LOCUS       c00079_NZ_JMTB..       10402 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JMTB01000080.1 Trabulsiella guamensis ATCC 49490
            GTGU.assembly.080, whole genome shotgun sequence.
ACCESSION   NZ_JMTB01000080
VERSION     NZ_JMTB01000080
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:51:23
            Original ID  :: NZ_JMTB01000080.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1315
            Orig. end    :: 11717
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10402
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[6315:6717](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5402)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     cand_cluster    1..10402
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10402
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="1"
                     /rules="AfsA"
                     /tool="antismash"
     CDS             1013..1243
                     /locus_tag="ctg79_4"
                     /transl_table=11
                     /translation="MDKELEDAGYRVYHGEKIDVYFNTAICQHSGNCVRGSHQLFNLKR
                     KPWIMPDEVGVDTVVSVIDTCPSGALQYRHK"
     PFAM_domain     1049..1240
                     /aSDomain="Fer4_19"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06902.13"
                     /description="Divergent 4Fe-4S mono-cluster"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_4_0001"
                     /evalue="2.60E-27"
                     /label="ctg79_4"
                     /locus_tag="ctg79_4"
                     /protein_end="76"
                     /protein_start="12"
                     /score="94.8"
                     /tool="antismash"
                     /translation="YHGEKIDVYFNTAICQHSGNCVRGSHQLFNLKRKPWIMPDEVGVD
                     TVVSVIDTCPSGALQYRHK"
     CDS             1255..1527
                     /locus_tag="ctg79_5"
                     /transl_table=11
                     /translation="MEILEGHNKFYVNDAQGQQVAEIVFVPTGENLSIIEHTDVDPSLK
                     GQGVGKQLVARVVEKMRQENRKIIPLCPFAKHEFDKTREYDDIRA"
     PFAM_domain     1279..1518
                     /aSDomain="Acetyltransf_CG"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14542.8"
                     /description="GCN5-related N-acetyl-transferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_5_0002"
                     /evalue="1.50E-22"
                     /label="ctg79_5"
                     /locus_tag="ctg79_5"
                     /protein_end="88"
                     /protein_start="8"
                     /score="79.6"
                     /tool="antismash"
                     /translation="KFYVNDAQGQQVAEIVFVPTGENLSIIEHTDVDPSLKGQGVGKQL
                     VARVVEKMRQENRKIIPLCPFAKHEFDKTREYDDI"
     CDS             complement(1610..3112)
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 297.4; E-value:
                     2.3e-90)"
                     /gene_kind="transport"
                     /locus_tag="ctg79_6"
                     /transl_table=11
                     /translation="METHVVEAKSSHSMILLCILIAVFVVPTSISGTAIALPAISADLH
                     SQTASLQWVVNAFNLTFASFTLAWGGLADVFGSKRSFIAGASLYFLASLLSWHADNIYV
                     LDAARALAGIGGAAIFSCGSAILIQTFSGAQRTRAFALFGTTAGLGITFGPTISGWLLS
                     VAGWRDIFIVHAIALFVVLLLTSAVPAAAKRTEKPSLDAAGIVLFIVALFLLMTGITQG
                     AERGWTDNLTLGLFAVGVVILALFVLVEKKAAHPMVNFSLLGNHYFLSMIMIPVVASFC
                     FVTLLTWFPTWLIAVKSLSPFDSGLVMLALTTPVLVLPLVAGKLVTRGVSADVLLITSL
                     VLFIVGLLLLWAFNAGDISLGEIILCLLLVGSGMGLSAGLVDGIALSVVDQHEVGRAAG
                     ILNTFRLGSEAIAVAIYGSLMATGIFHALGSQPMPAGESGKQFIADVVSGNAFARVSGQ
                     ESSILENIYTQAFSHTLLVLLAISLVASLFIVLMMRNKAAKA"
     PFAM_domain     complement(1892..3058)
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_6_0003"
                     /evalue="2.00E-45"
                     /label="ctg79_6"
                     /locus_tag="ctg79_6"
                     /protein_end="407"
                     /protein_start="18"
                     /score="155.3"
                     /tool="antismash"
                     /translation="ILIAVFVVPTSISGTAIALPAISADLHSQTASLQWVVNAFNLTFA
                     SFTLAWGGLADVFGSKRSFIAGASLYFLASLLSWHADNIYVLDAARALAGIGGAAIFSC
                     GSAILIQTFSGAQRTRAFALFGTTAGLGITFGPTISGWLLSVAGWRDIFIVHAIALFVV
                     LLLTSAVPAAAKRTEKPSLDAAGIVLFIVALFLLMTGITQGAERGWTDNLTLGLFAVGV
                     VILALFVLVEKKAAHPMVNFSLLGNHYFLSMIMIPVVASFCFVTLLTWFPTWLIAVKSL
                     SPFDSGLVMLALTTPVLVLPLVAGKLVTRGVSADVLLITSLVLFIVGLLLLWAFNAGDI
                     SLGEIILCLLLVGSGMGLSAGLVDGIALSVVDQHEVGRAAGILNTFRLG"
     CDS             complement(3112..4344)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 256.7; E-value: 6.1e-78)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg79_7"
                     /sec_met_domain="p450 (E-value: 1.4e-16, bitscore: 51.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSVISERFPSVADIPHYDCTPGYQTLQPATYQQAGKIKLLSGHEA
                     WHVINYHDVKKVLTSNSCLRGPSNLPDAPSILPTLTPKDLLLNLDFPHHARMKRFVAKD
                     YSASGLAWLAPHIIDVIETLMQRPLATSRFDLYQDVLDPLAVRINCLLLGIPLEEKDYF
                     RVLSVTVQKANPQQVDDLIEKFTALYTYVREHVTGVRSHHDEGLIARFVAMRDSATPPL
                     NDDEITAILLGSLLGGDQNTLTVMTKIFYALLCTGSLWQQVVAQPATIPQVVDELIRLT
                     NLGTASAFPRICSEDIELSGQRIPAGDTIFPDVFLANRDPDVYPQPLTINPFRNGPRHL
                     QFGYGMHHCMGQELAKLEICTAIKTISQLAPDLQLAHDVLPENFIWNEGIILRRPAQLP
                     VCITRKQGSIK"
     PFAM_domain     complement(3247..3771)
                     /aSDomain="p450"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00067.24"
                     /description="Cytochrome P450"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_7_0004"
                     /evalue="9.30E-15"
                     /label="ctg79_7"
                     /locus_tag="ctg79_7"
                     /protein_end="366"
                     /protein_start="191"
                     /score="54.4"
                     /tool="antismash"
                     /translation="VREHVTGVRSHHDEGLIARFVAMRDSATPPLNDDEITAILLGSLL
                     GGDQNTLTVMTKIFYALLCTGSLWQQVVAQPATIPQVVDELIRLTNLGTASAFPRICSE
                     DIELSGQRIPAGDTIFPDVFLANRDPDVYPQPLTINPFRNGPRHLQFGYGMHHCMGQEL
                     AKLEICTAIKTI"
     CDS             complement(4341..4994)
                     /locus_tag="ctg79_8"
                     /transl_table=11
                     /translation="MKIIWFDFGGVLSPSIPDLFTSYYLKTGIPPAILQRGMKEVADDM
                     NMGVLTPIEKALITEAEWGARIRQKIALSSPELDLSRAQLEMFGAQWFDGILPNQLMID
                     LFLKVKAAGLMAGILTNNVVEWEDHWKRVIGISDLADAIVDSCKVGYRKPEAEIFDIAA
                     KQAGVRPDECLLIDDMLENCMAAERSGWRSVHFKESSSVVAEIAQLLQKQEIAL"
     aSDomain        complement(4410..4601)
                     /aSDomain="TIGR01509"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IA-v3: HAD hydrolase, family IA,
                     variant 3"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg79_8_0001"
                     /evalue="3.40E-13"
                     /identifier="TIGR01509"
                     /label="ctg79_8"
                     /locus_tag="ctg79_8"
                     /protein_end="195"
                     /protein_start="131"
                     /score="48.0"
                     /tool="antismash"
                     /translation="RVIGISDLADAIVDSCKVGYRKPEAEIFDIAAKQAGVRPDECLLI
                     DDMLENCMAAERSGWRSVH"
     PFAM_domain     complement(4413..4691)
                     /aSDomain="HAD_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13419.8"
                     /description="Haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_8_0005"
                     /evalue="5.50E-09"
                     /label="ctg79_8"
                     /locus_tag="ctg79_8"
                     /protein_end="194"
                     /protein_start="101"
                     /score="36.5"
                     /tool="antismash"
                     /translation="MIDLFLKVKAAGLMAGILTNNVVEWEDHWKRVIGISDLADAIVDS
                     CKVGYRKPEAEIFDIAAKQAGVRPDECLLIDDMLENCMAAERSGWRSV"
     CDS             complement(5001..5402)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_9"
                     /sec_met_domain="AfsA (E-value: 1.3e-18, bitscore: 58.4,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEVGRQLPLNVVIGNADIHDSGITTTVIVDQTHPSIFDHPLDHV
                     PGMLLMEAYRQTALLAMRSRLGTRCYDLVISRYKVNFTRFCEFNSPAYCHALLGEIYLT
                     EDKKSTVIPMTISQDEKTVSMAELTITFK"
     PFAM_domain     complement(5010..5393)
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_9_0006"
                     /evalue="2.10E-19"
                     /label="ctg79_9"
                     /locus_tag="ctg79_9"
                     /protein_end="131"
                     /protein_start="3"
                     /score="69.9"
                     /tool="antismash"
                     /translation="VGRQLPLNVVIGNADIHDSGITTTVIVDQTHPSIFDHPLDHVPGM
                     LLMEAYRQTALLAMRSRLGTRCYDLVISRYKVNFTRFCEFNSPAYCHALLGEIYLTEDK
                     KSTVIPMTISQDEKTVSMAELTIT"
     CDS             complement(5558..5764)
                     /locus_tag="ctg79_10"
                     /transl_table=11
                     /translation="MTRSCYWKFAVRPRFMSHIIFSPFRTAPNLSLMTPISPFLKVKYL
                     TKQSAQTSLLKSILLSASSENQS"
     CDS             complement(5954..6124)
                     /locus_tag="ctg79_11"
                     /transl_table=11
                     /translation="MCSMSIERTRGVIRTMCGERLMVILLRLSEITLILRLMIDLMGLT
                     CLSSKMLNQNS"
     CDS             complement(6361..6492)
                     /locus_tag="ctg79_12"
                     /transl_table=11
                     /translation="MTNKLNQAWKLVFNFIPPQYGDGHITLVNDADQPRFTQHFEVM"
     CDS             6758..7390
                     /gene_functions="transport (smcogs)
                     SMCOG1116:Homoserine/threonine efflux protein (Score:
                     125.7; E-value: 3.1e-38)"
                     /gene_kind="transport"
                     /locus_tag="ctg79_13"
                     /transl_table=11
                     /translation="MDPLHAILLTVGLFVLTFFNPGANLFVVVQTSLAAGRRAGVLTGL
                     GVALGDALYSGLGLFGMATLITQCEGLFSAIKIGGGLYLLWFAFKSMRRQPSPMTPALA
                     HPIVAPWYVFFRTGMITCLSNPQTVLFFISIFSVTLSATTPAWAKLLAWLGIVLSSVTW
                     RLFLSQAFSLPAVRRSYASMQRIASRVIGAVIGLFAVKLIWEGVMRK"
     PFAM_domain     6806..7372
                     /aSDomain="LysE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01810.20"
                     /description="LysE type translocator"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_13_0007"
                     /evalue="6.50E-47"
                     /label="ctg79_13"
                     /locus_tag="ctg79_13"
                     /protein_end="205"
                     /protein_start="16"
                     /score="159.6"
                     /tool="antismash"
                     /translation="TFFNPGANLFVVVQTSLAAGRRAGVLTGLGVALGDALYSGLGLFG
                     MATLITQCEGLFSAIKIGGGLYLLWFAFKSMRRQPSPMTPALAHPIVAPWYVFFRTGMI
                     TCLSNPQTVLFFISIFSVTLSATTPAWAKLLAWLGIVLSSVTWRLFLSQAFSLPAVRRS
                     YASMQRIASRVIGAVIGLFAVKLIWE"
     aSDomain        6815..7363
                     /aSDomain="TIGR00949"
                     /aSTool="tigrfam"
                     /description="2A76: homoserine/Threonine efflux protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg79_13_0002"
                     /evalue="9.80E-62"
                     /identifier="TIGR00949"
                     /label="ctg79_13"
                     /locus_tag="ctg79_13"
                     /protein_end="202"
                     /protein_start="19"
                     /score="205.9"
                     /tool="antismash"
                     /translation="NPGANLFVVVQTSLAAGRRAGVLTGLGVALGDALYSGLGLFGMAT
                     LITQCEGLFSAIKIGGGLYLLWFAFKSMRRQPSPMTPALAHPIVAPWYVFFRTGMITCL
                     SNPQTVLFFISIFSVTLSATTPAWAKLLAWLGIVLSSVTWRLFLSQAFSLPAVRRSYAS
                     MQRIASRVIGAVIGLFAVKL"
     CDS             7700..9154
                     /gene_functions="other (smcogs) SMCOG1061:methyl-accepting
                     chemotaxis protein (Score: 366.7; E-value: 3.8e-111)"
                     /gene_kind="other"
                     /locus_tag="ctg79_14"
                     /transl_table=11
                     /translation="VAIRFLKNQRDPASLEAINKLLNTAGDSLNKAENYYKSWQGLPPV
                     VGQSATLTVEMDKTFRQMHDVLRQSIDYLRADNYQAYGDLDAQQAQDDMEASYNRWRAE
                     NNMLLKGAAEDNQRSFVNMHWTLGVILVSVITVLIVIWLGLQHLLLKPLRSIMNHIRTI
                     ARGDLTQTIAINSRNEMGQLAASLNEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSHDL
                     SSRTEQQASSLEETAASMEQLTATVKQNTDNARQATLLAKTASETAARGGRVVDTVVHT
                     MSEIADSSQQIAHITSVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLASR
                     SAQAAKEIKGLIDNSVSRVNTGSSQVTEAGNTMKELVEAVTRVTDIMSEIASASDEQSR
                     GIEQVSLAVAQMDSVTQQNAALVQESAAAAAALEDQAEQLRQAVAAFRLNGSSTFDAKP
                     AAAVKTPVLLRPATVAPGSDSNWETF"
     PFAM_domain     7703..8014
                     /aSDomain="TarH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02203.17"
                     /description="Tar ligand binding domain homologue"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_14_0008"
                     /evalue="3.20E-18"
                     /label="ctg79_14"
                     /locus_tag="ctg79_14"
                     /protein_end="105"
                     /protein_start="1"
                     /score="66.4"
                     /tool="antismash"
                     /translation="AIRFLKNQRDPASLEAINKLLNTAGDSLNKAENYYKSWQGLPPVV
                     GQSATLTVEMDKTFRQMHDVLRQSIDYLRADNYQAYGDLDAQQAQDDMEASYNRWRAEN
                     "
     PFAM_domain     8141..8284
                     /aSDomain="HAMP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00672.27"
                     /description="HAMP domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_14_0009"
                     /evalue="3.20E-14"
                     /label="ctg79_14"
                     /locus_tag="ctg79_14"
                     /protein_end="195"
                     /protein_start="147"
                     /score="53.1"
                     /tool="antismash"
                     /translation="LLLKPLRSIMNHIRTIARGDLTQTIAINSRNEMGQLAASLNEMQQ
                     SLV"
     PFAM_domain     8477..8944
                     /aSDomain="MCPsignal"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00015.23"
                     /description="Methyl-accepting chemotaxis protein (MCP)
                     signalling domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg79_14_0010"
                     /evalue="3.10E-57"
                     /label="ctg79_14"
                     /locus_tag="ctg79_14"
                     /protein_end="415"
                     /protein_start="259"
                     /score="193.2"
                     /tool="antismash"
                     /translation="LAKTASETAARGGRVVDTVVHTMSEIADSSQQIAHITSVIDSIAF
                     QTNILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIDNSVSRVNTGS
                     SQVTEAGNTMKELVEAVTRVTDIMSEIASASDEQSRGIEQVSLAVAQMDSVT"
ORIGIN
        1 taatcagtgt gtcagcgccc atttttgccg ccagcgacag cgagcgcgag ctgacatcgg
       61 cgcagacaat ttccgccgca ccgagcgttt ttactgcgct gataatcagg cagccaatcg
      121 ggccgacgcc ggaaataaag acccgtttgc cctgtaaatc accggcttcg tgcgccgcat
      181 ggatcgccac cgccagcggt tcagcgaaag ccattacttt ttcatcggca tttgacgaga
      241 acggaataca ctgggcggta tccaccactt tgtaacgggt aaacccgcca tcgacgtgcg
      301 gaaagtacat cgcgctgcca aagaaacgca tttccgtaca ctggttttct tcatgctgca
      361 gacaatattt acagtggcca cacggtttcg atggattcac tgcgacagcc tgcccttctt
      421 ttaattctgt ggaatcggta tgaacaattt taccaataac ttcatggcca agaatcatcg
      481 gcgcttttac ggtgaaatta ccgactttac cttcctgata ataatgtaaa tcggaaccac
      541 aaataccgcc tcgcgttatt tgcacaagcg ttcctttatt attccattct atttcctggt
      601 cgctaacggc aacagttttc ttgcccgcga caacgcagga ttgtgtttta accttcatat
      661 gttcctcact ggtcaggcat taacctcagc ggcatttaaa cggttttata tgcgccgatt
      721 cgtgagcaaa gtcacattaa aaaattgtta caccacaatg ttacgcataa cgtgataagc
      781 ctttaacttc ttcttgctga tcgtaaaagt ggttgaaagt gatattttga cgagcgtcat
      841 gtagcaaaaa acgaaaccgg ttttattatt gaaaataaca atatctcgat atttttgtac
      901 aatcgctgtt gctgttttaa gacggaacag aacaattccg gttcactact ctggcaagaa
      961 aaaggctatg cttattgttg caaagaacag aagtgcattc agaggtcatg tcatggataa
     1021 ggaacttgag gacgcaggct accgggttta tcacggtgag aagattgacg tctatttcaa
     1081 caccgccatc tgccagcatt caggcaactg cgtgcgcggc agtcatcagt tgtttaatct
     1141 taagcgtaaa ccgtggatca tgccggatga agtcggggtg gatactgtgg tgagcgtgat
     1201 tgatacctgc cccagcggcg cactgcaata tcggcataaa taagcgagaa gatgatggaa
     1261 atactggaag gtcacaacaa attctatgtc aacgatgcgc aaggccaaca ggtggctgag
     1321 atcgttttcg tcccgacggg cgagaatctg agcattattg aacataccga cgtcgatccg
     1381 agcctcaaag ggcaaggcgt gggcaaacaa ctggttgccc gtgtggtcga aaaaatgcgt
     1441 caggagaacc gtaaaatcat tccgctttgc ccgttcgcga agcatgaatt tgataaaacc
     1501 cgcgaatacg acgacatccg cgcctaaaaa aacgcaccgg ttctcacacc ggtgcgcaat
     1561 tcatccctga aacgatactt ccctctaccg tccccacaac agcaaaatgt tatgctttcg
     1621 ccgccttatt gcgcatcatc agcacgataa acagcgaggc gaccagggag attgccagca
     1681 acactaacaa cgtgtggctg aatgcctggg tatagatgtt ttccagaatc gaggattcct
     1741 ggccggagac gcgggcgaag gcgttgcccg acaccacgtc agcaataaat tgtttgcccg
     1801 attcccctgc aggcatcggt tgcgatccca gcgcgtggaa aatcccggtg gccattagcg
     1861 aaccgtaaat cgcgacggca atcgcttcac tgcccaggcg gaaggtgttc agaatgcccg
     1921 ccgcgcgacc cacttcgtgt tgatcaacga cgctcaatgc gatgccgtcc accagcccgg
     1981 cggaaagccc catcccggaa ccaaccagca acagacagag gatgatttcg ccaagcgaga
     2041 tatcacctgc gttaaacgcc caaagcaaca gcaggccgac gatgaacagc accagactgg
     2101 taatcagcag tacgtcggca gagacgccac gcgtaaccag cttcccggcc accagcggca
     2161 gtaccagaac cggcgtggtg agcgccagca tcaccagccc ggaatcaaac ggagacaggc
     2221 ttttcacagc gataagccag gtcgggaacc aggttagcag ggtgacgaaa cagaagctcg
     2281 ccaccaccgg aatcatgatc atcgacagaa aatagtggtt gcccagcagg gagaaattca
     2341 ccatcgggtg agcggctttt ttctccacca gcacaaacag cgccaggatc accacgccaa
     2401 cggcaaacag accgagggtc aggttatccg tccagccgcg ctccgcgccc tgggtgatac
     2461 cggtcatcaa caggaacagc gccacgataa acagcacaat gcctgccgca tcaagcgatg
     2521 gtttttccgt acgctttgcc gccgccggta cggcgctggt caacagcagc accacaaaca
     2581 gtgcaatcgc atggacgatg aaaatatcgc gccacccggc gacactcagc aaccagccag
     2641 agatggttgg cccgaaggtg atgcctaacc cggcggtggt gccaaacagc gcaaacgcgc
     2701 gggtgcgctg tgcaccgctg aaggtctgaa tcagaatggc gctgccgcag gagaaaatgg
     2761 cagcgccacc aatgccggcc agcgcgcgtg cggcatccag cacgtaaatg ttatcggcat
     2821 gccaggagag caaagaagca aggaaataga gactcgcccc ggcgataaac gagcgcttgc
     2881 taccgaacac atcggccagc ccaccccacg ccagtgtgaa actggcaaag gttaagttaa
     2941 acgcattgac cacccactgc agcgacgccg tctgcgaatg gagatccgcg ctgatcgccg
     3001 gcagcgcaat agccgtcccg gaaatagagg ttggcacaac gaacactgca ataagaatgc
     3061 agagtaagat catgctatgc gatgattttg cttcgacaac gtgtgtttcc attattttat
     3121 tgagccttgt ttacgggtaa tacaaaccgg gagctgtgca ggtctcctga gaataatgcc
     3181 ttcattccag ataaagtttt ccggtaatac gtcgtgggct aactgcagat ccggcgcaag
     3241 ctggcttatg gtttttattg ccgtgcagat ttccagtttc gccagttcct gtcccataca
     3301 gtggtgcatg ccatagccaa actgcagatg gcgcggcccg ttgcggaacg ggttaatggt
     3361 cagcggttgc ggatagacat ccgggtcgcg gttagcgaga aacacgtccg ggaaaatggt
     3421 gtctcctgct ggaatacgct ggccagacag ttcgatgtcc tcgctacaga tgcgcggaaa
     3481 cgccgaggcg gtgccgaggt tagtgaggcg aatcagctca tccacgacct gtggaatggt
     3541 cgccggttgc gcgacaacct gttgccacag cgaacccgta cacagcaggg cgtaaaaaat
     3601 tttggtcatc accgtgaggg tgttttgatc gccaccgagc agcgaaccga gcaggatcgc
     3661 ggtgatctca tcgtcgttga gcggcggcgt ggcgctgtcg cgcatcgcca caaaacgggc
     3721 gatcagcccc tcgtcatgat gtgaacgcac gccggtgaca tgctcgcgaa cataggtgta
     3781 gagcgcggtg aatttctcaa tcagatcatc cacctgctgc ggattggctt tttgcaccgt
     3841 cacgctcagc acgcggaaat agtctttctc ctccagtgga ataccgagca gcagacagtt
     3901 gatccgcacc gccagcgggt cgagcacatc ctgataaagg tcgaaacgtg acgtggcaag
     3961 cgggcgctgc atcaaggttt caatgacatc gataatatgc ggcgcaagcc aagccagccc
     4021 gctggcgctg taatctttcg ccacaaaacg cttcatgcgg gcatgatgcg gaaaatccag
     4081 gttcagcagc agatctttcg gcgtcagcgt cgggagaata ctgggggcat cggggagatt
     4141 ggacgggccg cgcaggcaac tgttactggt gaggactttt ttgacatcgt gatagttaat
     4201 cacatgccag gcttcatgcc cgctcagcaa tttgattttc cctgcctgct gatacgtcgc
     4261 aggttgcagc gtctgataac cgggagtgca atcgtaatgc ggaatgtcgg caacggacgg
     4321 gaaacgttca gatatcacgc tcacagggca atctcctgtt tctgtagcag ttgggcgatc
     4381 tccgccacca cgcttgaact ctctttaaaa tgcacgcttc gccagccact gcgttcagcg
     4441 gccatgcagt tttccagcat gtcatcaatg agcaggcact cgtccgggcg gacacccgcc
     4501 tgttttgcgg cgatgtcaaa gatttccgct tcgggtttgc ggtagcccac tttgcaggag
     4561 tcgactatcg catccgcgag gtcactgatg ccgatcaccc gcttccagtg atcttcccac
     4621 tccaccacgt tgttggtgag gatcccggcc atcaacccgg cagcttttac tttgagaaac
     4681 aagtcgatca tcaattgatt cggtagtatc ccgtcgaacc actgcgcacc gaacatttcc
     4741 agttgtgccc gcgagagatc gagctccggc gacgacagcg caattttctg ccggatacgc
     4801 gcgccccatt cggcctcggt aatcagcgct ttttcgatgg gggtgagcac ccccatattc
     4861 atatcgtcgg cgacctcttt catcccccgc tgcaatatcg ctggcggaat accggttttc
     4921 aggtaatacg aggtaaagag atccggaatc gatggtgaca gcacgccccc aaaatcaaac
     4981 caaataattt tcatactgtt ttacttaaag gtaatagtga gttcagccat tgagactgtc
     5041 ttctcgtcct gagaaatcgt catcggaatg acggtgcttt ttttatcttc cgtcagataa
     5101 atttcaccca gcaatgcatg gcaatacgcc ggcgaattaa attcgcagaa gcgggtaaaa
     5161 ttcactttat agcggctgat gaccagatcg taacagcggg ttcccagccg actgcgcatc
     5221 gccagcagtg cagtctgacg gtaggcttcc attaacagca tgcccggcac atggtcgagc
     5281 ggatggtcaa aaatggacgg gtgcgtctga tcgacgatca ccgtcgtggt aatgccagaa
     5341 tcatggatat ccgcattgcc gataaccaca ttcagcggca gttgacgccc gacttccagc
     5401 atttctgcgg gtacaaccgt ggaataatcg tgattgtcca gcggacgctg actacgcaga
     5461 cggtgccatt ttttgtcatc catccacgaa atattcatga ttttctgcgc acagcacaga
     5521 ccatcgacat aaatatccat acggaaaata agaccggtca gctctgattt tctgaacttg
     5581 cgctcaataa tatcgacttc aacaatgacg tttgagcact ctgttttgta aggtatttca
     5641 ctttcaaaaa gggtgaaatc ggcgtcatca aagacaaatt tggcgctgta cggaacggcg
     5701 aaaaaattat gtgtgacata aatcgaggtc tgacggcaaa tttccagtaa caggatcgcg
     5761 tcatacactc gttcactcga ttttcgaaaa gggagatcgt taaagtaaat atgtgatttg
     5821 ggtaaatacc cggcggttat gtatttatta tcgtggattt ttctgatgtc tgttaaaaag
     5881 acttcgccca ctgccgcacg atgcacacaa gatttcggta tggtgttctg ataattatat
     5941 gaaccggtcc tgattatgaa ttctgattca acatcttcga tgaaagacat gttaacccca
     6001 ttaaatcaat cattaatctc aggattaggg ttatctcact gagtcgtagt aagataacca
     6061 ttaatcgttc gccacacatc gtacgtatca ccccacgcgt acgttcgata ctcatcgaac
     6121 acatataaaa ttcaggattc ctggaaattt gtcaagaatc tgttaagaga aatctgtaaa
     6181 tcaggagaaa gaatggaaga aaaggtaagt gaagagtcgt taccctttga tatggttaaa
     6241 gtatttaaag cgctggctga tcctgtccgt ttgacgattg tgcggggttt gctggctgac
     6301 agcccaggag cggagcgtca ctgctccaca tttgggctca ccgtcacgcg cgccactcgc
     6361 tcacatcact tcaaagtgct gcgtgaagcg gggctgatcc gcgtcgttga caagggtaat
     6421 atggccgtcg ccgtactgcg gtgggatgaa attgaacacg agcttccagg cctggttcag
     6481 cttattcgtc atactgacaa agaataatca atgtgctatg gagtaacctc agaaaataac
     6541 acactgagtg tgtgaatatc gttattaaat acatatcagt ggaacaaact tctggctgtt
     6601 ctgaatagtc cagccagaag cgcctgattt atttccctgc acatcgattt tctgttaatg
     6661 cttgtttcaa cttcacgcta acccgtgacc ctcttcgcag acagcgatta tcatagcgct
     6721 atgatttctt tgactatgca acacaggtga attcgccatg gatcctttgc acgccattct
     6781 gcttaccgtc ggcctgtttg tgctgacgtt cttcaaccct ggcgccaacc tgttcgtggt
     6841 ggtgcaaacc agcctcgccg ccgggcggcg cgcaggcgtg ctgaccgggc ttggtgtggc
     6901 gctgggtgat gcgctctatt ccggtcttgg tctgttcggc atggcgacgc tcattaccca
     6961 gtgcgaggga ctcttttcag cgatcaaaat tggcggtggc ctttatctgc tgtggttcgc
     7021 gtttaaaagc atgcgccgac agccatcgcc gatgacaccc gcgctggctc atcccatcgt
     7081 tgcgccatgg tacgtctttt tccgcaccgg aatgattacc tgtctctcca acccgcagac
     7141 ggtactgttt tttatcagta tcttctccgt caccctcagc gccacaacgc ccgcctgggc
     7201 caaactgctg gcgtggctgg ggattgtgct cagctctgta acctggcggc tgttcttaag
     7261 ccaggccttt tccctgcccg ccgtccggcg ttcatacgcc agcatgcagc gcatcgccag
     7321 ccgggtgatc ggcgcggtga tcggcctgtt tgccgtgaag ttaatctggg aaggggtgat
     7381 gcgaaaataa caccagtaaa agggtcgttt attacgcgat tgttaaattt aagtttgata
     7441 gtttcgcgcc gatattactt aggcaaccct gcctaaatga tggacgatcg ctatgctgaa
     7501 aaatactcgc gttataaccg gaattattat cgcgttgggg gtattttgct tactctaggc
     7561 ggcaacagga ggtctgtttt attctgcggt cagtaatgac cggcataatt tccagcgttc
     7621 cgggatcctc aacgctcaac aggaaaatct aagcgacagt gttaacactc tgatcaaaac
     7681 ccgcgtcacc gtcacccgtg tggcgatccg ttttctgaaa aatcagcgcg atccggcctc
     7741 tctggaggcg atcaataaac tgctcaatac cgcgggcgac tcccttaaca aggctgaaaa
     7801 ttattataaa tcctggcagg ggctgccgcc tgttgtcggg cagagtgcaa ctttgacggt
     7861 ggagatggat aaaaccttcc gtcagatgca tgacgtgctg cgccagtcga tagactacct
     7921 gcgcgccgac aattaccagg cctacggcga ccttgatgcc cagcaggcgc aggatgatat
     7981 ggaagccagc tacaaccgct ggcgggcgga aaacaacatg ctgttgaaag gtgccgccga
     8041 ggataaccag cgcagcttcg tcaacatgca ctggacgctg ggggtgatcc tggtttcggt
     8101 cattaccgtg ctgattgtga tctggcttgg cctgcagcat ctgctgctga aaccgcttcg
     8161 cagcattatg aatcacattc gtaccatcgc ccgtggtgat ctgacgcaga ccattgccat
     8221 caacagccgc aacgaaatgg ggcaactggc tgcaagcctc aatgagatgc agcagtcgct
     8281 ggtgactacc gtcagcgccg tgcgtggcag caccgactcc atctacaccg gcgcggggga
     8341 aattgccgca ggcagtcatg atctctcttc ccgcaccgaa caacaggcgt catcgctgga
     8401 agagaccgca gccagtatgg aacagctgac cgcgacggtg aaacagaaca ccgataacgc
     8461 ccggcaagca acactgctgg caaaaaccgc ctcggaaacc gctgcgcgcg gaggccgcgt
     8521 cgtggatacc gtcgtccata cgatgagcga aattgccgac agttcacagc aaatcgctca
     8581 tattaccagc gtcattgata gtatcgcttt tcagaccaat atcctggcgc tgaacgccgc
     8641 cgttgaagcg gcgcgtgcag gggaacaggg acgcggattt gccgtggtgg ccggtgaggt
     8701 gcgtacgctg gccagccgca gcgcacaggc ggcgaaggaa attaaagggc ttatcgataa
     8761 ctctgtcagc cgggtgaata ccggttccag tcaggtaacc gaggccggta acaccatgaa
     8821 agaactggtg gaagcagtga cccgcgtgac agatatcatg agtgaaatcg cctcagcgtc
     8881 tgatgagcag agccggggta ttgaacaggt gagcctggcc gtggcgcaga tggacagcgt
     8941 gacgcagcag aacgccgcgc tggtacagga atccgcagcg gctgcggcgg cactggaaga
     9001 tcaggccgaa cagctgcgcc aggcagtagc ggcgtttcgt ctcaacgggt cgtcaacgtt
     9061 cgacgcgaag ccagccgcgg cggtgaaaac tcctgtactg ctgcgcccgg cgaccgtagc
     9121 gccaggcagc gacagcaact gggaaacgtt ctgatagccc ttccgccctc tccgtgcgga
     9181 gagggcttca cgttttacgc cccaacgctt ccccacacca ttttcccttt gtggaacgtg
     9241 gcggttcgtg gcgaaatgcg tgccacggct tccgccgagc aggaggcgtc caccagcaca
     9301 aaactggcgt cgtcctgcgc tttcggccag acacgttccc ctttgtcgtt cagcggcagc
     9361 acatcacccg tcgcgaaaga gagtgcacgg gacagcgtgc cttcattcgg tcggatatag
     9421 agctgtgcgt agaggttcgc tttttccagc atgtcgccga gaccgtatgg agaccagtgg
     9481 tcaatcacgc tgtcggtgcc ggtcattaca aacacgcctt tatcccgtaa ctgtttcagt
     9541 ggcatgtgca gcgtgccgat cggcaccgtc gaggcgatgg ttacctgctg cgccgccata
     9601 cgggtcgcca gcgcatcgac ctgtttctcg tcgagcgttg ccagcgcaaa agcgtggctg
     9661 atggtgagtt tgcccttcag ttgcggcgtt ttctcaaccg tttccaccat ataattcacc
     9721 gccgccacgc ccgccgggct ggtttcatgc agatgaatat cgatgccttt gtcgtagtcg
     9781 agcgcaatct gaaacatggt gtcgagggat ttttccatcg cgccgtcaac gttcgtggga
     9841 tcaagtccac ccacgtagtg cgcccccgcc tgcatcgctt cacgcatcag cggttcgcat
     9901 tttgacaaca gtaaaccgtg ctgtggaaac gctacgattt cacagtcgaa acccggcttg
     9961 cgctgcgcca gcacggtctg caggttttcg aggtttttca atcctgaaac cggatcgata
    10021 ttgcaatggc tacgcgccac cgtggtgccc ttcgactgca gcagatcgat aagctttccg
    10081 gcgcgctcct gcgtataggg ttgcagttcc ggcagcaatt tttgctcaag gcggatcatg
    10141 tcctgaatgg tggttcccgc cgggcgattc agcgaacgcc acgggccgcc ataaaacgtc
    10201 ttatcgagat gaatatgcat atcgcgcatg gtcggcagca tcagcttgcc gcccgcgtcg
    10261 tagtgtggca gcgtggcatc cgggtggttt ttgttctcgc gcaacgcgac gattttaccg
    10321 ttgttgatct cgacagtctg cagcgcggtc atcgtatgga cgggcacgct gccgtcaaac
    10381 tcaaaaccgg tttccagaag ca
//
