Select genomic region:
Overview
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### Identified secondary metabolite regions using strictness 'relaxed'

NC_022571.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | RiPP-like | 136,568 | 145,120 |
Region 2 | RiPP-like | 282,374 | 293,336 | circularin A | RiPP:Head-to-tailcyclized peptide | 25%
Region 3 | cyclic-lactone-autoinducer | 588,142 | 607,507 | circularin A | RiPP:Head-to-tailcyclized peptide | 25%
Region 4 | NRPS | 895,649 | 942,243 | molybdenum cofactor | Other | 17%
Region 5 | cyclic-lactone-autoinducer | 953,196 | 973,395 | polysaccharide B | Saccharide | 6%
Region 6 | RiPP-like,NRPS | 1,064,579 | 1,117,343 |
Region 7 | NRPS | 1,860,295 | 1,912,620 |
Region 8 | lassopeptide | 3,174,348 | 3,197,820 | S-layer glycan | Saccharide | 26%
Region 9 | ranthipeptide | 4,052,237 | 4,072,905 |
Region 10 | NRPS,RiPP-like | 4,120,206 | 4,173,930 |
Region 11 | ranthipeptide | 4,279,377 | 4,300,934 |
Region 12 | cyclic-lactone-autoinducer,lanthipeptide-class-ii | 4,985,845 | 5,015,408 |

NC_022571.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 136,568 - 145,120 nt. (total: 8,553 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.24 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  | 0.22 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.22 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.21 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.21 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000484.1 |  | 0.20 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000554.1 |  | 0.20 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  | 0.20 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.20 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.19 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.58 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  | 0.55 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.55 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.54 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.54 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000484.1 |  | 0.53 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000554.1 |  | 0.53 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  | 0.52 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.52 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.52 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022571.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 282,374 - 293,336 nt. (total: 10,963 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.24 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000554.1 |  | 0.22 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  | 0.20 | RiPP | coagulin | Bacillus coagulans
BGC0000624.1 |  | 0.17 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001862.1 |  | 0.16 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.16 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001210.1 |  | 0.16 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001861.1 |  | 0.16 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000513.1 |  | 0.16 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.57 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000554.1 |  | 0.55 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  | 0.52 | RiPP | coagulin | Bacillus coagulans
BGC0000624.1 |  | 0.48 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001862.1 |  | 0.47 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.47 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001210.1 |  | 0.47 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000501.1 |  | 0.46 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001861.1 |  | 0.46 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000513.1 |  | 0.46 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022571.1 - Region 3 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 588,142 - 607,507 nt. (total: 19,366 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000548.1 |  | 0.18 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000487.1 |  | 0.17 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000488.1 |  | 0.16 | RiPP | circularin A | Clostridium beijerinckii
BGC0000521.1 |  | 0.16 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000539.1 |  | 0.16 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000626.1 |  | 0.15 | RiPP | thuricin | Bacillus thuringiensis
BGC0001210.1 |  | 0.15 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000489.1 |  | 0.15 | RiPP | enterocin AS-48 | Enterococcus faecalis
BGC0001222.1 |  | 0.15 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000916.1 |  | 0.14 | Other | molybdenum cofactor | Staphylococcus carnosus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000548.1 |  | 0.49 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000487.1 |  | 0.49 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000488.1 |  | 0.47 | RiPP | circularin A | Clostridium beijerinckii
BGC0000521.1 |  | 0.46 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000539.1 |  | 0.46 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000626.1 |  | 0.46 | RiPP | thuricin | Bacillus thuringiensis
BGC0001210.1 |  | 0.46 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000489.1 |  | 0.45 | RiPP | enterocin AS-48 | Enterococcus faecalis
BGC0001222.1 |  | 0.45 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000916.1 |  | 0.43 | Other | molybdenum cofactor | Staphylococcus carnosus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022571.1 - Region 4 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 895,649 - 942,243 nt. (total: 46,595 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001686.1 |  | 0.28 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000308.1 |  | 0.27 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000313.1 |  | 0.25 | NRP | beauvericin | Beauveria bassiana
BGC0001132.1 |  | 0.24 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  | 0.23 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.1 |  | 0.23 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001135.1 |  | 0.23 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.23 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001131.1 |  | 0.23 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001844.1 |  | 0.23 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001686.1 |  | 0.62 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000308.1 |  | 0.60 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000313.1 |  | 0.59 | NRP | beauvericin | Beauveria bassiana
BGC0001132.1 |  | 0.57 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  | 0.57 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.1 |  | 0.57 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001135.1 |  | 0.56 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.56 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001131.1 |  | 0.56 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001844.1 |  | 0.56 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 895648 - 942243:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_762: X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (465..863): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFlVgAViK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1504..1902): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFlVgAViK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)

NC_022571.1 - Region 5 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 953,196 - 973,395 nt. (total: 20,200 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000486.1 |  | 0.17 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001222.1 |  | 0.16 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.16 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000616.1 |  | 0.16 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001743.1 |  | 0.16 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0001411.1 |  | 0.15 | Saccharide | polysaccharide B | Bacteroides fragilis
BGC0000937.1 |  | 0.15 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0002036.1 |  | 0.15 | Other | dehydrofosmidomycin | Streptomyces lavendulae
BGC0000488.1 |  | 0.14 | RiPP | circularin A | Clostridium beijerinckii
BGC0001651.1 |  | 0.14 | Other | legionaminic acid | Tannerella forsythia 92A2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000486.1 |  | 0.48 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001222.1 |  | 0.47 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.47 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000616.1 |  | 0.46 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001743.1 |  | 0.46 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0001411.1 |  | 0.44 | Saccharide | polysaccharide B | Bacteroides fragilis
BGC0000937.1 |  | 0.44 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0002036.1 |  | 0.44 | Other | dehydrofosmidomycin | Streptomyces lavendulae
BGC0000488.1 |  | 0.44 | RiPP | circularin A | Clostridium beijerinckii
BGC0001651.1 |  | 0.44 | Other | legionaminic acid | Tannerella forsythia 92A2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022571.1 - Region 6 - NRPS,RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,064,579 - 1,117,343 nt. (total: 52,765 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000558.1 |  |  | 0.39 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  |  | 0.37 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  |  | 0.37 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001861.1 |  |  | 0.37 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0001863.1 |  |  | 0.37 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000554.1 |  |  | 0.36 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  |  | 0.35 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  |  | 0.35 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001210.1 |  |  | 0.32 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000521.1 |  |  | 0.32 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.68 | RiPP | coagulin | Bacillus coagulans
BGC0001399.1 |  | 0.64 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000624.1 |  | 0.59 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000619.1 |  | 0.59 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.59 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.59 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000558.1 |  | 0.57 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000410.1 |  | 0.55 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000427.1 |  | 0.55 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001825.1 |  | 0.54 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022571.1 - Region 7 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,860,295 - 1,912,620 nt. (total: 52,326 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000412.1 |  | 0.28 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000343.1 |  | 0.27 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001343.1 |  | 0.25 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001636.1 |  | 0.23 | NRP | KK-1 | Curvularia clavata
BGC0000935.1 |  | 0.22 | Other (Aminocoumarin), Polyketide | esmeraldin | Streptomyces antibioticus
BGC0000397.1 |  | 0.21 | NRP | nostocyclopeptide A2 | Nostoc sp. ATCC 53789
BGC0001502.1 |  | 0.21 | NRP | amonabactin P 750 | Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0000495.1 |  | 0.21 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0000400.1 |  | 0.21 | NRP | paenibacterin | Paenibacillus sp. OSY-SE
BGC0001699.1 |  | 0.21 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000412.1 |  | 0.61 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000343.1 |  | 0.60 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001343.1 |  | 0.58 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001636.1 |  | 0.56 | NRP | KK-1 | Curvularia clavata
BGC0000935.1 |  | 0.55 | Other (Aminocoumarin), Polyketide | esmeraldin | Streptomyces antibioticus
BGC0000397.1 |  | 0.54 | NRP | nostocyclopeptide A2 | Nostoc sp. ATCC 53789
BGC0001502.1 |  | 0.54 | NRP | amonabactin P 750 | Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0000495.1 |  | 0.54 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0000400.1 |  | 0.54 | NRP | paenibacterin | Paenibacillus sp. OSY-SE
BGC0001699.1 |  | 0.54 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 9, location 1860294 - 1912620:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Me-cys - cys) + (Me-cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1614: sal
  Search NORINE for peptide: strict or relaxed
  AMP-binding (29..434): sal
  NRPSPredictor2: sal
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      aLPgQGVICK
    Nearest Stachelhaus code:
      sal
    Stachelhaus code match:
      80% (moderate)
ctg1_1615: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (545..940): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNiSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (1970..2368): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNMSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_1616: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (534..924): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)

NC_022571.1 - Region 8 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,174,348 - 3,197,820 nt. (total: 23,473 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lasso peptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.1 |  | 0.24 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0000214.1 |  | 0.24 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0000581.1 |  | 0.21 | RiPP | microcin J25 | Escherichia coli
BGC0000796.1 |  | 0.19 | Saccharide | S-layer glycan | Paenibacillus alvei
BGC0000500.1 |  | 0.19 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.19 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001407.1 |  | 0.18 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000543.1 |  | 0.18 | RiPP | pep5 | Staphylococcus epidermidis
BGC0000813.1 |  | 0.18 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000724.1 |  | 0.17 | Saccharide | streptomycin | Streptomyces griseus subsp. griseus NBRC 13350

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.1 |  | 0.58 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0000214.1 |  | 0.58 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0000581.1 |  | 0.54 | RiPP | microcin J25 | Escherichia coli
BGC0000796.1 |  | 0.51 | Saccharide | S-layer glycan | Paenibacillus alvei
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.51 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001407.1 |  | 0.50 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000543.1 |  | 0.49 | RiPP | pep5 | Staphylococcus epidermidis
BGC0000813.1 |  | 0.49 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000724.1 |  | 0.49 | Saccharide | streptomycin | Streptomyces griseus subsp. griseus NBRC 13350

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.
Lassopeptides - No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
NC_022571.1 - Region 9 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,052,237 - 4,072,905 nt. (total: 20,669 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.1 |  | 0.19 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001733.1 |  | 0.19 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000504.1 |  | 0.19 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000486.1 |  | 0.16 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000487.1 |  | 0.16 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0001210.1 |  | 0.15 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001526.1 |  | 0.15 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001407.1 |  | 0.15 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000620.1 |  | 0.15 | RiPP | lacticin Q | Lactococcus lactis
BGC0001639.1 |  | 0.15 | RiPP | klebsidin | Klebsiella pneumoniae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001733.1 |  | 0.51 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000504.1 |  | 0.51 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000486.1 |  | 0.47 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000487.1 |  | 0.46 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0001210.1 |  | 0.46 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001526.1 |  | 0.46 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001407.1 |  | 0.46 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000620.1 |  | 0.46 | RiPP | lacticin Q | Lactococcus lactis
BGC0001639.1 |  | 0.46 | RiPP | klebsidin | Klebsiella pneumoniae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022571.1 - Region 10 - NRPS,RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,120,206 - 4,173,930 nt. (total: 53,725 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000426.1 |  |  | 0.38 | NRP | sevadicin | Paenibacillus larvae
BGC0000617.1 |  |  | 0.38 | RiPP | coagulin | Bacillus coagulans
BGC0001050.1 |  |  | 0.36 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000457.1 |  |  | 0.31 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000396.1 |  |  | 0.30 | NRP | nodularin | Nostoc sp. 73.1
BGC0001671.1 |  |  | 0.29 | NRP | monobactam | Agrobacterium tumefaciens
BGC0001562.1 |  |  | 0.28 | NRP | curacomycin | Streptomyces curacoi
BGC0000349.1 |  |  | 0.28 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338
BGC0001502.1 |  |  | 0.28 | NRP | amonabactin P 750 | Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0001479.1 |  |  | 0.28 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.1 |  | 0.71 | NRP | sevadicin | Paenibacillus larvae
BGC0001050.1 |  | 0.69 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000457.1 |  | 0.64 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000396.1 |  | 0.63 | NRP | nodularin | Nostoc sp. 73.1
BGC0001671.1 |  | 0.63 | NRP | monobactam | Agrobacterium tumefaciens
BGC0001562.1 |  | 0.62 | NRP | curacomycin | Streptomyces curacoi
BGC0000349.1 |  | 0.62 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338
BGC0001502.1 |  | 0.61 | NRP | amonabactin P 750 | Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0001479.1 |  | 0.61 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001767.1 |  | 0.60 | NRP | salinichelins | Salinispora pacifica CNY331

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 12, location 4120205 - 4173930:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys - D-cys) + (leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3659: leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (865..1138): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
ctg1_3660: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (484..908): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYdfSfIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1550..1974): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYdfSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      80% (moderate)

NC_022571.1 - Region 11 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,279,377 - 4,300,934 nt. (total: 21,558 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.1 |  | 0.15 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001122.1 |  | 0.12 | NRP, Polyketide | dihydroisoflavipucine, isoflavipucine | Aspergillus terreus NIH2624
BGC0000700.1 |  | 0.11 | Saccharide | istamycin | Streptomyces tenjimariensis
BGC0001686.1 |  | 0.10 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0001591.1 |  | 0.08 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.08 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001195.1 |  | 0.06 | NRP, Polyketide | nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D | Nocardiopsis sp. CMB-M0232
BGC0001281.1 |  | 0.06 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000464.1 |  | 0.05 | NRP | xenoamicin A, xenoamicin B | Xenorhabdus doucetiae
BGC0001159.1 |  | 0.05 | NRP, Polyketide | marinopyrrole A, marinopyrrole E, marinopyrrole D, marinopyrrole C, marinopyrrole B | Streptomyces sp. CNQ-418

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.1 |  | 0.44 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001122.1 |  | 0.39 | NRP, Polyketide | dihydroisoflavipucine, isoflavipucine | Aspergillus terreus NIH2624
BGC0000700.1 |  | 0.37 | Saccharide | istamycin | Streptomyces tenjimariensis
BGC0001686.1 |  | 0.35 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0001591.1 |  | 0.32 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.32 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001195.1 |  | 0.25 | NRP, Polyketide | nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D | Nocardiopsis sp. CMB-M0232
BGC0001281.1 |  | 0.24 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000464.1 |  | 0.24 | NRP | xenoamicin A, xenoamicin B | Xenorhabdus doucetiae
BGC0001159.1 |  | 0.22 | NRP, Polyketide | marinopyrrole A, marinopyrrole E, marinopyrrole D, marinopyrrole C, marinopyrrole B | Streptomyces sp. CNQ-418

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022571.1 - Region 12 - cyclic-lactone-autoinducer,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,985,845 - 5,015,408 nt. (total: 29,564 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001579.1 |  |  | 0.66 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000554.1 |  |  | 0.52 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000503.1 |  |  | 0.48 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000528.1 |  |  | 0.48 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000501.1 |  |  | 0.44 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000551.1 |  |  | 0.42 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000617.1 |  |  | 0.41 | RiPP | coagulin | Bacillus coagulans
BGC0000626.1 |  |  | 0.40 | RiPP | thuricin | Bacillus thuringiensis
BGC0001229.1 |  |  | 0.38 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000504.1 |  |  | 0.38 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.1 |  | 0.66 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000554.1 |  | 0.59 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000503.1 |  | 0.57 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000528.1 |  | 0.57 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000501.1 |  | 0.55 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000551.1 |  | 0.54 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000617.1 |  | 0.53 | RiPP | coagulin | Bacillus coagulans
BGC0000626.1 |  | 0.52 | RiPP | thuricin | Bacillus thuringiensis
BGC0000504.1 |  | 0.52 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001229.1 |  | 0.51 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg1_4309 - Putative Class II

ctg1_4301 leader / core peptide
  MKSMKENLFNKIAEKMACS - LGEADhaIKLDhaENAMEKC CFGGIYEDhbKIPIQLLKQNVNK
ctg1_4303 leader / core peptide
  MRETLLVVLMLLFVILAA - AMIFPMPPIIYGAIMDhaLIILCIIIIIDhaIYILIIKKNH

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_4301 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 4055.1 Da
  Molecular weight: 4057.7 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4075.8 Da N = 1
ctg1_4303 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 4158.5 Da
  Molecular weight: 4161.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4179.4 Da N = 1