LOCUS       c00002_NZ_RBIZ..       10990 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_RBIZ01000004.1 Yokenella regensburgei strain DSM 5079
            Ga0215677_102, whole genome shotgun sequence.
ACCESSION   NZ_RBIZ01000004
VERSION     NZ_RBIZ01000004
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:59:16
            Original ID  :: NZ_RBIZ01000004.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 102755
            Orig. end    :: 113745
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10990
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[107755:108745](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5990)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     cand_cluster    1..10990
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10990
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="1"
                     /rules="AfsA"
                     /tool="antismash"
     CDS             1011..1247
                     /locus_tag="ctg2_87"
                     /transl_table=11
                     /translation="MSTDKALLEAGYRQYSGEKIDVYFNTDICQHSGNCVRGSHQLFDL
                     KRKPWIMPDEVDVATVVKVIDTCPSGALKYRHK"
     PFAM_domain     1053..1244
                     /aSDomain="Fer4_19"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06902.13"
                     /description="Divergent 4Fe-4S mono-cluster"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_87_0001"
                     /evalue="1.50E-28"
                     /label="ctg2_87"
                     /locus_tag="ctg2_87"
                     /protein_end="78"
                     /protein_start="14"
                     /score="98.7"
                     /tool="antismash"
                     /translation="YSGEKIDVYFNTDICQHSGNCVRGSHQLFDLKRKPWIMPDEVDVA
                     TVVKVIDTCPSGALKYRHK"
     CDS             1259..1531
                     /locus_tag="ctg2_88"
                     /transl_table=11
                     /translation="MEILEGHNKFYVNDASGNQVAEIVFVPTGEHLSIIEHTDVDPSLK
                     GQGVGKKLVARVVAKMREEHRKVIPLCPFAKHEFDTTPEYNDIRA"
     PFAM_domain     1283..1522
                     /aSDomain="Acetyltransf_CG"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14542.8"
                     /description="GCN5-related N-acetyl-transferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_88_0002"
                     /evalue="1.40E-21"
                     /label="ctg2_88"
                     /locus_tag="ctg2_88"
                     /protein_end="88"
                     /protein_start="8"
                     /score="76.5"
                     /tool="antismash"
                     /translation="KFYVNDASGNQVAEIVFVPTGEHLSIIEHTDVDPSLKGQGVGKKL
                     VARVVAKMREEHRKVIPLCPFAKHEFDTTPEYNDI"
     CDS             complement(1615..3117)
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 294.3; E-value:
                     2.1e-89)"
                     /gene_kind="transport"
                     /locus_tag="ctg2_89"
                     /transl_table=11
                     /translation="METQVVEAKSSQTMILLCILIAVFVVPTSISGTAIALPAISADLH
                     SQTASLQWVVNAFNLTFASFTLAWGGLADVFGSKRSFIAGAGLYFLASVLSWSAGNIYV
                     LDAARALAGIGGAAIFSCGSAILIQTFSGAQRTRAFALFGTTAGLGITFGPTISGWLLN
                     VAGWRDIFVVHAIALFVVLILTVTIPAAVKKAEKPSLDIAGILLFIVSLFLLMTGITQG
                     AELGWSDNFTLSLLGSGLVLLLCFVAVEKRSPNPMVNFALLGNHYFLSMILIPVVASFC
                     FVTLLTWFPTWLIAMKSLSPLESGLVMLALTSPVLVLPIVAGKLVTRGVSANLLLVISL
                     VLFVGGLLLLWIFNQGSMSMGQILLSLLLVGAGMGLSAGLVDGIALSVVSAHEVGRAAG
                     ILNTFRLGSEAIAVAIYGSLMSTGIFHALASKPVPEGTTANQYLADVVSGNAFAQASAE
                     QASWLESVYTEAFSHTVLVLLVISIVISLSVVLMMRNKKVSA"
     PFAM_domain     complement(1897..3063)
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_89_0003"
                     /evalue="2.40E-44"
                     /label="ctg2_89"
                     /locus_tag="ctg2_89"
                     /protein_end="407"
                     /protein_start="18"
                     /score="151.8"
                     /tool="antismash"
                     /translation="ILIAVFVVPTSISGTAIALPAISADLHSQTASLQWVVNAFNLTFA
                     SFTLAWGGLADVFGSKRSFIAGAGLYFLASVLSWSAGNIYVLDAARALAGIGGAAIFSC
                     GSAILIQTFSGAQRTRAFALFGTTAGLGITFGPTISGWLLNVAGWRDIFVVHAIALFVV
                     LILTVTIPAAVKKAEKPSLDIAGILLFIVSLFLLMTGITQGAELGWSDNFTLSLLGSGL
                     VLLLCFVAVEKRSPNPMVNFALLGNHYFLSMILIPVVASFCFVTLLTWFPTWLIAMKSL
                     SPLESGLVMLALTSPVLVLPIVAGKLVTRGVSANLLLVISLVLFVGGLLLLWIFNQGSM
                     SMGQILLSLLLVGAGMGLSAGLVDGIALSVVSAHEVGRAAGILNTFRLG"
     CDS             complement(3127..4344)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 246.3; E-value: 8.9e-75)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_90"
                     /sec_met_domain="p450 (E-value: 3.3e-13, bitscore: 44.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VNTTAFAWPSVATIPHYDCTPGYEVLEPASYQRAGKIKLLSGHEA
                     WHVINYHDVKKVLTSNTCLRGPSNEPNGPSILPTLTPKDLLLNLDFPHHARMKRFVAKD
                     YSASGLAWLAPHMVDAIETLMQAARAGEAFDLYQDVLDPLAVQINCLLLGIPLVEKEYF
                     RVLSVTVQKADPQQVEDLIEKFTALYQYLFEHVTGVRQHADDGLIARFVAMRESATPPL
                     NDEEITAILLGSLLGGDQNTLTVMTKIFYALLCTETLWQQVVDFPETTEQVADELIRLT
                     NLGTASAFPRICSEAIELSGVTIPAGATIFPDVFLANRDPSVYASPLTIDPFRNGPRHL
                     QFGYGMHHCMGQELAKLEICTAIKTIARLAPDLRLSDHVLPENFIWNEGIILRRPAQLP
                     VCTIRK"
     PFAM_domain     complement(3247..3537)
                     /aSDomain="p450"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00067.24"
                     /description="Cytochrome P450"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_90_0004"
                     /evalue="9.20E-12"
                     /label="ctg2_90"
                     /locus_tag="ctg2_90"
                     /protein_end="366"
                     /protein_start="269"
                     /score="44.5"
                     /tool="antismash"
                     /translation="TEQVADELIRLTNLGTASAFPRICSEAIELSGVTIPAGATIFPDV
                     FLANRDPSVYASPLTIDPFRNGPRHLQFGYGMHHCMGQELAKLEICTAIKTI"
     CDS             complement(4341..4997)
                     /locus_tag="ctg2_91"
                     /transl_table=11
                     /translation="MMKIIWFDFGGVLSPSIPDLFTSYYLKTGIPPAVLQRAMKEVADD
                     LNMGVLTPIEKAIITEREWGAGIRQKLSQSVPELDLSRARLEEFGEQWFDGILPNQLMI
                     DLFRKVKATGLKVGILTNNVVEWEDHWKRVIGISEEADVIVDSCKVGCRKPEAEIFAIA
                     TERAGVRPHENLLIDDVLENCMAAEQYGWKSVHFKDSSSTVAEVIAVLQRQEVFL"
     aSDomain        complement(4410..4604)
                     /aSDomain="TIGR01509"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IA-v3: HAD hydrolase, family IA,
                     variant 3"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_91_0001"
                     /evalue="1.10E-10"
                     /identifier="TIGR01509"
                     /label="ctg2_91"
                     /locus_tag="ctg2_91"
                     /protein_end="196"
                     /protein_start="131"
                     /score="39.9"
                     /tool="antismash"
                     /translation="KRVIGISEEADVIVDSCKVGCRKPEAEIFAIATERAGVRPHENLL
                     IDDVLENCMAAEQYGWKSVH"
     PFAM_domain     complement(4413..4757)
                     /aSDomain="HAD_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13419.8"
                     /description="Haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_91_0005"
                     /evalue="1.70E-09"
                     /label="ctg2_91"
                     /locus_tag="ctg2_91"
                     /protein_end="195"
                     /protein_start="80"
                     /score="38.2"
                     /tool="antismash"
                     /translation="LSRARLEEFGEQWFDGILPNQLMIDLFRKVKATGLKVGILTNNVV
                     EWEDHWKRVIGISEEADVIVDSCKVGCRKPEAEIFAIATERAGVRPHENLLIDDVLENC
                     MAAEQYGWKSV"
     CDS             complement(5001..5990)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_92"
                     /sec_met_domain="AfsA (E-value: 6.4e-18, bitscore: 60.1,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFIEDVESEFIIRTGSYNYQNTIPKSCVHRAAVGEVFLTDIRKI
                     HDNKYITAGYLPKSHIYFNDLPYRKSSDRVYDAILLLEICRQTSIYVTHNFFAVPYSAK
                     FVFDDADFTLFDSDIPYKTECSNVIVEVDIIERKFRKSELTGLIFRMDIYVDGYCCAQK
                     IMNISWMDDRKWHRLRSQRPLECHDTTSVFAAATHEVGRQLPQNVVVGNADMHDGGVTT
                     TVIVDQDHPSIFDHPLDHVPGMLLMEAYRQTALLAMRSRLGTQSFDLVISRYNVNFTRF
                     CEFHKPVYCHARLGDIYLTDDKKSTVIPMTISQDEKLVSGAELTITFK"
     PFAM_domain     complement(5010..5393)
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_92_0007"
                     /evalue="2.40E-20"
                     /label="ctg2_92"
                     /locus_tag="ctg2_92"
                     /protein_end="327"
                     /protein_start="199"
                     /score="72.9"
                     /tool="antismash"
                     /translation="VGRQLPQNVVVGNADMHDGGVTTTVIVDQDHPSIFDHPLDHVPGM
                     LLMEAYRQTALLAMRSRLGTQSFDLVISRYNVNFTRFCEFHKPVYCHARLGDIYLTDDK
                     KSTVIPMTISQDEKLVSGAELTIT"
     PFAM_domain     complement(5490..5906)
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_92_0006"
                     /evalue="5.10E-15"
                     /label="ctg2_92"
                     /locus_tag="ctg2_92"
                     /protein_end="167"
                     /protein_start="28"
                     /score="55.7"
                     /tool="antismash"
                     /translation="VHRAAVGEVFLTDIRKIHDNKYITAGYLPKSHIYFNDLPYRKSSD
                     RVYDAILLLEICRQTSIYVTHNFFAVPYSAKFVFDDADFTLFDSDIPYKTECSNVIVEV
                     DIIERKFRKSELTGLIFRMDIYVDGYCCAQKIMNI"
     CDS             6194..6505
                     /locus_tag="ctg2_93"
                     /transl_table=11
                     /translation="MEEKVAEEAVPFDMVKVFKALADPVRLTIVRGLLADKPGAERHCS
                     TFGLTVTRATRSHHFKVLREAGLIRVVDKGNMAVAVLRWDEIENDLPGLVKLIRHTDK"
     PFAM_domain     6239..6418
                     /aSDomain="HTH_20"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12840.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_93_0008"
                     /evalue="5.00E-11"
                     /label="ctg2_93"
                     /locus_tag="ctg2_93"
                     /protein_end="75"
                     /protein_start="15"
                     /score="42.6"
                     /tool="antismash"
                     /translation="KVFKALADPVRLTIVRGLLADKPGAERHCSTFGLTVTRATRSHHF
                     KVLREAGLIRVVDKG"
     CDS             6739..7371
                     /gene_functions="transport (smcogs)
                     SMCOG1116:Homoserine/threonine efflux protein (Score:
                     138.7; E-value: 3.2e-42)"
                     /gene_kind="transport"
                     /locus_tag="ctg2_94"
                     /transl_table=11
                     /translation="MDPFHAIVLTVGLFVLTFFNPGANLFVVVQTSLASGRRAGVITGL
                     GVALGDALYSGLGLFGMATLITQCESLFSAIKIVGGAYLLWFAWKSLRRQPTPMSSALL
                     QPIVAPWHVFFRTGAITCLSNPQTVLFFISIFSVTLSAQTPTWAKLLAWCGIVLSSVIW
                     RVFLSQAFSLPAVRRGYARTQKVASRVIGVVIGAFAVKLIWEGVMRK"
     PFAM_domain     6787..7353
                     /aSDomain="LysE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01810.20"
                     /description="LysE type translocator"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_94_0009"
                     /evalue="1.70E-49"
                     /label="ctg2_94"
                     /locus_tag="ctg2_94"
                     /protein_end="205"
                     /protein_start="16"
                     /score="168.1"
                     /tool="antismash"
                     /translation="TFFNPGANLFVVVQTSLASGRRAGVITGLGVALGDALYSGLGLFG
                     MATLITQCESLFSAIKIVGGAYLLWFAWKSLRRQPTPMSSALLQPIVAPWHVFFRTGAI
                     TCLSNPQTVLFFISIFSVTLSAQTPTWAKLLAWCGIVLSSVIWRVFLSQAFSLPAVRRG
                     YARTQKVASRVIGVVIGAFAVKLIWE"
     aSDomain        6796..7344
                     /aSDomain="TIGR00949"
                     /aSTool="tigrfam"
                     /description="2A76: homoserine/Threonine efflux protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_94_0002"
                     /evalue="7.40E-64"
                     /identifier="TIGR00949"
                     /label="ctg2_94"
                     /locus_tag="ctg2_94"
                     /protein_end="202"
                     /protein_start="19"
                     /score="212.8"
                     /tool="antismash"
                     /translation="NPGANLFVVVQTSLASGRRAGVITGLGVALGDALYSGLGLFGMAT
                     LITQCESLFSAIKIVGGAYLLWFAWKSLRRQPTPMSSALLQPIVAPWHVFFRTGAITCL
                     SNPQTVLFFISIFSVTLSAQTPTWAKLLAWCGIVLSSVIWRVFLSQAFSLPAVRRGYAR
                     TQKVASRVIGVVIGAFAVKL"
     CDS             complement(7399..8211)
                     /locus_tag="ctg2_95"
                     /transl_table=11
                     /translation="MSRLLSRWQKPDASGRTQAVTPARAGWGYVGFEAYQLEEGQRLTL
                     PAASEERCLVLVAGRASIGTPTAQFSDIGERMSPFERIKPWAVYVTPGESIQVQALTKL
                     ELAVCAAPGKGNWPTRLIAPQDIDGEARGKGHNQRYVHNILPEDKPADSLLVVEVWTNE
                     GCTSSYPSHKHDTDNPPQETYLEETYYHRLNPPQGFCMQRVYTDDRELDECMAVYDRDV
                     VMVPKGYHPVATMAGYDSYYLNVMAGPVRQWMFTWEEDHAWINRDYPA"
     aSDomain        complement(7420..8157)
                     /aSDomain="TIGR04378"
                     /aSTool="tigrfam"
                     /description="myo_inos_iolB: 5-deoxy-glucuronate isomerase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_95_0003"
                     /evalue="4.00E-97"
                     /identifier="TIGR04378"
                     /label="ctg2_95"
                     /locus_tag="ctg2_95"
                     /protein_end="264"
                     /protein_start="18"
                     /score="322.6"
                     /tool="antismash"
                     /translation="AVTPARAGWGYVGFEAYQLEEGQRLTLPAASEERCLVLVAGRASI
                     GTPTAQFSDIGERMSPFERIKPWAVYVTPGESIQVQALTKLELAVCAAPGKGNWPTRLI
                     APQDIDGEARGKGHNQRYVHNILPEDKPADSLLVVEVWTNEGCTSSYPSHKHDTDNPPQ
                     ETYLEETYYHRLNPPQGFCMQRVYTDDRELDECMAVYDRDVVMVPKGYHPVATMAGYDS
                     YYLNVMAGPVRQWMFTWEEDHAWI"
     PFAM_domain     complement(7420..8184)
                     /aSDomain="KduI"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04962.14"
                     /description="KduI/IolB family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_95_0010"
                     /evalue="1.20E-109"
                     /label="ctg2_95"
                     /locus_tag="ctg2_95"
                     /protein_end="264"
                     /protein_start="9"
                     /score="365.8"
                     /tool="antismash"
                     /translation="KPDASGRTQAVTPARAGWGYVGFEAYQLEEGQRLTLPAASEERCL
                     VLVAGRASIGTPTAQFSDIGERMSPFERIKPWAVYVTPGESIQVQALTKLELAVCAAPG
                     KGNWPTRLIAPQDIDGEARGKGHNQRYVHNILPEDKPADSLLVVEVWTNEGCTSSYPSH
                     KHDTDNPPQETYLEETYYHRLNPPQGFCMQRVYTDDRELDECMAVYDRDVVMVPKGYHP
                     VATMAGYDSYYLNVMAGPVRQWMFTWEEDHAWI"
     CDS             complement(8221..9111)
                     /locus_tag="ctg2_96"
                     /transl_table=11
                     /translation="MTVQLGINPLTWTNDDLPSLGAETSLETCLSEGKEAGFAGFELGN
                     KFPREARLLGPVLQRHSLALVSGWYSGRLLERSVEEEIAAVQPHLTLLRELGAKVMVFA
                     EVTHCIHGEQQTPVHLRPRFPQERWAEYGKKLSEFARYTQQQGVQIAYHHHMGTVIESA
                     EDVDNLMKHTGEEVGLLLDTGHLTFAGADPLAVAQRWASRINHVHCKDVRADVLADVKN
                     RKTSFLDAVLSGVFTVPGDGSVNYPPIMALLKANHYQGWLVVEAEQDPAIAHPLTYARL
                     GYNNLSRFARDAGLI"
     aSDomain        complement(8248..9108)
                     /aSDomain="TIGR04379"
                     /aSTool="tigrfam"
                     /description="myo_inos_iolE: myo-inosose-2 dehydratase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_96_0004"
                     /evalue="2.00E-129"
                     /identifier="TIGR04379"
                     /label="ctg2_96"
                     /locus_tag="ctg2_96"
                     /protein_end="288"
                     /protein_start="1"
                     /score="429.3"
                     /tool="antismash"
                     /translation="TVQLGINPLTWTNDDLPSLGAETSLETCLSEGKEAGFAGFELGNK
                     FPREARLLGPVLQRHSLALVSGWYSGRLLERSVEEEIAAVQPHLTLLRELGAKVMVFAE
                     VTHCIHGEQQTPVHLRPRFPQERWAEYGKKLSEFARYTQQQGVQIAYHHHMGTVIESAE
                     DVDNLMKHTGEEVGLLLDTGHLTFAGADPLAVAQRWASRINHVHCKDVRADVLADVKNR
                     KTSFLDAVLSGVFTVPGDGSVNYPPIMALLKANHYQGWLVVEAEQDPAIAHPLTYARLG
                     YNNLSR"
     PFAM_domain     complement(8287..9018)
                     /aSDomain="AP_endonuc_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01261.26"
                     /description="Xylose isomerase-like TIM barrel"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_96_0011"
                     /evalue="1.10E-34"
                     /label="ctg2_96"
                     /locus_tag="ctg2_96"
                     /protein_end="275"
                     /protein_start="31"
                     /score="120.3"
                     /tool="antismash"
                     /translation="EGKEAGFAGFELGNKFPREARLLGPVLQRHSLALVSGWYSGRLLE
                     RSVEEEIAAVQPHLTLLRELGAKVMVFAEVTHCIHGEQQTPVHLRPRFPQERWAEYGKK
                     LSEFARYTQQQGVQIAYHHHMGTVIESAEDVDNLMKHTGEEVGLLLDTGHLTFAGADPL
                     AVAQRWASRINHVHCKDVRADVLADVKNRKTSFLDAVLSGVFTVPGDGSVNYPPIMALL
                     KANHYQGWLVVEAEQDPAIAHP"
ORIGIN
        1 agaccgccgg tatcgaactg gatatcgcca gcagcgttgc ccagctctac ttcgccatgc
       61 agaccagctt ccagaaggtg gcgctgctgc aggagctgga agctatctct cagctgtcgc
      121 tgaaggctca tgagcaccgc agcgggcgcg gggtagaaac ccgcgttgac gtcgccaacg
      181 ctcgcgccga gatgctggcc gcccagcagc aggtgatcca ggagcgcggc atgcagaccc
      241 gctatcggga aaccctgcgg gcgctaatcg gtgccgatgc gcacagcatg ccggagatcc
      301 acccagtgcc gctcccggcg ttgcagcaaa cgctgccgga taccctctca ttcgagctac
      361 tggcgcgccg cccggatctg caggccctgc gcggctacgt taccgcctcg ttaagccggg
      421 ttgatgcagc caaagcggcg ttttatccgc actttgatat caaagcgttc tggggctata
      481 acgcgctgaa cgtcggcgat ctgttcaaat attcgttcca gcagatcaac atcctgccgg
      541 gcctgtacct gccgctgttt gacggcggtc gtttgaatgc ggcgctgaag tcggtgcgta
      601 ccggcagcaa catactgatc aagcagtaca accaggcggt gctcgacgcg gtgcgcgacg
      661 tggccatcag ctcaagccag ctcaacgacc ttaaccagca ggtggcgtta cagcaggaga
      721 aagtgacggc ggcactggca acgaccaaca gcgcagcggc gcacttccag cgcgggctgg
      781 tgagctatta tgcttctcag gaggcacgtc gtccggcgct cgcccagcag ctgctgttgc
      841 tcgacatgca gtcacagcag ctcagcaccg acattacgct gattaaagcc ctcggcggtg
      901 actaccgtgg gcaggatgtg ccttctcaac cctgagcggc atacattccc gggcgttggc
      961 gctatgctaa gacgtgcaac gataataaaa gcaatatcag aggcaatgtc atgagtacgg
     1021 ataaagcatt actggaagcg ggttaccgcc agtacagcgg cgagaaaatc gacgtgtact
     1081 ttaataccga catctgccag cactcgggaa actgcgtgcg cggcagccat cagctgtttg
     1141 atttgaaacg caagccgtgg atcatgcccg atgaggtaga cgtggcgacg gtggtgaaag
     1201 tcatcgatac ctgcccgagc ggtgcgctga aatatcgaca taaataagcg agagagcgat
     1261 ggaaattctg gaaggccata acaagtttta cgttaacgat gccagtggaa accaggtcgc
     1321 ggagattgtg ttcgtgccga ccggtgagca cctgagcatt attgagcaca ccgacgttga
     1381 cccgagcctg aagggccagg gcgtcggtaa aaagctggtt gcccgcgtgg tggcgaaaat
     1441 gcgcgaagag caccgcaagg tgatcccgct gtgtccgttc gccaaacatg aatttgatac
     1501 caccccggaa tacaacgaca tccgcgcata aaaaaaaacg caccggctct caccggtgcg
     1561 taaaccctcc atggttttac gacttccttt ttcgtcccca caacacacac agagtcaggc
     1621 actcaccttc ttattgcgca tcatcagcac aacagagagt gaaattacaa tcgagataac
     1681 cagcagcacc agtacggtat ggctgaaggc ctcggtatag acactctcaa gccagctcgc
     1741 ctgttcggcg cttgcctgag cgaaagcatt tccggaaacc acatccgcca gatactgatt
     1801 cgcggtcgtc ccttccggca ccggcttcga ggccagcgcg tggaaaatcc cggtcgacat
     1861 cagcgagcca taaatggcga cggcgatggc ttcgctaccc agacggaaag tattgaggat
     1921 ccccgccgcg cgaccgacct catgggcgga caccacgctc agcgcgatcc catccaccag
     1981 accagcagaa agccccatcc cggcgcccac cagcagcagg ctcagcagaa tttgccccat
     2041 cgacatgctg ccctggttga agatccacag cagcagcaga ccaccaacaa acagcaccag
     2101 gcttatcacc agcagtaaat tagcggaaac gccgcgcgtc accagcttgc ctgcgacaat
     2161 cggtagcacc agcaccggcg aggtcagcgc cagcatcacc agcccggatt caagcggcga
     2221 gaggctcttc atggcaatca gccaggtcgg gaaccaggtc agcagcgtca cgaagcagaa
     2281 gctcgcgacc accgggataa ggatcatcga caggaaatag tggttaccga gcagcgcaaa
     2341 gttgaccatc ggattcggcg aacgtttttc taccgccacg aagcacagca gcagaaccag
     2401 gccagacccc agcagactca gggtgaagtt atcgctccag ccaagttcgg cgccctgggt
     2461 gatgccagtc atcagcagga acagcgagac gataaagagc aggatcccgg cgatatcgag
     2521 cgacggcttc tcggccttct tcaccgctgc cggaatggtg acggtcagga tcagcaccac
     2581 aaacagcgca atggcgtgga cgacgaaaat atcgcgccag cccgccacgt tcagcagcca
     2641 gccggagatg gtgggaccaa aggtgatacc cagcccggcg gtggtgccaa acagcgcaaa
     2701 cgcacgggta cgctgagcgc cgctgaaggt ttgaatgagg atggcgctac cgcaggagaa
     2761 tatcgccgca ccgccgatgc ccgccagcgc acgcgccgcg tcaagcacat agatattccc
     2821 ggcgctccac gaaagcacgg aggcaaggaa atagagcccg gcaccggcaa taaacgaacg
     2881 cttactgcca aacacgtccg caagccctcc ccaggccagg gtaaagctgg cgaaggtcag
     2941 gttaaaggcg ttgaccaccc actgcagcga ggcggtttgc gagtggagat cggcgcttat
     3001 cgccgggagg gctatcgccg tcccggaaat agacgtcggt accacgaaca ctgcaatcag
     3061 aatgcagagc aggatcatgg tttgcgatga ctttgcttca acaacttgtg tttccattat
     3121 ttaaccttat ttacggatag tacaaaccgg gagctgtgca ggtctcctga gaataattcc
     3181 ttcattccag ataaagtttt ccggtaatac gtggtctgat aaccgtaaat caggggcgag
     3241 tcgggctatt gtttttattg ccgtacagat ttccagtttt gccagttcct gccccatgca
     3301 gtgatgcatg ccatagccaa actgcagatg gcgtgggccg ttgcggaacg ggtcaatcgt
     3361 taagggagag gcgtacaccg acgggtcacg gttagcgaga aacacgtccg ggaaaatcgt
     3421 tgccccggcc gggatagtga cgccggaaag ctcgatggct tcgctacaga tgcgcggaaa
     3481 cgccgaggcg gtgccgaggt tggtcagacg aatcagttca tccgccacct gctccgtggt
     3541 ttccgggaag tccaccacct gctgccacag cgtttcagtg cacagcagcg cgtagaaaat
     3601 cttggtcatc accgtcaggg tattctggtc accccccagc agcgagccga gcagaatggc
     3661 ggtaatctct tcgtcgttta gcggcggcgt ggcgctttca cgcatcgcga caaagcgggc
     3721 aatcaggcca tcgtccgcgt gctgccgcac gccggtaacg tgctcgaaca ggtactgata
     3781 gagcgcggta aacttctcaa tgagatcttc cacctgctgc gggtcggctt tttgcaccgt
     3841 cacgctgagc acgcggaagt actctttctc caccagagga atgccgagca gcaggcagtt
     3901 aatctgcacc gccagcgggt cgagcacgtc ctgatacaga tcaaacgcct caccggcacg
     3961 ggcggcctgc atcagcgttt caatcgcgtc gaccatgtgc ggcgcaagcc acgccaggcc
     4021 gctggcgctg tagtctttcg ccacgaagcg cttcatccgc gcatggtgcg gaaagtcgag
     4081 gttcagcagt aaatccttcg gcgtcagcgt cggtaaaatg ctgggcccgt tcggctcgtt
     4141 cgacggcccg cgcaggcagg tattgctggt cagcactttt ttgacgtcgt gatagttgat
     4201 cacgtgccag gcctcgtggc cgctcagcag tttgattttg cctgcccgct ggtagctggc
     4261 gggctccagc acctcatagc ccggcgtgca gtcgtaatgc ggaatggtgg caacggatgg
     4321 ccacgcaaaa gcggtggtat tcacaggaaa acctcctgtc gttgcagcac ggcgataacc
     4381 tctgccaccg tgctggagct gtctttgaaa tgcacgctct tccagccgta ctgctcggcc
     4441 gccatgcagt tctccagaac atcatcgatc agcaggttct cgtgcgggcg cacaccagcg
     4501 cgctcggtgg cgatggcgaa gatctccgcc tccggtttac ggcaacccac tttgcaggaa
     4561 tcgacgatga catcggcctc ttcgctgatg ccaatcaccc gcttccagtg gtcttcccac
     4621 tccaccacgt tgttggtgag gatccccacc ttcagccccg tggctttgac tttgcggaac
     4681 aggtcgatca tcaactggtt aggcagaatg ccgtcgaacc actgctcgcc aaactcctcg
     4741 agccgggccc gggagagatc cagctccggg acagattgag acagcttctg gcgaattccc
     4801 gccccccatt cgcgctcggt aataatcgcc ttttcaatcg gcgtcagtac gcccatattc
     4861 aaatcgtcgg caacctcttt cattgcccgc tgtagtactg ccggggggat accggtcttc
     4921 agataataag aggtaaaaag atccggaata gacggcgaca gtacgccacc aaaatcaaac
     4981 catattattt tcatcatttt ttacttaaac gtaatagtca gttcggcccc agagaccagc
     5041 ttctcgtcct gagaaatcgt catgggaatg acggtgcttt ttttgtcatc ggtgagataa
     5101 atatcaccca gccgcgcatg gcaataaacg ggcttatgga attcacaaaa ccgtgtgaaa
     5161 ttcacgttgt agcggctaat caccaggtca aaactctgcg ttcccagacg gctacgcatc
     5221 gcgagcagcg cggtctgacg ataggcttcc atcagcagca tgcccggcac gtgatccagc
     5281 gggtggtcga aaattgacgg atgatcctgg tcgacaatca ccgtggtggt caccccgccg
     5341 tcgtgcatat ccgcattgcc caccaccacg ttttgcggca gctggcggcc cacttcgtgg
     5401 gtggcggcgg cgaaaacgga ggtggtgtcg tggcactcca gcggacgctg gctgcgcaga
     5461 cggtgccatt tgcggtcgtc catccatgaa atattcatga ttttctgcgc gcagcagtag
     5521 ccgtcgacgt agatatccat acggaaaatc agcccggtca gctcggattt gcgaaacttc
     5581 cgctcgataa tatcgacttc aacaatgacg ttagagcact cggttttgta cgggatgtca
     5641 ctgtcaaata aggtaaaatc ggcgtcatca aaaacaaatt tggcgctgta tgggacggca
     5701 aagaaattat gcgtcacgta gattgacgtt tgtcggcaaa tttccaacaa taaaatggcg
     5761 tcgtacactc gatcgctcga tttccggtac gggagatcgt taaagtaaat atgcgatttt
     5821 ggtaaataac ctgcggtgat gtatttatta tcgtggatct ttctgatatc tgttaaaaag
     5881 acttccccca ccgccgcacg atgaacacat gattttggta tggtgttctg ataattatat
     5941 gagccggtcc tgattatgaa ttctgattca acatcttcga taaaagacat gttaacccca
     6001 ttaaatcaat cattaacctc aggattaggg ttatctcact cactcgtagt aagataaccg
     6061 ttaatcgttc gcctcacatc gtacgtatca ccccacgcgt acgttcgatg atcatcgaac
     6121 acctattaaa attcaggatt cctggacttt tgtcaagaat ctgttaagag aaatctgtaa
     6181 atcaggagaa agaatggaag aaaaggtcgc cgaagaggca gttccctttg atatggttaa
     6241 ggttttcaaa gctcttgccg acccagtgag gctaacgatt gtgcgtggat tgctggctga
     6301 caagcctgga gccgaacgac attgttccac ttttgggctc accgtcacac gagcgactcg
     6361 ctcccatcac ttcaaagtgc tacgtgaagc cggtctgatc cgtgtggtcg acaagggcaa
     6421 tatggccgtc gccgtgttac gttgggacga gattgagaac gaccttccgg gcctggtgaa
     6481 gctcattcgc cacacggata aataaccaaa aatagtgcta tgaagtaccg aaatatatac
     6541 gcctgaagac ctgttaaaat agtaataata acgttttcag tggtataaac ttccggctgt
     6601 tccgcttagt tcagccggaa gttccttcct tatttttcat ttttttgcgc cgtgagaata
     6661 atacgcgata gccctcacac cctttcacat tagttactat tatgatttga cagaataatt
     6721 cgcgcagaga gaaagctgat ggaccctttc cacgccatag tgctgaccgt tggactgttt
     6781 gttttgacct tttttaaccc cggcgccaat ctgtttgtgg tggtacaaac cagcctcgct
     6841 tccggacgac gggcgggggt gatcaccggg cttggcgtcg cgctcggcga tgcgctctat
     6901 tccggattag gcctgtttgg catggcaacg ctcatcaccc agtgtgaaag cctgttttcc
     6961 gctatcaaga ttgtcggcgg cgcgtatctg ctgtggtttg cgtggaaaag cctgcgtcgc
     7021 cagcctacgc cgatgtcctc cgccctgctg cagcccattg tggcaccatg gcatgtgttc
     7081 tttcgcaccg gagcgatcac ctgcctctcc aatccgcaga cggtgctgtt tttcatcagt
     7141 attttctcgg tgaccttaag cgcgcagacg cccacctggg caaaactgct ggcgtggtgt
     7201 gggatagtcc tgagctcggt aatctggcgg gtattcctga gccaggcgtt ttcgctgccg
     7261 gcggtacgcc gtggctatgc gcggacgcag aaagtcgcca gccgggtgat tggggtggtg
     7321 atcggcgcgt ttgccgtgaa gctcatctgg gaaggggtaa tgcgtaagta gccgatcctt
     7381 ccgtggatcg gcgcttcttc aggcagggta atcgcggttg atccaggcgt gatcctcttc
     7441 ccaggtgaac atccattggc gcaccgggcc tgccatcacg ttgaggtaat agctgtcata
     7501 ccccgccatc gtcgccaccg ggtgatagcc ttttggcacc atcaccacgt cacgatcgta
     7561 caccgccata cactcgtcca gctcccggtc gtcggtatac acccgctgca tacaaaaacc
     7621 ctgcggcggg ttgagacggt gataataggt ctcttcgagg tacgtttcct gcggcgggtt
     7681 atcggtgtcg tgcttgtggc ttggataaga gctggtgcag ccttcgttgg tccacacttc
     7741 caccaccagc aggctgtcag cgggtttatc ttccggcaga atgttgtgca cgtagcgctg
     7801 attatgcccc ttgccgcgcg cttcgccgtc gatatcctgc ggcgcaatca ggcgcgttgg
     7861 ccagttgcct ttgcccggcg cggcgcacac cgccagctca agtttcgtca gcgcctgcac
     7921 ctgtatgctt tcgcccggcg tcacgtacac cgcccagggt ttgatgcgct cgaacggact
     7981 catgcgctcg ccgatgtcgg aaaactgcgc cgttggggta ccgatggagg cgcggcctgc
     8041 aaccagcacc agacagcgct cctcgctggc cgcgggcagc gtcagccgct gtccctcttc
     8101 cagttggtat gcttcaaacc ccacatagcc ccagcccgca cgagcgggtg tcaccgcctg
     8161 ggtgcggcca ctggcatccg gtttttgcca gcgtgagagt aaacgcgaca tgtttcctcc
     8221 tcagattagc ccggcatcac gggcgaagcg gctcaggttg ttgtagccca gacgcgcgta
     8281 ggtcagcgga tgggcgatag ccggatcctg ctcggcctcc accaccagcc agccctgata
     8341 atggttagct ttaagcagtg ccataatcgg cgggtagttc acgctgccgt cgcccggtac
     8401 ggtaaacacg ccgctcagca ccgcgtcgag gaagctggtt ttgcggttct tcacgtccgc
     8461 cagcacgtcg gcacgtacgt ctttgcagtg aacgtggtta atacgtgaag cccagcgctg
     8521 cgctaccgcc agcggatctg ccccggcaaa ggtcaggtgc ccggtatcca gcagcagacc
     8581 cacctcttcc ccggtatgtt tcatcagatt atccacatct tcggcggatt caatcaccgt
     8641 ccccatatgg tgatgatagg caatctgcac gccctgctgt tgggtatagc gggcaaactc
     8701 gctgagcttt ttgccatatt cggcccagcg ttcctgcggg aagcgcgggc gtaaatgcac
     8761 cggcgtttgc tgctcgccgt gaatgcagtg ggtcacttcg gcaaatacca tgaccttcgc
     8821 ccccagctca cgcagcagag tcagatgcgg ctgcacggcg gcaatctctt cttcgacgct
     8881 gcgctccagc aggcgcccgg agtaccagcc ggacaccagc gccagggaat gacgctggag
     8941 aacagggccc agcaggcggg cttcgcgcgg gaacttgttc cccagttcaa agccggcaaa
     9001 accagcctct ttaccttcgc tgagacaggt ttccagcgac gtttcagcgc cgagtgacgg
     9061 gaggtcatcg ttggtccagg tcagcggatt aatacccaat tgtacggtca tcgtattctc
     9121 ctgaattatg cgttcccgcg ctcgcgccac caggcgataa gctgcaggta gttgtcccga
     9181 atgcgcgcca ccagctgcgc gtcgtcaata tcgtgtttca gccaggcgcg ggacgcatca
     9241 ccaaacagcg tccgccccac ggcaaaccct ttcaccagcg catgaccgga agcggccttg
     9301 aagccagcac gcagctgctc tgccggtgca tccagcccca gaatgaccac cccgcggcag
     9361 tgcggatccc ggcgctcgat aatctcgcca agctgcgccc agcccccgga ggagagcggc
     9421 ggcagcttcc accagtccgg gtagatgccg atgttgtaaa agcgcgatac cgcccgcagg
     9481 tacagctcgt cgctgcgcgg catgtcggcg gggaggatca cctccagcag cagctcatgg
     9541 ccggactgac agcaagcgtg gtacacctcg gcgacctttt gctcctgctc cagacgcaga
     9601 ccatgggcat cttccgggtg gaaaaagacc aggcacttca ccacatgctc cagcggccag
     9661 ctgatgagct gcgtgccgat gttgccgcgc tccatctcca gcggacgcga accgggcagt
     9721 tctaccgggc ggccaatcca ccagccttcg ccggtgatgg cgttgagcgc gtcctggccg
     9781 aaggtgccgt cacacagcag cccggcttta ccttccagcc ccgcgcgatc tgctgcctct
     9841 cggcttgcct gcaggatcag cgtttttaat tgaggaatgc gtttgaaatc agccccgcac
     9901 tgcagcgcca tctcttccag ctggctgcgg tgatcgaagg ccatcacgca cagttctggc
     9961 cactcgcggc gacgggtggt gacccggtgc agatggttca gacgagcgtc aagatccggg
    10021 cgcggtactt ctgcctcgcg ggagagatag tcgtccagct ctactttgct cggcatcgcc
    10081 ggggcgcagc cgtggcgtga caccaccagc gccccgcagg cgttggcgta gcggcaggcc
    10141 tgctcccagc cttcatcgct aagatagccg cgcagcaggc cggacataaa cgcatctccg
    10201 gcccccagca cgttcagcac ttcgacacgc acgccggtga cgttaagggc gccgtcgagg
    10261 tgcgatggga tcggcccttc gtacaccgag cagccccgcg ccccgcgctt gcagacgagc
    10321 gttgccccgc tcacttcacg cacgtgctgc agcgccgtta aggtgtcggt gctgccgccg
    10381 gcgatgtgaa actcctcttc ggtgccaaca atcacatcaa agagactcag caccgcctgt
    10441 agctcgcggg taacctgttc ggcggcgata aagcgcgttt cgccatcgcc gggtgaggtg
    10501 agcccccaca gcaccggacg gtagtcgata tcgagcagcg tgcgcacacc gtggcgtcgg
    10561 gcatagccaa gcgccgtcag caccgcctcg cgggtttgtg gatgagaaag gtgggtcccg
    10621 gtgatggcca gacttcgtga agcggcgatg tactgttcgt cgacgtcggc ggcggtaatc
    10681 gccatgtcgg cacagttatc gcgataaaaa atcagtggga aggtgtcccg gtctttaatg
    10741 ccgagtagca ccagcgccgt gaggcgcgat ttatcggtta tcagatggct ggtatcacaa
    10801 ccaacctggt taagttcttc gcgcagaaag cgccccatat gctcgtcgcc aacccgcgcc
    10861 agcattgacg agcgcagccc ctggcgcgcc gtgccgtagg cgacgttgcc ggacgagccg
    10921 ccgaggtatt tggcaaagct cgacgcatct tccagacgcg cgccaatctg ctgactgtag
    10981 agatcaaccg
//
