LOCUS       NZ_CP023565.1           8793 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP023565.1 Ligilactobacillus murinus strain CR147 chromosome,
            complete genome.
ACCESSION   NZ_CP023565
VERSION     NZ_CP023565.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:28:34
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1678609
            Orig. end    :: 1687402
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..432)
                     /locus_tag="ctg1_1619"
                     /transl_table=11
                     /translation="MKSKVEIDPKLPEEWAEFHVHELTPKLQQVVQLLEHDEQIWGYAD
                     QIVKPLALAQIISLNSQAGKIYAMTEHGSYQVKKKLYEVAELLSPDFVKISRSEFVNLN
                     YLDHLELTAQGTIALKLKNGTTTFVARRCVKNLKERLGI"
     protocluster    1..8793
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1683512:1683776](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4904..5167)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..8793
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8793
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     complement(10..285)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1619_0072"
                     /evalue="7.20E-18"
                     /label="ctg1_1619"
                     /locus_tag="ctg1_1619"
                     /protein_end="141"
                     /protein_start="49"
                     /score="64.7"
                     /tool="antismash"
                     /translation="PLALAQIISLNSQAGKIYAMTEHGSYQVKKKLYEVAELLSPDFVK
                     ISRSEFVNLNYLDHLELTAQGTIALKLKNGTTTFVARRCVKNLKERL"
     CDS             complement(697..960)
                     /locus_tag="ctg1_1620"
                     /transl_table=11
                     /translation="MVEKLKQYPVTALTVVAMVLIALLLGELAWFRKLAVVLLTWWVGV
                     GFERPVNEMIAQEKLGKLVGKGFVLVATVAFAAVVTYVQIRF"
     CDS             complement(972..1349)
                     /locus_tag="ctg1_1621"
                     /transl_table=11
                     /translation="MFIHHIAIICSDRAQAVDFYVDKLGFEIISEHVRPKKDDILLNVA
                     KDGLVLELFIKPNARKRVSGATGEARGLRHLAFKCDDVAAKREQLLALGIKCEPLRRDD
                     FDGKLMTFFFDPDGLPLELHE"
     PFAM_domain     complement(981..1343)
                     /aSDomain="Glyoxalase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00903.27"
                     /description="Glyoxalase/Bleomycin resistance
                     protein/Dioxygenase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1621_0073"
                     /evalue="4.50E-16"
                     /label="ctg1_1621"
                     /locus_tag="ctg1_1621"
                     /protein_end="123"
                     /protein_start="2"
                     /score="59.3"
                     /tool="antismash"
                     /translation="IHHIAIICSDRAQAVDFYVDKLGFEIISEHVRPKKDDILLNVAKD
                     GLVLELFIKPNARKRVSGATGEARGLRHLAFKCDDVAAKREQLLALGIKCEPLRRDDFD
                     GKLMTFFFDPDGLPLEL"
     CDS             complement(1349..1783)
                     /locus_tag="ctg1_1622"
                     /transl_table=11
                     /translation="LKEAKHKMHKPHFIHDIRIGIGDMCKITGVTGRQLRYWEERGYIK
                     SLADEKNSARKYSWEMLYKVGSIKAFIDEGYTLAKAVEKSELREKEMAIIRKFMATNMH
                     RVKITDEELLYGQIDLGKCEGKKIYGVVDEAGSHLEFGEE"
     PFAM_domain     complement(1541..1723)
                     /aSDomain="MerR_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13411.8"
                     /description="MerR HTH family regulatory protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1622_0074"
                     /evalue="3.30E-11"
                     /label="ctg1_1622"
                     /locus_tag="ctg1_1622"
                     /protein_end="81"
                     /protein_start="20"
                     /score="43.2"
                     /tool="antismash"
                     /translation="IGDMCKITGVTGRQLRYWEERGYIKSLADEKNSARKYSWEMLYKV
                     GSIKAFIDEGYTLAKA"
     CDS             1937..3424
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 321.6; E-value:
                     1e-97)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1623"
                     /transl_table=11
                     /translation="LNNATRPTDINGNGYNRDLLVLVLMVGSFCTFLNSTLMNTAFPAI
                     MKDFSISTATVQWLTTGFMMVNGVMIPISAWLINRFSSKTMYLWAMLTFLLGTVVSFTA
                     QNFGVLLAGRLIQGIGVGVSMPLLQTIMLSIFPPEKRGAAMGTVGLVIGLAPALGPTLS
                     GWIVDNWTWRELFGMIIPIVVAVIILAFFFMKSVVPNTHQKIDVISIITSTIGFGALLY
                     GFSKAGNDGWGDLYVLVYLAVGAVFVALFCLRQLKMDEPFLDITVFKYGEFSLAAILSG
                     VANLALVGSEMVIPLYIQNIRGESAFHSGLILLPGALAMGIMSPITGRLFDRYGAKFMA
                     LAGMTMLTLGSIPFLFITKETSIMLIIVFYAIRMFGISATMMPVTTSGMNVLPFNKISH
                     GTAVNNTFRQVLSSIGTAILISVLSSVTKNSMPAHNVLVQTPIKYADLATGAVLNGYHA
                     AFFISILFAVVALCFAFFLKKGNNAPKVTLTSKKGAK"
     aSDomain        1994..3220
                     /aSDomain="TIGR00711"
                     /aSTool="tigrfam"
                     /description="efflux_EmrB: drug resistance MFS transporter,
                     drug:H+ antiporter-2 (14 Spanner) (DHA2) family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1623_0021"
                     /evalue="1.90E-110"
                     /identifier="TIGR00711"
                     /label="ctg1_1623"
                     /locus_tag="ctg1_1623"
                     /protein_end="428"
                     /protein_start="19"
                     /score="367.8"
                     /tool="antismash"
                     /translation="LVLVLMVGSFCTFLNSTLMNTAFPAIMKDFSISTATVQWLTTGFM
                     MVNGVMIPISAWLINRFSSKTMYLWAMLTFLLGTVVSFTAQNFGVLLAGRLIQGIGVGV
                     SMPLLQTIMLSIFPPEKRGAAMGTVGLVIGLAPALGPTLSGWIVDNWTWRELFGMIIPI
                     VVAVIILAFFFMKSVVPNTHQKIDVISIITSTIGFGALLYGFSKAGNDGWGDLYVLVYL
                     AVGAVFVALFCLRQLKMDEPFLDITVFKYGEFSLAAILSGVANLALVGSEMVIPLYIQN
                     IRGESAFHSGLILLPGALAMGIMSPITGRLFDRYGAKFMALAGMTMLTLGSIPFLFITK
                     ETSIMLIIVFYAIRMFGISATMMPVTTSGMNVLPFNKISHGTAVNNTFRQVLSSIGTAI
                     LISVLSSVTK"
     PFAM_domain     2006..3181
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1623_0075"
                     /evalue="2.00E-51"
                     /label="ctg1_1623"
                     /locus_tag="ctg1_1623"
                     /protein_end="415"
                     /protein_start="23"
                     /score="175.1"
                     /tool="antismash"
                     /translation="LMVGSFCTFLNSTLMNTAFPAIMKDFSISTATVQWLTTGFMMVNG
                     VMIPISAWLINRFSSKTMYLWAMLTFLLGTVVSFTAQNFGVLLAGRLIQGIGVGVSMPL
                     LQTIMLSIFPPEKRGAAMGTVGLVIGLAPALGPTLSGWIVDNWTWRELFGMIIPIVVAV
                     IILAFFFMKSVVPNTHQKIDVISIITSTIGFGALLYGFSKAGNDGWGDLYVLVYLAVGA
                     VFVALFCLRQLKMDEPFLDITVFKYGEFSLAAILSGVANLALVGSEMVIPLYIQNIRGE
                     SAFHSGLILLPGALAMGIMSPITGRLFDRYGAKFMALAGMTMLTLGSIPFLFITKETSI
                     MLIIVFYAIRMFGISATMMPVTTSGMNVLPFNKISHGTAVNNTFRQVLSSIG"
     CDS             3425..4138
                     /locus_tag="ctg1_1624"
                     /transl_table=11
                     /translation="MSIIILVLATISFFCFTVLPTLKHHVLYALLSFAIMVLCTGAIVL
                     NDSYNFGMKVQTITQKQKLVSSVPDQLDVLLYQPLGTKSERVYLYHNSSDEKKLRQTKT
                     TDTTTKYSQTGKTPQLVVTKERYVYQNGLSELFFGILGNNDRLKHQTYEFKLTDNWFVL
                     STKQAKQLKKLLKEHDTELKQNISQVIQQELAQKLQQNPTMSSSEREKLVKELQKQATQ
                     QLVKKLITQVQASDS"
     PFAM_domain     3494..3937
                     /aSDomain="DUF4811"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF16069.7"
                     /description="Domain of unknown function (DUF4811)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1624_0076"
                     /evalue="6.80E-43"
                     /label="ctg1_1624"
                     /locus_tag="ctg1_1624"
                     /protein_end="171"
                     /protein_start="23"
                     /score="146.3"
                     /tool="antismash"
                     /translation="HHVLYALLSFAIMVLCTGAIVLNDSYNFGMKVQTITQKQKLVSSV
                     PDQLDVLLYQPLGTKSERVYLYHNSSDEKKLRQTKTTDTTTKYSQTGKTPQLVVTKERY
                     VYQNGLSELFFGILGNNDRLKHQTYEFKLTDNWFVLSTKQAKQL"
     CDS             4235..4483
                     /locus_tag="ctg1_1625"
                     /transl_table=11
                     /translation="MDKQTNIVSAQVVDVKSNKITLKTEDDEVIEVARPKSAAHDMLFI
                     QTMKDILKSGIWIPVNKKLKQLLRYDWFETPVEQYSF"
     CDS             complement(4904..5167)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_II"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1626"
                     /sec_met_domain="Bacteriocin_II (E-value: 2.4e-12,
                     bitscore: 43.4, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKILICLVTVLSLVFVFGLHNTASASVSANVPVTGGSSADPYKY
                     YGNGLYCNQLGCKVDWSRTWYCGVNNAAAGYATGGKAGIENC"
     PFAM_domain     complement(4934..5038)
                     /aSDomain="Bacteriocin_II"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01721.20"
                     /description="Class II bacteriocin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1626_0077"
                     /evalue="5.80E-11"
                     /label="ctg1_1626"
                     /locus_tag="ctg1_1626"
                     /protein_end="78"
                     /protein_start="43"
                     /score="42.3"
                     /tool="antismash"
                     /translation="KYYGNGLYCNQLGCKVDWSRTWYCGVNNAAAGYAT"
     CDS             complement(5336..5584)
                     /locus_tag="ctg1_1627"
                     /transl_table=11
                     /translation="MLISFPPSKAPASAIKALKGRSAYIFLQNHPEIRRSQYWGGHLWS
                     PSYYMSTLGNMSKEVVEKYINDQKYTETNKKPHKGAQ"
     PFAM_domain     complement(5381..5584)
                     /aSDomain="Y1_Tnp"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01797.18"
                     /description="Transposase IS200 like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1627_0078"
                     /evalue="8.90E-19"
                     /label="ctg1_1627"
                     /locus_tag="ctg1_1627"
                     /protein_end="68"
                     /protein_start="0"
                     /score="67.9"
                     /tool="antismash"
                     /translation="MLISFPPSKAPASAIKALKGRSAYIFLQNHPEIRRSQYWGGHLWS
                     PSYYMSTLGNMSKEVVEKYINDQ"
     CDS             complement(5648..5791)
                     /locus_tag="ctg1_1628"
                     /transl_table=11
                     /translation="MTKEKIKEAIYTRRYIYNFHYHLIWVTKYRNQTFTTEALSNEMKA
                     IL"
     PFAM_domain     complement(5654..5743)
                     /aSDomain="Y1_Tnp"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01797.18"
                     /description="Transposase IS200 like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1628_0079"
                     /evalue="4.50E-06"
                     /label="ctg1_1628"
                     /locus_tag="ctg1_1628"
                     /protein_end="46"
                     /protein_start="16"
                     /score="26.9"
                     /tool="antismash"
                     /translation="YNFHYHLIWVTKYRNQTFTTEALSNEMKAI"
     CDS             5865..7115
                     /gene_functions="other (smcogs) SMCOG1192:transposase
                     (Score: 262.5; E-value: 1e-79)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1629"
                     /transl_table=11
                     /translation="MKSMAKMKYHYGLKMRCYPSDQQKQLIKINSDASRFIYNEMVAIN
                     KELMQLRRVKLPIDIVRDRIKQLTMRQNAKQMSNHYQFLEDKRIDSLTKANAIQNYRKA
                     WNAFRKVHTAGVPKFHRKNYRWRYQTNCQYPGQKTALLTNGTVCFLDNSHVKVPKIGLL
                     RVAGSQARLLKRICETRIGTVTLTKDSADRFFLSMQLASDESFVKVAKATHGHVGIDLN
                     TDNFLTDSGGNIVPNPRYYRTIKGKLAKEQRILSRRQQRAKKEHRSLRDSKNYQKQRLL
                     VAKLHAKVMNQRHNFLQQISTALIKNHDLVVAEELRSKNMLKNHALALSISDVGWRTFL
                     GMLAYKAKLYGRQFITINPRNTTQTCCDCGFVMGTNGTDKLTLDDRKWTCPNCGIHHIR
                     DWNAAKNILDKGIAKLA"
     PFAM_domain     5898..6014
                     /aSDomain="HTH_OrfB_IS605"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12323.10"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1629_0080"
                     /evalue="9.70E-07"
                     /label="ctg1_1629"
                     /locus_tag="ctg1_1629"
                     /protein_end="50"
                     /protein_start="11"
                     /score="28.3"
                     /tool="antismash"
                     /translation="GLKMRCYPSDQQKQLIKINSDASRFIYNEMVAINKELMQ"
     PFAM_domain     6501..6830
                     /aSDomain="OrfB_IS605"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01385.21"
                     /description="Probable transposase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1629_0081"
                     /evalue="2.10E-17"
                     /label="ctg1_1629"
                     /locus_tag="ctg1_1629"
                     /protein_end="322"
                     /protein_start="212"
                     /score="63.5"
                     /tool="antismash"
                     /translation="THGHVGIDLNTDNFLTDSGGNIVPNPRYYRTIKGKLAKEQRILSR
                     RQQRAKKEHRSLRDSKNYQKQRLLVAKLHAKVMNQRHNFLQQISTALIKNHDLVVAEEL
                     RSKNML"
     aSDomain        6735..6950
                     /aSDomain="TIGR01766"
                     /aSTool="tigrfam"
                     /description="tspaseT_teng_C: transposase, IS605 OrfB
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1629_0022"
                     /evalue="9.10E-10"
                     /identifier="TIGR01766"
                     /label="ctg1_1629"
                     /locus_tag="ctg1_1629"
                     /protein_end="362"
                     /protein_start="290"
                     /score="36.9"
                     /tool="antismash"
                     /translation="NQRHNFLQQISTALIKNHDLVVAEELRSKNMLKNHALALSISDVG
                     WRTFLGMLAYKAKLYGRQFITINPRNT"
     PFAM_domain     6870..7094
                     /aSDomain="OrfB_Zn_ribbon"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07282.13"
                     /description="Putative transposase DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1629_0082"
                     /evalue="2.40E-21"
                     /label="ctg1_1629"
                     /locus_tag="ctg1_1629"
                     /protein_end="410"
                     /protein_start="335"
                     /score="75.5"
                     /tool="antismash"
                     /translation="WRTFLGMLAYKAKLYGRQFITINPRNTTQTCCDCGFVMGTNGTDK
                     LTLDDRKWTCPNCGIHHIRDWNAAKNILDK"
     CDS             complement(7589..8032)
                     /locus_tag="ctg1_1630"
                     /transl_table=11
                     /translation="MLKQVLARPAVYKKILLGYWIGSSVILFGYLSLVALDLGKSLPAT
                     LQTMPSLALVTIIAGLNLLLAAALWKIQATDRPLFLSLALVQQLLSLNFVGALLIYFYQ
                     RFSQQKFLQKPTTDQGALLLSFTLVILLTLFVLLIRLRLEFIN"
     CDS             complement(8038..8793)
                     /locus_tag="ctg1_1631"
                     /transl_table=11
                     /translation="MTLEELITKHQKALGDLDKTILRYVLDNKQEVQQLGITELATATY
                     TSKSTVLRLVRKLGFAGFSEFKYFLKTSTKEVKPATEMFADLQVSDIIKTIKGLEHVEW
                     DDLTLRLKEAQTIYCYGTGFSQRRILDEFAKNLLQLGKRAITIPNKTELDMAMEMITTH
                     DVVLLASLSGETESIKENIFMWTLKNVPLVSVTQAKENTFASHSDYALHYHVTPFSVIK
                     EKKVESLVTLSVVVDYLFRKLTEKMSKDR"
     PFAM_domain     complement(8140..8463)
                     /aSDomain="SIS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01380.24"
                     /description="SIS domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1631_0084"
                     /evalue="4.90E-12"
                     /label="ctg1_1631"
                     /locus_tag="ctg1_1631"
                     /protein_end="218"
                     /protein_start="110"
                     /score="45.9"
                     /tool="antismash"
                     /translation="LKEAQTIYCYGTGFSQRRILDEFAKNLLQLGKRAITIPNKTELDM
                     AMEMITTHDVVLLASLSGETESIKENIFMWTLKNVPLVSVTQAKENTFASHSDYALHYH
                     VTPF"
     PFAM_domain     complement(8575..8793)
                     /aSDomain="HTH_6"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01418.19"
                     /description="Helix-turn-helix domain, rpiR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1631_0083"
                     /evalue="3.00E-17"
                     /label="ctg1_1631"
                     /locus_tag="ctg1_1631"
                     /protein_end="73"
                     /protein_start="0"
                     /score="62.5"
                     /tool="antismash"
                     /translation="MTLEELITKHQKALGDLDKTILRYVLDNKQEVQQLGITELATATY
                     TSKSTVLRLVRKLGFAGFSEFKYFLKTS"
ORIGIN
        1 ttatatccct agcctttctt tgagattttt gacacaacgc ctagctacaa aggtcgtagt
       61 accatttttt agttttaaag cgatcgttcc ttgcgcggtc aattccaaat gatctaaata
      121 attcaagtta acaaattcac tacgactgat cttaacaaaa tctggggata aaagttcagc
      181 cacttcatat aatttcttct ttacctgata gctaccgtgc tcggtcatag catagatctt
      241 accagcttgg ctatttaagg aaattatctg agctaaagct aacggcttaa cgatctgatc
      301 ggcatagccc caaatttgtt catcgtgttc aagtagttgg acgacttgtt gtaacttagg
      361 tgtcaattca tgcacatgaa attcggccca ttcttcaggt aatttcggat cgatctcaac
      421 tttacttttc attttggcat ccccctttct ttaactaaat tctagcaaat cttaggctaa
      481 atttcgctaa agacgcctaa acggtcagga ctgacaggca aacggtctaa aagctagctc
      541 aagcgggtct aaaaggtcgt aatgtgatag ttatgtagta gaaacgtgtt ttacagcaca
      601 cctagctgat aacgagagat cccccatgtt gcaaaatacg catcatgggg gatctctcgt
      661 tatctgtacg gaactacccg tgctgtttca cacgctttaa aatcttattt gaacataggt
      721 cactacggct gcaaaagcta ctgtcgctac caaaacaaag cccttgccta cgagctttcc
      781 taatttttct tgggcgatca tctcattgac gggcctttca aagccaactc cgacccacca
      841 agtcaataag accaccgcta atttcctaaa ccaagccagc tcacctaaca acaaagctat
      901 cagcaccatt gctactacag taagcgctgt gactggatat tgctttaatt tttctaccat
      961 tatgtctcct tctattcatg taattcaagg ggcaagccgt cagggtcaaa gaaaaaggtc
     1021 atcaacttac catcgaagtc atcacgccgc aacggctcac atttgatacc taacgccaac
     1081 aattgctctc ttttggctgc aacatcgtca catttaaagg ccaaatgccg taaaccccgt
     1141 gcctcacccg tagcaccact gacacgtttt cgggcattgg gcttgatgaa caactccaag
     1201 actagcccat ctttagctac attcaacaaa atatcgtctt ttttgggacg gacatgttca
     1261 gatatgatct caaaccccaa tttatcaaca taaaaatcaa ctgcttgtgc acgatcgcta
     1321 caaatgatcg caatatgatg gataaacatt actcttcacc aaattccaaa tgactgccag
     1381 cttcatcaac aacaccgtag atctttttac cttcacattt tcctaagtca atttgcccgt
     1441 agagtagctc ttcatctgtg atcttcactc tatgcatatt ggtagccata aatttacgga
     1501 tgatcgccat ttctttttcg cgtaattcag atttttcaac agctttagct aaggtatagc
     1561 cctcatcaat aaaagctttg atcgaaccaa ctttatacag catttcccag ctatacttac
     1621 gcgcggaatt cttttcatcg gctagcgact tgatataacc ccgctcttcc caatagcgca
     1681 attggcgccc tgtaactcca gtgatcttgc acatgtcacc gatcccgatc cgaatatcat
     1741 ggataaagtg gggtttgtgc atcttatgct tcgcttcttt caaggttctt ccccctcgca
     1801 aatagtttct cactttagat tttatattgt ttgggcgatt tgtcaactat cttgacaaac
     1861 ttggtaaata aggtttatag taggcaacgc acataaattg aaaataatat ctaaaatact
     1921 aaaggagtga acttgcttga ataatgctac gcgtccgacc gacatcaatg gcaatggtta
     1981 taatcgtgat ctattggtct tagttctaat ggtcggttct ttttgtactt ttttgaatag
     2041 taccttgatg aatactgctt ttcctgcgat catgaaagat ttttcgatct caacagcaac
     2101 cgttcaatgg ttaacgactg gttttatgat ggtcaatggg gtaatgatcc cgatctcagc
     2161 ttggttgatc aatcgtttca gctcaaaaac gatgtatctc tgggctatgt tgaccttttt
     2221 actagggaca gtcgtttctt ttaccgccca aaatttcggc gtccttctcg caggtcggtt
     2281 gatccaaggt atcggggtcg gcgtctcaat gccgttactt caaacgatca tgctctcgat
     2341 ctttcctcca gaaaaacggg gcgctgccat ggggacagtc gggctagtga tcgggcttgc
     2401 accagctttg gggccaacac tttccggctg gatcgtcgat aactggactt ggcgtgaatt
     2461 atttggcatg atcattccga tcgtggtcgc cgttatcatc ttagcctttt tcttcatgaa
     2521 aagcgttgtg cctaacaccc accaaaagat cgacgttatt tcgatcatca cctcaacgat
     2581 cggatttggg gcgttattat atggtttttc taaagctggt aatgatggct ggggcgatct
     2641 ttatgtcctc gtctatctag ctgtcggggc agtctttgtt gctctctttt gtttacgcca
     2701 attaaaaatg gacgaacctt tcttagatat cacggtcttt aaatatggtg aatttagctt
     2761 agctgcgatc ttaagtgggg tggctaactt agctttggtt ggttctgaaa tggtgatccc
     2821 actttacatt caaaacattc gcggggaatc cgccttccat tccggcttga tcttactccc
     2881 tggtgccttg gccatgggaa tcatgtcacc gatcacaggg cgcttgtttg accgttacgg
     2941 ggctaaattt atggcgcttg ctgggatgac gatgttgact ttaggctcga tcccctttct
     3001 ttttatcact aaagagactt cgatcatgtt gatcatcgtc ttttatgcga tccggatgtt
     3061 tgggatctcg gcgacgatga tgccggtcac gacttctggg atgaacgtct tgcccttcaa
     3121 caagatctct cacggaacag cggtcaacaa cactttccgc caagtcttaa gctcgatcgg
     3181 gaccgcgatc ttgatctccg tcttgagttc agttaccaaa aactcaatgc ctgctcacaa
     3241 tgttttggtc caaacgccga tcaaatatgc tgatcttgca acaggagctg ttttgaatgg
     3301 ttatcatgct gcattcttta tctcgatcct ctttgcagtc gtcgcattgt gctttgcttt
     3361 cttcttaaag aagggcaata atgcacctaa agtcacactc actagtaaaa agggggctaa
     3421 gtagatgagt atcattattt tagttttagc aacgatcagc ttcttttgtt ttacagtcct
     3481 gcctaccctt aaacaccacg ttttatatgc tttactatca tttgcgatca tggtgctttg
     3541 tactggtgcg atcgttttga atgattccta taattttggg atgaaagttc aaacgatcac
     3601 ccaaaaacaa aaactcgttt cttcggttcc tgatcaactc gatgtcttat tgtatcaacc
     3661 acttggaact aagtcagaaa gagtctatct ctatcacaat tcttctgatg agaagaaatt
     3721 gcgccaaaca aaaacgactg atacgactac caaatactcg caaactggca aaactccaca
     3781 attagtcgtg acaaaagagc gttatgtcta ccaaaatggc ctttctgagc ttttctttgg
     3841 tatcttaggc aataatgatc gtctcaaaca tcaaacttat gagttcaaat tgaccgataa
     3901 ttggtttgtt ttgagtacta agcaagctaa acagctaaaa aaattactta aagaacatga
     3961 taccgaactc aagcaaaaca tctcccaggt catccaacaa gaattagctc agaaattgca
     4021 acaaaatcca acgatgtcta gctcagaacg cgagaaattg gtcaaagagt tacaaaaaca
     4081 agcgacccaa cagttagtca aaaaattgat cactcaagtt caagcaagtg attcttaaac
     4141 taaatctaag gcatatttat aaacaaattt aaacaactag cgtatagtag agactgtatc
     4201 aagttaagat acccgtccag aaaggaacat ctatatggat aaacaaacta atattgtctc
     4261 tgcacaagtt gtagacgtaa aatcaaacaa gatcacttta aaaactgaag acgatgaagt
     4321 tatcgaagtg gcacgcccta aaagcgcagc ccatgatatg ctcttcatcc aaacaatgaa
     4381 agacatctta aagagtggga tctggatccc ggtaaataaa aaactcaaac aacttttacg
     4441 ttacgactgg tttgaaactc cagtcgaaca atactcattt taatataaaa aacgggctga
     4501 aaatcgcgtt taaaacgttg atcttcaacc cgtttttttg tatgagtttt tcctagtttc
     4561 taatttttat gctcaaattt ttggggatcg attttttatc ttccaagcca agtgttagtg
     4621 gtcataaggt cgttgatttt agtccaaata ctacctgaat ttgatatttt ttttagttga
     4681 tataaaagtt cctttgtttc tttagataga gacttttttt caattaaatt taacgtaaaa
     4741 aagttttgat atacaacatt tacttccgta cgaatagtat agttattctt aattttctcg
     4801 ctggctatat caatgaaatt aagatcagaa ttggaaaatc catctgcttc taaactatat
     4861 ttgaaagatt ttaacaataa aagtacatca tcttttttta cagttaacaa ttttcaatac
     4921 ccgctttccc accagttgca tagccagctg ctgcattatt tactccacaa taccatgttc
     4981 tagaccaatc gactttacag cctaattgat tacaataaag cccattacca taatatttat
     5041 atggatcagc agaacttcct ccagtcacag gaacatttgc cgaaacacta gccgaagcag
     5101 tgttatgaag cccaaataca aaaacgagag ataatactgt caccaaacaa attaatattt
     5161 ttctcatgat gcaactcctt tttgtaattc aactgacaac tactacaact attaaaccta
     5221 ctttgttcaa attttaccac actaataaac caatgtaaat ttaatgaaag tggtcctaat
     5281 cacttttaat gacgcctatc catcccgtga ctttagtcat gggatggata ggccactatt
     5341 gagccccttt atggggcttt ttgtttgttt ctgtatattt ttggtcattg atatatttct
     5401 ctacaacttc tttgctcata ttgcccaatg tactcatata gtaacttggc gaccaaagat
     5461 gaccgcccca atattggcta cgtcgtattt ctggatgatt ttgtaaaaaa atataggcac
     5521 tacgtccttt gagcgcctta atggcactag ccggcgcttt gcttggcgga aaactgatca
     5581 gcatatgaat gtgatccggc atgacttcca tcttttcgat tacgatgtca ttgttatctg
     5641 caacttgcta caagatagct ttcatttcgt tagataaggc ctcggttgta aaagtctgat
     5701 tgcgatattt agttacccag atcaaatggt aatggaaatt atagatataa cgacgagtat
     5761 aaatggcctc tttgattttt tctttagtca taatatggtc tcctttgtta atacattgac
     5821 atcatgatat aatgttatta tatcaataag ggaggtgaaa tcaaatgaaa tcaatggcaa
     5881 aaatgaaata tcattatggc ctaaaaatgc gctgctatcc tagtgaccaa caaaagcagt
     5941 tgattaaaat caacagtgac gctagtcgct ttatctataa cgaaatggtt gcaatcaata
     6001 aggaactgat gcagcttcgc agagttaagc taccgattga catagttcgg gatcgtatta
     6061 agcaactaac tatgcgccaa aacgctaagc aaatgtctaa tcactatcaa ttcttagaag
     6121 ataaacgaat tgatagtttg acgaaagcta atgccattca gaactatcgg aaagcttgga
     6181 atgcttttcg gaaggttcac accgctggtg ttcctaagtt tcatcgaaag aattatcgct
     6241 ggcgttatca aaccaattgt caatacccag ggcaaaagac tgcgttgcta actaacggta
     6301 cagtctgttt tctagataat agccatgtca aagtccctaa aatcggactg ttacgtgttg
     6361 ccggttcgca agcacggctt ttgaaaagaa tatgcgagac tagaattggt actgtgacgt
     6421 tgactaaaga ttcagcggat cgcttcttct tatcaatgca gttagcttca gatgaatctt
     6481 ttgttaaagt ggccaaagct actcatgggc atgttggaat tgatcttaat actgataact
     6541 tcttaaccga cagtggaggt aacatagttc ctaatccacg atattatcgc actattaaag
     6601 gtaaattagc caaagaacag cgcattttat ctagacggca acaacgtgca aaaaaagaac
     6661 atcgttcctt acgcgatagt aaaaattacc aaaagcaacg cttgctagtt gccaaacttc
     6721 atgccaaagt aatgaaccaa agacataatt ttctccaaca aatctctact gcattaatca
     6781 agaaccacga tttagtagta gccgaagagt tgcgtagcaa gaatatgctt aaaaatcatg
     6841 ctttagcact tagtatttct gacgttggtt ggcgaacatt tcttggcatg ttggcttata
     6901 aagcaaagct ttatgggcgt caatttatca caatcaatcc aagaaacacc acccaaacat
     6961 gttgcgattg tggctttgtg atgggcacta atgggacgga caaactaacg ttagatgacc
     7021 gaaaatggac ttgtcctaac tgtggtattc accatattcg tgactggaac gcagctaaaa
     7081 atattcttga taagggaata gctaaactag cttagcttat ctgtccctat ggcaacctgg
     7141 ggacataaaa ggcgttggta attagacgac cgctgtttga ttacaatttc ggttggtcaa
     7201 ataagttgtc cctatctacg caaattgtgg ttcgaaatct gtaaggattt tcggctcaca
     7261 agccactgac tttagtcagt ggtggttgac caagcatcaa ttgtagcttg agatcattgt
     7321 agttttttta aactaatatt ttgttttgct gatcgcattt attctgcttc tctcagtgac
     7381 ctttcagttt tcagcgcaaa ctatagcaca acatccgttt ttgtgtaaac aatctcctaa
     7441 aataaatctc ccttaacttt cagtaaatag cactatgttt gtagtcatgt tccgaattac
     7501 aactcttagg aaatagcggt gtcctacctt catctcaaag atagaacacc gctatttcta
     7561 cgcaactaaa cgcaattttt gcactgtgtt agtttataaa ctccaatctg agcctgatca
     7621 agagaacaaa aagtgtcagc aatatgacca gcgtaaagga aagtagcaac gcaccttgat
     7681 ctgttgttgg cttttggaga aacttctgtt gactgaaacg ttggtaaaaa tagatcaata
     7741 acgctcccac aaagtttaaa ctcaagagtt gttgtaccaa agctagactt aaaaatagtg
     7801 gcctatctgt cgcttggatc ttccataagg ctgctgctaa taataagttg aggcctgcaa
     7861 tgatcgttac taaggctaag ctaggcatcg tctgtaaagt cgctggcaaa cttttgccaa
     7921 ggtcaagcgc gaccaaagat agatatccaa ataagatcac acttgaaccg atccagtagc
     7981 ctaataagat cttcttgtat acagctggtc ttgccagtac ttgttttaac atttttctca
     8041 cctatcttta ctcatttttt cggtcaactt tcgaaaaaga taatcaacga caactgataa
     8101 tgtgactaat gactcgacct ttttttcttt gataacggaa aatggcgtca catgatagtg
     8161 caaagcataa tccgaatgac tcgcaaacgt attctccttt gcttgcgtca cactcacaag
     8221 agggacattt ttcaaggtcc acatgaagat gttttctttg atgctttcag tttctccact
     8281 aagtgacgcc aataaaacaa catcgtgtgt agttatcatc tccattgcca tatcaagttc
     8341 agtcttatta gggatcgtga tcgcccgttt tcctagctgt aacagatttt tagcaaattc
     8401 atctaagatc cgccgttggg aaaaacctgt gccgtagcaa tagatcgttt gggcctcttt
     8461 gagccgtaat gttagatcgt cccattcgac atgttctaag cctttgatcg tcttaatgat
     8521 atctgagacc tgtagatcgg caaacatctc tgtggctggt ttgacctctt tagtgctcgt
     8581 ctttaaaaag tatttgaatt ccgagaaacc tgcaaaacct aattttctga ctaaacgtaa
     8641 aactgttgat ttggaagtat aagttgctgt agctaattca gtgatcccca actgttgaac
     8701 ttcctgttta ttatctagca cataacgcaa gatggtctta tcaagatctc ctaaggcctt
     8761 ttgatgtttt gtgatcaatt cttctagtgt cat
//
