LOCUS       NZ_AP012544.1          10285 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AP012544.1 Lacticaseibacillus casei DSM 20011 = JCM 1134 = ATCC
            393 chromosome, complete genome.
ACCESSION   NZ_AP012544
VERSION     NZ_AP012544.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:24:38
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2628922
            Orig. end    :: 2639207
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10285
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2633922:2634207](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5285)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10285
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10285
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1906..2223)
                     /locus_tag="ctg1_2553"
                     /transl_table=11
                     /translation="MTRGKKILVGVSVLVIVSVVALLSIHNELTDRVNPFISEETSYAK
                     VPLRTRTYRNIEIYSKNGQKLSYTLKFVQGYDTTRKFASIQHKGQYVKRISYVSKPPFL
                     E"
     aSDomain        complement(1924..2211)
                     /aSDomain="TIGR01655"
                     /aSTool="tigrfam"
                     /description="yxeA_fam: conserved hypothetical protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2553_0002"
                     /evalue="8.50E-12"
                     /identifier="TIGR01655"
                     /label="ctg1_2553"
                     /locus_tag="ctg1_2553"
                     /protein_end="100"
                     /protein_start="4"
                     /score="43.7"
                     /tool="antismash"
                     /translation="KKILVGVSVLVIVSVVALLSIHNELTDRVNPFISEETSYAKVPLR
                     TRTYRNIEIYSKNGQKLSYTLKFVQGYDTTRKFASIQHKGQYVKRISYVSK"
     CDS             complement(2220..2882)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 176.7; E-value:
                     1e-53)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2554"
                     /transl_table=11
                     /translation="MINARKISKSFGEKMILNKVSYQFENGKSYAIIGKSGSGKTTLLN
                     ILGGLEEPSSGLVELNGLAVSKANVQKMWRDHLGFIFQNFGLIENGTVEANLKIGFANR
                     RLNKSGSRSAMKQALAQVELENLPLNQRVFTLSGGEQQRIALARALLKKPDVILADEPT
                     GSLDPENTDIVLRVLFNSFGPEATIIIATHSQEVWQKCDYVIQILDGDLQNKEVNKQ"
     PFAM_domain     complement(2394..2834)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2554_0015"
                     /evalue="2.60E-32"
                     /label="ctg1_2554"
                     /locus_tag="ctg1_2554"
                     /protein_end="163"
                     /protein_start="16"
                     /score="112.3"
                     /tool="antismash"
                     /translation="LNKVSYQFENGKSYAIIGKSGSGKTTLLNILGGLEEPSSGLVELN
                     GLAVSKANVQKMWRDHLGFIFQNFGLIENGTVEANLKIGFANRRLNKSGSRSAMKQALA
                     QVELENLPLNQRVFTLSGGEQQRIALARALLKKPDVILADEPT"
     CDS             complement(2894..4879)
                     /locus_tag="ctg1_2555"
                     /transl_table=11
                     /translation="MLRVIKSLLFAMTTVVVALLFLETIKAYDNNTIPNTTSAISVESW
                     DGKRSKNSVFELLKKKATEKDLVLIKARLNTINEHQNKIVYDFNPKNKRQYSIKKGMNV
                     GLLNQRSLQLEDVNGMYYTDAKGKQLKTLATAFSDAGLPAHIYSPSLINASVADMVSAN
                     FLLVAIGIISMMFIIMLLEKIYRFKSYAIMEVNGMTKSRIIKHDWWAGLPVFVSSEAAA
                     VIIIFAVGASSLTFLGLKLFALYILILLLILVSGFFVLDVLSYATLWLIDIYTSIKGSR
                     QSRSFMIFGYMIKISLVILVSINGVSLYNNFLRYSQDSKTMNHWITRHSGYTVQFGQIN
                     ETNDNQMNFISRKSHQMIDDDSNVIISRNFQEFHPNVRDDEPMSGNVMFVNGTYLKYNP
                     ILAYDGTQISYSAPQQGRLMVLIPSNRVDQTNNFLKKLNKLIVFQRRLPNSFDVPRVTE
                     FTVVKTKNNQSLFNYTVGKAIEDSVSRNAIVVIIDKKVFSDNFYWATMTQGMVQFSELK
                     PLKSDIKKLGLESNITGITNAKTRLSDFNTFMVRQIFILVAITSLSLLQLLFAVSFMSV
                     TFLKDQRQRMAIRKVFGLSNQSILMRFMVLNGLLDALLIVGVLTVKSAINILPYGFFYL
                     MFEILIILFTASRAESGLVDTLNHGN"
     CDS             complement(5001..5285)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2556"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.2e-17,
                     bitscore: 61.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIKSVIVSALAAATIGVSAVPVLAYTVDVQGGTWNYGVGSTYVW
                     SYYSHNSRTHSAAVKGAYSASSGWISPGTEARASAQKSYFGNQSFYNVK"
     aSDomain        complement(5010..5285)
                     /aSDomain="TIGR01653"
                     /aSTool="tigrfam"
                     /description="lactococcin_972: bacteriocin, lactococcin 972
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2556_0003"
                     /evalue="1.10E-12"
                     /identifier="TIGR01653"
                     /label="ctg1_2556"
                     /locus_tag="ctg1_2556"
                     /protein_end="92"
                     /protein_start="0"
                     /score="46.1"
                     /tool="antismash"
                     /translation="MRIKSVIVSALAAATIGVSAVPVLAYTVDVQGGTWNYGVGSTYVW
                     SYYSHNSRTHSAAVKGAYSASSGWISPGTEARASAQKSYFGNQSFYN"
     PFAM_domain     complement(5013..5192)
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2556_0016"
                     /evalue="1.00E-12"
                     /label="ctg1_2556"
                     /locus_tag="ctg1_2556"
                     /protein_end="91"
                     /protein_start="31"
                     /score="48.5"
                     /tool="antismash"
                     /translation="GGTWNYGVGSTYVWSYYSHNSRTHSAAVKGAYSASSGWISPGTEA
                     RASAQKSYFGNQSFY"
     CDS             5635..6501
                     /locus_tag="ctg1_2557"
                     /transl_table=11
                     /translation="VTYTFSNFGFLLAAMRKRRRLRMTDIADNTSLSTISRFERGNQNI
                     SLSLARELFERVHASLPETAALVDNSTPVSDMWRRLNEAALTEDVLMLEKEITAFETMH
                     DTVSSMIVIVLKTYRSMFNHEDLDWGHSISPVIRYLLGNGRWFLFEFQLFAASIYLASP
                     KDSKRCLIRAIHEIGYTNSNIFQEPFTTGLFYAAVSAIEKSDLSSANVLLGNLRGLAPT
                     TDTIFLKYRIRMVEAALRYSLRDDPREYRNIVDMLTFLHTIGADNYCEADQRWLKRMGI
                     EIDLNLD"
     CDS             complement(6607..7050)
                     /gene_functions="regulatory (smcogs)
                     SMCOG1284:transcriptional regulator, MarR family (Score:
                     60.2; E-value: 3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2558"
                     /transl_table=11
                     /translation="MTDSIGILVKKLNNDLQRYADREAKQMGLTQVQMSIIDFLARNDS
                     HRSLYQTDVEREFNIQKSSATALLQLMERKALIVRTPSKEDARYKAIQLTPKAQHDAAH
                     IRAYFQQNDAFLREALGENADVVMTALEQLKNVMARKLAEVNG"
     PFAM_domain     complement(6787..6969)
                     /aSDomain="MarR_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12802.9"
                     /description="MarR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2558_0017"
                     /evalue="3.40E-11"
                     /label="ctg1_2558"
                     /locus_tag="ctg1_2558"
                     /protein_end="88"
                     /protein_start="27"
                     /score="43.1"
                     /tool="antismash"
                     /translation="GLTQVQMSIIDFLARNDSHRSLYQTDVEREFNIQKSSATALLQLM
                     ERKALIVRTPSKEDAR"
     CDS             7180..8574
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 224; E-value:
                     4.1e-68)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2559"
                     /transl_table=11
                     /translation="MTRKVSAKLYLSILATGLMAFCGVLIETAMNVTFPTLMKQFQVNT
                     GTIQWLTTGYLLVVSIIVPISGFLKRRFTTMQLFLTATAFFILGLAICSVANDFALLLI
                     GRLIQGCGTGIALPLMFNIILEQAPLDKIGFLMGIGTLVTAIAPALGPTYGGVLVDLNW
                     HLIFIFLLVVMVIALFLGLFSITQVTKPVHVHLDVIAWLLIAIFFAGAILGLNRIENAP
                     GQAAIYGVVAILGLVGYAWRSLHVKEPLINLRLLKNWSFDWHVVTFLIIQIINVGFAFV
                     LPNYLQLVNHTSSFTAGLLLLPGAALGACMAPMSGNLYDNLGPGKPIFIGLALQLVGIL
                     LLLATALTATPVILMLGYAAVMLGTGFAMGNIMTSGQAQLTQTETTDGNAIFNTMQQFA
                     GALGTACVSLIVALAQVPKTTAHTTAVGALHAFWFLLILAIIGDLAIAIGLKTRHAQNQ
                     AASHDA"
     PFAM_domain     7231..8388
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2559_0018"
                     /evalue="4.10E-39"
                     /label="ctg1_2559"
                     /locus_tag="ctg1_2559"
                     /protein_end="403"
                     /protein_start="17"
                     /score="134.6"
                     /tool="antismash"
                     /translation="LMAFCGVLIETAMNVTFPTLMKQFQVNTGTIQWLTTGYLLVVSII
                     VPISGFLKRRFTTMQLFLTATAFFILGLAICSVANDFALLLIGRLIQGCGTGIALPLMF
                     NIILEQAPLDKIGFLMGIGTLVTAIAPALGPTYGGVLVDLNWHLIFIFLLVVMVIALFL
                     GLFSITQVTKPVHVHLDVIAWLLIAIFFAGAILGLNRIENAPGQAAIYGVVAILGLVGY
                     AWRSLHVKEPLINLRLLKNWSFDWHVVTFLIIQIINVGFAFVLPNYLQLVNHTSSFTAG
                     LLLLPGAALGACMAPMSGNLYDNLGPGKPIFIGLALQLVGILLLLATALTATPVILMLG
                     YAAVMLGTGFAMGNIMTSGQAQLTQTETTDGNAIFNTMQQFAGALG"
     CDS             complement(8713..10173)
                     /locus_tag="ctg1_2560"
                     /transl_table=11
                     /translation="MTDKLTTGEGQAWADNNHSLTAGERGPVLLQDYQLLEKLAHFNRE
                     RIPERVVHAKGAGAKGVFKLTHDMKAYTKADLFNGVGKETPILLRFSQVAGESGYPDTI
                     RDVRGFALKFYTQAGNYDIVGNNTPVFFVNDPLKFPDFIHSQKRDPRTHRRDNNMQWDF
                     WAHSPESTHQVTYLMGDRGNPASYRTMNGYGSHTFKWVNAQGEAYWVKYHFISQQGVQN
                     MTDEVAVKIAGTDTDYLQNDLFSAIETGNFPKWTVYVQILPYQEGLDYKYDIFDVTKVV
                     SHHDYPLIEVGEFTLNENPENYFTDVEEAAFSPANFVPGIEASPDKLLQGRLFGYKDAE
                     RYRLGANYEQLPVNRPLNPVHNYARDGFMAAKQDRSVNYEPNAHGGPEEDHSARIHQDA
                     VNGNIGNYKPYDEDNFSAAGRLYRFMSEDERTRLVTTIVTNLKQVTSLEVRILAAHNFY
                     QADPEYGSRIAEQLGLRMEDVKAGKTEA"
     PFAM_domain     complement(8758..8943)
                     /aSDomain="Catalase-rel"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06628.14"
                     /description="Catalase-related immune-responsive"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2560_0020"
                     /evalue="3.10E-18"
                     /label="ctg1_2560"
                     /locus_tag="ctg1_2560"
                     /protein_end="472"
                     /protein_start="410"
                     /score="65.8"
                     /tool="antismash"
                     /translation="DEDNFSAAGRLYRFMSEDERTRLVTTIVTNLKQVTSLEVRILAAH
                     NFYQADPEYGSRIAEQL"
     PFAM_domain     complement(9022..10158)
                     /aSDomain="Catalase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00199.21"
                     /description="Catalase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2560_0019"
                     /evalue="8.20E-186"
                     /label="ctg1_2560"
                     /locus_tag="ctg1_2560"
                     /protein_end="384"
                     /protein_start="5"
                     /score="617.8"
                     /tool="antismash"
                     /translation="TTGEGQAWADNNHSLTAGERGPVLLQDYQLLEKLAHFNRERIPER
                     VVHAKGAGAKGVFKLTHDMKAYTKADLFNGVGKETPILLRFSQVAGESGYPDTIRDVRG
                     FALKFYTQAGNYDIVGNNTPVFFVNDPLKFPDFIHSQKRDPRTHRRDNNMQWDFWAHSP
                     ESTHQVTYLMGDRGNPASYRTMNGYGSHTFKWVNAQGEAYWVKYHFISQQGVQNMTDEV
                     AVKIAGTDTDYLQNDLFSAIETGNFPKWTVYVQILPYQEGLDYKYDIFDVTKVVSHHDY
                     PLIEVGEFTLNENPENYFTDVEEAAFSPANFVPGIEASPDKLLQGRLFGYKDAERYRLG
                     ANYEQLPVNRPLNPVHNYARDGFMAAKQDRSVNYEPNAH"
ORIGIN
        1 aatgccacga atgctgacga aatcaatcaa gccttcgaca ccggcaaaac caacatcgac
       61 aacgcccacc agccgggcac cgcagtcgat gatcaaaaag ctaatcaaaa gaaggcactg
      121 gatgatattg ctgccaacgt caaaaaagcc attcaagacg acccaacttt gacgacggct
      181 gagaagcagc aacaaaccgc caacgttgac aaagcactca aagatgctaa agacgcgatt
      241 gatgcggcca aagatgccga cagcatcaac caggcatttt ctgacggcaa gacaaacatc
      301 gaaaaagccc atcagcctgg gcaaacactt gatgaccaaa aaaataatca aaagaaagcc
      361 cttgatgaca aagctatcaa gattaagcaa gccattcaag gcgacccaac cctgacgact
      421 gctgagaaaa accagcaaat tgccgaggtc gataaagcgg tcaaggatgg caaagacgcg
      481 attgacgccg ggaccaacgc tgacgagatc aacaaggcat tcacggatgc caagaataac
      541 gttgaccaag cccacaaacc tggcacggct gtcgatgatc aaaaggatgc ccagaagaag
      601 ttactcgatg aagaagcggc caaagttaaa caagacatca aggacgatcc aaccttaacc
      661 actgccgaaa agcagcagca aagtgaaaac gttgacaagg tgcgcaaaga tggccaagct
      721 gccattgatg ccgcgaccaa tgccgacgac atcaacaaag cgtttgaaac cggcaaagtg
      781 aacatcgata acgcccatca accgggtaaa acgctcgatg agcaaaaagc cgctcagaaa
      841 aagtcacttg atgaagaagc ggccaaagtt aagcaggaca tccaaaatga cccaaccctg
      901 acgacaaccg aaaagcaaca acaagccgaa aacgttgaca aggcgcgcaa agacggccag
      961 gccgcgattg acgctgccac gaccccggat gaagtcaatc aggcttttga aactggcaaa
     1021 gtgaacattg acaacgctca ccagccgggc acgtcccttg acgatcaaaa ggctgcacag
     1081 aagaagtcac tggccgatga agccacgaag gttaagcaag cgatccaaga cgacccgacg
     1141 ctgacaactg ccgaaaagca gcagcagagc gaaaacgttg acaaagcctt cctggacggc
     1201 caaaaagcaa tcgatcaagc gcaagatgcc gacagcgtca acacggcatt tgcaaccggc
     1261 aaagctaaca ttgacgccca gcaccaacct ggtaaatctc tagccgatca acgcttgact
     1321 gccactaccg aaattgacaa agaaacggct aaagtcaagc agcagatcga caacgaccct
     1381 ctgctgactg atgctgaaaa agccgatcaa aaggctaagg tggatcacga agcagctctg
     1441 gctaaggaag ccctagcaaa agctatggat gctgacgcct taaatgccgc gcttgctgac
     1501 ggcatcaaga aaattgacgc ccagtacgtg ccgggcacag ccaaaacgcc aactcctgat
     1561 caaggaccaa aaccgctgac cgtcgatccg caaccgacga caacgcggcc actatcaacc
     1621 acgcaaacgc caacctcccc attgccgcga accggtgaca aaccagcaac cggcttagct
     1681 gccctgggtg ccttcatcct aagcatgttc ggcttcgcgc tgaccggtaa aaaacgcaaa
     1741 cgttcttaaa gtaaaaatca atctggatga tgtaattaga aagtagcgcc cgcaattcct
     1801 ccatgagtaa aacatcaagt cccgcgatcg agaagtccga aaagacactc gctcgcgggg
     1861 cttgttttat tgattataaa gaagttacct aagacatgtt gtttgttatt cgagaaaggg
     1921 aggctttgag acatatgaga tacgcttaac atattggcct ttgtgctgga tggatgcaaa
     1981 tttccgcgtt gtatcataac cttgaacaaa ctttaaagtg tatgaaagtt tttgcccatt
     2041 tttcgagtaa atttcaatgt tccgataagt tcgtgtcctc aagggaactt tggcatagct
     2101 tgtttcttcg ctgataaaag gattgacgcg gtcagtcaat tcgttgtgga ttgagagcaa
     2161 cgctaccaca cttacaatga caagtacact aacgcctact aatatctttt ttcctcgagt
     2221 cattgcttgt ttacctcctt gttctgtaaa tctccatcaa gaatttgaat gacgtaatca
     2281 cacttttgcc aaacttcctg cgaatgagtc gcgattatga tagtagcttc tggcccaaag
     2341 ctattgaata agacacgaag tacaatatcg gtgttttctg ggtcaagaga gccggtcggt
     2401 tcatcagcta aaattacatc tggcttttta agaagtgccc gagcaagcgc aatccgttgc
     2461 tgttcgccgc cgctcagcgt aaacactctt tgattaagag gtagattttc caattctact
     2521 tgagccaaag cttgtttcat agctgaccta gagccacttt tgtttaatct tcgatttgca
     2581 aaaccaattt tcaaattggc ctcaaccgtg ccattctcta ttaagccgaa gttctgaaag
     2641 ataaagccta agtgatcacg ccacatcttt tgcacatttg ctttcgaaac tgcgagtcca
     2701 ttcaactcca ccaatcctga agaaggttcc tcaaggccac ccagtatatt taacaaggtc
     2761 gtcttgcccg aaccactttt tccaataatc gcatagcttt tcccgttttc aaactgataa
     2821 ctaactttat ttagaatcat tttttcccca aaacttttgg atattttcct agcgttaatc
     2881 atatcaaagc cacctaattt ccatgattaa gagtatccac caagcctgat tcagctcgag
     2941 atgccgtgaa tagaataatc aaaatttcaa acatgaggta gaagaatcca taaggcaaga
     3001 tattaatcgc actcttaact gttagcactc caactataag cagggcatca agcaaaccgt
     3061 ttaataccat aaatcgcatt aaaattgatt gattagataa tccaaacacc tttcggattg
     3121 ccattctttg gcgttgatct tttaagaaag taacgctcat aaaagataca gcgaataaaa
     3181 gctgaagtaa agaaagtgat gtgattgcaa ccaaaatgaa tatctgacga accataaatg
     3241 tgttgaaatc agataggcga gtcttggcat tggtaatgcc cgtaatattg ctttccagac
     3301 cgagtttttt aatgtcactc tttaatggtt ttagttcgga gaattgaacc atcccctgtg
     3361 tcatcgttgc ccaataaaaa ttgtcggaga atactttttt gtctataatc acaacaatag
     3421 catttctcga aactgaatct tcaatcgcct tgccaacagt gtaattaaat aagctttgat
     3481 tattcttagt cttgaccacc gtaaattcgg taactctagg aacatcaaaa gaatttggca
     3541 gtctccgctg aaacacaatt agcttattca acttttttaa aaagttattt gtttgatcta
     3601 cgcggttact cggaattaaa accattagtc tcccttgttg aggcgcagag tatgaaattt
     3661 gcgtaccatc ataagcaaga atagggttat atttcaagta agttccattt acaaacataa
     3721 catttccgct cattggttca tcatctctaa catttggatg aaattcctgg aaattcctag
     3781 atatgatcac atttgaatca tcatcaatca tctggtgaga tttcctgctt ataaaattca
     3841 tttgattgtc atttgtttca ttgatttgac caaactggac tgtataaccg ctgtgtctag
     3901 taatccaatg attcattgtc ttgctatctt gcgagtacct caaaaaattg ttgtataagg
     3961 ataccccgtt aatggataca agtattacta gcgagatttt aatcatgtat ccaaaaatca
     4021 tgaaagagcg cgactgtcta gatcctttga tggaggtata tatatctatt aaccaaagag
     4081 ttgcataaga cagaacatcc agtacgaaaa agccagaaac caaaatcaac agcaaaatta
     4141 aaatatataa tgcgaacaat tttaaaccaa gaaacgttag cgatgaagct cctacggcaa
     4201 agataataat cacagccgca gcctctgaac taacaaatac aggtaatcca gcccaccaat
     4261 catgtttaat gattctactc ttagtcatgc cattaacttc cattatggca taggatttaa
     4321 aacggtatat tttttccaat aacatgataa tgaacatcat actaatgatt ccaatggcaa
     4381 ctaacaaaaa attggccgaa accatatccg ctaccgaagc attaatcaac gatgggctat
     4441 agatatgagc tggtaaaccg gcatcagaaa atgcagttgc aagggtcttt agctgtttcc
     4501 ccttcgcatc ggtgtaatac atgccattaa catcttcaag ctgaagtgat cgttgattta
     4561 aaagtccaac attcataccc tttttaattg aatattgcct tttgttctta gggttaaagt
     4621 catacacaat tttgttttga tgttcattga tggtattcag ccgtgcctta atcaaaacaa
     4681 gatctttttc tgttgctttt ttcttcagca attcaaaaac agaattcttg ctccgtttac
     4741 catcccaact ctctacagat attgcgcttg ttgtgtttgg aattgtgtta ttgtcgtatg
     4801 ccttgattgt ttccaagaac aaaagtgcca ccaccactgt cgtcattgca aataataaac
     4861 tcttgataac tcgtaacata caagccacca ccctaactat gaataaaaac ccacagcgca
     4921 agattgacgt tgtgggtcat aggtctttaa tcatccggac aaccgatttt tccatgtgaa
     4981 atatgcacca ttatcaggaa ctatttaacg ttatagaaac tttggtttcc gaaatatgac
     5041 ttttgagcag acgcgcgcgc ctctgtaccc ggagaaatcc aaccacttga tgcgctgtat
     5101 gctcccttaa cagctgcact gtgtgtcctg ctattatggg aataatacga ccaaacgtag
     5161 gtcgaaccaa cgccgtagtt ccaagtccca ccttgcacat caactgtata agcaagaact
     5221 ggaactgcgg aaactcctat agtcgcagca gcaagggcac tgacaataac tgactttatc
     5281 ctcatgacca tatcctcctc aagatttaag ttgagtgaca ataattcaac aaatactggg
     5341 tatcttcaaa ttaacatttt gcgacctttc tgctcgcata ttcgaaaatc gaagtgtaca
     5401 tttaagaaaa cgaacagagc tccgcaaaaa tggggtcgtg cttttaattc acttcaacca
     5461 cagtcatgat gagctaccct tttgaagact ccagatatac taacgtcatc accataaagc
     5521 tgtttagagc tatccctcct cccgtttatg cagaaatcat atgacgcccc tttaaaaaaa
     5581 caattttttt gacactttga ttgcatatat gaaattttgg aagggtgaac ccccgtgaca
     5641 tatacattct cgaatttcgg atttttactc gcggctatgc gtaagcggcg acgactaaga
     5701 atgacagaca ttgcggacaa tacaagtttg agtacaatct caagatttga acgaggcaac
     5761 cagaatattt ctctgagcct tgcaagagaa ttgtttgaac gtgtacacgc ctcactgcct
     5821 gaaaccgccg ctcttgtgga taactcaacc ccagtttctg acatgtggcg gagattgaat
     5881 gaggctgcac tcaccgaaga cgtacttatg cttgaaaaag aaatcacagc gttcgaaaca
     5941 atgcatgaca cggtcagttc aatgattgtc atcgttctca aaacttatcg aagtatgttc
     6001 aatcatgaag atctggattg gggtcattcg atttcccctg ttattcgata tctgctcggc
     6061 aatggtcgct ggttcctgtt cgaattccaa ctatttgctg cttcaattta tttggccagc
     6121 cctaaagaca gcaagcgctg tttgattaga gctattcatg aaattggata cactaattcc
     6181 aatatctttc aagagccatt taccactggt ctgttttatg cagcagtatc ggcaattgaa
     6241 aaaagtgact tatcctctgc taacgttttg ctaggcaact tacgcggcct tgctcccaca
     6301 acagacacaa tttttcttaa gtatcgcatc agaatggttg aagcagcatt gaggtactcg
     6361 cttcgtgacg atcctcgtga atacagaaat attgtggata tgcttacatt tctgcacaca
     6421 attggcgctg ataattactg cgaggccgac cagcgttggt taaaaagaat gggcattgag
     6481 attgacttga atcttgatta gataacccgc aaaaattctt tgaacgctcg aatgaataat
     6541 aattatttgc atttaagagc atataaaagt taaaagcgtt gtgaatagac tcgtaaaaat
     6601 ggccatttac ccatttacct ccgctaattt tctcgccatc acattcttca gttgctctag
     6661 cgccgtcatc acgacatccg cattctcacc caaagcttcc cgcaaaaaag catcattctg
     6721 ttgaaagtac gcacgaatat gcgccgcatc atgttgcgcc ttaggggtta gctgaatcgc
     6781 tttataccgg gcgtcctctt ttgatggcgt tcgaacaatc agcgctttac gttccataag
     6841 ctgtaacagt gccgtggccg atgacttttg aatattgaat tcccgctcaa catcggtttg
     6901 gtaaagactg cggtgcgaat cgttgcgtgc caaaaaatcg atgatgctca tctgtacctg
     6961 cgtcaatccc atttgcttgg cctcgcgatc tgcatatcgt tgcagatcgt tattcagttt
     7021 cttgaccaag atacctatcg aatcagtcat tatatcctcc attatctgaa ttactgctgg
     7081 tccaaaacca gccatctgct taaataactt gctttcagaa aaataagtcg ctatagtagc
     7141 atatagttct atatagaact atacacaacg gaggttttta tgacaagaaa agtatcagct
     7201 aaattgtatc tctcgattct cgccactggc ctcatggcgt tttgcggtgt cctcatcgaa
     7261 accgccatga atgtcacctt cccgacttta atgaaacaat ttcaggtcaa tacaggcacg
     7321 attcaatggc taaccactgg gtatttgtta gtcgtgtcaa tcatcgtccc tatttccgga
     7381 ttcttaaaac gccgcttcac caccatgcag cttttcttaa ccgcaacggc ttttttcatc
     7441 ctcggcttag ccatttgtag tgttgcaaat gattttgcgc ttttactgat tggtcggctg
     7501 attcaaggct gcggcaccgg gattgcctta cctctaatgt tcaatattat tctggaacag
     7561 gcaccgctgg ataaaatcgg gtttttgatg ggtattggca cgttggtaac ggctattgcg
     7621 ccagcactcg ggccgactta tggcggggtt ttggtggatc taaattggca tctcatcttt
     7681 attttcctgt tagtcgtcat ggtgattgcc ttgtttctcg ggctgttttc gattacgcaa
     7741 gtcaccaagc ccgtacacgt tcatctagac gttatcgcat ggctcttgat cgcgatcttt
     7801 tttgctggcg ccattttagg ccttaatcgc atcgaaaacg cgcccggcca agctgcaatt
     7861 tacggtgtgg ttgccatctt ggggctcgtt ggctatgcat ggcggtcact gcatgtcaaa
     7921 gagcctttaa tcaatctgcg tttgttgaaa aactggtcat ttgactggca tgttgtcacc
     7981 ttccttatca ttcagatcat taacgtcggc tttgcctttg tcttgccgaa ctatctgcaa
     8041 ctcgtcaacc atacgagttc atttacggca ggcttgctac tgctacccgg tgcggcatta
     8101 ggcgcttgca tggcaccgat gagcggcaat ttgtatgaca atctaggccc cggcaagccg
     8161 atttttattg gcttagcctt acaactggtc ggtattctgt tgttactggc caccgcctta
     8221 accgcaacgc cggtcatctt gatgttaggt tatgcagcgg taatgctagg cactggcttt
     8281 gccatgggga acatcatgac aagcggccaa gcccagctaa cccaaacgga aacaaccgat
     8341 ggcaatgcaa ttttcaatac catgcagcaa tttgccggtg ccttgggaac cgcgtgtgta
     8401 tctttgattg ttgccttggc gcaagtgcct aagaccacgg cacacacaac tgcggttgga
     8461 gcgttacacg ccttttggtt cttattaatc ctggcgatca tcggtgatct tgcgattgcg
     8521 atcggcttaa aaaccagaca tgcccaaaac caggccgcaa gtcacgatgc ttaatcgtca
     8581 tatcggctaa tctcgaaacc taaaaaggct gagatgaaaa gtctccctgt tgaaactgaa
     8641 caggtgtgac tttttatctc agctttttct tttgctatca tttgctgatg cttagttgca
     8701 caaatgccgg ctttaagctt ctgttttacc cgccttcaca tcttccatcc gcagcccgag
     8761 ttgttcggca atgcgactgc cgtattcagg gtcggcttgg taaaaattat gcgcggccag
     8821 gatgcggact tccagactgg tcacttgctt gaggttggtg acaatcgtgg tgactaggcg
     8881 ggtgcgctcg tcttcactca tgaaccgata aaggcggccg gctgctgaga agttatcctc
     8941 gtcgtaaggc ttatagttgc cgatgttgcc attgacagca tcttgatgga ttcgggcgct
     9001 gtggtcttct tcaggaccgc cgtgtgcatt aggctcgtag ttaaccgacc gatcctgctt
     9061 ggcagccatg aaaccatcac gcgcataatt gtgcaccggg ttcaacggcc gattgaccgg
     9121 caactgctcg taattggccc cgagtcgata gcgctccgca tccttgtaac caaagagccg
     9181 tccttgcagc agcttatccg gagatgcttc aatccccgga acaaagttag ctggcgaaaa
     9241 ggccgcttct tcgacatcag taaaatagtt ttccggattt tcattcaggg taaattcgcc
     9301 aacttcaatc agcggataat cgtggtgaga aaccactttg gtgacatcga aaatgtcgta
     9361 cttataatcc aatccctcct gatacggcaa aatctggaca tagactgtcc actttgggaa
     9421 gttccctgtt tcaatggcac taaacaagtc attttgcaga taatcagtat cggtcccggc
     9481 tattttgaca gctacttcat ccgtcatatt ctggacgcct tgttggctga tgaagtgata
     9541 cttaacccag taagcctcgc cttgtgcgtt gacccactta aaggtgtgac tgccataacc
     9601 gttcatggtg cgatagctcg cgggattgcc acggtcgccc atcagataag tcacttgatg
     9661 ggtgctttcc ggtgaatgcg cccagaaatc ccactgcatg ttgttatcgc gccgatgcgt
     9721 gcgcggatcc cgcttttgcg aatgaataaa atcaggaaac ttcaacggat cattgacgaa
     9781 aaagaccggc gtgttgttgc cgacgatgtc ataattaccg gcttgcgtgt aaaacttcag
     9841 cgcaaacccg cgaacatcgc gaatcgtgtc gggatacccg ctttcaccag caacctgcga
     9901 gaaccgcaat aaaatcggcg tttctttgcc aacgccatta aacagatccg cctttgtgta
     9961 cgccttcatg tcatgcgtca acttgaacac acctttggca cctgcgcctt tcgcatgcac
    10021 aacacgttcc ggaatacgtt cccggttaaa atgtgccaat ttctccagca attgataatc
    10081 ctgcaacaac accggcccac gttcgccagc ggtcaaacta tgattattat ccgcccacgc
    10141 ctgaccttcg cctgtggtta gtttatctgt cattaaaaat ccctcctgag cgtgaaccgg
    10201 cgcggttaga agtcgaagtg taagtggcct tgagcgtgat ggcccggtct tggccattgc
    10261 gatcaaggtc cttacacgca gactt
//
