LOCUS       NZ_CP007044.2          10780 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP007044.2 Chania multitudinisentens RB-25 chromosome, complete
            genome.
ACCESSION   NZ_CP007044
VERSION     NZ_CP007044.2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:10:23
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 111326
            Orig. end    :: 122106
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10780
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[116326:117106](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5780)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     cand_cluster    1..10780
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10780
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="2"
                     /rules="AfsA"
                     /tool="antismash"
     CDS             complement(566..1801)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 86.3; E-value: 2.8e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_84"
                     /transl_table=11
                     /translation="MHANNILKNTMLDSELSSLMISVIGVVLSVGSVYITQLIFQEISA
                     SFHVDVLDARYSFSVSCFIYAISFFIFGPLSDRVSAKSLSLFGCAGVIICLFICLYITR
                     YNIFLLAMALLGFFAAAVPAALFSYTAKNTEAYKLPRAMGLMISASIVGIIFSRSIIGI
                     LSDHFSWRMAFSMYAALVIVSMLLIIIGLKENVTVRHNHKKLSDVYINAIKILMDRKIV
                     LFLSLGFLLFFSYLGLSSFLTYYLKGAPFNLSSTALGWLNFVGISAVGGAFISARLAMS
                     IDKRKILITFLCGVSVSILVIAFGSNIYIVAFGIFSFFIFVFGIQPIIMSIINQLVDIS
                     SKGTISSLYLLSCLAGGSFGTYILGLVWSSMHWLGVVLICVSVSVINIVLAINYIGKYT
                     ASSAINPIRGSK"
     PFAM_domain     complement(722..1732)
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_84_0048"
                     /evalue="7.10E-31"
                     /label="ctg1_84"
                     /locus_tag="ctg1_84"
                     /protein_end="360"
                     /protein_start="23"
                     /score="107.5"
                     /tool="antismash"
                     /translation="IGVVLSVGSVYITQLIFQEISASFHVDVLDARYSFSVSCFIYAIS
                     FFIFGPLSDRVSAKSLSLFGCAGVIICLFICLYITRYNIFLLAMALLGFFAAAVPAALF
                     SYTAKNTEAYKLPRAMGLMISASIVGIIFSRSIIGILSDHFSWRMAFSMYAALVIVSML
                     LIIIGLKENVTVRHNHKKLSDVYINAIKILMDRKIVLFLSLGFLLFFSYLGLSSFLTYY
                     LKGAPFNLSSTALGWLNFVGISAVGGAFISARLAMSIDKRKILITFLCGVSVSILVIAF
                     GSNIYIVAFGIFSFFIFVFGIQPIIMSIINQLVDISSKGTISSLYLLSCLAGGSFG"
     CDS             complement(2000..3175)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124:acetyl-CoA acetyltransferase (Score: 507;
                     E-value: 4.8e-154)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_85"
                     /transl_table=11
                     /translation="MEDIVIVGAKRTAIGSFQGGLSTVPATELGTAVIKDLLQTYNLKP
                     ENVDQVIMGQVLTAGCGQNPARQAALNAGLPNNVCALTINKVCGSGMIAIQLAIQAIRH
                     GDAEVIIAGGQENMSLSPHILLSSRQGVRVGNSNIVDSMVNDGLTDAYNGYHMGITAEN
                     VADQYSISREEQDAYSIRSHQKALAAIEEGKFKAEISPVTVIHKKGSQVIDTDEGPRVT
                     EAARLAKLKPAFHSQGTVTAGNASSLNDGAAAVIVCSASKAKELGLTPLVKISAFANTG
                     ICPSIMGVAPISAITQCLEKINKEISQIDLFECNEAFAAQALAIKRTLAIPKEKINING
                     GAIALGHPIGASGCRILVSLIHQLSARNLKNGIAALCVGGGEGLAMAVARV"
     PFAM_domain     complement(2009..2371)
                     /aSDomain="Thiolase_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02803.20"
                     /description="Thiolase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_85_0050"
                     /evalue="6.20E-43"
                     /label="ctg1_85"
                     /locus_tag="ctg1_85"
                     /protein_end="389"
                     /protein_start="268"
                     /score="145.5"
                     /tool="antismash"
                     /translation="TPLVKISAFANTGICPSIMGVAPISAITQCLEKINKEISQIDLFE
                     CNEAFAAQALAIKRTLAIPKEKININGGAIALGHPIGASGCRILVSLIHQLSARNLKNG
                     IAALCVGGGEGLAMAVA"
     aSDomain        complement(2012..3160)
                     /aSDomain="TIGR01930"
                     /aSTool="tigrfam"
                     /description="AcCoA-C-Actrans: acetyl-CoA
                     C-acyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_85_0014"
                     /evalue="1.60E-141"
                     /identifier="TIGR01930"
                     /label="ctg1_85"
                     /locus_tag="ctg1_85"
                     /protein_end="388"
                     /protein_start="5"
                     /score="469.6"
                     /tool="antismash"
                     /translation="IVGAKRTAIGSFQGGLSTVPATELGTAVIKDLLQTYNLKPENVDQ
                     VIMGQVLTAGCGQNPARQAALNAGLPNNVCALTINKVCGSGMIAIQLAIQAIRHGDAEV
                     IIAGGQENMSLSPHILLSSRQGVRVGNSNIVDSMVNDGLTDAYNGYHMGITAENVADQY
                     SISREEQDAYSIRSHQKALAAIEEGKFKAEISPVTVIHKKGSQVIDTDEGPRVTEAARL
                     AKLKPAFHSQGTVTAGNASSLNDGAAAVIVCSASKAKELGLTPLVKISAFANTGICPSI
                     MGVAPISAITQCLEKINKEISQIDLFECNEAFAAQALAIKRTLAIPKEKININGGAIAL
                     GHPIGASGCRILVSLIHQLSARNLKNGIAALCVGGGEGLAMAV"
     PFAM_domain     complement(2393..3166)
                     /aSDomain="Thiolase_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00108.25"
                     /description="Thiolase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_85_0049"
                     /evalue="9.60E-100"
                     /label="ctg1_85"
                     /locus_tag="ctg1_85"
                     /protein_end="261"
                     /protein_start="3"
                     /score="333.3"
                     /tool="antismash"
                     /translation="IVIVGAKRTAIGSFQGGLSTVPATELGTAVIKDLLQTYNLKPENV
                     DQVIMGQVLTAGCGQNPARQAALNAGLPNNVCALTINKVCGSGMIAIQLAIQAIRHGDA
                     EVIIAGGQENMSLSPHILLSSRQGVRVGNSNIVDSMVNDGLTDAYNGYHMGITAENVAD
                     QYSISREEQDAYSIRSHQKALAAIEEGKFKAEISPVTVIHKKGSQVIDTDEGPRVTEAA
                     RLAKLKPAFHSQGTVTAGNASSLNDGAAAVIVCSAS"
     CDS             complement(3263..3922)
                     /locus_tag="ctg1_86"
                     /transl_table=11
                     /translation="MRQTAFYDVDDTLINIKSMFDFFQFWASENGLISQQEQFDSQFSV
                     LARKMSSREELNRAYYRFFKGVPLLKIEQCAERWFKNSFSNTEIFISYTLKSILAHRVL
                     GHNIVLVSGSMTPLLKPIAQLLGITDILCTKLATDQSGVVTGEILETQTIGEGKAIVIR
                     QYALENDINLSACFAYGDDVSDIPMLACVGHPICIGEGTALSHYASNNNWPIVRVE"
     aSDomain        complement(3326..3910)
                     /aSDomain="TIGR01490"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IB-hyp1: HAD hydrolase, family IB"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_86_0015"
                     /evalue="9.80E-44"
                     /identifier="TIGR01490"
                     /label="ctg1_86"
                     /locus_tag="ctg1_86"
                     /protein_end="199"
                     /protein_start="4"
                     /score="148.0"
                     /tool="antismash"
                     /translation="AFYDVDDTLINIKSMFDFFQFWASENGLISQQEQFDSQFSVLARK
                     MSSREELNRAYYRFFKGVPLLKIEQCAERWFKNSFSNTEIFISYTLKSILAHRVLGHNI
                     VLVSGSMTPLLKPIAQLLGITDILCTKLATDQSGVVTGEILETQTIGEGKAIVIRQYAL
                     ENDINLSACFAYGDDVSDIPMLACVGHPICIG"
     aSDomain        complement(3353..3910)
                     /aSDomain="TIGR01488"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IB: HAD phosphoserine phosphatase-like
                     hydrolase, family IB"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_86_0016"
                     /evalue="4.90E-26"
                     /identifier="TIGR01488"
                     /label="ctg1_86"
                     /locus_tag="ctg1_86"
                     /protein_end="190"
                     /protein_start="4"
                     /score="89.7"
                     /tool="antismash"
                     /translation="AFYDVDDTLINIKSMFDFFQFWASENGLISQQEQFDSQFSVLARK
                     MSSREELNRAYYRFFKGVPLLKIEQCAERWFKNSFSNTEIFISYTLKSILAHRVLGHNI
                     VLVSGSMTPLLKPIAQLLGITDILCTKLATDQSGVVTGEILETQTIGEGKAIVIRQYAL
                     ENDINLSACFAYGDDVSDIPMLA"
     PFAM_domain     complement(3356..3910)
                     /aSDomain="HAD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12710.9"
                     /description="haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_86_0051"
                     /evalue="7.30E-29"
                     /label="ctg1_86"
                     /locus_tag="ctg1_86"
                     /protein_end="189"
                     /protein_start="4"
                     /score="101.7"
                     /tool="antismash"
                     /translation="AFYDVDDTLINIKSMFDFFQFWASENGLISQQEQFDSQFSVLARK
                     MSSREELNRAYYRFFKGVPLLKIEQCAERWFKNSFSNTEIFISYTLKSILAHRVLGHNI
                     VLVSGSMTPLLKPIAQLLGITDILCTKLATDQSGVVTGEILETQTIGEGKAIVIRQYAL
                     ENDINLSACFAYGDDVSDIPML"
     CDS             complement(3925..4155)
                     /locus_tag="ctg1_87"
                     /transl_table=11
                     /translation="MPIIKITAWPFANEKSASLLIADVTRVIHNQLGCPLDKITVYIEE
                     ISPSRWGDGGIAGDNPDFKVKSRRMCYEDGE"
     PFAM_domain     complement(3991..4101)
                     /aSDomain="Tautomerase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01361.23"
                     /description="Tautomerase enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_87_0052"
                     /evalue="1.80E-04"
                     /label="ctg1_87"
                     /locus_tag="ctg1_87"
                     /protein_end="55"
                     /protein_start="18"
                     /score="21.4"
                     /tool="antismash"
                     /translation="LLIADVTRVIHNQLGCPLDKITVYIEEISPSRWGDGG"
     CDS             complement(4161..4997)
                     /locus_tag="ctg1_88"
                     /transl_table=11
                     /translation="MEINKTYIYELSITTQGPLYPPSEVIDKNGDFVVIGTLPQEGERN
                     WGMAIVDKKTPVPTFGYVEPYLIKKDLSNASIKELSDIELFTLPLPLPSNNYPMVFAPE
                     QCPNAGEVVRDSCSLNQAYISDYRESDGRRKINKITLADWVKAEGTLTVTVADNSRSAR
                     FDFVFSHLIPNSLYTVMSLRENDLNPAMLSRPGPLGIPNVFVTDEHGSASYWAILDNPF
                     PSNVDEDANRIINVVVLFMSSQQSYGGAIGLYGLGGDIHAHLKLKKSDFHDITTLG"
     CDS             complement(5001..5780)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_89"
                     /sec_met_domain="AfsA (E-value: 2.7e-10, bitscore: 38.4,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKNQNTDLLVVGDKFHEFAMSNDIVTLSQLDLMTKIPSKVLARN
                     NSVVIGQGVRKDTIGNILENYHHYNQQVSNIDLHTLLQEQYPQGSNSYTHKKEEHNILI
                     GKAKKIDKDIYTLPLIIDERCELMGDHQSGKHLQGMLLVEAFRQTFIAITEEFYPFLGD
                     IEKYFVINSLNTSFHNFIFPIAANIIYKVNDIDVNERREKISSRIEAWQNDVLCASMEA
                     NFTVYPLDIISKKEAELAEQAIVNHFIKINSNKMIPE"
     PFAM_domain     complement(5106..5498)
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_89_0053"
                     /evalue="2.10E-17"
                     /label="ctg1_89"
                     /locus_tag="ctg1_89"
                     /protein_end="225"
                     /protein_start="94"
                     /score="63.4"
                     /tool="antismash"
                     /translation="HKKEEHNILIGKAKKIDKDIYTLPLIIDERCELMGDHQSGKHLQG
                     MLLVEAFRQTFIAITEEFYPFLGDIEKYFVINSLNTSFHNFIFPIAANIIYKVNDIDVN
                     ERREKISSRIEAWQNDVLCASMEANFT"
     CDS             complement(5811..6416)
                     /locus_tag="ctg1_90"
                     /transl_table=11
                     /translation="MSANYLMISRYPLKKGMEPRLAELLQPSAMKNYYLSIQGENKELL
                     EFNSYAGFNEIQHDENNLDNILDNLTELLSGDVKRELVKYVESPIASEKCFPDSEYVQL
                     RHVEVVPEFHSQYRSWREETIFNVVRSNKDKIESFEAYHSVFSTQPGVMFVSAFSVAPE
                     EYMKSFTDENYQKIIQQAGDKYITGGNDGLYTRIYQKI"
     CDS             6599..7513
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 119.1; E-value: 3.6e-36)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_91"
                     /transl_table=11
                     /translation="MRIFSKRLPTIRQLQFFIAVCDDMSFRRAAERLGVSQPPLSTQIR
                     NLEENLGTTLFLRDTHQVSLTEAGKLFELQSRKLLNTMVDNLAEIKKHSISDQGFRAGT
                     TKTLDFNLMPKIQHMLDELSNANTIYKDTYTSKQLLMEMLNGHLDFSIVAEKPYQNELL
                     EFKFIYKEINLITLPSSHPASKKEFVDLKDVSDLPLYWFNRLANIDYFDKCEGIFDTLP
                     FKLTRKPEPSDPLRMLSEISLGRGMAFIPYSMCMVSRSGITYKRMTPYYEDKFKINIYL
                     SWRKDLKKISALNAIQKILSLEP"
     PFAM_domain     6629..6808
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_91_0054"
                     /evalue="1.50E-21"
                     /label="ctg1_91"
                     /locus_tag="ctg1_91"
                     /protein_end="70"
                     /protein_start="10"
                     /score="76.2"
                     /tool="antismash"
                     /translation="IRQLQFFIAVCDDMSFRRAAERLGVSQPPLSTQIRNLEENLGTTL
                     FLRDTHQVSLTEAGK"
     PFAM_domain     6917..7474
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_91_0055"
                     /evalue="3.20E-08"
                     /label="ctg1_91"
                     /locus_tag="ctg1_91"
                     /protein_end="292"
                     /protein_start="106"
                     /score="33.3"
                     /tool="antismash"
                     /translation="TLDFNLMPKIQHMLDELSNANTIYKDTYTSKQLLMEMLNGHLDFS
                     IVAEKPYQNELLEFKFIYKEINLITLPSSHPASKKEFVDLKDVSDLPLYWFNRLANIDY
                     FDKCEGIFDTLPFKLTRKPEPSDPLRMLSEISLGRGMAFIPYSMCMVSRSGITYKRMTP
                     YYEDKFKINIYLSWRKDLKKISA"
ORIGIN
        1 aatccaagga ttaattacat ttaaattaat atgcttagcc gccaaatact ttgagcatgc
       61 cttggtaaaa cctgctaaag cagcattgac cgtactatta ataatgaaaa gtggatctgg
      121 gtcatagcag aaagtaccgt taataataat gactttccca ccattatact ttgacatcat
      181 tctagatacc gcttgggtca tgcgtattgt gcccatcaac ttcgcctgca tcgtggcctg
      241 ccaatcttct tctgtggtag agaagaaatc ggtaggctca ccgtttcctg ctgcatttat
      301 cagcacatct atcgggccat aatatttatc aatataggct accccctgct ccacagaact
      361 ttggcttgaa atgtctattt tatgcgtaac aatgctatcc tgattattgc tctcaccaat
      421 taactccttt tttatttgcg ccaatttact gtcactgcgc cctactaata tgactttata
      481 gtttttttca actaaacatc tggctatttc tttaccaatt gaacctgttg caccagttac
      541 taccgctgat ttatttaaca tgattttatt ttgaacctct aatagggtta atagcactac
      601 tggctgtata cttaccgata taattaatag ccagaacaat attaatcact gatactgaaa
      661 cacaaattaa caccacacca agccagtgca ttgaactcca aacaaggcca agaatgtatg
      721 taccaaaact cccaccagcc aaacatgaca agagatataa tgatgaaatc gtccctttag
      781 atgaaatgtc tacaagttgg ttaataatag acataataat aggctgtata ccaaaaacaa
      841 atatgaaaaa agaaaaaata ccaaatgcaa caatataaat gttactacca aaagcaatca
      901 ctaatataga tacagacact ccacataaaa atgtgattag aatctttctc ttatcaatgc
      961 tcattgcaag cctcgcacta ataaatgccc caccaaccgc acttatgcca acaaagttca
     1021 accaccctaa tgccgttgac gataaattaa atggtgcgcc cttaagataa tacgttagaa
     1081 aagaagacaa ccctaaatag ctgaaaaaga gaaggaaacc caaagataaa aacaaaacga
     1141 tctttctgtc catgagtatt tttatcgcat taatataaac atcactcaat tttttatgat
     1201 tatgcctaac agtcacattt tcttttagcc caatgataat aagcagcatg gaaacaatga
     1261 ctaatgccgc atacatagag aatgccatac gccaagaaaa gtgatcagaa agaataccaa
     1321 taatactgcg actaaaaata atgccaacaa ttgatgctga gatcattaac cccattgcac
     1381 gcggaagctt atatgcttct gtatttttag ctgtataaga aaataaagca gcaggaacag
     1441 cagcggcaaa gaagccaagt aatgccatag caagcaggaa tatattatat ctcgtaatgt
     1501 aaagacagat gaacagacag ataataacac ctgcacaccc aaacaagctc aaggatttag
     1561 ctgaaaccct gtcggataaa gggccaaata taaaaaaaga aatagcgtat ataaaacacg
     1621 acacactaaa tgagtagcgg gcgtctaata catccacgtg aaaacttgct gatatctctt
     1681 ggaagatcaa ttgtgtaata taaacagaac cgaccgacaa aacaacacca ataaccgaga
     1741 tcatcagact tgataactca ctatctaaca tagtgttttt cagtatgtta tttgcatgca
     1801 taattgcacc tatttccatt cataataatt ttactcctcg cgttatttca cctgagataa
     1861 atattatcaa tgatgccaat tttacatcgg catcataata gggcagtaac taattacaat
     1921 atctaaacta aggctccgca attcacttga gcgcaaattg ctaatataaa ctcaaggcag
     1981 aaagacatta atcatgccgc tatacccgtg ccaccgccat tgcaagaccc tcaccgcctc
     2041 caacacacaa tgctgcgatt ccatttttga ggttccgagc actcagttga tgaataagtg
     2101 aaaccaaaat acggcagcct gaagctccaa tagggtgccc taaggcaatt gcaccaccat
     2161 taatgttaat tttctctttc gggatcgcta acgttctttt aatggctaat gcctgtgcag
     2221 caaaagcttc attgcactca aaaagatcta tctgcgaaat ctctttattg atcttctcca
     2281 agcactgagt aattgccgaa atcggagcaa cacccattat tgaggggcaa atgccggtat
     2341 tggcaaaagc agaaatttta accagcggcg tcaaccccag ctctttagct ttacttgcgc
     2401 tacaaacaat gactgctgcc gccccatcat tcaatgacga agcattgcca gccgttaccg
     2461 taccctgaga atgaaacgca ggctttaact tcgccagcct ggcagcctca gtgactcttg
     2521 gcccttcatc agtatcaata acctgcgagc cttttttatg gatgacggta accggtgaga
     2581 tctccgcttt aaatttccct tcttctatcg ctgctaacgc tttttgatgg gagcgtattg
     2641 agtacgcatc ttgctcctca cgtgaaatac tatattggtc agcaacattc tccgcagtga
     2701 tccccatatg gtaaccatta taggcatccg ttagcccatc attaaccatc gaatcaacaa
     2761 tgttactatt cccgacacgc acaccctgac gtgaagacaa gaggatatga ggggatagag
     2821 acatattctc ttgcccaccg gcaataatca cttcagcatc gccatgacga atagcctgaa
     2881 tagctaactg gattgcgatc atcccagaac cacaaacttt attgatcgtt agcgcacaga
     2941 cattatttgg caacccagca tttaatgcgg cctgacgtgc aggattttga ccacaccccg
     3001 ccgttaacac ctgccccata ataacctggt caacattttc aggcttaaga ttatatgtct
     3061 gtaataaatc ttttataaca gccgtgccta attcggtagc agggacagtg gataaccccc
     3121 cctgaaatga accgatggcc gttctcttgg cacctacaat aacaatatct tccatacaga
     3181 atccctcata aaaaattctt aatcagcaat gattatcaga aatagaatat tgcatttata
     3241 acaatgtgtt tattagtctt actcactcaa cacgcacaat cggccagtta ttatttgatg
     3301 catagtggct aagtgccgtt ccttcaccaa tacatatcgg atggccaaca caagcaagca
     3361 taggaatatc agaaacgtca tcgccatagg caaaacaagc cgataaatta atgtcgtttt
     3421 ctaaagcata ttgcctgata acgattgctt taccttcacc aattgtttgt gtctctaaaa
     3481 tttcgccggt aacgactcct gactgatcgg tcgctaattt tgtacagaga atatctgtaa
     3541 tgcctaatag ctgggcaata ggtttcaaga gtggtgtcat tgaaccagag acaagaacaa
     3601 tattatgacc caaaactcta tgggctaaaa tgctttttaa tgtataactt ataaatatct
     3661 cagtattgga aaatgaattt ttaaaccagc gctctgcgca ctgttctatt tttaataaag
     3721 gaactccctt aaaaaaacga taataagctc gatttaactc ctccctgcta ctcatcttcc
     3781 tggccaaaac agagaactga gagtcaaact gttcttgctg gctaatgagg ccattttcac
     3841 ttgcccaaaa ctgaaagaaa tcaaacatgc tcttaatatt tatcagcgta tcatccacat
     3901 catagaatgc agtttggcgc atctttattc cccatcctca taacacattc ggcggctttt
     3961 caccttgaag tcaggattgt caccagcaat accgccatcc ccccatcgag aaggggaaat
     4021 ctcttcaata taaacagtga tcttatctaa tgggcaacct aactgattat gtatgactcg
     4081 tgtgacgtcg gcgataagta agctcgcaga tttctcattc gcaaatggcc aagctgttat
     4141 tttaataatt ggcataatat ttatcctagt gttgtaatgt cgtggaagtc tgattttttt
     4201 aatttcaggt gagcatgtat atcaccacct aatccatata atcctattgc tccaccatag
     4261 ctttgctgtg aactcataaa aagcacaact acattgataa tacgattcgc atcttcatcc
     4321 acgttcgatg ggaacggatt atctaaaata gcccaataag atgcactgcc atgttcatca
     4381 gtgacaaata catttggaat acccagaggc ccaggtctgc ttaacatcgc aggatttaaa
     4441 tcattttctc tgaggctcat aactgtatat aaactgttag gaataaggtg actaaaaacg
     4501 aaatcaaatc gtgctgaacg actattatcc gctacagtca cagtcaaggt tccttctgct
     4561 tttacccaat ctgccaaggt gattttattt attttcctgc gcccgtcact ttcacgatag
     4621 tcagaaatat atgcctgatt aagggaacag ctatctcgta ctacttcgcc agcgttagga
     4681 cactgctcag gtgcaaatac cattggataa ttatttgaag gcaatggtaa tggcaatgta
     4741 aaaagctcta tatcacttaa ctcttttatc gatgcattag ataaatcctt cttaatcaaa
     4801 taaggctcaa cataaccaaa cgtgggaaca ggcgtttttt tatcaacaat cgccattccc
     4861 caatttcttt ccccttcttg cggcaaagta ccaataacaa caaaatctcc atttttatcg
     4921 atcacctcac tgggtggata caatggtccc tgtgtggtaa ttgataattc gtaaatataa
     4981 gttttattaa tctccatttt ttactctggg atcatcttgt ttgaatttat tttaataaaa
     5041 tgattaacaa tggcttgctc tgcaagttcc gcttctttct tactgattat atccagtgga
     5101 tatacggtaa agtttgcttc catagaggca cataaaacat cattctgcca tgcctctatt
     5161 ctggagctta ttttctcacg ccgctcatta acatcgatat catttacctt atagataata
     5221 ttcgcggcga ttgggaaaat aaaattatga aaactagtat tgagtgagtt gataacaaag
     5281 tatttttcaa tgtcaccaag gaatggataa aactcctcag tgatagcgat aaatgtttgt
     5341 ctaaacgcct caactaatag catcccctgc aagtgtttgc ctgattgatg gtcgcccatc
     5401 agttcacagc gctcatcaat aatgagtggc agagtataaa tgtctttatc aatttttttg
     5461 gctttaccaa taagaatatt atgttcttct tttttatgag tatagctatt actaccctgc
     5521 gggtactgct cttgtaataa cgtatgtaag tcgatattac tgacctgttg gttatagtga
     5581 tgatagtttt ctaatatgtt acctatggta tcttttctca ccccttgccc aataactaca
     5641 gaattatttc tagctaatac tttagacggg atttttgtca tcaagtctaa ctgacttaat
     5701 gtcacaatat cattgctcat ggcgaattca tgaaacttat cgccaaccac caagaggtcg
     5761 gtgttttggt tttttagcat aactattttt ctctcttttc gttaataaaa ttaaattttt
     5821 tgatagattc tagtatataa accgtcatta ccaccggtga tatacttatc acccgcttgc
     5881 tgaatgattt tttggtaatt ctcatcagtg aatgatttca tatattcttc aggtgctact
     5941 gaaaaagcag aaacaaacat aacaccaggt tgagtactaa aaactgagtg ataggcttca
     6001 aaagattcaa ttttatcttt gttactgcgg acaacgttaa aaattgtctc ttcccgccag
     6061 ctacgatatt gagaatgaaa ctctggaaca acttcaacat gccgtagctg gacatattca
     6121 gaatcaggga agcatttttc tgatgcaata ggactttcaa catacttaac caactcacgt
     6181 tttacatcgc cagacagcaa ctcggtaagg ttatcaagaa tattgtcaag attattctca
     6241 tcatgctgga tttcattaaa cccagcgtaa ctattgaatt ccaacaattc tttattttca
     6301 ccttgaatag aaaggtaata gtttttcatt gcagaaggtt gtagcaattc ggccagtctt
     6361 ggctccattc ctttctttaa tggataacga gaaatcatta gatagttagc agacatagta
     6421 tacttccttt ttagtcaatt atgggttaag cgttattttc ttggaaacat cttacatttt
     6481 taaaacggtg tttcgaaata tttattttgt gataggataa agatatcagc aggtataaag
     6541 ccctagaaaa ccttactgct ctatcgctta aacatgaaca tatatgttgg agaaagtgat
     6601 gcgaatattt agcaaaagac tccctactat cagacagtta cagttcttta ttgcggtatg
     6661 tgatgatatg agcttcaggc gggcagccga gcgtttaggc gtttcacaac caccactgtc
     6721 aactcaaatt cgtaatcttg aagaaaatct gggtacaact cttttcctcc gcgatacaca
     6781 tcaggtatct ctcacagaag ctggaaaact gtttgaattg caaagtagaa aactattgaa
     6841 caccatggtt gataatttgg cagaaataaa aaagcacagt atttctgatc aaggatttcg
     6901 tgctggaacg actaaaacgc tagattttaa tctaatgcct aaaattcaac acatgcttga
     6961 tgagttatct aatgcgaata caatctataa agacacctac acttctaaac aacttttgat
     7021 ggaaatgctt aatgggcatt tagatttttc tattgttgca gaaaaacctt atcaaaatga
     7081 gctattagag tttaaattta tctataaaga gataaacctg ataactcttc caagcagcca
     7141 tcctgctagc aaaaaagagt ttgttgactt aaaagatgtc agtgacctgc cattatattg
     7201 gtttaaccgc ctagctaaca ttgattattt tgataaatgt gagggaattt tcgacacatt
     7261 accctttaag ctgaccagaa aaccagaacc gagtgatcca ttacggatgc tgtcagaaat
     7321 atcattaggc cgcgggatgg cttttattcc ttattcgatg tgtatggtta gtagatcggg
     7381 tattacttat aaacgcatga ctccttatta cgaagataag ttcaaaatta atatttatct
     7441 ctcttggcga aaagatttaa aaaaaattag tgcgctaaat gcaatacaaa aaattctatc
     7501 cttagagcct tagataaaca gtaatataaa cggacagata gcatactgtc cgtgacgctc
     7561 actgaatcaa ctcacagcgc ttacctcaac cagcagcacc cttgtaaagt ggcaggatct
     7621 aatggatgat tctcccgata gcgcatcaga aattcagaaa tgcctgagtt aattagcaga
     7681 atggatgata ttatcgcgaa aaattacccg caggcaccga cctgcacgct ggtagacatt
     7741 acgagtcaag cagtaatatg tctggctgct ctctcagcat cggggaatat tttaactcat
     7801 attttcaaca aaaaaaattt gaggctcttt ataggatttt atttaaaata attaaaaata
     7861 aaatcattcc aaatcaatat cattactacc ctaataatat tcccacatag aagaaaacac
     7921 caagtcaata cagctctgtc caattcaacc aaccttcact tttagcttta ttttataatt
     7981 ggctatactg tttcattgcc aacacagttc aactaacgct atcctctatc aacaacatat
     8041 ggtggataat tttaaccgcg agggctttgc gatagagctc ggcctgaata tcccaacaca
     8101 gtaagtggtt aaagtgctgg agcgtttaga taaaacataa tgttatttta ttattgacaa
     8161 ttaagggaga ttgcctagga atacctaaat ccatggccta ttttatttgc ccacaacatg
     8221 gaatacgaaa tacctcaacc tcaaaacggg gctcactact gcctgtttgc aataatgtcg
     8281 taccctttgt atcggataaa taaccacaga caaggaaaga taatatgacc attagaatta
     8341 ccaaaatagc cagcctcatg atagcgacgc tggcaactgg ccctttatct gctgaagcga
     8401 gaactcccct tattttcaat acaacaaccc cccagaacga cctaacgggt gccatggctg
     8461 cacaggtgca gtttgcccag agccagatcc tgcccgccca gccaaaggag ggtgatcgcc
     8521 agccgaccct gactagtttg cgtaaaagcc tgctgttggt gcggccattg caggctgatg
     8581 aggtaacacc agtacgggta caggcccaag atgccaatgg caaagttctc ggcaccctga
     8641 cactagcacc gccatcagcg ttgccagaga ccgtctatca cttgtctgat gcacctaaag
     8701 aagatgtgga ttttaccccc acaaacggat cgtccgtaac catcagcagc agtgccgatc
     8761 tggataagct cagcgataaa agtgccagct ttcttaagga gcgcttgacg ggcaaggcgc
     8821 tggtagatat ccagactgcc gacggctact gggtacagga tatctatcta cccgcaggcg
     8881 ctgagtggca agacaaaatg gtacgggtgc gctcaaatgc gggctacagc tcgaatatct
     8941 actacggcaa taagcaggtg actgtttcac gggggcagac tcttcagttc aaatctgtca
     9001 atggccagtg gttctaccag gaagaacttg agaacaaccg catcacctat gcgcagaata
     9061 cctggagtgg cgagctgcct gctgaatgga tcctgccggg gttgagcctc accattagcc
     9121 aagggaaaca cagcggcgaa cttaccagga tcagggttgg agcacccaat gaattgctgc
     9181 tccacaccat cgacatcggc atgttgactc ccccacggga tcgtttcgat tttgccaaag
     9241 acccagaagc gcatcgcgaa tacttccaga ctatcccggt cagccggatg atcgtcagcc
     9301 agtacgcacc cgttcatcta caggaagtga tgctgccgga tggcactctg ctcactgatt
     9361 tcgacccgag caccgggggc tggcataccg gcaccatgcg cgagcagatc ggcaaggagc
     9421 tcatatccca cggcatcgac aatgccaact acggcatcaa caacacggcg acacaaggga
     9481 acaagagcta ttctttcgat gccgcccaac tggtggccca caacagccgc ggtaactacg
     9541 ccaatggggt acaggttcat ggcggctccg ggggagctgg catcgtgacc ctggataagt
     9601 cgctcggcaa tgaattcagc catgaagtag gccacaatta cgggcttggc cactatgtcg
     9661 atggcttccg tggctcagtc caccgcagcg ccgatcagat taactccagc tggggctggg
     9721 atagcgacaa gcgccgtttc attcccaact tcttcccgac ccgcaccaat gcagacgcct
     9781 gtctggatgg agaatgtcag cccccgtttg aggggcgcaa gtttggtttc gactcaatgg
     9841 caggcggctc tccattctct aacgccaatc gcttcactct ctacacgccc aattcggcag
     9901 ccattatcca aagtttttta gaaagcaaag cggtgttcga tgctaactca cccaccggct
     9961 ttagcaaatg ggacgcagca accgcccgta tggaacccta tgagcacaag gttgagaagc
    10021 tagagcagat tgatgccccg gttgatgatt tgagcgaaaa ccggctaatg acgctatttg
    10081 atgaatattc ggtggtcaat atcgctatgt gggatggcca ctggacacgt tatatccgtg
    10141 tacccgctgc ttctgacaaa aaccagaacc gcagtctgac catcaatcac aaggcgagct
    10201 acaacagcat tctcactatc aacggtgaag atatccttat ccaaaagggc gtcaaaaaga
    10261 gctttacctc tgatggccaa aggtggcaag agagcgctga gatcgatacc cgagttgttc
    10321 gcaaaccaga gcagtttggc gttccggtga caacactagt gggttactat gacccgcaag
    10381 gcaccttacc cagctatatt tacccggcct tacatggcgc gtatggattc acctattccg
    10441 atgacagcac cgaaattgca gacggtgact gccagttgca ggtggaaact gacaacggga
    10501 ttctgcactt caaactgacc aaccatcgcg ccatcagcac actgatgaac aaattccaca
    10561 tcaacgtccc tacggcgagc caacctagta gagctaccgt gctatgccac aaccaaagtt
    10621 ttactgaaag aacactatca agcgcaccag aaggtctctc atataccgtt aatggccgag
    10681 ctctaccggc aaaacataat gaaggttgca ttatatctaa tcaaacaggc gataaatatt
    10741 gccttcctat cggcgaacgc tctggatact ccttgccttc
//
