LOCUS       NZ_LN908963.1          20561 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LN908963.1 Fournierella massiliensis strain AM2, whole genome
            shotgun sequence.
ACCESSION   NZ_LN908963
VERSION     NZ_LN908963.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:55:19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 179372
            Orig. end    :: 199933
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..20561
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[189372:189933](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10561)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..20561
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..20561
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(549..1946)
                     /locus_tag="ctg18_184"
                     /transl_table=11
                     /translation="MKQLFPRGKRIRPTDKDLVFHTALAALFPVFLLVVLLFHIRQIAG
                     TDWQEVSLSQIVQDVNIPYLLFSMGVAGLVCLTAVLLFWRYRRDEVKQLIHRQKLARMV
                     LENKWYESEQRKEDAFFKDLSSSRSKETITYFPKIYYRMKQGLLHIRVEITLGKYQEQL
                     LNLEKKLESGLYCELTDKELKDSYVEYTLLYDTIGGRISIEDVQAKDGRLRLMENVWWE
                     YDKLPHMLIAGGTGGGKTYFILTLIEALLRTNAVLSVLDPKNADLADLQAVMPDVYYKK
                     EDMLACIDRFYEEMMKRSEDMKLMENYRTGENYAYLGLPANFLIFDEYVAFMEMLGTKE
                     NAAVLNKLKQIVMLGRQAGFFLILACQRPDAKYLGDGIRDQFNFRVALGRMSEMGYGMM
                     FGETTKDFFLKQIKGRGYVDVGTSVISEFYTPLVPKGHDFLKEIKKLTDSRQGVQAACE
                     AKAAETD"
     PFAM_domain     complement(897..1268)
                     /aSDomain="DUF87"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01935.19"
                     /description="Helicase HerA, central domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_184_0001"
                     /evalue="1.90E-05"
                     /label="ctg18_184"
                     /locus_tag="ctg18_184"
                     /protein_end="350"
                     /protein_start="226"
                     /score="25.0"
                     /tool="antismash"
                     /translation="PHMLIAGGTGGGKTYFILTLIEALLRTNAVLSVLDPKNADLADLQ
                     AVMPDVYYKKEDMLACIDRFYEEMMKRSEDMKLMENYRTGENYAYLGLPANFLIFDEYV
                     AFMEMLGTKENAAVLNKLKQ"
     CDS             complement(1985..2362)
                     /locus_tag="ctg18_185"
                     /transl_table=11
                     /translation="MRLANGIVIDKEATFGALKFSALRREVHLQNEDGSVSEEIKERTY
                     DLKSRGQGRMIQVSIPASVPLKEFDYNAEVELINPVADTVATATFQGAEVDWYIKAEDI
                     VLKKGAAMNPQTPKKDVPPVK"
     PFAM_domain     complement(2048..2350)
                     /aSDomain="DUF961"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06125.13"
                     /description="Bacterial protein of unknown function
                     (DUF961)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_185_0002"
                     /evalue="1.00E-38"
                     /label="ctg18_185"
                     /locus_tag="ctg18_185"
                     /protein_end="105"
                     /protein_start="4"
                     /score="132.0"
                     /tool="antismash"
                     /translation="NGIVIDKEATFGALKFSALRREVHLQNEDGSVSEEIKERTYDLKS
                     RGQGRMIQVSIPASVPLKEFDYNAEVELINPVADTVATATFQGAEVDWYIKAEDIV"
     CDS             complement(2384..2698)
                     /locus_tag="ctg18_186"
                     /transl_table=11
                     /translation="MELKFVIPNMEKTFGNLEFAGEDKTEQRRINGRMAVLSRSFNLYS
                     DVQRADDIVVILPAEAGEKHFDFEERVKLVNPRITAEGYKIGTRGFTNYILHADDMVKA
                     "
     PFAM_domain     complement(2393..2689)
                     /aSDomain="DUF961"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06125.13"
                     /description="Bacterial protein of unknown function
                     (DUF961)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_186_0003"
                     /evalue="2.80E-39"
                     /label="ctg18_186"
                     /locus_tag="ctg18_186"
                     /protein_end="102"
                     /protein_start="3"
                     /score="133.7"
                     /tool="antismash"
                     /translation="KFVIPNMEKTFGNLEFAGEDKTEQRRINGRMAVLSRSFNLYSDVQ
                     RADDIVVILPAEAGEKHFDFEERVKLVNPRITAEGYKIGTRGFTNYILHADDMV"
     CDS             complement(2811..3878)
                     /locus_tag="ctg18_187"
                     /transl_table=11
                     /translation="MCALKLGSLFDGIGVFPLAASRNGIIPVWASEIEKSPIAITKRHF
                     PDMEHLGDITKIHGGNISPVHIITFGSPCQNLSKIGKREGLAGSKSGLFFQAIRIIEEM
                     RCATNGLYPVIAVWENVMGAFSSNDRMDFRAVLQSFSDTEISMPPTGGWANAGMVRGGK
                     TDLCWRLMDAQYWGKPRLVQRRKRIFLVADFRGQRSAEILFKPRDMFPLPPPCTDYGLP
                     TAGASRISLDKTRGKIPVIRPFQERRMRSAAKSGNQSAFLTSFGRPDEPFPTLLAKAVN
                     MISFWYEGEEKDGVLRNLTPVECERLMGLPDGWTAYGNLGQPISDNARCKALGNAIALP
                     CADYIMAGIAETIHE"
     PFAM_domain     complement(2835..3059)
                     /aSDomain="DNA_methylase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00145.19"
                     /description="C-5 cytosine-specific DNA methylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_187_0005"
                     /evalue="5.20E-06"
                     /label="ctg18_187"
                     /locus_tag="ctg18_187"
                     /protein_end="348"
                     /protein_start="273"
                     /score="26.1"
                     /tool="antismash"
                     /translation="TLLAKAVNMISFWYEGEEKDGVLRNLTPVECERLMGLPDGWTAYG
                     NLGQPISDNARCKALGNAIALPCADYIMAG"
     PFAM_domain     complement(3303..3866)
                     /aSDomain="DNA_methylase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00145.19"
                     /description="C-5 cytosine-specific DNA methylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_187_0004"
                     /evalue="3.50E-27"
                     /label="ctg18_187"
                     /locus_tag="ctg18_187"
                     /protein_end="192"
                     /protein_start="4"
                     /score="95.7"
                     /tool="antismash"
                     /translation="KLGSLFDGIGVFPLAASRNGIIPVWASEIEKSPIAITKRHFPDME
                     HLGDITKIHGGNISPVHIITFGSPCQNLSKIGKREGLAGSKSGLFFQAIRIIEEMRCAT
                     NGLYPVIAVWENVMGAFSSNDRMDFRAVLQSFSDTEISMPPTGGWANAGMVRGGKTDLC
                     WRLMDAQYWGKPRLVQRRKRIFLVA"
     CDS             4545..6119
                     /locus_tag="ctg18_188"
                     /transl_table=11
                     /translation="MNQTQQKEYSRKAAQYQQLALPITQNIEIAEDEPVFVANAQLEEL
                     DYRKLYKAYSPKGRKSAAEPRIMFKLLVYGYMCGIYSTRKLEQACRKNIDFIWLLQGER
                     VPDHTSFARFRSGKAKDAIEDLFYQFVRRLWEEEEIEYEEVFIDGTRMESMANRYTFVW
                     RKSVTRQLAKVKEKARELFYQYGGEGNLTVGKLQALAKSLVPEGGEMVHGTGRRKPFWQ
                     RQYEEIDRLVVRWKKYERQLFEMGCHRNSLSKTDKDATFMRMKEDHMGNGQLKPAYNVQ
                     LAVNSEYITGVAAFSNCTDSGTLIPFLNHIQRMQGRSYRDIVADAGYESVGNYLYLASR
                     GQNCYIKPTNYQTRKTRKYCEQLWRAENMRYLEDEDCFVCAAGRKLRFYRSCSQESNGV
                     VTTYNYYQCDQCTGCPVRKQCTKSQNPDFRKEVKICEEFAQHRAQAHENLLTERGVLLR
                     MNRSIQVEGAFGVLKSDRQFKRFLMRGKTNISLELFLLCLAFDLDKYCSKLRQDRRKTH
                     LFPLKKE"
     PFAM_domain     4716..4931
                     /aSDomain="DUF772"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05598.13"
                     /description="Transposase domain (DUF772)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_188_0006"
                     /evalue="1.40E-18"
                     /label="ctg18_188"
                     /locus_tag="ctg18_188"
                     /protein_end="129"
                     /protein_start="57"
                     /score="66.8"
                     /tool="antismash"
                     /translation="GRKSAAEPRIMFKLLVYGYMCGIYSTRKLEQACRKNIDFIWLLQG
                     ERVPDHTSFARFRSGKAKDAIEDLFYQ"
     PFAM_domain     5679..6062
                     /aSDomain="DDE_Tnp_1_6"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13751.8"
                     /description="Transposase DDE domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_188_0007"
                     /evalue="5.10E-26"
                     /label="ctg18_188"
                     /locus_tag="ctg18_188"
                     /protein_end="506"
                     /protein_start="378"
                     /score="91.5"
                     /tool="antismash"
                     /translation="VCAAGRKLRFYRSCSQESNGVVTTYNYYQCDQCTGCPVRKQCTKS
                     QNPDFRKEVKICEEFAQHRAQAHENLLTERGVLLRMNRSIQVEGAFGVLKSDRQFKRFL
                     MRGKTNISLELFLLCLAFDLDKYC"
     CDS             complement(6313..7710)
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 130.8; E-value: 1.5e-39)"
                     /gene_kind="other"
                     /locus_tag="ctg18_189"
                     /transl_table=11
                     /translation="MASIVKRKSKYSVVYAYIDEHGKRRQRWETFDTSAEAKKRKTQIE
                     YEQETGNFIVPTAKTLADLLNEYMSIYGVNTWAMSTYESRKGLMRNYIIPIIGDLCLAD
                     ITPRMMDKYYRDLLNVKSVSINNRKPTSEYLSAHTVREIHKLLRNAFNQAVRWEMIPRN
                     PVLNATLPKAEYKKREIWSPDMLAKALEVCDDPILSLAINLAFSCSLRMGELLGLTWDC
                     VDISPQSIEAGNASIFINKELQRVTRGALDDLSDKGVVRKFPPCIASTHTALVLKEPKT
                     KTSIRRVYLPQTVAQMLVKRKEEIAELMDLFGDEYIDNDLVFCSSNGRPMESQIINRAF
                     SKLIEDHGLPHVVFHSLRHSSITYKLKLNGGDMKSVQGDSGHAQMKMVADVYSHIIDED
                     RCLNAQRFEAAFYAPKQSSPAAASVTPEQPAIKQKEEDSMSDTAKILELLKNPETAALL
                     KQLVSAL"
     PFAM_domain     complement(6526..7134)
                     /aSDomain="Phage_integrase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00589.24"
                     /description="Phage integrase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_189_0009"
                     /evalue="2.00E-16"
                     /label="ctg18_189"
                     /locus_tag="ctg18_189"
                     /protein_end="395"
                     /protein_start="192"
                     /score="60.4"
                     /tool="antismash"
                     /translation="CDDPILSLAINLAFSCSLRMGELLGLTWDCVDISPQSIEAGNASI
                     FINKELQRVTRGALDDLSDKGVVRKFPPCIASTHTALVLKEPKTKTSIRRVYLPQTVAQ
                     MLVKRKEEIAELMDLFGDEYIDNDLVFCSSNGRPMESQIINRAFSKLIEDHGLPHVVFH
                     SLRHSSITYKLKLNGGDMKSVQGDSGHAQMKMVADVYSHI"
     PFAM_domain     complement(7360..7533)
                     /aSDomain="Phage_int_SAM_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14659.8"
                     /description="Phage integrase, N-terminal SAM-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_189_0008"
                     /evalue="2.60E-09"
                     /label="ctg18_189"
                     /locus_tag="ctg18_189"
                     /protein_end="117"
                     /protein_start="59"
                     /score="37.2"
                     /tool="antismash"
                     /translation="TLADLLNEYMSIYGVNTWAMSTYESRKGLMRNYIIPIIGDLCLAD
                     ITPRMMDKYYRDL"
     CDS             complement(7713..8126)
                     /locus_tag="ctg18_190"
                     /transl_table=11
                     /translation="METTKTKKSVSVREMGKMLGLKKVESYWLVKKNYFTTIQVAGRMR
                     VMLDSFEDWYSGQFHYKKVDGTPPGTKWRDTTLSVPELAEMLGIHSATAYELVKRVHLE
                     TTIIDRRIRVMRDSFECWYDSQDRYKKCSERRE"
     PFAM_domain     complement(7758..7895)
                     /aSDomain="HTH_17"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12728.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_190_0010"
                     /evalue="2.20E-07"
                     /label="ctg18_190"
                     /locus_tag="ctg18_190"
                     /protein_end="123"
                     /protein_start="77"
                     /score="31.0"
                     /tool="antismash"
                     /translation="LSVPELAEMLGIHSATAYELVKRVHLETTIIDRRIRVMRDSFECW
                     Y"
     CDS             complement(8231..8458)
                     /locus_tag="ctg18_191"
                     /transl_table=11
                     /translation="MFQERIAELNRINEQNPVCFEKRTYTVDEIQDILGVSRPTAYNLV
                     KQELFRSVRVGGHIRISKKSFDEWLDQNAV"
     PFAM_domain     complement(8240..8386)
                     /aSDomain="HTH_17"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12728.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_191_0011"
                     /evalue="2.30E-17"
                     /label="ctg18_191"
                     /locus_tag="ctg18_191"
                     /protein_end="73"
                     /protein_start="24"
                     /score="63.0"
                     /tool="antismash"
                     /translation="YTVDEIQDILGVSRPTAYNLVKQELFRSVRVGGHIRISKKSFDEW
                     LDQN"
     aSDomain        complement(8243..8389)
                     /aSDomain="TIGR01764"
                     /aSTool="tigrfam"
                     /description="excise: DNA binding domain, excisionase
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg18_191_0001"
                     /evalue="1.40E-12"
                     /identifier="TIGR01764"
                     /label="ctg18_191"
                     /locus_tag="ctg18_191"
                     /protein_end="72"
                     /protein_start="23"
                     /score="45.8"
                     /tool="antismash"
                     /translation="TYTVDEIQDILGVSRPTAYNLVKQELFRSVRVGGHIRISKKSFDE
                     WLDQ"
     CDS             complement(9062..9493)
                     /locus_tag="ctg18_192"
                     /transl_table=11
                     /translation="MKNINLREYYPSIYPNDFYITVSDDIAEVFRKSENTEKAYYKKKK
                     RNKAYYSLDADPSLESHILGSEPSPMVLYEQKHLRMALYQAMEHLSEKQYRRLSAHLFQ
                     RMSISEIAHAEGISKASIQDSIEQALRTISKILVANSYI"
     PFAM_domain     complement(9101..9247)
                     /aSDomain="UPF0122"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04297.16"
                     /description="Putative helix-turn-helix protein, YlxM / p13
                     like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_192_0012"
                     /evalue="1.10E-05"
                     /label="ctg18_192"
                     /locus_tag="ctg18_192"
                     /protein_end="131"
                     /protein_start="82"
                     /score="25.6"
                     /tool="antismash"
                     /translation="LYQAMEHLSEKQYRRLSAHLFQRMSISEIAHAEGISKASIQDSIE
                     QALR"
     CDS             complement(9805..9987)
                     /locus_tag="ctg18_193"
                     /transl_table=11
                     /translation="MKNSTKKTVHTILKSLVQKSIEHESNKYASCPHVWAYQPHRPDAP
                     LLKTPPIDKIDPKNS"
     CDS             complement(10001..10561)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_194"
                     /sec_met_domain="AgrB (E-value: 9e-20, bitscore: 65.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTAANKITNYFLRIGLIEPYQSEWFTYILESRLTTLFSLPILIL
                     IGCFIAPIEVVITLNIGMLYLRPRINGFHSKTFIGCFMTSTLLELSSLFLFYYFDNVIA
                     YLTFFCSIFIILYLGPFNNSQIHFTEEEMIIARNKMHVSLVIFCLVTFIILFTFPILGR
                     CLIMSLNVVAFLLVIANLGFGIQ"
     PFAM_domain     complement(10028..10549)
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_194_0013"
                     /evalue="5.80E-17"
                     /label="ctg18_194"
                     /locus_tag="ctg18_194"
                     /protein_end="178"
                     /protein_start="4"
                     /score="61.7"
                     /tool="antismash"
                     /translation="ANKITNYFLRIGLIEPYQSEWFTYILESRLTTLFSLPILILIGCF
                     IAPIEVVITLNIGMLYLRPRINGFHSKTFIGCFMTSTLLELSSLFLFYYFDNVIAYLTF
                     FCSIFIILYLGPFNNSQIHFTEEEMIIARNKMHVSLVIFCLVTFIILFTFPILGRCLIM
                     SLNVVAFLLVI"
     CDS             complement(10653..11945)
                     /locus_tag="ctg18_195"
                     /transl_table=11
                     /translation="MNTLLLTALWLSIDLLYSHLFFDSFFPKRSHSFRRFLLFPIFTIA
                     GTILLTFSPSTYTPIVSILIFALINSFLHITSKAYSVFFSIIVYSIGCTIDNLVFTSFL
                     AFSGWHYSTLQSHFIVYLLLGMLSHGLPLIFCFAFHRSRKLKCTETTNWNWYSIPTVLS
                     FVCIMMEFYLNSCFQHDQIECVPLSVCAAFITIVNIASLLLVSWIERTSHFREESLLLH
                     AQIKVQSEGIEALSLSNTAQRKLTHDFRAHLEMLDSLLENKSFQEAANYITQLRAEQTE
                     RILLVNTHNSAMDAILNQKALIAKKHNIDVQFTVNDLSPLLIDAVDLTVIISNLMDNAI
                     EACEKLPIQERQIHVKALLEDAFFFSIRNRSETVQVCDNMVITTKPNTLLHGYGLQNVR
                     STLNKYDSYFGLDYQNGWFLAYAEIQNTPLS"
     PFAM_domain     complement(10686..10976)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_195_0014"
                     /evalue="3.50E-19"
                     /label="ctg18_195"
                     /locus_tag="ctg18_195"
                     /protein_end="420"
                     /protein_start="323"
                     /score="68.7"
                     /tool="antismash"
                     /translation="DAVDLTVIISNLMDNAIEACEKLPIQERQIHVKALLEDAFFFSIR
                     NRSETVQVCDNMVITTKPNTLLHGYGLQNVRSTLNKYDSYFGLDYQNGWFLA"
     CDS             complement(11942..12658)
                     /locus_tag="ctg18_196"
                     /transl_table=11
                     /translation="MTVKILVCDDDPTFVNQLVELINRQPKYGTSNISITGCSDPSQLN
                     DKMLSEFNIMFLDIDMGQYSGLSIARRVRNLQLNSLLIFVTHYVEFSLEGYEVNAFRYL
                     LKESLSEKLPIYFKEAMMQFAQKGNALKFTASGEDYVVQYENIVYLESHLRIIHLHTRH
                     PERINEYFYATMEEMEKELSPAGFLRIHKSYLVNMQHIKKLNYDRAQLSDDTILPVSQK
                     KFSEIKLRYMNWKAQQ"
     PFAM_domain     complement(11972..12241)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_196_0016"
                     /evalue="2.90E-17"
                     /label="ctg18_196"
                     /locus_tag="ctg18_196"
                     /protein_end="229"
                     /protein_start="139"
                     /score="62.8"
                     /tool="antismash"
                     /translation="YVVQYENIVYLESHLRIIHLHTRHPERINEYFYATMEEMEKELSP
                     AGFLRIHKSYLVNMQHIKKLNYDRAQLSDDTILPVSQKKFSEIKL"
     PFAM_domain     complement(12320..12646)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_196_0015"
                     /evalue="1.50E-10"
                     /label="ctg18_196"
                     /locus_tag="ctg18_196"
                     /protein_end="113"
                     /protein_start="4"
                     /score="41.3"
                     /tool="antismash"
                     /translation="ILVCDDDPTFVNQLVELINRQPKYGTSNISITGCSDPSQLNDKML
                     SEFNIMFLDIDMGQYSGLSIARRVRNLQLNSLLIFVTHYVEFSLEGYEVNAFRYLLKES
                     LSEKL"
     CDS             12859..13224
                     /locus_tag="ctg18_197"
                     /transl_table=11
                     /translation="MTQHYFGHRIQQLRKSKEWSQADLAKRLGKKASSISSYETDAKAI
                     PVDTLILLAELWDVTIDELIYGENVEILSVKSLSPEEKQLVSELIQNFAAKSGSKASTK
                     VENLELLLRIAQAMGLP"
     PFAM_domain     12886..13050
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_197_0017"
                     /evalue="1.80E-12"
                     /label="ctg18_197"
                     /locus_tag="ctg18_197"
                     /protein_end="64"
                     /protein_start="9"
                     /score="47.2"
                     /tool="antismash"
                     /translation="IQQLRKSKEWSQADLAKRLGKKASSISSYETDAKAIPVDTLILLA
                     ELWDVTIDEL"
     CDS             complement(13506..13754)
                     /locus_tag="ctg18_198"
                     /transl_table=11
                     /translation="MKREREKKYVTVDVRFSEDGRLRPLQIVFDAEHIYEIDRVKDVCR
                     RAADVGGVGDRYTCLIHGKERYLWFEKGKWFVEAFAQ"
     CDS             complement(13768..14652)
                     /locus_tag="ctg18_199"
                     /transl_table=11
                     /translation="MSIAKEISRKVKKELGITVSIGVANNKISAKLGSDYKKPDTITRI
                     EADNYEEIAYPLPVEDLLYVGTATKNKLHWYGIRTIGELAKTNPDILAGWFGKMGYILS
                     SFARGTDQTPVAKQGWHAAVKSIGNSATTPRDLLSDEDVWLMLVILSESVASRMRELAM
                     KCTVVEISVRDKDLCSFIRQRKLETPTCYSMEIAQAAFALFKASYSWAKPLRSIGVRGS
                     NLVSADSAIQLSLLSNEENRERHERLDHAVDVIRDRYGYTSLQRAIVYTDHKLGRVNPT
                     EHTIHPVGYFCSG"
     PFAM_domain     complement(13951..14280)
                     /aSDomain="IMS_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11799.10"
                     /description="impB/mucB/samB family C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_199_0019"
                     /evalue="3.60E-16"
                     /label="ctg18_199"
                     /locus_tag="ctg18_199"
                     /protein_end="234"
                     /protein_start="124"
                     /score="59.7"
                     /tool="antismash"
                     /translation="KSIGNSATTPRDLLSDEDVWLMLVILSESVASRMRELAMKCTVVE
                     ISVRDKDLCSFIRQRKLETPTCYSMEIAQAAFALFKASYSWAKPLRSIGVRGSNLVSAD
                     SAIQLS"
     PFAM_domain     complement(14551..14649)
                     /aSDomain="IMS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00817.22"
                     /description="impB/mucB/samB family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_199_0018"
                     /evalue="3.10E-06"
                     /label="ctg18_199"
                     /locus_tag="ctg18_199"
                     /protein_end="34"
                     /protein_start="1"
                     /score="27.3"
                     /tool="antismash"
                     /translation="SIAKEISRKVKKELGITVSIGVANNKISAKLGS"
     CDS             15163..15852
                     /locus_tag="ctg18_200"
                     /transl_table=11
                     /translation="MQWYERLVQERKRLGLSQDQVVAAMSKYLPAGESVGKGALCSWEG
                     GRTQPKIHHALALARVLNNADVSYLFSSESLRDGLNDAGLQKLAEFRSLLLDSPRYRME
                     IDSPKTRLIPIFLQAASAGTGQILDDDAFEEIEVDDTVPTNADFGVRLAGDSMMPRFTD
                     GQMVWVKRRDVAENGEIVMCYYDGQSYCKKLWTDGTKTELRSLNPAYKPIHVCADAPFR
                     IFGVVVG"
     PFAM_domain     15502..15846
                     /aSDomain="Peptidase_S24"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00717.25"
                     /description="Peptidase S24-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_200_0020"
                     /evalue="1.10E-21"
                     /label="ctg18_200"
                     /locus_tag="ctg18_200"
                     /protein_end="228"
                     /protein_start="113"
                     /score="76.9"
                     /tool="antismash"
                     /translation="PIFLQAASAGTGQILDDDAFEEIEVDDTVPTNADFGVRLAGDSMM
                     PRFTDGQMVWVKRRDVAENGEIVMCYYDGQSYCKKLWTDGTKTELRSLNPAYKPIHVCA
                     DAPFRIFGVVV"
     PFAM_domain     15876..16385
                     /aSDomain="SRAP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02586.16"
                     /description="SOS response associated peptidase (SRAP)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg18_201_0021"
                     /evalue="1.20E-32"
                     /label="ctg18_201"
                     /locus_tag="ctg18_201"
                     /protein_end="170"
                     /protein_start="0"
                     /score="113.3"
                     /tool="antismash"
                     /translation="MCGRYQFSAAANDDLRQIVRSVQKRCGQDELNFRIIDGDVAPSCS
                     APVLISRGDKVVGDLQRWGIPGRNGHLIINARAETVTQKGMFRRSITGRRCVIPATAFY
                     EWDSAHRPYLFTVPGSPLWLAGIYDCVEDVNCFVILTTAPNASVSKIHDRMPLTLLRDE
                     IRPWLTD"
     CDS             15876..16469
                     /locus_tag="ctg18_201"
                     /transl_table=11
                     /translation="MCGRYQFSAAANDDLRQIVRSVQKRCGQDELNFRIIDGDVAPSCS
                     APVLISRGDKVVGDLQRWGIPGRNGHLIINARAETVTQKGMFRRSITGRRCVIPATAFY
                     EWDSAHRPYLFTVPGSPLWLAGIYDCVEDVNCFVILTTAPNASVSKIHDRMPLTLLRDE
                     IRPWLTDPEVALALLARTPAPLHCQAQDGQLTFE"
     CDS             complement(16534..16689)
                     /locus_tag="ctg18_202"
                     /transl_table=11
                     /translation="MNVKKELIQIAGKIINRLGEREQSDDYFPVCPFIGYQPQRPFSQQ
                     EQTNQE"
     CDS             18025..18546
                     /locus_tag="ctg18_203"
                     /transl_table=11
                     /translation="MNLKKKIVALGMVCALALGMATSAFADYNNISYRPMRSGSYSYNW
                     LNVNRSSASISPKGKNLILWNVTTPNTDQKFNEWTKTVGGRTGTVICFADNTSLAVNRS
                     SSTGSAILWTWNNVVSFNDSALIPINRWDSPQYELKFGSSAGQYLRYASDASGARVYFS
                     ANTSNTVWDN"
     CDS             18635..19876
                     /locus_tag="ctg18_204"
                     /transl_table=11
                     /translation="MKISIIVKLSVLCLFVTSLTACGIHTPRESERGPAVTSGNETPIT
                     HVAYLDMVNQHAVSPDGLYSVCQVQLGGENLFYVDAESRQETYLCAAPNCTHDSLDCTS
                     YLPMNGEYGYGIFFFDSHLYVLQNTPIQSHGPYLMQIEPDGTNRKTVLELQDGESFLGS
                     VFGYGSSLLMEINVVDETGTWHRRLEQIDLQSGEREILLEYPTQEKQVFTLMGAAGTNL
                     IYLCSNYEQNQYFKVDLSSSDVSLEHWQDNTLGPQFDNVTSYCNVQGDYFCTYDTKTNR
                     LGYENLLTGETREFDAPALAPGETLYGLVYLFDDQFALTLDDAQNNIVLALLDSESGNL
                     TGVRYMQTKENSHTIVGDFGESIICQVSNSEQLLEGQDKEGLINELSYYSIYSIISKDD
                     FLKGIQGTEIAFPG"
ORIGIN
        1 aacgaaaata tccccaagat agtaatgttc tgtgtaagag tagaagccgt agtcttcatg
       61 gataaagtag ggaagcctta gccgaagcac gtcttccacg atatgcttca catccgtagt
      121 gggaaaacga atccgcacat aatcaaagag catttcaagg ggagtgtctg gattgaagcg
      181 ttccagagct tccgtgatgg cttcctgtaa tgcttcggac gggtgagcct tgcccgtttc
      241 aatatcgctc aggtacggac gtgtgattcc ggcagctaac gcaagtttct gttgtgagat
      301 accataaatt tcccgttttt ctttgatgtc ccgtacccat gtttcttcat tcagtgaaaa
      361 tccctcctgt ctaaaaaagc gtatgtcaac tttcagagcc ttgttgacac acgccggata
      421 tggggaaaat cccttgtgta ccgtgggatt ttgccctgtt gtttggttgt tgcctgtcga
      481 tttgtacccc tctgttagat acgaggggtt tatgctggcg tgccttgcgg cacaccagcc
      541 acagcaggtc agtccgtttc tgcggctttc gcttcgcacg ccgcctgcac tccctgcctg
      601 ctgtctgtca gtttttttat ttctttgagg aaatcgtgtc cttttgggac aaggggcgtg
      661 taaaactccg agataacgct ggttcccaca tccacatagc cacgcccttt tatctgcttg
      721 aggaagaagt cctttgtggt ttccccgaac atcattccat aacccatttc cgacatccgc
      781 cccagagcta cacggaaatt aaactggtca cggattccgt cccccagata ctttgcgtcc
      841 ggacgctggc aggcgagaat caggaagaaa ccagcctgcc gcccaagcat aacgatttgc
      901 tttaatttgt tgaggacagc ggcgttttcc tttgtgccga gcatttccat aaatgctaca
      961 tattcatcaa agataaggaa atttgcagga agccccaagt aagcgtagtt ttcccctgtc
     1021 cggtaattct ccatgagctt catgtcttcg ctgcgtttca tcatttcttc atagaaacgg
     1081 tcaatgcagg cgagcatatc ttcctttttg tagtacacat ccggcataac cgcctgtaaa
     1141 tccgcaaggt cggcgttctt cgggtctaac acggacagga cggcgttggt gcggagcagg
     1201 gcttcaatga gggtcaggat aaagtaggtc tttccgccgc cggttcctcc ggcaatgagc
     1261 atatggggga gcttgtcata ctcccaccag acattttcca tgagccggag cctgccgtcc
     1321 tttgcctgta cgtcctcaat ggagatacgg cctccaatgg tatcatagag cagggtgtac
     1381 tccacgtagg aatcctttaa ttctttatcc gtcagctcac agtacaagcc gctttccagc
     1441 tttttctcca agtttaagag ctgttcctga tatttaccca aggtgatttc cacacggata
     1501 tggagcaaac cctgtttcat ccggtaatag atttttggaa agtaagtgat ggtttccttg
     1561 gaacggctgg aagacaagtc cttgaaaaaa gcgtcctcct ttctctgctc cgattcatac
     1621 cacttgtttt ccaacaccat ccttgccagc ttttggcggt ggatgagttg ctttacttca
     1681 tccctgcggt atcgccagaa cagaagaact gctgtaaggc acaccagccc tgccacgccc
     1741 atgctgaata acaggtaagg gatatttaca tcctgtacta tctgggagag ggacacttcc
     1801 tgccagtcgg ttccggcaat ttgccggata tgaaacagca ggacaaccag caggaagaca
     1861 gggaacaggg cggcaagggc agtatggaac acaaggtctt tatccgtggg gcggatacgt
     1921 tttccacggg ggaaaagctg cttcatggga acaatcctcc tttcgctttt ctcttattta
     1981 gctgctattt tacaggggga acgtctttct tcggtgtctg gggattcatg gcagcccctt
     2041 ttttcaggac aatatcctct gctttgatgt accagtccac ctctgctccc tgaaaggtag
     2101 ccgttgccac ggtatctgcc actggattga taagttccac ctctgcgttg taatcgaact
     2161 cctttaacgg cacgctggca gggatagaaa cctgaatcat acgcccctgt cctctggatt
     2221 ttaagtcata ggtacgctcc ttgatttctt ctgataccga gccgtcttca ttctggaggt
     2281 gaacctcacg gcggagggca gaaaatttca atgccccgaa tgttgcttcc ttgtcaatca
     2341 cgattccgtt tgctaatctc atagtctgat gtcctccttt tccttatgct tttaccatat
     2401 cgtcagcgtg taaaatgtag ttggtaaagc cccttgtgcc gattttatag ccctctgcgg
     2461 tgatacgggg attgacgagc ttcacacgtt cctcaaagtc aaaatgtttt tctccggctt
     2521 cggcagggag gataaccaca atatcatccg ccctctgtac gtctgaataa aggttgaagc
     2581 ttcgggagag taccgccatg cgtccgttga ttcttctctg ttctgttttg tcttctccgg
     2641 caaactccaa gttgccgaat gtcttttcca tgttggggat aacgaatttt aattccatat
     2701 agatgtacct gtcctttctg aaataatata gttggttcga tagtttctgt tgatgttcca
     2761 tccgacagcg gaggggaacg attcttctct gtcatacaag accgcctttc ttattcatgt
     2821 atggtttctg ctattcctgc catgatgtaa tcagcacacg gcagggcgat tgcgtttcca
     2881 agtgctttgc accgtgcatt atcgctaatg ggctgtccta aatttccata tgctgtccac
     2941 ccatccggta atcccatcaa acgctcacac tctacgggtg tcaaatttcg gagaactccg
     3001 tctttttctt ctccctcata ccagaatgaa atcatattga ctgcttttgc caacagagtt
     3061 ggaaaaggtt catctggtcg tccgaaactt gtgaggaaag cagactgatt tcctgatttt
     3121 gcggcactcc gcatacgccg ttcctgaaag gggcggatga cgggtatttt cccccttgtt
     3181 ttatcaagag atattcgact ggctccggcg gtgggcagcc cgtagtctgt gcaaggcgga
     3241 ggaagcggga acatatcgcg gggcttaaat agtatttctg cggaacgctg tcctctaaaa
     3301 tctgccacaa ggaagattct ttttcttcgc tgaacaagcc ggggctttcc ccaatactgg
     3361 gcatccatga gccgccagca caggtcagtc tttccccctc gcaccatacc ggcgttagcc
     3421 catcctccag taggaggcat tgaaatttcg gtatcggaaa atgattgcag cacggctcta
     3481 aaatccatcc ggtcatttga agaaaacgct cccatgacgt tttcccaaac agcgataact
     3541 ggatataacc catttgtagc acacctcatt tcttctataa ttctgatagc ctgaaaaaac
     3601 agtcctgatt tgcttccggc cagtccctca cgctttccga ttttagaaag gttctggcag
     3661 ggcgaaccga atgtaataat gtgaacagga gagatgtttc ctccgtgtat ctttgtaata
     3721 tcccctaaat gttccatgtc tgggaagtgg cgtttggtta tggctatcgg ggatttttca
     3781 atctcgcttg cccaaacggg aataattcca ttacgggaag ccgcaagagg gaacacgccg
     3841 attccgtcaa acaggcttcc taatttaagg gcacacatag accgcctttc gttttgcttt
     3901 ttcatgtgtt gtttccattt ttctgctcct ttccagacaa taaaaaaaca ccatcaatgg
     3961 aagtccattc aatggcgttt gctgttgtct gctcatttct caaggtaaag cagaaagccc
     4021 aatagaaaaa gacgcaaatc tcaaaatgcg tctttttcca tcttcatatt cattttttat
     4081 aaaagcaccg tctgcctgct gtctgcaaag ccttgatttt actggttttc tactaccatc
     4141 cttatcaaag ccttgctaaa tcaagggttt tcggcatttt ccttttttcg ctattttgaa
     4201 aaaatggaag aaaaatccag cttgctaacg gcgtgaaggt ggcttgctaa cggaattttt
     4261 gaatttgcaa agaaagttga ccgttccttg tttgaatttt cttcagacgg gtctgctaac
     4321 acaattagca ggaaagagca aaatttgcta acgaaatcag gtatcttgct aacacggcct
     4381 aaaacccttg caaaaagtct gctaacagaa aaggtgattg gtcaatgtat catgtggtga
     4441 aaaataagaa ggggctgttg caaaatagcc taaaatgaaa aaaatgagat agacttcccc
     4501 gaaagggttg cctatctcat tttttgttgt agtctgaaac tgcaatgaac caaacacaac
     4561 aaaaagagta tagcagaaag gcggcgcagt atcaacagtt agcgctgcca atcacacaaa
     4621 atattgaaat agcggaagat gaacccgtat ttgtagccaa cgcccagctt gaggaactgg
     4681 attacaggaa actgtacaaa gcgtattcgc ccaaagggag aaaatcggca gcagaaccac
     4741 ggatcatgtt caagctattg gtgtacggat acatgtgcgg aatctactcc acacggaagc
     4801 tggagcaggc ctgccgtaag aatatcgact tcatctggtt gctgcaggga gagcgagtac
     4861 cggatcatac ttcgtttgcg cgttttcgca gtggcaaagc gaaggatgcc attgaagacc
     4921 tgttttacca gtttgttcgc cggctatggg aggaagagga gattgaatac gaggaagtat
     4981 tcatcgacgg aaccaggatg gaaagcatgg cgaaccggta tacctttgtt tggcgaaaga
     5041 gcgtaaccag acagctggcc aaggtgaaag agaaagccag ggaattgttt taccaatacg
     5101 gcggagaggg caacctgact gtcggcaagc tgcaagccct tgcaaagagc cttgtgcccg
     5161 aaggaggaga gatggtacac gggacaggca gaagaaaacc gttctggcag cggcaatacg
     5221 aagaaattga ccggctggtg gtgcgctgga agaaatacga aaggcagctg tttgagatgg
     5281 gttgccacag gaacagcctt tccaagacgg acaaggatgc caccttcatg cggatgaaag
     5341 aggaccacat gggaaatggt cagctcaagc ccgcatacaa tgtgcagctg gcagtaaaca
     5401 gcgaatatat taccggtgtg gcagctttct ccaattgcac agacagcgga acgctcatcc
     5461 cattcctgaa tcatattcag agaatgcaag gccgcagtta ccgggacatt gtggcagatg
     5521 cgggctacga aagcgtgggc aactatctgt atcttgcctc tcgtggacag aactgctaca
     5581 ttaagccgac caattaccaa accagaaaaa cgaggaaata ctgtgaacag ctctggcgcg
     5641 cagaaaacat gcggtatctg gaagatgaag actgctttgt ctgcgctgcg gggagaaaac
     5701 tgcgctttta cagatcctgt tcacaggaga gcaacggtgt agttaccaca tacaattatt
     5761 accaatgtga ccagtgtacc ggatgtccgg ttcgcaagca gtgtaccaaa tcccaaaatc
     5821 cggattttcg caaagaagtg aaaatctgcg aggagtttgc ccaacacaga gcgcaagccc
     5881 acgaaaatct gctcacagag cggggcgttc ttttgcgcat gaatcgctcc attcaagttg
     5941 agggtgcttt cggcgtatta aaaagcgacc gccagttcaa acgcttcctt atgcgaggga
     6001 aaaccaacat ctctctggaa ctgtttttgc tgtgtctggc ctttgatctg gacaagtact
     6061 gctccaaatt gcgacaggac agacggaaaa cacatctttt tccgctcaaa aaagagtaga
     6121 tatttatgac atctgaaaaa acacaaaaag ccgggcttcc tcattgcgga aagctcagct
     6181 ttgctgcgcc tacttaagat gatttggaga ctatttctcc taaaattctt gaaaaagtct
     6241 cttccgatcc tgcttttcgc aaaaagtggg ggctgttgct caacttccgt tttgcaacag
     6301 ccccttcgca gctcataatg cgctgaccag ttgctttaag agtgcggcgg tttctgggtt
     6361 tttcagcagt tctagaattt tggctgtgtc gctcatggaa tcttcctctt tttgtttgat
     6421 ggctggttgc tccggcgtaa cggaagcagc agcgggagaa gattgcttag gagcataaaa
     6481 ggcagcttcg aatcgttggg cgttcaggca gcgatcttcg tcaataatgt gggaatacac
     6541 atccgcgacc atcttcattt gtgcgtggcc tgagtcaccc tgtacagact tcatatcacc
     6601 gccgttcaat ttcagtttgt aggtgatact ggaatgacga agggaatgaa agactacatg
     6661 aggaagacca tgatcttcaa tcaacttact gaatgcccgg ttgatgatct gactttccat
     6721 ggggcgtccg ttgctggagc aaaagactaa atcattatcg atgtactcgt cgccgaacag
     6781 atccatcagt tcggcgattt cttctttacg cttcacaagc atctgggcaa ctgtctgggg
     6841 aagatagacg cgccggatac ttgttttggt tttcggctct ttcagaacca gagcggtatg
     6901 ggtactggca atacagggag gaaactttcg tactacgcct ttgtcactta aatcgtccag
     6961 agcgccacgg gtgacacgct gaagttcttt attaatgaag atactggcgt ttccagcctc
     7021 aatgctttgc ggagagatgt ccacacagtc ccaagtcagc ccaagcaatt cgcccatccg
     7081 cagagaacag gagaacgcca gattgatggc caatgaaaga atggggtcat cacatacctc
     7141 gagagctttt gcaagcatat ccggactcca aatctctcgt tttttatact ctgcttttgg
     7201 aagagttgca ttcagaaccg gattgcgtgg gatcatttcc caacgcaccg cctgattgaa
     7261 tgcgttacgc agcagcttgt gaatctcacg aacagtgtgt gcagaaagat attcacttgt
     7321 gggctttctg ttgttgatag aaacggattt cacattcagc aggtcacggt agtatttgtc
     7381 catcattcgt ggggtgatgt ctgccaaaca aagatcaccg atgattggaa tgatgtaatt
     7441 tcgcatcaga cctttccggc tttcgtatgt agacatagcc caggtgttta ctccataaat
     7501 ggacatatac tcgttgagaa gatctgccag agtttttgcg gtgggaacga taaagtttcc
     7561 ggtttcctgc tcatattcga tttgagtttt cctcttttta gcctctgcgc tggtgtcaaa
     7621 ggtttcccag cgctgccgtc gcttgccatg ttcgtcaatg taggcgtaca ccactgaata
     7681 cttgctttta cgttttacaa tggatgccat gattactctc tccgttcaga acatttctta
     7741 tagcggtcct gactgtcgta ccagcattca aaactgtctc gcattacccg gatacgacga
     7801 tcaataatcg tggtttccag atgtacccgt ttgaccagtt cgtaagccgt tgcagaatga
     7861 atacctagca tctcagcaag ctccgggaca gaaagggtgg tgtctctcca tttggtacca
     7921 ggtggagttc cgtctacctt tttataatgg aactgtccag agtaccaatc ttcgaaactg
     7981 tccagcatga cacgcattcg accggcaacc tgtatggtag tgaaatagtt tttcttgacc
     8041 agccagtagg attctacctt tttcaggcca agcattttgc ccatttcacg aaccgaaaca
     8101 cttttctttg ttttagtggt ttccattttg ctcctcctct tacggttgat gggtgttttg
     8161 cgtgatccaa ttgtaagaga agtgcggaga aaaagtaagg atgccgataa ccgaatcgac
     8221 acccttgaca tcatacggca ttttgatcca gccattcatc aaagctcttt ttggaaatac
     8281 ggatgtgacc gccgactcgc acactgcgga aaagctcctg ctttaccaaa ttgtatgcag
     8341 tggggcgact cacacccaga atatcctgaa tttcatcaac ggtgtaggtt cgcttttcaa
     8401 agcagacggg attttgctcg ttgatacggt tcaattccgc aattcgttct tgaaacatga
     8461 aacagactcc ttgttagttt atggggctga taatgaaggt aatagatcag ctcaaacagg
     8521 gaaatcgtgc gatatgattt gcagataata atgttattgg tagttcgaat gcaactatca
     8581 atgcgcttga ttccacatag gcggcgacca ccgcaaactg gtgatcgcct gatatctgga
     8641 atcaagagtc cagataaatg ttcattgaaa aatgaactca ttgaccgggc cgttggctga
     8701 cccctcttcc tgcccagccg gaggcagtcc cgccacattc ttgcgatagt gctgcgggga
     8761 gtatcataat acgctgccct ttctttgcat caggtggggt gccatgccac cctgacagcc
     8821 actgggaatc gctcaccaaa aaagggttat ggcgtcagtg ctgtccgtgc ttgccgtcgc
     8881 tccgtgggtt gcggcaaggc aggttctatg tcagtcaatg aagaaaaata ttcagttttc
     8941 aaggttcccg gagagggggg gtaaaaaaag tcctctcata atataaggac attttttggc
     9001 cattcgtagg gtaggaaaag taaaaaaata gaaaatattt gaaatttgac gcaaaacagt
     9061 atcagatata cgagttggcc acaagaattt tagagattgt tcttaaagcc tgttcgatgc
     9121 tgtcttgtat agatgctttt gaaataccct ccgcatgggc gatttcagaa atactcatac
     9181 gctggaatag gtgtgcggat agccttcgat attgcttttc agacaagtgt tccattgcct
     9241 gataaagtgc cattcgaagg tgcttttgtt cgtaaagcac cataggagag ggctccgatc
     9301 caagaatgtg ggactccaaa ctgggatctg catccaacga ataatatgct ttgtttcgct
     9361 ttttcttttt ataatatgct ttttctgtgt tttctgattt gcgaaagacc tctgcaatat
     9421 catcagaaac agtgatgtag aaatcattgg gatagataga aggataatat tcgcgaagat
     9481 taatgttttt cataaaaaga cctccagagt caaaaatccg ttcaaacttg gcgtaatatt
     9541 tgattctgga ggcccacgag gaaataaaaa aaggcggaat agcctgaacc agttgaacgg
     9601 ttcaatgact attccgccac caggaaatga aaaagaaagt tgttcactat gtaggaaaaa
     9661 atgcaaattc tacagattta tttgaaaatt gatataaata aaaagcccac tattgtagaa
     9721 aacttaattt caacaatagt gggcttttaa agtggaaaaa tcgctaattt tcaaaaattg
     9781 aatatcagga tgatgaatgt atactcagct gtttttagga tcgattttat cgataggggg
     9841 ggtctttaaa agcggtgcgt ccggccgatg cggttgatat gcccagacat gagggcagga
     9901 tgcatacttg ttggactcgt gttcaatcga tttttgaacg agtgacttca gaatagtgtg
     9961 tacggtcttt tttgtgctgt ttttcatata aaattcctcc tcattggatt ccaaatccaa
    10021 ggtttgcgat aactaaaaga aatgcgacta cattgagaga cataatgaga catctaccca
    10081 aaattggaaa agtgaataat attatgaagg ttaccagaca aaatataacc agtgaaacat
    10141 gcattttgtt gcgagctatt atcatttctt cttcagtaaa atggatttga ctgttgttaa
    10201 atggacctaa ataaagaatg ataaaaatag aacagaaaaa ggtaagatat gcaataacgt
    10261 tgtcaaaata atagaataaa aatagggatg aaagttccaa aagagtagat gtcataaaac
    10321 atccgataaa agttttggaa tggaatccat ttattctagg acgtaaatat agcatgccaa
    10381 tatttagagt gatgacaacc tcaattggag caataaagca tcctatcaaa attaaaatgg
    10441 gcaaggaaaa gagagttgtt aaccggcttt ctaggatata ggtgaaccat tcgctttgat
    10501 aaggttcgat caatccaatc cggagaaagt agtttgtaat cttatttgcg gcggtttgca
    10561 tcccataatc accccaccca cacacttttt actaatcata taggaaaatg agtgagaaat
    10621 actcattttt gcatcaaaaa acgagtataa tgttatgaaa gaggggtgtt ttgaatctca
    10681 gcataggcta agaaccatcc gttttgataa tctaagccaa agtatgaatc gtatttgtta
    10741 agagtagacc gtacattttg caaaccataa ccgtgcaaaa gagtatttgg ttttgtggta
    10801 ataaccatgt tatcgcagac ttgtacagtt tcagaacggt tgcgaattga aaagaaaaac
    10861 gcgtcttcta gaagagcttt cacgtgaatt tgacgctcct ggatagggag tttctcacag
    10921 gcctcgatgg cattatccat taaattacta ataatcacag taaggtctac cgcatcaatt
    10981 agaagaggag aaagatcatt tacagtgaat tgaacatcaa tgttatgttt tttggcaatc
    11041 aacgcttttt ggttcaaaat tgcatccatt gcagaattgt gagtgtttac aagaagaata
    11101 cgttctgttt gttctgcacg tagttgagtg atatagttag ccgcttcctg aaaagacttg
    11161 ttttccagta aagaatccaa catttccaga tgagcacgaa aatcatgtgt tagtttacgt
    11221 tgtgctgtat ttgataggct gagtgcttca atgccttcag actgcacttt gatttgtgca
    11281 tgaagcaata gagattcttc tcgaaagtga gaagttcttt caatccaact gaccagtaac
    11341 aaagaagcga tgtttactat agtgataaat gcagcacata cagaaagcgg gacacactcg
    11401 atttgatcat gttgaaagca tgagtttagg taaaattcca tcataataca gacaaaagac
    11461 agaacagtgg gaatagagta ccaattccaa ttagtggttt cggtacactt gagctttctc
    11521 gatcgatgga atgcgaaaca aaaaataagt ggcaatccgt gagaaagcat acctaggaga
    11581 aggtacacaa taaagtggga ttgtaaagtt gaatagtgcc aaccgctgaa cgccaaaaaa
    11641 cttgtgaaaa caagattatc gatggtacat ccaatggagt aaacaattat agagaaaaaa
    11701 acagagtaag ctttggaagt tatatgtaaa aacgagttta taagtgcgaa aatgagaata
    11761 cttacgatag gagtatatgt ggatggggaa aatgttaaca gaatagtgcc agcaattgtg
    11821 aagataggaa atagtaaaaa ccgccggaaa ctatggctcc tttttgggaa aaaagaatcg
    11881 aagaataaat gtgaatagag aagatcgatt gataaccata gggcagtaag aagaagtgtg
    11941 ttcattgttg agccttccaa ttcatgtatc ggagtttgat ttcggagaac ttcttttggc
    12001 ttaccggtag gattgtatcg tccgatagct gcgctctgtc atagtttagc tttttgatat
    12061 gttgcatatt gacgagataa cttttgtgaa ttcgaagaaa tccagctgga gatagttctt
    12121 tttccatttc ttccatagtt gcatagaagt attcgttgat ccgttcaggg tgacgagtat
    12181 gaagatgaat aatacgtagg tgactctcaa gatagacgat attttcgtat tgtacaacgt
    12241 aatcttcacc gctagctgtg aatttgagag catttccttt ttgtgcaaat tgcatcattg
    12301 cttctttaaa gtaaatggga agtttttctg aaaggctttc ttttagaaga taacgaaagg
    12361 cgtttacctc ataaccttcg aggctgaact ctacatagtg tgttacaaaa atcaacaagg
    12421 agttcaattg taaattacgt acgcggcgcg caattgaaag cccactatat tgtcccatgt
    12481 caatatcgag aaacataata ttaaactcag aaagcatttt gtcgttcaat tgactagggt
    12541 cagagcaacc ggtgatagaa atgttactag ttccgtattt tggctggcga ttaatcaatt
    12601 ctaccaattg attcacaaag gtcggatcat catcgcaaac taatattttt acagtcatag
    12661 ttcgtactcc tacttctttt aagatcagac gagtttttac atctgtgttc aaaataggtc
    12721 ttcctttcaa aattgtcaat aaatatgacc agaataacac catgagtgtt atttgattat
    12781 aatacttcac ttaaagtgga taatcaacaa ttattatgaa agaaatcgaa aatttgagat
    12841 atggggtaaa ggcttaggat gacgcagcat tatttcggac accgtattca gcaattgcgg
    12901 aaatcgaaag agtggtcaca ggctgatttg gcaaagagat taggaaagaa ggcttcctct
    12961 attagcagtt atgaaactga tgccaaagca attccggttg atacactaat tcttttagca
    13021 gaattatggg acgtgacaat cgatgaattg atttatgggg aaaatgtgga aattctgtcc
    13081 gttaagagcc tttctccaga ggaaaagcaa cttgtttcgg aattaattca aaactttgcg
    13141 gctaaatctg gaagtaaagc aagcacaaaa gttgaaaatc tggaattgtt gcttagaatt
    13201 gcacaagcaa tggggttacc atgaatgtga gtttgtcaaa gactcttggt cgactatacc
    13261 cccattgagt cgttacagat tgtgttgtca ccataaaaag tctacgtata gaaatattta
    13321 gtttagcggg aatggcacaa attgagcagt gccattcccg ctttttaggt tcgaggcagc
    13381 agtggaatag aaaacaaaga gcaacaccaa ttgcatatgg tgttgctctt cacgaacttc
    13441 taaattatca ttcccggtgt cgtttgcttg tgtgttattt ttacatctgt aaaagattaa
    13501 atacactatt gggcgaacgc ttccacaaac cattttcctt tttcaaacca taggtagcgc
    13561 tccttaccat ggatcaagca ggtatagcga tcgccaactc cgcccacatc tgcggctctt
    13621 cggcatacat ctttgacccg atcgatttca taaatgtgct ccgcatcaaa aacaatctga
    13681 agaggacgga gccgcccatc ttctgaaaag cgaacatcga ctgtcacata tttcttttct
    13741 ctctctcgtt tcattcagtg tctccctcta cccggaacag aagtagccta caggatgaat
    13801 tgtatgttca gtaggattaa ctcttccgag tttgtgatcc gtatacacaa ttgcacgctg
    13861 caggcttgta tatccatacc gatcccgtat gacatccacg gcgtggtcca aacgctcatg
    13921 acgttcgcgg ttttcttcgt tagagagcaa agagagctgt atagcagaat ctgcagaaac
    13981 cagatttgaa ccacgcacac cgatgctgcg caatggcttt gcccaggaat aactggcctt
    14041 gaacaaagcg aaagcggctt gggcgatttc catgctgtag caggtgggcg tttccagttt
    14101 tcgctgccgg ataaaactgc aaagatcttt atcgcgaaca gagatttcga caacggtaca
    14161 tttcattgcc agttctcgca ttcgggatgc aacgctctca gacaggatca cgagcataag
    14221 ccaaacatcc tcatcactca gtaggtcgcg cggcgttgtg gctgaattgc caatgctctt
    14281 tacagcagca tgccaccctt gtttggcaac tggagtttga tcggttccgc gggcaaagct
    14341 ggagaggata tatcccattt tgccaaacca tccggccaat atgtcgggat ttgtttttgc
    14401 caactctcca attgtgcgga taccatacca atgaagtttg ttctttgtgg cggttcccac
    14461 atacagcaga tcctcaaccg gaagaggata ggcaatctct tcataattgt cagcctcaat
    14521 tctggttatg gtgtcaggtt tcttgtagtc actgccgagt tttgcactaa ttttgttatt
    14581 tgccacaccg atggaaaccg tgatgcccaa ctctttcttg accttacggc tgatttcttt
    14641 ggcaatgctc attccatttc cgaacaggcc gcagctcccc gtaacatcca gccaactttc
    14701 atcaaggcca aagggttcaa cctgatcagt gtaatactca aaaatttctc gtacaaaacc
    14761 actgtagcgt acatactcgc tataatgcgg gggaacaaca tatcaagtct tcacatcgct
    14821 gcttagcctg ccatatagcc atcccggttt tgacacccat ttttttggcc ggatagcttg
    14881 cggtgagtac gatgccatgc cgtgcctcgg gatcaccaca cacagcaatt cgcttgccgc
    14941 gatactcagg gtgctcctgt gcctctaccg aagcatagaa gcaattacag tcgcaatgaa
    15001 gtatttgtct cagctgcacc aaactcacct ccctgcagtt tcattataaa tctacaaaac
    15061 agataaatca atggcataaa atgattgttt tgtagatttt ttgaagaagc agccttgtca
    15121 gcattatcag aaagctgtat aatgtcattg aggtgataca gcatgcagtg gtatgagcgg
    15181 ttggtacaag agcgcaaacg cctgggacta tcgcaggatc aggttgttgc agctatgtca
    15241 aaatatctgc cggcaggtga gagcgttgga aaaggagccc tgtgctcttg ggagggcgga
    15301 cgcactcagc ccaaaattca tcatgcgctg gcactggctc gcgtcctcaa taatgctgat
    15361 gtgagttacc tgttcagttc ggaatctctc cgtgatgggc tgaatgatgc ggggctccaa
    15421 aagctcgctg aattccgaag tttattgctg gattcacccc ggtaccgaat ggagattgat
    15481 tccccaaaaa cacgactgat acccatcttt ctacaggctg cctcagccgg tacaggtcag
    15541 atactggatg atgatgcatt tgaagagatc gaagttgacg atacggttcc gacaaatgct
    15601 gatttcggtg tgcgtttggc gggcgatagt atgatgcctc ggttcacgga tggtcagatg
    15661 gtatgggtca agcggcgaga tgtggcggaa aatggcgaga tcgtcatgtg ttattatgat
    15721 ggacaaagct actgcaagaa gttgtggaca gatggaacga aaacagaact tcgttcattg
    15781 aaccctgcat acaaaccgat tcacgtctgc gccgatgcgc ccttccgtat ttttggcgtt
    15841 gtcgtgggat aaggtttata aggaggtgca gcgctatgtg tggtcgatac cagttcagtg
    15901 ccgcagcgaa tgatgatcta cgacaaatcg tgcggagtgt tcagaagaga tgtgggcagg
    15961 acgaactgaa cttccgtatc atagatggag atgtagcgcc ctcatgtagc gctccggtgc
    16021 ttatttcaag aggagacaag gtcgtcggag atctgcagag atggggtata ccgggacgga
    16081 acgggcatct tatcatcaac gctcgcgcag agaccgtcac tcaaaaaggt atgttccggc
    16141 gcagtatcac cgggcgccgc tgcgtaatac ctgctactgc attctatgaa tgggattctg
    16201 cacaccgacc gtacttgttc acggtgccgg gcagtcctct ttggcttgcc ggaatatatg
    16261 actgtgtgga ggacgtgaac tgttttgtta ttttgaccac tgctcctaat gcttctgttt
    16321 ccaagatcca cgaccggatg ccactgacac ttctgcgaga tgagatcaga ccttggctca
    16381 ctgatcctga agtggctctt gcccttttgg cccgaactcc tgcgccacta cattgtcagg
    16441 cgcaagatgg tcaactgact tttgaataga atcataaaaa acggcgagct gctccataga
    16501 aagagcagct cgccgttttt gcgagtgtgg agactattcc tgattggtct gttcttgctg
    16561 gctgaaggga cgctgcggct ggtagccaat gaaaggacaa acgggaaaat aatcgtcaga
    16621 ttgttctctc tcgcccaagc gattgatgat tttccctgca atttggatga gttccttttt
    16681 tacattcatg ataatcttct ccttttctga gttaatttgg cggcgattac agaaagagct
    16741 gcaattccat acccaataat accataagca ctaatatgaa aatcatagta tctgtgccaa
    16801 gaaataaagc gcaattcgtt tcagttgttc agcgcgcaag aatcgccgga cttctatatt
    16861 gtggaattgg atttgaattc gtttgaagag aaggttgtgt ttagcacagc tgacatcttg
    16921 gataacagtg ctatcaaaca agcgataatg tatcctttga cctcatactt ctttttgagt
    16981 tcggactcgt tatatattgc atcagataaa ctgtgggaaa tcgatatgcg tacaggggaa
    17041 ttgaatctgt tgccaatcga gtgtaactat ggaaatattt cgtatgacgg aaaatacatt
    17101 tattatattg gagacgattc gaaactatat agatatagca taaagaagaa ggaaaacgat
    17161 cctattgatg gagtaactgc aaaagatttt ttcttgaatg agagctatgt gtgctattta
    17221 aacagacttg atgaagataa aatctatctt tactcactcg aaacgcgaaa aagtacaaaa
    17281 attatcaatg catcagcaac gagcattttt tttgagaaaa gggaagatag tgtttctttc
    17341 aaaagaagat gggcttacgt attgtgcgga aataaatggt acaaacatag taagatataa
    17401 agatgcaatt taggataaaa gcaagtaagc taaaatgagg gtttgtaaat gatttactaa
    17461 cgatcagata tggcttctat ttttaagtga agtcaggaaa gaataacaac gaaaaggcaa
    17521 acgcacttgg atgattccac tggcgcgttt gccttttatt atatcaatgt aaattgtaca
    17581 ttgcgaaaat caaaaagcag ataatatagc ttgaattcta ttgatgaatg caaagttatc
    17641 tgaatattct cgtagctcca ccctttcggg gggagctctt ttatatagtg cagaagcgat
    17701 aaaaatttgt ttatcaataa ctgcatagtg ccttttcatt ttcgggtgat aagacagtgt
    17761 ggaaagtctg tgaaacagca actcgtagtt tgtgacaatt atcttgttct tcgttacagt
    17821 tttgtggaaa aaatgtgaaa atggtaatat actacaaaca aagaagaaat agatagataa
    17881 ttttagctga aaagcaaacg tgtaaggaaa ttaagtagta aatcaccggt gatttttgaa
    17941 acgttccgcc gcaccgcccc cggccagggc ggcacggtgg aaaacagcgg ttgtttcata
    18001 aaaacaaaat ggaggtttta cagtatgaat ctcaaaaaga aaatcgttgc cctgggtatg
    18061 gtttgcgctt tggcgcttgg catggcgact tcggcgtttg cagattataa taatatcagt
    18121 taccgaccca tgagatcggg ttcttatagc tataactggc taaacgtcaa tcgaagtagt
    18181 gcaagcatta gtccaaaagg aaagaatctt attttgtgga acgttacaac tccgaacaca
    18241 gatcagaaat ttaacgaatg gacaaaaacg gtaggaggca gaacgggtac tgtcatttgc
    18301 tttgccgata atacgtcgct tgcagtgaac aggagttctt ccacgggcag tgcaatcctt
    18361 tggacatgga ataacgtagt aagtttcaac gattcagcat tgatccccat caaccgttgg
    18421 gattctccgc aatatgaact gaaattcgga agctctgctg gccaatatct cagatatgcc
    18481 tccgatgcat ccggagccag agtctatttt tcggccaaca cgagcaatac cgtatgggat
    18541 aactgattat tgctattatg atttaagtta taactgcaag gcggaactgc gcaggtgttt
    18601 cgccttgcag catactattt aacagaggaa tcctatgaaa atttcaatca ttgtaaaatt
    18661 aagcgtactg tgtttgttcg ttacgtcgct gacagcctgt gggattcata ctcccagaga
    18721 atcagagagg ggcccggcag tcacttctgg taacgaaacg cccatcaccc atgtggccta
    18781 tttggatatg gttaatcagc atgcagtttc tcccgatggg ctgtattcgg tatgccaggt
    18841 ccagcttggt ggcgagaatc tgttttatgt ggatgcagaa tcccggcagg agacctatct
    18901 ttgcgcagca cccaattgca cccacgattc tctggactgt acgtcctatc tgcccatgaa
    18961 tggagaatat ggctatggca tttttttctt tgacagtcat ctgtatgttc tccagaacac
    19021 tcccatacag tcccatggcc cctatctcat gcagatagag ccggatggga ccaaccgcaa
    19081 aaccgtgctg gaattgcagg atggcgaaag ttttctaggt tctgtgtttg gctatggttc
    19141 atcccttttg atggagatta atgtagtaga tgaaactgga acctggcatc gtcgcttgga
    19201 gcagatcgac ctgcagagcg gcgagaggga aatcttgctg gaatatccca ctcaggaaaa
    19261 gcaggttttc accttgatgg gcgcggcggg tacgaacctg atatacctgt gttccaatta
    19321 tgagcagaac cagtatttca aggtggacct ttcctcttcc gatgtttcgc tggaacattg
    19381 gcaggacaac accctcggcc ctcagtttga taacgttaca tcctattgca atgtacaagg
    19441 agactatttc tgcacatatg acaccaaaac gaaccgcttg ggatacgaaa accttctgac
    19501 cggtgaaact cgggagtttg acgcccccgc cctcgcccca ggcgaaacgt tatatggttt
    19561 ggtctatctt tttgatgatc agtttgcatt aacactagac gatgcgcaaa ataatattgt
    19621 ccttgcgctt ctggattccg aaagtggcaa tctaacaggt gtgcgttata tgcagacaaa
    19681 ggaaaacagt cacacaatcg taggcgattt tggggaatct atcatctgcc aggtaagcaa
    19741 tagcgagcaa ctgttagagg ggcaggataa agaaggcttg attaatgagc tgagctatta
    19801 cagcatctat tcaatcataa gcaaggatga ctttttgaaa gggatacaag gcactgaaat
    19861 tgctttccct ggctaataat cttctataac gccaccgaga attgtatgct gttttagtgt
    19921 acagttaatt ttatacttct atccgggaga aagcaaaaaa gaaaattcta tcccaagcga
    19981 aaaactgtaa cgaagtgtaa gaattcaagg aacgctacat tcttacttaa tttgaggtga
    20041 accatccatg acccaccata cgaatccagc cccttgcctt gcggtggaaa atctgaaaaa
    20101 aagctatctg attcggggtg gcctttttgg ccgccccgcc acaaaaaaaa aggccttggc
    20161 cggggtgagc ttttccctcg gcccgggcct ttacggcctt cttggcccca acggagcggg
    20221 caaatccacc ctcatcaaca tcatcaccgg cagcctgaag gcggacggcg gcaccgtgca
    20281 gtggtgcggc aaaaacgccc aggcgctgga catccgcttt cgccgggtgc tgggctatat
    20341 gccccagcag cagggccttt acgacagcta caccggccgc caatttttgg cctacatgtg
    20401 cgctttaaaa gaaattccaa gcaaagaggt gccggagcag atagaacaag tggcggaatg
    20461 ggtaaacctt tccggcgaat tggacaagcg tctggccgcc tattccggcg gcatgaagca
    20521 gaggcttttg ttagccagcg ccctgcttgg cgacccgaaa c
//
