LOCUS       NC_022571.1            19366 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_022571.1 Clostridium saccharobutylicum DSM 13864, complete
            sequence.
ACCESSION   NC_022571
VERSION     NC_022571.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:03:18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 588141
            Orig. end    :: 607507
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..648)
                     /locus_tag="ctg1_492"
                     /transl_table=11
                     /translation="MINLCIINGSPRKGKGTSSYLINELTKLLSTNVKSKEYYISNLVN
                     NENSLNELLLYDKVIFISPLYADCFPSTMLNFLATFEDFLKDKNTPNIDMYGLVNCGFL
                     EGIQNKIALDILKNYSKRINFNWRFGLGIGGGEFLKGSKNIPLNSRMKKPVYNAFLTLK
                     NDIEDNSNNSINNIFTNAKMSKLIFKLAGNHGWKSMAKKNNLKVKDLYKQIY"
     protocluster    1..19366
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[597850:598453](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(9710..10312)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..19366
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..19366
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="3"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(663..1172)
                     /locus_tag="ctg1_493"
                     /transl_table=11
                     /translation="MLLIHDLNVDDSKELTSVLPPNSRVLSKEIDNINGCLGCFNCWLK
                     TPGRCIIEDSYTEMPKYILEGDTFVILTEIKYGCYTSYVKNVIDRSIGILLPFFQTVNG
                     ELHHLPRYKKDLKFIVIGYNKNITFDEEETFKDLVRRNAINLCIPDYEVYIIKDISESK
                     KILKNL"
     CDS             1607..2200
                     /locus_tag="ctg1_494"
                     /transl_table=11
                     /translation="MQVDKYHHGDLKESLIKMGLKLFNEEGAEKFSIRKVAAMCNVSHS
                     APYKHFKNKEELINAISEYVFYNFKNSLNEIVEKYKDNPGERIIQLGKKYVAFMVENPD
                     YLKFAFLTNSEYKITIEKNTLKSEECGTFKVFENCAFEFLQSVNVKEEKYAQDIIAMWS
                     MVHGLATMLSNKTFTYKGDYLSLVENILRNNLRF"
     PFAM_domain     1652..1789
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_494_0026"
                     /evalue="1.50E-10"
                     /label="ctg1_494"
                     /locus_tag="ctg1_494"
                     /protein_end="61"
                     /protein_start="15"
                     /score="40.8"
                     /tool="antismash"
                     /translation="IKMGLKLFNEEGAEKFSIRKVAAMCNVSHSAPYKHFKNKEELINA
                     I"
     CDS             2256..2645
                     /locus_tag="ctg1_495"
                     /transl_table=11
                     /translation="MYNMKEEYKIGLDHIDKQHEKLFELANKAYMLLKDEFAVDKYDKI
                     VEIINELKEYTIFHFKSEEEYMESINYKGLFSQKLQHEKFINVLQELDFKQIDENQDES
                     LIKVLDFLNDWLSDHILISDKFIGK"
     aSDomain        2268..2636
                     /aSDomain="TIGR02481"
                     /aSTool="tigrfam"
                     /description="hemeryth_dom: hemerythrin-like metal-binding
                     domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_495_0008"
                     /evalue="1.20E-27"
                     /identifier="TIGR02481"
                     /label="ctg1_495"
                     /locus_tag="ctg1_495"
                     /protein_end="127"
                     /protein_start="4"
                     /score="94.5"
                     /tool="antismash"
                     /translation="KEEYKIGLDHIDKQHEKLFELANKAYMLLKDEFAVDKYDKIVEII
                     NELKEYTIFHFKSEEEYMESINYKGLFSQKLQHEKFINVLQELDFKQIDENQDESLIKV
                     LDFLNDWLSDHILISDKFI"
     PFAM_domain     2289..2618
                     /aSDomain="Hemerythrin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01814.25"
                     /description="Hemerythrin HHE cation binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_495_0027"
                     /evalue="3.20E-09"
                     /label="ctg1_495"
                     /locus_tag="ctg1_495"
                     /protein_end="121"
                     /protein_start="11"
                     /score="37.6"
                     /tool="antismash"
                     /translation="LDHIDKQHEKLFELANKAYMLLKDEFAVDKYDKIVEIINELKEYT
                     IFHFKSEEEYMESINYKGLFSQKLQHEKFINVLQELDFKQIDENQDESLIKVLDFLNDW
                     LSDHIL"
     CDS             3111..3695
                     /locus_tag="ctg1_496"
                     /transl_table=11
                     /translation="MNEKTSKLVKISLLSAIALILRYIEFPVLPLFPWLQMDLSDVPAM
                     LGTFGFGPIVGIIIELLKNVLILGIKGTSTAFVGEVANFLFGVALLVPAGLVYHKKKSK
                     KTAIIGMILGGIFMEVVAIIVNAYFLLPAYGMNMDSAQLMQYITLGLLPFNGIKSVIVS
                     VVTYVLYKKISVSIFKVEPNFGGSKNSAKTM"
     PFAM_domain     3129..3620
                     /aSDomain="ECF_trnsprt"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12822.9"
                     /description="ECF transporter, substrate-specific
                     component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_496_0028"
                     /evalue="6.20E-29"
                     /label="ctg1_496"
                     /locus_tag="ctg1_496"
                     /protein_end="170"
                     /protein_start="6"
                     /score="101.4"
                     /tool="antismash"
                     /translation="KLVKISLLSAIALILRYIEFPVLPLFPWLQMDLSDVPAMLGTFGF
                     GPIVGIIIELLKNVLILGIKGTSTAFVGEVANFLFGVALLVPAGLVYHKKKSKKTAIIG
                     MILGGIFMEVVAIIVNAYFLLPAYGMNMDSAQLMQYITLGLLPFNGIKSVIVSVVTYVL
                     Y"
     CDS             complement(3924..4367)
                     /locus_tag="ctg1_497"
                     /transl_table=11
                     /translation="MNVTVDLMEEEDIDGVLDISSLSFSLPWSKESYIQELNNPIAHYF
                     VARCDDIVVGFVGTWIILDESHITNIAVHPNYRTQGIASKLLDELLTYCKSKGCIAYTL
                     EVRASNENAQKLYLKHGFKKDGVRKGYYEDNKEDAILMWLRES"
     aSDomain        complement(3942..4334)
                     /aSDomain="TIGR01575"
                     /aSTool="tigrfam"
                     /description="rimI: ribosomal-protein-alanine
                     acetyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_497_0009"
                     /evalue="4.00E-44"
                     /identifier="TIGR01575"
                     /label="ctg1_497"
                     /locus_tag="ctg1_497"
                     /protein_end="142"
                     /protein_start="11"
                     /score="147.9"
                     /tool="antismash"
                     /translation="DIDGVLDISSLSFSLPWSKESYIQELNNPIAHYFVARCDDIVVGF
                     VGTWIILDESHITNIAVHPNYRTQGIASKLLDELLTYCKSKGCIAYTLEVRASNENAQK
                     LYLKHGFKKDGVRKGYYEDNKEDAILM"
     PFAM_domain     complement(4002..4322)
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_497_0029"
                     /evalue="1.80E-19"
                     /label="ctg1_497"
                     /locus_tag="ctg1_497"
                     /protein_end="122"
                     /protein_start="15"
                     /score="70.2"
                     /tool="antismash"
                     /translation="VLDISSLSFSLPWSKESYIQELNNPIAHYFVARCDDIVVGFVGTW
                     IILDESHITNIAVHPNYRTQGIASKLLDELLTYCKSKGCIAYTLEVRASNENAQKLYLK
                     HGF"
     CDS             complement(4351..5067)
                     /locus_tag="ctg1_498"
                     /transl_table=11
                     /translation="MIVLAVDSSSKVATVALMKDDKLLGEITLNDKKEHSVILMTIIED
                     LLKFNNLTIDDIDGYVVSKGPGSFTGLRIGMATVKGLSFGSGKPYVSLSSLDALAFSVA
                     NFDGLICPIMDALRNSVYTSLYKSCNGSLEKLMDYSALDMDELVEIIKSKGEKVIFIGD
                     GLDKYKDYLIENCPNCYFPPNHLNLVRASSLGEIGSKLLRDGQFDDPNSTPFYLKKPQA
                     EREYEQRMQLRNECNC"
     aSDomain        complement(4414..5061)
                     /aSDomain="TIGR03725"
                     /aSTool="tigrfam"
                     /description="T6A_YeaZ: tRNA threonylcarbamoyl adenosine
                     modification protein YeaZ"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_498_0010"
                     /evalue="6.30E-53"
                     /identifier="TIGR03725"
                     /label="ctg1_498"
                     /locus_tag="ctg1_498"
                     /protein_end="218"
                     /protein_start="2"
                     /score="177.9"
                     /tool="antismash"
                     /translation="VLAVDSSSKVATVALMKDDKLLGEITLNDKKEHSVILMTIIEDLL
                     KFNNLTIDDIDGYVVSKGPGSFTGLRIGMATVKGLSFGSGKPYVSLSSLDALAFSVANF
                     DGLICPIMDALRNSVYTSLYKSCNGSLEKLMDYSALDMDELVEIIKSKGEKVIFIGDGL
                     DKYKDYLIENCPNCYFPPNHLNLVRASSLGEIGSKLLRDGQFDDPNSTPFYLK"
     PFAM_domain     complement(4603..4998)
                     /aSDomain="TsaD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00814.27"
                     /description="tRNA N6-adenosine
                     threonylcarbamoyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_498_0030"
                     /evalue="4.00E-25"
                     /label="ctg1_498"
                     /locus_tag="ctg1_498"
                     /protein_end="155"
                     /protein_start="23"
                     /score="89.1"
                     /tool="antismash"
                     /translation="LGEITLNDKKEHSVILMTIIEDLLKFNNLTIDDIDGYVVSKGPGS
                     FTGLRIGMATVKGLSFGSGKPYVSLSSLDALAFSVANFDGLICPIMDALRNSVYTSLYK
                     SCNGSLEKLMDYSALDMDELVEIIKSKG"
     CDS             complement(5064..5525)
                     /locus_tag="ctg1_499"
                     /transl_table=11
                     /translation="MKFEINSVAETTQLGIKLGKLLNAGDIICLTGDLGTGKTHITKGI
                     AKGLGIDETITSPTFTIVNEYDSGRLKLNHFDVYRVSDPDEVYAIGFDDYIFSDAVSVI
                     EWANYIEEILPKDLLHIYIEKDLAKGEDYRKIILTPYGERYNYIKELTI"
     PFAM_domain     complement(5148..5510)
                     /aSDomain="TsaE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02367.19"
                     /description="Threonylcarbamoyl adenosine biosynthesis
                     protein TsaE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_499_0031"
                     /evalue="1.60E-39"
                     /label="ctg1_499"
                     /locus_tag="ctg1_499"
                     /protein_end="126"
                     /protein_start="5"
                     /score="134.9"
                     /tool="antismash"
                     /translation="NSVAETTQLGIKLGKLLNAGDIICLTGDLGTGKTHITKGIAKGLG
                     IDETITSPTFTIVNEYDSGRLKLNHFDVYRVSDPDEVYAIGFDDYIFSDAVSVIEWANY
                     IEEILPKDLLHIYIEKD"
     aSDomain        complement(5151..5501)
                     /aSDomain="TIGR00150"
                     /aSTool="tigrfam"
                     /description="T6A_YjeE: tRNA threonylcarbamoyl adenosine
                     modification protein YjeE"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_499_0011"
                     /evalue="1.50E-36"
                     /identifier="TIGR00150"
                     /label="ctg1_499"
                     /locus_tag="ctg1_499"
                     /protein_end="125"
                     /protein_start="8"
                     /score="123.2"
                     /tool="antismash"
                     /translation="AETTQLGIKLGKLLNAGDIICLTGDLGTGKTHITKGIAKGLGIDE
                     TITSPTFTIVNEYDSGRLKLNHFDVYRVSDPDEVYAIGFDDYIFSDAVSVIEWANYIEE
                     ILPKDLLHIYIEK"
     CDS             6138..7040
                     /gene_functions="transport (smcogs) SMCOG1252:cation ABC
                     transporter, periplasmic (Score: 82.9; E-value: 3.6e-25)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_500"
                     /transl_table=11
                     /translation="LKKITFAMVLITIVLSLGMSVFSSPLLANTENKSNAEMRDKYLNI
                     MTVNKPQYDMVKKIIKDKHNVQYMFTDEKEISEFKYNASVLENVSNMDLFIYSGATFEP
                     WANSFISELTKGNLGIINLSRGVRLLNYDEGATKENPYYFEGIDEYKIALCNVKAAIED
                     RDPKNRDFYEKNYNIAIKEFNDKLKSYDDKIKSLSDYTFITLNHDFDYLTKSLNLNIKE
                     LNNHELGEFIKSNNLDPKKVIVIVDGEQDPKINLSGYNTIKLWKYYGDWSFDDLILYNI
                     DELAKWAKPADKSSTGSVA"
     PFAM_domain     6270..6806
                     /aSDomain="ZnuA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01297.19"
                     /description="Zinc-uptake complex component A periplasmic"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_500_0032"
                     /evalue="1.00E-19"
                     /label="ctg1_500"
                     /locus_tag="ctg1_500"
                     /protein_end="223"
                     /protein_start="44"
                     /score="71.2"
                     /tool="antismash"
                     /translation="IMTVNKPQYDMVKKIIKDKHNVQYMFTDEKEISEFKYNASVLENV
                     SNMDLFIYSGATFEPWANSFISELTKGNLGIINLSRGVRLLNYDEGATKENPYYFEGID
                     EYKIALCNVKAAIEDRDPKNRDFYEKNYNIAIKEFNDKLKSYDDKIKSLSDYTFITLNH
                     DFDYLTKSLNLNIKEL"
     CDS             7665..8411
                     /locus_tag="ctg1_501"
                     /transl_table=11
                     /translation="LYSVILVEDNIEERNILKKMLLSISEFIKIYEADSEATALNIIQN
                     NDINMFLIDINLKQSSGLDLAMKIRSISKYEFRQIIFLTTHMAYITQAFKKTHCYDYIL
                     KPYDHKEVQVMLNKLILNESSYKDKVEEKELVITLKSGIYVGIKIREIIFIEVIGKNCE
                     VNTINGLYIANNMSLKKIMKLIDCDDIIQSHRSFAVNKDYISKIEKIDIKLSAVYFNNS
                     SKTALLGYKFKNNVIDEFKKGKVILC"
     PFAM_domain     7674..8009
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_501_0033"
                     /evalue="9.40E-15"
                     /label="ctg1_501"
                     /locus_tag="ctg1_501"
                     /protein_end="115"
                     /protein_start="3"
                     /score="54.9"
                     /tool="antismash"
                     /translation="VILVEDNIEERNILKKMLLSISEFIKIYEADSEATALNIIQNNDI
                     NMFLIDINLKQSSGLDLAMKIRSISKYEFRQIIFLTTHMAYITQAFKKTHCYDYILKPY
                     DHKEVQVM"
     PFAM_domain     8103..8336
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_501_0034"
                     /evalue="1.60E-08"
                     /label="ctg1_501"
                     /locus_tag="ctg1_501"
                     /protein_end="224"
                     /protein_start="146"
                     /score="34.8"
                     /tool="antismash"
                     /translation="IKIREIIFIEVIGKNCEVNTINGLYIANNMSLKKIMKLIDCDDII
                     QSHRSFAVNKDYISKIEKIDIKLSAVYFNNSSK"
     CDS             8405..9655
                     /locus_tag="ctg1_502"
                     /transl_table=11
                     /translation="MLGNFIMDALDTTIVFCLWKTINNKSKVNVFKQLLAILIIASLVA
                     AIEQLKLNFILIYIVYITVLKIIYNSNLIECVLIYFFIMLVDMALQLTFTIIIRPFITN
                     YTLKGIVIEVIILVISIIFLKLNKNRKITFEKINNNILVYLASTCIIYTMLFKIIWEYD
                     SNIILNNMFIVAVIWIILIFCQTLTYFHIIEITKETEKLKISNEYNVAINEIVQEIKQR
                     QHDFVNYKNTIKGMMEVLDEKELREAIYNYMKDEDEYDYKINELIYIDNAVIKSILYRN
                     MCKAKKYNVNLQYKIENNVLDDILSYQELSNILNNLLNNAFDEVIKEECINKNIKLEIV
                     NRNKESHLIIKNQIANVNDLNLNEMFERGFSTKNIGTRGYGLYNVKKIINLHKGFIKVN
                     IESGKIKFDFYFNNSSG"
     PFAM_domain     9326..9628
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_502_0035"
                     /evalue="1.50E-09"
                     /label="ctg1_502"
                     /locus_tag="ctg1_502"
                     /protein_end="408"
                     /protein_start="307"
                     /score="37.8"
                     /tool="antismash"
                     /translation="QELSNILNNLLNNAFDEVIKEECINKNIKLEIVNRNKESHLIIKN
                     QIANVNDLNLNEMFERGFSTKNIGTRGYGLYNVKKIINLHKGFIKVNIESGKIKFD"
     CDS             complement(9631..9750)
                     /locus_tag="ctg1_503"
                     /transl_table=11
                     /translation="MQKSINIFSAILLNLFNLVSKSSCGGMYGEPDYPEELLK"
     CDS             complement(9710..10312)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_504"
                     /sec_met_domain="AgrB (E-value: 1.9e-35, bitscore: 119.9,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKSFSTLICKHLKKNNSSLTKTDLLKMQYTLEVILGDISKLSLI
                     FIIFLFFNEIPLFFLIFVILISTRTLGGGIHCKTYTSCLIVSTIYFLSILLFSKSAIQL
                     NINFYIVFFIISFIITLTYAPCKNEKRPIKNKTTLKILSLISLTFWSILFFKLSDSKIY
                     NCIFLSILIQIIQLIIVNIKGVVRNAKIYKYFFSHTT"
     PFAM_domain     complement(9785..10291)
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_504_0036"
                     /evalue="5.20E-35"
                     /label="ctg1_504"
                     /locus_tag="ctg1_504"
                     /protein_end="176"
                     /protein_start="7"
                     /score="120.6"
                     /tool="antismash"
                     /translation="LICKHLKKNNSSLTKTDLLKMQYTLEVILGDISKLSLIFIIFLFF
                     NEIPLFFLIFVILISTRTLGGGIHCKTYTSCLIVSTIYFLSILLFSKSAIQLNINFYIV
                     FFIISFIITLTYAPCKNEKRPIKNKTTLKILSLISLTFWSILFFKLSDSKIYNCIFLSI
                     LIQIIQ"
     CDS             10731..11477
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_505"
                     /sec_met_domain="PF00561 (E-value: 2.6e-09, bitscore: 35.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYFKYQNFDIYYKVYGEGKPLVIIHGDTASSKMFIPELKFYSKN
                     FKVILLDLVGQGKSKRVDELPLNYWHFNAMVVIGLCKYIGVNNVNLLGTSGGAIVALNA
                     ALENSNLFNKIIIDSFMGENLPYEFAEKILVDRKIAKNKLSSKLFWFMMHGFDWKYVID
                     QNTNLIMNFAREKGDFFECNLNNIKNDILITGSLKDDLIPNIENILKNINSKIENSKLV
                     IFKYGNHPAMFSNKKEFRNLVLNFLM"
     PFAM_domain     10788..11099
                     /aSDomain="Abhydrolase_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00561.22"
                     /description="alpha/beta hydrolase fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_505_0037"
                     /evalue="1.20E-08"
                     /label="ctg1_505"
                     /locus_tag="ctg1_505"
                     /protein_end="123"
                     /protein_start="19"
                     /score="35.1"
                     /tool="antismash"
                     /translation="KPLVIIHGDTASSKMFIPELKFYSKNFKVILLDLVGQGKSKRVDE
                     LPLNYWHFNAMVVIGLCKYIGVNNVNLLGTSGGAIVALNAALENSNLFNKIIIDSFMGE
                     "
     CDS             11937..12698
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 209.7; E-value:
                     8.2e-64)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_506"
                     /transl_table=11
                     /translation="MLVLKVKKLKKTYKNNTNKTNALNGIDFTVGQGEFVGIMGPSGSG
                     KTTLLNVLSGISKPTAGEIEILGQSVKDMSKHEMTLFRRKHLGFVFQDFNLLDSLTLEE
                     NIMLPLSLESYESEERYKKVNKVMTMFNIVNVKHKYPYLVSGGQQQRAAIGRAIINKPD
                     IIFADEPTGNLDWKSSNIVMNYFERLNLENKNTILVVTHDPFTASYCKRIIFIKDGLIH
                     SEITNNDNDKQIFFDKILENLNNIGDEKDDL"
     PFAM_domain     12003..12449
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_506_0038"
                     /evalue="2.00E-33"
                     /label="ctg1_506"
                     /locus_tag="ctg1_506"
                     /protein_end="171"
                     /protein_start="22"
                     /score="115.9"
                     /tool="antismash"
                     /translation="LNGIDFTVGQGEFVGIMGPSGSGKTTLLNVLSGISKPTAGEIEIL
                     GQSVKDMSKHEMTLFRRKHLGFVFQDFNLLDSLTLEENIMLPLSLESYESEERYKKVNK
                     VMTMFNIVNVKHKYPYLVSGGQQQRAAIGRAIINKPDIIFADEPT"
     CDS             12688..14583
                     /gene_functions="transport (smcogs) SMCOG1243:ABC
                     transporter, permease component (Score: 197.6; E-value:
                     6.2e-60)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_507"
                     /transl_table=11
                     /translation="MTFKELSIRMFKSNIRRYTLYFACSGFITMVLFLYLTLYTNKDFN
                     NPYKVDSSISGNLFAPTLVLFIFATCFIIYAHNYFIKFRKKDFALFMIIGMTENDIRKI
                     ILLENIIIAIISVLVGLFLGTCLSKVFYFVVSQLANLKIDFSINLKSYLYTIVFLSLVN
                     LIMILKSCIFIPLYQIINLLKAQHKADNNFSGNPFFGVLGVIFMLIPYIRVFDNRFSFS
                     FFAVILINLIGLYLLISNLHWFIKKFFKSNSFDNLIWINNLKYSIGNSKKIIFSITALI
                     ASILYFISFSYSANESINNNIIIQNPYDLAYAEIYGKNEISEDTLNNTLKSNDVKVESI
                     NSLEIVVQGSTVMISDKSLNNLLGSNFNVERGKYICLLQINRNDGYVHNEQEIENYTIN
                     NTTYILQEKLEKILFNKIPILNNSHYLIFNQDDYKEIKSSVKSKYIGNVKFINFNDWTK
                     TETVVNNLTDELENYNKINTKQFFGSTNDDRRQFKPVSKIIDYKLLKESSQFLTFLLCF
                     VFILFFISSNLIIHFKLLTEFDNEKIKYEKLNKIGVLEKEISSNISKELSIIFLLPCIL
                     GTYLGTYCIYSKIASIGISNLHEIRYALITGVAYTVLELIFYLFYKKHYINLLLK"
     PFAM_domain     12940..13197
                     /aSDomain="FtsX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02687.23"
                     /description="FtsX-like permease family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_507_0039"
                     /evalue="2.40E-08"
                     /label="ctg1_507"
                     /locus_tag="ctg1_507"
                     /protein_end="170"
                     /protein_start="84"
                     /score="34.4"
                     /tool="antismash"
                     /translation="KKDFALFMIIGMTENDIRKIILLENIIIAIISVLVGLFLGTCLSK
                     VFYFVVSQLANLKIDFSINLKSYLYTIVFLSLVNLIMILKS"
     CDS             14710..16035
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 283.2; E-value: 5.3e-86)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_508"
                     /transl_table=11
                     /translation="MKKIDLTEGKVINVITALALPIMGSSLLQFTYNLVDMLWVGGLGS
                     NAVASIGSSSLYIGLGYSINSLVVIGAGIKVAQGIGRKDNNQVKEYINAGIFINLLMGL
                     ILGSALIFVGKELIGFLHIENVVVERDAYYYLALNGPILFFTFFNTLYARILGSFGNNK
                     LALKINALGLALNIILDPMFIYTFKFGVLGAAISTLIANIIMFIVYLVKSSGILKFNFQ
                     AGIDKNKIIKIIRLGLPMVFQRILFTIINIMLAKIVASFGSDAIAGQKIGLEIESVMYM
                     VVGGLNGAVSSFTGQNFGAKKFNRIKEGYNGALKIGIIYSLIIALAFLFLNKPLIRLFI
                     REENTIMIAAAYLQMVAFSQVFSTLEMVSNGLFTGIGKPNIPATISVVFTALRIPMSLI
                     LIKPFGVNGIWISIALSSILKGSFAYLLYCVKVKRKYKEVKI"
     PFAM_domain     14770..15255
                     /aSDomain="MatE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01554.20"
                     /description="MatE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_508_0040"
                     /evalue="2.70E-21"
                     /label="ctg1_508"
                     /locus_tag="ctg1_508"
                     /protein_end="182"
                     /protein_start="20"
                     /score="76.0"
                     /tool="antismash"
                     /translation="PIMGSSLLQFTYNLVDMLWVGGLGSNAVASIGSSSLYIGLGYSIN
                     SLVVIGAGIKVAQGIGRKDNNQVKEYINAGIFINLLMGLILGSALIFVGKELIGFLHIE
                     NVVVERDAYYYLALNGPILFFTFFNTLYARILGSFGNNKLALKINALGLALNIILDPM"
     aSDomain        14770..15939
                     /aSDomain="TIGR00797"
                     /aSTool="tigrfam"
                     /description="matE: MATE efflux family protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_508_0012"
                     /evalue="1.70E-70"
                     /identifier="TIGR00797"
                     /label="ctg1_508"
                     /locus_tag="ctg1_508"
                     /protein_end="410"
                     /protein_start="20"
                     /score="235.9"
                     /tool="antismash"
                     /translation="PIMGSSLLQFTYNLVDMLWVGGLGSNAVASIGSSSLYIGLGYSIN
                     SLVVIGAGIKVAQGIGRKDNNQVKEYINAGIFINLLMGLILGSALIFVGKELIGFLHIE
                     NVVVERDAYYYLALNGPILFFTFFNTLYARILGSFGNNKLALKINALGLALNIILDPMF
                     IYTFKFGVLGAAISTLIANIIMFIVYLVKSSGILKFNFQAGIDKNKIIKIIRLGLPMVF
                     QRILFTIINIMLAKIVASFGSDAIAGQKIGLEIESVMYMVVGGLNGAVSSFTGQNFGAK
                     KFNRIKEGYNGALKIGIIYSLIIALAFLFLNKPLIRLFIREENTIMIAAAYLQMVAFSQ
                     VFSTLEMVSNGLFTGIGKPNIPATISVVFTALRIPMSLILIKPFGVNGIW"
     PFAM_domain     15424..15903
                     /aSDomain="MatE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01554.20"
                     /description="MatE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_508_0041"
                     /evalue="9.90E-30"
                     /label="ctg1_508"
                     /locus_tag="ctg1_508"
                     /protein_end="398"
                     /protein_start="238"
                     /score="103.4"
                     /tool="antismash"
                     /translation="PMVFQRILFTIINIMLAKIVASFGSDAIAGQKIGLEIESVMYMVV
                     GGLNGAVSSFTGQNFGAKKFNRIKEGYNGALKIGIIYSLIIALAFLFLNKPLIRLFIRE
                     ENTIMIAAAYLQMVAFSQVFSTLEMVSNGLFTGIGKPNIPATISVVFTALRIPMSL"
     CDS             16199..17167
                     /locus_tag="ctg1_509"
                     /transl_table=11
                     /translation="MEELTIALLIDADNIGAKHIENILGELTKYGRVTIRRMYGDWTQE
                     RLKSWLEKSSQFSLTPIMQSNDTSRKNASDIGLVIDAMDILYSEKVNGFCIVSSDSDFN
                     KLAKRLRESGNLVIGMGEQKTPESFRASCEKFIYLDIIDEDIELEDEKLDIEVGNNESS
                     KKYFEEKSFTKKSIIEKTIINMILDSTMDTMHLGEIGQRINNMFPDFDVRNYHYTKLSE
                     LLKEFDSLTLSNKENKYWVALKNIMPENIKEIENKIVVIFNKKRVSKMNIGELKKELSS
                     VIPNLNIVIKKSGVTKFSVFLDKKIDIITISDDNNNAELIK"
     PFAM_domain     16214..16618
                     /aSDomain="NYN"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01936.20"
                     /description="NYN domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_509_0042"
                     /evalue="2.30E-27"
                     /label="ctg1_509"
                     /locus_tag="ctg1_509"
                     /protein_end="140"
                     /protein_start="5"
                     /score="96.4"
                     /tool="antismash"
                     /translation="IALLIDADNIGAKHIENILGELTKYGRVTIRRMYGDWTQERLKSW
                     LEKSSQFSLTPIMQSNDTSRKNASDIGLVIDAMDILYSEKVNGFCIVSSDSDFNKLAKR
                     LRESGNLVIGMGEQKTPESFRASCEKFIYLD"
     PFAM_domain     16730..16909
                     /aSDomain="OST-HTH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12872.9"
                     /description="OST-HTH/LOTUS domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_509_0043"
                     /evalue="1.60E-09"
                     /label="ctg1_509"
                     /locus_tag="ctg1_509"
                     /protein_end="237"
                     /protein_start="177"
                     /score="37.6"
                     /tool="antismash"
                     /translation="IEKTIINMILDSTMDTMHLGEIGQRINNMFPDFDVRNYHYTKLSE
                     LLKEFDSLTLSNKEN"
     CDS             17329..17763
                     /locus_tag="ctg1_510"
                     /transl_table=11
                     /translation="MFNENKMNSSKDKTLILSIVNSQCFKDLFINRGITNVIIFGSLAN
                     GDFTPESDVDIAIISKTPISFNDELILTQKLEELLDRDIDLIDINDENINNLIKISALN
                     SKFVVLKDYLLDETIIFYDNLYKDNEEFWRILDQEVLGIE"
     PFAM_domain     17416..17643
                     /aSDomain="NTP_transf_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01909.25"
                     /description="Nucleotidyltransferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_510_0044"
                     /evalue="5.10E-11"
                     /label="ctg1_510"
                     /locus_tag="ctg1_510"
                     /protein_end="105"
                     /protein_start="29"
                     /score="42.8"
                     /tool="antismash"
                     /translation="INRGITNVIIFGSLANGDFTPESDVDIAIISKTPISFNDELILTQ
                     KLEELLDRDIDLIDINDENINNLIKISALNS"
     CDS             17756..18028
                     /locus_tag="ctg1_511"
                     /transl_table=11
                     /translation="LNKERLKKLLYDLDTTTKDLNKSLQLVKKYSDNSELKSEFSNSLK
                     YKYLRLFIIYEDFISMLSKEYNQYEIGMTIDKAAFDLNLYKKNIK"
     CDS             complement(18092..18550)
                     /locus_tag="ctg1_512"
                     /transl_table=11
                     /translation="MLKEGLIILLFLTVLIGFIFLLYYMGILKRKVVVTIVDVLPLGLF
                     KDTSTNLEEQILEDHDHENSNSDELNLIKLDNENSINELQENSNSKSLELFEENSIQEI
                     KNEEIVYWTPQGKHYHKTKNCRTLLRSKVVNSGSIEESGKLTGCNQCN"
     CDS             18824..19366
                     /locus_tag="ctg1_513"
                     /transl_table=11
                     /translation="MKKFVCTVCGYIYEGEAAPEKCPVCGVGADKFIEQSGDLAFADEH
                     VIGVANGVDKEIIEGLQANFAGECTEVGMYLAMSRQADREGYPEVAEAYKRIAFEEAEH
                     AAKFAEMLGEVVVADTKANLEARVNAEHGACQGKKDLATLAKKLNLDAIHDTVHEMCKD
                     EARHGKAFKGLLDRYFA"
     PFAM_domain     19004..19345
                     /aSDomain="Rubrerythrin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02915.19"
                     /description="Rubrerythrin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_513_0045"
                     /evalue="1.40E-13"
                     /label="ctg1_513"
                     /locus_tag="ctg1_513"
                     /protein_end="174"
                     /protein_start="60"
                     /score="51.5"
                     /tool="antismash"
                     /translation="LQANFAGECTEVGMYLAMSRQADREGYPEVAEAYKRIAFEEAEHA
                     AKFAEMLGEVVVADTKANLEARVNAEHGACQGKKDLATLAKKLNLDAIHDTVHEMCKDE
                     ARHGKAFKGL"
ORIGIN
        1 tcaatagatt tgtttataaa gatctttaac ttttagatta tttttcttag ccatggattt
       61 ccaaccatga ttgcctgcaa gtttaaatat aagtttagac atttttgcat tagtaaatat
      121 attatttatt gaattattag aattatcttc aatatcattt tttaaagtta agaaagcgtt
      181 ataaacaggt tttttcatac gagagtttaa aggaatgttt ttagagcctt taagaaattc
      241 accgccacct ataccaagac caaatcgcca gttaaaattt attctcttag aataattttt
      301 taaaatatca agagctattt tattttgaat gccttctaag aatccacaat taacaagtcc
      361 atacatatca atatttggag tgtttttgtc tttaagaaaa tcttcaaatg tagcaagaaa
      421 atttaacatt gtgcttggaa aacaatctgc atataaaggg gaaatgaaaa taactttatc
      481 atataataaa agctcattta acgaattctc attgttaaca agattgctta tatagtattc
      541 ttttgattta acattagtac ttaataattt agttaattcg tttataagat aactagaagt
      601 accttttcct tttcttggac ttccatttat aatacataaa ttaatcatag aataaaccct
      661 ccctacaaat ttttaagtat ttttttagat tcggatatat ctttaattat ataaacttca
      721 tagtctggaa tacataaatt aatagcattt cttctaacta aatctttaaa agtttcttct
      781 tcatcaaaag taatattttt attatatcct attacaataa atttaaggtc ttttttataa
      841 cgaggaagat gatgaagctc accattaact gtttgaaaaa aaggcaataa aatgcctatt
      901 gatctatcaa ttacattttt tacgtaagaa gtatagcagc catattttat ttcagttaga
      961 attacaaaag tatcaccttc taaaatatat tttggcattt ctgtatagga atcttcgata
     1021 atgcatctac ctggtgtctt gagccaacaa ttaaaacatc ctaagcaacc attaatatta
     1081 tctatctctt ttgaaagtac tcttgaatta ggaggtaaca cagatgtaag ttcttttgaa
     1141 tcgtcaacat ttaaatcatg aattaataac atagaaagtc tcctttttat tcacagaaat
     1201 atatacaaac taacaagtat atatttgttg aaattttata tttatttgta atttttatat
     1261 tagggtaatt ttaagttata tttattaata aatatatgtt tacactgtca acttaatgat
     1321 agagtagcac ttaaagttta cactgtcaac atgttatgat attatataga ttacaaattt
     1381 aatttttcat taaaatcaag tttctattac taaattattt ttgaattata catatgttgc
     1441 aatatgattt gtgaattgat ttatttatac agtacatagt tttaatgtag atttcaattt
     1501 tcaatatata tgttaaaaat attatagata atataaaaaa agtattaata atatattttg
     1561 aattttagta aatttatata taaaatttag gaaagaggtt ttacgtatgc aggtcgataa
     1621 gtatcatcac ggagatttaa aagaaagtct aataaagatg ggactaaagt tatttaatga
     1681 agaaggggca gaaaaatttt caataagaaa agtcgccgca atgtgcaacg taagtcattc
     1741 agctccatat aaacatttta aaaataaaga agaactgatt aatgcaatat ctgaatatgt
     1801 attttataac tttaaaaact cactaaatga aatcgtggag aagtataagg ataatccagg
     1861 tgaaagaatt atacaattgg gaaaaaaata tgttgctttt atggtagaaa atccagatta
     1921 tttgaaattt gcgtttttaa caaattcaga gtataaaata actatagaaa aaaatacact
     1981 aaaaagtgaa gagtgtggaa cgtttaaagt atttgaaaat tgtgcttttg aatttttaca
     2041 aagtgtaaat gttaaagaag aaaaatatgc acaagacata attgccatgt ggtcgatggt
     2101 acatgggctt gctacgatgt tgtcaaataa gacatttaca tataaaggag attatcttag
     2161 tttggttgaa aatatattaa gaaataatct tagattttaa attgtggagc taaaatgtaa
     2221 aattgattta aatttatata aaggagatta ttattatgta taatatgaaa gaagaatata
     2281 aaattggatt agatcatatt gataagcagc atgaaaagct ttttgagttg gctaacaaag
     2341 catatatgtt attaaaagat gaatttgctg ttgataaata tgataaaata gtagaaataa
     2401 taaatgaatt aaaggagtac actatttttc attttaaatc agaagaagaa tatatggaaa
     2461 gtataaatta taagggatta tttagtcaaa aactacaaca tgaaaaattt attaatgttc
     2521 ttcaagaatt agatttcaag cagattgatg aaaatcaaga tgaaagtttg ataaaagtgt
     2581 tagatttttt aaatgattgg ttatctgatc acatattaat aagtgataaa tttataggaa
     2641 aataaggaac aatcaaaaaa ataatagtct attttttgca ttataatcat atttatttaa
     2701 tagattacca ttaggtaaac atattatttt cttatttgat tgtaaaaata tattatagac
     2761 taatttattt tgttatagat gttgttgtaa tatgattaat taagagatat aataaaatta
     2821 ataaaaaata tatcttcagg gcagggttaa aatccctacc ggcggtatag cccgcgagct
     2881 ttaatttaag cagattcggt gtaattccga agccgacagt atagtctgga tgaaagaagg
     2941 taacctatta gtatttaaga gtttagttat tcttatttat ttgaatgtat gccctgatgt
     3001 atttaacatc agggtttaat ttttttgtta atgaatttaa aataagatta ttttcaaagg
     3061 ctaaatacta ataagctaca ccaggagata acttttggga ggcaaagaaa atgaatgaaa
     3121 aaacaagtaa actagtaaaa atttctttat tatcggctat agcacttata cttaggtata
     3181 tagaatttcc agtattacca ctattcccat ggctgcaaat ggatctaagt gatgtaccag
     3241 caatgttagg gacatttggt tttggaccaa tagtaggaat aataattgaa ctattgaaaa
     3301 atgttttaat attaggaata aagggaacaa gcactgcttt tgttggagaa gttgcaaact
     3361 ttttatttgg agtagcacta ttagtaccag caggacttgt atatcataag aagaaaagta
     3421 agaaaactgc tattataggc atgatattag gtggtatttt catggaggta gtagctatta
     3481 tagtaaatgc atatttctta ttacctgctt atggaatgaa tatggacagt gctcaactta
     3541 tgcaatatat tactttagga ctattacctt ttaatggaat aaagtctgtt atagtatcag
     3601 tagtaacata tgtattgtat aaaaaaatat ctgtgtcaat atttaaagtt gaacctaatt
     3661 ttggtggttc taaaaatagt gcaaaaacta tgtaagtaga ttctgcaacc aagataagga
     3721 cagagttagc aatcatagaa aagtaaaaat atagtttaag aattaaatta aaaaatacat
     3781 ataaattgca aagagattta tatagaatct aagcaattta tatgtatttt attttttatt
     3841 aaacttatgc atatatatct aaataagtga tattttttag ttgcttaatc gctttactat
     3901 aagtttaaat gttattaaga attttaactt tctcttagcc acattaatat ggcatcttct
     3961 ttattgtctt cataatatcc ttttctaact ccatcttttt taaaaccatg tttaagataa
     4021 agcttttgag cattttcatt gctagctctt acctcaagag tataagcaat acatccctta
     4081 gacttacagt atgttagcaa ttcatctaat aatttagaag caattccttg cgttctatag
     4141 ttagggtgaa cagctatatt tgttatatga gattcgtcta atataatcca agtaccaaca
     4201 aatcctacta ctatatcatc acatcttgca acaaagtaat gtgctattgg attatttaat
     4261 tcttgaatat aggattcctt gctccaagga agagaaaaac ttaaggaact gatatctaaa
     4321 actccatcaa tatcttcctc ttccattaaa tcaacagtta cattcatttc ttaattgcat
     4381 cctttgttca tattctctct cagcttgtgg cttctttaaa tagaatggag tggagttagg
     4441 atcatcaaat tgaccatctc ttagcaattt actacctatt tcacctagag atgatgcacg
     4501 aactaaattt aagtgatttg gagggaagta acaatttgga caattttcaa ttagataatc
     4561 tttgtattta tctaatccat ctccaataaa tattactttt tctcctttag acttaattat
     4621 ttctacaagt tcatccatat caagtgcaga ataatccata agtttttcaa gtgaaccatt
     4681 gcaactctta tataatgaag tataaacgct atttcttaga gcatccatta ttggacagat
     4741 aagtccatca aaattagcaa cgctaaatgc taaagcgtct aagctggata ggctaacata
     4801 aggtttaccg cttccaaagc taagtccttt tactgttgcc attcctattc taagtccagt
     4861 aaaggaacca ggccccttag aaacaacata gccatcaata tcatcaatag ttaaattatt
     4921 aaattttaat aaatcttcaa ttatagtcat taatataaca gaatgttctt ttttatcatt
     4981 caaagtaatt tcgccaagta atttatcatc tttcattaaa gctacagttg caactttaga
     5041 agaggaatct acagctaata caatcatatt gtcagctcct ttatataatt atatctttct
     5101 ccataaggag ttaatattat ttttctgtaa tcttcacctt tagcaagatc tttttctata
     5161 tatatatgaa gtaaatcttt aggtagaatt tcttctatat aatttgccca ttctataaca
     5221 gatacagcat ctgaaaatat gtaatcatca aatccaatag cataaacttc atcaggatca
     5281 cttactctat aaacatcgaa gtgatttaat tttaaacgtc cactatcata ttcatttaca
     5341 atagtaaaag ttggacttgt aatagtctca tctataccta agccttttgc tattcctttt
     5401 gtaatgtggg ttttaccagt gcctaaatct ccagttaaac agattatatc accagcattt
     5461 aataactttc ctaattttat tcctaattga gtagtttcag ctacactatt aatttcaaat
     5521 ttcatggaat acctccttca aacttttaaa gagaatgaat gtaagataat tttaggcaca
     5581 ttttgattgt accttatata aaatttctca ttcttttatt ttatatcaaa ttttcataaa
     5641 agcaaattaa taaatgttat tattgattta tttatcaaag ctagatagaa atctatagtc
     5701 cagttgtata acaacccaaa aaaagaataa agaataaagt ttatttcagt aagttgtatg
     5761 ataaatctaa aattgggatt tatttatcta taacaacttt acgaaataga atttatgatg
     5821 atttttagaa tattcaattg cagtttaaag ctacataaaa ttgtaataaa tttatatata
     5881 tttatttgta attagttggt ataatagatg taaatgcata ttagaattaa aatgatagat
     5941 aattaattta catgaatgtt gacttaaatt gattttttcg ataaaatttg gatgcacata
     6001 aagtgaatta ataaatagta taaggttaaa ataagtatat aaatgaacgt gacagataaa
     6061 taataaatgt aagattgatt aacgtgaaaa taaagttttt atgaaaagta atctgatttt
     6121 ttcgggggtg acttattttg aagaagatta catttgctat ggtattaata actatagtat
     6181 tgtctttagg aatgagtgta ttttcaagtc ctttgctagc aaatactgag aataaaagta
     6241 atgctgaaat gagagataaa tatttaaata taatgactgt gaataagccg caatatgata
     6301 tggtaaagaa aattataaag gacaagcaca acgttcaata tatgtttact gatgaaaagg
     6361 aaatcagtga atttaaatat aatgcaagtg ttttggaaaa cgtatcaaat atggatttat
     6421 ttatatattc tggagctact tttgaacctt gggctaattc atttattagt gaattgacaa
     6481 aaggaaatct aggaataatt aatttatcca gaggagtaag acttttaaat tatgatgaag
     6541 gtgcaactaa ggaaaatcct tattactttg agggtataga cgaatataaa atagcgttat
     6601 gcaatgtaaa ggcagctatt gaagatagag atcctaaaaa tagagatttt tatgaaaaga
     6661 attataatat tgcaattaaa gaatttaatg ataaattaaa atcttatgat gataagataa
     6721 aatcgcttag tgactataca tttataacat taaatcatga ttttgattat ttgactaaat
     6781 ccttgaactt aaatattaaa gaacttaata atcatgaact gggtgaattt ataaaaagca
     6841 ataatttaga tcctaaaaaa gttattgtta tagtagatgg agaacaagat ccaaaaataa
     6901 atttgtctgg atataataca ataaagttat ggaaatatta tggagattgg tcttttgatg
     6961 acttgatttt atataacata gatgaattag caaaatgggc aaaaccagca gataagagtt
     7021 caactggaag cgtggcataa taattgttaa ttataatatg tattaaaaat taaattatat
     7081 gtaataataa tatataggtt ataagattca acaagttttt taaaaaaaat aaaaaaactt
     7141 gttgatttat ttaaaattat attatataat cgtttatgtc gtgaaggggt atggctcaac
     7201 ggtagagtag tggtctccaa aaccattggt tctgggttca aatcctagtg cccctgccat
     7261 aattgtcgta gcacagtgtg ttacggcttt tttttattta aaaaaactag ttatttatta
     7321 aattggttta tacatatatt cttcagaatc gatcatagcc atatactagt caatactatt
     7381 ttgtgatcag caataagggg caaacttttt tgagaaaaga gaaagtttgc cttttttgtg
     7441 ttttagcaaa ataaataatt ttagaagata aataatattt gaattaaaaa acatatagct
     7501 atatgaaata actaatagtt aatttttaaa gtgaagataa tgaaaaatac gtagaaataa
     7561 gtatgtaaat aataaaagta ataaaaataa taactctttt tttcaattaa attgtataat
     7621 atgtaataat attgtattat agaaatagat gggagtgatg ttttttgtat tctgttattt
     7681 tagtagaaga taatattgag gaaagaaata ttttaaaaaa aatgcttctt tcaatatctg
     7741 aatttataaa aatatatgag gccgatagtg aagcaacagc tttaaatata attcaaaata
     7801 atgacattaa tatgttttta atagacatta acctaaaaca atcttcagga ttagatcttg
     7861 cgatgaaaat tagaagtata tctaaatatg aatttaggca aatcattttt ctaacaactc
     7921 atatggcata tattacacaa gcatttaaga aaacacattg ctatgattac atattaaaac
     7981 catatgatca taaagaggta caagttatgt taaataagct tatacttaat gagagcagtt
     8041 ataaagataa agtagaagag aaagaattag ttataacttt gaaaagtggt atatatgtag
     8101 gaattaaaat aagggagatt atttttatag aggttatagg taagaattgt gaagtaaata
     8161 ctattaatgg tttgtatatt gctaataata tgagtctaaa gaagattatg aaattaattg
     8221 attgtgacga tattatccaa agtcatagat cttttgcggt aaataaggat tacatatcta
     8281 aaatagaaaa gattgatatt aaattaagtg cggtgtattt taataattct tctaaaactg
     8341 cacttttagg atataaattt aagaataatg taatagatga attcaaaaaa ggaaaagtga
     8401 tattatgcta ggcaatttta ttatggatgc tttagataca acaattgtat tttgtttatg
     8461 gaaaacaata aataataaaa gtaaagttaa tgtatttaaa cagttgttag ctatacttat
     8521 tattgctagt ttagttgcag caattgaaca attaaaactt aattttatat taatatatat
     8581 agtgtatatt acagtattaa aaattatata taactcaaat ttaatagaat gtgtattaat
     8641 atattttttt ataatgcttg tagatatggc tctgcaacta acatttacaa taattattag
     8701 accatttatt acgaactata cacttaaagg aattgttata gaagtaataa tattagttat
     8761 ttccattatt tttttaaagc taaataaaaa taggaaaatt acatttgaaa aaataaataa
     8821 taatattttg gtttatttag cttcaacttg tattatatat actatgttat ttaaaattat
     8881 ttgggaatat gattctaata taattttaaa taacatgttt attgtagcag ttatttggat
     8941 tatactgata ttttgtcaaa cgttaacata ttttcatatt attgaaataa caaaagaaac
     9001 agaaaagtta aaaatatcta atgaatataa tgttgctata aatgaaatag ttcaagaaat
     9061 aaaacaaaga caacatgatt tcgttaatta taaaaataca ataaaaggta tgatggaagt
     9121 tttagatgaa aaagaactga gggaagcaat ttataattat atgaaagatg aggatgaata
     9181 tgattataag ataaatgaac ttatatatat tgataatgca gttattaaat ctatattata
     9241 tagaaatatg tgtaaagcta aaaaatataa tgttaatctg caatataaaa tagaaaataa
     9301 tgttttggat gatatattga gttatcagga attgtctaat atattaaata atttattgaa
     9361 taatgctttt gacgaggtaa taaaagaaga atgtattaat aaaaatatta aattagaaat
     9421 tgttaataga aataaagaat ctcatttaat aattaaaaat caaatagcta atgttaatga
     9481 tcttaattta aatgagatgt ttgaaagagg tttttcaact aaaaatatag gtaccagagg
     9541 ttatgggtta tataatgtaa aaaaaataat taatttacat aaaggtttta taaaggtaaa
     9601 tatagaatcc ggaaaaatta aatttgattt ttattttaat aattcttcag gataatctgg
     9661 ttcaccatac ataccaccac aacttgattt tgatactaga ttaaataaat taagtagtat
     9721 ggctgaaaaa atatttatag atttttgcat ttcgaacaac tccttttata ttaacgataa
     9781 ttaattgaat gatttgtatt aatatactta aaaatataca attatatatt ttagaatctg
     9841 atagtttaaa aaataatata gaccaaaatg taagcgatat taaagataat atctttaatg
     9901 tcgttttatt ttttattggt cttttttcat ttttacaagg agcataagtt aatgtaataa
     9961 tgaatgatat tataaaaaaa actatataaa aattaatatt taattgtata gctgatttac
    10021 taaatagtaa tattgataaa aagtaaattg tacttacaat taaacatgaa gtataagttt
    10081 tacaatgaat acctccccct aatgttcttg ttgaaattaa aataacaaaa atcaagaaaa
    10141 aaagtggtat ttcattaaaa aacaaaaata ttatgaatat aagtgataat ttacttatat
    10201 ctcctaaaat cacttctaaa gtatactgca tttttagtaa atctgttttt gttaaagaac
    10261 tattattttt ttttaaatgt ttacatatta aagttgaaaa actttttatc attttaacct
    10321 ctttcataat attttatatt gtataaaaat actatatatt aaaacaaaat tcaatagaaa
    10381 tgacataaaa cgcaaaaata taggaataaa aagaaataat aagttaataa agatagtcat
    10441 taagattata tttgccatat aaactatcaa aattaattta gaaaagtact agagctgtct
    10501 ataatataaa aatgaacatt caaaaaataa tctaaataat ttaattttgt agttcgtgct
    10561 ataatatacg tgaaatgtaa atatatataa aacacaagtt atgagagagg cggtattgta
    10621 atgggaattt ttaatggact ttaatagtct atgtgtaaga gtgagtatta aatctccagt
    10681 atagactata cagaaaattt ataatgttta ttattactgg gaggtaagaa atgtcttatt
    10741 ttaaatatca aaattttgat atttattaca aagtatatgg tgaaggaaaa cctttagtta
    10801 tcatacatgg ggatacagct tcttcaaaaa tgtttatacc agaattaaaa ttctattcta
    10861 aaaatttcaa ggtgattttg ctagatttag taggacaggg aaaatctaaa agagtagatg
    10921 aattaccttt aaattattgg cattttaatg caatggtagt tattgggtta tgcaaatata
    10981 taggtgttaa caatgttaat ttattaggta caagcggtgg tgctattgtt gcgttaaatg
    11041 cagcattaga gaattcaaac ttattcaata aaataattat agatagcttt atgggagaaa
    11101 atttacctta tgagtttgct gaaaaaattt tagttgatag aaaaatagca aaaaataagt
    11161 taagctcaaa gttattttgg tttatgatgc atggttttga ttggaaatat gttattgatc
    11221 aaaatacaaa tttaattatg aactttgcaa gagaaaaagg tgattttttc gagtgtaatc
    11281 ttaataatat aaaaaatgat atattaatta caggaagttt gaaggatgat ttaataccta
    11341 atattgaaaa tatattaaaa aacattaatt cgaaaataga aaattctaaa ttagttattt
    11401 ttaagtatgg aaatcatcca gctatgttta gcaataaaaa agaatttaga aatttagtgt
    11461 tgaatttttt gatgtaaatt attcatttaa aactactcat ttattaaact agaagattta
    11521 gtgataaagt catatctagt tttagcttct ataacgctta tgattgcttt agtaaaatca
    11581 tagataatta aattatatgt acaaaattgc gttgaaataa atatttagtg atatatttat
    11641 aattaaatta aatgataaaa tatacttttt attcttaatt atacatggtg aaaaatgtat
    11701 ttacttaatt tagaaaaagt gtaactatat aattacaagt atagttacac tttttctaaa
    11761 ttataataag aagttatagg tagggtaaat gtttattaca atattatcga ttgattatta
    11821 aagttatagc aatgtaattt aataaaaagg atagatgtta ttatataaat ttttatatct
    11881 aataattttt taaatgtaat tctattattg taacatatat agaaaaggga ggaattatgt
    11941 tagtcttaaa agtaaaaaaa ttaaaaaaaa cttataaaaa taatacaaat aaaactaatg
    12001 cacttaatgg tattgatttt acagtaggac aaggtgaatt tgttggtata atgggaccat
    12061 cagggagtgg taaaactact ttattaaatg tacttagtgg aatatcaaaa ccgacagctg
    12121 gggaaattga aattttagga caaagtgtaa aagatatgtc taagcatgaa atgacattat
    12181 ttagacgtaa gcatttggga tttgtatttc aagattttaa tttattagat agtttaacgc
    12241 tagaagaaaa tattatgttg ccattaagct tggaatcata tgaatcagag gaaaggtata
    12301 aaaaagtaaa taaagttatg actatgttta atatagttaa tgttaaacat aaatatcctt
    12361 atttggtttc aggtgggcag caacaaagag cagctattgg tagagctata attaataaac
    12421 ctgatattat atttgcggat gagccaactg gtaatttaga ttggaagtct tccaatattg
    12481 taatgaatta ttttgaaaga ttgaatctag aaaataaaaa tacaatatta gttgtaacgc
    12541 atgatccatt tactgcgagc tattgtaaaa gaataatttt tattaaggat ggattaattc
    12601 attcagagat tactaacaat gataatgata agcaaatatt ttttgataaa atattagaaa
    12661 atctcaataa tattggagat gaaaaagatg acctttaagg aactttcaat aagaatgttt
    12721 aaatcaaata taagaaggta tacactttat tttgcatgta gtggatttat tactatggtg
    12781 ctttttttat acttaacttt gtatacaaat aaagatttta acaatcccta taaagtagat
    12841 agttcgattt caggaaatct ctttgcccct acattagttc tatttatatt tgccacttgt
    12901 ttcataattt atgcacataa ttattttatt aaatttagaa aaaaggattt tgcgctcttt
    12961 atgataatag ggatgactga aaatgatata agaaaaatta tattattaga aaatataata
    13021 attgctatta tatctgtttt agttggactt tttttaggaa catgtttgtc aaaggtattt
    13081 tattttgttg tatctcaatt agcaaatttg aaaatagatt tttcaataaa tttaaagagt
    13141 tatttatata caatagtatt tttaagtttg gtaaatttaa taatgatatt aaaaagttgt
    13201 atatttattc cactttatca aattataaat ttattaaagg ctcaacataa agctgataac
    13261 aatttttctg gaaatccttt ctttggagtt ttgggcgtga tttttatgtt aattccatat
    13321 attcgcgtgt ttgataatag attttcattt tcattttttg cagttatatt aataaattta
    13381 attggattat atttgttaat ttctaattta cattggttta ttaaaaaatt ctttaaatca
    13441 aactcttttg ataatttaat ctggataaat aatttaaaat attcaatagg aaattctaaa
    13501 aaaattattt tttcaataac tgcacttatt gcttcgatac tttattttat aagttttagt
    13561 tattcagcta atgaatccat taacaacaat attataatac aaaacccata tgatttagct
    13621 tatgcagaaa tatatggaaa aaatgaaata tcggaggata cattaaataa cacacttaaa
    13681 agtaatgatg taaaggtaga atcaataaat agcttagaaa ttgttgtaca agggtctaca
    13741 gtaatgatat cagataaatc attaaataat ttacttggaa gcaattttaa tgtagaaagg
    13801 ggcaagtata tttgtttact tcaaataaat agaaatgatg gttatgttca taatgaacaa
    13861 gaaattgaaa attataccat aaataataca acatatattt tacaagaaaa attagaaaaa
    13921 atattattta ataagattcc aatattaaat aattcacatt atttaatatt taatcaggat
    13981 gactataaag aaataaaatc ttcagtaaaa tcaaaatata taggaaatgt taagttcata
    14041 aattttaatg attggactaa aactgaaact gtagtgaata atttaacgga tgaattagaa
    14101 aattacaaca aaataaatac aaaacaattt tttggcagta ccaatgatga cagaagacaa
    14161 tttaagccag tttcaaaaat tattgattac aaattattaa aagaatctag tcaattttta
    14221 acctttttat tatgctttgt atttatttta ttttttattt cttcaaattt aataatacat
    14281 tttaagcttt taactgaatt tgataacgaa aaaattaaat acgaaaaact taataaaata
    14341 ggggttttag aaaaagaaat ttcatcaaat atttcaaaag agttaagcat aattttttta
    14401 ctcccatgca ttttaggtac gtacctagga acttattgta tatactcaaa gatagcttca
    14461 attggaatta gcaatttaca tgaaatacga tatgcattga ttacaggtgt tgcttataca
    14521 gtattagaat taatatttta tttgttttat aaaaagcatt atataaattt gttgttaaaa
    14581 tgacagaaga actatattca aaactaaata tttattttaa agtctatgag ataaagctat
    14641 aatagtataa aattacacta ttatagcttt aaatataatt aataaactaa tacgcaaatg
    14701 gagaagacaa tgaaaaaaat agatttaact gaaggaaaag taataaatgt tataacagct
    14761 ttagctttgc ctataatggg aagttcatta ttacaattca cttataactt ggttgatatg
    14821 ttatgggtag gtggattagg cagcaatgca gttgcaagta ttggatcttc aagtctttat
    14881 ataggacttg gatactcaat aaattcttta gtcgttattg gtgctggcat aaaagtagct
    14941 caggggattg gaagaaagga taataatcaa gttaaggaat atattaatgc aggaattttt
    15001 attaatttat tgatgggatt aattttgggg tctgcattga tttttgtagg aaaagaactt
    15061 ataggatttt tacatatcga aaatgttgtt gttgaaagag atgcttatta ttatttggct
    15121 ttaaatggtc caattttatt ttttacattt tttaatactc tttatgcaag gatattgggg
    15181 agctttggaa ataataaatt agcacttaaa attaatgctt tgggtttagc gttaaatata
    15241 atacttgatc caatgtttat ttacactttt aaatttggag ttttaggagc ggctatttcg
    15301 acgttaattg ctaatataat tatgtttatt gtatatttag taaagtcttc tggaatactt
    15361 aaatttaatt ttcaagctgg aatagataaa aataagataa taaaaataat aagacttggt
    15421 ttgcctatgg tatttcaaag aattttattt acaataatta atattatgct agcgaaaatt
    15481 gtagcttctt ttggctcaga tgcaatagca ggtcaaaaaa tagggcttga aattgaatcg
    15541 gttatgtata tggttgttgg tggattaaat ggggcagttt caagttttac tgggcaaaat
    15601 tttggagcta agaaatttaa tagaataaaa gaaggatata atggagctct taagattgga
    15661 ataatatatt cattaataat tgcactagca tttttgttct taaataaacc gctaattaga
    15721 ctatttatta gagaagaaaa cacaattatg attgcagcag catatttaca aatggtagct
    15781 ttttcgcagg tatttagtac attagaaatg gtttcaaatg gtttattcac aggtataggt
    15841 aagcctaata tacctgctac tataagtgtg gtattcactg ctttaagaat tccaatgtca
    15901 ttaatattaa taaaaccatt tggagtaaat ggcatttgga taagcattgc gttatcaagc
    15961 attttaaaag gaagttttgc ttatttatta tattgtgtta aagttaagag aaaatataaa
    16021 gaagtaaaaa tatagaatat atatatgttg taagaatgat tagaagggac tatgctaaac
    16081 aaatgattat gaaactatta aaaatttgat aaaataataa aagatgaata gagttgaaat
    16141 gtaaagtaaa ggatttaaat atgcaataat tgcgctatta gtatagagga ggaacattat
    16201 ggaggaatta acaattgctt tgttgataga tgcagataat attggtgcta aacatattga
    16261 gaatatatta ggtgaactca caaagtatgg aagggttaca attcggagaa tgtatggtga
    16321 ttggactcag gaaaggttaa aatcttggtt agaaaaatct tctcaatttt cacttactcc
    16381 tataatgcaa tccaatgata cttcaagaaa gaatgcttca gatataggtc ttgttattga
    16441 tgcaatggat atattgtatt cagagaaggt aaatggtttt tgcattgtat caagtgattc
    16501 ggattttaat aaactggcaa aaagattacg cgaatctgga aatttagtaa ttggtatggg
    16561 agaacaaaaa actccagaat catttagagc ttcctgtgaa aaatttattt atttagatat
    16621 catagatgaa gatatagaac ttgaagatga gaaattagat atagaggttg gcaataatga
    16681 aagtagtaaa aaatattttg aagaaaaatc atttacgaaa aaaagtataa tagaaaagac
    16741 tattattaat atgattttag acagtactat ggatactatg catcttggag aaatagggca
    16801 aaggataaat aatatgtttc ctgattttga tgtgagaaat tatcattata caaaattatc
    16861 tgaattgcta aaggagtttg atagtcttac tttaagtaat aaagaaaaca agtactgggt
    16921 tgctctgaaa aatattatgc cggaaaatat taaagaaatt gaaaataaaa tagttgtaat
    16981 atttaataag aaacgagtat caaagatgaa cattggagaa ttaaaaaaag aattatcgag
    17041 cgttattcct aatttaaata tagttattaa aaaaagtgga gtcactaagt tttctgtatt
    17101 tttagataaa aaaattgata ttattacaat tagtgatgat aataacaatg ctgaacttat
    17161 taaataagct gatatattag tatagatgat agataaatta atatgaagta tagttttaac
    17221 ctaagtgaaa tttagtgagt tggaaaatta tttttaagag tacattcatg gaataatgat
    17281 ttgattttgg ctataatata attaatattg catcaaaggg gaaattttat gtttaatgaa
    17341 aataaaatga atagttcaaa agataaaact cttatcttaa gtattgttaa tagccaatgt
    17401 tttaaagacc tatttataaa tagaggcata actaatgtta ttatttttgg tagtttagca
    17461 aatggagatt ttacaccaga atctgatgtg gacattgcaa ttatttcaaa aacccctata
    17521 tcatttaatg atgaattaat actaactcaa aaattagaag aactcttaga tagagatata
    17581 gatttaatcg atataaatga tgaaaatata aataatctta taaagattag tgcattaaat
    17641 agtaagtttg ttgttttaaa agactatctt ttggatgaga ctataatctt ttacgataat
    17701 ttatataaag ataatgaaga attttggaga atattagatc aggaggtact tggaattgaa
    17761 taaagaacgc ttgaaaaagt tattatatga tttagataca accacaaaag atttaaataa
    17821 atcattacag ctagttaaaa aatatagtga taattcagag ttgaaatcag aattctcaaa
    17881 tagccttaaa tataaatatt taaggctatt tataatatat gaggatttta tatcaatgct
    17941 ttcaaaagaa tataatcagt atgaaatagg aatgacaatt gataaagcgg catttgattt
    18001 aaacttatat aaaaagaata taaagtgatg ctaaggaata taaattatat gttatttata
    18061 ttccttaaca tcactttata aatttaatta actaattgca ttgattgcat ccagttaatt
    18121 ttccactttc ctctattgaa ccactattaa ctactttact tcttagcaaa gttctacaat
    18181 tttttgtttt gtgataatgt ttcccttgag gagtccaata cacaatttct tcatttttaa
    18241 tttcttgaat actattttct tcaaacagtt ctaaagattt tgaattagag ttttcctgta
    18301 attcatttat tgaattttcg ttgtcgagtt taataagatt aagttcatca ctattagaat
    18361 tttcgtgatc atggtcttct aatatttgtt cttctaagtt tgtactggta tctttaaata
    18421 ggcctaatgg caaaacatcg acgattgtta ctactacttt acgttttaaa attcccatgt
    18481 aataaagtaa aaatataaat ccaattagta ctgttaggaa aagtaatatt attaaacctt
    18541 cttttaacat ttgtttttct ccttacatta atacgtactt gcgcacaatc aaaaatgtgt
    18601 tttatcttca attctatatt atatttgatt ttactaaaag taaaaaggct attgagaaaa
    18661 actatttaag aaattttaaa aaactattta agaaatttta aaaaactatt tacaacggat
    18721 aattattatt atataataat aaatgtacta aggaagaaat taacatggat aaataaataa
    18781 aaataaaaat aaataaattt agaagtttta ggaggaaaat attatgaaaa aattcgtttg
    18841 tacagtgtgt ggttatattt atgaaggaga agcagctcca gaaaaatgtc cagtgtgtgg
    18901 agttggagca gataagttta tagaacaaag tggagattta gcttttgctg atgaacatgt
    18961 aattggagta gctaatggtg tagataaaga aataattgaa ggattacaag caaattttgc
    19021 tggagaatgt acagaagttg gtatgtattt agcaatgtca agacaagcag atagagaagg
    19081 atatcctgaa gttgctgaag cttataaaag aatagcgttt gaagaagcag aacatgcagc
    19141 aaaatttgct gaaatgttag gtgaagtagt agttgcagat acaaaggcta atttagaagc
    19201 tagagtaaat gctgaacatg gtgcttgcca aggtaaaaag gatttagcta ctttagctaa
    19261 gaaattaaat ttagatgcaa ttcatgatac agtacatgaa atgtgcaaag atgaagctag
    19321 acatggaaaa gcattcaagg gattattaga tagatatttt gcatag
//
