LOCUS       NC_022112.1            10255 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_022112.1 Lacticaseibacillus paracasei subsp. paracasei 8700:2,
            complete sequence.
ACCESSION   NC_022112
VERSION     NC_022112.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:37:15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2700225
            Orig. end    :: 2710480
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10255
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2705225:2705480](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5255)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10255
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10255
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(3..629)
                     /locus_tag="ctg1_2588"
                     /transl_table=11
                     /translation="MKKTKTKLLTLCGVLAIGASLLGSTQVYAYENGQNDPHAATNTLE
                     VKKTDSATISAEGTFEPFDPTKLPDPAKPTPKKDHKAWVDVKIPSKVLFSQTDVSEGII
                     SPNYEIQNLSAKGVKVSINDFTDGDNANKLEGRLDLNLNSDGKKIALRSTDKQKVPSFP
                     TEIGTITSQNGKIQFTLAGSVKKGFDFTKETVKANYKLVLKFEVQ"
     CDS             complement(672..1184)
                     /locus_tag="ctg1_2589"
                     /transl_table=11
                     /translation="MQKNKKLKLVVLLLLLVGIVSIGSYMYLHRSVPNVVANGGGAEDT
                     SFVKNMTDEELKEYLQEKADKSKFHLKLDTNMVFNAANEVGTVNILNPASNQYGIRVQT
                     RLEGQNKVIYDSGLIKPKQYVEAGELKANLKRGVYKTQSTVTYYELADSSTKIGETAIV
                     GQLSVNN"
     CDS             1340..2827
                     /locus_tag="ctg1_2590"
                     /transl_table=11
                     /translation="MEELLESNLLRHFRIVRFLLGREWVTIGELAHTLRIPSRTIRQSI
                     GEINQYINPAKIESSQKFGIRLTYDAQLNSFYIYASIYKQSAHFLIIENICIHRYATLA
                     VLAEKLFISQSTLKRKIAVINQTLEKYGFWIDTKSVDMVGDERKIRFFYYCYLLEKYDV
                     LDLVAPEQELRVIDELISEFFAQFPSLQGPERQVFSYLNKLRTMLFISFKRLKKGCRLD
                     SHDQIDEQYSLLLSEKLSKKIAVCYHIDCTKDVLHQLFFLFFNRRYAWSANDLQKKAEH
                     DEAIAKVRRTLLAFFAKIEKSEQLVLINKDELLLLLYNATSYTWTSAKILHNPSEDFFV
                     NLNHYHEGFARRIKKELVACLNREQLDIYLDDSVINQLLFMLVTAWKGLMDQLEASAPR
                     VKAGIFFNTSFEHSQFLLNDISYHLKSRLDMTLITAKTISELRQQCQHVDMLITNLSML
                     PSPDCHTVSIQANLTPKDFENILSVYSEIVNANVTAS"
     PFAM_domain     1373..1516
                     /aSDomain="Mga"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05043.15"
                     /description="Mga helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2590_0019"
                     /evalue="2.10E-04"
                     /label="ctg1_2590"
                     /locus_tag="ctg1_2590"
                     /protein_end="59"
                     /protein_start="11"
                     /score="21.9"
                     /tool="antismash"
                     /translation="HFRIVRFLLGREWVTIGELAHTLRIPSRTIRQSIGEINQYINPAK
                     IES"
     PFAM_domain     1571..1810
                     /aSDomain="Mga"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05043.15"
                     /description="Mga helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2590_0020"
                     /evalue="1.30E-17"
                     /label="ctg1_2590"
                     /locus_tag="ctg1_2590"
                     /protein_end="157"
                     /protein_start="77"
                     /score="64.2"
                     /tool="antismash"
                     /translation="IYASIYKQSAHFLIIENICIHRYATLAVLAEKLFISQSTLKRKIA
                     VINQTLEKYGFWIDTKSVDMVGDERKIRFFYYCYL"
     PFAM_domain     1928..2425
                     /aSDomain="PRD_Mga"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08270.13"
                     /description="M protein trans-acting positive regulator
                     (MGA) PRD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2590_0021"
                     /evalue="1.30E-06"
                     /label="ctg1_2590"
                     /locus_tag="ctg1_2590"
                     /protein_end="362"
                     /protein_start="196"
                     /score="28.6"
                     /tool="antismash"
                     /translation="VFSYLNKLRTMLFISFKRLKKGCRLDSHDQIDEQYSLLLSEKLSK
                     KIAVCYHIDCTKDVLHQLFFLFFNRRYAWSANDLQKKAEHDEAIAKVRRTLLAFFAKIE
                     KSEQLVLINKDELLLLLYNATSYTWTSAKILHNPSEDFFVNLNHYHEGFARRIKKELVA
                     CLN"
     CDS             complement(2972..3721)
                     /locus_tag="ctg1_2591"
                     /transl_table=11
                     /translation="LSVMKFDKLVSGKNLSETEQEVLHYMVANIDRVLDMGVRGVAKAN
                     FTSATTVMRLAHKMGYRGFVELQYKLMTMLRHDSMRTAASDQQDQLLTAMTSHNDLSTI
                     KTVAQRIAAVEDRYLYVYAAGFSGVIGNYMFKKFQILGKRCFFSTPGDSAALLENYLED
                     LGLFLVVSKSGETQSVLDKARLVSSLPIPIVAFTGNPESTLAKIADWTLTVPDEFPLDD
                     LNQRASLFYPRMLAAFELVIGEVEKLD"
     PFAM_domain     complement(3074..3367)
                     /aSDomain="SIS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01380.24"
                     /description="SIS domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2591_0023"
                     /evalue="1.10E-10"
                     /label="ctg1_2591"
                     /locus_tag="ctg1_2591"
                     /protein_end="216"
                     /protein_start="118"
                     /score="41.5"
                     /tool="antismash"
                     /translation="LYVYAAGFSGVIGNYMFKKFQILGKRCFFSTPGDSAALLENYLED
                     LGLFLVVSKSGETQSVLDKARLVSSLPIPIVAFTGNPESTLAKIADWTLTVPD"
     PFAM_domain     complement(3503..3685)
                     /aSDomain="HTH_6"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01418.19"
                     /description="Helix-turn-helix domain, rpiR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2591_0022"
                     /evalue="4.00E-10"
                     /label="ctg1_2591"
                     /locus_tag="ctg1_2591"
                     /protein_end="73"
                     /protein_start="12"
                     /score="39.6"
                     /tool="antismash"
                     /translation="KNLSETEQEVLHYMVANIDRVLDMGVRGVAKANFTSATTVMRLAH
                     KMGYRGFVELQYKLMT"
     CDS             complement(3795..4280)
                     /locus_tag="ctg1_2592"
                     /transl_table=11
                     /translation="MFGLFKKEKSDVFTAPVTGQLMPLDALNDGVFSEKMMGEGYAVAP
                     EEQAVYAPIAGTISSVFPTKHAIGITSDAGLEVLVHMGLDTVEMNGTPFETKVAAGDQV
                     KAGDLLSTVDVAAIQASDRDAAIVVIFTNMDKVKDFSPIKAGPVTHGDAVTTLTYAG"
     PFAM_domain     complement(3873..4244)
                     /aSDomain="PTS_EIIA_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00358.22"
                     /description="phosphoenolpyruvate-dependent sugar
                     phosphotransferase system, EIIA 1"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2592_0024"
                     /evalue="1.90E-48"
                     /label="ctg1_2592"
                     /locus_tag="ctg1_2592"
                     /protein_end="136"
                     /protein_start="12"
                     /score="163.5"
                     /tool="antismash"
                     /translation="FTAPVTGQLMPLDALNDGVFSEKMMGEGYAVAPEEQAVYAPIAGT
                     ISSVFPTKHAIGITSDAGLEVLVHMGLDTVEMNGTPFETKVAAGDQVKAGDLLSTVDVA
                     AIQASDRDAAIVVIFTNMDK"
     aSDomain        complement(3882..4241)
                     /aSDomain="TIGR00830"
                     /aSTool="tigrfam"
                     /description="PTBA: PTS system, glucose subfamily, IIA
                     component"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2592_0004"
                     /evalue="1.60E-42"
                     /identifier="TIGR00830"
                     /label="ctg1_2592"
                     /locus_tag="ctg1_2592"
                     /protein_end="133"
                     /protein_start="13"
                     /score="142.3"
                     /tool="antismash"
                     /translation="TAPVTGQLMPLDALNDGVFSEKMMGEGYAVAPEEQAVYAPIAGTI
                     SSVFPTKHAIGITSDAGLEVLVHMGLDTVEMNGTPFETKVAAGDQVKAGDLLSTVDVAA
                     IQASDRDAAIVVIFTN"
     CDS             complement(4796..4996)
                     /locus_tag="ctg1_2593"
                     /transl_table=11
                     /translation="MKIQFGEDIKVEQLSVIIGGKKGIDWGKVGAAGVGCGLITWWTGP
                     GAVADGALCAATQFFGEVLKN"
     CDS             complement(5001..5255)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2594"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.4e-10,
                     bitscore: 38.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQNSQALNLKEMETIVGGYGQGDCLATIAGTAATGVKGGATAGAI
                     ATTGPFAGVGALAGAVSGGTLGITAGGLACLVGFALGGE"
     PFAM_domain     complement(5058..5255)
                     /aSDomain="Bacteriocin_IIc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10439.11"
                     /description="Bacteriocin class II with double-glycine
                     leader peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2594_0025"
                     /evalue="7.60E-07"
                     /label="ctg1_2594"
                     /locus_tag="ctg1_2594"
                     /protein_end="66"
                     /protein_start="0"
                     /score="29.2"
                     /tool="antismash"
                     /translation="MQNSQALNLKEMETIVGGYGQGDCLATIAGTAATGVKGGATAGAI
                     ATTGPFAGVGALAGAVSGGTL"
     CDS             complement(6204..6725)
                     /locus_tag="ctg1_2595"
                     /transl_table=11
                     /translation="MTVKSEVLDLTSNGHRVTFHNVTDQVKQFVKASGVQNGICVVQSP
                     HTTCSVIFEEFTHDRDFNGDEYLLVDMSRQLDKLVPRELTENTNYKYPGPKHIDFLHSI
                     QDNPAYKGDDGTVLNGDAHIRASMFGASETFVIRDGEIQTGSVGSIYFVDWDQNRVRTR
                     HCNVLVQGEA"
     PFAM_domain     complement(6225..6665)
                     /aSDomain="UPF0047"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01894.19"
                     /description="Uncharacterised protein family UPF0047"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2595_0026"
                     /evalue="3.20E-33"
                     /label="ctg1_2595"
                     /locus_tag="ctg1_2595"
                     /protein_end="167"
                     /protein_start="20"
                     /score="114.4"
                     /tool="antismash"
                     /translation="NVTDQVKQFVKASGVQNGICVVQSPHTTCSVIFEEFTHDRDFNGD
                     EYLLVDMSRQLDKLVPRELTENTNYKYPGPKHIDFLHSIQDNPAYKGDDGTVLNGDAHI
                     RASMFGASETFVIRDGEIQTGSVGSIYFVDWDQNRVRTRHCNV"
     CDS             complement(6722..7414)
                     /locus_tag="ctg1_2596"
                     /transl_table=11
                     /translation="MASVKKPFFIVNPKSYLYGDDAVKLAKIADEIAAEKHLDCLFTGQ
                     LIDLPRIKAATSHLIITAQHMDPLLPGRGMGHVLPEALKAADVEAVVLNHAENPLEIGV
                     LDKTITRAKAVGLMTIVCSDTPSESRAIASLHPTMMICEPTSLIGTGSISNDDYIKATN
                     DAVRSVDPDILIMQAAGVSTGADVKKVLALGADGTGGTSGIINAPDWRAKLTEMMGAMV
                     AYKEAQLA"
     PFAM_domain     complement(6821..7390)
                     /aSDomain="TIM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00121.20"
                     /description="Triosephosphate isomerase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2596_0027"
                     /evalue="4.00E-14"
                     /label="ctg1_2596"
                     /locus_tag="ctg1_2596"
                     /protein_end="198"
                     /protein_start="8"
                     /score="52.8"
                     /tool="antismash"
                     /translation="FIVNPKSYLYGDDAVKLAKIADEIAAEKHLDCLFTGQLIDLPRIK
                     AATSHLIITAQHMDPLLPGRGMGHVLPEALKAADVEAVVLNHAENPLEIGVLDKTITRA
                     KAVGLMTIVCSDTPSESRAIASLHPTMMICEPTSLIGTGSISNDDYIKATNDAVRSVDP
                     DILIMQAAGVSTGADVKKVLALGADGT"
     CDS             complement(7448..8311)
                     /locus_tag="ctg1_2597"
                     /transl_table=11
                     /translation="MLISSKNLLLTAREGGFAIPHFNFWDEMSARAHVAAAEKKNVPIL
                     LAWAQKHEADIDIDEALTLGKFYGAQAKVPIVLHLDHGFSPDLVKYGIDHGFTSVMIDA
                     SAEKFDKNVAVTKDVVDYAHQRGVVVEAEIGHVGTGLSADDANQYTEVEAAVEFVKRTN
                     VDSLAVSIGTSHGVYKSAKTPHLNFERLSELRQAVAVPLVLHGGSSSGDENLSKAAALG
                     ITKVNIYTDLANAALHAAQAEPYESVLKMIEAEQKAVEALDEHYVDVFNTAKLHQVEEK
                     TVLGAL"
     PFAM_domain     complement(7493..8299)
                     /aSDomain="F_bP_aldolase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01116.22"
                     /description="Fructose-bisphosphate aldolase class-II"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2597_0028"
                     /evalue="2.50E-79"
                     /label="ctg1_2597"
                     /locus_tag="ctg1_2597"
                     /protein_end="273"
                     /protein_start="4"
                     /score="266.7"
                     /tool="antismash"
                     /translation="SKNLLLTAREGGFAIPHFNFWDEMSARAHVAAAEKKNVPILLAWA
                     QKHEADIDIDEALTLGKFYGAQAKVPIVLHLDHGFSPDLVKYGIDHGFTSVMIDASAEK
                     FDKNVAVTKDVVDYAHQRGVVVEAEIGHVGTGLSADDANQYTEVEAAVEFVKRTNVDSL
                     AVSIGTSHGVYKSAKTPHLNFERLSELRQAVAVPLVLHGGSSSGDENLSKAAALGITKV
                     NIYTDLANAALHAAQAEPYESVLKMIEAEQKAVEALDEHYVDVFNTA"
     aSDomain        complement(7589..8311)
                     /aSDomain="TIGR00167"
                     /aSTool="tigrfam"
                     /description="cbbA: ketose-bisphosphate aldolase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2597_0005"
                     /evalue="2.90E-67"
                     /identifier="TIGR00167"
                     /label="ctg1_2597"
                     /locus_tag="ctg1_2597"
                     /protein_end="241"
                     /protein_start="0"
                     /score="225.0"
                     /tool="antismash"
                     /translation="MLISSKNLLLTAREGGFAIPHFNFWDEMSARAHVAAAEKKNVPIL
                     LAWAQKHEADIDIDEALTLGKFYGAQAKVPIVLHLDHGFSPDLVKYGIDHGFTSVMIDA
                     SAEKFDKNVAVTKDVVDYAHQRGVVVEAEIGHVGTGLSADDANQYTEVEAAVEFVKRTN
                     VDSLAVSIGTSHGVYKSAKTPHLNFERLSELRQAVAVPLVLHGGSSSGDENLSKAAALG
                     ITKVNIYTDLANAALHAAQ"
     CDS             complement(8311..8613)
                     /locus_tag="ctg1_2598"
                     /transl_table=11
                     /translation="MTQKLLVICGTGVATSTVVMGKLKTWLDNQGLTKDVTLYQSKVAE
                     EVNHIDDYDIVVSTTLVPDSIKEKVIDGVPLLTGINADKVYDKIKQDIETGKEKK"
     PFAM_domain     complement(8353..8604)
                     /aSDomain="PTS_IIB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02302.19"
                     /description="PTS system, Lactose/Cellobiose specific IIB
                     subunit"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2598_0029"
                     /evalue="1.40E-10"
                     /label="ctg1_2598"
                     /locus_tag="ctg1_2598"
                     /protein_end="87"
                     /protein_start="3"
                     /score="41.8"
                     /tool="antismash"
                     /translation="KLLVICGTGVATSTVVMGKLKTWLDNQGLTKDVTLYQSKVAEEVN
                     HIDDYDIVVSTTLVPDSIKEKVIDGVPLLTGINADKVYD"
     CDS             complement(8690..10027)
                     /locus_tag="ctg1_2599"
                     /transl_table=11
                     /translation="MQVLQWIVNLGASVFLPILLFLFGLALRIKPGKAFKSALTIGIGF
                     IGLNLVINLLTTSLGPATKSMISNYGLHLSSIDVGWPAASAIAYGTALGAMAIPVGVGT
                     NIILLILGLTKTLDVDIWNYWHVAFAGSILYTLTGNMWLGLATMVVVTMFTYFFADLSA
                     PTVGKYYGLEGISFPHGLSAPGYVFALPFNWLFDRIPGINKIHLDAETIQKRLGVFGDT
                     TVIGAIIGLIIGFLAQQPLNKVLNLAVSMAAVMMLMPRMVSLLMEGLTPISEGANDMIK
                     KHFPGRKLYIGMDSALAIGQGSVLSSALLLVPITLLLAIVLPGNKVLPFGDLATIPFFI
                     ALFAAVFKGDIFRTVVAGTVDIAISLYVASWAAPLITKLAKAASFNMGGNNSISALSDG
                     GLWTNFIYLMMGEKFQWLGVGVLFIVALGLLFWLNKVREKQEKVTA"
     PFAM_domain     complement(8870..10009)
                     /aSDomain="EIIC-GAT"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03611.16"
                     /description="PTS system sugar-specific permease component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2599_0030"
                     /evalue="1.10E-84"
                     /label="ctg1_2599"
                     /locus_tag="ctg1_2599"
                     /protein_end="386"
                     /protein_start="6"
                     /score="285.0"
                     /tool="antismash"
                     /translation="IVNLGASVFLPILLFLFGLALRIKPGKAFKSALTIGIGFIGLNLV
                     INLLTTSLGPATKSMISNYGLHLSSIDVGWPAASAIAYGTALGAMAIPVGVGTNIILLI
                     LGLTKTLDVDIWNYWHVAFAGSILYTLTGNMWLGLATMVVVTMFTYFFADLSAPTVGKY
                     YGLEGISFPHGLSAPGYVFALPFNWLFDRIPGINKIHLDAETIQKRLGVFGDTTVIGAI
                     IGLIIGFLAQQPLNKVLNLAVSMAAVMMLMPRMVSLLMEGLTPISEGANDMIKKHFPGR
                     KLYIGMDSALAIGQGSVLSSALLLVPITLLLAIVLPGNKVLPFGDLATIPFFIALFAAV
                     FKGDIFRTVVAGTVDIAISLYVASWAAPLITKLAKAASFN"
ORIGIN
        1 ctttactgta cttcgaattt aaggactaat ttataatttg ccttaactgt ctctttggtg
       61 aagtcaaaac cctttttgac acttccagcc aaagtaaact ggattttccc gttttggctt
      121 gtgatcgtac caatctcagt aggaaaagaa ggtacttttt gtttgtcagt tgaacgcaaa
      181 gcaatctttt tgccgtctga gtttaaattt agatccaagc gaccctctaa tttattagca
      241 ttatcgccat cagtaaaatc attaatggaa actttgacgc ctttggctga tagattctgg
      301 atttcataat tcggtgaaat aataccttca ctgacgtcgg tttgactaaa caaaactttg
      361 gagggaattt tgacatcaac ccatgcttta tgatcttttt taggcgttgg tttagccgga
      421 tcaggtagtt tggtaggatc aaatggttca aacgttcctt cagccgaaat cgttgcactg
      481 tctgttttct tcacttctag cgtgttagta gcagcatgag gatcattttg gccattttcg
      541 taagcgtaca cttgggttga tccaagcagt gatgccccta tagctaatac gccgcatagt
      601 gtcagaagtt ttgtctttgt ctttttcatt tttgttcctc cattagtttg cttttattga
      661 taactagcag actagttatt cactgataat tgaccgacaa ttgcggtttc accgattttt
      721 gttgaagaat cggcaagttc ataataggta acggtgcttt gtgtcttata aacgcctctt
      781 ttaaggttgg ctttcaattc accagcctca acatattgtt tgggcttaat taaaccggaa
      841 tcgtaaatga ctttgttctg tccttctaat cgtgtttgca cccgaatacc atactggttg
      901 ctcgcaggat tcaagatatt gaccgtcccg acttcatttg cggcattgaa aaccatattc
      961 gtatcaagct ttaaatgaaa tttgcttttg tcggcttttt cttgcagata ttctttgagt
     1021 tcttcatccg tcatattctt cacgaaggaa gtgtcttcag caccacctcc atttgcaaca
     1081 acattgggaa cgcttctgtg caagtacatg tagcttccaa tgctgacaat cccaactaat
     1141 aaaagcagta agactaccag tttcaatttt ttgttttttt gcatgcaatt tttcaacctt
     1201 cccaattgaa ttccaaatcg aaacggtgtt ataatgcacc tgatattagc aatttctaac
     1261 aatgaaagtt agtataatct aatttcccgc ctagttgaag ttcacttttt gcctaacgtt
     1321 aggcaaagaa ggagagttta tggaagaact tttagaaagc aatttgctta gacactttcg
     1381 gattgttcgc tttttacttg gccgagaatg ggtgacaatt ggcgaactcg ctcatacatt
     1441 gcgtattcca tccagaacga ttcgccaaag catcggggaa ataaatcaat acattaatcc
     1501 cgctaaaatt gaaagtagtc agaaatttgg tatccgattg acctatgacg ctcaacttaa
     1561 ttctttttat atctacgcat cgatctataa acaatcggcg cactttttaa ttatcgaaaa
     1621 tatttgtatc catcgatatg caacgctggc tgttttagcc gaaaaacttt tcattagtca
     1681 gtcaacctta aaaaggaaga tagcggtcat caatcaaact ttggaaaaat acggtttttg
     1741 gattgatacc aagtcagtgg acatggtcgg cgatgagaga aagattcgct ttttttatta
     1801 ttgctatttg cttgaaaaat atgatgtcct tgatcttgtc gcgcctgagc aggaacttcg
     1861 tgtcatagat gagcttattt cggagttttt cgcccaattt ccgtctttac agggccccga
     1921 gcgacaggtc ttttcttatt tgaataaact tcggacgatg ctgttcatca gttttaaaag
     1981 gcttaaaaaa gggtgccgct tagatagtca cgatcaaatc gacgaacagt attccctttt
     2041 actttcagaa aagttaagta aaaaaatagc ggtctgctat cacattgact gcacaaaaga
     2101 cgttcttcat cagttgttct ttttattctt caaccgaaga tatgcttggt ccgctaatga
     2161 tcttcaaaaa aaagctgaac acgatgaagc catcgcaaaa gtccgtcgta ctttgctggc
     2221 gtttttcgcg aagatcgaaa aaagtgaaca actggttcta attaacaaag atgagctttt
     2281 gttgctgctt tacaacgcaa cgagctacac ctggacttca gctaaaatct tgcataaccc
     2341 tagcgaagac ttctttgtca atctaaatca ttaccatgaa ggatttgccc gccgcatcaa
     2401 aaaagaattg gtcgcttgtt taaacagaga acagctcgac atctacctgg atgattcggt
     2461 gatcaatcaa ttactgttta tgctcgttac cgcttggaaa ggcttgatgg atcagctaga
     2521 agcgagcgcc ccacgagtaa aggcggggat tttctttaat actagttttg aacacagtca
     2581 gtttttgctg aacgacattt catatcatct gaaatctcgg cttgatatga cactgatcac
     2641 tgccaaaacg atcagcgagt tgcgccaaca atgtcaacat gttgatatgc tgattactaa
     2701 tctatctatg ctgccatcac ctgactgcca tactgtttcg atccaagcaa acctcacgcc
     2761 aaaagatttc gaaaacattc tctccgtcta tagcgagatt gtgaacgcca acgtcacagc
     2821 ctcttgacac agtatggaaa gtgactacga tttatcaacg taaaaaagtc agagcacggt
     2881 ccggatttcg gagcgcgctc tggcttttaa catgtcttaa ccttctcgtc attatatctg
     2941 ctaataaaac cagacatcaa caacgcctag ctcaatccag cttctcaact tctccaatca
     3001 ccaattcaaa cgccgccaac atccgtggat aaaacagcga agcacgttgg ttgagatcgt
     3061 ctaagggaaa ctcatccggg acggtcagcg tccagtcggc tattttagcc aatgtgcttt
     3121 ctgggttgcc agtaaacgct acaattggga tcggcaaact gctgaccaat ctcgccttat
     3181 ctaagacact ctgcgtttcg ccagacttag aaacgactag gaacaagccg agatcttcca
     3241 aatagttttc caaaagcgct gccgagtctc ctggcgtcga gaaaaagcaa cgcttaccaa
     3301 gaatttgaaa ctttttaaac atataatttc caatcacacc ggaaaaccct gccgcataaa
     3361 cgtacaggta acgatcttca acggcggcga tacgctgggc aacggtcttg atggtgctta
     3421 gatcgttgtg actggtcatc gccgtcagca actgatcctg ctggtcgctc gccgctgttc
     3481 tcatgctatc atgccgcaac atcgtcatga gcttatattg cagctcgaca aaaccgcgat
     3541 agcccatttt gtgcgccaat cgcatgaccg ttgtcgccga tgtaaagttt gctttcgcca
     3601 caccgcgaac gcccatgtcc aacacccgat caatattcgc caccatgtag tgcaacactt
     3661 cctgctcggt ctcagaaagg tttttccctg aaactaactt atcgaatttc attacactca
     3721 aaaatccctt ctgaaaacga cacagtcctt ataaaaaagc cgccaccttg attaccagtg
     3781 gtcgaccttc tacgttagcc agcataggtt aatgtcgtca cggcatcgcc atgcgtcacc
     3841 ggccctgctt tgatgggtga aaaatccttc accttgtcca tgttggtaaa aatcaccaca
     3901 atcgcagcat cgcgatccga ggcctgaata gcagcaacat caaccgtcga cagcaaatcc
     3961 cccgccttca cctgatctcc ggcggcaacc ttggtctcaa acggcgtccc attcatctct
     4021 accgtatcaa gtcccatgtg aactaacact tcaagtcccg catcggatgt aatcccaatc
     4081 gcatgttttg tcgggaaaac cgaactgatc gtcccagcaa tcggagcata aaccgcttgt
     4141 tcttctggcg caaccgcgta cccctcgccc atcatcttct ctgaaaagac accatcgtta
     4201 agcgcatcaa gcggcattaa ctggcctgtc actggtgctg taaaaacatc acttttttct
     4261 tttttaaata gcccgaacat tcattgccat ccccttctgg ttatcagtca ccatgatcaa
     4321 tttttacaga taaccgcggt tattgcaaac gtttactttt aattgagggg taattgctta
     4381 ttttggtggc tcaccatggt tttctagtac caaccaccgt cagcttgacg gcttttcaga
     4441 ctaaacgctt tttcaatgtt tgaatatcgc atttcccacg acaaacatct gacataaact
     4501 gttaatacaa ataaccgtct cctctgatca gaaaacggct attatgcgat ataactattt
     4561 catgagttgc ttgcggagcg ggatattggt caggacaata tctagaaacc gaaaatcatc
     4621 gggataacaa ccgtacatat gccgataaag cctatccaca ttgagtccag caaccgtctt
     4681 cgaatcaaat cacgacgatt acgatgaacc aaccaaagta ttctaacaat tgtgaatatt
     4741 attactaaaa tgatttccaa acatatgatc ctgaaaacaa aattccaatt actcattagt
     4801 ttttcagaac ttcaccaaaa aattgtgtag cagcacacaa cgcgccatct gcaactgcgc
     4861 cgggtccagt ccaccaggtg ataagaccgc acccaacacc ggcggcgcca accttacccc
     4921 aatcaattcc ctttttcccg ccaataataa cggaaagttg ttcaactttg atatcttcac
     4981 caaactgaat tttcataaga ttattcgcct cctaatgcaa acccaactag gcatgctaaa
     5041 ccaccagcag taatacccaa ggttccacca ctgacggctc cagcaagagc gccgacaccg
     5101 gcaaatggtc cagttgttgc tattgcacct gctgtagcac cacctttcac gccagtagca
     5161 gcagttcccg caatcgttgc aaggcaatca ccttgcccat atcctccaac gatcgtttcc
     5221 atttccttta aattcaatgc ctgactattc tgcataattt tattacctca tctttctgaa
     5281 atcctagtaa ccctctatct acaaagtcca aagtgtttag ctcagcttaa tttctattag
     5341 ttattctcac cctctcttat aagaaaacac gttgtagtta agttgagagc tctctcaatt
     5401 aataatatac aagaccttga acactctttg ctgcctaaaa tttaaacgtc gtctttttag
     5461 cttttaacgt cgcttgaagg tataggcgga ctataaaacg gtaaaatacg acattatttt
     5521 tttgcatttt tcaattttaa tcctataact ttaaaatcga catcattgtg acgccttgat
     5581 accgcatgct ataatggaga cacaaaaggg agcagtggct gctaccagta ctcccctgac
     5641 aaggccgctt aagacggctg gcatttacag tcaaagggcc gttagacttc ctgccagaaa
     5701 tctagtgacg gtcttttttg ctgtctagga ttaaaatcaa catcattgca gcgcttagat
     5761 cctgcatgct ataatgaaga tacaaaaggg agcaccggcc gtaaccagta ctcccttgac
     5821 aagaccgttg aagacggtca acattcgttt aagcaatcaa ttaagaccgt caaactctgt
     5881 caaaagtttt agtgacggtc tttttgattg tctagaattg ctaccacaat cgtgacgatg
     5941 agtgcaatca atgatagtat gaaaccacca aagaccagca tcagcatcaa ggcgtcagca
     6001 acggacaact aggcacctcc cttcgtatag attttgatca tcgcgcatag gcgatcacct
     6061 cacaatacgt tggatttgcc aaccgtcatt cactttcttg tctcatccat tatgccatac
     6121 caaatagcaa aacgcctaga gtcgcaaaga ttctaggcgt tttttaattc gttaaaatag
     6181 tgtttatcta aaaatacctg ccatcaagct tcaccctgta ccagcacatt gcaatgtctt
     6241 gtacggacgc gattttggtc ccagtcaaca aagtaaatag acccaactga tccggtttga
     6301 atctcaccat cacgaatcac aaaagtttcg cttgcgccga acattgaagc tcgaatgtgg
     6361 gcatctccat tcaaaacagt gccatcatca cctttatagg cagggttgtc ctgaatgcta
     6421 tgcaggaagt caatatgctt agggccagga tacttatagt tcgtattttc cgtgagttct
     6481 cgcgggacca atttatccag ttgacggctc atatcgacta gcagatactc gtcgccatta
     6541 aagtcccgat catgcgtaaa ttcttcaaag atcaccgaac aagtcgtatg tggtgattga
     6601 acgacacaaa tgccattttg aacgccactg gccttcacaa attgtttcac ctgatcagtc
     6661 acattatgaa atgtcacccg atggccattt gaagttagat ccaacacttc acttttaact
     6721 gtcatgctaa ctgtgcctcc ttgtatgcca ccattgcacc catcatttcc gtcaattttg
     6781 cgcgccaatc aggggcatta ataataccgc ttgtgccacc agttccatca gcacccaatg
     6841 ccaatacctt tttgacgtct gcgccagtac taacgccagc tgcttgcatg atcaaaatgt
     6901 caggatcaac actgcgaacg gcatcattgg ttgctttaat atagtcatca ttgctgatac
     6961 ttccggtccc aattaaactg gttggttcgc aaatcatcat ggttgggtgc agactcgcaa
     7021 tcgcgcgact ttcagaaggc gtgtcggaac agacaatggt cattaaaccg accgctttag
     7081 cacgggtaat cgtcttatcc aaaacaccga tttccagcgg attttcagca tgattcagga
     7141 caaccgcttc aacatccgca gctttcaggg cttcaggtaa aacatggccc atgccacggc
     7201 cgggaagcag cgggtccatg tgctgtgccg tgatgatcaa gtggctcgtt gccgccttga
     7261 tccgtggcag atcaatcagt tgccccgtaa ataaacagtc aagatgcttt tcggcagcaa
     7321 tctcatccgc aatttttgcc agcttcacgg catcatcacc ataaagatac gacttaggat
     7381 tcacaatgaa aaaaggtttc ttaacacttg ccattccaac atcacccttt cttgaaaaga
     7441 ttgaaactca cagcgcaccg agtaccgttt tctcttcaac ttgatgcaac ttggccgtat
     7501 tgaaaacatc aacatagtgc tcatccagtg cttcaactgc tttctgttcg gcttcgatca
     7561 tcttaagaac actttcataa ggctctgctt gggctgcatg caaggcagca ttggccaagt
     7621 cagtgtagat attgacctta gtgataccca gtgccgcggc cttgcttaaa ttctcatcac
     7681 cagatgacga cccaccgtgg agaaccaatg gcactgcaac tgcttgtcgc aattcactga
     7741 gccgctcaaa attcagatgt ggtgtcttgg cactcttata aaccccgtgc gaggtgccga
     7801 ttgacacggc taaagaatca acgttggtac gtttaacaaa ctcgacagcc gcctcaacct
     7861 cggtatactg attggcgtca tccgcactca agccagtgcc gacatggccg atttccgcct
     7921 caacaacgac cccgcgttga tgggcataat caacgacatc cttcgtcacg gcaacgtttt
     7981 tatcgaactt ttcagcagag gcgtcaatca tcaccgacgt aaagccatga tcaataccat
     8041 atttgaccag gtctggtgag aacccatgat cgaggtgcag aacaatgggg accttggctt
     8101 gggcgccata gaatttgcct agagtcaaag cttcatcaat atcaatatcg gcttcatgct
     8161 tctgtgccca tgccaacaat atcggcacat ttttcttctc agcagctgct acatgggcgc
     8221 gagctgacat ttcatcccaa aagttgaagt gtggaatcgc aaaaccacct tcgcgcgccg
     8281 ttaacaacaa gttttttgaa gaaatgagca ttattttttc tcctttcctg tttcaatatc
     8341 ctgcttgatc ttgtcgtaaa ctttgtcggc attaatgcca gtcagcaatg gtaccccatc
     8401 aatgactttc tctttaatcg aatctggcac caatgttgtg gaaaccacga tgtcataatc
     8461 atcaatatga ttgacttcct cagccacttt gctttggtac aacgtcacgt cttttgtaag
     8521 tccttgattg tccaaccaag tcttaagctt gcccatgacg acagttgaag ttgcaacacc
     8581 ggtaccgcag ataactaata acttttgtgt catgattttt ctcctttttt gtaagcacga
     8641 gccggcctaa caatcaggct gcatctcacg ttttctagct acaatgaact taggctgtaa
     8701 ctttttcttg cttttcccgg actttgttaa gccagaatag taaacccaaa gcaacgatga
     8761 acaacacgcc gacgccgagc cactggaact tttcacccat catgagatag ataaagttgg
     8821 tccacaatcc gccatcactc aaggctgaga tagagttgtt gccacccata ttgaaactgg
     8881 cagccttggc tagtttggtg atcaacggcg ccgcccaact cgcaacatag aggctaatcg
     8941 caatatcaac ggtccccgcc accacggttc tgaaaatatc gcctttaaaa acggcggcaa
     9001 acaatgcgat gaagaatgga atcgttgcta aatcaccaaa cggtaagacc ttgtttcctg
     9061 gcaaaacaat ggccagtagt aacgtgatcg gcactaacag cagtgctgat gacaaaacgg
     9121 aaccttgccc aatggccaaa gcactatcca tcccgatgta taacttgcga cctgggaaat
     9181 gctttttgat catgtcattg gcgccttcag agatgggcgt taagccttcc atcagcagtg
     9241 aaaccatgcg cggcatcaac atcatgaccg ccgccatgct gacagccaga ttcagaacct
     9301 tattcagtgg ttgttgggca agaaagccga tgattaaacc gataatggcg ccgatgactg
     9361 tcgtatcacc aaacacacct aagcgttttt gaattgtttc agcgtccaga tggatcttat
     9421 tgatgccagg aatccgatca aacaaccagt tgaatggcaa cgcgaagacg taacccgggg
     9481 ctgacaaacc atgagggaag gaaatgcctt ccaagccgta atacttaccg acagttggcg
     9541 cactcagatc agcgaagaag taagtgaaca ttgtcaccac aaccatcgtg gcaagcccca
     9601 gccacatgtt gcctgtcagt gtgtacaaaa tggaaccggc aaacgcgacg tgccaataat
     9661 tccaaatatc gacatccagc gttttggtta ggccaagaat caacaaaata atattcgtac
     9721 caacgccaac aggaatggcc atcgcgccta atgctgtgcc atatgcgatc gctgaagctg
     9781 ctggccaccc aacatcaatg ctgctgagat gcaaaccata attactgatc attgactttg
     9841 ttgctggtcc taaactggtt gtcagtaaat taatcaccaa gttcagacca ataaacccaa
     9901 tcccaattgt cagtgcggat ttaaacgctt tgcctggttt gattcgcaat gcgagtccaa
     9961 aaagaaacaa tagtattggc aagaagacac tcgcccctaa attgacgatc cattgaagta
    10021 cttgcattga agttctcctc ctttaaacgc gtttacagtc gcagaaattt ccagataagc
    10081 gcgcttgttc acgctctctt taaacaactg ccttgctgca aaatttccca cacgtgccgt
    10141 tacaaaacac cctgttccgt catgaaatga atgaagtcat ctgctgtctt aattttccta
    10201 aaagctgtca tttctgcatc atcagcaaac aatcccatta atttctgcaa catat
//
