LOCUS       NZ_AP012544.1          15564 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AP012544.1 Lacticaseibacillus casei DSM 20011 = JCM 1134 = ATCC
            393 chromosome, complete genome.
ACCESSION   NZ_AP012544
VERSION     NZ_AP012544.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:24:38
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2277997
            Orig. end    :: 2293561
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1035
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     229.4; E-value: 9.1e-70)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2231"
                     /transl_table=11
                     /translation="LITACSGIVLNDWLTCSCNLRISFIRQTGYKVSEVSLGTWQLGGK
                     WGAPFDAKVARETLEEAYAHGVNFFDTADGYQGGESEKMVGAFVKQHPDVHFTTKIGRK
                     EEPLTAEHFDPDHVRRYVDESLQNMGLDSLDIVLLHCPPMQVYYQPETFFALDVLQKAG
                     KIKHYGVSIERAEEGIKALDYDTAVVEVIFNMFRLRPAETFFPLAKQHDVGILARVPLA
                     SGLLTGKFDENTKFAPTDQRANNRHGEHFSKGETFSGVDYLTGVKAARELKERLGSDNL
                     AATALRFILMYDAVSAVIPGASNPTQIERNTDAADVPPLTPEQMAVVKDVYDRLIKNPV
                     GYEW"
     protocluster    1..15564
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2282177:2289335]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4181..11338
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..15564
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15564
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     103..996
                     /aSDomain="Aldo_ket_red"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00248.23"
                     /description="Aldo/keto reductase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2231_0001"
                     /evalue="9.50E-59"
                     /label="ctg1_2231"
                     /locus_tag="ctg1_2231"
                     /protein_end="332"
                     /protein_start="34"
                     /score="198.9"
                     /tool="antismash"
                     /translation="VSLGTWQLGGKWGAPFDAKVARETLEEAYAHGVNFFDTADGYQGG
                     ESEKMVGAFVKQHPDVHFTTKIGRKEEPLTAEHFDPDHVRRYVDESLQNMGLDSLDIVL
                     LHCPPMQVYYQPETFFALDVLQKAGKIKHYGVSIERAEEGIKALDYDTAVVEVIFNMFR
                     LRPAETFFPLAKQHDVGILARVPLASGLLTGKFDENTKFAPTDQRANNRHGEHFSKGET
                     FSGVDYLTGVKAARELKERLGSDNLAATALRFILMYDAVSAVIPGASNPTQIERNTDAA
                     DVPPLTPEQMAVVKDVY"
     CDS             complement(1322..2677)
                     /locus_tag="ctg1_2232"
                     /transl_table=11
                     /translation="MTSKSNQAAQGNPPLSEKHHMQIPWYDVIVSEERQADHATLEERA
                     SLVGRVGIMLLACGTGAWRVREAMNTVARALRMSCSADIGLISLSYTCFSNNHAYSEVL
                     SLPQSGVNTDKLDALERFVREFDAQYAKETVRDIHHRLDQIQKMSGNYDPLRAGLAAAL
                     ACCAFVFLLGGGPIEMICCFVGAGIGNWLRGIMIRRNWTLLACIGVSVAVACLVYFLVF
                     QGLEMSLGIAARHEAGYIGAMLFVIPGFPFITSMLDISKQDMRSGMERLLYALMITIVA
                     SLVGWLVAMVVHLRPENFADLGLNPALLLIFRLIASFCGVFGFSVMFNSPRRMAVQAGL
                     IGSVANTLRLELVDLNTIPPAAAAFIGALVAGLIASAINRVDGYPRISLTVPSIVIMVP
                     GLYIYRAVYNIGLNNIGVGAEWMTRAALIIMFLPLGLFTARLIMDSRWRESD"
     PFAM_domain     complement(1355..1738)
                     /aSDomain="ThrE_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12821.9"
                     /description="Threonine/Serine exporter, ThrE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2232_0003"
                     /evalue="2.10E-20"
                     /label="ctg1_2232"
                     /locus_tag="ctg1_2232"
                     /protein_end="441"
                     /protein_start="313"
                     /score="73.3"
                     /tool="antismash"
                     /translation="LIASFCGVFGFSVMFNSPRRMAVQAGLIGSVANTLRLELVDLNTI
                     PPAAAAFIGALVAGLIASAINRVDGYPRISLTVPSIVIMVPGLYIYRAVYNIGLNNIGV
                     GAEWMTRAALIIMFLPLGLFTARL"
     PFAM_domain     complement(1802..2539)
                     /aSDomain="ThrE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06738.14"
                     /description="Putative threonine/serine exporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2232_0002"
                     /evalue="1.30E-58"
                     /label="ctg1_2232"
                     /locus_tag="ctg1_2232"
                     /protein_end="292"
                     /protein_start="46"
                     /score="198.3"
                     /tool="antismash"
                     /translation="LVGRVGIMLLACGTGAWRVREAMNTVARALRMSCSADIGLISLSY
                     TCFSNNHAYSEVLSLPQSGVNTDKLDALERFVREFDAQYAKETVRDIHHRLDQIQKMSG
                     NYDPLRAGLAAALACCAFVFLLGGGPIEMICCFVGAGIGNWLRGIMIRRNWTLLACIGV
                     SVAVACLVYFLVFQGLEMSLGIAARHEAGYIGAMLFVIPGFPFITSMLDISKQDMRSGM
                     ERLLYALMITIVASLVGWLVAMVV"
     CDS             complement(2790..3314)
                     /locus_tag="ctg1_2233"
                     /transl_table=11
                     /translation="MQQTIAAEQLKVQQAIQEGESKQTALKDQRNNYQVKAPAAGILHL
                     EAALSGNKYISTGTVLAQILPDLAKQKEADLKMAISPAEVMSLKRGQNVRLRIARNVPM
                     PMTITGRIYAVDVAPTVNPKTGNYFKAQARVHLSKTHQQSVYYGIAGEATVITGTKTYW
                     QYFVDKMFNRQ"
     PFAM_domain     complement(2898..3212)
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2233_0004"
                     /evalue="1.20E-08"
                     /label="ctg1_2233"
                     /locus_tag="ctg1_2233"
                     /protein_end="139"
                     /protein_start="34"
                     /score="35.6"
                     /tool="antismash"
                     /translation="VKAPAAGILHLEAALSGNKYISTGTVLAQILPDLAKQKEADLKMA
                     ISPAEVMSLKRGQNVRLRIARNVPMPMTITGRIYAVDVAPTVNPKTGNYFKAQARVHLS
                     K"
     CDS             complement(3489..4169)
                     /locus_tag="ctg1_2234"
                     /transl_table=11
                     /translation="MIDLKKLETTEFYNHHYRNFSTMIILPTTILFIGLLLFFIFAKRE
                     VTVTTAAEIAPVKTAVTIQGTAANRIVTNHMKEGKRVKKGETLLVYHDVANPAQLKVLN
                     QQLATLKDQKDQLDTLNRSIAANKDLFTTADKFGYQQQVRDYFNQRRVYELESEAVNAT
                     QNVANAKNKEIVQLLQTSMQASEDKIAAIRKAQNAIRTDQPLKADHAYGYLYGQYQAEA
                     KNTE"
     CDS             complement(4181..5806)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 296.8; E-value:
                     5.5e-90)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2235"
                     /sec_met_domain="TIGR01193 (E-value: 4.4e-253, bitscore:
                     839.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VISIVGSYFLQSIIDTYIPSAMRTTLGMIATGLILAYILQSVLTY
                     GQNFLMAVLGQRLSIDVILGYVRHLYELPMSFFATRRTGEIVSRFSDANKIIDALANTI
                     MTLFLDVWIVLILGIVLGIQNTTLFLVSLIAVPCYLVIVFAFQRSFNRLNQETMESNAI
                     LSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYAKADQLQQAIKGLLKLV
                     LNVVVLWIGASLVMANKMSLGQMLTFNALLSYFTNPLESIINLQPKLQMAKVANNRLNE
                     VYLVESEFKEQRHLTDRSLIDGAIIVNDVSFKYGFGQDILKHVHLEVPANAKYTIVGMS
                     GSGKSTLAKLLVGFYPVETGRGKITFNGAQIDDVALTTLRQYIEYVPQEPFIFSGSVME
                     NLTLGSRADLTQAQLEDACAVEEIATDIMNLPQMWQTKLTESGSILSGGQKQRLAIARA
                     LLSPAKVLIFDESTSSLDTITERRIVDRLLAMKDRTIIFVTHRLTIAAKTEQIVVMDHG
                     EIVEQGNHAELLAKKGYYARLVSE"
     aSDomain        complement(4187..5806)
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2235_0001"
                     /evalue="6.90E-253"
                     /identifier="TIGR01193"
                     /label="ctg1_2235"
                     /locus_tag="ctg1_2235"
                     /protein_end="540"
                     /protein_start="0"
                     /score="839.2"
                     /tool="antismash"
                     /translation="VISIVGSYFLQSIIDTYIPSAMRTTLGMIATGLILAYILQSVLTY
                     GQNFLMAVLGQRLSIDVILGYVRHLYELPMSFFATRRTGEIVSRFSDANKIIDALANTI
                     MTLFLDVWIVLILGIVLGIQNTTLFLVSLIAVPCYLVIVFAFQRSFNRLNQETMESNAI
                     LSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYAKADQLQQAIKGLLKLV
                     LNVVVLWIGASLVMANKMSLGQMLTFNALLSYFTNPLESIINLQPKLQMAKVANNRLNE
                     VYLVESEFKEQRHLTDRSLIDGAIIVNDVSFKYGFGQDILKHVHLEVPANAKYTIVGMS
                     GSGKSTLAKLLVGFYPVETGRGKITFNGAQIDDVALTTLRQYIEYVPQEPFIFSGSVME
                     NLTLGSRADLTQAQLEDACAVEEIATDIMNLPQMWQTKLTESGSILSGGQKQRLAIARA
                     LLSPAKVLIFDESTSSLDTITERRIVDRLLAMKDRTIIFVTHRLTIAAKTEQIVVMDHG
                     EIVEQGNHAELLAKKGYYARLVS"
     PFAM_domain     complement(4388..4846)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2235_0006"
                     /evalue="6.10E-29"
                     /label="ctg1_2235"
                     /locus_tag="ctg1_2235"
                     /protein_end="473"
                     /protein_start="320"
                     /score="101.4"
                     /tool="antismash"
                     /translation="LKHVHLEVPANAKYTIVGMSGSGKSTLAKLLVGFYPVETGRGKIT
                     FNGAQIDDVALTTLRQYIEYVPQEPFIFSGSVMENLTLGSRADLTQAQLEDACAVEEIA
                     TDIMNLPQMWQTKLTESGSILSGGQKQRLAIARALLSPAKVLIFDESTS"
     PFAM_domain     complement(5030..5806)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2235_0005"
                     /evalue="6.80E-60"
                     /label="ctg1_2235"
                     /locus_tag="ctg1_2235"
                     /protein_end="259"
                     /protein_start="0"
                     /score="203.1"
                     /tool="antismash"
                     /translation="VISIVGSYFLQSIIDTYIPSAMRTTLGMIATGLILAYILQSVLTY
                     GQNFLMAVLGQRLSIDVILGYVRHLYELPMSFFATRRTGEIVSRFSDANKIIDALANTI
                     MTLFLDVWIVLILGIVLGIQNTTLFLVSLIAVPCYLVIVFAFQRSFNRLNQETMESNAI
                     LSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYAKADQLQQAIKGLLKLV
                     LNVVVLWIGASLVMANKMSLGQMLTFNALLSYFTNPL"
     CDS             complement(5898..6950)
                     /locus_tag="ctg1_2236"
                     /transl_table=11
                     /translation="MQKQDSTHRQKGQHLTSLERGKVAGFRQAGKSNRWIAAEIGVCPQ
                     TINNEIKRGTVDQVKKSNGKRVYHRQYLPEAAQARYETARLSCHRPDKFASVQVFLAWY
                     VQRAKQDKWSPDASIGYAKRHKLFTPEELVCASTLYQYIDDQRLEIRNIDLLEKTKRKT
                     SHQHHTKAKRLAGRSIEERPKVVERRRQFGHWEMDTIVGKRNGKESVILTLIERKTRCQ
                     LLRLIEGRDADSVSYALRGIKREWGACIKTITADNGPEFTALNTAFAGTETEIFYAHPY
                     TSCDRGTNEAHNRMIRQDFPKGMSLDDISPSQVQATQDRLNQLPRKQQGYCTPQQNFEA
                     EARRVRRMAQ"
     PFAM_domain     complement(6789..6920)
                     /aSDomain="HTH_38"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13936.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2236_0007"
                     /evalue="2.90E-09"
                     /label="ctg1_2236"
                     /locus_tag="ctg1_2236"
                     /protein_end="54"
                     /protein_start="10"
                     /score="36.6"
                     /tool="antismash"
                     /translation="KGQHLTSLERGKVAGFRQAGKSNRWIAAEIGVCPQTINNEIKRG"
     CDS             complement(7021..7647)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2237"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.5e-42, bitscore:
                     139.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKYKFKLGQATYYKRYYTPQVDERDCGVAALNMLLKFHKSDYSL
                     AHLRQLAKTDQEGTTALGIVRAAQELHFETKAVKADMTLFNLDDVSYPILVHVLKRGEL
                     LHYYVVFKATKDHILIGDPDPSVAMTWLSKDEFAKEWSGVAIFIAPEPQYQPRKEDKGS
                     LFAFVPLLARQKVIIANIIVAALLITVISAHFRIKLATVSKFFGQ"
     PFAM_domain     complement(7192..7602)
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2237_0008"
                     /evalue="5.70E-41"
                     /label="ctg1_2237"
                     /locus_tag="ctg1_2237"
                     /protein_end="152"
                     /protein_start="15"
                     /score="139.5"
                     /tool="antismash"
                     /translation="RYYTPQVDERDCGVAALNMLLKFHKSDYSLAHLRQLAKTDQEGTT
                     ALGIVRAAQELHFETKAVKADMTLFNLDDVSYPILVHVLKRGELLHYYVVFKATKDHIL
                     IGDPDPSVAMTWLSKDEFAKEWSGVAIFIAPEP"
     CDS             complement(7964..8110)
                     /locus_tag="ctg1_2238"
                     /transl_table=11
                     /translation="MNDKKSGQKEAIISDYSLSQVRGGANRVISQPFKGLKNWIGELFR
                     GRH"
     CDS             8277..9578
                     /locus_tag="ctg1_2239"
                     /transl_table=11
                     /translation="MVSLPSHIYFFINWPIFFFGVGFLSYIFFGLIRPLHVASWSIIGT
                     SLSLFLSTYGEIGFCLIYAWYISRTNASSDKFWVFIFMEVNLIIITIQTCIIRIFAAAG
                     TKQLTLISVGTTLILTSTLAAIVISLLVKKRSQLDQLRTLIKEQNHLQKSIIIYTGATC
                     VSLYCFEAISNLVNIGIMLDLLILGIFTLSVIINLYSLFLILKSFSYYVELTWIKRAEA
                     SQRAYYTTLSQQQKTTNKLLHDYKNLLASLQLSLQQSSSTISPDTQAILSRAQASLNQA
                     ELSKSSFTAIKSDPLKSLLYLKWAESMNHNIIMNVQTKGIIHPLESGLGFAIIRALGIL
                     IDNALEETVRIKHHRFDVTLIALKQGLEVSVMNDVGPDFNLADLEKKDFTTKGDGHGNG
                     LSIINELMQQNKNILIRKSVISQQLKITLFIGDS"
     PFAM_domain     9273..9518
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2239_0009"
                     /evalue="5.50E-07"
                     /label="ctg1_2239"
                     /locus_tag="ctg1_2239"
                     /protein_end="414"
                     /protein_start="332"
                     /score="29.5"
                     /tool="antismash"
                     /translation="IIRALGILIDNALEETVRIKHHRFDVTLIALKQGLEVSVMNDVGP
                     DFNLADLEKKDFTTKGDGHGNGLSIINELMQQNKNIL"
     CDS             9580..10386
                     /locus_tag="ctg1_2240"
                     /transl_table=11
                     /translation="MITNRTTLKIFILEDDATFLRFIEKTLRNYIMIEELHAEIKIATQ
                     SATDLLNAIDLQQINDSFFLLAIDIPGSSINGIDIANIVRKHSLYADIMFITSHTEQAL
                     AILSQKILPLDLVDKSVPAEVETRLRTNLVQGIKRLRSRQLESPRLFSYQIGANLFSLP
                     LDDVLYIQTVLGTPSTLELHAKHETTTFPGNLKEVSTRYPTLFRCHRSFLLNPLHVHKL
                     NASGRFVYMDNQDKLDVSIRKVSALRKLMAAANRSHAEANNLADDA"
     PFAM_domain     10054..10332
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2240_0010"
                     /evalue="3.30E-16"
                     /label="ctg1_2240"
                     /locus_tag="ctg1_2240"
                     /protein_end="251"
                     /protein_start="158"
                     /score="59.4"
                     /tool="antismash"
                     /translation="LFSLPLDDVLYIQTVLGTPSTLELHAKHETTTFPGNLKEVSTRYP
                     TLFRCHRSFLLNPLHVHKLNASGRFVYMDNQDKLDVSIRKVSALRKLM"
     CDS             complement(10567..10851)
                     /locus_tag="ctg1_2241"
                     /transl_table=11
                     /translation="MPSKDEIIVAMEKLAIKLSMCHKNSETALFVDRELEVLKTCDGLA
                     FHNKLQYFFNTAPVIKLSDSISFSESEKTFWDAVFEYKQLGNYDWIASE"
     CDS             complement(10915..11154)
                     /locus_tag="ctg1_2242"
                     /transl_table=11
                     /translation="VNSLIWEKMAVFDHRRLKQPLSMWIVQLCLFILLWIISDDAIWQV
                     YAIILIAILSNSYDFLRKLFTMTRAYDRQRNNKE"
     CDS             complement(11117..11338)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2243"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.7e-09,
                     bitscore: 35.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNVQLLANADLAKIAGGSRLGTCGYGTAGAGAVGFLSGASLGSL
                     LGPAGTIAGAIIGGIGSEFAYMGENGCI"
     PFAM_domain     complement(11156..11338)
                     /aSDomain="Bacteriocin_IIc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10439.11"
                     /description="Bacteriocin class II with double-glycine
                     leader peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2243_0011"
                     /evalue="2.10E-07"
                     /label="ctg1_2243"
                     /locus_tag="ctg1_2243"
                     /protein_end="61"
                     /protein_start="0"
                     /score="30.9"
                     /tool="antismash"
                     /translation="MKNVQLLANADLAKIAGGSRLGTCGYGTAGAGAVGFLSGASLGSL
                     LGPAGTIAGAIIGGIG"
     CDS             complement(11458..11619)
                     /locus_tag="ctg1_2244"
                     /transl_table=11
                     /translation="MTNLKDSELCQITGGFLPFAIPVATILGILATDAFNHADQLIDGF
                     KQGWERPW"
     CDS             complement(11648..11845)
                     /locus_tag="ctg1_2245"
                     /transl_table=11
                     /translation="MQQFVTLDDSRLERISGGGTDNFWTYIGMGLGAIARSWAQGGFAT
                     PAMSLGIDVLNELKRKENLP"
     CDS             12087..13139
                     /locus_tag="ctg1_2246"
                     /transl_table=11
                     /translation="MQKQDSTHRQKGQHLTSLERGKVAGFHQAGKSNRWIAAEIGVCPQ
                     TINNEIKRGTVDQVKKSNGKRVYHRQYLPEAAQARYETARLSCHRPDKFASVQVFLAWY
                     VQRAKQDKWSPDASIGYAKRHKLFTPEELVCASTLYQYIDDQRLEIRNIDLLEKTKRKT
                     SHQHHTKAKRLAGRSIEERPKVVERRRQFGHWEMDTIVGKRNGKESVILTLIERKTRCQ
                     LLRLIEGRDADSVSYALRGIKREWGACIKTITADNGPEFTALNTAFAGTETEIFYAHPY
                     TSCDRGTNEAHNRMIRQDFPKGMSLDDISPSQVQATQDRSNQLPRKQQGYCTPQQNFEA
                     EARRVRRMAQ"
     PFAM_domain     12117..12248
                     /aSDomain="HTH_38"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13936.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2246_0012"
                     /evalue="1.30E-09"
                     /label="ctg1_2246"
                     /locus_tag="ctg1_2246"
                     /protein_end="54"
                     /protein_start="10"
                     /score="37.8"
                     /tool="antismash"
                     /translation="KGQHLTSLERGKVAGFHQAGKSNRWIAAEIGVCPQTINNEIKRG"
     CDS             13350..14402
                     /locus_tag="ctg1_2247"
                     /transl_table=11
                     /translation="MQKQDSTHRQKGQHLTSLERGKVAGFRQAGKSNRWIAAEIGVCPQ
                     TINNEIKRGTVDQVKKSNGKRVYHRQYLPEAAQARYETARLSCHRPDKFASVQVFLAWY
                     VQRAKQDKWSPDASIGYAKRHKLFTPEELVCASTLYQYIDDQRLEIRNIDLLEKTKRKT
                     SHQHHTKAKRLAGRSIEERPKVVERRRQFGHWEMDTIVGKRNGKESVILTLIERKTRCQ
                     LLRLIEGRDADSVSYALRGIKREWGACIKTITADNGPEFTALNTAFAGTETEIFYAHPY
                     TSCDRGTNEAHNRMIRQDFPKGMSLDDISPSQVQATQDRLNQLPRKQQGYCTPQQNFEA
                     EARRVRRMAQ"
     PFAM_domain     13380..13511
                     /aSDomain="HTH_38"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13936.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2247_0013"
                     /evalue="2.90E-09"
                     /label="ctg1_2247"
                     /locus_tag="ctg1_2247"
                     /protein_end="54"
                     /protein_start="10"
                     /score="36.6"
                     /tool="antismash"
                     /translation="KGQHLTSLERGKVAGFRQAGKSNRWIAAEIGVCPQTINNEIKRG"
     CDS             complement(14611..15564)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     223.5; E-value: 5.5e-68)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2248"
                     /transl_table=11
                     /translation="MKQVRLGGSNWQASSVALGIMRMNVLSPEKAAIVLDSAYNDGINF
                     IDSADIYGQGKSEEVFGEALKQSGVNRDQLYIQSKIGIVVDPDRSHGSLVFGRRYDFSK
                     EHLLGAVDKILERLQIDYLDSVLLHRPDPLMEVDDVAAAFDELQQSGKVRHFGVSNFNP
                     EQIALLQSGIHQHLLIDQVQFSVAHTGMVNAGMHTNMEDDRSIDHDGSLLPYLQRKQMT
                     LQAWSPFQYGMFEGTFIDSPKFKDLNDELQKVAEHYHTNKNAIAVAWLLRHPVGVQVIL
                     GSMNPEHIKESAAGADITLTRQEWYNIYFAAGNDLP"
     PFAM_domain     complement(14647..15519)
                     /aSDomain="Aldo_ket_red"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00248.23"
                     /description="Aldo/keto reductase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2248_0014"
                     /evalue="2.40E-51"
                     /label="ctg1_2248"
                     /locus_tag="ctg1_2248"
                     /protein_end="306"
                     /protein_start="15"
                     /score="174.6"
                     /tool="antismash"
                     /translation="VALGIMRMNVLSPEKAAIVLDSAYNDGINFIDSADIYGQGKSEEV
                     FGEALKQSGVNRDQLYIQSKIGIVVDPDRSHGSLVFGRRYDFSKEHLLGAVDKILERLQ
                     IDYLDSVLLHRPDPLMEVDDVAAAFDELQQSGKVRHFGVSNFNPEQIALLQSGIHQHLL
                     IDQVQFSVAHTGMVNAGMHTNMEDDRSIDHDGSLLPYLQRKQMTLQAWSPFQYGMFEGT
                     FIDSPKFKDLNDELQKVAEHYHTNKNAIAVAWLLRHPVGVQVILGSMNPEHIKESAAGA
                     DITLTRQEWY"
ORIGIN
        1 ttgataacgg cctgttctgg gattgtcctc aacgactggc taacttgttc ttgcaattta
       61 cgaatatcgt ttattaggca aaccggctac aaagtcagtg aagtttccct cggtacttgg
      121 caactgggcg gcaagtgggg ggcaccgttt gatgccaaag ttgcccgcga aactttggaa
      181 gaagcatacg ctcatggcgt caacttcttt gatactgccg atggttatca aggcggtgaa
      241 agcgaaaaaa tggtcggcgc ttttgtcaaa cagcatcccg acgttcattt cacgaccaaa
      301 atcggccgta aagaagaacc gttgactgcc gagcattttg atcctgatca tgtacgccgc
      361 tatgtcgatg aatcattaca aaatatgggc ttggacagcc tggatattgt cttgttgcac
      421 tgcccgccaa tgcaggtcta ctaccaaccc gagactttct ttgcactgga tgtcttgcaa
      481 aaagccggca agatcaagca ttacggtgtc agcatcgagc gcgcagagga aggcattaaa
      541 gctttggact atgacacggc tgtcgttgaa gtgattttca acatgttccg tctgcgccct
      601 gccgaaacct tcttcccgct ggccaaacaa catgatgttg gcattctcgc tcgcgtccca
      661 ttagcaagcg gcttactgac cggcaagttc gatgaaaaca ccaaatttgc cccgaccgat
      721 caacgagcca acaatcgtca cggcgagcac ttcagcaaag gtgaaacttt ctccggcgtt
      781 gattatctaa ccggcgttaa agctgcccgc gaacttaagg aacgtctcgg ttcagataac
      841 ctcgccgcaa ccgcacttcg gtttatccta atgtatgatg ctgtttcagc cgtcatcccc
      901 ggtgccagca accctaccca aatcgaacgc aacaccgatg ctgcggatgt accgccgctg
      961 acgcctgaac aaatggcagt ggttaaagat gtgtatgacc gcctgatcaa aaatccggtt
     1021 ggatacgaat ggtaacagct taatcactgt tgtcaaaagc tgccgctcac cgatttatat
     1081 cgatgtaagg gtacttttac acgccaccgg agtgtgatca aggccagctc acatgttagc
     1141 taggtggcat caggatttat gcaccactca tcgctgccgg cagctttctt tggcaacagc
     1201 gctgttgcga cataacgatt tgcttcattg ctgacaaatc aaatcattca agcaatcaac
     1261 gcaacaaccc cactttgcca agcaaagtgg ggttgtttgt gtgcttcgga tgactagagg
     1321 ctcaatcgct ttcccgccac cgtgaatcca taatcagacg cgcggtaaat aagcccagtg
     1381 gcaaaaacat gataatgagt gccgcgcggg tcatccattc cgcgccaacg ccaatgttgt
     1441 taagaccgat attatacaca gcccgataaa tataaaggcc cggaaccatg atcacaattg
     1501 atggcacggt cagtgaaatt cgcggatagc catcgacacg attaatcgcc gaggcaatca
     1561 agcctgcgac caaggcaccg ataaacgctg ccgcagctgg cggaatcgta tttaaatcca
     1621 ccagttcaag ccgcaacgtg ttggcgacgg acccgatcaa accagcctga actgccatgc
     1681 gccgcggact gttgaacatc acggagaaac cgaaaacgcc acaaaaacta gcgatgagcc
     1741 ggaaaatcag taaaagtgcc ggattaaggc ctaaatcggc aaaattctct gggcgcaagt
     1801 gcactaccat ggccactaac cacccaacca atgaagcgac aatcgtgatc atcaaagcat
     1861 ataacagccg ctccatgcct gagcgcatat cctgcttgga aatatccaac atactggtga
     1921 tgaacggaaa gcccggaatg acgaacaaca tggcgccgat atagccggct tcatgccgtg
     1981 cagcaatccc caagctcatt tccaggcctt ggaacacaag aaagtaaacc agacaggcaa
     2041 ccgcaacact gaccccgatg cacgccaaca acgtccaatt gcgccgaatc ataatcccgc
     2101 gcagccagtt accgataccc gcaccgacaa aacaacaaat catctcaatc ggaccgccac
     2161 caagcaggaa aacgaaggca cagcaggcca atgccgcggc aagacctgca cgaagcggat
     2221 catagttgcc ggacattttc tgaatctgat caagccggtg atgaatatct cgtaccgtct
     2281 ctttggcata ctgcgcatca aactcgcgca caaatcgttc cagcgcatcc aacttgtccg
     2341 tgttcacacc actttgcggc aacgataaca cttcggaata agcgtggtta ttgctgaagc
     2401 aggtatacga caatgaaatt aacccaatat cagccgaaca cgacatccgc aaggctcgcg
     2461 ccaccgtgtt catggcttcc cgaacccgcc acgcccctgt gccacacgcc agcagcataa
     2521 tgccaacccg gccaacaagc gatgcccgtt cctcaagcgt tgcatgatcc gcctgacgtt
     2581 cttcgctaac gatgacgtca taccaaggaa tctgcatatg gtgtttttct gaaagcggtg
     2641 gattcccctg cgccgcctga ttactttttg acgtcataac ttgtgccaat ccttcttctt
     2701 ataggaatat tcgttttgaa aaatgaaaag aaacattcac tattttagca caactttagc
     2761 tggcttattt taaaatatcg ccgcacttgt tactggcgat tgaacatttt atcaacaaaa
     2821 tactgccaat atgtctttgt tccggtaatg acggttgctt ctccagcgat gccatagtag
     2881 accgactgtt gatgtgtttt agacaagtgt accctagcct gggctttaaa gtagttgccg
     2941 gttttgggat tcacggtcgg tgcaacgtca actgcataaa tccggccggt tatcgtcata
     3001 ggcatcggaa cgttccgggc aattcgtaag cgaacgtttt gaccgcgttt caggctcatg
     3061 acctcggccg gcgaaattgc catcttcaaa tcagcttctt tttgcttagc caagtccggt
     3121 aagatctgtg ctaagacagt gccggtggaa atgtacttgt tgccacttaa agctgcttca
     3181 agatgcaaaa taccagcggc tggtgcttta acttggtaat tgttgcgctg atctttgagt
     3241 gccgtctgtt ttgactcgcc ttcctgaatg gcctgctgca ccttcagttg ctctgccgcg
     3301 atggtttgct gcattttatt ttgcaaagaa gctaactttg cctcattctg acccgtttgt
     3361 tgcgcagaaa gatcagcttg tttttggttg gcgcgttggg ttttcagtgc agcaagcgcc
     3421 tctttttcac ttgttagcag attttgcagc tgtgactggt attgaccttt taaattggcg
     3481 agatttgcct actcagtatt tttggcttcg gcttgatatt gcccataaag ataaccgtaa
     3541 gcatggtcag cttttagcgg ctgatcggtt cggatggcgt tttgagcttt gcgaatcgct
     3601 gctattttat cctcgctggc ttgcatactg gtctgtaaca attgaacaat ttctttattc
     3661 ttggcattcg ccacgttttg agtcgcattc acggcctccg actctagttc gtaaactcgg
     3721 cgttgattga aataatcgcg cacttgttgt tgatagccga acttgtcggc agtggtaaaa
     3781 agatccttat tggcggcaat actccgattg agtgtgtcca attggtcttt ttgatctttt
     3841 agcgtggcca actgttggtt caacaccttt aattgtgcag gattcgctac atcgtgatac
     3901 accagcagcg tctcgccttt tttgacccgc ttgccttcct tcatatgatt cgtcacaatc
     3961 cgattcgccg ctgtcccctg aatggtcacg gccgttttaa ctggggcaat ttccgccgcc
     4021 gttgtcacgg tcacttcgcg tttagcaaaa atgaaaaaga gcaacaggcc tataaacaga
     4081 atcgttgtcg gcaagataat catggtcgaa aaattgcggt aatgatggtt ataaaactcg
     4141 gtggtctcta gtttcttaag atcaatcatc gtcaacctcc ttattcactc accaaccgcg
     4201 cataatatcc cttcttcgcc agcagttcgg catgattgcc ctgctcaaca atttctccat
     4261 gatccatcac cacaatctgt tcggttttag ccgcgatggt gagtcggtgg gtgacaaaaa
     4321 taatcgttcg atctttcatt gctaataacc gatccacaat ccgccgctct gtgatggtat
     4381 ccagactgct agtcgactca tcaaaaatca gcactttggc cggcgacaac aacgcgcgcg
     4441 caatcgccaa acgctgcttc tgcccgcctg ataaaatgct cccgctttcc gtgagcttgg
     4501 tctgccacat ttgcggcaga ttcataatat ccgtggcaat ctcctcaacg gcacatgcgt
     4561 cttcaagttg cgcctgcgtc aaatcggcac gactacctaa cgttaagttt tccatcaccg
     4621 atccggaaaa aataaatggt tcttgcggca catactcgat atattgccgc agcgtcgtga
     4681 gcgccacatc atcgatctgc gcgccattaa aagtgatttt ccccctgcct gtttcgaccg
     4741 ggtaaaaacc gaccaataat ttagccaaag ttgatttgcc tgacccactc atgccgacaa
     4801 tcgtgtattt agcgtttgcg ggcacttcaa gatggacatg cttcaaaata tcctgaccaa
     4861 atccatactt aaaagaaacg tcattcacaa tgatggcgcc atcgatcaag ctgcgatcgg
     4921 tcagatggcg ctgttcttta aactcagatt caaccaaata aacctcattc agccgattat
     4981 tcgccacctt agccatttgc aattttggtt gcaagttaat gatgctttct aacggattgg
     5041 tgaagtatga cagcaaggca ttgaacgtca gcatctgccc caagctcatc ttgttagcca
     5101 tcaccagact cgccccaatc cacaacacca ccacattcaa gacgagtttc agcaaccctt
     5161 tgatagcttg ttgaagttgg tcagctttcg cgtaattgaa tgactttttt aaatacgtaa
     5221 cgaattcacg gtcaacccgt tcataactga ctttttcgcc tgtcagcgac ttaatggtct
     5281 caataccgtt cagatcctca ataatcgatg agctcaaaat ggcattgctt tccattgtct
     5341 cttgattcag ccgattgaaa gaacgttgaa acgcgaaaac aatcaccaag taacaaggca
     5401 ccgcaattaa ggacaccagg aacaatgtgg tattttgaat gcccaaaaca atgcctaaaa
     5461 taagcacgat ccaaacgtca agaaacaggg tcataatcgt attcgccaag gcatcgataa
     5521 ttttattggc atccgaaaac cgcgacacaa tctcccctgt ccgacgcgtt gcaaaaaaag
     5581 acatgggtaa ttcatacaga tgccgaacgt aacccaaaat aacgtcaatc gacaaccgct
     5641 ggcctaaaac cgccatcaaa aagttctgac catacgtcaa aacggattgg aggatgtagg
     5701 cgagaatcaa accagtggca atcattccta acgtcgtccg catggcactg ggaatatagg
     5761 tatcaatgat cgattgcaga aaatacgacc caacaatgct aatcaccgtg acgtaaattg
     5821 caagaacaag ttagccagtc gttgaggaca atcccagaac aggccgttat caaatagaag
     5881 ttgtggcgct agagagacta ctgggccatg cggcgaacgc gccgagcttc ggcctcaaag
     5941 ttttgctggg gtgtgcagta gccctgttgt ttgcgaggca actgattcaa gcggtcttgc
     6001 gtggcctgca cttgactagg gctaatgtca tctagggaca tgcccttagg gaagtcctgg
     6061 cggatcatcc ggttatgtgc ctcgttggtg ccacggtcgc aggacgtgta aggatgggcg
     6121 tagaagatct cagtttccgt cccagcaaaa gcagtattta aggcggtgaa ctcgggtccg
     6181 ttgtcggctg tgatggtctt gatgcaagct ccccattcgc gcttgattcc acgcaatgca
     6241 tagctcacag agtctgcatc tcgtccttcg atcaagcgga gaagttggca acgggtcttg
     6301 cgctcaatca gagtcaagat gacgctctcc ttgccattgc gtttaccgac aatggtatcc
     6361 atctcccagt gaccgaactg cctgcgtcgt tcaacgacct taggccgttc ctcgatactg
     6421 cggccagcca ggcgcttagc cttggtgtgg tgctggtgag aggtcttccg cttagtcttc
     6481 tccaacaggt cgatatttcg aatctctagg cgttggtcgt caatgtactg gtacaaagtc
     6541 gaggcacaaa caagctcttc aggagtaaac agcttgtgtc gcttggcata gccgattgaa
     6601 gcatccggcg accatttgtc ctgcttagct cgctgtacgt accaggctaa gaagacctgt
     6661 acgctggcga acttgtcagg acgatggcag ctcaagcgtg cagtctcgta acgtgcctga
     6721 gcagcctctg gcaggtattg tcgatggtag acgcgcttgc cattactctt cttgacctga
     6781 tctactgtac ctcgcttgat ttcattatta atggtctgcg ggcagacgcc aatttcagca
     6841 gcaatccaac gattggactt cccagcttgg cggaatccgg ccacttttcc gcgctcgagt
     6901 gatgttaagt gctgaccttt ttggcggtgt gtgctatcct gtttctgcat caagacaata
     6961 tcctcttcca ttgtttgtgt aggaacttca atgatacagg atatctgttc ttgatgtttt
     7021 ttattgtcca aaaaattttg agacagtggc taacttgatt ctaaaatgcg cgctaatcac
     7081 cgtgatcaac aaagccgcaa caataatatt agcaatgatc accttttgcc gcgcaagcaa
     7141 cggcacaaag gcaaacaaac tgcctttgtc ctctttgcgc ggttgatatt gcggttcagg
     7201 agcaataaag atagccaccc ccgaccactc cttggcaaac tcatcttttg aaagccaggt
     7261 catcgcgact gaagggtcag gatcaccaat taagatatga tccttcgttg ccttaaatac
     7321 aacataataa tgcagcaatt cgccgcgctt caaaacatgc accaagatcg gatatgaaac
     7381 atcatctaaa ttaaacaacg tcatatccgc cttaactgcc ttggtttcaa aatgaagttc
     7441 ctgggcagcc cgaacaatgc ctagtgctgt tgttccttcc tgatccgtct tggctaattg
     7501 ccgtaaatgc gcaagggaat agtcggactt atgaaacttc agtaacatat taagcgccgc
     7561 aacgccgcaa tcacgctcat ccacctgagg cgtgtaatag cgtttatagt atgttgcttg
     7621 acctagtttg aatttgtatt tgcccatcaa cagcctcctc ttattggatt tcagattgta
     7681 aaacatgcaa cgtcaacatt tcgcagaagc agacgcaaca agttggcccg gagcttatcc
     7741 ttttatcata gatattaagg ttaagcatct taactgccgt gaaaacaaat ctatggtaat
     7801 atgactctgt tgagagttaa cagcatctta aaatagagaa tttaatatta aataaaagtt
     7861 taagctcact ttttatttaa taaaggttta tttatccact acctaattca cacatctctt
     7921 ccaaggatat tatgtcttca cgcaattctc tttcttgcac ttcctaatgt cttcctcgaa
     7981 aaagttcgcc tatccagttt tttaaaccct taaatggttg gcttatgaca cgattagcac
     8041 ctccacgtac ttgtgaaagg ctgtaatccg atatgattgc ctctttctga ccactctttt
     8101 tgtcattcat ggtaagttcc tcctagacaa tttatttgat accaccagcc tagcatgtat
     8161 ggcacaattg ttgttcaaca aaaaattaac gtcgtgtttt ggccaattaa cgtcgtgtta
     8221 taacacaaat gcaagaaata acttggccta tcctcaagaa agtgggagtt tttgatatgg
     8281 ttagtctgcc gagtcatata tactttttta taaattggcc aatcttcttt tttggcgttg
     8341 gatttctttc gtatatcttc tttggcctca tccgtccgct gcacgttgct tcatggtcaa
     8401 ttattggaac atcactctct ttgttcctgt cgacttacgg agaaattggt ttttgtttaa
     8461 tatacgcttg gtatatatcc agaaccaatg caagttctga caagttttgg gtctttattt
     8521 ttatggaagt taaccttatc atcatcacga ttcaaacctg tatcataaga atttttgccg
     8581 cggcaggtac gaaacaactg actttaatta gtgtaggcac cacacttatt ctcacttcaa
     8641 cattagcagc gattgtaatc tcgctactag taaaaaagcg aagtcaactc gatcagctgc
     8701 gaacgctcat caaggagcaa aaccatctcc agaaatcaat tattatctat acaggtgcga
     8761 cctgtgtctc gctatattgt tttgaggcga tatctaatct agtcaacata ggcatcatgt
     8821 tagacttgct tattcttggt atctttacac tgtcagtcat catcaaccta tattcacttt
     8881 tcttgatttt gaagtcgttc agttactatg ttgaactcac ctggatcaag cgtgccgagg
     8941 cttctcaacg ggcgtactac accacactga gccaacagca aaaaaccacg aacaagcttc
     9001 tacacgacta caaaaatctg ttagcctcgc ttcaactatc tctgcagcaa tcctcttcaa
     9061 ccatctctcc ggatacccaa gccatccttt cgcgggccca ggcatcgcta aaccaggcag
     9121 aattaagcaa aagttcattc acagcaatta aaagtgatcc tttaaagagc ctgctttatt
     9181 taaagtgggc tgaatcaatg aaccacaata tcatcatgaa tgttcaaact aaaggaatca
     9241 ttcatcctct agaaagtggt cttggctttg ccattatcag ggcgcttggc atcttgatcg
     9301 acaatgcgct agaggaaact gtcagaatta aacatcatcg cttcgatgtc acgttaattg
     9361 ccttaaagca aggtctagaa gtcagcgtca tgaacgatgt cggtcctgac ttcaatctgg
     9421 cagatcttga aaagaaggac tttacgacta agggcgacgg acatggcaat ggcttgtcca
     9481 tcatcaatga gctcatgcaa caaaacaaaa atattcttat cagaaaatcg gttattagcc
     9541 aacagctgaa aatcacttta ttcataggag attcatgata tgatcactaa ccgtacgacc
     9601 ttgaaaatct tcatcttgga agacgatgct accttcctga ggttcatcga aaaaacgctc
     9661 agaaactaca ttatgattga agaattgcat gcggaaatta aaattgctac ccaatctgct
     9721 acggatctgt taaacgccat tgatctgcag caaattaatg acagcttctt tctgctggcc
     9781 attgatattc ccggatcctc tatcaatggt attgatattg ccaacattgt ccggaaacat
     9841 tcgctatatg cagacatcat gttcattacc agccacaccg aacaagcact tgccattcta
     9901 tcccagaaga ttctaccttt agacttagtg gataaaagcg tgcctgcaga agttgaaacg
     9961 cggctgcgta ccaatcttgt tcaagggata aagcgattac ggtcacgtca actcgaatct
    10021 ccacggctat tcagctacca gatcggagcc aatctctttt cacttccgct agacgacgtg
    10081 ctgtacattc aaaccgtgct cggtacacct agcacgctcg aattgcacgc taaacatgaa
    10141 accacgactt tcccagggaa cttaaaggaa gtttcaactc gatatccaac cttatttcga
    10201 tgccatcgaa gtttcctgct taaccccctt cacgttcaca aattgaacgc ctctggtcgg
    10261 tttgtttaca tggataatca ggataagctt gacgtcagca ttcgtaaagt ttcagcttta
    10321 cgtaaactca tggcagcggc taatcgttca catgctgagg ctaacaatct ggcggatgac
    10381 gcttaaaaaa acgcccgtca ccctcgcggc aagtgcaaaa aaggcccaga aattcttccg
    10441 ttttcgaagg aatatctggg cctttagaaa gcttgtcgat tgagctgact tttcgccgat
    10501 tctcgggcta ttggtcgctg attcaaagaa cagctgaaaa agcatattaa ggaatacaac
    10561 agccgctcat tcacttgcga tccaatcata gttgcctaat tgtttgtact caaagacagc
    10621 atcccaaaat gttttttctg actcactgaa agaaatactg tcagacaatt tgataaccgg
    10681 tgcggtgtta aagaagtatt ggagcttgtt gtggaatgca agaccatcgc acgttttcaa
    10741 cacttctaat tctcggtcaa caaacagtgc tgtttcagag tttttatgac acatactcaa
    10801 cttaatggct agcttctcca ttgcaacaat tatctcatct ttagatggca tttttctgct
    10861 cctacccgca gttgcgtgat tcttctgcct ttataaacaa acttttaaat atggtcattc
    10921 cttgttgttt cgttgtcgat catacgctct tgtcattgtg aacagttttc tcaaaaaatc
    10981 gtacgaattg gatagaattg caatgaggat aatcgcatac acttgccaaa tcgcatcatc
    11041 agaaatgatc cataatagta tgaacaaaca aagctggact atccacatag agagcggttg
    11101 tttaagtcgc ctatgatcaa atacagccat tttctcccat ataagcgaat tcacttccga
    11161 ttcctccgat aattgctcct gcgatagtac ccgcaggacc taagagagac ccaagagatg
    11221 caccggaaag aaatccaaca gctcctgccc ctgcagtacc atagccacat gttcctagac
    11281 gactaccacc tgcaattttt gctaaatcag cgttagccaa taattgtaca tttttcataa
    11341 ctattactcc tttacaagcc ttttagtaaa atcatttggt tttgatagat cataggtgtt
    11401 gtcagcaaaa atcgttaaac gtttttaacg accgccaacc tgtctttccg aatagcatta
    11461 ccacggcctc tcccagcctt gtttaaaacc gtcaatcagc tggtcggcat gattaaatgc
    11521 atctgtcgcc agaatgccta gaatcgttgc taccggaatc gcgaatggta agaagccacc
    11581 tgtaatctgg caaagttcgg aatcttttaa attggtcatg acgctcatcc tttcttttga
    11641 ctaatcccta tggcaagttt tcttttcgtt tgagctcatt gagaacatcg atgccaaggc
    11701 tcattgcggg tgttgcaaaa ccaccttgag cccagcttcg tgcaattgct cccagtccca
    11761 tgccgatgta agtccaaaaa ttatcagtac cgccaccact gatccgttcc aggcggctat
    11821 catccaacgt cacgaattgt tgcatggcgt ttcctccatt tcttcgactt gttcacagcc
    11881 gatatattta aacttttagg gtgctagctt ccctaaacac aatatacgat aggcttgagt
    11941 tcatctgatt aattaatttt aaaccgcgca ttttagaatc aagttagcca ctgtctcaaa
    12001 attttttgga caataaaaaa catcaagaac agatatcctg tatcattgaa gttcctacac
    12061 aaacaatgga agaggatatt gtcttgatgc agaaacagga tagcacacac cgccaaaaag
    12121 gtcagcactt aacatcactc gagcgcggaa aagtggccgg attccaccaa gctgggaagt
    12181 ccaatcgttg gattgctgct gaaattggcg tctgcccgca gaccattaat aatgaaatca
    12241 agcgaggtac agtagatcag gtcaagaaga gtaatggcaa gcgcgtctac catcgacaat
    12301 acctgccaga ggctgctcag gcacgttacg agactgcacg cttgagctgc catcgtcctg
    12361 acaagttcgc cagcgtacag gtcttcttag cctggtacgt acagcgagct aagcaggaca
    12421 aatggtcgcc ggatgcttca atcggctatg ccaagcgaca caagctgttt actcctgaag
    12481 agcttgtttg tgcctcgact ttgtaccagt acattgacga ccaacgccta gagattcgaa
    12541 atatcgacct gttggagaag actaagcgga agacctctca ccagcaccac accaaggcta
    12601 agcgcctggc tggccgcagt atcgaggaac ggcctaaggt cgttgaacga cgcaggcagt
    12661 tcggtcactg ggagatggat accattgtcg gtaaacgcaa tggcaaggag agcgtcatct
    12721 tgactctgat tgagcgcaag acccgttgcc aacttctccg cttgatcgaa ggacgagatg
    12781 cagactctgt gagctatgca ttgcgtggaa tcaagcgcga atggggagct tgcatcaaga
    12841 ccatcacagc cgacaacgga cccgagttca ccgccttaaa tactgctttt gctgggacgg
    12901 aaactgagat cttctacgcc catccttaca cgtcctgcga ccgtggcacc aacgaggcac
    12961 ataaccggat gatccgccag gacttcccta agggcatgtc cttagatgac attagcccta
    13021 gtcaagtgca ggccacgcaa gaccgctcga atcagttgcc tcgcaaacaa cagggctact
    13081 gcacacccca gcaaaacttt gaggccgaag ctcggcgcgt tcgccgcatg gcccagtagt
    13141 ctctctagcg ccacaacttc tatttgataa cggcctgttc tgggattgtc ctcaacgact
    13201 ggctaacttg ttcttgcaat ttacgatcgc gcattttaga atcaagttag ccactgtctc
    13261 aaaatttttt ggacaataaa aaacatcaag aacagatatc ctgtatcatt gaagttccta
    13321 cacaaacaat ggaagaggat attgtcttga tgcagaaaca ggatagcaca caccgccaaa
    13381 aaggtcagca cttaacatca ctcgagcgcg gaaaagtggc cggattccgc caagctggga
    13441 agtccaatcg ttggattgct gctgaaattg gcgtctgccc gcagaccatt aataatgaaa
    13501 tcaagcgagg tacagtagat caggtcaaga agagtaatgg caagcgcgtc taccatcgac
    13561 aatacctgcc agaggctgct caggcacgtt acgagactgc acgcttgagc tgtcatcgtc
    13621 ctgacaagtt cgccagcgta caggtcttct tagcctggta cgtacagcga gctaagcagg
    13681 acaaatggtc gccggatgct tcaatcggct atgccaagcg acacaagctg tttactcctg
    13741 aagagcttgt ttgtgcctcg actttgtacc agtacattga cgaccaacgc ctagagattc
    13801 gaaatatcga cctgttggag aagactaagc ggaagacctc tcaccagcac cacaccaagg
    13861 ctaagcgcct ggctggccgc agtatcgagg aacggcctaa ggtcgttgaa cgacgcaggc
    13921 agttcggtca ctgggagatg gataccattg tcggtaaacg caatggcaag gagagcgtca
    13981 tcttgactct gattgagcgc aagacccgtt gccaacttct ccgcttgatc gaaggacgag
    14041 atgcagactc tgtgagctat gcattgcgtg gaatcaagcg cgaatgggga gcttgcatca
    14101 agaccatcac agccgacaac ggacccgagt tcaccgcctt aaatactgct tttgctggga
    14161 cggaaactga gatcttctac gcccatcctt acacgtcctg cgaccgtggc accaacgagg
    14221 cacataaccg gatgatccgc caggacttcc ctaagggcat gtccctagat gacattagcc
    14281 ctagtcaagt gcaggccacg caagaccgct tgaatcagtt gcctcgcaaa caacagggct
    14341 actgcacacc ccagcaaaac tttgaggccg aagctcggcg cgttcgccgc atggcccagt
    14401 agtctctcta gcgccacaac ttctatttga taacggcctg ttctgggatt gtcctcaacg
    14461 actggctaac ttgttcttgc aatttacgga tcccaacgaa ccaaaaagtc cgacaagatt
    14521 ttgacattta gtcaaatctt gtcggacttt ttaacgagcc acataaaatt aaaatgcttt
    14581 atttgcgtgc cttaacacgc tagctgatgt ttacggcaaa tcattgcctg ccgcaaagta
    14641 aatgttgtac cactcttgcc gcgtcagcgt gatgtccgcg ccggctgcac tttccttaat
    14701 atgctcaggg ttcatggagc cgaggataac ctggacaccg actggatggc gcaagagcca
    14761 agcaacggcg atggcatttt tattagtgtg atagtgctcg gcgacttttt gcagctcatc
    14821 gttcagatcc ttgaacttcg gactgtcgat gaaggtaccc tcaaacatcc cgtattggaa
    14881 cggtgaccat gcctgcaagg tcatttgttt gcgctggaga taaggcaaca gactgccatc
    14941 atggtcgatg gaccggtcgt cttccatgtt cgtgtgcatg cctgcattga ccataccagt
    15001 atgggcgacc gagaattgca cttgatcgat taatagatgc tggtgaatgc cgctttgtag
    15061 caaggcaatt tgctcgggat taaagtttga aacgccgaaa tgacgaactt tgccgctttg
    15121 ctgcaactcg tcaaatgccg ccgcgacatc gtccacttcc attaatggat ccggccggtg
    15181 caataacact gaatcgagat agtcgatttg caggcgctcc aagatcttat caactgcgcc
    15241 cagcaagtgt tcctttgaaa agtcatagcg ccgtccaaaa acaagactgc cgtgtgaacg
    15301 atctgggtca accacgatac cgatcttcga ctgaatatag agttgatcgc ggttaacacc
    15361 ggattgcttc aaggcttcac cgaaaacttc ttccgacttg ccttgaccat aaatatccgc
    15421 ggaatcaata aagttaatgc cgtcattata cgcactgtct aaaacgatcg cagctttttc
    15481 cggcgaaagt acattcatgc gcatgatgcc cagtgccacg cttgaagcct gccagttaga
    15541 accgcctaat cgcacttgtt tcat
//
