LOCUS       c00108_NZ_QAZU..       12523 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_QAZU01000008.1 Lactobacillus helveticus strain DS3_8
            DS3_8_8_length_46645_cov_34.406724, whole genome shotgun sequence.
ACCESSION   NZ_QAZU01000008
VERSION     NZ_QAZU01000008
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:34:29
            Original ID  :: NZ_QAZU01000008.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12523
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12523
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[436:2523]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      437..2523
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     cand_cluster    1..12523
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="single"
                     /product="LAP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12523
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="LAP"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /tool="antismash"
     CDS             3..185
                     /locus_tag="ctg108_1"
                     /transl_table=11
                     /translation="VFQDIGVLLVVRQRVLMKQAVAVSWHLDFNFAKLRIHLAKVGTVP
                     RIAGIPAVSCIRIIT"
     CDS             complement(437..1084)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg108_2"
                     /sec_met_domain="YcaO (E-value: 9.6e-21, bitscore: 66.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNNWHFSSLGIDKVKKLSGKYTGLLTDEVFYTQGSNTGIHMNIC
                     TASLPNYEKFIVSPKSEINYHLAGYGTNLNDSLTRLGGESVERAAGAVSQLYLKKRIVR
                     ATYSELNEKAINLEYLTPYTNEQLKRLHSLNSDFLSKNPDFETQQDWVRANSLFYPQQS
                     IYIPKNTFLFGSQSKKRTFLAVSTGTAAHINWQKALLNSLIEYIQIDAFMYS"
     PFAM_domain     complement(446..880)
                     /aSDomain="YcaO"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02624.18"
                     /description="YcaO cyclodehydratase, ATP-ad Mg2+-binding"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg108_2_0001"
                     /evalue="1.10E-17"
                     /label="ctg108_2"
                     /locus_tag="ctg108_2"
                     /protein_end="213"
                     /protein_start="68"
                     /score="64.5"
                     /tool="antismash"
                     /translation="GYGTNLNDSLTRLGGESVERAAGAVSQLYLKKRIVRATYSELNEK
                     AINLEYLTPYTNEQLKRLHSLNSDFLSKNPDFETQQDWVRANSLFYPQQSIYIPKNTFL
                     FGSQSKKRTFLAVSTGTAAHINWQKALLNSLIEYIQIDAFM"
     CDS             complement(1074..1970)
                     /locus_tag="ctg108_3"
                     /transl_table=11
                     /translation="MKYVELKDGSVKYRISRDLLYIRLGIWDYTEITLDRQSFVNNNSN
                     FDEFTQLFCQLLDGQRKKLSDFEDPYWGSLIDELIEGNLLIGYEEKAKSKVYVITDFQE
                     SHKIQKYSALCNQSVEVHSMDEPININDQFNYLVILNNLEVNRLKKINQTFFQNNKSWS
                     MGIIDGKFMHLSTFEPHITGCFECFALGNSLRMADYENYISYLKEERNLRKANNSDSLS
                     LFAYQLLLMLTMQNINSLKGQLLSIYIPKLEFNLEPLHKSALCNLDGLKAQEISEELNV
                     DAQNIIQKILEENKNEK"
     CDS             complement(1975..2523)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg108_4"
                     /sec_met_domain="PF00881 (E-value: 5.5e-14, bitscore: 43.9,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LETLFNSRISKRKFTNANWNLQNLSNLFSGIRVSSDGHRGYASGG
                     GLYPVSLYFFTQGIMKLDDFSVYKYQPCTNSVIKIENMPNKNLSSYVHIENLSHSENIK
                     LAIYLVVNRTKNEFKYGKRGLIFSMIESGEMIQNIALSAAQYDYKMCQLGGYDIEKSNI
                     ALGIDGFASFITACAVLGG"
     aSDomain        complement(2011..2412)
                     /aSDomain="TIGR03605"
                     /aSTool="tigrfam"
                     /description="antibiot_sagB: SagB-type dehydrogenase
                     domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg108_4_0001"
                     /evalue="1.30E-26"
                     /identifier="TIGR03605"
                     /label="ctg108_4"
                     /locus_tag="ctg108_4"
                     /protein_end="171"
                     /protein_start="37"
                     /score="91.1"
                     /tool="antismash"
                     /translation="HRGYASGGGLYPVSLYFFTQGIMKLDDFSVYKYQPCTNSVIKIEN
                     MPNKNLSSYVHIENLSHSENIKLAIYLVVNRTKNEFKYGKRGLIFSMIESGEMIQNIAL
                     SAAQYDYKMCQLGGYDIEKSNIALGIDGFA"
     PFAM_domain     complement(2017..2505)
                     /aSDomain="Nitroreductase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00881.26"
                     /description="Nitroreductase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg108_4_0002"
                     /evalue="1.00E-09"
                     /label="ctg108_4"
                     /locus_tag="ctg108_4"
                     /protein_end="169"
                     /protein_start="6"
                     /score="38.8"
                     /tool="antismash"
                     /translation="SRISKRKFTNANWNLQNLSNLFSGIRVSSDGHRGYASGGGLYPVS
                     LYFFTQGIMKLDDFSVYKYQPCTNSVIKIENMPNKNLSSYVHIENLSHSENIKLAIYLV
                     VNRTKNEFKYGKRGLIFSMIESGEMIQNIALSAAQYDYKMCQLGGYDIEKSNIALGIDG
                     "
     CDS             complement(2544..2813)
                     /locus_tag="ctg108_5"
                     /transl_table=11
                     /translation="MKYNDIYNYGNKIKKISFNRIVSLDSGEKEHYYNRFITNTDSLKL
                     DLDNDFNSSKYAKSFGMYGDAINKEFSTSFKLHEELRGAIFYLL"
     CDS             complement(2923..3126)
                     /locus_tag="ctg108_6"
                     /transl_table=11
                     /translation="MGILLNQFLDKIYLEMIIILTFLQEVLIMKIKDKSRKFDEEKNLN
                     RELPAAGCCCCCTSDKPTKTDD"
     CDS             complement(3736..4098)
                     /locus_tag="ctg108_7"
                     /transl_table=11
                     /translation="MLNEAKNPINSRLIPRFNRLLLFLSFFPDSFYYFTLNDQVTNRML
                     KIVTIKLLLNILMADARLDLTYHRHLLLRNRYENYVMPIIKQCKLVQSRPYCYLDFIFD
                     FVSIPPKIVMDVCHVY"
     CDS             4243..6720
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283:2`,3`-cyclic-nucleotide 2`-phosphodiesterase
                     (Score: 315.6; E-value: 1.2e-95)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg108_8"
                     /transl_table=11
                     /translation="MRSRHVNGIITSLAASALMGLFLTSVQVKADTQQVQQPVAQTTQQ
                     NADSTKQSSTTVYTESSKEVPVVSYTDHQSKPNNDHWSNPAKYKDAIPVQILGINDVHG
                     NIDTTGKTWIGYRSYQNAGNAARLAGYLNNTESDFKKKNPNGTTIRVEAGDIVGASPAT
                     SSLLQDEPTMHALKQMHIEIGTLGNHEFDEGLDEFDRVLEGKAPKKGQFNQEEQDYPHE
                     NSGIQIVVSNLVRKSDGKVPFGWKPYIIKELEYNGKKSKIGFIGIDTTDLPKLTFAKNL
                     KDYDVLDEAESIAKYDKILQDQGVHAIIVLAHTGVETYKGKTQGDAVKILQKLCRIDPD
                     NSVDLYIAAHSHQYANGGVGNTKLVQAASFTKAYDDAIGYIDPSTNDFVKGSLITHVYP
                     VMSATDDKEIQPDPAVEQVIKDAEQRTSKITNSVIGKAAAAKDITKDLNSDTENAIGDL
                     VVDAQMAEAKREGIVADIAITNGGGVRSDLKVEKDGSIKWQSAQSVQPFSNQIQVFEVT
                     GKQLYDLLNSQYDSSNESRYYLLSGMHYVYTTQNDKAFPKKVAVLYDGNNHPVNPNKVY
                     RVITSNYLVDSTSQLKGAKKVADIGVDTDIFVNYLKHQTEEGNLITAPILSRKKAVTSE
                     EAKQLIKEAQDELNKMSHSSSEDNEELNNSIDSINTNSNNTSANNQVNVEKDNFTKDET
                     ITLTHNAFVYDKNGKLVLKLGRNLFLKKGSHIRPLNNAAKVLINKHEYYQIGENEFVKV
                     ANTIERKTIVLRLKHNAYLYSKSGKTIKNGKKKVLLKKGKKVRVKATSIVKIGHSKYYQ
                     IGKNQFIKVANFE"
     PFAM_domain     4528..5304
                     /aSDomain="Metallophos"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00149.30"
                     /description="Calcineurin-like phosphoesterase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg108_8_0003"
                     /evalue="5.20E-08"
                     /label="ctg108_8"
                     /locus_tag="ctg108_8"
                     /protein_end="354"
                     /protein_start="95"
                     /score="33.7"
                     /tool="antismash"
                     /translation="ILGINDVHGNIDTTGKTWIGYRSYQNAGNAARLAGYLNNTESDFK
                     KKNPNGTTIRVEAGDIVGASPATSSLLQDEPTMHALKQMHIEIGTLGNHEFDEGLDEFD
                     RVLEGKAPKKGQFNQEEQDYPHENSGIQIVVSNLVRKSDGKVPFGWKPYIIKELEYNGK
                     KSKIGFIGIDTTDLPKLTFAKNLKDYDVLDEAESIAKYDKILQDQGVHAIIVLAHTGVE
                     TYKGKTQGDAVKILQKLCRIDPDNSVDLYIAAHSHQY"
     PFAM_domain     5542..6000
                     /aSDomain="5_nucleotid_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02872.20"
                     /description="5'-nucleotidase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg108_8_0004"
                     /evalue="4.80E-27"
                     /label="ctg108_8"
                     /locus_tag="ctg108_8"
                     /protein_end="586"
                     /protein_start="433"
                     /score="95.1"
                     /tool="antismash"
                     /translation="IGKAAAAKDITKDLNSDTENAIGDLVVDAQMAEAKREGIVADIAI
                     TNGGGVRSDLKVEKDGSIKWQSAQSVQPFSNQIQVFEVTGKQLYDLLNSQYDSSNESRY
                     YLLSGMHYVYTTQNDKAFPKKVAVLYDGNNHPVNPNKVYRVITSNYLVD"
     PFAM_domain     6328..6504
                     /aSDomain="SlpA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03217.16"
                     /description="Surface layer protein A domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg108_8_0005"
                     /evalue="1.10E-13"
                     /label="ctg108_8"
                     /locus_tag="ctg108_8"
                     /protein_end="754"
                     /protein_start="695"
                     /score="51.5"
                     /tool="antismash"
                     /translation="TLTHNAFVYDKNGKLVLKLGRNLFLKKGSHIRPLNNAAKVLINKH
                     EYYQIGENEFVKVA"
     PFAM_domain     6535..6708
                     /aSDomain="SlpA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03217.16"
                     /description="Surface layer protein A domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg108_8_0006"
                     /evalue="5.80E-14"
                     /label="ctg108_8"
                     /locus_tag="ctg108_8"
                     /protein_end="822"
                     /protein_start="764"
                     /score="52.4"
                     /tool="antismash"
                     /translation="RLKHNAYLYSKSGKTIKNGKKKVLLKKGKKVRVKATSIVKIGHSK
                     YYQIGKNQFIKVA"
     CDS             complement(6874..8133)
                     /locus_tag="ctg108_9"
                     /transl_table=11
                     /translation="MKSITQFNQEKDTKSLISSFTKLIGLGDLSKKVNFKRHSLVSLLM
                     VITWMIKARFARKSLYRCQRAKNFTAKTGRNVLNDGRINWQKLVCLAAVKLISVLKPVI
                     DRRRRLALIVDDTLMARSCSKKTELLAKVYDHDKHEFLTGYRGLTVGWSDGNTFLPVNF
                     ALMSNKKKENMIGNQPVTADQCSIAGRRRTQAQRPMNAVTVELLKQAVALGLPAEYVLF
                     DSWFSLPKIFWQLKQLGLDSVGMLKQTKKVYYRYRATAFMMSKACMNVWLPPKRGSKGK
                     YLVLATMQYKLHPQEIIQLYGRRWQIETYFKAAKQYLALNKSQIQSYDGQCGYIAVTAL
                     TYDLLAWQERQSIDDRTLGDLLYLMNEALPDLAFEEALVYLLTALKEVKAEISATVEQI
                     LDNFIKLLPVFMQKQLLRTA"
     PFAM_domain     complement(7366..7917)
                     /aSDomain="DDE_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13546.8"
                     /description="DDE superfamily endonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg108_9_0007"
                     /evalue="2.10E-20"
                     /label="ctg108_9"
                     /locus_tag="ctg108_9"
                     /protein_end="256"
                     /protein_start="72"
                     /score="73.3"
                     /tool="antismash"
                     /translation="TGRNVLNDGRINWQKLVCLAAVKLISVLKPVIDRRRRLALIVDDT
                     LMARSCSKKTELLAKVYDHDKHEFLTGYRGLTVGWSDGNTFLPVNFALMSNKKKENMIG
                     NQPVTADQCSIAGRRRTQAQRPMNAVTVELLKQAVALGLPAEYVLFDSWFSLPKIFWQL
                     KQLGLDSVGMLKQTKKVYYRY"
     CDS             complement(8332..9924)
                     /locus_tag="ctg108_10"
                     /transl_table=11
                     /translation="LILCLANIHITLGILAVCGIVWLIVRLFKKHDKINSSNAGNVDQS
                     VDSTDTPKSTAKPVVHEGNLVAGNKSYNINPKILPLLYFTDGQLKNIDSEVGEPSAISI
                     NFPVAEGQFQKLSYYPSYSGLTSEQRNGFLTWLTTDLSNVPDIGFAFLLLYCLERHILH
                     DEYLEESLKIISKLQGQISNGSFDYYSSTSIGYIFFIHKRLDLLKYVDLNKCDIKLQIL
                     LSHKLSADQLISLATEVDFRNRYYIKEYPELFKKALIESLKREFGSEYFQYELSNIQKL
                     KKEPYMFSNYSLRKGNNRPDLLMPDPLSDRKLCHDIYAELQKAHDQVKGFLEIKRAVEP
                     KKDKSKKKIAKPKRINSKTGYPMSTDKQIKNATEQLKLTRKFLKNNQTNPYKSRNSQEK
                     IEDWCWNNSAEKMDNADLEYKKGEWDKAEKLWLACVAINYRAANRLRIMYQKEHRFNDA
                     VQIIDFAIDSPVLRKVNNDSYVTDFKKKLETAEQKSMKHENKDQSKLSEEDFKKLNSDS
                     DYWFKKVNNITYS"
     PFAM_domain     complement(9421..9585)
                     /aSDomain="TerB_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13208.8"
                     /description="TerB N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg108_10_0008"
                     /evalue="1.50E-09"
                     /label="ctg108_10"
                     /locus_tag="ctg108_10"
                     /protein_end="168"
                     /protein_start="113"
                     /score="38.0"
                     /tool="antismash"
                     /translation="QKLSYYPSYSGLTSEQRNGFLTWLTTDLSNVPDIGFAFLLLYCLE
                     RHILHDEYLE"
     CDS             10058..10240
                     /locus_tag="ctg108_11"
                     /transl_table=11
                     /translation="MLRFGFLMNPVPFLPYPGMIARLTALLALPVVRALNDAFSDGLRN
                     TLLLLITNFPQNKTD"
ORIGIN
        1 atgttttcca agacatcgga gtgctgcttg tagtcaggca gcgtgtgctg atgaaacagg
       61 ccgttgcggt ctcgtggcac ctggatttca attttgccaa actgcgtatc caccttgcga
      121 aagtaggtac cgttcctaga attgccggta ttccagccgt ctcttgcata aggattataa
      181 cctaaaaagg cggttaattc agcttctaac aagtcattaa ctgcttgttg taattcttta
      241 cgcaataaat cattaatttt gtcttgattg aatagagctt gagcaatatt tttggtaaaa
      301 tcattcatga aggagttctt ctttctgtat gtgttttttg ttcaaaccaa tcatacgaga
      361 aaggaactcc tttttctaat gttttaagaa attaatttaa ggaatcattc atccttacac
      421 aaactatttt acagtctcag gaatacataa aagcatctat ttgaatatac tctatcaaac
      481 tattcaataa agctttttgc caattaatgt gtgctgcagt tccagtagaa acggctaaaa
      541 aagttctttt tttactttga gacccaaaaa gaaaagtatt tttaggtata taaatacttt
      601 gttgaggata aaataatgaa ttagccctta cccaatcttg ttgtgtctca aaatctgggt
      661 ttttagataa aaaatcagag tttaaactat gtaatctttt aagttgctca ttagtgtagg
      721 gagttaaata ttctaaatta atagctttct catttaactc tgaataagtt gccctaacta
      781 ttcttttctt taaatataac tgtgaaactg ctcctgcagc tcgttcaaca ctttctcctc
      841 ctaatctagt aagactatca tttagattag taccatatcc agctaaatga taatttattt
      901 ctgattttgg gctaacaatg aatttttcat aattaggtaa tgaagcagta caaatattca
      961 tatgaatacc tgtatttgat ccttgagtat aaaatacctc atctgttaat aggccagtat
     1021 atttcccact taactttttt accttatcaa ttcctaaaga ggagaagtgc cagttatttt
     1081 tcatttttat tttcctctaa tatcttttga ataatatttt gtgcatcaac gtttaactct
     1141 tccgatattt cttgagcttt taaaccatct aaattacaca aagcgctttt atgtagaggt
     1201 tctaaattaa attcaagttt tggtatatat atacttaata attgtccttt taatgaattt
     1261 atattttgca tagtaagcat taaaagaagt tgataggcaa ataaagataa actatctgaa
     1321 ttattagctt tacgtaaatt acgttcctct tttaggtaac ttatataatt ttcataatct
     1381 gccattctta agctatttcc cagtgcaaaa cattcaaaac atcctgtaat atgtggctca
     1441 aaagtagata aatgcataaa ttttccgtca ataataccca tactccaact tttattattt
     1501 tggaaaaatg tttgatttat cttctttaaa cggttgacct ctaaattatt taatataact
     1561 agataattaa actgatcatt tatatttatt ggctcatcca tagaatgaac ttctacactt
     1621 tgattacata atgcactgta tttttgtatt ttatgacttt cttgaaaatc agttattaca
     1681 taaactttag actttgcttt ttcttcgtat ccaataagta agttaccttc aataagttca
     1741 tcaattaaag agccccaata tggatcttca aaatcgctaa gtttttttct ctgcccatct
     1801 aagagttgac aaaataactg tgtaaattca tcaaaatttg aattattgtt aacaaatgat
     1861 tgtctatcaa gagttatttc cgtataatcc catataccta atcgaatata caataagtct
     1921 ctacttatac gatatttaac actaccatct tttaattcta catacttcat tctattaacc
     1981 tccaagaaca gcacaagcag ttataaagct agcaaaacca tcaattccta atgctatatt
     2041 acttttctct atatcgtatc cacccaattg acacatttta taatcatatt gagctgcact
     2101 taatgcaata ttctgtatca tttctcctga ctctatcatt gaaaaaatta gaccacgttt
     2161 accatattta aattcatttt tggttctatt aactactaga taaatagcta acttaatatt
     2221 ttcagaatga ctcaaatttt ctatatgtac gtaagatgat aaattcttat ttggcatatt
     2281 ttctattttg attacgctgt tcgtgcatgg ctgatattta tataccgaaa aatcatcaag
     2341 tttcataata ccctgagtga aaaaatataa acttacggga taaagtcctc cgccagatgc
     2401 atatccacga tgaccatctg atgataccct aattccagaa aacaaattgc tcaaattttg
     2461 taaattccaa ttagcatttg taaattttct tttactaatt ctgctattaa aaagagtttc
     2521 caaattatag gaatttttct tttctacagg aggtaaaaaa ttgctcctct taattcttca
     2581 tgtaatttaa aagaagttga aaactcttta ttgatagcat caccatacat tccaaaactt
     2641 ttagcatatt tgctagaatt aaaatcgtta tctaagtcta actttagaga atcggtattt
     2701 gtaatgaaac gattataata atgttccttt tcaccggaat ctaaagatac aattctatta
     2761 aaacttattt ttttaatctt attaccataa ttatatatat cattatattt catgctaatc
     2821 ctctttataa aaaagggccc taataattac ctatcagact tatagaaaat aaaaatatat
     2881 tgtctacaag tcttagatat tataaggcct ctttttttgt aattaatcgt ctgtttttgt
     2941 aggtttgtca cttgtacaac agcaacaaca accggcagca ggcaattctc tgttcaagtt
     3001 cttttcttca tcaaatttac gacttttatc tttgatcttc ataattaaaa cctcctgtaa
     3061 aaaagttaaa ataataatca tttctaaata aatcttatct agaaattggt ttaataatat
     3121 tcccatattt ttaatctgtc aatatatctt taaattattt tttataaaat aatcattcaa
     3181 tagaactaaa atgtcttcca tacaaaaaag gcgcctaaat catgaccaaa ttgcttaggt
     3241 gattttttgt cttcaatttt acggagtgtc attattttat tatctttaca ctaaatagta
     3301 ttaatactat attcttctag gaacttagaa ctactttata tctttaatcc atactttatt
     3361 gctcgagcat taccaaattt ttcttcttct cgaagcttct taagtgcacg acagattgta
     3421 acttcactat attgtggaat atgctcattt agctccttaa ttgacaatgg ctctgtatta
     3481 cttttaagct taatttatca acaagcaaat ctgtttgata atggggctca accgttcatt
     3541 ggaatctcga taatctttta aaaccacacc taaaaaataa tcctaaaacg gtaaataagt
     3601 cgttctcctt attcatccaa ttaaaagaac tctcctgtaa tgctcaataa taatcagctt
     3661 tagtatcttc aatagatttt tcaatactga tatattttcc tacatcaaag tcagccttat
     3721 acattgtcaa taaaattaat agacgtgaca tacgtccatt actatcttgg gagggatcga
     3781 cacaaaatca aaaataaaat ccagatagca gtaagggcga gattgtacca acttacattg
     3841 cttgattata ggcatcacat aattctcgta cctattgcgg agtaataaat gccggtggta
     3901 ggttaaatct aacctcgcat ctgccatcaa aatattcagt aataatttga ttgtcactat
     3961 ctttagcatt cgattagtaa cttgatcatt tagggtaaaa taataaaaag agtctgggaa
     4021 aaaactcaga aataacaaaa gcctattaaa tcttggtatt aaccttgaat taataggatt
     4081 ttttgcttca ttaagcatca ctatttccta ggtacataca gttttcttga tttctagctt
     4141 tcaagttcca gttattaact ataattgata attgaaatta aattgttcac attttatact
     4201 ttacttaata aatattgttt aatttaattt gaggagtata aaatgagatc acgtcatgta
     4261 aatggaatca ttacgagttt agctgcaagt gccttaatgg ggctattttt aacaagtgtc
     4321 caagttaaag cagatacaca acaagttcag caaccagttg ctcaaactac tcagcaaaat
     4381 gctgattcaa caaagcaatc ttcaactact gtttatactg aaagctcgaa agaagtacca
     4441 gtagtcagtt acactgatca ccagtcaaag ccgaacaatg atcattggtc aaatcccgct
     4501 aaatataaag atgccattcc tgtacaaatt ttaggtatca atgatgtaca cggaaatatt
     4561 gataccactg gtaaaacttg gattggctat cgttcctacc aaaacgcagg taatgctgcc
     4621 agattggctg gatatttgaa caataccgaa tctgatttta aaaagaaaaa tccaaatgga
     4681 acaactatca gagttgaagc tggtgacatt gtgggagcat ctccagcaac ttcttcatta
     4741 ttgcaagatg aacctacaat gcatgcacta aagcagatgc acattgaaat tggtacttta
     4801 ggtaatcatg aatttgatga aggactagat gaattcgata gagttttaga aggaaaagcc
     4861 cctaagaaag gacagtttaa ccaagaagaa caggattatc ctcatgaaaa ttctggcatt
     4921 caaattgtag tttctaattt ggtaagaaag tccgatggaa aggttccttt tggctggaag
     4981 ccatatataa tcaaagaatt agaatacaat ggtaaaaaat caaaaattgg ttttatcgga
     5041 attgatacaa cagatttacc taaattaact tttgccaaaa atctaaagga ttatgatgtg
     5101 ctagatgaag ctgaatcaat tgctaaatat gacaagattc tgcaagatca aggtgttcat
     5161 gcaatcattg ttttagcaca taccggtgta gaaacttata aaggaaagac tcaaggcgat
     5221 gcggttaaaa ttttacaaaa actatgtcgt atcgatcctg ataattcagt cgatttatat
     5281 attgcagctc actcacatca atatgcaaat ggtggagttg gcaatacaaa acttgtccaa
     5341 gctgcaagtt ttacaaaagc atatgatgat gctatcggtt atatcgatcc atcaactaat
     5401 gattttgtaa aaggaagttt aatcactcat gtttaccctg ttatgtcagc aactgatgat
     5461 aaagaaattc agcctgatcc agctgtagaa caagtcataa aagatgccga gcaaagaact
     5521 tctaagatca ctaatagtgt gattggtaaa gcagcagccg caaaagatat taccaaagat
     5581 cttaattcag ataccgaaaa tgcaattggc gatctagtag ttgatgcgca aatggcagaa
     5641 gctaagcgag aaggtattgt tgctgatatt gctataacta atggtggtgg tgtaagaagt
     5701 gacttaaaag tcgaaaagga tggctcaatt aagtggcaat cagcacaatc agtccagcct
     5761 tttagtaatc aaattcaagt tttcgaagta actggaaagc aactttatga tctacttaac
     5821 tcacaatatg attctagcaa tgaaagcaga tattatcttt tgagtggaat gcattatgtt
     5881 tacactacac aaaacgataa agcttttcca aagaaggttg cagttcttta tgacggcaat
     5941 aatcaccctg ttaatccaaa taaagtttat cgcgtgatta caagcaatta tttagttgat
     6001 tcaactagtc aattgaaagg tgcaaaaaag gttgcagata ttggggttga tactgatatt
     6061 ttcgttaatt accttaaaca tcaaacagaa gaaggcaact taatcactgc ccctattctt
     6121 agccgtaaga aagcagttac ttcagaagaa gctaagcaac taattaagga agcacaggat
     6181 gaattaaaca aaatgagcca tagctcctct gaagataacg aagagttaaa caatagtatt
     6241 gattcaatta atacaaattc aaataatact tcagccaata accaagtcaa tgttgaaaaa
     6301 gataacttta caaaagatga aacaatcaca ttaactcaca atgcgtttgt atatgataaa
     6361 aatggtaagc ttgtattgaa gctaggaaga aatctattct taaagaaagg ctcccatatt
     6421 cgtcctttaa ataatgcagc aaaagtactt attaacaaac acgaatacta tcaaattggc
     6481 gaaaacgaat ttgtcaaagt agcaaatact attgaaagaa aaacaatagt tttgcgttta
     6541 aagcacaatg catatctata ttcaaaatct ggaaaaacaa ttaaaaatgg taagaagaag
     6601 gttctattga agaagggcaa aaaagtaaga gtgaaagcta cttctattgt aaaaatcggt
     6661 catagtaaat actaccaaat tgggaaaaat caatttatca aagtggcaaa cttcgaataa
     6721 ataagtgaaa actaaaagct agtaataaca ctttaaaaat gtgttgtttc tagcttttta
     6781 atattcgatt ctaatttatt ttactgaaac ttgaaagcac taaaactagc cggatccata
     6841 ttggatctgg ctttttgtct cttaaattag tttttaagct gtccgcagca gctgcttttg
     6901 catgaaaacc ggcaataact taataaagtt gtctaatatt tgttccactg tggcggagat
     6961 ctctgctttt acttctttaa gagcggtaag caggtagacc aatgcctctt caaaggctaa
     7021 atcaggcagc gcttcattca ttaaatagag taaatcgcct aaggttcgat catcgatact
     7081 ctgtctttct tgccaagcca acagatcata agttagagct gtcacggcaa tgtagccgca
     7141 ttgcccgtca tagctttgaa tctgtgattt gtttaaggct aagtattgct tagctgcttt
     7201 aaaataagtt tcgatctgcc atctgcggcc atagagctga atgatttcct gtggatgcag
     7261 cttgtattgc atagttgcca gtactaaata ttttccttta ctgccgcgtt ttggcggcag
     7321 ccaaacgttc atacaggcct ttgacatcat aaaggcggtc gcgcggtaac gataataaac
     7381 tttcttggtc tgcttaagca tgcctacgct gtctaaccct aattgtttca gctgccagaa
     7441 tattttaggt aaagagaacc agctgtcgaa taagacgtat tcagccggta agcccagcgc
     7501 gacagcctgc ttaagcagct ccaccgtgac agcgttcatt ggtctttgag cctgggttct
     7561 tctacgaccg gcaattgagc actgatcagc agtaacaggc tgattgccaa tcatattctc
     7621 ttttttctta tttgacatca aagcaaaatt aaccggcaag aaggtattgc catcgctcca
     7681 gccaacagtt agaccacgat agccggttaa aaattcatgc ttgtcatgat catagacttt
     7741 agccaataat tcggtcttct tagaacaaga acgagccatt agcgtgtcat caacgattaa
     7801 agccaatctt ctacgtcgat caattaccgg tttcaaaaca gaaatcagtt taacagcagc
     7861 caaacagacc agcttctgcc agttgatgcg gccatcattg agcacatttc tgccagtttt
     7921 agcagtaaaa ttcttggcgc gctgacagcg ataaagcgac tttcgcgcaa atctagcctt
     7981 gatcatccag gtaataacca ttaacaggct aaccagggaa tgtcgtttga agtttacctt
     8041 tttactcaaa tcacctagac caattaactt agtaaatgaa gaaattaaag atttagtgtc
     8101 cttttcttgg ttaaattgcg ttatactttt cattgcgtag gatctccttt actttggatt
     8161 tgacacttaa agtataacgc ggagaaatcc tgcgttttta tttttacgca aaaaagacta
     8221 gaaaccatgc ggaaagagcg tgatttctag ctttcaagtt tcagttaaag aatttgagat
     8281 aaaagaaaaa tgatatcttt gcatgttgca ttgatatcat tttttagtaa tttaagaata
     8341 agtaatatta ttcactttct taaaccaata atccgaatca ctatttaatt ttttaaaatc
     8401 ttcctcagat aattttgatt gatctttatt ctcatgtttc atggattttt gttcagccgt
     8461 ttctagcttc tttttaaaat ccgtaacata agagtcattg ttaactttac gtaatacagg
     8521 cgaatctatt gcaaaatcaa taatctgaac agcatcgtta aatctatgtt ctttttgata
     8581 cattattctt aatctgtttg ctgctcgata attaatagcc acacatgcta accataattt
     8641 ttctgcctta tcccactcac cttttttata ttcaagatca gcattatcca tcttttcagc
     8701 agaattattc caacaccaat cttctatctt ttcttgtgaa tttcttgatt tataaggatt
     8761 agtctgatta ttctttaaaa attttcttgt caatttaagc tgctctgtag cattttttat
     8821 ttgcttatct gttgacattg gataacccgt cttagaattt attcgcttgg gcttagcaat
     8881 tttcttcttg cttttatcct tctttggctc tactgccctc tttatttcaa gaaatccttt
     8941 aacttgatca tgagctttct gcagttcagc atatatatca tggcaaagtt ttctatcaga
     9001 caacggatct ggcattaata gatctggtcg attattacct tttcgtaatg aataatttga
     9061 aaacatataa ggttctttct ttaacttttg aatatttgaa agttcatatt gaaaatattc
     9121 tgaaccaaac tctctcttca agctttcaat caaagctttt ttgaataatt ctggatactc
     9181 ttttatataa tatcgatttc taaaatcaac ctctgtagcc aatgatatta attggtcagc
     9241 agataattta tgactcaata aaatttgaag ttttatatca catttattca aatcaacata
     9301 tttgagtaaa tctaatcgct tatgaataaa gaatatgtat ccaatggacg ttgaagaata
     9361 ataatcaaat gagccattac taatctgacc ttgtagtttt gaaataattt taagagactc
     9421 ttctaaatat tcatcatgta atatatgacg ttctaagcaa tacaacagca gaaaagcaaa
     9481 gccaatatcg ggaacatttg ataaatctgt cgtcagccat gttaagaatc catttctctg
     9541 ttcggacgtt aatcctgaat aactaggata ataactcaac ttttgaaatt gaccttctgc
     9601 aactgggaaa tttatcgaaa tagctgatgg ttctcctact tctgaatcaa tattctttag
     9661 ttgaccatca gtgaaataca ataatggcag aattttggga tttatattat aacttttatt
     9721 tcctgctact aaatttcctt catgtacaac aggtttagca gtactttttg gtgtatcagt
     9781 tgaatcaaca gattgatcta catttcctgc attagaagaa ttgattttat catgtttttt
     9841 aaataatctg actattaacc aaactattcc gcaaacagca agaattccta aggttatatg
     9901 aatgttggct aaacataata tcaatattac tatccaaaaa atccaccaaa gacaggaact
     9961 agatgattgt tgatttccct gaccttgtgt agttcttttc ttgttcttaa ttggttttaa
    10021 agtatcaata cttgttcgat gataaaccgc attatacatg ctacgttttg gatttttaat
    10081 gaatcctgtg ccttttttac catatcctgg tatgatcgct cgtttaactg ctctcttagc
    10141 cctacctgta gttcgtgctt taaacgatgc cttcagtgat ggcttgcgaa atacacttct
    10201 tcttctcatt actaatttcc ctcaaaataa aacagattag atattaagct aatctgttca
    10261 ctaatccatt aattaatcaa atccatacta tattcaaatc gttttggctc ttctgtacta
    10321 ccttcacgat ctattactaa atagtatttc ttatcaagat catactgcat gtcttgcatt
    10381 gtaatcgtaa tagcaattgt acgatcagct gcagaaccag ttcgatttgc ttcgataatt
    10441 acattgttag aaatcaaatt gccatcttca tcggtgaagt aagcatgata ttctgctggt
    10501 aagacagtat cactaatcgg cgcagtttgg ttaaacaaca gattcatctt caaattatta
    10561 attctaaatg ttgttgccgc caatttaatt tctgccggtt gagcgataga tcttctagaa
    10621 gttgctttaa tatctaaaac aggaattaac atttcctgaa tagaagaacc accgtgaaca
    10681 taattcttgc ttccacttct agccacgaat tcattcggac ttactggata atagacattg
    10741 gtaggatcat cattatttaa actgacaccc attgttgtat ttttaacacc cattacatta
    10801 atttgacttg gagtgattaa atatcttaaa tgagcatttc cttcataatt ttgcccttga
    10861 agatcgattt tatctttatc ttcaattggc ttttcttgat aaataaatcc atgatcagca
    10921 gtaatgatga tatgagctat accattagtt cttaggactt gaacagcttg cttaatttca
    10981 tcaattgcct tttcagtagc ttcaactaat tctttagttg tctttaattc atgtcctttg
    11041 gcatcgattt gattatgata gaggtaaatt acatttttcc ccgtaatcat ttgcttaatc
    11101 tctttagaag acatttccag gacattcttt aattgaaaag caagattgtt ttcatcatat
    11161 gacttaagta acttgtcccg actgtcagta ttctctgcat tttcaccatt tactttaacc
    11221 ttagaagttt tattatccca ttctaaagtt tcatgaggta gcatcacatt catccccata
    11281 taagtgacgg atggtaaaac cgtaattgca tgattcatct tcattgtcag acgatcatcg
    11341 ctatttagct cttcttctaa ttctttagct acttcataac gcaaggcatc agagaaaatt
    11401 acaactactc tctctcgtac atccctgaca taattatgat aaaagcgttc ttgcttcagc
    11461 ttgacaggaa cctcctttag atcaaaagtt tcattccact gcttaacaga gctatcaagc
    11521 aacatattgc cataataacg atcaatagtt tttttaatat caatataatt atcagtatca
    11581 atgatattag tgtaagctag caaactctta cgataaatcg tgtcaatttt gtagctatta
    11641 tctaagtaat cattcaattc atcttgccaa tcatcaacca ttggcacttt taaattcaat
    11701 aattctgcag catatcgtaa gaatttatat tcgggttcag ttccgccatt gaaattatta
    11761 cgtgtatgat caagcatctg atcgatgatc tcaagcagtt gctcataatc agtaattctc
    11821 ttgccgtcaa atttagcgac taacttagcc aaaattaaat ggttaatttc ttcgaatatg
    11881 ctaatcttag tcaaaatcat ggctggttca tgcttcaaca cggtattcaa attcaaatcg
    11941 cgccaaactg tagatgagca gttgtcatag tattgctgat acttatttga atcagcaata
    12001 cgatcaataa agatttgaac attatcttgt tgtttaaaat aataattttt aaatctatca
    12061 gggagcttat tgtttaattc attggctaaa tatgtgataa aaatgcgctc aactagatac
    12121 ttcagatcaa cttcactatc agcctcacca ccgaagtaat tcatgaccag cttccaaaaa
    12181 gtatcaagta catcatattt actgaacgta aaaatataat gattattagt ataacctgca
    12241 gcaattactt tcatcaacaa ctcattcata tcgagctttt ctgttttagt aattgcagca
    12301 ataataccct tttctggtgt cttatcaaaa gtatcagacc aatacttaac aaaatctgct
    12361 cttctagttt tagcaccaaa gtaactatta tacttcttaa caaaaagcag ttgattctct
    12421 ggaagttgga gttcttccaa gataatttgt gtagcatctg cagtgaagag cttagaataa
    12481 tgttccatat cagttaggta attctcttga attgcaggtc tct
//
