LOCUS       NZ_LT604075.1          10419 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LT604075.1 Ligilactobacillus salivarius isolate LPM01 plasmid II.
ACCESSION   NZ_LT604075
VERSION     NZ_LT604075.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:14:17
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 96552
            Orig. end    :: 106971
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10419
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[101552:101971]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5419
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10419
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10419
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(513..1265)
                     /locus_tag="ctg2_92"
                     /transl_table=11
                     /translation="MSDMEEKFLNYDIPNFVKESPNHLKLFEKERIILKNNHDKWGIYF
                     SEELGHPLEYKENSGKVDYIYDSFLEAYSQADNDGEVWFSDEIAHEVFGEPEDEDLNEK
                     GEFGSLSDDFFWAKHQLIFRHHGDYNVKNLENEYQEWKNLDKKVKEDSFTHENFLLIYE
                     WLRTHPNFWKENVHGDRVFWETAHMNLNFMDIYPTSSETSGKVEWWAEGGYHVLDDTDV
                     PYATTYYHDIALVTNGRKPLTLVRGYKP"
     CDS             complement(1367..1501)
                     /locus_tag="ctg2_93"
                     /transl_table=11
                     /translation="MKKSILVFIVLLLLVIDIFKCGRVAGIIPLFLILVAAKVKRSKK"
     CDS             complement(1601..1798)
                     /locus_tag="ctg2_94"
                     /transl_table=11
                     /translation="MKINKKFYKNYTFYIGLVMLSIAVGSIFFDKGYFLFTIIDIFFAY
                     LGIKYVYQSLVVTKRCKRSR"
     CDS             complement(2091..2321)
                     /locus_tag="ctg2_95"
                     /transl_table=11
                     /translation="MVEIGIIILLVVGFVVISMLKVNFTRNSKYAGFLLLILLNLNGLM
                     RTPMLTMRGLILLGTLMIFIVMLIKEIRKYS"
     CDS             complement(2358..3152)
                     /locus_tag="ctg2_96"
                     /transl_table=11
                     /translation="LEEYGIIICDDEKDQVRRIHDLVKYAIWSLEDSADSKDKEFKITL
                     EANSYIEIADYLEDNKVDSGVYFLDIELSRDRADKDGIDLAEFIRQKDPNAQIIFITAY
                     ENLAAMTYRRRTGALDFITKNDSDEVIQKRLNETLSLAARRIRESHAIKKMTFSYKMGR
                     RIINENINDILYIITTPKSHRLKIITVNGMGEFTGDIKKLEAENDFLEKISQSCLANPS
                     NIVEINLSTRVISFKDGYKETFPRRSKAKMKSLIERYNLKTV"
     PFAM_domain     complement(2385..2663)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_96_0002"
                     /evalue="1.60E-13"
                     /label="ctg2_96"
                     /locus_tag="ctg2_96"
                     /protein_end="256"
                     /protein_start="163"
                     /score="50.8"
                     /tool="antismash"
                     /translation="RIINENINDILYIITTPKSHRLKIITVNGMGEFTGDIKKLEAEND
                     FLEKISQSCLANPSNIVEINLSTRVISFKDGYKETFPRRSKAKMKSLI"
     PFAM_domain     complement(2751..3137)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_96_0001"
                     /evalue="5.70E-11"
                     /label="ctg2_96"
                     /locus_tag="ctg2_96"
                     /protein_end="134"
                     /protein_start="5"
                     /score="42.7"
                     /tool="antismash"
                     /translation="IIICDDEKDQVRRIHDLVKYAIWSLEDSADSKDKEFKITLEANSY
                     IEIADYLEDNKVDSGVYFLDIELSRDRADKDGIDLAEFIRQKDPNAQIIFITAYENLAA
                     MTYRRRTGALDFITKNDSDEVIQKR"
     CDS             complement(3166..4455)
                     /locus_tag="ctg2_97"
                     /transl_table=11
                     /translation="MVNLNSTSGYIVATLILFINTFCRYSFFYLLTPTRKSKKYNLLFI
                     LLTFPVILLINGVGDIIGFFAPFIEIFIFYIVYRQLTLDYRLCGRLLMLDLFSYITFGA
                     SALFFTLFTNYYTMVSVIILDVSLNIFEYIILTKTTIIEKLDDEYGLLYFYLILYIWIS
                     SMVIYYLTTYVFNIDAVSYIIAMVVVVSQLFFSLFVYSINKKIRQDKLSLQQINDLKIY
                     TQQLESSQRGLRKFKHDYQNMLLSLKLSAKKSHDKELIDKLAEYSSKTLEDKVLWQFND
                     VDNVKDELLKSLFISKLNRIFQNNIQYSFECRIVIENLSNKYNSFDIVRILGIVYDNAI
                     EESLEFGDEAKIDTMIYQENGELEIEIRNRYRDTDLTIQDMRKSGFTTKKNHDGLGLAN
                     IEELSQPYNDIFINYQIKDGWFTFLMVMSI"
     PFAM_domain     complement(3178..3483)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_97_0003"
                     /evalue="2.10E-15"
                     /label="ctg2_97"
                     /locus_tag="ctg2_97"
                     /protein_end="426"
                     /protein_start="324"
                     /score="56.5"
                     /tool="antismash"
                     /translation="SFDIVRILGIVYDNAIEESLEFGDEAKIDTMIYQENGELEIEIRN
                     RYRDTDLTIQDMRKSGFTTKKNHDGLGLANIEELSQPYNDIFINYQIKDGWFTFLMV"
     CDS             complement(4691..4858)
                     /locus_tag="ctg2_98"
                     /transl_table=11
                     /translation="MVFWVTVIVAYSIFISIYTSLKEDGHYKLFDEKVIEKNKKISYVR
                     AWVLNFMWWL"
     CDS             complement(5001..5207)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_99"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 7.5e-11,
                     bitscore: 36.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLDKRFTIMTEDNLASVNGGKNGYGGSGNRWVHCGAGIVGGAL
                     IGAIGGPWSAVAGGISGGFTSCR"
     PFAM_domain     complement(5016..5189)
                     /aSDomain="Bacteriocin_IIc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10439.11"
                     /description="Bacteriocin class II with double-glycine
                     leader peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_99_0004"
                     /evalue="4.80E-14"
                     /label="ctg2_99"
                     /locus_tag="ctg2_99"
                     /protein_end="64"
                     /protein_start="6"
                     /score="52.2"
                     /tool="antismash"
                     /translation="RFTIMTEDNLASVNGGKNGYGGSGNRWVHCGAGIVGGALIGAIGG
                     PWSAVAGGISGGF"
     CDS             complement(5225..5419)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_100"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.5e-16,
                     bitscore: 53.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKEFTVLTECELAKVDGGKRGPNCVGNFLGGLFAGAAAGVPLGP
                     AGIVGGANLGMVGGALTCL"
     PFAM_domain     complement(5240..5416)
                     /aSDomain="Bacteriocin_IIc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10439.11"
                     /description="Bacteriocin class II with double-glycine
                     leader peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_100_0005"
                     /evalue="3.10E-15"
                     /label="ctg2_100"
                     /locus_tag="ctg2_100"
                     /protein_end="60"
                     /protein_start="1"
                     /score="56.0"
                     /tool="antismash"
                     /translation="MKEFTVLTECELAKVDGGKRGPNCVGNFLGGLFAGAAAGVPLGPA
                     GIVGGANLGMVGGA"
     aSDomain        complement(5363..5407)
                     /aSDomain="TIGR01847"
                     /aSTool="tigrfam"
                     /description="bacteriocin_sig: bacteriocin-type signal
                     sequence"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_100_0001"
                     /evalue="5.30E-03"
                     /identifier="TIGR01847"
                     /label="ctg2_100"
                     /locus_tag="ctg2_100"
                     /protein_end="19"
                     /protein_start="4"
                     /score="15.3"
                     /tool="antismash"
                     /translation="FTVLTECELAKVDGG"
     CDS             complement(5425..5682)
                     /locus_tag="ctg2_101"
                     /transl_table=11
                     /translation="MLKKLWETWLDGGFIRGKKRYVIAPVIWALLIPLGIWLFGNEDMS
                     YLDYIQTPKMIIVAIFCLIGGSTLLYLLDTTMKVNKHMKG"
     PFAM_domain     complement(5533..5682)
                     /aSDomain="DUF5976"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19401.1"
                     /description="Family of unknown function (DUF5976)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_101_0006"
                     /evalue="7.70E-32"
                     /label="ctg2_101"
                     /locus_tag="ctg2_101"
                     /protein_end="50"
                     /protein_start="0"
                     /score="109.0"
                     /tool="antismash"
                     /translation="MLKKLWETWLDGGFIRGKKRYVIAPVIWALLIPLGIWLFGNEDMS
                     YLDYI"
     CDS             complement(6354..6527)
                     /locus_tag="ctg2_102"
                     /transl_table=11
                     /translation="MNNNFIQVDKKELAHIIGGRNSYDYIDSGQFGYDIGCTIANTKFF
                     KRLRHSNQNICS"
     aSDomain        complement(6471..6515)
                     /aSDomain="TIGR01847"
                     /aSTool="tigrfam"
                     /description="bacteriocin_sig: bacteriocin-type signal
                     sequence"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_102_0002"
                     /evalue="9.60E-04"
                     /identifier="TIGR01847"
                     /label="ctg2_102"
                     /locus_tag="ctg2_102"
                     /protein_end="19"
                     /protein_start="4"
                     /score="17.6"
                     /tool="antismash"
                     /translation="FIQVDKKELAHIIGG"
     CDS             6759..7022
                     /locus_tag="ctg2_103"
                     /transl_table=11
                     /translation="MNSFSNNINFSKISVSLITLLLLIWTLVDGNLIHLGILAFSSLVT
                     TMLHFHYFESTDDKHPLNRIDFVLQLLFIFISIIKFFLISGR"
     CDS             7309..8277
                     /locus_tag="ctg2_104"
                     /transl_table=11
                     /translation="MRYIKFTLLIYSFLLTWGITTNSISADEVTPTTTSETTVTSQSQS
                     IPVDSNDEDAAIEEKFYSHDVTVDEYNQNVANFNKVDTNTVKNMVTENTNNLDQVLYIG
                     RPTCYFCRQASPHLRDFNQLINNQLYYYDIDAEPNAHDFAFKEIGIPGTPTTMRLKNGK
                     LVSAWVGGEKTGQEFYDFLFFADANKLADSYTIKKTVSANTSNTVITNNQNVKPTIKPI
                     PTNINQLKEEKTTPELVNTTSQSSKPVKKVQKQTTNKENKNSVLPQLGAVPPYHQPLFK
                     LPIPRLIPKRLEHIIALVSFLVLYIGITIWTGLSLKNWDKK"
     CDS             complement(8460..8801)
                     /locus_tag="ctg2_105"
                     /transl_table=11
                     /translation="MKAIYRGRKVDVWQVSRDNIQPDWVKYAFEHNGLRWLHGSGNKVR
                     IYWPAVTRAKKGIIRTILNGISASLVSINGGSASMYDIGFEGDVIDFTNSKVVTAEKFA
                     KKYRVVSEE"
     CDS             complement(8822..9091)
                     /locus_tag="ctg2_106"
                     /transl_table=11
                     /translation="MMDYLVIKAIIWIFFILSAILEVNYKKKYGELDKRARKQATLGIF
                     LIVTTIFDEGYENKILYTIVLIALLVYIVLVMYRLVMAIKDRKK"
ORIGIN
        1 ggattccgaa tactcgtcta tttttaacgg attccagtat aggaactatt cttatattag
       61 ttttatctat ttttatatgt gttttttctg taatttataa taaaacactc tcgttctctt
      121 tggtatatat tttcttttgt attaggatta agtcctatac tatttttaat tttcgttggc
      181 atttttttag cattaggaat gccttttgca ccatgattaa ctttcaagta gaaaccggaa
      241 aaatttaaaa aatcgccaaa gatttgcact aatccttggc gatttttact tggcgtaagc
      301 tattaaattt ctattttaaa tattcagtca gattcgcatc cagaatcctt agcccatctt
      361 tcaaagattg catcacgtct tgcttcttta tccttcaaca ttccatgtgt ttgtaaccaa
      421 acgtttttcg caaaattcag tactgcttgc tcatatgtat taccaccaca gtataaaaga
      481 aagactcaaa atagctccaa aaggagctat tactagggct tatatcccct cactaaagta
      541 aggggtttac gcccatttgt cactaaagca atatcatgat aataagttgt tgcatatggg
      601 acatcagtat catctaaaac atgatatcca ccttcagccc accactctac ttttccactt
      661 gtttcactag aagttggata aatatccata aagtttaaat tcatgtgtgc tgtctcccag
      721 aagaccctat ccccatgaac attttccttc cagaaattag gatgtgtcct aagccattca
      781 taaattaata gaaaattttc atgcgtaaag ctgtcttctt tgactttctt atccaaattt
      841 ttccattctt gatactcatt ttctagattc ttaacattat aatcaccatg gtgtctgaaa
      901 attagttgat gctttgccca aaagaaatca tcgctcaaac tcccaaattc tcctttttca
      961 ttaagatctt catcttcagg ttcaccaaat acttcatgtg ctatttcatc tgaaaaccaa
     1021 acttctccgt cattatcagc ttgagagtag gcttccaaga aagaatcata tatataatct
     1081 acttttcctg aattttcctt atattccaat ggatgcccta attcctcact aaagtagatc
     1141 ccccatttat catgattatt ctttaggatg atacgttctt tttcaaatag ttttaggtga
     1201 ttaggtgatt cttttacaaa attggggata tcataattca aaaatttttc ttccatgtca
     1261 ctcatcttta cttgttaatc tacaataatc ctaccctaat ctttacgaaa taaaaatcta
     1321 ccagtagttt aatagtaagg aatattcaaa aaaattttat taattattat tttttagacc
     1381 gttttacttt tgcagcaact aagataagaa atagtgggat aataccggca actcgtccac
     1441 atttaaaaat atcaattacc aatagtaata atacaataaa aactagtatt gactttttca
     1501 tatttactcc ttaacttcaa aataaaaagt taagaaaaat cattaaataa aaatatactt
     1561 ttttaattta atttttccta gctttcttac cctattgatt ttaacgactt cttttacaac
     1621 gttttgttac caccaatgat tgataaacat attttatacc taagtaagca aaaaatatat
     1681 caataattgt aaataaaaaa tatcctttat caaaaaaaat acttcctact gctattgata
     1741 acattactaa accgatataa aaagtataat ttttataaaa ctttttattt attttcatat
     1801 attacttccc ctttccacta ataatttcag ctagattttt ttgttataca atttcatctc
     1861 ctagttttaa tttatcatat tattaaatca tcgtgcctaa attatcgaat ttggtctttt
     1921 tttagattta ttcggtaatc ttaattttat acatttttcg ctaatccata ttatctacat
     1981 atactaatat gtatggttat ataatttaca tcgtcaataa tcatttgcaa agataattat
     2041 ggaatgtcat ataaagagga ctggaatatc ctaagttcca accctattta ttaactatat
     2101 tttctaattt ctttaatcaa cataactata aaaatcatta atgttcccaa taagattaaa
     2161 cctctcattg ttaacatagg agttcgcata agcccattta aattcagtaa tattaacaat
     2221 agaaaacctg catacttact atttcttgta aaattcactt tcaacattga aattaccaca
     2281 aaccctacaa ctagtaatat aataatacct atttctacca tgtcattttc accacctata
     2341 tcaataaaca caaaagatta aactgttttc aaattatacc tttcaatcaa acttttcatt
     2401 ttagccttac ttcttctagg aaaagtctct ttatatccat ctttaaaaga aataaccctt
     2461 gttgacaggt taatttcaac aatattactt ggattagcta aacaagattg tgatattttt
     2521 tctagaaaat cattttctgc ctctaacttc ttaatatcgc ctgtaaactc acccatacca
     2581 ttaactgtaa ttatttttaa tctatgtgac ttaggagtgg taataatata tagaatatca
     2641 ttgatatttt cgttaataat tcttctgccc attttatagc taaatgtcat tttctttatg
     2701 gcatgagatt ccctaattct ccttgcagct aatgataaag tctcatttag tcgcttttga
     2761 atcacttcat cactatcatt tttagtaata aaatccaacg ctcctgtgcg acgtcgatag
     2821 gtcattgctg ctagattttc ataagccgta ataaaaatta tctgtgcatt gggatctttt
     2881 tgtctaataa attcagctaa atctatgcca tctttatctg ctctatccct actaagctcg
     2941 atatctaaaa aataaactcc actatctact ttgttatctt ctaaatagtc agctatttca
     3001 atataactat tagcttctaa agttatttta aactctttat ctttactatc agcagaatct
     3061 tctaaagacc aaatagcata tttaactaaa tcatgtatcc ttctaacttg atccttctca
     3121 tcgtcacaaa taataattcc atattcttcc aaattaaact accccttaaa tgctcataac
     3181 cataaggaaa gtaaaccaac catctttaat ttgataattg ataaaaatat cattataagg
     3241 ttgacttaat tcttctatat tagctaatcc taatccatca tgattcttct tagttgtaaa
     3301 acctgatttt ctcatatctt gaattgttaa gtctgtatct cgataacgat ttctaatctc
     3361 aatttcaagt tcaccatttt cttgataaat catagtatct atcttagctt catcaccaaa
     3421 ctcaagactt tcttcaattg cattatcgta cacaattcct aatattctaa caatgtcaaa
     3481 cgagttatac ttattcgaca agttttctat cacaattcga cattcaaaag aatattgaat
     3541 attgttttga aagattctat tcaacttact gataaataga ctctttaata attcatcttt
     3601 aacattgtca acatcattaa actgccataa tactttatct tctaaagtct tacttgaata
     3661 ttcagctagt ttatctatta actctttatc atgacttttt tttgcactga gtttcaagct
     3721 taatagcata ttttgataat cgtgcttaaa tttacgtaaa cctcgctggc tactttctaa
     3781 ctgttgtgta taaattttta gatcattaat ttgttgtaaa cttaatttat cctgccgtat
     3841 tttcttatta atggaatata caaataatga aaagaacaat tggctaacaa caactaccat
     3901 agctataata tacgatactg catctatatt aaatacatat gttgttagat agtaaataac
     3961 cattgaacta atccatatgt ataaaattaa ataaaaatac aataatccat actcatcatc
     4021 tagtttctct attatagtcg tctttgttaa aattatatat tcaaaaatgt ttaatgacac
     4081 atctaatatt atcacactga ccattgtgta ataatttgta aataatgtaa aaaataatgc
     4141 tgaagcaccg aatgttatgt aggaaaataa atctagcatt aacaaccttc cacataatct
     4201 gtaatccaaa gttagttgtc tgtatacaat ataaaaaata aaaatttcaa taaatggtgc
     4261 aaaaaaacca ataatatctc caacaccatt aattaaaaga attacaggaa aagtaagaag
     4321 tataaataat aaattatact tcttactttt cctagtaggg gtcaaaagat aaaaaaaact
     4381 atatctacaa aaagtattta taaataaaat tagtgtagct actatataac cagatgttga
     4441 atttaaatta accattattt acaaacacca aaaaatgtga atatacattg ccatctttta
     4501 aagcccccct ttttggttgc tcccccagct attttctgta acttcttttc tgttaacact
     4561 tcaaacttca taaaaaatct ctcctttgtt atctttatta caaatatagt ttaacatttt
     4621 ttaatctact ttattcgttt tttatcatat tcggttcatt ttaatgctta tttggatgaa
     4681 attcttaaaa ctatagccac cacataaaat ttaacaccca cgctctcaca taacttattt
     4741 tcttattctt ttctatgact ttctcatcaa ataacttata atgcccatct tcttttagac
     4801 tagtataaat acttataaag atactatatg caactattac agtaacccaa aataccatat
     4861 actcacttcc taatctcaaa atatattata ttaaaaataa taaaagtagt gtcaaattta
     4921 gctatatact ataacttaca cttgacacta cttgaagaaa aatagattta tttcttattt
     4981 tctaattcat tagacttatc ttaacggcaa cttgtaaaac caccagaaat tccacccgct
     5041 acggctgacc agggtccacc gatagctcca attaaagctc cacctacgat gccagctcca
     5101 cagtgaaccc agcgatttcc actaccacca taaccatttt taccaccatt tactgatgct
     5161 aagttatctt cagtcataat tgtgaatctt ttatctagat ttttcatctt aaatcacccc
     5221 tatattataa acaagtaagc gctccgccta ccattcctaa gtttgcccca cctacgatac
     5281 cagctggtcc aagtggaact cctgcagctg ctccagcaaa tagaccacct aagaagttac
     5341 ctacacagtt aggtccacgt ttcccaccat caacctttgc taattcacat tctgtcaata
     5401 ctgtaaattc cttcatcatg ataatcatcc tttcatatgt ttatttacct tcattgtagt
     5461 atctaataaa taaagtagtg tactaccacc tattagacaa aaaatagcaa ctattatcat
     5521 tttaggcgtc tggatataat ctaaataaga catatcctca ttaccaaaca accatattcc
     5581 tagtggaatc aatagtgccc aaataactgg agcaataaca tatctcttct ttcctctaat
     5641 gaatccacca tccaaccaag tctcccatag tttttttagc atgtaaaaac acatcctttc
     5701 taaaacactt gtgaaacata tcttacgctt ttattgtagt accatttaat acttgaatat
     5761 gaatttttcg taaaatacct tattttatgc ccagttggtt atctaatata aattctattg
     5821 taactataaa tattcatcat ttacgtggct tacttgtaac tataagtact atccctacaa
     5881 atattagaaa aatcgaatat attatgccac tccctagaag cacattgatt aaccctataa
     5941 gtatctaacc tatacctatg caatatctgt cttcttcatc tcatatattt atttactttc
     6001 atcgcggtat ctaacaagta aagtagtgta ctgccaccta ctagacaaaa aacagcaaat
     6061 attatccatt taggtatttg aatatagtct aaataagaca ttccttcatt gtcggatagc
     6121 cacatcgata ggggaagaaa tattgcaaaa ataattggaa tgattaccta tctcttcctt
     6181 cctctaatta atccgccatc taaccagata ttccataatt ttttcagcac atagaacaca
     6241 tcctctctaa aacacttgtg aaacatatgc ttacactttt attatattat cattccgtat
     6301 tcaaatatca atttagcata aaatgtttta tacctagttg gttacatttc tgtttaacta
     6361 caaatatttt gatttgaatg tcttaatctt ttgaaaaatt tggtattagc gattgtacat
     6421 cctatatcat aaccaaactg tccgctatct atataatcat aagaatttct tccaccaatt
     6481 atatgtgcta attctttctt atcaacttgt ataaaattat tattcataac ttcaacacct
     6541 cataatttta aaaatttatt atagctataa tttacactta taattattca cttcatctgc
     6601 tctttttgac tatttcttct aattttgcta aattttattc ttattctctt ttttcaacca
     6661 gataggcacc acttattacc aaattggaaa aatctcctca atttattact ttctatgtaa
     6721 taataaaaat acttttataa tgaattgagg taaaaagtat gaatagtttt tctaataata
     6781 ttaatttcag caaaatttct gtttcactaa ttactttact cctattgatc tggacattag
     6841 ttgatggaaa tctaattcat cttggtatac tagccttttc ttctttggtt acaaccatgc
     6901 tacattttca ctattttgaa tctactgatg acaagcatcc attaaataga attgattttg
     6961 tgttacagtt attatttatt tttatttcta tcattaaatt tttcttgatt tcaggaagat
     7021 aacaataagc ctatcaggta tcaaattaca cctgataggc ttatttatta acatatgtat
     7081 caacaatttt gtacttcttt ttaaattttc tttctggtat aattttgcga ttagtgaaat
     7141 ccaagtaatc gcctatatat ccaatgctaa atttcttaac tagcactatt tctcacctat
     7201 ttggcaaata gtccaaataa gtagttattg ctaccattcc agcagtttat cacactatgt
     7261 agacattatt tgcaataatt acatatatac gattaggggg attgaaaaat gagatacatt
     7321 aaatttactt tgctaatata ttctttttta ctaacttggg gaatcacgac gaatagtata
     7381 tcagcggatg aagtcacacc tactacaaca tctgaaacaa cagttacgtc tcaaagtcaa
     7441 agtatacctg ttgattctaa tgatgaagat gctgcaattg aagaaaaatt ttactctcat
     7501 gatgttacag tagatgaata taatcaaaat gtagccaact ttaacaaagt agatacgaat
     7561 actgttaaga acatggttac tgaaaatacc aataacttag accaagttct ttacattgga
     7621 cgtcctactt gttatttttg ccggcaagct tcaccacacc tacgtgattt taatcaacta
     7681 ataaataatc agctttacta ctatgatatt gatgctgaac ctaatgctca tgactttgcg
     7741 tttaaagaaa ttggaattcc tggaacacct acaactatgc gtttaaagaa tggtaagttg
     7801 gttagtgctt gggttggtgg cgaaaaaaca ggacaagaat tttacgactt tttatttttt
     7861 gcagatgcta acaaattggc agattcctat accataaaga aaactgtaag tgcaaatact
     7921 tcaaatactg ttattacaaa taatcaaaat gttaagccaa ctattaagcc tataccaaca
     7981 aacataaacc aacttaaaga ggaaaaaact actcctgaat tagttaatac tacttcacag
     8041 tcatctaaac ctgttaaaaa agttcagaaa caaactacta ataaagaaaa taaaaattct
     8101 gttctaccac agttaggggc tgtccctcct tatcatcagc cactatttaa acttcctatt
     8161 ccccgactta ttcctaagcg actagaacat attatagcgt tggtctcttt tctagttcta
     8221 tatattggta tcactatatg gacagggttg agtttaaaaa attgggataa aaaataaaat
     8281 atctaatata gcaataggac caatttttaa atttatgcaa aattatcgtt ttgatttaga
     8341 aaaatcaatt atttgcataa attttctaat tggtcctatc tttatattta acttttttca
     8401 aaatttgcaa ctttatttct catattaatt tttggggcca acttcaaata atatgctgtt
     8461 tactcttcag acactacccg atacttctta gcaaactttt cggctgtaac aaccttagaa
     8521 ttggtaaaat cgataacatc tccctcaaag ccaatatcat acatcgacgc gctgccacca
     8581 tttatactaa caagagaagc tgaaatacca ttcaaaatag ttcgtattat tccttttttt
     8641 gccctagtaa ctgccggcca ataaattctg actttattac cactaccatg cagccatcgt
     8701 aatccattat gctcaaaagc atattttacc caatcaggct ggatattatc tctactcact
     8761 tgccaaacat ctacttttct acctctatag attgctttca tttgctttat cacctttctt
     8821 attatttttt cctatcctta atagccataa ctaatctata catcactaag actatatata
     8881 ccaacaatgc tattaatact atcgtatata gtattttatt ttcatagcct tcatcaaata
     8941 ttgtagttac tattagaaat attcctaatg ttgcttgttt tctagctcgt ttatctaatt
     9001 caccatattt tttcttataa ttaacttcca aaattgctga tagtataaag aatatccaaa
     9061 taattgcctt aataactaaa taatccatca ttccaccatc tattctctat ttttgccatt
     9121 attatactat tttaattaaa tttaattctg tattttctta attaacactc ttttctgctt
     9181 atttggttca tatccatgta tgttaaaaaa tagcgacaaa aacatcgctg tcttgccact
     9241 attcccaact atttaaataa attaagtttt gcgattctat caactgcttc ttctaagcgt
     9301 tctggttcaa ttaacaaacc aattcgtaca taaccttctc catattcgcc aaaaccattc
     9361 ccaggagcta ctgctactcc agcttcattc aaaagtagat ctgcaaattc ttcactacta
     9421 tatccctttg gtacttccat ccaagcgtag aaagttccct taggtacaaa agctttccat
     9481 ccgatttttt cagcagcttg aatgaacgca ttccttctag tttcgtaacg atctacaatc
     9541 ttattaatct cggcatcgcg ttctggagct ttcaaagcat caattcctgt atattgtaga
     9601 gctggaaaga tacttacaaa taaatgatct tggataagat ttaaagcatc aatgatatca
     9661 gcatttccta ccgcaaaagc aactcgccaa cctgccatat taaaagtctt agagaaggta
     9721 taaaattcga taccaacatc cttagctccc ggaatctcca taaaacttag tggttgctct
     9781 ccatcaaaac caattgcacc ataagcaaaa tcgctgatga tacctacttc atatttcttt
     9841 gcccaagcga ctaattcttc gtaaaattct cgggttgcag tcgcacctgt cggattatta
     9901 ggatagttaa tatagaaaaa tttagctttt ttggcaagtt cttcaggaat agattttaaa
     9961 tctggtaaga aattattctc cttcaaaagt ggaactttct caaaagttac ctgtccaagt
    10021 gtagctccag accaataatc tggataacca ggatctggta ataaaaatac atcgccagga
    10081 ttcatcaaag ccagtggtag ttcgactaag cccgttttag agccaccaag aactgcaact
    10141 tctttttctg gatcaaatat agtttgatac ttttcttgat aaaaatctgc tatagcttgt
    10201 ttaaaatctg gttgtccacg aaacaatgag tacttgtgac tttgcggact agctacccat
    10261 ttttgtgtgc tcttaacgat atattcagga gtttgtttat caggattacc ttgtcccaga
    10321 ttgataacat ctactccttc tgcaattttt ttgttaactt tgattaccaa attagcaaaa
    10381 aattgctttg gtagattttt tagaatttca gatttttca
//
