 1 | 6,161 |

NZ_LT546028.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 18.1 | T1PKS | 354,674 | 399,401 | bacillomycin D | Polyketide + NRP:Lipopeptide | 20%
Region 18.2 | RiPP-like | 930,867 | 941,160 |
Region 18.3 | terpene | 1,226,140 | 1,247,033 | carotenoid | Terpene | 62%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS-like | 1 | 6,161 |
Region 18.1 | T1PKS | 354,674 | 399,401 | bacillomycin D | Polyketide + NRP:Lipopeptide | 20%
Region 18.2 | RiPP-like | 930,867 | 941,160 |
Region 18.3 | terpene | 1,226,140 | 1,247,033 | carotenoid | Terpene | 62%

No secondary metabolite regions were found in these records:
  NZ_LT546012.1
  NZ_LT546013.1
  NZ_LT546014.1
  NZ_LT546015.1
  NZ_LT546016.1
  NZ_LT546017.1
  NZ_LT546018.1
  NZ_LT546019.1
  NZ_LT546020.1
  NZ_LT546021.1
  NZ_LT546022.1
  NZ_LT546023.1
  NZ_LT546024.1
  NZ_LT546025.1
  NZ_LT546026.1
  NZ_LT546027.1

Compact view
NZ_LT546011.1 - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 6,161 nt. (total: 6,161 nt) Show pHMM detection rules used
Region on contig edge.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.31 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.29 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001249.1 |  | 0.27 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000900.1 |  | 0.27 | Other | ferrichrome | Aspergillus oryzae
BGC0000979.1 |  | 0.24 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.24 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000348.1 |  | 0.24 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001479.1 |  | 0.23 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001718.1 |  | 0.21 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0001517.1 |  | 0.21 | NRP | asperphenamate | Aspergillus terreus NIH2624

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.65 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.62 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001249.1 |  | 0.61 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000900.1 |  | 0.61 | Other | ferrichrome | Aspergillus oryzae
BGC0000979.1 |  | 0.58 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.58 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000348.1 |  | 0.57 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001479.1 |  | 0.56 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001718.1 |  | 0.54 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0001517.1 |  | 0.54 | NRP | asperphenamate | Aspergillus terreus NIH2624

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 6161:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_6: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (30..387): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAESIGtVvK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      80% (moderate)

NZ_LT546028.1 - Region 1 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 354,674 - 399,401 nt. (total: 44,728 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001909.1 |  | 0.32 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001831.1 |  | 0.24 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001161.1 |  | 0.21 | Polyketide | 1-heptadecene | Moorea bouillonii PNG
BGC0001162.1 |  | 0.21 | Polyketide | 1-heptadecene | Moorea producens JHB
BGC0001163.1 |  | 0.21 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0000044.1 |  | 0.21 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001264.1 |  | 0.19 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  | 0.19 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001458.1 |  | 0.19 | Other (Aminocoumarin) | salinipostin G | Salinispora tropica CNB-440
BGC0001897.1 |  | 0.19 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001909.1 |  | 0.65 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001831.1 |  | 0.57 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001161.1 |  | 0.54 | Polyketide | 1-heptadecene | Moorea bouillonii PNG
BGC0001162.1 |  | 0.54 | Polyketide | 1-heptadecene | Moorea producens JHB
BGC0001163.1 |  | 0.54 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0000044.1 |  | 0.54 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001264.1 |  | 0.51 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  | 0.51 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001458.1 |  | 0.51 | Other (Aminocoumarin) | salinipostin G | Salinispora tropica CNB-440
BGC0001897.1 |  | 0.51 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 354673 - 399401:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg18_346: mal
  PKS_AT (630..922): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 54.2%
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 89.6
    Methoxymalonyl-CoA: 63.4
    Methylmalonyl-CoA: 60.9
    Malonyl-CoA: 42.1
    Ethylmalonyl-CoA: 41.1
    Propionyl-CoA: 37.7
    Acetyl-CoA: 28.7
    trans-1,2-CPDA: 25.0
    2-Methylbutyryl-CoA: 24.2
    Isobutyryl-CoA: 14.2
    inactive: 12.3
    CHC-CoA: 8.0
    Benzoyl-CoA: 4.8
    3-Methylbutyryl-CoA: 0.0
ctg18_347: pk
  CAL_domain (67..526): pk
  minowa: AHBA
  Prediction, score:
    AHBA: 23.9
    Acetyl-CoA: 23.2
    shikimic_acid: 17.8
    NH2: 13.6
    fatty_acid: 0.0

NZ_LT546028.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 930,867 - 941,160 nt. (total: 10,294 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000801.1 |  | 0.14 | Saccharide | galactoglucan | Sinorhizobium meliloti
BGC0000709.1 |  | 0.07 | Saccharide | neomycin | Streptomyces fradiae ATCC 10745 = DSM 40063

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000801.1 |  | 0.44 | Saccharide | galactoglucan | Sinorhizobium meliloti
BGC0000709.1 |  | 0.29 | Saccharide | neomycin | Streptomyces fradiae ATCC 10745 = DSM 40063

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT546028.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,226,140 - 1,247,033 nt. (total: 20,894 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.1 |  | 0.35 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000637.1 |  | 0.34 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0000647.1 |  | 0.32 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000644.1 |  | 0.32 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000640.1 |  | 0.20 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000656.1 |  | 0.18 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000641.1 |  | 0.18 | Terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.1 |  | 0.18 | Terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000638.1 |  | 0.18 | Terpene | carotenoid | Pantoea ananatis
BGC0000642.1 |  | 0.18 | Terpene | carotenoid | Enterobacteriaceae bacterium DC413

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.1 |  | 0.68 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000637.1 |  | 0.67 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0000647.1 |  | 0.66 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000644.1 |  | 0.65 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000640.1 |  | 0.52 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000656.1 |  | 0.50 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000641.1 |  | 0.50 | Terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.1 |  | 0.50 | Terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000638.1 |  | 0.49 | Terpene | carotenoid | Pantoea ananatis
BGC0000642.1 |  | 0.49 | Terpene | carotenoid | Enterobacteriaceae bacterium DC413

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names