LOCUS       NZ_JH992960.1          10381 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JH992960.1 Alloiococcus otitis ATCC 51267 supercont1.4, whole
            genome shotgun sequence.
ACCESSION   NZ_JH992960
VERSION     NZ_JH992960.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:50:24
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 24086
            Orig. end    :: 34467
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10381
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[29086:29467](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5381
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10381
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10381
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             486..914
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 90.4; E-value: 1.2e-27)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_20"
                     /transl_table=11
                     /translation="MDRLEEALKTYIAIKRTNNRMTDAAKADVTHHGLNINEFAVLEVL
                     YHKGPQRIQHIKEKILIASSSTTYIIDKLADKGYIDRVRDQVDRRIYYAQLTRSGEQVM
                     DEIFPGHEKMILNLFDRMEDQEIYFLKELLKKMNGYGQ"
     PFAM_domain     585..758
                     /aSDomain="MarR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01047.24"
                     /description="MarR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_20_0001"
                     /evalue="3.70E-15"
                     /label="ctg4_20"
                     /locus_tag="ctg4_20"
                     /protein_end="91"
                     /protein_start="33"
                     /score="55.6"
                     /tool="antismash"
                     /translation="LNINEFAVLEVLYHKGPQRIQHIKEKILIASSSTTYIIDKLADKG
                     YIDRVRDQVDRRI"
     CDS             1045..1296
                     /locus_tag="ctg4_21"
                     /transl_table=11
                     /translation="MKALINIDYTNDFVADDGALTSGKPGQDLHDYILQTTKDFYDQGD
                     FVAFAIDLHQANDPYHPESKLFPAHNIEEVKAGTFMGT"
     CDS             1837..2817
                     /locus_tag="ctg4_22"
                     /transl_table=11
                     /translation="MSLKKRLIQAGSGLALAGALTFFGGQQAQAATWTPNTVADIQNVI
                     EEQAANQDGVIKYQFQWGDTLWGVSQATGISLDQLTQINDIQNADLIHVGTTIYLSNDN
                     SVVSVEEENEIRSYDVSEEVVVETETPEDVSEQTEAQEVEPSQEVAGEEAVAEEEPVAE
                     APAEESTANQESTDQAQGQDYAVENVSYNEPAQADQASQANPEPAPAPASGGVYSIATS
                     QLGAPYAWAGTSPAGFDCSGFVHWVYAQAGRSIPRSTGGLYSAATPVSNPQVGDLVFFG
                     NGGVSHVGIYAGNGQFIGAQTSTGVAHASVHSGYWGPRFIGYGRI"
     PFAM_domain     2023..2133
                     /aSDomain="LysM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01476.22"
                     /description="LysM domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_22_0002"
                     /evalue="8.20E-08"
                     /label="ctg4_22"
                     /locus_tag="ctg4_22"
                     /protein_end="99"
                     /protein_start="62"
                     /score="32.3"
                     /tool="antismash"
                     /translation="GDTLWGVSQATGISLDQLTQINDIQNADLIHVGTTIY"
     PFAM_domain     2509..2805
                     /aSDomain="NLPC_P60"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00877.21"
                     /description="NlpC/P60 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_22_0003"
                     /evalue="6.50E-27"
                     /label="ctg4_22"
                     /locus_tag="ctg4_22"
                     /protein_end="323"
                     /protein_start="224"
                     /score="93.7"
                     /tool="antismash"
                     /translation="GAPYAWAGTSPAGFDCSGFVHWVYAQAGRSIPRSTGGLYSAATPV
                     SNPQVGDLVFFGNGGVSHVGIYAGNGQFIGAQTSTGVAHASVHSGYWGPRFIGY"
     CDS             3033..3719
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 201.4; E-value: 2.4e-61)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_23"
                     /transl_table=11
                     /translation="MRVMLIEDDRDMSALIQMYLQPEGWEVDVFHMGKEAVLAFNRDSY
                     QILLLDLMLPDMTGFDICQAIRKETTIPIIMLTALEQSIHKIQGLNMGADDYIIKPFDP
                     GELIARIRAQLRRTYDYVTNPSLEETDQRRVKHLTLNKKFHQAYYQNQEIKLTPKEFAI
                     LWLLMEDPQGVYSMDDIHTRIWGDAVLDGEVNPVMVHVRRIRSKFEKIGVDIIQTVWGV
                     GYRINA"
     PFAM_domain     3039..3368
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_23_0004"
                     /evalue="1.20E-25"
                     /label="ctg4_23"
                     /locus_tag="ctg4_23"
                     /protein_end="112"
                     /protein_start="2"
                     /score="89.9"
                     /tool="antismash"
                     /translation="VMLIEDDRDMSALIQMYLQPEGWEVDVFHMGKEAVLAFNRDSYQI
                     LLLDLMLPDMTGFDICQAIRKETTIPIIMLTALEQSIHKIQGLNMGADDYIIKPFDPGE
                     LIARIR"
     PFAM_domain     3486..3710
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_23_0005"
                     /evalue="1.50E-20"
                     /label="ctg4_23"
                     /locus_tag="ctg4_23"
                     /protein_end="226"
                     /protein_start="151"
                     /score="73.2"
                     /tool="antismash"
                     /translation="QEIKLTPKEFAILWLLMEDPQGVYSMDDIHTRIWGDAVLDGEVNP
                     VMVHVRRIRSKFEKIGVDIIQTVWGVGYRI"
     CDS             3712..4794
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 106.5; E-value: 3.2e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_24"
                     /transl_table=11
                     /translation="MLKKNTFFIETILLQILWLVAGLIFSYILINLLDNLVFATIDHNQ
                     GLNLAQGVYYEARPYIMLLILPSLIVLGAFAIQYKRFKKYQSYYASGMAYLKGDAPSVE
                     TFHESMADDRLTFINLRQKQVDMERDYQIAYREKTDLLTYLAHDIKTPLANMLGYTKLL
                     HEEEDLSPDQRGKFIQVIYDNANYLNKLTEDFFDYLKFSLNDIPLQIVKLDVTVFFSQW
                     AEERELSLKNKTLQVTFSNCQDITLQTDPHLLLRVMDNLINNAQKYALDQSQIHVYVAR
                     DEKLLSVQVMNEVDQDLTFDWSKAKSRFYQGDYSRNRLINEGSGLGLTIVDDIVRHLGG
                     HFAIDQNEAKVTASLTFPLP"
     PFAM_domain     4123..4305
                     /aSDomain="HisKA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00512.27"
                     /description="His Kinase A (phospho-acceptor) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_24_0006"
                     /evalue="5.80E-11"
                     /label="ctg4_24"
                     /locus_tag="ctg4_24"
                     /protein_end="198"
                     /protein_start="137"
                     /score="42.4"
                     /tool="antismash"
                     /translation="KTDLLTYLAHDIKTPLANMLGYTKLLHEEEDLSPDQRGKFIQVIY
                     DNANYLNKLTEDFFDY"
     PFAM_domain     4480..4782
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_24_0007"
                     /evalue="9.30E-07"
                     /label="ctg4_24"
                     /locus_tag="ctg4_24"
                     /protein_end="357"
                     /protein_start="256"
                     /score="28.8"
                     /tool="antismash"
                     /translation="VMDNLINNAQKYALDQSQIHVYVARDEKLLSVQVMNEVDQDLTFD
                     WSKAKSRFYQGDYSRNRLINEGSGLGLTIVDDIVRHLGGHFAIDQNEAKVTASLTF"
     CDS             5001..5381
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_25"
                     /sec_met_domain="Lactococcin_972 (E-value: 2.7e-13,
                     bitscore: 43.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKILTTILLSATLLNTGLVVSAKDNQIPYVEGLGYETDIIQQET
                     STVTLYKTDSGWKDFLGGRWSHGVNERYVWSKYDHNSKTHKTTVQGAGGKLSYSGWTKP
                     GKRASASWEKALFGNKAWADVK"
     PFAM_domain     5184..5366
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_25_0008"
                     /evalue="2.90E-09"
                     /label="ctg4_25"
                     /locus_tag="ctg4_25"
                     /protein_end="122"
                     /protein_start="61"
                     /score="37.4"
                     /tool="antismash"
                     /translation="GGRWSHGVNERYVWSKYDHNSKTHKTTVQGAGGKLSYSGWTKPGK
                     RASASWEKALFGNKAW"
     CDS             5470..7623
                     /locus_tag="ctg4_26"
                     /transl_table=11
                     /translation="MKKTTGILTVVLMVVLSLGYFIYRDDTVMKQVFKEFDTTVNIVSN
                     PEQIKQNIETIQVLAQANDLIFVKQVSPPKDSPYAKQEIYFYVSGQGLGPSEKSSQDQP
                     GLGQFDAEHLSTLLTRKKLQARPFAEINPEDFNGDYQVKGKADRVQDFVDQLNQKTSLA
                     IQANIDPNFSQVSQYTVKQAFIYGLSVFVLAASLIFCFIMYNSTLSKEISVVNLLGYNK
                     AEFSPHKSAFLLLGPSLLSLFLSTLLLYFFSQSKSLLRFILAVKDFYLFFTIIVGLLFG
                     LECILLMWKVQKSKTLLWLKGMRTYHSKLFLFAKTASLTLVLYLLTLSVFGLANYLRMQ
                     PYLASWDKAQAYGNIACSWPMSYEENDQKFQSQILPNLNDLWDQLDDQGAILFESPNMT
                     ELNSQLREDQDYLNSLPFNGKYAYINQNYLDVSSLLDDKGQVLKDYEMKDKAWTIFVPE
                     SLDVTEEDRRAIRQDHFDQVLDKEAITEDYVFIQDKQEVFSFDSRQKISEGNLRDYVFI
                     MVQGSELDPAFSIKLPSLVNASFHPYLTQPQQAYQSLKETIDQTKASPYILYVSNIFND
                     MTYRIEEYKIESFIYLFAFILALFILFSVLAIDRDNYFYSQGQRIEVLRLLGYPQVAIH
                     KRKLVQNFLLYGLSIMALSVFLLASDYLSSYGLYSPEGGWLNQFFPILNLLVTLCLYLS
                     FLLEYRSWKKRESRMVEGLKEGT"
     CDS             7624..7860
                     /locus_tag="ctg4_27"
                     /transl_table=11
                     /translation="MSLNPLIKMTELSKQYGSHTILDQVNLEVYPGDLICIFGASGGGK
                     STLLNIMGTLEDYQAGHLECFNKLDPVQREKNK"
     PFAM_domain     7687..7821
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_27_0009"
                     /evalue="3.80E-09"
                     /label="ctg4_27"
                     /locus_tag="ctg4_27"
                     /protein_end="66"
                     /protein_start="21"
                     /score="37.3"
                     /tool="antismash"
                     /translation="LDQVNLEVYPGDLICIFGASGGGKSTLLNIMGTLEDYQAGHLECF
                     "
     CDS             7862..8290
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 107.5; E-value:
                     1.5e-32)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_28"
                     /transl_table=11
                     /translation="LLRRTKIAYLFQNFALVDNMTVKENMMLAVKYSQFESKGQAIDQA
                     LLKVGLEDKQESKLYELSGGQQQRLALARNMVKPFDLMLADEPTGLLDETNKQMVMQTL
                     LELNHEGKTIVVVSHDNDFKTIASKNYLIKNKKVERVL"
     PFAM_domain     7871..8128
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_28_0010"
                     /evalue="3.00E-16"
                     /label="ctg4_28"
                     /locus_tag="ctg4_28"
                     /protein_end="89"
                     /protein_start="3"
                     /score="60.3"
                     /tool="antismash"
                     /translation="RTKIAYLFQNFALVDNMTVKENMMLAVKYSQFESKGQAIDQALLK
                     VGLEDKQESKLYELSGGQQQRLALARNMVKPFDLMLADEPT"
     CDS             8291..8881
                     /locus_tag="ctg4_29"
                     /transl_table=11
                     /translation="MIKKIILALVGLLCIGGLLLVVTRKQDEIDPGLVVQNDTGKNFEA
                     VGIMVEDKAVLNKSNGEDFYIPEELLKGLDEFSLVAINDSGQAWTSPAVNPDGKKVTIK
                     NMDGGQLHTNQKEIEKFDDPLDIPNLNEWQIYTEGDTIHGSFDAKTDLAYTLYILGKGG
                     KLGISDTQSGQKVEASWEKPDDKLDSWLVFSKA"
     CDS             9115..10308
                     /NRPS_PKS="Domain: Aminotran_1_2 (42-384). E-value:
                     6.2e-71. Score: 231.2. Matches aSDomain:
                     nrpspksdomains_ctg4_30_Aminotran_1_2.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109:8-amino-7-oxononanoate synthase (Score: 433.2;
                     E-value: 1.5e-131)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_30"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.1e-07,
                     bitscore: 23.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQILETFLKSNLEELEEKGLLTTIDVLEDQGNGPIIKIEGRELI
                     NFASNNYLGFATRQELIDADIAATKQYGVGAGAVRTINGTLDIHRKLEEKIADFKGTED
                     AIAFQSGFNGNIGAIPAVMKKGDAILSDELNHASIIDGCRLSGAKIIRVNHQDMADLEA
                     KAKEASESGQYGKIMFITDGVFSMDGDIAQIDKIVEIADKYDLITYVDDAHGTGVLGKG
                     AGTVKEFGLQDKIDMQLGTLSKGVGVVGGYIAGSSLLIKWLKSQARPFLFSTSLTPGSA
                     GAIIRAIDLMQDQPELVQKVWDNANYFKAELKKIGYDIGQSQTPITPVILGDEKLAQEF
                     SHKLMEKGVYAKPIVYPTVPLGTGRVRNMPNAGHSKDMIDQAIKIYQEVGRELNIIN"
     aSDomain        9139..10302
                     /aSDomain="TIGR01825"
                     /aSTool="tigrfam"
                     /description="gly_Cac_T_rel: putative pyridoxal
                     phosphate-dependent acyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg4_30_0001"
                     /evalue="3.20E-177"
                     /identifier="TIGR01825"
                     /label="ctg4_30"
                     /locus_tag="ctg4_30"
                     /protein_end="396"
                     /protein_start="8"
                     /score="586.9"
                     /tool="antismash"
                     /translation="LKSNLEELEEKGLLTTIDVLEDQGNGPIIKIEGRELINFASNNYL
                     GFATRQELIDADIAATKQYGVGAGAVRTINGTLDIHRKLEEKIADFKGTEDAIAFQSGF
                     NGNIGAIPAVMKKGDAILSDELNHASIIDGCRLSGAKIIRVNHQDMADLEAKAKEASES
                     GQYGKIMFITDGVFSMDGDIAQIDKIVEIADKYDLITYVDDAHGTGVLGKGAGTVKEFG
                     LQDKIDMQLGTLSKGVGVVGGYIAGSSLLIKWLKSQARPFLFSTSLTPGSAGAIIRAID
                     LMQDQPELVQKVWDNANYFKAELKKIGYDIGQSQTPITPVILGDEKLAQEFSHKLMEKG
                     VYAKPIVYPTVPLGTGRVRNMPNAGHSKDMIDQAIKIYQEVGRELNII"
     aSDomain        9241..10266
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg4_30_Aminotran_1_2.1"
                     /evalue="6.20E-71"
                     /label="ctg4_30_Aminotran_1_2.1"
                     /locus_tag="ctg4_30"
                     /protein_end="384"
                     /protein_start="42"
                     /score="231.2"
                     /tool="antismash"
                     /translation="ELINFASNNYLGFATRQELIDADIAATKQYGVGAGAVRTINGTLD
                     IHRKLEEKIADFKGTEDAIAFQSGFNGNIGAIPAVMKKGDAILSDELNHASIIDGCRLS
                     GAKIIRVNHQDMADLEAKAKEASESGQYGKIMFITDGVFSMDGDIAQIDKIVEIADKYD
                     LITYVDDAHGTGVLGKGAGTVKEFGLQDKIDMQLGTLSKGVGVVGGYIAGSSLLIKWLK
                     SQARPFLFSTSLTPGSAGAIIRAIDLMQDQPELVQKVWDNANYFKAELKKIGYDIGQSQ
                     TPITPVILGDEKLAQEFSHKLMEKGVYAKPIVYPTVPLGTGRVRNMPNAGHSKDMIDQA
                     IK"
     PFAM_domain     9241..10266
                     /aSDomain="Aminotran_1_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00155.23"
                     /description="Aminotransferase class I and II"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_30_0011"
                     /evalue="2.20E-68"
                     /label="ctg4_30"
                     /locus_tag="ctg4_30"
                     /protein_end="384"
                     /protein_start="42"
                     /score="231.2"
                     /tool="antismash"
                     /translation="ELINFASNNYLGFATRQELIDADIAATKQYGVGAGAVRTINGTLD
                     IHRKLEEKIADFKGTEDAIAFQSGFNGNIGAIPAVMKKGDAILSDELNHASIIDGCRLS
                     GAKIIRVNHQDMADLEAKAKEASESGQYGKIMFITDGVFSMDGDIAQIDKIVEIADKYD
                     LITYVDDAHGTGVLGKGAGTVKEFGLQDKIDMQLGTLSKGVGVVGGYIAGSSLLIKWLK
                     SQARPFLFSTSLTPGSAGAIIRAIDLMQDQPELVQKVWDNANYFKAELKKIGYDIGQSQ
                     TPITPVILGDEKLAQEFSHKLMEKGVYAKPIVYPTVPLGTGRVRNMPNAGHSKDMIDQA
                     IK"
ORIGIN
        1 tcttgcaggg gagtgaggaa atcttgccag tcaagtatga agtgatcgag gaagaaaacc
       61 acctcagcct ggatacagtt gtgggaacag gggtcagcta tatccagttt aacctcctta
      121 gtgatgaccg gcccatcagc cagtctgcca acctgcgtcg ggccgtcctt tacaccatca
      181 accaagatga gatgatagcg attgagcaag gcaacagcct gccagcccgg tcgaccttga
      241 cccctataat cgatacaggc aagcagggca tagaggcaga ctcagaaaaa gtagagttct
      301 actataatga atacctcaat gaataagtcc tgaaggaaag gcatgactcc caaagctagg
      361 agccatgtct ttttccatgg gtcagctaag acttaattct caagggaaat gagctggggt
      421 caaaaaagtt tgacaatcaa agtattcagt gatagggttt aagggtatta gaggtaggtg
      481 gtaggatgga ccgtttagaa gaagcgctca agacctatat tgccattaag cggaccaaca
      541 accgtatgac ggatgcagcc aaggcggatg ttacccacca tggtttaaat ataaatgaat
      601 ttgcggtttt ggaagttttg taccacaagg gtccgcagcg catccaacat attaaagaga
      661 agattttgat tgccagtagc agcacgacct atattatcga taagctggct gacaaaggct
      721 atatcgaccg ggttcgggac caggttgacc gccggattta ctatgcccaa ctgacccggt
      781 ctggtgagca agtaatggat gagatttttc ccggccatga aaagatgatc ctaaatctct
      841 ttgaccggat ggaagaccag gagatttact tcctaaaaga actacttaaa aaaatgaacg
      901 gctatggtca gtaagggtct tggtcgtctt attctgattt ctagcaagct ataggttggg
      961 gcatgaaaga ccatgtctta gccttctttt tacttgcttg gacctccaac ttaaccgtat
     1021 acttacttgt aagaggtgtt taagatgaaa gcattgatta atatcgacta tacaaacgat
     1081 tttgttgcgg acgatggggc tttgaccagt ggcaaaccag gccaggacct ccatgactat
     1141 atcttacaaa ctaccaagga cttttatgac cagggggact ttgtggcctt tgccattgac
     1201 ctccaccagg caaacgaccc ctaccaccct gaaagtaaac tctttcccgc ccataatatt
     1261 gaagaagtga aggccggaac ctttatgggg acttagaaga ctactaccaa tccatcaaag
     1321 atgccagcaa tgtttactat acggacaaga cccggtactc agcctttgcg gggaccgacc
     1381 tggccattaa gctaagagag cgggggatta cagaagtcca tttactagga gttgtaacca
     1441 atatctgtat cctccacacg gctattgatg cctgcaactt gggctttgat attgtcgtcc
     1501 atcaaaaggg tgtggcttca tttagccagg aagggcatga ctttgccatg gaccacttta
     1561 aaaatacctt aggagctaag attgtttaaa gctaaaagac cagggaatca tctttattaa
     1621 gcagattatt atttcaagga tgttacagtt ttacagactt ttgtaaagaa tccattgatt
     1681 gtgtcaaaac aaagtcaatc gggctaagga gcaatgacaa ttgcccttta gcccttttct
     1741 ttataaatat ttgcctgtag tatattggtt gtcgctgatg agactagcga aacggaaaaa
     1801 acaaaaagga aatatttata aaggagttat tattacatgt cacttaagaa aagattgatc
     1861 caagccggtt ctggtttagc cctagcaggt gccttgactt tcttcggtgg tcaacaagcc
     1921 caagccgcaa cttggacccc aaatactgtt gctgatattc aaaacgtcat cgaagaacaa
     1981 gcagccaacc aagacggtgt cattaaatac caattccaat ggggcgacac tctttggggt
     2041 gtatctcaag caactggtat tagcttggac caattgactc aaatcaatga tattcaaaat
     2101 gctgacttaa tccacgttgg cactaccatt tacttaagca atgacaattc tgttgtttcg
     2161 gtagaagaag aaaatgaaat tcgctcctac gatgtttcgg aagaagtcgt tgtcgaaact
     2221 gaaacaccag aagatgtttc agaacaaact gaagctcaag aagttgaacc tagccaagaa
     2281 gttgctggtg aagaagcagt agcggaagaa gagccagtag cagaagctcc cgctgaagaa
     2341 agtactgcaa accaagaaag cacagaccaa gcacaaggtc aagactacgc tgttgaaaac
     2401 gtcagctaca atgagccagc tcaagcagac caagcttctc aagctaaccc tgagccagct
     2461 ccagcaccag caagcggtgg cgtttactcc attgcaacta gccaacttgg tgcaccttat
     2521 gcttgggccg gaacttctcc agcaggcttt gactgctccg gtttcgtaca ctgggtctat
     2581 gcccaagcag gccgttccat tcctcgttca actggtggcc tttactcagc tgctacacca
     2641 gtttctaacc cacaagtagg tgacctagta ttcttcggta acggtggcgt ttcccacgtt
     2701 ggtatttacg ctggtaacgg ccaattcatc ggtgcccaaa cttcaaccgg tgttgcccac
     2761 gctagtgtcc actctggtta ctggggccct cgtttcatcg gttacggccg catctaattt
     2821 ccttaatagc catacttttc cctctggggc tctgcctcag agggtttttt tataaaaata
     2881 gccttcatcc ttatttgaac tggctttgaa ctagctttgt ggtaagatag ctttaagaaa
     2941 atttcgattt gacttccttt aaaataacta acgttttata aatgatcgct atcggtcgaa
     3001 acggattaaa ccaaagcaag gagatgggga agatgagagt catgttgatt gaagacgacc
     3061 gggacatgtc agctcttatt caaatgtatt tgcagcctga aggttgggaa gtagacgttt
     3121 ttcatatggg caaggaagca gtcttggcct ttaatcgaga tagctaccag attcttttgt
     3181 tagacctcat gttgccagat atgactggct ttgatatttg ccaggctata cgcaaagaga
     3241 caaccattcc tatcatcatg ttgaccgcac tggagcagtc tatccacaag attcaaggct
     3301 taaatatggg ggcagatgac tacattatta aaccctttga tccaggtgaa ttaattgccc
     3361 ggattagggc tcaattaaga cggacctatg attacgtcac aaatcctagc cttgaggaga
     3421 ctgaccaaag aagggtaaaa catttaactt taaacaagaa attccatcaa gcttactatc
     3481 aaaatcaaga aataaaatta acgcccaagg aatttgctat tttatggttg ctgatggaag
     3541 atcctcaggg tgtatacagt atggatgata tccacacgag gatttggggg gatgcagtcc
     3601 tagatggtga agttaatcct gtcatggttc atgtcagaag aattagaagt aagtttgaaa
     3661 agatcggtgt cgacatcatc caaaccgtct ggggagtggg gtataggata aatgcttaag
     3721 aaaaatactt tttttataga gacgatctta cttcaaatac tttggctagt agcaggtttg
     3781 atcttttcgt atattctcat caacttattg gacaacctgg tttttgcaac aattgaccat
     3841 aaccaaggct taaatttagc tcaaggagtg tattatgaag caaggcctta tattatgctc
     3901 cttatcttac caagtctgat tgtattgggg gcttttgcaa tccagtataa gcggttcaaa
     3961 aagtatcaaa gctattacgc ttctggtatg gcctacttga aaggagatgc ccctagcgtt
     4021 gagaccttcc atgaatcaat ggctgatgac cgcttaacct ttattaactt gcggcaaaag
     4081 caagttgata tggaaagaga ttaccaaatt gcctaccgag agaaaacgga tttactgacc
     4141 tacctagctc acgatattaa gaccccctta gctaatatgc tggggtatac caaactcctt
     4201 cacgaggaag aagacctaag ccccgaccaa cgagggaaat ttatccaggt tatttatgac
     4261 aatgccaatt atctgaataa actgacggaa gactttttcg attatttaaa attcagcctc
     4321 aatgatattc ccttgcaaat tgttaagctg gatgtgacag ttttcttctc ccaatgggct
     4381 gaagaaaggg aattaagctt aaagaataag accctgcaag tgacttttag caattgccag
     4441 gatataaccc ttcagactga cccccacctg ctcttaaggg ttatggataa cctgatcaac
     4501 aatgctcaaa aatatgcctt ggaccaatcc caaatccatg tttatgttgc tagggacgaa
     4561 aagctactct cggtccaagt gatgaatgag gtggatcaag atttgacttt tgattggtcc
     4621 aaagccaagt ctcgttttta ccaaggagat tattctagga accgactaat caatgaagga
     4681 tctggactag gcttaactat tgttgatgat atcgtcagac accttggagg tcactttgcc
     4741 atcgaccaaa atgaggctaa agtgacagcc agtctgacct tccccctccc ttaaaaagca
     4801 aggaaaaaga aagaattaag acagtaaaat gtaaacactt gagctaagag ctagcctata
     4861 ctatcaatta ggttagctct tattgttaac caataataca gaaaggaata attgaaaatt
     4921 tcaacggaaa gtagtgaaga ttgtagatca tttaaaagtt acagtagttt gggatttata
     4981 agatataaag gagaaaacta atgaagaaaa tattaactac cattttattg tctgcaacat
     5041 tgttgaatac tggcctagtt gtttcagcaa aagataatca aataccgtat gtagagggtc
     5101 tagggtatga aactgatatt attcagcaag aaacaagtac agtgacttta tataaaaccg
     5161 atagcggatg gaaagatttt ttaggcggaa gatggagcca tggtgttaac gaaagatacg
     5221 tatggtctaa atacgaccac aatagtaaaa cacataaaac taccgttcaa ggagcaggtg
     5281 gtaaattatc ttattctggt tggactaagc caggtaaaag agcttctgct tcatgggaga
     5341 aagccttatt tggcaacaaa gcttgggctg atgtaaagta gtgagaaatt aatagaatgt
     5401 ttcaaggcac aatattgtgc cttggagcta ctattaaaaa gatagtattc aagacagcga
     5461 ggaataaaaa tgaaaaaaac gactgggata ctgaccgtag tcctcatggt ggttctaagt
     5521 ctgggatact ttatctaccg tgacgatacc gtcatgaaac aagtatttaa agaatttgat
     5581 actacagtta atattgtgag caatccagaa cagataaaac agaacatcga aacaatccag
     5641 gtcctagctc aagcaaatga tttgatcttt gtaaaacaag tttctccgcc aaaggatagt
     5701 ccttatgcca agcaagagat ctatttttat gttagtggtc aaggccttgg accaagtgaa
     5761 aagtcaagcc aagaccagcc tggtctaggt caatttgacg cagaacatct atcaactctg
     5821 ttaactcgaa aaaaactgca agctaggccc tttgctgaga tcaatccgga agacttcaat
     5881 ggggactacc aggttaaggg gaaagcagat agggtccaag attttgtaga ccaattaaac
     5941 caaaagacca gtctagctat tcaagcgaat attgatccca acttttccca agttagtcaa
     6001 tatactgtca aacaggcctt catctatggt ctttcagtct ttgttttggc tgcaagtttg
     6061 atcttctgct tcatcatgta taatagcact ctatccaaag agatatctgt agtgaattta
     6121 ttgggctaca ataaagcaga attttcaccc cacaagtccg ccttcctttt actagggcct
     6181 agtttgctat cccttttctt atcaactttg ctgctttatt tcttcagcca aagcaagtcc
     6241 ttgctccgtt ttatccttgc agtcaaagat ttttacctct tctttactat aatagtgggc
     6301 cttttgttcg gcttagaatg tatcctctta atgtggaaag tgcaaaaaag caagaccctt
     6361 ttatggttaa agggcatgcg cacttatcat agcaagctat ttttgtttgc taagactgct
     6421 tccctcactc tagtcctcta tcttttgacc ctatcggttt ttggtctagc aaactattta
     6481 agaatgcaac catacttggc aagctgggat aaggcacaag cttacggtaa tattgcttgt
     6541 tcttggccta tgtcttatga agaaaacgac caaaaattcc agagtcagat tcttcctaac
     6601 ctaaatgact tgtgggacca attagacgac caaggggcta tcttgtttga aagtcccaat
     6661 atgactgaat taaactcaca gctaagggaa gaccaagact acttaaatag tctgcctttt
     6721 aatgggaaat atgcctatat caatcaaaat tacttggatg tcagctcctt attggatgac
     6781 aagggtcaag ttttaaaaga ttatgaaatg aaagataagg cttggactat ctttgtacct
     6841 gagtctttgg acgtaacaga agaagaccga agagcaatta ggcaggacca ttttgaccag
     6901 gttttagata aagaagcaat taccgaagac tacgttttta tccaagacaa acaagaagtg
     6961 tttagctttg atagtcggca aaagattagt gaaggcaatc taagggacta tgtcttcatc
     7021 atggtccagg gcagtgaact tgacccggct tttagcatta aattaccatc cctagtcaat
     7081 gctagcttcc atccttatct cacccagcct caacaggcct atcagagctt gaaggagacc
     7141 atcgatcaaa ccaaggccag tccgtatatc ctctatgttt ccaatatttt taatgatatg
     7201 acctaccgta ttgaagaata taaaattgag agttttattt atctctttgc cttcattttg
     7261 gctcttttta tcttgttttc tgtcctagct atcgaccgtg acaactattt ttatagtcag
     7321 ggacaaagga tcgaggtttt aagacttttg ggctacccgc aagtggccat ccataaaagg
     7381 aaattagttc aaaacttcct cctttatggc ttaagtatta tggccctaag tgtctttttg
     7441 cttgccagtg actacctgtc ttcctatggt ctttacagcc cagagggtgg ttggctaaac
     7501 caattctttc ctatactgaa tctcttggtt actttgtgcc tttacctatc tttcttgttg
     7561 gaatacaggt cttggaagaa gagggagagc cggatggtag aaggattgaa ggagggaact
     7621 taaatgagtt taaatccact gataaaaatg actgagcttt ccaaacaata tggctcgcac
     7681 acgattctag accaggttaa cttagaggtc tatccgggtg acttgatttg tatatttggt
     7741 gcaagtggtg gaggaaagtc aactttattg aatatcatgg gaacattaga agactaccaa
     7801 gctggtcact tggagtgttt taataaactg gacccagtgc aaagagaaaa aaacaagtga
     7861 attgttaaga cgaactaaaa tagcttatct ttttcaaaac ttcgccctag tggataatat
     7921 gacagttaaa gaaaatatga tgctagcagt gaaatatagc cagtttgaaa gcaaaggcca
     7981 agccatagac caggcccttt tgaaggtggg gcttgaagac aaacaagaat ccaagcttta
     8041 tgagctttcc ggaggacaac agcaacgttt ggccctagcc cggaacatgg tcaaaccctt
     8101 tgacttgatg ttagctgacg aacccactgg gttattggat gaaaccaaca agcaaatggt
     8161 catgcagact ttactggaac tcaaccatga aggaaaaacc attgtagttg tgagtcatga
     8221 caatgatttc aaaacaatag caagtaaaaa ttatctgatt aaaaataaaa aagtagaaag
     8281 ggtcctatag atgattaaaa aaataatact agctttagtc ggccttcttt gtatcggtgg
     8341 tttactatta gtggtgaccc gtaaacaaga tgaaattgat ccgggccttg tggtccaaaa
     8401 tgatacaggc aagaattttg aggcagtggg catcatggtt gaagacaagg cagttttaaa
     8461 taagagtaat ggagaagatt tttacattcc tgaagaattg cttaagggtt tggatgaatt
     8521 ctcactggtg gctattaacg atagtggaca agcctggacc tccccagcag ttaaccctga
     8581 cggtaagaag gttaccatta aaaatatgga cggtggccag ctgcacacca accaaaaaga
     8641 aattgaaaaa tttgacgacc ctttagacat acctaattta aacgaatggc aaatttatac
     8701 agagggagat acgattcatg gatcatttga tgcgaagaca gaccttgctt acacccttta
     8761 tattttgggc aagggtggta agttaggcat atcagacact caaagtggtc aaaaggtgga
     8821 agctagctgg gaaaaacccg acgataaact agactcctgg ttagtttttt caaaagctta
     8881 gaggaattaa tttcaaactt ttcctaagtt aaggactcat tcaattgaat ccctataagc
     8941 gcttgctatg gccatactgc actcaattct aatgtgattg tggtatggct tttcatggta
     9001 ttcaatcttc ttgggtccag aatgaaagtt tgttaaaata aactctaaaa gattgaaaac
     9061 ggtttattga tttcctataa taaagttgtc aaataaatag ggaggatgga aaatatgtca
     9121 caaattttgg aaacgttttt aaaatcgaac ctggaagaat tagaagaaaa aggactgctg
     9181 acgaccattg atgtcctgga ggaccagggg aatggtccca taattaaaat tgagggccga
     9241 gaactgatta actttgcctc caacaactat cttggctttg ctactagaca ggaactaatt
     9301 gatgctgata ttgcagctac caagcaatat ggtgtaggag ctggggctgt ccggaccatc
     9361 aacgggacct tagacatcca ccgcaagtta gaagagaaga ttgcagactt taaggggaca
     9421 gaagatgcca ttgcctttca gtccggtttt aatggcaata ttggggctat cccagccgtt
     9481 atgaaaaagg gggatgccat cttgtctgac gagctcaacc atgcttctat tattgatggc
     9541 tgtcgtctgt caggagcgaa gattatccgg gtcaaccacc aagatatggc agaccttgag
     9601 gccaaggcta aagaagccag tgaaagtgga caatacggta agattatgtt catcaccgat
     9661 ggggttttct ctatggatgg agatattgct caaattgaca aaattgttga aatcgctgac
     9721 aagtatgacc tcattaccta tgtggatgat gcccacggga ctggtgtttt aggtaaaggt
     9781 gccgggactg ttaaggagtt cggccttcaa gacaagattg acatgcaatt aggaaccttg
     9841 tctaaaggag taggggttgt cggcggctat attgcgggtt cctccctcct gatcaagtgg
     9901 ctcaagtctc aagcaagacc cttccttttc tcaacctcac tcaccccagg ctcagctggg
     9961 gctattatta gagctattga cctcatgcaa gaccagcccg aattggtcca aaaggtttgg
    10021 gacaatgcca actactttaa agcagaactt aaaaagattg gctacgacat aggacagtcc
    10081 caaaccccta ttaccccagt cattctggga gatgagaaac tagcccaaga attttcccat
    10141 aagttaatgg aaaaaggggt ctatgctaag cctatcgtat acccaaccgt accactaggg
    10201 acaggccggg tacgtaacat gcctaatgcc ggtcacagca aggacatgat cgaccaagcc
    10261 atcaagattt accaagaagt tggccgggaa ttaaacatta tcaactagga ggctaaacat
    10321 ggaaagagta ttgattacgg ggtctttagg ccagattggg tcggagttag ccgaacgctt
    10381 g
//
