LOCUS       c00004_NZ_AQXB..       10303 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AQXB01000004.1 Corynebacterium mastitidis DSM 44356
            B140DRAFT_scaffold_3.4_C, whole genome shotgun sequence.
ACCESSION   NZ_AQXB01000004
VERSION     NZ_AQXB01000004
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:15:02
            Original ID  :: NZ_AQXB01000004.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 103407
            Orig. end    :: 113710
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10303
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[108407:108710](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5303)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10303
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10303
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             471..1412
                     /gene_functions="transport (smcogs) SMCOG1033:iron compound
                     ABC transporter, periplasmic (Score: 198.6; E-value:
                     1.9e-60)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_112"
                     /transl_table=11
                     /translation="MTYTYRSPLTRRGFLGASLLSAAGVAGAALAACSSSDPEPADLAR
                     RVAPSRVVALNTGQLETLLVLGIVPVGIATASSDATAAPGVPDFVQEEFGQSHNLDGIE
                     IVGERSDPSLEKIAALEPDLILANQRADSGLLDRLRALAPVVLSNGGSEKWKEDLGIVA
                     EAVGQREAAQRMLARYEEDARVWAQQRGDEATVSLVRSKGRQYVIHGEHSLAGIVARDA
                     GFTRPESQTFTDQPNKEISPENFHELEADYLFYSFGGPAADVLDDPLWTGLDAVTQGRA
                     HEVDGDPWFLNASIVSARRVLADMKRAVAARQ"
     aSDomain        495..563
                     /aSDomain="TIGR01409"
                     /aSTool="tigrfam"
                     /description="TAT_signal_seq: Tat (twin-arginine
                     translocation) pathway signal sequence"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg4_112_0001"
                     /evalue="5.00E-04"
                     /identifier="TIGR01409"
                     /label="ctg4_112"
                     /locus_tag="ctg4_112"
                     /protein_end="31"
                     /protein_start="8"
                     /score="18.3"
                     /tool="antismash"
                     /translation="LTRRGFLGASLLSAAGVAGAALA"
     PFAM_domain     624..1325
                     /aSDomain="Peripla_BP_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01497.20"
                     /description="Periplasmic binding protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_112_0001"
                     /evalue="4.50E-23"
                     /label="ctg4_112"
                     /locus_tag="ctg4_112"
                     /protein_end="285"
                     /protein_start="51"
                     /score="82.0"
                     /tool="antismash"
                     /translation="VVALNTGQLETLLVLGIVPVGIATASSDATAAPGVPDFVQEEFGQ
                     SHNLDGIEIVGERSDPSLEKIAALEPDLILANQRADSGLLDRLRALAPVVLSNGGSEKW
                     KEDLGIVAEAVGQREAAQRMLARYEEDARVWAQQRGDEATVSLVRSKGRQYVIHGEHSL
                     AGIVARDAGFTRPESQTFTDQPNKEISPENFHELEADYLFYSFGGPAADVLDDPLWTGL
                     DAVTQGRAHEVD"
     CDS             1424..2320
                     /locus_tag="ctg4_113"
                     /transl_table=11
                     /translation="MSTTQHPAAPPCSEAAAEPLEGTAKRAEAYVLFEWPGGWSRDVLD
                     GGTFGPDLSARLKKALKGRASLQLIRRPGRAGRDVGARHRCYLVWARAGAMELLLLDGP
                     EDLLRLDLSGPGRNGGQRVDTPLLLVCTHGRRDVCCAVKGRPLAAELARDFPEQAWETS
                     HTKGHRFAPAVLLMPWGYSFGRLNAPAARELLTRALRGGFFLPANRGSGLYGPRGQVAE
                     LRVARALLDAGEDLAYGDLSADDAPEGPVAVRHRDGRRWEVPLVRREVEGVVASCGGAP
                     KTVKAWVAESGIHEEPA"
     PFAM_domain     1790..2023
                     /aSDomain="Suc_Fer-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06999.14"
                     /description="Sucrase/ferredoxin-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_113_0002"
                     /evalue="2.30E-14"
                     /label="ctg4_113"
                     /locus_tag="ctg4_113"
                     /protein_end="200"
                     /protein_start="122"
                     /score="53.8"
                     /tool="antismash"
                     /translation="VDTPLLLVCTHGRRDVCCAVKGRPLAAELARDFPEQAWETSHTKG
                     HRFAPAVLLMPWGYSFGRLNAPAARELLTRALR"
     CDS             complement(2294..2938)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 188.5; E-value:
                     2.4e-57)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_114"
                     /transl_table=11
                     /translation="LSPTITVSRLTKAFGRRTLWRDVEFSCPRGSITALTGPSGSGKST
                     LLNCIGTLDTADSGTITAAGRNIQELSSGKRRRFRKNNLGFLFQDYALIPDKTVEYNLR
                     LATVNKQQRARIDSALDTVGLEGYRKRMVHELSGGEQQRVALARILARQPEIILADEPT
                     GALDPANGHNVVRQLRDLADQGATVVIATHAADVRDAADQHVDLSRFLVDA"
     PFAM_domain     complement(2450..2878)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_114_0003"
                     /evalue="1.80E-35"
                     /label="ctg4_114"
                     /locus_tag="ctg4_114"
                     /protein_end="163"
                     /protein_start="20"
                     /score="122.5"
                     /tool="antismash"
                     /translation="RDVEFSCPRGSITALTGPSGSGKSTLLNCIGTLDTADSGTITAAG
                     RNIQELSSGKRRRFRKNNLGFLFQDYALIPDKTVEYNLRLATVNKQQRARIDSALDTVG
                     LEGYRKRMVHELSGGEQQRVALARILARQPEIILADEPT"
     misc_feature    complement(2726..2728)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(2951..3997)
                     /locus_tag="ctg4_115"
                     /transl_table=11
                     /translation="MILEIQHQKSQQHIWNSHSEAVAFQISTRTGDTNGDVAPALRAAD
                     ERGELLLCLVSEDLSRSPNTLVVNSLFAEQELSLPASETPQPGEALILVPEGAPAEHVA
                     SAREKVLYEAEYAGIPAPHVTEKPIPGDTEVFTYASSFGFTLPEATVSGVPIVVLPRGL
                     ETLADRNLVAPATQLQLFAANGEAMQKIMSDPSAGPYIAGHFTALSHWEEAHAKAQSQF
                     RFQSINLGILVLVVTAYVLGSAAVYQTRHRQRLTVTDLMGGSPWKARLGLLAIEAAFLL
                     VPAAWLLHRHRAYEEAALTAMPRDVLRSMAVTPELVAATIGISAIWALTCLAMSAHLGR
                     IYSRTPAR"
     CDS             complement(5001..5303)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_116"
                     /sec_met_domain="Lactococcin_972 (E-value: 9e-17, bitscore:
                     55.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFLRKKITRGLAATALSGALVAGGAAAALATQVNVDGGTWNYGVE
                     GGKVWSNYYHGARSHGSSVQGKHYADSGCVGADQWSYASAPDRFGRADHSYYRFC"
     aSDomain        complement(5007..5291)
                     /aSDomain="TIGR01653"
                     /aSTool="tigrfam"
                     /description="lactococcin_972: bacteriocin, lactococcin 972
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg4_116_0002"
                     /evalue="1.20E-12"
                     /identifier="TIGR01653"
                     /label="ctg4_116"
                     /locus_tag="ctg4_116"
                     /protein_end="99"
                     /protein_start="4"
                     /score="45.9"
                     /tool="antismash"
                     /translation="KKITRGLAATALSGALVAGGAAAALATQVNVDGGTWNYGVEGGKV
                     WSNYYHGARSHGSSVQGKHYADSGCVGADQWSYASAPDRFGRADHSYYRF"
     PFAM_domain     complement(5013..5198)
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_116_0004"
                     /evalue="5.90E-15"
                     /label="ctg4_116"
                     /locus_tag="ctg4_116"
                     /protein_end="97"
                     /protein_start="35"
                     /score="55.6"
                     /tool="antismash"
                     /translation="DGGTWNYGVEGGKVWSNYYHGARSHGSSVQGKHYADSGCVGADQW
                     SYASAPDRFGRADHSYY"
     CDS             complement(5531..6208)
                     /gene_functions="transport (smcogs) SMCOG1044:ABC
                     transporter, permease protein (Score: 63.4; E-value:
                     3.1e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_117"
                     /transl_table=11
                     /translation="MTTTVLAADWDRLGDTFREAIADTLIMVSITMIVSGLLGLLVGIL
                     LYTTRSGGILKNSVVYTVLNVLVNFVRPIPFIILIAALQPVTVAAMGTSVGRDAGIFVM
                     IIAATFTVARIVEQNLVAIDPGMIEAARAMGASPWKIITSVIVPEALGPLVLGYTFIFI
                     AIVDMSAMVGYIGGGGLGDFAIVYGYRAFDKEAMYVAVIAIVILVQAAQFLGNWLSKKI
                     MRR"
     PFAM_domain     complement(5543..6091)
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00528.24"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_117_0005"
                     /evalue="6.30E-16"
                     /label="ctg4_117"
                     /locus_tag="ctg4_117"
                     /protein_end="222"
                     /protein_start="39"
                     /score="58.7"
                     /tool="antismash"
                     /translation="LLVGILLYTTRSGGILKNSVVYTVLNVLVNFVRPIPFIILIAALQ
                     PVTVAAMGTSVGRDAGIFVMIIAATFTVARIVEQNLVAIDPGMIEAARAMGASPWKIIT
                     SVIVPEALGPLVLGYTFIFIAIVDMSAMVGYIGGGGLGDFAIVYGYRAFDKEAMYVAVI
                     AIVILVQAAQFLGNWLSKKI"
     CDS             complement(6205..7263)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 245.2; E-value:
                     1.1e-74)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_118"
                     /transl_table=11
                     /translation="MAPKAQSPTAGTRIEFRETTKVFPAKSRNQAADTTAVDGVTLTVE
                     PGEILGVIGYSGAGKSTLVRLINGLDQATSGQLLLDGTDVVGMSERQLRGVRSKIGMIF
                     QQFNLFSSRTAAGNIEYPLKLAGVPKEERKRRVEELLSFVGLADKGGNYPEQLSGGQKQ
                     RVGIARALATNPSLLLADEATSALDPETTHDVLELLRRVNKELGITIVVITHEMEVVRS
                     IADKVAVMEGGRVVEYGSVYEVFSQPRTAVSARFVATSLRNTPDNVETEDLLAHEGRLF
                     TIELTEESGFFAAAAAARSAGVRIAIVHGGVTTLQQHSFGKMTVRLSGPQDAINTFRDA
                     LAQTTTIQEITR"
     PFAM_domain     complement(6235..6378)
                     /aSDomain="NIL"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09383.12"
                     /description="NIL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_118_0007"
                     /evalue="3.40E-08"
                     /label="ctg4_118"
                     /locus_tag="ctg4_118"
                     /protein_end="343"
                     /protein_start="295"
                     /score="33.4"
                     /tool="antismash"
                     /translation="AAARSAGVRIAIVHGGVTTLQQHSFGKMTVRLSGPQDAINTFRDA
                     LAQ"
     PFAM_domain     complement(6709..7152)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_118_0006"
                     /evalue="2.90E-34"
                     /label="ctg4_118"
                     /locus_tag="ctg4_118"
                     /protein_end="185"
                     /protein_start="37"
                     /score="118.6"
                     /tool="antismash"
                     /translation="DGVTLTVEPGEILGVIGYSGAGKSTLVRLINGLDQATSGQLLLDG
                     TDVVGMSERQLRGVRSKIGMIFQQFNLFSSRTAAGNIEYPLKLAGVPKEERKRRVEELL
                     SFVGLADKGGNYPEQLSGGQKQRVGIARALATNPSLLLADEATS"
     CDS             complement(7294..8154)
                     /locus_tag="ctg4_119"
                     /transl_table=11
                     /translation="MKLRRIIATGVVAALATTGLAACSNSDAIRIGTTDSARGAWQVFE
                     DKAAEAGIKLKTTEFGDYSTPNDALAQGELDVNLFQHLKFLANYNVGADKDLTPVGSTE
                     IVPLALFWKDHSSLDGIEGQSIAIPNDVVNQGRAINVLVQANLLTLKSKDLLDPTPADI
                     DEAASKVSVTPVDAAQTSVTYGEGRPSIINNNFLDRAGIDPNTAVTQDDPNNKLAEPYI
                     NVFVTKAEDKDNEDIAKLVEIWHSPEVQAAVAEDSKGTSVSVNRPAEELQGILENIEAN
                     QRDAK"
     PFAM_domain     complement(7369..8070)
                     /aSDomain="Lipoprotein_9"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03180.16"
                     /description="NlpA lipoprotein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_119_0008"
                     /evalue="6.30E-56"
                     /label="ctg4_119"
                     /locus_tag="ctg4_119"
                     /protein_end="262"
                     /protein_start="28"
                     /score="189.3"
                     /tool="antismash"
                     /translation="IRIGTTDSARGAWQVFEDKAAEAGIKLKTTEFGDYSTPNDALAQG
                     ELDVNLFQHLKFLANYNVGADKDLTPVGSTEIVPLALFWKDHSSLDGIEGQSIAIPNDV
                     VNQGRAINVLVQANLLTLKSKDLLDPTPADIDEAASKVSVTPVDAAQTSVTYGEGRPSI
                     INNNFLDRAGIDPNTAVTQDDPNNKLAEPYINVFVTKAEDKDNEDIAKLVEIWHSPEVQ
                     AAVAEDSKGTSV"
     CDS             complement(8301..8774)
                     /locus_tag="ctg4_120"
                     /transl_table=11
                     /translation="MSAPFHVIFDNPVIPGNTGNAIRLCANTGAHLHLVEPLGFNFDDK
                     HLKRAGLDYHDLAEVSIHPDLDACLATLPGARVFAFTAASPTWHTSVEYRPGDALLFGT
                     EPTGLPEEHLRHPRITQRVRIPMLPARRSMNLSNSAAVAVFEAWRQGGFPGAA"
     PFAM_domain     complement(8343..8762)
                     /aSDomain="SpoU_methylase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00588.21"
                     /description="SpoU rRNA Methylase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_120_0009"
                     /evalue="7.60E-31"
                     /label="ctg4_120"
                     /locus_tag="ctg4_120"
                     /protein_end="144"
                     /protein_start="4"
                     /score="107.3"
                     /tool="antismash"
                     /translation="FHVIFDNPVIPGNTGNAIRLCANTGAHLHLVEPLGFNFDDKHLKR
                     AGLDYHDLAEVSIHPDLDACLATLPGARVFAFTAASPTWHTSVEYRPGDALLFGTEPTG
                     LPEEHLRHPRITQRVRIPMLPARRSMNLSNSAAVAV"
     CDS             8800..9666
                     /locus_tag="ctg4_121"
                     /transl_table=11
                     /translation="MGAVTAIKLDGKLYRSELVEDLRQRVAALRARGITPGLATVLVGE
                     DPGSQNYVRMKHKDCEEVGITSIRRDLPETTPQEELEAVIDELNNDPACTGYIVQLPLP
                     RHLDENAILGRIDPDKDADGLHPVNLGKLVLNEPAPLPCTPHGSIQLLRRFGVELDGAK
                     VVVIGRGVTVGRPIGLMLTRRSENATVTLCHTGTKDLAAETREADVIIAAAGQPHMLTA
                     DMIKPGAALLDVGVSRVDGKTTGDVHPDCWEVAGAISPNPGGVGPMTRTFLMANIVERA
                     ERLADGS"
     PFAM_domain     8824..9168
                     /aSDomain="THF_DHG_CYH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00763.25"
                     /description="Tetrahydrofolate
                     dehydrogenase/cyclohydrolase, catalytic domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_121_0010"
                     /evalue="5.10E-37"
                     /label="ctg4_121"
                     /locus_tag="ctg4_121"
                     /protein_end="123"
                     /protein_start="8"
                     /score="126.7"
                     /tool="antismash"
                     /translation="LDGKLYRSELVEDLRQRVAALRARGITPGLATVLVGEDPGSQNYV
                     RMKHKDCEEVGITSIRRDLPETTPQEELEAVIDELNNDPACTGYIVQLPLPRHLDENAI
                     LGRIDPDKDAD"
     PFAM_domain     9175..9648
                     /aSDomain="THF_DHG_CYH_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02882.21"
                     /description="Tetrahydrofolate
                     dehydrogenase/cyclohydrolase, NAD(P)-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_121_0011"
                     /evalue="5.90E-59"
                     /label="ctg4_121"
                     /locus_tag="ctg4_121"
                     /protein_end="283"
                     /protein_start="125"
                     /score="198.1"
                     /tool="antismash"
                     /translation="HPVNLGKLVLNEPAPLPCTPHGSIQLLRRFGVELDGAKVVVIGRG
                     VTVGRPIGLMLTRRSENATVTLCHTGTKDLAAETREADVIIAAAGQPHMLTADMIKPGA
                     ALLDVGVSRVDGKTTGDVHPDCWEVAGAISPNPGGVGPMTRTFLMANIVERAER"
     CDS             9656..9982
                     /locus_tag="ctg4_122"
                     /transl_table=11
                     /translation="MAPNSYLDNPHDVALPPSRLPVWAQRAMMGAFLLVLAVSALCAFT
                     EHWRRATFGLGAAMIWLGVVRLLCDSRVVGIFAVRSRRFDVFFSALLGGVMSFLAASVD
                     ALGS"
     PFAM_domain     9746..9961
                     /aSDomain="DUF3017"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11222.10"
                     /description="Protein of unknown function (DUF3017)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_122_0012"
                     /evalue="1.30E-21"
                     /label="ctg4_122"
                     /locus_tag="ctg4_122"
                     /protein_end="102"
                     /protein_start="30"
                     /score="76.8"
                     /tool="antismash"
                     /translation="AFLLVLAVSALCAFTEHWRRATFGLGAAMIWLGVVRLLCDSRVVG
                     IFAVRSRRFDVFFSALLGGVMSFLAAS"
ORIGIN
        1 gcggcgcctg cggcgtcgcg gctacctgcc gtgggcggcc gctgcggtgc tgatctggca
       61 gctcggcctg gcgccggcct acggcggcag gggagtgctc gtgaccgccg tggcctgggg
      121 cttcgtgtgc gcggcggcgt accgggccgc ggacttcggg cgcctggggg tggcctcgcc
      181 cgcgcgctgg ggctacctcg tggcttgcgc ggtggccggg gccgtggtgc tcgccgcgca
      241 ggggcgcggc gcggcggagg tggccgccgt ggcgctggtg tgggtgttcg tggggcgcag
      301 gcgcggcagg ccgaacaggg tgcggagcac ctccttcttc gactccggca tgggcgtgag
      361 cttctcgccc gaggtggtgc ggtactacgc gcgggggctg ctacccatcc tgcccctggg
      421 gctcctccta tattaggtat gccttgccat attgatatat ggtatagttt atgacttata
      481 cgtatcgctc ccccctcact cgccggggat tcctcggcgc gagtctcctc agtgctgcgg
      541 gcgttgcggg cgcagcgctc gcggcctgct cgtccagcga tccggaaccc gcagacctcg
      601 cccgccgcgt ggcgccgagc cgagtggtgg cgctcaatac cgggcagctc gagaccctgc
      661 tggttctggg gatcgtgccc gtgggcatcg ccaccgcctc ctccgacgcc accgcggctc
      721 cgggagttcc ggactttgtg caggaggagt tcgggcagag ccacaacctc gacggcatcg
      781 agatcgtggg cgagcgctct gatccttcgc tggaaaagat cgccgccctc gagccggacc
      841 tcatcctggc caaccagcgc gccgactccg ggctgctgga tcgcctgcgc gcgctggccc
      901 ccgtggtgct cagcaacggg ggatcggaaa agtggaagga ggacctcggg atcgtcgcgg
      961 aggccgtggg ccagcgcgag gccgcgcagc gcatgctcgc gcgctacgag gaggacgcgc
     1021 gggtgtgggc gcagcagcgc ggcgacgagg ccaccgtgtc cctggtgcgc agcaagggtc
     1081 ggcagtacgt gatccacggc gagcactccc tggccgggat cgtggcgcgg gacgccggat
     1141 tcacgcgccc cgaatcgcag acctttaccg atcagcccaa caaggagatc tcgccggaga
     1201 atttccacga gctggaggcc gactacctct tttactcctt cggcggaccc gcggcggacg
     1261 tcctggacga ccccctgtgg accggtctgg acgcggtgac ccagggccgc gcgcacgagg
     1321 tggacggcga cccctggttc ctcaacgcct ccattgtctc cgcgcgccgg gtcctggcgg
     1381 acatgaagag ggccgtggcc gcccggcagt aggataccgg ggcatgagta ccacccagca
     1441 cccagccgcc ccgccctgct ccgaggcggc agccgagccc ctggagggaa ccgccaagcg
     1501 ggccgaggcg tacgtgctct tcgagtggcc cggaggatgg tcccgcgacg tgctcgacgg
     1561 cggcaccttc ggccccgacc tgagcgcgcg gctcaagaag gccctcaagg gcagggccag
     1621 cctccagctc atccgacgcc ccggccgcgc gggccgggac gtgggcgcgc gccaccgctg
     1681 ctacctggtg tgggcgcgcg ccggggcgat ggagctgctg cttctcgacg gccccgagga
     1741 cctcctgcgc ctggacctct ccggccccgg ccgcaacggg ggccagcgcg tggacacccc
     1801 gctgctgctg gtatgcaccc acgggcgcag ggacgtatgc tgcgcggtca aggggcgccc
     1861 cctcgccgcc gagctcgccc gagacttccc cgagcaggca tgggagacct cgcacaccaa
     1921 gggccaccgc ttcgcccccg ccgtgctgct catgccctgg ggctactcct tcggccgcct
     1981 caacgccccg gccgcgcggg aactcctgac ccgggcgctg cgcgggggct tcttcctccc
     2041 cgccaaccgg ggcagcgggc tctacgggcc gcgcggccag gtggccgagc tgcgggtggc
     2101 ccgcgcgctc ctggacgccg gggaggacct cgcctacggc gacctcagcg cggacgacgc
     2161 cccggagggt cccgtcgccg tgcggcaccg tgacggccgc cgctgggagg ttcccctggt
     2221 gcgccgcgag gtcgaggggg tggtggcctc ctgcggcggc gcgcccaaga cggtcaaggc
     2281 gtgggtggcg gagtcaggca tccacgagga accggcttag gtcaacgtgc tggtcggcgg
     2341 cgtcgcggac atcggcggca tgggtggcga tgaccaccgt ggccccctga tccgcgagat
     2401 cgcggagctg ccgcactacg ttgtggccgt tggcggggtc cagcgcgccc gtgggctcgt
     2461 ccgcgaggat gatctccggc tggcgggcca ggatgcgggc cagcgccacg cgctgctgct
     2521 cgccgccgga gagctcgtgg accatgcgct tgcggtatcc ctccaggccc acggtatcga
     2581 gcgcggagtc gatccgagcg cgctgctgct tgttgacggt ggccaggcgc aggttgtact
     2641 ccacggtttt atccgggatc agggcgtaat cctggaagag gaaacccagg ttgttcttgc
     2701 ggaacctccg gcgcttgccg ctggataact cctggatgtt cctccctgcc gccgtgatgg
     2761 tgccggaatc ggcggtatcg agggtgccga tgcagttgag cagcgtggac tttccgctgc
     2821 cggagggccc ggtgagggcg gtgatgctgc cgcgcgggca ggaaaactcc acatcgcgcc
     2881 acagggtgcg gcgcccgaag gccttggtga ggcgggagac ggtgatcgtg ggggacaagg
     2941 gtggttctcc ttagcgtgcg ggggtgcggg agtagatgcg gccgaggtgg gcggacatgg
     3001 cgaggcaggt aagcgcccag atcgcggata tgcctatcgt ggcggcgacg agttccgggg
     3061 tgacggccat ggaacgcaga acgtcgcggg gcatagccgt gagcgcggcc tcctcgtagg
     3121 cgcggtggcg gtgtagcagc cacgcggcgg gaacgaggag gaaggccgcc tcgatcgcca
     3181 gcaggccgag ccgtgccttc cagggggagc cgcccatgag gtccgtgacg gtgaggcgct
     3241 gccggtgccg ggtctggtac acggcggcgg agcccagcac gtaggcggtg accacgagga
     3301 cgaggatacc caggttgatg gattggaagc ggaattggct ctgcgccttg gcgtgggcct
     3361 cctcccagtg cgatagcgcg gtgaaatgcc cggcgatgta ggggcccgcc gaggggtcag
     3421 acatgatttt ttgcatcgcc tcgccgttgg cggcgaatag ctgcaactgc gtggcgggag
     3481 ccacgagatt gcggtccgcc agcgtctcta gtccgcgagg cagtaccacg atggggaccc
     3541 cgctcaccgt ggcctcgggg agggtaaaac cgaaggagga cgcgtaggtg aacacctcgg
     3601 tatcgccggg aatgggcttc tccgtgacgt gtggtgccgg aattccggcg tattccgcct
     3661 cgtaaagcac cttctcacga gcgctagcga cgtgctcggc gggggcgccc tcggggacca
     3721 ggatgagtgc ctcgcccggc tgcggggttt cgctggcggg caaggagagc tcctgctcgg
     3781 caaacagaga attaacgacg agagtgttgg ggctgcgcga aagatcctcc gagaccaggc
     3841 agagcagaag ctcgcctctc tcgtcggcgg cgcgcagcgc gggggcgacg tcgccattag
     3901 tatcccccgt gcgggtggaa atctggaacg ccaccgcctc actgtgagag ttccaaatat
     3961 gttgctgcga tttttggtgt tgtatttcta ggatcatcga tactgttgcg cctactgtga
     4021 tgagggcggc tgtgagggcg cagaagcgga gaacgtacgt tccgaaagaa acggaatttc
     4081 ccggaatctt gccatttaat gcgggaatga ggtcggttag atggagtgtg gctacgccga
     4141 tgatgaggct gaggagaagt gtggtaccac cggcaatgag gagaccgcca gtgcagcgcg
     4201 cgtagagtcc tgtggcgttg aagccgttat agaggtagag tgccagggcg ctgagtgttc
     4261 cgcagataat aaaggaaaga agtgtggagg gaaggagtgc gcgtatatcg ctgccgatga
     4321 tcttccagaa tccgtgtcca tggatacgcc gaatcgcgta atcgcgtgca cgtaatagaa
     4381 ctccacccaa ggttatggtg gtgatgagaa gtagcatagc tgcgatagta attgtggtgg
     4441 ggttgctgag aatataatcc caattaacgt cataattttt tacggtaaaa cctagtgacg
     4501 tgatatattg ctggagatcg tttttttcat cggctgttcc agcgacatgg tatacgcctc
     4561 cggcgtcggt cagttccgcc tcagatagga ggcttacgga cacgtttact gaagggtcaa
     4621 aacccgagta gccggtacgg agccacgtgc tcatggtgga ggagtcttcc ccaggggaaa
     4681 cgtagagatg atgggtggtt ccttcgtttg tggcttcaaa atgctcaagg cctacggtga
     4741 tgtggttttc cttggtatag cgtgtgatat tttcttggag ttgggtgggg gaggtctctc
     4801 cagaagattc tgtgatgaga aatgactgtc tgccagcgga ggcgaggtca ctgtctaaga
     4861 ggtgggtgag gggaaacgcg acaaggaaac ttaaaatcag tagtaaagag ctggatattc
     4921 gtaataggtg gtgcatggga tattctccta gtggaaaatg cctcacccat ggggagtgga
     4981 tgaggcaaag aaagaaggaa ctagcagaag cggtagtagg agtgatcggc cctaccgaag
     5041 cggtcgggtg ccgatgcgta agaccactga tcggctccca cgcagccgct atcggcgtag
     5101 tgctttcctt gtacgctgga gccgtgactg cgggctccgt ggtagtaatt ggaccaaacc
     5161 ttgcctcctt cgacgccgta gttccaggtg ccgccatcaa cgttgacctg ggtggccagc
     5221 gcggcagccg ccccgcccgc gaccagggcg ccggacagcg ccgtggcggc caggccgcgc
     5281 gtgatcttct tgcgcaagaa catgagatgc ctcctcgaag cactagggaa taggatgcga
     5341 gtctgtagtg gcgatcgact ctgatttaca tatcacaccg taaaattaac ctgtgagttt
     5401 catgtgagag aacctagaat gaacaaacag gaaattctcc tctaacatcc aagaaggcct
     5461 gcccaaacac acataaggcc ccgccccctc acggaaaggg gcggggccag cggcgggccg
     5521 gtaggaggcc ctagcgccgc atgatcttct tggagagcca gttgccgagg aactgcgcgg
     5581 cctgaaccag gatcacgatg gcgatcacgg ccacgtacat ggcctcctta tcaaaggccc
     5641 ggtagccgta cacgatggcg aagtcgccca ggccgccgcc gccgatgtag ccgaccatgg
     5701 ctgacatgtc cacgatggcg atgaagatga aggtgtagcc cagcaccagc ggtccgagcg
     5761 cctcggggac gatcaccgag gtgatgatct tccaggggct ggcgcccatg gcgcgggcgg
     5821 cctcgatcat gccggggtcg atggccacga ggttttgctc cacgatgcgc gccacggtga
     5881 aggtggcggc gatgatcatc acgaagatgc cggcgtcgcg gcccaccgag gtgcccatgg
     5941 cggccaccgt gacgggctgg agcgcggcga tgaggatgat gaaggggatg gggcgaacga
     6001 agttcaccag cacgttgagc accgtgtaca ccacggagtt cttgaggatt ccgccggagc
     6061 gggtggtgta gagcaggatg cccacgagga ggccgagcag cccggagacg atcatggtga
     6121 tcgagaccat gatgagggtg tccgcgatgg cctcgcggaa ggtatcgccg aggcgatccc
     6181 agtctgcggc aaggacggta gtggtcatcg ggtgatctcc tggatggtgg tggtctgagc
     6241 caaggcgtcg cggaaggtgt tgatcgcgtc ctggggcccg ctgagtcgca cggtcatctt
     6301 gccaaagctg tgctgttgca gggtggtcac gccgccgtgg acgatggcga tgcgcacccc
     6361 ggcgctgcgg gcggctgccg cggcggcgaa gaagccggac tcctcggtca gctcgatggt
     6421 gaacaggcgg ccctcgtggg cgagcaggtc ctccgtctcc acgttgtccg gggtgttgcg
     6481 cagcgaggtc gccacgaagc gcgcggacac ggccgtgcgg ggctgcgaga acacctcgta
     6541 cacgctgccg tactccacca cgcggccgcc ctccatcacg gccaccttgt ccgcgatgga
     6601 gcgcaccacc tccatctcgt gcgtgatcac cacgatggtg atgcccagct ccttgttcac
     6661 ccggcgcagc agctccagca cgtcgtgggt ggtctccggg tcgagggcgg aggtggcttc
     6721 gtcggcaagc agcagggagg ggttggtggc cagcgcgcgg gcgatgccca cccgctgctt
     6781 ctgcccgccg gagagctgct cggggtagtt gccgccctta tctgccaggc ccacgaagct
     6841 cagcagctcc tccacgcggc gcttgcgctc ctccttgggc acgccggcga gcttgagcgg
     6901 gtactcgatg ttgccggcgg cggtgcggga gctaaacagg ttgaactgct ggaagatcat
     6961 cccgatcttg ctgcgcacgc cgcgtagctg ccgctcggac atgcccacga cgtcggtgcc
     7021 gtcgagaagc aactgcccgg aggtggcctg atcgagcccg ttgatgaggc gaaccagggt
     7081 ggactttccg gcgccggagt acccgatcac gccgaggatc tcgcctggtt ccacggtgag
     7141 ggtgacgccg tccacggcgg tggtgtcggc cgcctggttg cgggacttgg cggggaatac
     7201 cttggtggtc tcgcggaact cgatgcgggt tccggcggtg ggggactgag ccttgggggc
     7261 catgagggga atacctttaa tcctgggtca gggttacttc gcgtcgcgct ggttggcctc
     7321 gatgttctcc aggatgccct ggagctcctc ggcggggcgg ttcacggaca cggaggtgcc
     7381 cttggaatcc tccgccacgg cggcctgcac ctcgggggag tgccagatct ccaccagctt
     7441 ggcgatgtcc tcgttgtcct tatcttctgc cttggtgaca aagacgttga tgtagggctc
     7501 cgccagcttg ttattggggt cgtcctgggt cacggcggtg ttggggtcga tgcccgcgcg
     7561 gtccaggaag ttgttgttga tgatggaggg gcggccctcg ccgtaggtca ccgaggtctg
     7621 ggcggcgtcc acgggggtaa cggagacctt ggaggcggcc tcgtcgatgt ccgccggggt
     7681 ggggtcgagc aggtccttgg acttcagggt gagcaggttg gcctgcacca gcacgttgat
     7741 ggcgcggccc tggttgacca cgtcgttggg aatggcgatg gactggccct cgatgccgtc
     7801 cagggaggag tgatccttcc agaacagcgc cagcggcacg atctccgtgg agcccaccgg
     7861 ggtgaggtcc ttgtctgcgc ccacgttgta gttggccagg aacttcaggt gctggaagag
     7921 gttgacgtcc agctcgccct gggccagggc gtcgttcggc gtgctgtagt cgccaaactc
     7981 ggtggtcttg agcttgatcc cggcctcggc ggccttgtcc tcaaagacct gccaggcgcc
     8041 ccgggcggag tcggtggtgc cgatgcggat ggcgtcggag ttcgagcagg ctgccaggcc
     8101 cgtggtggca agagcggcaa caactccggt ggcgatgatg cggcgaagct tcatgaggcg
     8161 aggtcctttc cccgtgttcc tacgaatgtc tcactgcacg atagcagcca ccgaaccgct
     8221 tagtctatta agggggattc gcacggtctg ggcgcgcggg gtggggcctt ctcagcggcg
     8281 ctgccccgcg ccgccggggc ctacgcggcc ccggggaacc cgccctgccg ccacgcctcg
     8341 aacaccgcca cggcggcgga gttggagagg ttcatcgagc gccgcgcggg cagcatggga
     8401 atgcgcacgc gctgcgtgat ccgggggtgg cggagatgct cctccggcag gccggtgggc
     8461 tcggtgccga acagcagggc gtcgcccggc cggtactcca cggaggtgtg ccaggtgggc
     8521 gaggcggcgg tgaaggcgaa cacgcgggcg cccggcagcg tggcgaggca ggcgtccagg
     8581 tcggggtgga tgctcacctc cgcgaggtcg tggtagtcca ggcccgcgcg cttgaggtgc
     8641 ttgtcgtcga agttgaagcc cagcggctcc accaggtgca ggtgcgcccc ggtgttggcg
     8701 cacaggcgga tggcgttgcc ggtgttgccg gggatcaccg ggttatcaaa gatcacgtga
     8761 aagggcgcgg acatggccct cattctaggg ggaggcataa tgggtgccgt gactgcgatc
     8821 aaactcgatg gaaagctcta ccgctccgaa ctggtggagg acctgcgcca gcgcgtggcc
     8881 gccctgcgcg ccagggggat cacccccggg ctggccaccg tgctggtggg cgaggacccc
     8941 ggaagccaga actacgtgcg catgaagcac aaggactgcg aggaggtggg gatcacctcc
     9001 atccgccgcg acctgccgga gaccaccccc caggaggagc tggaggcggt gatcgacgag
     9061 ctgaataacg atcccgcctg caccggctac attgtgcagc tccccctgcc ccggcacctg
     9121 gacgagaacg ccatcctggg gcgcatcgac ccggacaagg acgccgacgg cctccacccc
     9181 gtgaacctgg gcaagctcgt gctcaatgag cccgcgcccc tgccctgcac cccccacggc
     9241 tccattcagt tgctgcgccg ctttggcgtg gagcttgacg gcgccaaggt ggtggtgatc
     9301 gggcgcggcg tgaccgtggg ccgccccatc gggctcatgc tcacccgccg ctccgagaac
     9361 gccaccgtga ccctctgcca caccggaacc aaggacctgg cggcggagac ccgcgaggcg
     9421 gacgtgatca tcgccgccgc cgggcagccc cacatgctca ccgcggacat gattaagccg
     9481 ggcgcggcgc tgctggacgt gggcgtgtcc cgcgtggacg gcaagaccac cggcgacgtc
     9541 cacccggact gctgggaggt cgccggggcg atctccccca accccggcgg cgtggggccg
     9601 atgacccgca ccttcctcat ggccaacatc gtggagcggg cagagcgcct ggccgatggc
     9661 tcctaactcc tacctggaca acccccacga cgtggccctg ccgccctccc ggttgccggt
     9721 ctgggcgcag cgggccatga tgggggcgtt cctcctggtg ctcgccgtca gcgccctgtg
     9781 cgccttcacg gagcactggc ggcgcgccac cttcggtctg ggcgcggcga tgatctggct
     9841 gggggtggtg cgcctgctgt gcgactcccg cgtggtgggc atcttcgccg tgcgttcccg
     9901 gcgcttcgac gtcttcttta gcgccctgct cggcggcgtg atgagctttc tggcggcctc
     9961 cgtggacgcg ctggggagct aagcgcggga gctagacagg ggagctaagc ggggggctag
    10021 acggggagcg atgccgcgct gccgggctcc ccggctcgcg gcgcatcgcc cgggacgcgc
    10081 cccaggaagt cccggatgat ccggtccatc tgccgcgtct ccgccaggaa ggcgtcgtgc
    10141 cccaccgggg agacgatctt ggccatgccc agcaggttgc ccaggttgcg cgagaggtgt
    10201 tcctgctggt ggtaggggta gaggatgtcc gtgtccaccc cggccacgaa ggtcggggtg
    10261 gtaatggccg ccagcgcctt gttcagcccg ccgcgccccc ggc
//
