LOCUS       c00006_NZ_CABK..       12364 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CABKVG010000006.1 Vitreoscilla massiliensis isolate
            MGYG-HGUT-01520, whole genome shotgun sequence.
ACCESSION   c00006_NZ_CABK..
VERSION     c00006_NZ_CABK..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:59:11
            Original ID  :: NZ_CABKVG010000006.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12364
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12364
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1614:2364](-)"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(1615..2364)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
     cand_cluster    1..12364
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="Autoind_synth"
                     /kind="single"
                     /product="hserlactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12364
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="hserlactone"
                     /region_number="1"
                     /rules="Autoind_synth"
                     /tool="antismash"
     CDS             complement(801..1571)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141:acyltransferase (Score: 60.4; E-value: 2.6e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_1"
                     /transl_table=11
                     /translation="MGRVGWHLLSGCTQIALFFGRSTPAQKQRRIQNWSAQLLGVCGMR
                     VQVVGDIAAIPKDTGRFWVSNHVSWLDIFAINAVQPMRFVGKDDIQTWPVIGWLVARSD
                     TIFISRSNRAAALAANDIISNALQAGANIAIFPEGTSTDGHQLKPFKHSLFQAPISAGV
                     PVQALCVRYPLPNGDLNPAPAYHGDISLWQTLVALLQQPQSVAEVHILAALDSTGMSRQ
                     QLGASAQSEIAQCLAQCAEQVVPIQAEYAETVTQ"
     PFAM_domain     complement(1065..1412)
                     /aSDomain="Acyltransferase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01553.23"
                     /description="Acyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_1_0001"
                     /evalue="4.30E-20"
                     /label="ctg6_1"
                     /locus_tag="ctg6_1"
                     /protein_end="169"
                     /protein_start="53"
                     /score="71.8"
                     /tool="antismash"
                     /translation="AIPKDTGRFWVSNHVSWLDIFAINAVQPMRFVGKDDIQTWPVIGW
                     LVARSDTIFISRSNRAAALAANDIISNALQAGANIAIFPEGTSTDGHQLKPFKHSLFQA
                     PISAGVPVQALC"
     CDS             complement(1615..2364)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hserlactone: Autoind_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_2"
                     /sec_met_domain="Autoind_synth (E-value: 1.3e-08, bitscore:
                     29.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQLQSQSHVHIQGGSLSVSLARSEFEIEEAQRLRYKVFAEEMGA
                     NIVSNNGLDVDKYDEHCQHLLVRERENDRIIGCYRLLTAEGAAAVGGWYSASEFDLSRL
                     QHILPHTVELGRACVHQDYRSGSTITLLWAGLMQFMQQQGLEYMIGCGSMCMKDGGHSA
                     ASMFRRLQEQCYAPPEYRVFPKNPLPIAALQQDLEVELPALIKGYVRAGAYICGEPHWD
                     TDFNSADVLVMMPISRINPRYARHFLK"
     PFAM_domain     complement(1963..2265)
                     /aSDomain="Acetyltransf_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13444.8"
                     /description="Acetyltransferase (GNAT) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_2_0002"
                     /evalue="2.10E-33"
                     /label="ctg6_2"
                     /locus_tag="ctg6_2"
                     /protein_end="134"
                     /protein_start="33"
                     /score="115.2"
                     /tool="antismash"
                     /translation="LRYKVFAEEMGANIVSNNGLDVDKYDEHCQHLLVRERENDRIIGC
                     YRLLTAEGAAAVGGWYSASEFDLSRLQHILPHTVELGRACVHQDYRSGSTITLLWA"
     CDS             complement(2578..3645)
                     /locus_tag="ctg6_3"
                     /transl_table=11
                     /translation="MSINMKNTDDVKIKEIKELLPPIAHLYELPLTEPASTLVHDTRAE
                     ISDLIHGKDQRLLVVVGPCSIHDPKAALEYAERLLPLKKKYEKELVIVMRVYFEKPRTT
                     IGWKGLINDPHLDGSFDINFGLRQARHLLLQLNNMGIPASTEFLDMITPQYYADLISWG
                     AIGARTTESQVHRELASGLSCPVGFKNGTDGNMKIAIDAIGAASNPHHFLSVTKSGHSA
                     IVRTAGNPDCHVILRGGSKNTNYDSESIQNAVAELSKAKVATKLMVDCSHANSRKKYEL
                     QMEVGRDVAEQIKAGESNLMGVMIESHLVEGRQDLVEGQPLCYGQSITDACIGWDDTEV
                     LLAELAEAVKTRIAA"
     aSDomain        complement(2590..3621)
                     /aSDomain="TIGR00034"
                     /aSTool="tigrfam"
                     /description="aroFGH: 3-deoxy-7-phosphoheptulonate
                     synthase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg6_3_0001"
                     /evalue="7.30E-166"
                     /identifier="TIGR00034"
                     /label="ctg6_3"
                     /locus_tag="ctg6_3"
                     /protein_end="352"
                     /protein_start="8"
                     /score="549.0"
                     /tool="antismash"
                     /translation="DDVKIKEIKELLPPIAHLYELPLTEPASTLVHDTRAEISDLIHGK
                     DQRLLVVVGPCSIHDPKAALEYAERLLPLKKKYEKELVIVMRVYFEKPRTTIGWKGLIN
                     DPHLDGSFDINFGLRQARHLLLQLNNMGIPASTEFLDMITPQYYADLISWGAIGARTTE
                     SQVHRELASGLSCPVGFKNGTDGNMKIAIDAIGAASNPHHFLSVTKSGHSAIVRTAGNP
                     DCHVILRGGSKNTNYDSESIQNAVAELSKAKVATKLMVDCSHANSRKKYELQMEVGRDV
                     AEQIKAGESNLMGVMIESHLVEGRQDLVEGQPLCYGQSITDACIGWDDTEVLLAELAEA
                     VKTR"
     PFAM_domain     complement(2623..3507)
                     /aSDomain="DAHP_synth_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00793.22"
                     /description="DAHP synthetase I family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_3_0003"
                     /evalue="2.00E-104"
                     /label="ctg6_3"
                     /locus_tag="ctg6_3"
                     /protein_end="341"
                     /protein_start="46"
                     /score="348.4"
                     /tool="antismash"
                     /translation="SDLIHGKDQRLLVVVGPCSIHDPKAALEYAERLLPLKKKYEKELV
                     IVMRVYFEKPRTTIGWKGLINDPHLDGSFDINFGLRQARHLLLQLNNMGIPASTEFLDM
                     ITPQYYADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNMKIAIDAIGAASNP
                     HHFLSVTKSGHSAIVRTAGNPDCHVILRGGSKNTNYDSESIQNAVAELSKAKVATKLMV
                     DCSHANSRKKYELQMEVGRDVAEQIKAGESNLMGVMIESHLVEGRQDLVEGQPLCYGQS
                     ITDACIGWDDTEVL"
     CDS             3959..4645
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 128.9; E-value:
                     3.6e-39)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_4"
                     /transl_table=11
                     /translation="MKAMILAAGRGERMRPLTDTTPKPLLPVGREPLIGWHLRRLQQAG
                     FTEVVINHAWLGQQIEDVLQDGRDYGVHIAYSPEGAQGLETAGGIATALPLLGDAPFLV
                     INGDVLTDIDFAQATRIAAQMATNNALAHLWLVNNPDHNPNGDFGLDGEHVVSHADTQY
                     TFSGCGVYHPALFQHTPAHQAAKLAPLLRTAMAEQQVTGHKHTGLWLDVGTVERLQQAN
                     ALMQHA"
     PFAM_domain     3962..4630
                     /aSDomain="NTP_transferase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00483.25"
                     /description="Nucleotidyl transferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_4_0004"
                     /evalue="5.00E-23"
                     /label="ctg6_4"
                     /locus_tag="ctg6_4"
                     /protein_end="224"
                     /protein_start="1"
                     /score="82.0"
                     /tool="antismash"
                     /translation="KAMILAAGRGERMRPLTDTTPKPLLPVGREPLIGWHLRRLQQAGF
                     TEVVINHAWLGQQIEDVLQDGRDYGVHIAYSPEGAQGLETAGGIATALPLLGDAPFLVI
                     NGDVLTDIDFAQATRIAAQMATNNALAHLWLVNNPDHNPNGDFGLDGEHVVSHADTQYT
                     FSGCGVYHPALFQHTPAHQAAKLAPLLRTAMAEQQVTGHKHTGLWLDVGTVERLQQANA
                     L"
     CDS             complement(4725..5492)
                     /locus_tag="ctg6_5"
                     /transl_table=11
                     /translation="MAVVLYDDGEHKCVAFSDLVTGEGVQSNQFAIVHKGDGMLLDPGG
                     NLTYKHLLAEISDYFLPSHTRYVFASHADPDIIASINGWLLITDANVLIAKEWERFIPH
                     FCLKGATTGRLTSIPAQGMKVELQGAELHLLPAHFLHPVGNFHVYDPISKILFSGDVGA
                     SLVDAETAGKPIDDFDHHLHNNGMLGFHKRYMSGNKACRYWVNMVRQLDVEWIVPQHGA
                     SFKGKEMVNRFLDWLEDLECGIDLLSQDDFKVL"
     PFAM_domain     complement(4833..5423)
                     /aSDomain="Lactamase_B"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00753.29"
                     /description="Metallo-beta-lactamase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_5_0005"
                     /evalue="9.40E-16"
                     /label="ctg6_5"
                     /locus_tag="ctg6_5"
                     /protein_end="220"
                     /protein_start="23"
                     /score="58.5"
                     /tool="antismash"
                     /translation="GVQSNQFAIVHKGDGMLLDPGGNLTYKHLLAEISDYFLPSHTRYV
                     FASHADPDIIASINGWLLITDANVLIAKEWERFIPHFCLKGATTGRLTSIPAQGMKVEL
                     QGAELHLLPAHFLHPVGNFHVYDPISKILFSGDVGASLVDAETAGKPIDDFDHHLHNNG
                     MLGFHKRYMSGNKACRYWVNMVRQLDVEWIVPQH"
     CDS             complement(5719..6489)
                     /locus_tag="ctg6_6"
                     /transl_table=11
                     /translation="MAVVLYDDGTHKCVVFTDLVTGEGVQANQFAISHNGEGVLLDPGG
                     NLTYKHLLAEISDYFLPSRTRYIFASHPDPDIIASVNGWLLITDAEVLIAEEWERFIPH
                     FCLKGATVGRMVTIPPQGMKLDLNGGELQIIPAHFLHPVGNFHIYDPISKILFSGDVGA
                     SIVDAEEAAQTVTDFDHHLHHNSMLGFHQRYMSGNKACRYWVNMVRQLDIEWIVPQHGA
                     SFKGKEMVNRFLDWFEELECGIDLITQDDFRLLK"
     PFAM_domain     complement(5830..6420)
                     /aSDomain="Lactamase_B"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00753.29"
                     /description="Metallo-beta-lactamase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_6_0006"
                     /evalue="4.80E-16"
                     /label="ctg6_6"
                     /locus_tag="ctg6_6"
                     /protein_end="220"
                     /protein_start="23"
                     /score="59.4"
                     /tool="antismash"
                     /translation="GVQANQFAISHNGEGVLLDPGGNLTYKHLLAEISDYFLPSRTRYI
                     FASHPDPDIIASVNGWLLITDAEVLIAEEWERFIPHFCLKGATVGRMVTIPPQGMKLDL
                     NGGELQIIPAHFLHPVGNFHIYDPISKILFSGDVGASIVDAEEAAQTVTDFDHHLHHNS
                     MLGFHQRYMSGNKACRYWVNMVRQLDIEWIVPQH"
     CDS             complement(6663..6986)
                     /locus_tag="ctg6_7"
                     /transl_table=11
                     /translation="MGLQVEDLSVGAGAEAVANKEVTVHYTGWLTDGTKFDSSLDRKQP
                     LTIVLGIGQVIKGWDQGIEGMKVGGKRKLTIPPELAYGNRAVGGVIPKNATLVFEVELL
                     SVA"
     PFAM_domain     complement(6675..6944)
                     /aSDomain="FKBP_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00254.30"
                     /description="FKBP-type peptidyl-prolyl cis-trans
                     isomerase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_7_0007"
                     /evalue="1.80E-36"
                     /label="ctg6_7"
                     /locus_tag="ctg6_7"
                     /protein_end="104"
                     /protein_start="14"
                     /score="124.4"
                     /tool="antismash"
                     /translation="EAVANKEVTVHYTGWLTDGTKFDSSLDRKQPLTIVLGIGQVIKGW
                     DQGIEGMKVGGKRKLTIPPELAYGNRAVGGVIPKNATLVFEVELL"
     CDS             complement(7048..7302)
                     /locus_tag="ctg6_8"
                     /transl_table=11
                     /translation="MIKTLTFAILHFSVAFSVAYALTGSIGISSTVALVEPIVNTVVFY
                     FHEKIWQGIEAKRRAKRGLQAALLADDKPKTLFGCGHSL"
     PFAM_domain     complement(7147..7302)
                     /aSDomain="DUF2061"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09834.11"
                     /description="Predicted membrane protein (DUF2061)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_8_0008"
                     /evalue="5.30E-22"
                     /label="ctg6_8"
                     /locus_tag="ctg6_8"
                     /protein_end="52"
                     /protein_start="0"
                     /score="78.2"
                     /tool="antismash"
                     /translation="MIKTLTFAILHFSVAFSVAYALTGSIGISSTVALVEPIVNTVVFY
                     FHEKIWQ"
     CDS             7419..8378
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 286.1; E-value: 3.9e-87)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_9"
                     /transl_table=11
                     /translation="MSSCHIVVLDRGTLMPLPWTFDFEHHLTEYDGTPDEEAINRCRDA
                     EIIITNKVKVDRATIEASPNLKMIAIAATGFEHVDLQAAAERGIIVSNIKAYGNDTVAE
                     HAFMLMMALMRQLPAYQRDVAAGLWQNSPYFCHFGAPIHDINGKTLLIFGKGGIGSALA
                     QRAEAFGMKVIYGEHKGAAVCREGYVPFAEALQQADVISLHCPLNAQTRNMLGEEELKT
                     LKPGCVIINVGRGGLVDETALIAALKYGGLGGAGFDVITNEPPTEGNPLVNTHLPHLIV
                     TPHMAWGSQEAMTRLFHMLIDNINQGMAGTPQSVVLPK"
     PFAM_domain     7737..8276
                     /aSDomain="2-Hacid_dh_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02826.21"
                     /description="D-isomer specific 2-hydroxyacid
                     dehydrogenase, NAD binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_9_0009"
                     /evalue="2.10E-52"
                     /label="ctg6_9"
                     /locus_tag="ctg6_9"
                     /protein_end="286"
                     /protein_start="106"
                     /score="177.1"
                     /tool="antismash"
                     /translation="FMLMMALMRQLPAYQRDVAAGLWQNSPYFCHFGAPIHDINGKTLL
                     IFGKGGIGSALAQRAEAFGMKVIYGEHKGAAVCREGYVPFAEALQQADVISLHCPLNAQ
                     TRNMLGEEELKTLKPGCVIINVGRGGLVDETALIAALKYGGLGGAGFDVITNEPPTEGN
                     PLVNTHLPHLIVTPHMA"
     CDS             complement(8473..9216)
                     /locus_tag="ctg6_10"
                     /transl_table=11
                     /translation="MKHVALWALCGSVWACAPADKPVIEAPERLLLPYSDVRYQGKVYV
                     ESVSQQGTHMLNLDCHTPTAQQWSPRAADVLAYMRAAVNKQTLPALQLDARVPPPLTVL
                     EQHTLQSVCQRRSVQESIDYPNHRRVTLLVDSIQILPEAVLPQTMTAWVVYERTPPAVS
                     DMFPKLAHDAHLVQVQMACREGQNASHVRRSMLLNQGVVWAWMGGFGGLIADDDPLRRA
                     VCRHYQVRPAQSDMQWRSEAYITQY"
     CDS             9467..9850
                     /locus_tag="ctg6_11"
                     /transl_table=11
                     /translation="MDDIHVRLANHPGTLAQFGQLLGQAGISLEGGGVFATGDSAEAHF
                     LVADGERAAQVLRAAGLHVIGQRAVLVRKLHQEQPGQLGKICARLAAHHINIHTMYSDH
                     HNRLILVVDDVAAAAAHTLEWQA"
     PFAM_domain     9476..9799
                     /aSDomain="ACT_8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19571.1"
                     /description="ACT domain pair"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_11_0010"
                     /evalue="4.20E-06"
                     /label="ctg6_11"
                     /locus_tag="ctg6_11"
                     /protein_end="111"
                     /protein_start="3"
                     /score="26.7"
                     /tool="antismash"
                     /translation="IHVRLANHPGTLAQFGQLLGQAGISLEGGGVFATGDSAEAHFLVA
                     DGERAAQVLRAAGLHVIGQRAVLVRKLHQEQPGQLGKICARLAAHHINIHTMYSDHHNR
                     LILV"
     CDS             9807..10535
                     /locus_tag="ctg6_12"
                     /transl_table=11
                     /translation="MWPPLPHTLLNGKPDMHSSDPAVHHVAELARVLAEPKRVLILLAL
                     MDGRAYTATELALMADIAPSTASSHLHKMREQGFIACVSQGKHRYFRLSSADIAQLLEQ
                     LLRFTALQKPSMVPSTPPHLRQARTCYQHLAGEIAVELAQEMVTAQWLQADSYDLTELG
                     HQALCRKGVPLAAWETYPQQQCTCLDWSERQFHIGKRLGSTLLRFFMQQGYFNTVAESR
                     ELVLTHKGKQHLLQQRFIQT"
     PFAM_domain     9912..10046
                     /aSDomain="HTH_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01022.22"
                     /description="Bacterial regulatory protein, arsR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_12_0011"
                     /evalue="1.40E-09"
                     /label="ctg6_12"
                     /locus_tag="ctg6_12"
                     /protein_end="80"
                     /protein_start="35"
                     /score="37.8"
                     /tool="antismash"
                     /translation="PKRVLILLALMDGRAYTATELALMADIAPSTASSHLHKMREQGFI
                     "
     CDS             10556..11389
                     /locus_tag="ctg6_13"
                     /transl_table=11
                     /translation="MQVVMASYSLCVATDTDTHPFFRPLWRHRKPLMSLIVALLLIFLL
                     AGMVKGVIGLGLPTIAMGLLTVFYPPATAASLLLIPSTVTNVWQLCLGAQLWPLCKRLW
                     PMLAGITIGTLWSVLPPLSSNNTWVHAGLGLILCLYALWGLLAKKLPSSARHERWLSPL
                     IGYVTGTITAATGVFVLPAVPYLQTLSLSKDELIQALGLSFTVSTLALAAQLLWQQGLP
                     NMNVGLSALAIVPAIVGMYVGQYLRQFISETVFKRCFFIGLLLLGGYMLLSDVLK"
     PFAM_domain     10670..11365
                     /aSDomain="TauE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01925.21"
                     /description="Sulfite exporter TauE/SafE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_13_0012"
                     /evalue="4.20E-30"
                     /label="ctg6_13"
                     /locus_tag="ctg6_13"
                     /protein_end="270"
                     /protein_start="38"
                     /score="105.2"
                     /tool="antismash"
                     /translation="LLLIFLLAGMVKGVIGLGLPTIAMGLLTVFYPPATAASLLLIPST
                     VTNVWQLCLGAQLWPLCKRLWPMLAGITIGTLWSVLPPLSSNNTWVHAGLGLILCLYAL
                     WGLLAKKLPSSARHERWLSPLIGYVTGTITAATGVFVLPAVPYLQTLSLSKDELIQALG
                     LSFTVSTLALAAQLLWQQGLPNMNVGLSALAIVPAIVGMYVGQYLRQFISETVFKRCFF
                     IGLLLLGGYM"
     CDS             complement(11472..11774)
                     /locus_tag="ctg6_14"
                     /transl_table=11
                     /translation="MKKIVTAIFATVLASFTAMSMAATVPSHQPMKHPVAAHQVKHVKK
                     VAVKNPTAQHRPAHKVVVKKHPSAKHHAQIKHAQAKKVAYKHRLPAKHVVHHVKH"
ORIGIN
        1 tcgacttgca tgtgtaaagc atgccgccag cgttcaatct gagccaggat caaactctta
       61 tgtttaatct ctaagctaat ataacttctg gtctgcttct caaaagaaaa gaacgagaaa
      121 tgattaatat catatcttgt ctttacttct ttagcagtgt gaggcttttc gcactcacac
      181 ttatcggtaa tctgttttta aagagctatg ctacgacact caaagaacca accgaagcgg
      241 ctgtttcgtt gctgtgtcag cagcgaagaa gccgaatctt acgcacatct cgcctacccg
      301 tcaacaccca atcaacaata tatttacatg aaaatgaaaa cctgctgatt tacttgcgtt
      361 ttatagggaa attattttaa gcaaccggcc agaagccttg tatttactgc atgaacaccg
      421 ctcaataaca atgcaaaatt cgataaccag accgaaaata aatccaatat tccccgatac
      481 agcatcacaa actgctttag caatgtcttc acattcaact tacaggccgc tttaagaact
      541 aatatctgta tatctatata gaatggctgt attaaaactg tatttaggac gatccaaaaa
      601 ttgcacttgc caccaaatgc aatagctact gttcaatgct ctatctatat aaagacacac
      661 agtatagtta tagtacaaac cccactgctc atcatatata gacagatata ggtattgatt
      721 cagtagtaac gccaacacaa tacaaatgcg gcctgtaaac ttatttacag gccgcttctt
      781 tatattatgt atatgtatca ctattgcgtc accgtctcag catactctgc ctgtatgggg
      841 acgacttgct ctgcacattg tgccaagcac tgggcgattt ctgattgcgc actggcgccc
      901 aattgctggc ggctcatgcc agtgctgtcc agtgctgcca agatgtgtac ttcagccacc
      961 gattgcggct gctgtaataa ggccaccaag gtttgccaca gactgatatc gccgtggtaa
     1021 gccggtgcgg ggtttaaatc accattgggc aatgggtaac gcacacacag tgcttgtact
     1081 ggcacaccag cgctaatcgg cgcttgaaac aagctgtgtt taaacggttt gagctgatgg
     1141 ccatcggtag aagtgccttc ggggaaaatg gcgatgttgg caccggcctg taaggcattg
     1201 ctgatgatat cgttagcggc caaggcggca gcgcggttgc tgcggctgat gaagatggta
     1261 tcggagcgcg ccaccagcca accgataaca ggccaagttt gaatgtcgtc tttgccgacg
     1321 aaacgcatcg gctgtaccgc attgatggcg aagatgtcca accacgacac atgattggaa
     1381 acccaaaagc ggcctgtatc tttcggtatc gcggcaatgt cacccaccac ttgcacgcgc
     1441 atgccgcaca cgcccaataa ttgtgccgac caattttgga tgcggcgctg tttttgtgct
     1501 ggggtgctgc gcccaaaaaa cagtgcgatt tgggtgcaac ctgacaacaa atgccaaccc
     1561 acgcggccca tgcgccatgc cagtaataac ttattgcctg atgttgccat ggtcttattt
     1621 caaaaagtga cgcgcatagc gaggattgat gcgcgatatc ggcatcatca ccaacacatc
     1681 ggcactgtta aaatcggtgt cccaatgcgg ctcgccacag atgtacgcac cggcacgcac
     1741 atagccttta atcaaagcag gaagctcgac ttccaagtct tgttgtaagg cagctatcgg
     1801 taacgggttt ttcgggaaca cgcggtattc aggcggggcg taacactgtt cttgcaggcg
     1861 tcggaacatg ctggcggcgc tgtgaccgcc gtctttcatg cacatgctgc cgcaacctat
     1921 catgtattcc aaaccttgtt gctgcatgaa ttgcatcaat cccgcccaca ataaggtgat
     1981 ggtactgccg gagcggtagt cttggtgcac gcaggcgcga ccgagctcta ccgtgtgtgg
     2041 caagatgtgt tgcaaacggc ttaagtcaaa ctcgctggca gaataccaac cgccgacggc
     2101 ggcagcgcct tcggctgtca acaaacggta acatccgatg atgcggtcgt tttcgcgctc
     2161 gcgcaccaac aagtgttggc aatgttcatc gtatttgtcc acgtccaaac cattgttgga
     2221 cacgatattg gcgcccatct cttcggcgaa cactttgtaa cgcaagcgct gtgcttcttc
     2281 tatctcaaac tcactgcgcg caagcgacac gcttaaacta ccaccttgga tgtgaacgtg
     2341 actttgggat tgcagttgta acattacttt tctccgtgtt gagtatgtta aagcacgatg
     2401 ctgctcactc tacaaagtgt gaatgacaaa catgtgtcag ctgacaaaac attgaagcgc
     2461 tgtgttgcag tgatatgact taagactacc aagcttgctt taagtttttt acacaataaa
     2521 aagcgtcctg taaaccttac aggacgcttt ttgtgcaact gtttgcaata tgcgacttta
     2581 agcagcgatg cgtgttttga ctgcttctgc caattctgcc aacagcactt cagtatcgtc
     2641 ccaaccgatg cacgcatcgg taatgctttg gccgtagcac aatggttgac cttcgaccaa
     2701 atcttggcga ccttcaacca aatggctctc tatcatcacg cccatcaaat tgctttcacc
     2761 ggctttgatt tgctcggcca catcgcgacc gacttccatt tgcaattcgt atttcttgcg
     2821 gctgttggca tggctgcaat cgaccatcaa tttggtggcg actttggctt tgctcaattc
     2881 ggccacggcg ttttgaatgg attcactgtc ataattggtg tttttgctgc caccgcgcaa
     2941 aatcacgtgg caatcaggat tgccggcggt gcgcacaatt gctgaatgac cgcttttggt
     3001 caccgacaag aaatggtgcg gattgctggc tgcacctatg gcatcaatgg cgatcttcat
     3061 attgccatcg gtaccgtttt taaagcctac tggacaagac aaacctgagg ccaattcacg
     3121 gtgaacttgg ctttcagtgg tgcgtgcacc aatcgcgccc cagctgatta aatcagcata
     3181 gtattgcggc gtaatcatgt ccaagaattc ggtagaggct gggatgccca tattgttcaa
     3241 ttgcaacaac aaatggcgcg cttggcgcaa gccgaagttg atgtcgaaag agccatccaa
     3301 atgtggatcg ttaatcaagc ctttccaacc gatggtggtg cgtggttttt caaaatacac
     3361 ccgcatcaca atgaccaatt ctttttcgta tttctttttc aatggcaaca agcgctcagc
     3421 atattccaag gcagctttgg ggtcgtggat ggagcaaggg cctaccacca ccaacaagcg
     3481 ttggtctttg ccatggatca aatctgaaat ttcagcacgg gtatcgtgta ccaaagtgct
     3541 ggcaggttct gttaatggca attcgtataa gtgggcaatc ggcggcaata attcttttat
     3601 ttctttgatt ttaacgtcgt cggtattttt catattgata ctcatgcaaa aactctgttt
     3661 ctcaaaaagc aattaaactc gaatgaagct aggctaaacg ctttgaaacc aaaaatcaag
     3721 cgcaattacg ggcaacaatt gaaattatat ttcaataccg gcaatttaaa taagttatat
     3781 taaaatttaa tttcttaaaa atgaatttat gacgaaattt atttcttaaa ataaaatttg
     3841 gcttcgtgtt aatggcgcaa aatctgttgc cgtgcagcaa aatggcaaaa tcactgtggt
     3901 gtcggctggt ggtgatttgg attacactct gtgtttcatt tattccattg aaaacaccat
     3961 gaaagcaatg atattggccg ccggtcgtgg cgaacgcatg cgtcctttaa ccgacaccac
     4021 tcccaaaccc ttattacccg tggggcgtga acctttaatc ggttggcatt tgcgccgttt
     4081 gcaacaagcc ggttttactg aggtggtgat taaccacgcg tggttgggtc agcaaatcga
     4141 agacgtgtta caagatggcc gcgattatgg tgtgcacatt gcctattcgc ctgaaggcgc
     4201 tcaaggcttg gaaactgccg gcggcatcgc caccgctttg ccgctgcttg gcgatgcgcc
     4261 ttttttggtc atcaatggcg atgtgctcac cgacattgat tttgcccaag cgactcgcat
     4321 tgcagcgcaa atggccacga ataacgcttt ggcacacctg tggttggtta acaatcccga
     4381 tcacaatccc aatggtgatt ttggcttaga cggcgagcat gttgtcagcc atgccgacac
     4441 gcaatacacc ttcagcggtt gcggcgtcta ccatccagcg ctgttccaac acacgcccgc
     4501 gcatcaagcc gccaaactcg cgcccttatt gcgcactgcc atggctgaac agcaagtcac
     4561 tggccacaaa cacacgggct tgtggttaga tgtgggcacg gttgagcgtt tgcaacaggc
     4621 caatgcactg atgcagcacg cttaatcact gagtaaatcc catttacagg ccgcagcaag
     4681 cattacaggc cgcgattaag cggcctgtaa attcaaatca cacatcacaa tactttaaaa
     4741 tcatcttggc tgagtaaatc aataccgcat tccaaatctt ctaaccaatc caagaaacgg
     4801 ttgaccattt ctttgccttt gaacgaggcg ccgtgttgcg gcacaatcca ttccacatcc
     4861 aattggcgca ccatgttcac ccaataacga caagctttgt tgccgctcat atagcgcttg
     4921 tggaaaccca acatgccatt gttgtgcaag tggtggtcaa aatcgtctat cggtttgccc
     4981 gcggtttcgg catcaaccaa agacgcaccg acgtcacctg agaacaggat tttgctgatc
     5041 ggatcgtaaa catggaaatt gccgactgga tgcaagaaat gcgctggcaa caaatgcagc
     5101 tcagcacctt gcaattccac cttcatgcct tgtgccggaa tgctggtcaa acggccagtg
     5161 gtcgcgcctt tcaaacaaaa atgcggaata aagcgttccc attctttggc aatcaacaca
     5221 ttcgcgtcgg taatcaacaa ccaaccattg atggaggcga tgatgtcagg gtcggcgtgc
     5281 gacgcgaaca catagcgcgt gtgcgaaggc aggaagtaat cggagatttc cgccaacaaa
     5341 tgtttgtaag ttaaattacc accggggtcg agcaacatgc catcgccttt gtgcacgatg
     5401 gcaaattgat tggactgtac accttcaccg gtaaccaaat ctgaaaaggc gacacatttg
     5461 tgttcaccgt cgtcgtataa aaccactgcc atgatgtgac tctttcgatt attgatttta
     5521 tgctagagag tgcttttata acataggcat aattacaagt gttttgctaa tgtgaatttg
     5581 cttgatatag actaaataat tcagtagttt tcaaccggtt ttgacaataa aaccacatag
     5641 ataccgacac atagccaaac aggccgcttg ccgcccatgt gtgacacatc agcgacagcg
     5701 gcctgtaaaa cggcaggttt atttcaacaa gcgaaaatcg tcttgggtga ttaaatctat
     5761 gccacattcc agctcttcaa accaatccaa gaagcgattg accatctctt tgcccttaaa
     5821 cgaagcgcca tgttgcggca cgatccactc gatgtccaat tggcgcacca tgttgaccca
     5881 ataacgacac gccttgttgc cactcatata acgctggtgg aaacccaaca tggaattgtg
     5941 gtgcaaatgg tggtcgaaat cggtcacggt ttgcgccgct tcttcagcat cgacgatgga
     6001 cgcgcccacg tcacctgaaa acaggatttt gctgatgggg tcgtaaatgt ggaaattgcc
     6061 gaccggatgc aagaaatgcg caggaatgat ttgcagctca ccgccgttca aatccaattt
     6121 catgccttgc ggcgggatgg tgaccatgcg cccaaccgtc gcgcctttta aacagaaatg
     6181 cgggataaag cgttcccatt cttccgcaat caacacttcg gcatcggtaa tcaacaacca
     6241 accattgacc gaggcgatga tgtcaggatc gggatgtgag gcaaaaatat agcgcgtgcg
     6301 cgatggcaaa aaataatcgg aaatctctgc caacaaatgt ttgtaagtca aattgccgcc
     6361 gggatcgagc aatactccct cgccattgtg agaaatggca aattggttgg cctgtacccc
     6421 ttcgcccgtc accaaatcag tgaataccac acacttatgt gttccatcgt catacaacac
     6481 caccgccatg tttatgctcc gtttcacaat tgattgatta atcactgcat tgcgatgatt
     6541 atggcatagg cgtttgggct gctgcgtggg gatggggcag aatctgcacc cttgttgaca
     6601 taaattaagc aagccgcaga ttcgggcttg cttaagtttg tgacttgttt ttgtgggcga
     6661 atttatgcca cagacaacaa ctctacttca aacaccaaag tggcattttt gggaatcaca
     6721 ccaccaacag cgcgattgcc ataagccaat tcaggcggga tggtcagttt gcgtttgccg
     6781 ccgaccttca tgccttctat gccttggtcc caacccttaa tcacttggcc tatgcccaac
     6841 acgatggtca atggctgttt gcggtctaag ctggaatcga atttggtgcc atcggttaac
     6901 caaccggtgt aatgcacagt cacttcttta ttggccacgg cttcagcacc ggcgccaacg
     6961 ctcaaatctt ctacttgtaa acccatagcg tttctttctt ggcaaaaggc gaatgtacca
     7021 caagccaagc gccatcagac tcaagcttta caaactgtga ccacagccaa acagggtttt
     7081 gggtttgtca tcggcgagca aggcggcctg taagccacgt ttggcacggc gtttggcctc
     7141 tatgccttgc cagatttttt catggaaata gaatacgacg gtattcacaa tcggctcgac
     7201 caatgctacg gtactggaaa tgccgatgct gcctgtgagc gcataggcaa cgctgaatgc
     7261 cacactgaag tgcaagatgg caaaagtcag ggttttaatc atgttatgac ctctttaaaa
     7321 ctgttggtga tttctatata caaatgataa ctattattat ttgtattttc caacaaaatt
     7381 tacaaatcat ggaattggtt ttctctataa ggacaaatat gagcagttgt cacatcgtgg
     7441 ttttggaccg cggcacctta atgcctttac cgtggacgtt tgattttgaa caccacctca
     7501 ccgaatacga tggcacaccc gacgaggaag ccattaaccg ttgccgcgac gccgaaatca
     7561 tcatcaccaa taaggtcaaa gtcgaccgcg ccaccataga ggccagcccg aatctgaaaa
     7621 tgatagccat tgctgccacc ggttttgagc atgtcgactt acaggccgct gctgagcgcg
     7681 gcatcatcgt ttccaacatc aaagcctatg gcaacgacac cgtcgccgaa cacgcgttca
     7741 tgttgatgat ggctttgatg cgccaattgc cggcttacca acgcgatgtc gccgcaggct
     7801 tatggcaaaa ctcgccttat ttctgccatt ttggtgcgcc catccacgac atcaatggca
     7861 aaacgctgtt gatattcggc aaaggtggca tcggttcggc cttggcgcaa cgcgccgaag
     7921 cgtttggcat gaaggtgatt tatggcgaac acaaaggcgc ggcggtgtgc cgtgagggct
     7981 atgtgccgtt tgccgaagcc ttgcaacaag cggatgtgat ttcgctgcat tgcccactca
     8041 atgcgcaaac gcgcaatatg ctcggcgaag aagaattgaa aacgctcaaa ccgggctgcg
     8101 tcatcatcaa cgtcggccgc ggtggtttgg tcgatgaaac cgcattgatc gccgcattga
     8161 aatacggcgg cttgggcggc gcgggtttcg atgtgattac caatgaaccg cctaccgaag
     8221 gcaatccttt ggtcaacacc catttgcccc atttaatcgt caccccacac atggcatggg
     8281 gcagccaaga agcgatgacg cgcttgttcc acatgctcat cgacaacatc aaccaaggca
     8341 tggccggcac gccccaaagc gtggtcttgc ccaaataagc ccacaccttg atacacaagc
     8401 ggcctgtaaa ccctaagaaa tggtttacag gccgcttttt atattgcttt tattattaag
     8461 atggccaacg ctttaatact gcgtgatata cgcctcactg cgccattgca tgtcgctttg
     8521 ggcaggccgt acttgataat gacggcacac cgcccgccgc aacgggtcat cgtcggcaat
     8581 caagccacca aagccgccca tccatgccca caccacgcct tggttcagca acatgctgcg
     8641 gcgcacatgc gatgcgtttt ggccttcgcg acacgccatt tgcacttgca ccaaatgcgc
     8701 atcgtgcgcc agcttgggaa acatgtcgct cacggccggc ggcgtgcgct catacaccac
     8761 ccatgccgtc atcgtttgcg gcaataccgc ttctggcaga atttggatgc tgtctaccaa
     8821 caaggtcacg cggcggtgat tgggatagtc tatgctttct tgtacgctgc ggcgctgaca
     8881 cacagattgc aaagtgtgtt gttccaagac tgttaacggc ggtggcacgc gcgcatccaa
     8941 ttgcaatgcc ggcagcgtct gcttgttcac cgccgcacgc atataggcca acacatcggc
     9001 cgcacggggc gaccattgct gtgccgttgg cgtgtggcaa tccaaattca gcatgtgcgt
     9061 gccttgctgg ctcacgcttt ccacatacac tttgccttga tagcgcacat cgctgtaagg
     9121 caataacagc cgctccggtg cctcaatcac aggtttgtcc gccggcgcac acgcccacac
     9181 gctgccacac aacgcccaca gtgccacatg tttcatcgcc gccactcctt tgccatcaag
     9241 accttgcgtc tgagcgctac agattaatcc aatacagact tgttcacaat cgtgtgctat
     9301 agcatcagca agcggcctgt aaacccaata gcgctttaca ggccgcttat tcatattaat
     9361 aactgccatg ccaataccca acgcttgttt cgaccgccat cgaagcgaga gtggatggct
     9421 gcgtttacag tatcgtcatc tgcacaccag ttactcagga accagcatgg acgacataca
     9481 cgtacgtttg gccaaccacc ccggcacttt ggcgcaattc ggacaattat tgggacaggc
     9541 cggcatcagc ttggaaggtg gcggcgtgtt tgccacgggc gacagcgccg aagcgcattt
     9601 tttggtggcc gacggcgagc gtgcggcgca agtgttgcgc gcggctggct tacacgtcat
     9661 cggccaacgc gcagtgctgg tgcgcaagct gcaccaagag cagcccggtc aattggggaa
     9721 aatctgtgcg cgcttggccg cccaccacat caacatccac accatgtaca gcgaccacca
     9781 caatcggtta atcttggtgg tagacgatgt ggccgccgct gccgcacaca ctcttgaatg
     9841 gcaagcctga catgcactcc tccgatcccg ccgtccacca tgtggcagaa ctggcgcgcg
     9901 ttttggccga acccaaacgc gtgctcatct tgttggcctt gatggatggc cgcgcttaca
     9961 ccgccaccga attggccttg atggccgaca tcgccccgtc taccgccagc agccatttgc
    10021 acaaaatgcg tgaacaaggc tttatcgcct gtgtgtcgca aggcaagcac cgctatttcc
    10081 gcctcagcag tgccgacatt gcgcaattac tggaacaact gctgcgtttt accgcgctgc
    10141 aaaagcccag catggtgccg tccacgccgc cgcatctacg gcaggcccgc acgtgttacc
    10201 agcatttggc cggtgaaatc gccgtagagc tggcgcaaga gatggtgacc gcgcaatggc
    10261 tgcaagcgga cagctatgat ttgaccgaac tcggccacca agcgctgtgt cgcaaaggcg
    10321 tgccactggc ggcatgggaa acttatccac aacagcaatg cacgtgcttg gattggagcg
    10381 aacgccaatt ccacatcggc aaacgcttgg gcagcacact gctgcgtttt ttcatgcagc
    10441 aaggttattt caataccgtg gccgaaagcc gcgagttggt gttaacgcac aaaggcaagc
    10501 agcatttgtt gcagcaacgc tttatccaaa cctgatgcac gggtttacag gccgcatgca
    10561 agtggtgatg gcctcttatt ccctctgtgt tgcaacagac acagacacac acccattttt
    10621 ccgcccactg tggcggcaca gaaagcctct tatgagcctc atcgttgcat tattgttgat
    10681 tttcttactc gcgggcatgg tcaaaggcgt catcggtttg ggcttgccca ccattgccat
    10741 gggtttgttg acggtgtttt acccgccggc caccgccgcc agtttgctgc tgataccctc
    10801 aaccgtcacc aatgtgtggc aattgtgctt gggcgcgcag ttgtggcctt tgtgcaagcg
    10861 gctgtggccc atgctcgccg gcatcaccat cggcacgctg tggagtgtgt tgccgccact
    10921 ttcgagcaac aatacttggg tgcatgcggg tttgggactg attttgtgtc tgtacgcgct
    10981 gtgggggctg ttagccaaaa aactgccctc gtctgcacgg catgagcgct ggttgtcgcc
    11041 gctcattggt tatgttactg gcacgattac cgccgctacc ggcgtgtttg tgttgcccgc
    11101 agtgccgtat ttgcaaacgc tgtcgctgtc caaagacgag ttaatccaag cgctgggctt
    11161 gtcgttcacg gtatcgacgc tggccttggc ggcgcaattg ctgtggcaac aaggcttgcc
    11221 gaacatgaat gtgggactgt cggcactggc catcgtccct gccattgtgg gcatgtatgt
    11281 tggccaatac ctgcgccaat tcatcagcga gacagtgttc aaacgctgct tcttcatcgg
    11341 tttgttgctg ctcggtggtt atatgttgct cagtgatgtg ctgaaataat cagcagaacg
    11401 attcaataca agcggcctgt aaatctgttg atggatttac aggccgctta tgattgaggg
    11461 tgtaacagtg ctcagtgttt cacatggtga accacgtgtt tggctggcaa acggtgtttg
    11521 tacgccactt ttttggcttg agcatgtttg atttgggcat ggtgtttcgc actagggtgt
    11581 tttttcacca ccactttgtg cgcaggacgg tgttgggcag tggggttttt taccgccact
    11641 tttttcacgt gtttgacttg gtgcgccgct actgggtgtt tcatgggctg atgactgggt
    11701 acggtagcgg ccatgctcat ggcagtgaaa gaagccaaga cggtggcgaa aatggcggta
    11761 acgatttttt tcatggtgtg actccttgct ggttaagctg tttggataga cacatcatgc
    11821 accgccagac ttagtggcaa cttagtacaa gtttaagtct ggtaaacgct gtgtaagcgt
    11881 gtttgagtaa accttaattc agattcagag ccctgttttg actggacaat ttttatccct
    11941 atatgcggcc tgtaagccta ttgcgagttt acaggccgct ttcatgtcca tgcacacccc
    12001 gccaaaccgc gttgattgca cattcatatg gaatagaagc ccgtctttgc tagtttgttt
    12061 actttaagtt aacaatatat tgaagatttg ctagtgtttt caactcgcaa gaagcaatac
    12121 actgcatcca tcaaatcaat aaacaacaac ttaaaggcaa acaaaatgaa aaaaaccatc
    12181 atcaccaccg tattggccgc attgagcatc tctactgcca tggcagccaa catcgctaac
    12241 ttcaccaatg cgaccgaaca acaaaaccca tacgcgcaaa gcaatgccca agtgcaaagc
    12301 caagccatcg ctaccgaaca agtgaattac ggcaaggtga atggcaaagt ggtgaaccca
    12361 ttgt
//
