GCF_900537995.1_Roseburia_intestinalis_strain_L1-82_genomic - 6 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_LR027880.1

Region	Type	From	To
Region 1	cyclic-lactone-autoinducer	530,504	549,841
Region 2	ranthipeptide	964,561	984,880
Region 3	RRE-containing	1,802,958	1,820,974
Region 4	cyclic-lactone-autoinducer	2,637,669	2,659,033
Region 5	cyclic-lactone-autoinducer,ranthipeptide	2,712,063	2,752,016
Region 6	cyclic-lactone-autoinducer	2,967,502	2,988,379

NZ_LR027880.1 - Region 1 - cyclic-lactone-autoinducer

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Location: 530,504 - 549,841 nt. (total: 19,338 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	cyclic-lactone-autoinducer	Similarity score	Type	Compound(s)	Organism
BGC0000367.1		0.04	NRP	gramicidin	Brevibacillus brevis NBRC 100599

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000367.1		0.19	NRP	gramicidin	Brevibacillus brevis NBRC 100599

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_LR027880.1 - Region 2 - ranthipeptide

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Location: 964,561 - 984,880 nt. (total: 20,320 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000820.1	0.13	Alkaloid	physostigmine	Streptomyces griseofuscus
BGC0000219.1	0.05	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000406.1	0.05	NRP	phosphinothricintripeptide	Streptomyces viridochromogenes
BGC0001625.1	0.04	Polyketide	isofuranonaphthoquinone	Streptomyces sp. CB01883
BGC0001386.1	0.04	Polyketide	JBIR-76, JBIR-77	Streptomyces sp. RI-77
BGC0000722.1	0.04	Other (Cyclitol), Polyketide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000964.1	0.04	NRP, Polyketide	burkholdac A	Burkholderia thailandensis E264
BGC0001045.1	0.04	NRP, Polyketide	spiruchostatin A	Pseudomonas sp. Q71576
BGC0000993.1	0.04	NRP, Polyketide	FR901228	Chromobacterium violaceum
BGC0000376.1	0.04	NRP	JBIR-34, JBIR-35	Streptomyces sp. Sp080513GE-23

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000820.1	0.42	Alkaloid	physostigmine	Streptomyces griseofuscus
BGC0000219.1	0.22	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000406.1	0.21	NRP	phosphinothricintripeptide	Streptomyces viridochromogenes
BGC0001625.1	0.21	Polyketide	isofuranonaphthoquinone	Streptomyces sp. CB01883
BGC0001386.1	0.20	Polyketide	JBIR-76, JBIR-77	Streptomyces sp. RI-77
BGC0000722.1	0.20	Other (Cyclitol), Polyketide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000964.1	0.20	NRP, Polyketide	burkholdac A	Burkholderia thailandensis E264
BGC0001045.1	0.19	NRP, Polyketide	spiruchostatin A	Pseudomonas sp. Q71576
BGC0000993.1	0.19	NRP, Polyketide	FR901228	Chromobacterium violaceum
BGC0000376.1	0.17	NRP	JBIR-34, JBIR-35	Streptomyces sp. Sp080513GE-23

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_LR027880.1 - Region 3 - RRE-containing

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Location: 1,802,958 - 1,820,974 nt. (total: 18,017 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001441.1	0.06	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000842.1	0.06	Other (Non-NRP beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000374.1	0.04	NRP	hormaomycin, hormaomycin A1, hormaomycin A2, hormaomycin A3, hormaomycin A4, hormaomycin A5, hormaomycin A6	Streptomyces griseoflavus
BGC0001558.1	0.04	Polyketide	cosmomycin C	Streptomyces sp. CNT302

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001441.1	0.26	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000842.1	0.24	Other (Non-NRP beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000374.1	0.18	NRP	hormaomycin, hormaomycin A1, hormaomycin A2, hormaomycin A3, hormaomycin A4, hormaomycin A5, hormaomycin A6	Streptomyces griseoflavus
BGC0001558.1	0.17	Polyketide	cosmomycin C	Streptomyces sp. CNT302

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_LR027880.1 - Region 4 - cyclic-lactone-autoinducer

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Location: 2,637,669 - 2,659,033 nt. (total: 21,365 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.1	0.08	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001728.1	0.04	NRP, Polyketide	paenilipoheptin	Paenibacillus polymyxa E681
BGC0000268.1	0.04	Polyketide	Sch-47554, Sch-47555	Streptomyces sp. SCC 2136

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.1	0.32	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001728.1	0.19	NRP, Polyketide	paenilipoheptin	Paenibacillus polymyxa E681
BGC0000268.1	0.17	Polyketide	Sch-47554, Sch-47555	Streptomyces sp. SCC 2136

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_LR027880.1 - Region 5 - cyclic-lactone-autoinducer,ranthipeptide

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Location: 2,712,063 - 2,752,016 nt. (total: 39,954 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.1	0.46	RiPP	enterocin NKR-5-3B	Enterococcus faecium
BGC0000488.1	0.42	RiPP	circularin A	Clostridium beijerinckii
BGC0000540.1	0.40	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000504.1	0.37	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000560.1	0.36	RiPP	subtilomycin	Bacillus subtilis
BGC0000543.1	0.35	RiPP	pep5	Staphylococcus epidermidis
BGC0000565.1	0.32	RiPP	goadsporin	Streptomyces sp. TP-A0584
BGC0000572.1	0.32	RiPP	capistruin	Burkholderia thailandensis E444
BGC0001551.1	0.31	RiPP	citrulassin E	Streptomyces glaucescens
BGC0000566.1	0.31	RiPP	streptolysin S	Streptococcus pyogenes M1 GAS

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.1	0.56	RiPP	enterocin NKR-5-3B	Enterococcus faecium
BGC0000488.1	0.53	RiPP	circularin A	Clostridium beijerinckii
BGC0000540.1	0.52	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000504.1	0.51	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000560.1	0.49	RiPP	subtilomycin	Bacillus subtilis
BGC0000543.1	0.49	RiPP	pep5	Staphylococcus epidermidis
BGC0000565.1	0.47	RiPP	goadsporin	Streptomyces sp. TP-A0584
BGC0000572.1	0.46	RiPP	capistruin	Burkholderia thailandensis E444
BGC0001551.1	0.46	RiPP	citrulassin E	Streptomyces glaucescens
BGC0000566.1	0.46	RiPP	streptolysin S	Streptococcus pyogenes M1 GAS

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_LR027880.1 - Region 6 - cyclic-lactone-autoinducer

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Location: 2,967,502 - 2,988,379 nt. (total: 20,878 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	cyclic-lactone-autoinducer	Similarity score	Type	Compound(s)	Organism
BGC0001521.1		0.15	NRP	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000607.1		0.12	RiPP	micrococcin P1	Macrococcus caseolyticus

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0001521.1		0.45	NRP	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000607.1		0.40	RiPP	micrococcin P1	Macrococcus caseolyticus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names