GCF_000022905.1_ASM2290v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_012590.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NRPS-like	27,079	69,245
Region 1.2	terpene	2,306,954	2,327,745	carotenoid	Terpene	25%
Region 1.3	NAPAA	2,441,960	2,475,937	curacomycin	NRP	15%
Region 1.4	T1PKS	2,573,869	2,618,650

NC_010813.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	NRPS-like	1	29,037

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	NRPS-like	27,079	69,245
Region 1.2	terpene	2,306,954	2,327,745	carotenoid	Terpene	25%
Region 1.3	NAPAA	2,441,960	2,475,937	curacomycin	NRP	15%
Region 1.4	T1PKS	2,573,869	2,618,650
Region 2.1	NRPS-like	1	29,037

Compact view

NC_012590.1 - Region 1 - NRPS-like

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Location: 27,079 - 69,245 nt. (total: 42,167 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001527.1	0.28	Other	basidioferrin	Gelatoporia subvermispora
BGC0000328.1	0.27	NRP	coronatine	Pseudomonas savastanoi pv. glycinea
BGC0002002.1	0.23	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0000427.1	0.21	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001627.1	0.19	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001621.1	0.19	NRP	imizoquin A, imizoquin B, imizoquin C, imizoquin D, TMC-2A, TMC-2B	Aspergillus flavus NRRL3357
BGC0000843.1	0.19	Other (Non-NRP beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0001844.1	0.18	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001833.1	0.18	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001479.1	0.18	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001527.1	0.61	Other	basidioferrin	Gelatoporia subvermispora
BGC0000328.1	0.60	NRP	coronatine	Pseudomonas savastanoi pv. glycinea
BGC0002002.1	0.56	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0000427.1	0.54	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001627.1	0.52	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001621.1	0.51	NRP	imizoquin A, imizoquin B, imizoquin C, imizoquin D, TMC-2A, TMC-2B	Aspergillus flavus NRRL3357
BGC0000843.1	0.50	Other (Non-NRP beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0001844.1	0.50	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001833.1	0.49	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001479.1	0.49	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 27078 - 69245:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_46

Search NORINE for peptide: strict or relaxed

AMP-binding (42..419): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAESIGtViK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 80% (moderate)

NC_012590.1 - Region 2 - terpene

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Location: 2,306,954 - 2,327,745 nt. (total: 20,792 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.29	Terpene	carotenoid	Myxococcus xanthus
BGC0000650.1	0.27	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000634.1	0.20	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000643.1	0.20	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000640.1	0.19	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000656.1	0.18	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000633.1	0.18	Terpene	carotenoid	Streptomyces avermitilis
BGC0000637.1	0.18	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000664.1	0.18	Terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000644.1	0.17	Terpene	carotenoid	Dietzia sp. CQ4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.63	Terpene	carotenoid	Myxococcus xanthus
BGC0000650.1	0.60	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000634.1	0.53	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000643.1	0.53	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000640.1	0.51	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000656.1	0.50	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000633.1	0.50	Terpene	carotenoid	Streptomyces avermitilis
BGC0000637.1	0.50	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000664.1	0.50	Terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000644.1	0.48	Terpene	carotenoid	Dietzia sp. CQ4

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_012590.1 - Region 3 - NAPAA

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Location: 2,441,960 - 2,475,937 nt. (total: 33,978 nt) Show pHMM detection rules used

NAPAA: (AMP-binding and PP-binding and TIGR02353)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000375.1	0.21	NRP	indigoidine	Streptomyces chromofuscus
BGC0001399.1	0.21	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000427.1	0.21	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001758.1	0.18	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.18	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001641.1	0.18	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1	0.18	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.1	0.18	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1	0.18	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001131.1	0.18	NRP	ambactin	Xenorhabdus miraniensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000375.1	0.54	NRP	indigoidine	Streptomyces chromofuscus
BGC0001399.1	0.53	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000427.1	0.53	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001758.1	0.50	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.50	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001641.1	0.50	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1	0.50	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.1	0.50	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1	0.49	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001131.1	0.49	NRP	ambactin	Xenorhabdus miraniensis

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 2441959 - 2475937:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2344

Search NORINE for peptide: strict or relaxed

AMP-binding (49..436): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAESIGtVvK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 80% (moderate)

NC_012590.1 - Region 4 - T1PKS

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Location: 2,573,869 - 2,618,650 nt. (total: 44,782 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000044.1	0.22	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001163.1	0.21	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.21	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.21	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0000138.1	0.19	Polyketide	rimocidin	Streptomyces diastaticus
BGC0001264.1	0.19	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.19	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001276.1	0.19	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.19	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001998.1	0.19	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000044.1	0.54	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001163.1	0.54	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.54	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.54	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0000138.1	0.52	Polyketide	rimocidin	Streptomyces diastaticus
BGC0001264.1	0.51	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.51	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001276.1	0.51	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.51	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001998.1	0.51	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 2573868 - 2618650:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2454

PKS_AT (628..927): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: fatty_acid

Prediction, score:

fatty_acid: 102.8
Methoxymalonyl-CoA: 55.1
Methylmalonyl-CoA: 54.0
Malonyl-CoA: 39.4
Ethylmalonyl-CoA: 35.3
Acetyl-CoA: 29.5
Propionyl-CoA: 27.7
trans-1,2-CPDA: 23.0
Isobutyryl-CoA: 21.4
CHC-CoA: 16.9
2-Methylbutyryl-CoA: 8.6
inactive: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg1_2455

CAL_domain (66..533): pk

minowa: Acetyl-CoA

Prediction, score:

Acetyl-CoA: 24.7
NH2: 11.4
shikimic_acid: 7.8
AHBA: 7.1
fatty_acid: -1.8

NC_010813.1 - Region 1 - NRPS-like

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Location: 1 - 29,037 nt. (total: 29,037 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.1	0.28	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900.1	0.27	Other	ferrichrome	Aspergillus oryzae
BGC0000427.1	0.27	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001479.1	0.23	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000375.1	0.22	NRP	indigoidine	Streptomyces chromofuscus
BGC0001561.1	0.22	NRP	curacomycin	Streptomyces curacoi
BGC0001261.1	0.20	NRP	AM-toxin	Alternaria alternata
BGC0001132.1	0.20	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001517.1	0.20	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0000348.1	0.20	NRP	ergovaline	Epichloe festucae var. lolii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.1	0.61	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900.1	0.61	Other	ferrichrome	Aspergillus oryzae
BGC0000427.1	0.60	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001479.1	0.56	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000375.1	0.55	NRP	indigoidine	Streptomyces chromofuscus
BGC0001561.1	0.55	NRP	curacomycin	Streptomyces curacoi
BGC0001261.1	0.53	NRP	AM-toxin	Alternaria alternata
BGC0001132.1	0.53	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001517.1	0.53	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0000348.1	0.52	NRP	ergovaline	Epichloe festucae var. lolii

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 29037:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gln)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg2_26

Search NORINE for peptide: strict or relaxed

AMP-binding (47..406): gln

NRPSPredictor2: gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWQFGLInK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 90% (moderate)