LOCUS       NC_022571.1            20669 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_022571.1 Clostridium saccharobutylicum DSM 13864, complete
            sequence.
ACCESSION   NC_022571
VERSION     NC_022571.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:03:18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4052236
            Orig. end    :: 4072905
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..2331)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:diguanylate cyclase (Score: 167.6; E-value:
                     1e-50)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3597"
                     /transl_table=11
                     /translation="MDKYVKWSFVFGVICFLLYFIAAIFKSNLWGDILSPLGTLSSFII
                     LLHVYKKSERMKNVWLMPSIAALIWTFSDIIWAICEILMGINPDNMTIFTLLYLFPNIC
                     IMTSGLIYMKKFIKGANAVQLLLDIFVISTSCLVMFWFLFLKENIFLFIKDVNNILSFI
                     YVITDFIIINWVIIWFFSVRRGKVTKGMYITLLGATIYAANDLVCTYEYFYHLYVPNSI
                     PDTIYLLSFLIIAFGGISVLQYNNCKWAYEFYSQTKNIGNTKKSLILLLTIPIYIIFKG
                     FDFDKILILFLIFTIYEIASNYVQKAINNEKLLNDEKNINLILEEKIKERTKELLLKND
                     DLEYTSYHDFITNVYNGRYLKKRLDDIIDQKISNQKITIYYIDVDRFKTINDTYGHDIG
                     DSLLIEIAQRLQKETDENSIVARLGGDEFVIVIEGDLSEDEVEKFAQKITTSCNESIYI
                     ENYEFNITISIGIASFPTDATSRNVVMKNADMAMYYAKSKGQNKYEIFNSNISNLILEK
                     NEIELLLKNADYNNEFQLYYQPQIDINTNELVGMEALIRWNSPIKGNISPNKFIKIAEE
                     TGSIEKISDWVMNTAAKQIGIWNKKFGLNMKMGINISPNQLDSIKFAHKLEKILEEYDL
                     NSDWIDIEITENIAMKGEATLGKIFSMLSSMGISTSIDDFGTGYSSLSYIQQFSFDRLK
                     IAKELIDNIVTDLSKRHIVKAIVMLAEALNVLTIAEGIETKEQLEVIKEIGCNQVQGYI
                     FSKPLTADMFEENFLAVEKVEIQ"
     protocluster    1..20669
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[4062141:4063587](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(9906..11351)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..20669
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..20669
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="9"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /tool="antismash"
     PFAM_domain     complement(61..744)
                     /aSDomain="EAL"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00563.22"
                     /description="EAL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3597_0251"
                     /evalue="1.20E-65"
                     /label="ctg1_3597"
                     /locus_tag="ctg1_3597"
                     /protein_end="757"
                     /protein_start="529"
                     /score="221.4"
                     /tool="antismash"
                     /translation="NNEFQLYYQPQIDINTNELVGMEALIRWNSPIKGNISPNKFIKIA
                     EETGSIEKISDWVMNTAAKQIGIWNKKFGLNMKMGINISPNQLDSIKFAHKLEKILEEY
                     DLNSDWIDIEITENIAMKGEATLGKIFSMLSSMGISTSIDDFGTGYSSLSYIQQFSFDR
                     LKIAKELIDNIVTDLSKRHIVKAIVMLAEALNVLTIAEGIETKEQLEVIKEIGCNQVQG
                     YIFSKP"
     aSDomain        complement(817..1308)
                     /aSDomain="TIGR00254"
                     /aSTool="tigrfam"
                     /description="GGDEF: diguanylate cyclase (GGDEF) domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3597_0060"
                     /evalue="4.20E-41"
                     /identifier="TIGR00254"
                     /label="ctg1_3597"
                     /locus_tag="ctg1_3597"
                     /protein_end="505"
                     /protein_start="341"
                     /score="138.4"
                     /tool="antismash"
                     /translation="LEYTSYHDFITNVYNGRYLKKRLDDIIDQKISNQKITIYYIDVDR
                     FKTINDTYGHDIGDSLLIEIAQRLQKETDENSIVARLGGDEFVIVIEGDLSEDEVEKFA
                     QKITTSCNESIYIENYEFNITISIGIASFPTDATSRNVVMKNADMAMYYAKSKGQNKYE
                     I"
     PFAM_domain     complement(826..1296)
                     /aSDomain="GGDEF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00990.23"
                     /description="Diguanylate cyclase, GGDEF domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3597_0250"
                     /evalue="1.20E-42"
                     /label="ctg1_3597"
                     /locus_tag="ctg1_3597"
                     /protein_end="502"
                     /protein_start="345"
                     /score="145.5"
                     /tool="antismash"
                     /translation="SYHDFITNVYNGRYLKKRLDDIIDQKISNQKITIYYIDVDRFKTI
                     NDTYGHDIGDSLLIEIAQRLQKETDENSIVARLGGDEFVIVIEGDLSEDEVEKFAQKIT
                     TSCNESIYIENYEFNITISIGIASFPTDATSRNVVMKNADMAMYYAKSKGQNK"
     CDS             complement(2784..3401)
                     /locus_tag="ctg1_3598"
                     /transl_table=11
                     /translation="MSIGINNSYSSYYTQAYNKTGSNNEKTKVSDDDKTTASSASTIDK
                     TISEEEYFKNICSKYSNINLNMSDSYLKKDNQITVNVSPNLMNKAINSSEMNKKLDNLL
                     QQIPSLPQYINSLNSMLNGNSVNVKSVSIVIDANGEGSCTIELKQNNSKNTSKTSEEEK
                     LRIKRMKERKERNLKLSKEHKIYSDIAVNIDMSFLDRFDTSI"
     PFAM_domain     complement(2853..3254)
                     /aSDomain="DUF6033"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19498.1"
                     /description="Protein of unknown function (DUF6033)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3598_0252"
                     /evalue="9.40E-08"
                     /label="ctg1_3598"
                     /locus_tag="ctg1_3598"
                     /protein_end="183"
                     /protein_start="49"
                     /score="32.3"
                     /tool="antismash"
                     /translation="EEYFKNICSKYSNINLNMSDSYLKKDNQITVNVSPNLMNKAINSS
                     EMNKKLDNLLQQIPSLPQYINSLNSMLNGNSVNVKSVSIVIDANGEGSCTIELKQNNSK
                     NTSKTSEEEKLRIKRMKERKERNLKLSKEH"
     CDS             complement(3458..4069)
                     /locus_tag="ctg1_3599"
                     /transl_table=11
                     /translation="MSIGINNSYSSYYTQASDKTGSNNDKTKVSDADKTTVSSTSTTDK
                     TISKEEYFKNICERYSGANLYMSNSYNMKKNGVTFNFSPQLIEKAIKDSKAAKNLDRLI
                     NLIPSTQQDFNTPKYTLEGRKIDSVSFSVDENGGVSCEIEVEEKNSKNTSKTSDEEKLR
                     IKRMKERKERNLKLSKEHKIYNDIAANIDMSFLDRFDTNI"
     PFAM_domain     complement(3524..3919)
                     /aSDomain="DUF6033"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19498.1"
                     /description="Protein of unknown function (DUF6033)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3599_0253"
                     /evalue="1.30E-05"
                     /label="ctg1_3599"
                     /locus_tag="ctg1_3599"
                     /protein_end="182"
                     /protein_start="50"
                     /score="25.3"
                     /tool="antismash"
                     /translation="EYFKNICERYSGANLYMSNSYNMKKNGVTFNFSPQLIEKAIKDSK
                     AAKNLDRLINLIPSTQQDFNTPKYTLEGRKIDSVSFSVDENGGVSCEIEVEEKNSKNTS
                     KTSDEEKLRIKRMKERKERNLKLSKEHK"
     CDS             complement(4111..4722)
                     /locus_tag="ctg1_3600"
                     /transl_table=11
                     /translation="MPIGINNSYSSYYTQASDKTGSNNDKTKVSNTDKTKASSANTIDK
                     TISKEEYFKNICERYSGANLRMSNSHLNKGNEIISNVSPQLINKAISDPKAAENLNRLL
                     DQMSSIPQYINNHKYTLDGREVKNVSFVIDENGGVSCKCEYVEKDSKNTSKTSDEEKLR
                     IKRMKERKERNLKLSKEHKIYNDIAVNIDMSFLDRFDTNI"
     PFAM_domain     complement(4183..4572)
                     /aSDomain="DUF6033"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19498.1"
                     /description="Protein of unknown function (DUF6033)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3600_0254"
                     /evalue="2.30E-06"
                     /label="ctg1_3600"
                     /locus_tag="ctg1_3600"
                     /protein_end="180"
                     /protein_start="50"
                     /score="27.8"
                     /tool="antismash"
                     /translation="EYFKNICERYSGANLRMSNSHLNKGNEIISNVSPQLINKAISDPK
                     AAENLNRLLDQMSSIPQYINNHKYTLDGREVKNVSFVIDENGGVSCKCEYVEKDSKNTS
                     KTSDEEKLRIKRMKERKERNLKLSKE"
     CDS             complement(4957..6681)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 242.5; E-value:
                     1.5e-73)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_3601"
                     /transl_table=11
                     /translation="MRNKETIYKLINLLKGNGRKVSVIIFFLLISSLISIISPLISKNI
                     MDKGFLSNNKWTVIYYSLLAFALVVIDNVIDFSKEKIRVALKAEITYKLFNKSFCKLRE
                     INLSELNKTNNTELLNNIHSDISNISMIGDGVFFTTITQIFNIIGGIIGLSIISWKLTL
                     LVMCFIPIKFFAINKLTKDRKQMVNDYMLGYSQFASWFGDTLGGIKEIRIFGLFDKKMN
                     EFDDMQNMVIDLEKKMTIQNSFNSVFDNTLQSFITTSLYIIGANMVFNLSLTIGSIVSF
                     IAYVAYCINPISSLFNLGLVLASIFPSAKRYYKFLDMNSEAENNGIIPLNEEMKNRPQI
                     KFENVFFSYDGKSENNILKDINFQINTGDKVAIIGLNGAGKSTIVNLLMRFYKPTGGKI
                     FINEEDVNDINISDYRKNISIVSQDSYLFNDTIKNNICFYKIIEHEKFKQILKDCNLYE
                     FYESLPRDYKIGENGCFLSGGQRQKIFIARALATNNNLIILDEATANVDIDTEMQINEL
                     ISTKLTNKTMIVISHKPSILRYMDKIIVLEDGKVSDIGDHNRLLKESRVYNDILINR"
     PFAM_domain     complement(5170..5610)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3601_0256"
                     /evalue="5.90E-35"
                     /label="ctg1_3601"
                     /locus_tag="ctg1_3601"
                     /protein_end="504"
                     /protein_start="357"
                     /score="120.9"
                     /tool="antismash"
                     /translation="LKDINFQINTGDKVAIIGLNGAGKSTIVNLLMRFYKPTGGKIFIN
                     EEDVNDINISDYRKNISIVSQDSYLFNDTIKNNICFYKIIEHEKFKQILKDCNLYEFYE
                     SLPRDYKIGENGCFLSGGQRQKIFIARALATNNNLIILDEATA"
     PFAM_domain     complement(5809..6615)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3601_0255"
                     /evalue="2.10E-26"
                     /label="ctg1_3601"
                     /locus_tag="ctg1_3601"
                     /protein_end="291"
                     /protein_start="22"
                     /score="93.3"
                     /tool="antismash"
                     /translation="VIIFFLLISSLISIISPLISKNIMDKGFLSNNKWTVIYYSLLAFA
                     LVVIDNVIDFSKEKIRVALKAEITYKLFNKSFCKLREINLSELNKTNNTELLNNIHSDI
                     SNISMIGDGVFFTTITQIFNIIGGIIGLSIISWKLTLLVMCFIPIKFFAINKLTKDRKQ
                     MVNDYMLGYSQFASWFGDTLGGIKEIRIFGLFDKKMNEFDDMQNMVIDLEKKMTIQNSF
                     NSVFDNTLQSFITTSLYIIGANMVFNLSLTIGSIVSFIAYVAYCINP"
     CDS             complement(6905..8371)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 67.9; E-value: 1.6e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3602"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.5e-14, bitscore:
                     51.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEGVKVAILDNGVMDIFYEELKENIYIDEENSINNASIYRNKYS
                     SHGTSCFLILKQFAKSSRISSVEILNEDGKGSIEKLIPAFEWCVENDIKIVNLSFGSIH
                     FKDAEIIQNIINHYASKGIIIIAASSNSGYTSYPSYFSNVIGVANIEDSGIKDDMVRVN
                     NVHTGVDFLAVSQHTIYIEDENIILSKSNSYAAPFVTSQVYNILSHNVNLTLYEVKKTL
                     INQLKKQNEESSLFYCEPNWIENAYIVGGKLKSKARTYFKLFKNCSYEDVKEKIDTLII
                     FNENDLNFYLREKKNIVYLGNDFDLQKCINEKYIWHKSLKEKKIDEEIIIEEDIKIPII
                     IINFSINDDELLILQNLKNLFFYESYNLYAATTNPEGVFYNLEYIPKKYISNVKERNTI
                     KSFLYKDTYYKRSDIIILSYYNNEKKLYESKNAIKYDIGADLVISIEHSNIYKVIFNDN
                     ENEQITKEYENIGTNEIRDIYLQILDTFKT"
     PFAM_domain     complement(7679..8365)
                     /aSDomain="Peptidase_S8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00082.24"
                     /description="Subtilase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3602_0257"
                     /evalue="1.50E-15"
                     /label="ctg1_3602"
                     /locus_tag="ctg1_3602"
                     /protein_end="231"
                     /protein_start="2"
                     /score="57.3"
                     /tool="antismash"
                     /translation="EGVKVAILDNGVMDIFYEELKENIYIDEENSINNASIYRNKYSSH
                     GTSCFLILKQFAKSSRISSVEILNEDGKGSIEKLIPAFEWCVENDIKIVNLSFGSIHFK
                     DAEIIQNIINHYASKGIIIIAASSNSGYTSYPSYFSNVIGVANIEDSGIKDDMVRVNNV
                     HTGVDFLAVSQHTIYIEDENIILSKSNSYAAPFVTSQVYNILSHNVNLTLYEVKKTLIN
                     QLKKQNE"
     CDS             complement(8518..8778)
                     /locus_tag="ctg1_3603"
                     /transl_table=11
                     /translation="MDKKDIECKIKEIFKKKFFLDLDKMRKEEENMSMLDPSIGMMPRD
                     LLTLFFELQECFEIKFEEKDILEKRFDCYSDIVSLIEEKVS"
     CDS             complement(8793..9902)
                     /locus_tag="ctg1_3604"
                     /transl_table=11
                     /translation="MEKKMNAIVFPYDFEFLPVIRNNHLLNNIDIKYLVAPSGFGLENK
                     DAYYFDDSEKLGFTIKSQISEECFENIDVVWITESIQKVEFTNIKDLIENIGKHNKNIL
                     YTVNSGYIYEEEIYKLCEANNVKIITINDYIKDFNMVDCNNVEISFALAKINTPIITVL
                     GMSPMTQKFDLQLYLRDKFLQNGYKVSQIGTKALSETMGFYSIPDWFFSNEYKENEKIL
                     MFNKFVKEIEKSENPDVIIIGVPDCIIPLTKNHSFNYGIYAFEICNAVNSDYTILSLLD
                     GLYNDEFFDEMKLACNYRFNVELDGFFISKYRPVSNSLDQLKLSFTHTNGTKNSSEKYN
                     IFNADDLKRDSIINEVIKKLSMYSVFEVI"
     aSDomain        complement(8820..9887)
                     /aSDomain="TIGR04066"
                     /aSTool="tigrfam"
                     /description="nat_prod_clost: peptide maturation system
                     protein, TIGR04066 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3604_0061"
                     /evalue="8.30E-82"
                     /identifier="TIGR04066"
                     /label="ctg1_3604"
                     /locus_tag="ctg1_3604"
                     /protein_end="361"
                     /protein_start="5"
                     /score="273.0"
                     /tool="antismash"
                     /translation="NAIVFPYDFEFLPVIRNNHLLNNIDIKYLVAPSGFGLENKDAYYF
                     DDSEKLGFTIKSQISEECFENIDVVWITESIQKVEFTNIKDLIENIGKHNKNILYTVNS
                     GYIYEEEIYKLCEANNVKIITINDYIKDFNMVDCNNVEISFALAKINTPIITVLGMSPM
                     TQKFDLQLYLRDKFLQNGYKVSQIGTKALSETMGFYSIPDWFFSNEYKENEKILMFNKF
                     VKEIEKSENPDVIIIGVPDCIIPLTKNHSFNYGIYAFEICNAVNSDYTILSLLDGLYND
                     EFFDEMKLACNYRFNVELDGFFISKYRPVSNSLDQLKLSFTHTNGTKNSSEKYNIFNAD
                     DLKRDSIINEVIKKLS"
     CDS             complement(9906..11351)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3605"
                     /sec_met_domain="PF04055 (E-value: 9.2e-15, bitscore: 53.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.7e-11, bitscore: 42.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.2e-08, bitscore:
                     32.4, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     6.1e-13, bitscore: 47.0, seeds: 13, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKNIPHIHLLKLYNEYYLYDVNTNAIVSIPSKVYEYLQSSLNSD
                     ENSNNLYECLDKNLRDGIEYLKSQGMLLPRNENLKIKHVETDLLKDLYENNLRSLTLQV
                     TQNCNLRCSYCVYSGSYVNRTHSNKRMSWEVAKKAIDFFYEHSTNTEEVVFGFYGGEPL
                     LEFELMKKCINYIRELFIGKKIFFTVTTNATLLTEEKIKFLSENNFDLVISLDGPADVQ
                     NKNRIFADEHRGTFEVVMKNLSKVKMIDESFYKRISFNAVIDLKENFSCANEFFLSYDM
                     VKDLNVAGNYVNVTNKVEKIDINTKYYADAQYETFKAYLYHCSNIFSAYKPTLLNNVVN
                     NIKSSMNDRVKVRGERILQSSPGGQCIPGIQRFFVNVDGEFYPCERVNENADILNIGNI
                     HNGFDIDKAKNILNIANTTEEECRKCWCFKICTQCVSMAEEDGDLSRKRRLSRCSETQK
                     NAEEQIKDYIVLKKYGCDFEKEV"
     aSDomain        complement(9924..11330)
                     /aSDomain="TIGR04068"
                     /aSTool="tigrfam"
                     /description="rSAM_ocin_clost: Cys-rich peptide radical SAM
                     maturase CcpM"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3605_0062"
                     /evalue="2.70E-157"
                     /identifier="TIGR04068"
                     /label="ctg1_3605"
                     /locus_tag="ctg1_3605"
                     /protein_end="476"
                     /protein_start="7"
                     /score="522.3"
                     /tool="antismash"
                     /translation="IHLLKLYNEYYLYDVNTNAIVSIPSKVYEYLQSSLNSDENSNNLY
                     ECLDKNLRDGIEYLKSQGMLLPRNENLKIKHVETDLLKDLYENNLRSLTLQVTQNCNLR
                     CSYCVYSGSYVNRTHSNKRMSWEVAKKAIDFFYEHSTNTEEVVFGFYGGEPLLEFELMK
                     KCINYIRELFIGKKIFFTVTTNATLLTEEKIKFLSENNFDLVISLDGPADVQNKNRIFA
                     DEHRGTFEVVMKNLSKVKMIDESFYKRISFNAVIDLKENFSCANEFFLSYDMVKDLNVA
                     GNYVNVTNKVEKIDINTKYYADAQYETFKAYLYHCSNIFSAYKPTLLNNVVNNIKSSMN
                     DRVKVRGERILQSSPGGQCIPGIQRFFVNVDGEFYPCERVNENADILNIGNIHNGFDID
                     KAKNILNIANTTEEECRKCWCFKICTQCVSMAEEDGDLSRKRRLSRCSETQKNAEEQIK
                     DYIVLKKYGCD"
     aSDomain        complement(10011..10256)
                     /aSDomain="TIGR04085"
                     /aSTool="tigrfam"
                     /description="rSAM_more_4Fe4S: radical SAM additional
                     4Fe4S-binding SPASM domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3605_0063"
                     /evalue="2.20E-08"
                     /identifier="TIGR04085"
                     /label="ctg1_3605"
                     /locus_tag="ctg1_3605"
                     /protein_end="447"
                     /protein_start="365"
                     /score="32.4"
                     /tool="antismash"
                     /translation="CIPGIQRFFVNVDGEFYPCERVNENADILNIGNIHNGFDIDKAKN
                     ILNIANTTEEECRKCWCFKICTQCVSMAEEDGDLSRK"
     PFAM_domain     complement(10686..11039)
                     /aSDomain="Fer4_12"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13353.8"
                     /description="4Fe-4S single cluster domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3605_0258"
                     /evalue="2.00E-10"
                     /label="ctg1_3605"
                     /locus_tag="ctg1_3605"
                     /protein_end="222"
                     /protein_start="104"
                     /score="41.4"
                     /tool="antismash"
                     /translation="TQNCNLRCSYCVYSGSYVNRTHSNKRMSWEVAKKAIDFFYEHSTN
                     TEEVVFGFYGGEPLLEFELMKKCINYIRELFIGKKIFFTVTTNATLLTEEKIKFLSENN
                     FDLVISLDGPADVQ"
     CDS             complement(11549..11767)
                     /locus_tag="ctg1_3606"
                     /transl_table=11
                     /translation="MKKVSLGKKNDFEKGTFMAYACNCNCFNISCGTCTNCSKYKKNDV
                     QGFYALSLVNNSKIEMKSMAPMTMLGA"
     CDS             complement(11808..12440)
                     /locus_tag="ctg1_3607"
                     /transl_table=11
                     /translation="MSIGINSSYGSYYTQASNKTGSNNNDKTKVSDADKTTVSSVSTTD
                     KTISKEEYFKNVCERYSGANLYMSNSYNMKKNELTYNISPKLIEKATKDPKVAQNLERL
                     LNQIPSLKEYIGNHKYTLGGSEVKSVSVVIDENGGLSCTSEIEPKKSKNTSNTKDSSKT
                     SEEEKLRIKRMKERKERNLKLSKEHKIYSDIAANIDMSFLDRFDTNI"
     PFAM_domain     complement(11883..12287)
                     /aSDomain="DUF6033"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19498.1"
                     /description="Protein of unknown function (DUF6033)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3607_0259"
                     /evalue="9.30E-08"
                     /label="ctg1_3607"
                     /locus_tag="ctg1_3607"
                     /protein_end="186"
                     /protein_start="51"
                     /score="32.3"
                     /tool="antismash"
                     /translation="EYFKNVCERYSGANLYMSNSYNMKKNELTYNISPKLIEKATKDPK
                     VAQNLERLLNQIPSLKEYIGNHKYTLGGSEVKSVSVVIDENGGLSCTSEIEPKKSKNTS
                     NTKDSSKTSEEEKLRIKRMKERKERNLKLSK"
     CDS             complement(12502..13131)
                     /locus_tag="ctg1_3608"
                     /transl_table=11
                     /translation="MSIGINSSYSSYYTQASNKTGVNNDKTKVSDADKTTVSSTSTTDK
                     TISKDEYFKNLCERYSGANLHMSSSGIMKKNEITYNISPKLVDKATKDSKYAEKLEGLL
                     SQIQSFKEYFNTHKYTLGGSEVKSVSVVIDENGGVSGMLDIEPKNSKNTSNTKDSSKTS
                     EEEKLRIKRMKEKKERNLKLSKEHKIYSDIAANIDMSFLDRFDTNI"
     PFAM_domain     complement(12574..12984)
                     /aSDomain="DUF6033"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19498.1"
                     /description="Protein of unknown function (DUF6033)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3608_0260"
                     /evalue="2.30E-08"
                     /label="ctg1_3608"
                     /locus_tag="ctg1_3608"
                     /protein_end="186"
                     /protein_start="49"
                     /score="34.3"
                     /tool="antismash"
                     /translation="DEYFKNLCERYSGANLHMSSSGIMKKNEITYNISPKLVDKATKDS
                     KYAEKLEGLLSQIQSFKEYFNTHKYTLGGSEVKSVSVVIDENGGVSGMLDIEPKNSKNT
                     SNTKDSSKTSEEEKLRIKRMKEKKERNLKLSKE"
     CDS             complement(13670..14263)
                     /locus_tag="ctg1_3609"
                     /transl_table=11
                     /translation="MSNHEKNEKIDLRIRRTHKLLSNSLMSLLTEKSFEDIRVSDICDQ
                     AMVHRTTFYKHFEDKYQLLDCLLRDLIEDFEKESLKTPPHDPKQYYSNLFKLLLEHMCK
                     NKKMYTIGLLNNSSAMKQLQKIVLECIEYRLRNDEKNGIKFIVPIDIIAGFFSPALVYS
                     AGEWLEEDMIISIEEMVKYCDTIVEALQIRYKSV"
     PFAM_domain     complement(13703..13987)
                     /aSDomain="TetR_C_8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14278.8"
                     /description="Transcriptional regulator C-terminal region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3609_0262"
                     /evalue="3.00E-08"
                     /label="ctg1_3609"
                     /locus_tag="ctg1_3609"
                     /protein_end="187"
                     /protein_start="92"
                     /score="33.8"
                     /tool="antismash"
                     /translation="NLFKLLLEHMCKNKKMYTIGLLNNSSAMKQLQKIVLECIEYRLRN
                     DEKNGIKFIVPIDIIAGFFSPALVYSAGEWLEEDMIISIEEMVKYCDTIV"
     PFAM_domain     complement(14069..14185)
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3609_0261"
                     /evalue="3.50E-06"
                     /label="ctg1_3609"
                     /locus_tag="ctg1_3609"
                     /protein_end="65"
                     /protein_start="26"
                     /score="26.8"
                     /tool="antismash"
                     /translation="SLLTEKSFEDIRVSDICDQAMVHRTTFYKHFEDKYQLLD"
     CDS             14478..15689
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 162; E-value:
                     3.1e-49)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_3610"
                     /transl_table=11
                     /translation="MHKKILVICLVLFNLSIFSGCSAKTNPSTEVKTYPVKTIELQDKN
                     YPVSLEYEGITGGSEVRKLSFKSSSKISKIFVSKGQHIKNGDSLIDLDKTDLNSATEAS
                     KAQMAAASAQYNKALNGAQSEDINKAQIAVKNAQANYNYYKDLYDKNVTLYEAHAIPQQ
                     EVNDTKVKLDGSENDLNSAQETLKQLQNGTREEDKQAALAQLNSAKVDYDSKVNLTQDA
                     SLKADEDGYVVDILCKEGEIQASGNPVILIRSENQVVTVGLSDTDVKKIQLGTKAQVKI
                     DDVTTDGEVMNVVQMADKQSGTYSAEIKLLNQIDNSKFYIGQCAKVYINEGEKNGIWIP
                     IASILNDGQDYVYVVEDGRAVRKNITLGQTNENQVCVDGLKNGDNLVNEGMKNIKAGYQ
                     VSVE"
     PFAM_domain     14655..14798
                     /aSDomain="Biotin_lipoyl_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13533.8"
                     /description="Biotin-lipoyl like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3610_0263"
                     /evalue="3.20E-06"
                     /label="ctg1_3610"
                     /locus_tag="ctg1_3610"
                     /protein_end="107"
                     /protein_start="59"
                     /score="26.9"
                     /tool="antismash"
                     /translation="EVRKLSFKSSSKISKIFVSKGQHIKNGDSLIDLDKTDLNSATEAS
                     KAQ"
     PFAM_domain     15147..15416
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3610_0264"
                     /evalue="6.30E-07"
                     /label="ctg1_3610"
                     /locus_tag="ctg1_3610"
                     /protein_end="313"
                     /protein_start="223"
                     /score="30.1"
                     /tool="antismash"
                     /translation="LKADEDGYVVDILCKEGEIQASGNPVILIRSENQVVTVGLSDTDV
                     KKIQLGTKAQVKIDDVTTDGEVMNVVQMADKQSGTYSAEIKLLNQ"
     CDS             15703..18786
                     /gene_functions="transport (smcogs)
                     SMCOG1049:AcrB/AcrD/AcrF family protein (Score: 815.8;
                     E-value: 8.4e-247)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_3611"
                     /transl_table=11
                     /translation="MGLINAAIKNKKIVMFLVLLSIISGFICYYYIPKQESPDVSSPAA
                     MITTIYPGASPKDVESLVTKKIEDKIEEIDGYDYAESYSQNSASIVIVYLNNDADKDKA
                     WRSLRDKIKDLKAELPDGCEDSKIDTNLTQTAGMILSITGESYSYEQLGNYADDIKKQL
                     SNVSGISRFDIKGKQDKQVKVKVDLSKINKYSISLEDVCGVLQSQNVEIPSGSLELATG
                     KIKVQTPGSFTSLKDIENTIVGVSTETGQTIKLKDIASINMDYDDDSNYKYTDNGENAV
                     LLAGYFQDNKNIVLIGDDVRKKLDEIKKQLPQDLNIEEVTFQPKDVNESVSFFMENLRD
                     GVILVVITVLIGMGIRNALVVSSVIPISIAMSFIAMELLGIKVHQISTTALIIALGILV
                     DDAIVIGDVVQVGIDEGLPGDEAAFKGIKKLFVPVFTSTLIIVGAFAPLLSIPGAVGEF
                     IRTLPQVVMICITCSYISALLITPAMSSLFFKKSKKAEKENKIQKLLSKLLTYGLNHKI
                     KIIAASLLIFSVSMGLMNLLSSQFFPYVDKNIIYINVSNEKVEDLDSTNNLVKEVENVL
                     KSQEEVTNYTSAIGGGLPSFYVTLPTVTPSKDTAQIMVKVDLDKTKKFDTREKLVEHIQ
                     SELDNKISGGTATVKLLEQADPIGALVRMRLTGDDLDKIYTASEQIQENLKNIPGTTNV
                     RDDAAKKTYEYEVNIDSTKASQYGLLKSDILKQMNIALKGYSSSVYRKSGSEYDILVKS
                     NIASVEDLKNLQVKSSVTNNKILLSQVASINLNSELDQIKHYKKDKTVTVYSDLKSGYN
                     SSDIENTVKTEINKMDLNGVNVLYDGEQKQIENNFSNLAIAGVLIIVIIYLILFVQFKS
                     FIQPIVILYSLPLSLIGVIVGLLMCDMPLSLTAVMGIISLIGVVIRNAILLVEYIIEGR
                     HEGLSIDEACVHAVSQRFRPIILSSTATITGLIPLAFSKSALFGPMSVTIIFGLASATF
                     LTFIVVPVMYSLVNTQLEKKRQHNFLQILKNVLHKYKK"
     PFAM_domain     15712..18708
                     /aSDomain="ACR_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00873.21"
                     /description="AcrB/AcrD/AcrF family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3611_0265"
                     /evalue="3.80E-185"
                     /label="ctg1_3611"
                     /locus_tag="ctg1_3611"
                     /protein_end="1002"
                     /protein_start="3"
                     /score="617.6"
                     /tool="antismash"
                     /translation="INAAIKNKKIVMFLVLLSIISGFICYYYIPKQESPDVSSPAAMIT
                     TIYPGASPKDVESLVTKKIEDKIEEIDGYDYAESYSQNSASIVIVYLNNDADKDKAWRS
                     LRDKIKDLKAELPDGCEDSKIDTNLTQTAGMILSITGESYSYEQLGNYADDIKKQLSNV
                     SGISRFDIKGKQDKQVKVKVDLSKINKYSISLEDVCGVLQSQNVEIPSGSLELATGKIK
                     VQTPGSFTSLKDIENTIVGVSTETGQTIKLKDIASINMDYDDDSNYKYTDNGENAVLLA
                     GYFQDNKNIVLIGDDVRKKLDEIKKQLPQDLNIEEVTFQPKDVNESVSFFMENLRDGVI
                     LVVITVLIGMGIRNALVVSSVIPISIAMSFIAMELLGIKVHQISTTALIIALGILVDDA
                     IVIGDVVQVGIDEGLPGDEAAFKGIKKLFVPVFTSTLIIVGAFAPLLSIPGAVGEFIRT
                     LPQVVMICITCSYISALLITPAMSSLFFKKSKKAEKENKIQKLLSKLLTYGLNHKIKII
                     AASLLIFSVSMGLMNLLSSQFFPYVDKNIIYINVSNEKVEDLDSTNNLVKEVENVLKSQ
                     EEVTNYTSAIGGGLPSFYVTLPTVTPSKDTAQIMVKVDLDKTKKFDTREKLVEHIQSEL
                     DNKISGGTATVKLLEQADPIGALVRMRLTGDDLDKIYTASEQIQENLKNIPGTTNVRDD
                     AAKKTYEYEVNIDSTKASQYGLLKSDILKQMNIALKGYSSSVYRKSGSEYDILVKSNIA
                     SVEDLKNLQVKSSVTNNKILLSQVASINLNSELDQIKHYKKDKTVTVYSDLKSGYNSSD
                     IENTVKTEINKMDLNGVNVLYDGEQKQIENNFSNLAIAGVLIIVIIYLILFVQFKSFIQ
                     PIVILYSLPLSLIGVIVGLLMCDMPLSLTAVMGIISLIGVVIRNAILLVEYIIEGRHEG
                     LSIDEACVHAVSQRFRPIILSSTATITGLIPLAFSKSALFGPMSVTIIFGLASATFLTF
                     IVVPVMYSLV"
     CDS             complement(19248..20669)
                     /locus_tag="ctg1_3612"
                     /transl_table=11
                     /translation="MGEKEEKKLGRLKRAKNKQSKMMKKTIASIGCLAAIYLGIALYST
                     THFNFGTKIDGVNVGGKSVTKAEDILSSEIQSYKLELDERGDSKEEIKGTDIGLKYDSD
                     KIKQLKDNQSSLGWIATLFKKDDTDDSQIYSYDEDLLNKALSNLSCVNKKKVTRPQNAS
                     FEYKDGSYQIVDEVLGDKINIDALHDNVADAILNGEESIDLGTDNSYENPQYTSKSEEV
                     QNAKDTLNKYASLKITYDSHGTKEVLDGSTINTWLGVNDNMEVTFDENKVKSYVDKIAG
                     IYNTFGSTRSFVTSSKTTVQVDGGNYGWIVNKSKEVKDLIEAVKGGQDVTKEPAYSQTA
                     VSKDSNDIGDTYVEVNLTKQHVWFYKKGALVVEGDVVTGNVSNNTGTPAGTYVLNYKEK
                     NATLKGENYSSPVDYWMPFNGNIGIHDASWRNGVFGGTIYKTSGSHGCVNSPYYLAKTI
                     FENIEPGTPIVCYQE"
     PFAM_domain     complement(19263..19619)
                     /aSDomain="YkuD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03734.16"
                     /description="L,D-transpeptidase catalytic domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3612_0268"
                     /evalue="1.30E-17"
                     /label="ctg1_3612"
                     /locus_tag="ctg1_3612"
                     /protein_end="469"
                     /protein_start="350"
                     /score="64.7"
                     /tool="antismash"
                     /translation="TYVEVNLTKQHVWFYKKGALVVEGDVVTGNVSNNTGTPAGTYVLN
                     YKEKNATLKGENYSSPVDYWMPFNGNIGIHDASWRNGVFGGTIYKTSGSHGCVNSPYYL
                     AKTIFENIEPGTPIV"
     PFAM_domain     complement(19683..20027)
                     /aSDomain="PG_binding_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12229.10"
                     /description="Putative peptidoglycan binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3612_0267"
                     /evalue="3.70E-15"
                     /label="ctg1_3612"
                     /locus_tag="ctg1_3612"
                     /protein_end="329"
                     /protein_start="214"
                     /score="56.3"
                     /tool="antismash"
                     /translation="YTSKSEEVQNAKDTLNKYASLKITYDSHGTKEVLDGSTINTWLGV
                     NDNMEVTFDENKVKSYVDKIAGIYNTFGSTRSFVTSSKTTVQVDGGNYGWIVNKSKEVK
                     DLIEAVKGGQD"
     PFAM_domain     complement(20064..20384)
                     /aSDomain="PG_binding_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12229.10"
                     /description="Putative peptidoglycan binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3612_0266"
                     /evalue="2.20E-08"
                     /label="ctg1_3612"
                     /locus_tag="ctg1_3612"
                     /protein_end="202"
                     /protein_start="95"
                     /score="34.5"
                     /tool="antismash"
                     /translation="DIGLKYDSDKIKQLKDNQSSLGWIATLFKKDDTDDSQIYSYDEDL
                     LNKALSNLSCVNKKKVTRPQNASFEYKDGSYQIVDEVLGDKINIDALHDNVADAILNGE
                     ESI"
ORIGIN
        1 tcattgaatt tccacttttt caacagccaa aaagttttct tcaaacatat ctgctgtaag
       61 aggcttgcta aatatataac cttgaacttg attgcatccg atctctttta tcacttcaag
      121 ttgctctttt gtttcaatgc cttctgcgat tgttaaaaca tttaatgcct cagctaacat
      181 tactatagcc tttacaatat gtctcttact taagtctgtt actatattat caattaactc
      241 ttttgcaatt tttaaacggt caaaagaaaa ctgctgaata taacttaatg aagaatatcc
      301 tgttccaaaa tcatctattg aagttgatat tcccatactg ctaagcattg aaaatatttt
      361 ccctaaagtc gcttcaccct tcattgcaat attttctgta atctctatat caatccaatc
      421 tgaattcaaa tcatactctt ctaaaatttt ttctaattta tgtgcaaact ttatgctgtc
      481 aagttgatta ggtgaaatat taattcccat tttcatattt aatccaaact ttttattcca
      541 tattcctatt tgctttgcag cagtattcat aacccaatca cttatttttt ctatacttcc
      601 agtttcttca gcaatcttta tgaatttatt aggtgaaata tttcctttta taggtgagtt
      661 ccatcttatt agtgcttcca ttccaactaa ttcattagta tttatatcaa tttgtggttg
      721 ataataaagt tgaaattcat tattataatc tgcattttta agcaataatt caatctcatt
      781 tttttctaaa attaaattac ttatattaga attaaaaatt tcatatttat tttgtccttt
      841 tgattttgca taatacattg ccatatctgc atttttcata acaacatttc tagatgttgc
      901 atcagtcgga aatgatgcaa ttcctatgct tatagttata ttaaactcat aattctctat
      961 ataaatactt tcattgcaac ttgtagttat cttttgagca aatttttcaa cttcatcctc
     1021 actcaaatct ccttcaatta caattacaaa ttcatctcca cctaatcttg ctacaatact
     1081 attttcatca gtttcttttt gtaatctttg agcgatttca atcaataaag aatcaccaat
     1141 atcatgtcca taagtatcat ttattgtttt aaaacgatcc acgtctatat aatatattgt
     1201 tattttctga ttagatattt tttgatctat aatatcatcc aatctttttt ttaaatatct
     1261 gccattataa acatttgtga taaaatcatg ataagatgta tattccaagt cgtcattttt
     1321 gagcaaaagt tcttttgtac gttccttaat tttttcctct aatattaaat ttatattttt
     1381 ctcatcatta agaagtttct cgttatttat agccttctgc acataattac ttgctatttc
     1441 ataaattgta aaaattaaaa ataatattaa tattttatca aaatcaaatc ctttaaatat
     1501 tatatagata ggaatagtta ataataaaat caaacttttt ttagtatttc caatattttt
     1561 agtttgagaa taaaattcat atgcccattt acaattatta tattgtaaaa cacttatccc
     1621 gccaaaggca ataattaaaa acgataatag atatatagta tctggtatcg aattaggaac
     1681 atataaatga taaaaatact catatgtaca aactaaatca ttagcagcat atattgttgc
     1741 ccctaacaat gtaatataca ttcccttagt tacttttcct ctacgtacag aaaaaaacca
     1801 tattataacc caattaataa ttataaaatc tgtaataaca tatataaatg acaaaatatt
     1861 atttacatct tttataaaca aaaaaatatt ctctttcaaa aacaaaaacc aaaacatcac
     1921 aagacaactt gtcgatatta caaaaatatc aagaagaagc tgaactgcat ttgctccttt
     1981 aataaacttt ttcatatata taagtcctga tgtcattata catatattag gaaataaata
     2041 taataaagta aatatagtca tattatctgg attaattccc attagtattt cgcaaattgc
     2101 ccatattata tcagagaatg tccaaattaa cgctgctatt gatggcataa gccaaacgtt
     2161 cttcatacgt tctgattttt tatatacgtg taataatata ataaatgatg ataaagttcc
     2221 tagaggcgat aaaatatccc cccacaaatt agatttaaaa attgctgcaa taaaatatag
     2281 caaaaaacaa attaccccaa aaacaaaaga ccactttaca tacttatcca ttattcccct
     2341 cacctataca aaactttata aaaaatacta tttataatta attatatcaa aatataatct
     2401 cttgtgaata tattggatat acttttccca tataaagtcc attttttaat aaattaatca
     2461 actttaccaa atactttccc ttacctttta cataatatta cacctcattt ttatgagaat
     2521 ttaatatatc acaaacaatg aaattggata catatttatg caatatgcat attgcataaa
     2581 tatgtatcca atttcattag tgattatatt atgatattct ttagcagtaa tcatgtatca
     2641 ataattatca caacttacat aaacttaatt tgaatcttac tgttatttac aagggataat
     2701 gcagccattc cctgaacatc atttttttac ccaaactaaa tttttaatat atcctcccct
     2761 caatattaaa agttcaaaaa tatttatatg ctcgtatcga atctatccaa gaagctcata
     2821 tcaatgttta cggcaatatc actatatatt ttatgttctt tgcttaattt taaattccgt
     2881 tcttttctct ctttcattct ttttatgcgt aacttttcct cttcactcgt tttactggta
     2941 tttttagagt tattttgttt aagttcaatc gtacagctac cttcaccatt tgcatctatt
     3001 acaatactta cactttttac attcacgctg ttaccattta acatagagtt aagtgaattt
     3061 atatattgtg gcagtgacgg aatttgttgt aataaattat ctaatttttt attcatctca
     3121 gaactattaa ttgctttatt cattaaatta ggagaaacat taactgttat ttgattatct
     3181 ttctttaaat atgaatcact catatttaaa tttatattag aatatttact acaaatattt
     3241 ttaaaatact cctcttccga aattgtttta tctattgtgc ttgcactact agctgtagtt
     3301 ttatcatcat cactaacttt agttttctca ttattacttc cagttttatt atatgcttgt
     3361 gtataatacg aactataact attattaatt cctattgaca tattattatt ccccctcatt
     3421 tttttaattc acagaattat acaatatatt ttaaatacta tatatttgta tcaaacctat
     3481 ccaaaaagct catatcaata tttgcagcaa tatcattata tattttatgt tctttgctta
     3541 attttaaatt tcgttctttt ctctctttca ttctttttat gcgtaatttt tcctcatcac
     3601 ttgttttact cgtatttttg gagtttttct cctcaacctc aatttcgcaa cttaccccac
     3661 cattttcatc tactgaaaaa ctaacagaat ctatttttct tccttccaaa gtgtatttag
     3721 gcgtattaaa atcttgttgt gttgatggta ttaaatttat taatctatct agattctttg
     3781 ccgccttaga atctttaatc gctttttcta ttaattgagg cgagaaatta aatgttactc
     3841 cgttcttctt catattatat gaattactca tataaagatt agcacctgaa tatctttcac
     3901 aaatattttt aaaatactcc tctttcgaaa ttgttttatc tgttgtgctt gtactactaa
     3961 ctgtagtttt atcagcatca ctaactttag ttttatcatt attacttcca gttttatcag
     4021 atgcttgtgt ataatacgaa ctgtaactat tattaattcc tattgacata ttattattca
     4081 ctcctcattt ttttaattca cagaattata ctatatattt gtatcgaacc tatccaaaaa
     4141 gctcatatca atatttacag caatatcatt atatatttta tgttctttgc ttaattttaa
     4201 atttcgttct tttctctctt tcattctttt tattcgcaat ttttcctcat cacttgtttt
     4261 actcgtattt ttagaatctt tttctacgta ttcacactta caactaactc caccattttc
     4321 atctattaca aaacttacat tctttacttc tctgccatct aaagtatatt tatgattatt
     4381 aatatattgt ggtattgatg acatttgatc taacaatcta tttaaatttt cagctgcttt
     4441 aggatcacta attgctttgt ttattaattg aggagaaacg ttggaaatta tttcatttcc
     4501 tttattcaaa tgcgaattac tcatacgaag attagcacct gaatatcttt cacaaatatt
     4561 tttaaaatac tcctctttcg aaattgtttt atctattgtg tttgcactac tagctttagt
     4621 tttatcagtg ttactaactt tagttttatc attattactt ccagttttat cagatgcttg
     4681 tgtataatac gaactataac tattattaat tcctattggc atttcattat tcatcccctt
     4741 ataaatttta aaacttaatt acattaaaaa taattcttta tctgatttaa ttaaacatta
     4801 ttttacaaaa gatgtaaata tatcttgcac aaaatgtata acatatgtat accattctcg
     4861 gaaaagcata gatattcttg caatagcgac tatctatgtc ctgatttcgg ctaggataca
     4921 cataagttcg attctcattg cgtaacccta tataaattag cgattaatca atatatcatt
     4981 atatactctg ctttctttca ataatctatt atgatctcct atatcactga ctttcccatc
     5041 ttccaataca atgattttat ccatatatct taatatactt ggtttatggc taataactat
     5101 cattgtttta tttgtaagtt ttgtggatat caattcatta atctgcattt ctgtatcaat
     5161 atctacatta gctgttgctt catctaatat tattaaatta ttattagttg ctaatgctct
     5221 agcaataaaa attttctgtc tttgtccacc tgataagaaa catccatttt cgcctatttt
     5281 ataatccctt ggaagactct cataaaattc atataagtta caatccttta aaatttgttt
     5341 gaatttttca tgttcaataa ttttatagaa acatatatta ttttttatag tatcattaaa
     5401 taaataacta tcctgagaaa caattgatat attttttcta taatcactaa tatttatatc
     5461 attaacatct tcttcattaa taaatatttt tccaccagtt ggtttataaa acctcataag
     5521 caaattaact attgttgatt ttccggcccc atttaaacca attatcgcca ctttatctcc
     5581 tgtattaatt tgaaaattaa tatcttttaa tatattattt tcacttttac catcataaga
     5641 gaaaaacaca ttttcaaatt taatttgtgg tctatttttc atttcttcat ttaaagggat
     5701 gataccatta ttttcagctt ctgaattcat atctaaaaac ttataatatc ttttagcaga
     5761 tggaaatata ctagctaata ctagtcccaa gttaaataat gatgatatag gatttatgca
     5821 atatgcaaca taggcgataa atgaaactat gcttcctata gttaaactta aattaaacac
     5881 catattagcc ccaattatat ataatgaagt agtaataaaa gattgtaatg tattatcaaa
     5941 tactgaatta aacgaattct gaatagtcat tttcttttcc aaatcaataa ccatattttg
     6001 catatcatca aattcattca tctttttatc aaacaaacca aatattctta tttcttttat
     6061 gcctcccaaa gtatctccaa accaactcgc aaattgggaa tatcctaaca tataatcatt
     6121 taccatttgt tttctatctt ttgttaactt atttattgca aaaaatttta taggaataaa
     6181 gcacataact agcaaagtta acttccagct tattatactt aacccaataa ttccacctat
     6241 tatattaaat atttgtgtta tagtagtaaa gaacactcca tctcctatca ttgatatgtt
     6301 tgaaatgtca ctatgtatat tattcaaaag ttccgtatta tttgttttat taagttctga
     6361 aagatttatt tctcttaatt tacaaaaaga tttattaaaa agtttatatg taatttctgc
     6421 ttttaatgct actctaattt tttccttact aaaatctatt acattatcaa taacaactaa
     6481 agcaaaagcc aaaagagaat aatatattac tgtccacttg ttgttactta agaaaccctt
     6541 gtccataata tttttgctta ttaatggtga tataatagat attaatgaag atatgagtaa
     6601 aaaaaagata atcacagaaa cttttctgcc attacctttt aataagttaa ttaatttata
     6661 tattgtttct ttattacgca tgtttctatt ctcctttaac tacatttaag gcacttgaaa
     6721 gaaaataaca gttgcaaaaa tgccatgatt atttttaaat tagtagtata gtcagcctat
     6781 taggacaata tgctgatgtg atatgagaat gcaaatctat gatttgatgt aaatcgctta
     6841 cactcagcaa gcgcattcaa ttctagcttc atatgattga aactacgctt ggcagaggga
     6901 ctttttatgt tttaaatgtg tctaatattt gtaaatatat atctctaatt tcattagtgc
     6961 ctatattctc atattcttta gtaatctgct cattttcatt atcattaaaa atcactttat
     7021 agatattaga atgctctata gatattacaa gatctgcacc tatatcatat ttgattgcat
     7081 ttttactttc atatagtttt ttttcattat tgtaataact taaaattata atatcacttc
     7141 ttttgtaata tgtatcttta tacagaaatg acttaattgt atttctttcc ttaacattgc
     7201 ttatatattt tttcggtata tattctaaat tataaaaaac accttctgga ttcgtagttg
     7261 ccgcatataa attataagat tcataaaaaa ataaattctt taaattttgt aatattagta
     7321 attcatcatc atttatagaa aagttaatta taattatagg tatttttata tcttcttcaa
     7381 ttataatttc ctcatctatc tttttctctt ttagagattt atgccatata tatttttcat
     7441 ttatacattt ttgtaaatca aaatcatttc ccaaatatac aatattcttt ttttctctta
     7501 aataaaaatt caaatcattt tcattaaata taataagagt atctattttt tcttttacat
     7561 cttcataact acaattctta aacaacttaa aatacgttct agctttactt ttgagttttc
     7621 ctcctacgat atacgcattt tcaatccaat ttggttcaca ataaaaaaga ctactttcct
     7681 cattttgctt tttcaattga tttattaatg ttttttttac ttcatacaat gtcaaattaa
     7741 cgttatgact taaaatgttg taaacctgtg aagtaacaaa tggtgcagca taactgttgc
     7801 ttttagataa tataatattt tcatcttcta tatatattgt gtgctgtgaa actgctaaaa
     7861 agtccactcc tgtatgaaca ttattaactc ttaccatatc atcctttatc ccactatcct
     7921 caatattggc tactccaata acatttgaaa aatatgaagg atatgaggta tatccactat
     7981 tagagctagc tgcaataatt attattcctt tgctggcata atgatttata atattttgta
     8041 ttatctcagc atctttaaaa tggatacttc caaaacttaa attcacaatt tttatatcat
     8101 tttcaacgca ccattcaaaa gctggaatca acttttctat actgccctta ccatcctcat
     8161 tcaaaatttc cacactacta attctactac tctttgcaaa ctgttttaat attaaaaaac
     8221 agcttgttcc atgtgaagaa tatttatttc tatagatact tgcattattt atgctatttt
     8281 cttcatcaat ataaatattt tctttcaatt cttcataaaa aatatccata acaccattat
     8341 ctaatatagc aacctttacc ccttcttcca tcctactccc cctaacaata aaattatgat
     8401 ttatttttta actaaagtaa taattttatt tgtaaatgca tgtgcataaa ctacatcgtt
     8461 aatgtttata tattcattta tcgttccact atatttatta agtacattaa tatagcatta
     8521 gctaactttt tcttcaatca gactaacaat atcactatag caatcaaatc ttttttctag
     8581 tatatctttt tcttcaaact ttatttcaaa acactcttgt aactcaaaaa ataaagttaa
     8641 taaatctctt ggcatcatcc caatactcgg atctaacata ctcatatttt cttcttcttt
     8701 tctcatctta tctaaatcaa gaaaaaattt ctttttaaat atttctttaa ttttacactc
     8761 tatatctttc ttatccataa tgtcctccat tcttaaatta cttcaaatac agaatacata
     8821 gacaactttt ttataacttc atttataata gaatctcttt ttaaatcatc agcattaaaa
     8881 atattatatt tttcgctact attctttgtc ccatttgtat gtgtaaaact aagcttaagt
     8941 tgatctaatg aattagatac tggtctatac ttagatataa agaaaccatc caattccaca
     9001 ttaaacctat aattacatgc taacttcatt tcatcaaaaa attcatcatt atataaacca
     9061 tctaataatg acagaatagt ataatctgaa ttaacggcat tacatatctc aaaagcataa
     9121 ataccataat taaaactatg attcttagtt aatggaataa tacaatcagg cactccaata
     9181 attatcacat caggattttc acttttttca atttccttaa caaacttgtt aaacattaaa
     9241 atcttttcgt tttctttata ttcattacta aaaaaccaat ctggtataga gtaaaatccc
     9301 atggtttcac ttaatgcttt tgttcctatt tgactgactt tatagccatt ttgtaaaaat
     9361 ttatccctta aatataattg aagatcaaat ttttgtgtca taggagacat tcctaaaaca
     9421 gtaattatag gtgtatttat tttcgctaat gcaaatgaaa tctctacatt attacaatcc
     9481 accatattaa aatctttaat ataatcatta attgtaatta tttttacatt gttagcttcg
     9541 cataatttat atatttcttc ttcatagata taccctgagt taaccgtata aagaatattt
     9601 ttattatgtt taccaatgtt ctcaattaaa tcttttatat tggtaaattc caccttttgt
     9661 attgattcag taatccatac aacatctata ttctcaaagc attcttctga aatttgactt
     9721 ttaatagtaa accctaattt ttcactatca tcaaaataat atgcatcctt attttctaat
     9781 ccaaatccgc ttggggcaac taaatactta atgtcaatat tgtttaataa atgattattt
     9841 cttatcactg gtaaaaactc aaaatcatac ggaaatacta tagcattcat ttttttctcc
     9901 attccttata cctccttttc aaaatcacaa ccatatttct ttaaaacaat ataatctttt
     9961 atttgctctt ctgcattttt ttgtgtttca ctacatctac tcaatcttct ttttcttgat
    10021 agatctccat cctcttctgc catagataca cattgggtac atatcttaaa gcaccaacat
    10081 ttcctacatt cttcttcagt agtattagct atatttaaaa tgttctttgc tttgtcaata
    10141 tcaaagccat tatgtatatt accaatattt aaaatatcag cattttcatt tactctctca
    10201 caaggataaa actcaccatc cacattcaca aaaaatcttt gtattcctgg aatgcattgt
    10261 cctcctggac tagattgtaa aattctttca cctcttacct taactctatc attcatgctg
    10321 ctttttatat tattaacaac attatttaat aaagtaggct tgtacgcact aaatatgtta
    10381 ctgcaatgat ataaatatgc cttaaatgtt tcatattgtg catccgcata gtatttagtg
    10441 tttatatcta tcttctcaac cttatttgta acattcacat agttaccagc tacatttaaa
    10501 tcttttacca tatcatatga aaggaaaaat tcatttgcac aagaaaaatt ttcttttaag
    10561 tctataaccg cattaaaaga tatcctttta taaaaacttt catcaatcat tttaactttg
    10621 cttaaatttt tcataacaac ttcaaaagta cctctatgtt catctgcaaa aattctattt
    10681 ttattctgca catctgctgg accatctaaa ctaattacta aatcaaaatt attttctgac
    10741 aaaaatttta tcttttcctc tgtaagtagt gttgcatttg ttgtcacagt gaagaaaatc
    10801 ttctttccaa taaaaagttc tcttatataa ttaatacatt tcttcattaa ttcaaattct
    10861 agcaaaggtt ctccaccata aaatccaaaa acaacttctt cagtattagt tgaatgttca
    10921 taaaagaaat caatcgcttt tttagctact tcccacgaca ttctcttatt actatgtgtt
    10981 ctattaacat aacttccaga ataaacgcaa taactacatc ttaaattaca gttttgtgtt
    11041 acctgtaaag ttagtgatct taaattattt tcatataaat cttttaataa atcagtttct
    11101 acatgcttta tctttagatt ttcatttcgt ggtaataaca ttccttgaga ctttagatat
    11161 tctataccat ctcttaaatt cttatctaag cattcatata ggttattact attttcatcg
    11221 ctgtttaaac tagattgtaa atattcataa acctttgaag gtatagatac aatagcattt
    11281 gtatttacat catacaaata gtattcatta tacagtttta ataaatgaat atgtggaata
    11341 ttttttagca tctgttcaat tccttcctaa tttattatca aaaatttatc aagctccatt
    11401 ctcaaattta atttattgaa tggagctttt aaataagcaa ataaaatata ataacattta
    11461 atttgctatt agaatatatt aaaaataata tacaaattat tcaaataata atttattata
    11521 gcttattttt aatatgcttt agtagtaatt atgcacctaa catagtcata ggagccatag
    11581 atttcatttc tattttgctg ttattcacaa gacttagtgc ataaaatcct tgaacatcat
    11641 tttttttgta cttgctgcag ttagtgcatg tcccacatga aatattgaaa caattacaat
    11701 tacatgcata agccataaaa gttccctttt caaaatcatt ttttttacct aaactcactt
    11761 ttttcatata tttcacctcc cttcaatatt aaaattcaaa aaaatattta tatatttgta
    11821 tcgaatctat ccaagaagct catatcaatg tttgcagcaa tatcactata tattttatgt
    11881 tctttgctta attttaaatt ccgttctttt ctttctttca ttctttttat tcgtaatttt
    11941 tcctcttcac tcgttttact tgaatccttt gtattacttg tatttttaga tttctttggt
    12001 tcaatctcac tcgtgcaact taatccacca ttttcatcta ttacaacgct tacacttttt
    12061 acctcacttc cccctaaagt atatttatga ttaccaatat actccttcaa tgatggtatt
    12121 tgatttaata atcgttccaa attttgagcc accttaggat ctttagttgc cttctctatc
    12181 aatttaggag aaatattata agtcaattca ttctttttca tattatatga attgctcata
    12241 taaagattag cacctgaata tctttcacaa acatttttaa aatactcctc tttcgaaatt
    12301 gttttatctg ttgtgcttac actactaact gtagttttat cagcatcact aactttagtt
    12361 ttatcattat tattacttcc agttttatta gatgcttgtg tataatacga accataacta
    12421 ctattaattc ctattgacat attattattc accccttaat tttcttaata tgcaaaatta
    12481 tacaatatat tttttaaaat actatatatt tgtatcgaat ctatccaaga agctcatatc
    12541 aatgtttgca gcaatatcac tatatatttt atgttctttg cttaatttta aatttcgctc
    12601 ttttttctct ttcattcttt ttattcgtaa tttttcctct tcactcgttt tacttgaatc
    12661 ctttgtatta cttgtatttt tagaattctt aggttcaata tcaagcatac cgctgactcc
    12721 accattttca tctattacaa cgcttacact ttttacctca cttcctccta aagtgtattt
    12781 atgagtattg aaatattcct taaatgattg tatttgactt aacaatcctt ctaacttttc
    12841 agcatattta gagtcctttg tcgccttatc tactaattta ggcgagatat tataggttat
    12901 ttcattcttt ttcataatac ctgagctact catatgaaga ttagcacctg aatatctttc
    12961 acaaagattt ttaaaatact catctttcga aattgtttta tctgttgtgc ttgtactact
    13021 aactgtagtt ttatcagcat cactaacttt agttttatca ttattaactc cagttttatt
    13081 agatgcttgt gtataatacg aactataact actattaatt cctattgaca tttcattatt
    13141 catcccctta tgaattttaa agcttaatta catgaaaaat attcctttat ttgatttaat
    13201 taaacattat tttacaaaga atgtaaatat atattacaca aaacgtataa tatatggaac
    13261 aaaaggtaaa taaattgcac ctaattactg acaacctttc aatgaaaatt ttataaatct
    13321 gtgcaacaaa aatatgtgaa attcaattaa ctatcgcgtt tggatatcta tatataaaat
    13381 tagccttaac cattattata attggttaag gctaattttc tctccaatag aaagaatctc
    13441 attttttatt tatcaagaca atatcatcat tagtttgaac tatacataag ttctaaaaaa
    13501 tattgttcat caaacatgaa tttctacttt tataaatatt caattagtac tcttactaat
    13561 tgtgaatttt attaattaga acttatatat aaagaaaaaa cgtgtatctt catacacatt
    13621 aggcttttta tttaaaaagt gttgattctt tgcttaataa aaacaacagc tatacacttt
    13681 tatatctaat ctgtaatgct tcaactatag tatcacaata ttttaccatt tcttcgattg
    13741 aaataatcat atcttcttca agccactctc ctgctgaata taccaatgct ggagaaaaaa
    13801 agcctgcaat aatatcaatt ggcactataa atttaattcc atttttttcg tcatttctta
    13861 gtcgatattc tatacattca agtactatct tttggagctg cttcattgct gaactattat
    13921 ttaataatcc tattgtgtac atctttttat ttttgcacat atgctcaaga agaagtttaa
    13981 ataaattgct ataatattgc tttgggtcat gtggtggagt ttttaaactt tctttttcaa
    14041 aatcttctat caaatctctt aataaacaat caagtaattg atatttatct tcaaaatgct
    14101 tgtaaaatgt agttctatgt accattgctt ggtcacaaat atctgaaact ctaatatctt
    14161 caaaactttt ttctgtaagc aaagacatta atgaattaga taataattta tgagttcttc
    14221 gtattcttaa atcaattttt tcattcttct catgattact catgtttttc ctcctaatca
    14281 aacaatcaac aaaaattcta atgtgtagaa taactatata attttaaatt tttgtttctt
    14341 gataacaata tagcaatagt ataaattata catatacaat tgtaaagtta ttcatacata
    14401 tgtagattat atactatttt aaacttaaga gtctaaatag atcttttatt ctggattctt
    14461 aagtacaagg aggatatatg cataagaaaa tattagttat ttgtttagta ctttttaatc
    14521 tatcaatatt tagtggatgt agtgctaaaa caaatccaag tacagaagtt aaaacctatc
    14581 ctgtaaaaac tatagagctt caagataaaa attatcctgt ttcattagaa tatgaaggga
    14641 taacaggtgg aagtgaagtt agaaagcttt cttttaaaag ttcatcaaaa atttcaaaaa
    14701 tattcgtttc aaaaggtcaa catataaaaa atggagacag ccttattgat ttagataaaa
    14761 ctgatttaaa ttccgcaaca gaagcttcaa aagctcaaat ggctgcagct tcagcgcaat
    14821 ataataaagc attaaatggt gcacaatctg aggatataaa caaagctcaa atagcagtaa
    14881 aaaatgctca ggctaattac aattactaca aagatttata tgataaaaat gttaccttat
    14941 atgaagcaca tgctatacca cagcaggagg ttaatgatac caaagttaaa ttagatggaa
    15001 gtgaaaatga cttaaattca gctcaagaaa cattaaagca gctccaaaat ggtacaagag
    15061 aagaagataa gcaagcagca ctagctcaat taaattctgc aaaagttgat tatgattcga
    15121 aagtcaattt gactcaagat gcttctctta aagccgatga agatggttat gtggtagata
    15181 ttctttgtaa agagggagaa atacaagcat caggaaatcc agttatctta attagaagtg
    15241 aaaatcaagt tgttactgta ggtttatctg atactgatgt aaagaaaata cagttaggaa
    15301 caaaagcaca agttaaaata gatgatgtta caactgacgg agaagttatg aatgtagttc
    15361 aaatggcaga taagcaatcc ggaacatata gtgcggaaat taaattgtta aatcaaatag
    15421 ataatagtaa attttacata ggtcaatgtg caaaagttta tattaatgaa ggtgaaaaga
    15481 atggaatttg gattcctatc gcaagtattt taaatgacgg tcaagactat gtatatgtag
    15541 tagaagacgg acgtgccgtt aggaaaaaca taactttagg acaaactaat gaaaatcaag
    15601 tgtgtgtaga tggattaaag aacggagata atcttgttaa tgaaggtatg aaaaatataa
    15661 aagctggata tcaggtttca gtagaataaa ggaggatgaa ttatgggatt gattaatgct
    15721 gctataaaaa ataagaagat agtgatgttt ttggtgcttc tttctataat aagtggtttt
    15781 atctgttact attacattcc taagcaggaa agtccagatg tttcatctcc agcggcaatg
    15841 ataacaacta tttatccagg ggcttctcct aaagatgtag aaagtttagt tacaaaaaag
    15901 attgaagata aaattgaaga aatagatgga tatgattatg ctgagtctta ttctcaaaat
    15961 agcgcatcta tagttattgt ttacttaaat aatgatgcag ataaagataa agcatggcgc
    16021 agcttgagag acaaaataaa agatttaaaa gctgagcttc cagatggctg tgaggatagt
    16081 aaaatagaca ccaaccttac tcaaactgca ggtatgattt taagtataac tggtgaaagt
    16141 tattcttatg agcaattagg aaattatgca gatgatataa agaaacaact aagtaatgtt
    16201 agtggtattt ctagatttga tataaaggga aaacaggata aacaagtaaa agtaaaagtg
    16261 gatttaagta aaataaataa atattctatt tctcttgaag atgtatgtgg tgtattacaa
    16321 tcacaaaatg tagagattcc ttctggatct ttggaactag cgactggaaa aataaaagtg
    16381 cagacacccg ggagctttac atcgcttaaa gacatagaaa atacaattgt gggagtttca
    16441 acagaaaccg gacaaactat aaaacttaaa gatatcgcta gtataaatat ggattatgat
    16501 gatgattcca attataaata tactgataat ggagaaaatg cagtattgct tgcagggtat
    16561 tttcaagata ataaaaatat agttttaata ggtgatgatg taagaaaaaa attagatgaa
    16621 ataaaaaagc aattgccaca ggatttaaat atagaagagg ttaccttcca gcctaaagat
    16681 gtaaatgagt cagtttcttt ctttatggaa aaccttagag atggtgttat tcttgtagtt
    16741 ataactgttc taataggaat gggtattaga aatgcactag tagtatcctc agtaattcca
    16801 atatctattg ctatgtcatt tattgctatg gagcttcttg gaatcaaggt gcatcaaatt
    16861 tctacgacag cacttattat agcacttgga atacttgtag atgatgcaat tgtaatagga
    16921 gatgttgttc aggtaggaat tgatgaggga ttaccaggag atgaggctgc atttaaagga
    16981 attaaaaaat tatttgtgcc tgtatttacc tccacattaa ttatagttgg tgcctttgca
    17041 cctctgctaa gcataccagg agcagtcggc gaatttataa gaacgcttcc acaagtagta
    17101 atgatttgta taacttgctc atatatatca gcgctattaa ttactcctgc tatgtcatct
    17161 ttatttttta aaaagagtaa aaaggctgaa aaggaaaata aaattcaaaa attattatct
    17221 aagcttttaa cttatggact taatcataaa ataaagatta ttgcagcatc tttacttata
    17281 ttttcagtat caatgggatt gatgaattta ttgagttcac aattcttccc ttatgtagat
    17341 aaaaatatta tttatataaa tgtgtctaat gaaaaagttg aagatttgga tagtacaaat
    17401 aatttagtga aagaagtaga aaatgtttta aaatcacaag aagaagttac gaattatact
    17461 tcagccatag gtggtggtct gcctagtttt tatgttacat tgcctactgt gacaccatca
    17521 aaagatacag ctcaaattat ggtaaaagta gatctagata aaactaaaaa gtttgataca
    17581 agagaaaaac tcgttgaaca tatacaaagt gaattagaca ataaaatctc tggtggaacg
    17641 gctacagtta aacttttaga acaagcagat ccaataggag cacttgttag aatgcgtctt
    17701 acaggagatg atttagataa aatttatact gcttcagagc aaatacaaga aaatttaaaa
    17761 aatataccag ggactacaaa tgtaagagac gatgcagcta aaaagacata tgaatatgaa
    17821 gtaaatatag atagtacgaa agcatctcaa tatggtttgt taaagtctga tattttgaaa
    17881 caaatgaaca ttgcattaaa aggatatagc agttctgtat ataggaaaag tggaagcgaa
    17941 tacgatatat tagtcaaaag taatattgct tcagtagaag atttgaaaaa tcttcaagta
    18001 aaatcaagtg ttacaaataa taaaatattg ttatcacaag tagcatctat aaatcttaat
    18061 tctgagttag atcaaataaa gcattataag aaagataaga ctgtaacagt atatagtgat
    18121 ttaaaatcag gatataactc aagtgatata gaaaatacag tcaaaactga aattaataaa
    18181 atggacttaa atggtgtaaa tgttctttat gatggagaac aaaaacaaat agaaaataac
    18241 ttctcaaatc ttgctattgc tggagtgctt attatagtaa taatttattt aattctattt
    18301 gttcaattta agtcatttat acaaccaatt gtaatactct attcactacc attatcacta
    18361 ataggagtaa tagtaggact tttgatgtgt gacatgccac tatctttaac tgctgtaatg
    18421 ggaataataa gcttgattgg agttgttata agaaatgcaa ttctgcttgt agaatatata
    18481 attgagggaa gacatgaagg gctttctata gatgaagctt gtgtgcatgc tgtaagtcaa
    18541 agatttagac caataatatt aagttcaact gcaactatta cagggcttat accacttgca
    18601 ttttctaaaa gtgcattatt tggacctatg tctgttacta taatatttgg acttgcgtct
    18661 gctactttcc ttacatttat agttgttcct gtaatgtatt ctttagttaa tactcaactt
    18721 gaaaagaaaa gacaacataa ttttttacaa attttaaaaa atgtattgca taaatataaa
    18781 aaatgataat tatttgataa aacctctata taaactatag atcatactta tgtgtgaact
    18841 caccgaaatc atatatatat ttgtttcgtc ggacttatga aattttcgtt ggaagattct
    18901 aaatgggagc ttgtgcccat ttctgcatgt tccaaatatt aattttgaca agcagtaaat
    18961 gtaacaagct cccattaaga atcttcaaca gctaaatttc aaatgattcc ttcacaaata
    19021 tatatatgat ttctagtgga gatgttaacc ctaaataagt tgaattctta aattgggtat
    19081 ctataattta aacttcccaa tatattctaa ctagaaagca agaggattct tttgtttgat
    19141 taatatagaa acattctaaa ttcaatcaag caaaagaatc ctcttaactt tttataaatt
    19201 accacataag tctaaatttt aagttataga tatccatatt gcctcagtta ttcttgataa
    19261 cacacaatag gagttcctgg ttcaatattt tcaaatattg tctttgctaa ataatatggt
    19321 gaatttacac agccatgaga accacttgtc ttataaatag ttcctccaaa aacaccattt
    19381 ctccaacttg catcatgtat tccaatatta ccattaaaag gcatccagta atcaactggt
    19441 gagctataat tttctccttt taatgtagca tttttttctt tataatttaa aacataagtc
    19501 cctgctggtg ttcccgtatt attacttaca ttacctgtaa caacatctcc ttctacaacc
    19561 aaggctcctt ttttataaaa ccatacatgt tgctttgtta aattaacttc tacatatgta
    19621 tcgccaatat cattgctatc tttagatact gctgtttgtg aatatgctgg ttcctttgtt
    19681 acatcctgac caccttttac agcttcaatt aaatccttca cttctttaga tttatttaca
    19741 atccatccat aattaccacc atcaacttgc actgtagttt tagatgatgt aacaaaactt
    19801 cttgtagaac caaaagtatt ataaatgccc gctattttat ctacataact cttaacctta
    19861 ttttcatcaa aagtaacttc catattgtca tttactccaa gccaagtatt tatggttgat
    19921 ccatctaaaa cttccttagt tccatgagaa tcataagtaa tttttaaaga tgcatattta
    19981 ttaagagtat cttttgcatt ttgaacttct tctgactttg aagtatactg tggattttca
    20041 taactattat ccgtacctaa atctatagat tcttctccat taagaattgc atccgctaca
    20101 ttatcatgta gagcatctat atttatctta tctcctaaaa cttcatccac aatttgataa
    20161 cttccatctt tatattcaaa acttgcattt tgaggtcttg ttaccttttt cttattaaca
    20221 catgaaagat tgcttaaagc tttatttaat aagtcttcat catatgaata tatttgggaa
    20281 tcatcagtat catctttctt aaaaagagta gctatccatc caagtgaact ttgattatcc
    20341 tttaattgtt taatcttatc agaatcatat tttaatccaa tatcagtacc tttaatttct
    20401 tcttttgaat ctcctctttc atctaattca agcttatatg attgaatttc agatgataaa
    20461 atgtcctctg ccttcgtaac actttttccc ccaacattaa caccatcaat cttggttcca
    20521 aaattaaaat gagtagtaga atataatgct attcctaaat atatagctgc taaacaacca
    20581 atggaagcta tggttttctt catcatttta ctttgtttat tttttgctct ttttaatctc
    20641 ccaagttttt tttcttcttt ttcccccat
//
