LOCUS       NC_002967.9            11099 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_002967.9 Treponema denticola ATCC 35405, complete sequence.
ACCESSION   NC_002967
VERSION     NC_002967.9
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:05:53
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 749266
            Orig. end    :: 760365
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1344
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_676"
                     /sec_met_domain="Peptidase_S41 (E-value: 1.4e-24, bitscore:
                     83.8, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNNLLFIYDIIKIKFRRMIKKINMKKLIISLIIFIFVSVFVVIAL
                     NVSKKNDIISGFISAEKMKADYEYFWDFIYKGYPFTEVCERKGADLEQIKQSGYRYLTD
                     PMMQYGYYFFYKDLCRKITGNRYIGHLYPSDYFDYYFNYEKIFKNGAPQTSLIKKRALI
                     DNFYFHIYQVEVLSDKNIGSFNNRNSSLIGTRKYSKPFIQIIETDHIAYIEIKSFLTTK
                     AEEKQEYLKALEDFFIETANYKHIIIDIQNNGGGHPENYEAIISPNINKEINIISYGLY
                     NENKYTNTYLDMFFKNYKSEKINRHEVPYIENCSTVKNDKAYRLEEIIQARPINGYKPC
                     EDKKFWLLVDSGVYSEADRFTYICKKIGFATVVGTNTGGSGTNGKSPMYIVLPNSGLLI
                     KFDFMYGLTEDGYCTDETGTAPDIYNLPGKSALGTCLEEIRKLREKTN"
     protocluster    1..11099
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[753601:755755](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4336..6489
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..11099
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11099
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     628..1269
                     /aSDomain="Peptidase_S41"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03572.20"
                     /description="Peptidase family S41"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_676_0013"
                     /evalue="1.40E-23"
                     /label="ctg1_676"
                     /locus_tag="ctg1_676"
                     /protein_end="423"
                     /protein_start="209"
                     /score="83.4"
                     /tool="antismash"
                     /translation="IAYIEIKSFLTTKAEEKQEYLKALEDFFIETANYKHIIIDIQNNG
                     GGHPENYEAIISPNINKEINIISYGLYNENKYTNTYLDMFFKNYKSEKINRHEVPYIEN
                     CSTVKNDKAYRLEEIIQARPINGYKPCEDKKFWLLVDSGVYSEADRFTYICKKIGFATV
                     VGTNTGGSGTNGKSPMYIVLPNSGLLIKFDFMYGLTEDGYCTDETGTAPDI"
     CDS             1702..2538
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_677"
                     /sec_met_domain="Abi (E-value: 3.6e-24, bitscore: 82.3,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYNKKKVLAVFYWFISIIIEAFIAFFILDLIYVYVFMYKEEYWY
                     IILAIGYTELGIAIITFKRFKENKNLLQFKPFKFSTVIKIYFIGIIITTLIAWIFRGFG
                     NFKNMIESSVIYFLNRFTGKESFTVRTIFNTNFIYKPLIIYEFVAALIIAPIYEELIFR
                     GVIYDDTKKLFNAKIAALVSSILFGLIHLYGGYAQVIGTIVSGLLSAYCYEKTKSLYAC
                     IFLHSLHNFIAVVMRRLLNWQTYVILILIFTPACIIMLIAEGIRYFGRRKALIIKE"
     PFAM_domain     2128..2397
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_677_0014"
                     /evalue="2.40E-23"
                     /label="ctg1_677"
                     /locus_tag="ctg1_677"
                     /protein_end="232"
                     /protein_start="142"
                     /score="82.4"
                     /tool="antismash"
                     /translation="IIYEFVAALIIAPIYEELIFRGVIYDDTKKLFNAKIAALVSSILF
                     GLIHLYGGYAQVIGTIVSGLLSAYCYEKTKSLYACIFLHSLHNFI"
     CDS             2653..3174
                     /locus_tag="ctg1_678"
                     /transl_table=11
                     /translation="LLFAFDFAPSWDFGHINIAGSFSKDSQILYGSGTLSDINLSDADT
                     GVAFSFSPLEIESNQQLGKTNLFFINAEFSYNTFNNLYKIFRLAVFARINWLTESNIYK
                     YRFMSGLEFSIMAEMSPFCDWKFPLIFKVFSAKTGFRLDYPAKPSFFCSAGITLSLPLY
                     GLSQSANKNS"
     CDS             3326..3610
                     /locus_tag="ctg1_679"
                     /transl_table=11
                     /translation="MKDLLNKGFQPVSETEMVMVEGGCSHPFCFTDCTAAGTDSSNDNS
                     LLELLKNFKIKRDDVTIDWEGVHFDFSNFDLDIGGIGGGRAGIKVTIPL"
     CDS             3644..4039
                     /locus_tag="ctg1_680"
                     /transl_table=11
                     /translation="MKNKFLIMLLCVFIFSCSTMNSKHAAKNKLPIYVLSGKVRIELIC
                     QHSIYHHQNDSIIKIHRRGVNNDSLFEKRIMFFTAGEMFDQSLVFYDSIIAKVVAEEQP
                     AEIMCSGKYYKITPDNKSGIVFSFYKN"
     CDS             4089..4292
                     /locus_tag="ctg1_681"
                     /transl_table=11
                     /translation="MKKYFLYLKKGLIWSMLTVALIPFIHYLFVNSWYDWSWFALAIPI
                     FILLGGPLYVAAVEKINTAKKH"
     CDS             4336..6489
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 293; E-value: 7.7e-89)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_682"
                     /sec_met_domain="TIGR01193 (E-value: 4.5e-185, bitscore:
                     614.3, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.9e-39, bitscore:
                     130.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLIRQFDGTDCGAACLAMVASHYKAKYSVTSIREIAETDTHGTN
                     LAGLVKAGEAMGFSVQVLKGDKEALSQDLPLPFIVHIKKCEEKREFFHFVVVKKIKNKK
                     LTIYDPAGEKKKIDIEEFAKTWTGYTVFLSPSAEFKIQDNTKGFFERFVPLLKPYIHEI
                     IQVIIASFLLTFLGIISSLYFRYIIDDVVYSKAFTSLTSLSIGIIVLTLFSSGLSAVRS
                     HIILFFSLKMDYHLIFSYFKHVFSLPIKFFDTRKTGEILSRINDAQKVRSALSGTAVSV
                     VIDSCMVIIAGVVLYFKSPFLFWIGLITVPLSSIIIWLFSKKFAKAYRELMGQLSEVQS
                     YLVEAVSGAASLKALNAEDSVYDEYEKREVKAVKINYRLGVLSNIQSFLNSILTGWSSN
                     IIFWVGTYLILKDQFTVGQLISFNALLGFFTGPLQRLLTLQPSLQEAFVAGSRLGEIFD
                     LKKEIADEGYWIKPEKILGNIEIKDLIFRYGTRKPVLNKISLNINAGESIGFVGASGSG
                     KTSLIKLLLKFYSPESGSIKIDGHNIEDIDTKTLRAKIGYVPQDIFLFSGTIAENISIH
                     DDNASIEDIIRVSMETGVHSFVENLPERYNTVLAERGISLSGGERQRIALARALISDPD
                     LLIFDEATSNLDTISEKQIHGIIENIKTKKITTLMIAHRLTTVKNCDKIFVMQNGVIAE
                     EGNHSSLLEKKGLYYKLWNGDIL"
     PFAM_domain     4342..4746
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_682_0015"
                     /evalue="3.70E-38"
                     /label="ctg1_682"
                     /locus_tag="ctg1_682"
                     /protein_end="137"
                     /protein_start="2"
                     /score="130.4"
                     /tool="antismash"
                     /translation="LIRQFDGTDCGAACLAMVASHYKAKYSVTSIREIAETDTHGTNLA
                     GLVKAGEAMGFSVQVLKGDKEALSQDLPLPFIVHIKKCEEKREFFHFVVVKKIKNKKLT
                     IYDPAGEKKKIDIEEFAKTWTGYTVFLSPSA"
     aSDomain        4351..6474
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_682_0003"
                     /evalue="7.90E-185"
                     /identifier="TIGR01193"
                     /label="ctg1_682"
                     /locus_tag="ctg1_682"
                     /protein_end="713"
                     /protein_start="5"
                     /score="614.3"
                     /tool="antismash"
                     /translation="QFDGTDCGAACLAMVASHYKAKYSVTSIREIAETDTHGTNLAGLV
                     KAGEAMGFSVQVLKGDKEALSQDLPLPFIVHIKKCEEKREFFHFVVVKKIKNKKLTIYD
                     PAGEKKKIDIEEFAKTWTGYTVFLSPSAEFKIQDNTKGFFERFVPLLKPYIHEIIQVII
                     ASFLLTFLGIISSLYFRYIIDDVVYSKAFTSLTSLSIGIIVLTLFSSGLSAVRSHIILF
                     FSLKMDYHLIFSYFKHVFSLPIKFFDTRKTGEILSRINDAQKVRSALSGTAVSVVIDSC
                     MVIIAGVVLYFKSPFLFWIGLITVPLSSIIIWLFSKKFAKAYRELMGQLSEVQSYLVEA
                     VSGAASLKALNAEDSVYDEYEKREVKAVKINYRLGVLSNIQSFLNSILTGWSSNIIFWV
                     GTYLILKDQFTVGQLISFNALLGFFTGPLQRLLTLQPSLQEAFVAGSRLGEIFDLKKEI
                     ADEGYWIKPEKILGNIEIKDLIFRYGTRKPVLNKISLNINAGESIGFVGASGSGKTSLI
                     KLLLKFYSPESGSIKIDGHNIEDIDTKTLRAKIGYVPQDIFLFSGTIAENISIHDDNAS
                     IEDIIRVSMETGVHSFVENLPERYNTVLAERGISLSGGERQRIALARALISDPDLLIFD
                     EATSNLDTISEKQIHGIIENIKTKKITTLMIAHRLTTVKNCDKIFVMQNGVIAEEGNHS
                     SLLEKKGLYYKLWN"
     PFAM_domain     4828..5634
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_682_0016"
                     /evalue="6.40E-46"
                     /label="ctg1_682"
                     /locus_tag="ctg1_682"
                     /protein_end="433"
                     /protein_start="164"
                     /score="157.3"
                     /tool="antismash"
                     /translation="QVIIASFLLTFLGIISSLYFRYIIDDVVYSKAFTSLTSLSIGIIV
                     LTLFSSGLSAVRSHIILFFSLKMDYHLIFSYFKHVFSLPIKFFDTRKTGEILSRINDAQ
                     KVRSALSGTAVSVVIDSCMVIIAGVVLYFKSPFLFWIGLITVPLSSIIIWLFSKKFAKA
                     YRELMGQLSEVQSYLVEAVSGAASLKALNAEDSVYDEYEKREVKAVKINYRLGVLSNIQ
                     SFLNSILTGWSSNIIFWVGTYLILKDQFTVGQLISFNALLGFFTGPL"
     PFAM_domain     5818..6267
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_682_0017"
                     /evalue="1.30E-35"
                     /label="ctg1_682"
                     /locus_tag="ctg1_682"
                     /protein_end="644"
                     /protein_start="494"
                     /score="123.0"
                     /tool="antismash"
                     /translation="LNKISLNINAGESIGFVGASGSGKTSLIKLLLKFYSPESGSIKID
                     GHNIEDIDTKTLRAKIGYVPQDIFLFSGTIAENISIHDDNASIEDIIRVSMETGVHSFV
                     ENLPERYNTVLAERGISLSGGERQRIALARALISDPDLLIFDEATS"
     CDS             6486..7628
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 70.2; E-value:
                     2.5e-21)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_683"
                     /transl_table=11
                     /translation="MKIKDLETIKNRILFFEYRFPVVYTCFIYIILFIFIITLLWICFA
                     EMDQTVKASGILRLKTNTSIGKAAYSGTVKSKKFKSGSRIKKGDILLILETADIEEDKT
                     NTENEIHRLNKEINNLLLYEKAVHSDKNNVPLEHAIAKARAEIYFAKKEKLRIFYEEAK
                     EEYAHEKELPSSMKTKKSLSSLFDKFKIAELDYKTFSAQEIINIESEKNLLTQKLESAK
                     KTLTRLNKEISESKIISPLNGTVEELIRINEGDYIFSGTEILRIIPDMIEELKAELIIS
                     DKDIAELKIGMEVNLKFTALPPSEYGVLKGVITNISNDSFNNQNTSSFFLVDADILSFS
                     LKNNEQKEVKLKPGMSTEAHIIIKHKTIIKFILEKLDFIK"
     PFAM_domain     7194..7547
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_683_0018"
                     /evalue="1.20E-14"
                     /label="ctg1_683"
                     /locus_tag="ctg1_683"
                     /protein_end="354"
                     /protein_start="236"
                     /score="55.0"
                     /tool="antismash"
                     /translation="IISPLNGTVEELIRINEGDYIFSGTEILRIIPDMIEELKAELIIS
                     DKDIAELKIGMEVNLKFTALPPSEYGVLKGVITNISNDSFNNQNTSSFFLVDADILSFS
                     LKNNEQKEVKLKPG"
     CDS             7625..9010
                     /locus_tag="ctg1_684"
                     /transl_table=11
                     /translation="MKRIGLILIFFIFPCLIFTESRDWDVFFNERLSYSLSASLNDIEF
                     KKIELLEYKEKTKWIPSLSFDFPKLFAWKNIPVELSGANSLIKTKYIDVFNGKYSLVLN
                     QALPSAGNILFSFNFNYEYLLQSKEFKQIPSFTIQFSQPITKYSFGFVNEAKKISFLKK
                     SVKEKRFALYADFIKIFLKSALNIEVLNAESVYLKNKYLYAAEQYSTAEIEFKKERLKL
                     DALLQIKQKMIEAKQEYGLNLNSLNRLKEEFVLNYNYEYSLINEEDMSSLLEFLENLFL
                     DSYIFDIQNTEYEIFLLNAEKEQAYIKNAPRFNIGFSHAPNTLKTRFSSYTASWQNLKQ
                     TEWLPELFISFSWTPDYTFTQKKEIDLIDLKISYAKNKLKTLKEKKEIKNKAKTLRIKN
                     LKEDLHILSENLNLYLELNEEYKKLYKDGVITNLSLLEYTVNPSRQRLLKLKKLKDLIF
                     EIF"
     CDS             9140..9328
                     /locus_tag="ctg1_685"
                     /transl_table=11
                     /translation="MKDLLNNGFQPVSETEMVMVEGGGGASDMVIDGDNPGAQRPTPPP
                     PPSNGGGCGDVNWLEMR"
     CDS             9393..10658
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_686"
                     /sec_met_domain="Peptidase_S41 (E-value: 8e-24, bitscore:
                     81.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQFLFILIFIFIIFFACSDYTNGDEVRFISYKKMLSDYEYFWD
                     FIYKGYPFSEVCERNGADLKKMKIKNYESLSGLASENAYLAFYDRLCRQITIGKSIGHL
                     YAVDKYDYKYVFKTSMIGGPFITKILLIDGFYSKLIGGRSSTEIEKNIFYCDFFNDEFP
                     CYSCDIYTGFLKRIIEPGKIAYVKLDSFLIVSREIELQYLRDLKDFFIETADYKHIIID
                     IQNNGGGYIENYEAIISPNIKENLTIVSYGLYNENKYTNPYLEMFFKGYRDIKKIEKHE
                     VPNIENCGTVKNDKAYKLEDMIEPSYILDYKPCEDKKFWLLVSGDVYSAADRFTYVCKK
                     TGFATVIGTNTKGAGNNGLWPMYIVLPNSGLLIKFDFIYGLTDDGYCTDEFGTAPDIYN
                     LPGKDALETCLEEIRKLGEKTN"
     PFAM_domain     9936..10583
                     /aSDomain="Peptidase_S41"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03572.20"
                     /description="Peptidase family S41"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_686_0019"
                     /evalue="8.20E-23"
                     /label="ctg1_686"
                     /locus_tag="ctg1_686"
                     /protein_end="397"
                     /protein_start="181"
                     /score="80.9"
                     /tool="antismash"
                     /translation="KIAYVKLDSFLIVSREIELQYLRDLKDFFIETADYKHIIIDIQNN
                     GGGYIENYEAIISPNIKENLTIVSYGLYNENKYTNPYLEMFFKGYRDIKKIEKHEVPNI
                     ENCGTVKNDKAYKLEDMIEPSYILDYKPCEDKKFWLLVSGDVYSAADRFTYVCKKTGFA
                     TVIGTNTKGAGNNGLWPMYIVLPNSGLLIKFDFIYGLTDDGYCTDEFGTAPDI"
     CDS             10914..11099
                     /locus_tag="ctg1_687"
                     /transl_table=11
                     /translation="MLRLNIVSEREMLMVEGGAGDNGPQKGKDPSCPLPDEGGGGKIIR
                     PPRPGSGKKDPESPSP"
ORIGIN
        1 ttgaataatt tattgttcat ctatgatata ataaaaataa aatttcgtcg aatgattaaa
       61 aaaattaata tgaaaaaatt aataatcagc cttataatat ttatttttgt ttccgtgttt
      121 gttgtaatag ctcttaatgt atcgaaaaaa aatgatataa tatcaggttt tatttctgcc
      181 gaaaaaatga aagccgacta tgaatatttt tgggatttta tttataaggg ctaccctttt
      241 actgaagtat gtgaacgaaa aggagcggat ttagaacaaa taaaacagtc cggatataga
      301 tatttaacgg atcccatgat gcagtatggg tattattttt tttataaaga cttatgcaga
      361 aaaattacgg gaaatagata tataggtcat ctttatcctt ccgattattt tgattattat
      421 tttaattatg aaaagatatt taaaaatggt gcccctcaga cttcattaat taagaagcgg
      481 gctttgatag ataactttta ttttcatata tatcaagtag aggttcttag tgataaaaat
      541 atcggtagtt ttaataatag aaattcttca ttaataggaa ctcgtaaata ttcaaagccg
      601 tttatacaga ttattgagac cgatcatatt gcatatatag aaatcaaatc ttttcttaca
      661 acgaaagcag aagaaaaaca agagtatcta aaagccttgg aagatttttt tattgagact
      721 gcaaattata aacacataat aatagatata caaaataacg gaggcggaca tcctgaaaat
      781 tacgaagcaa taatatctcc caatataaat aaagagataa atataatttc ttacggactt
      841 tataacgaaa ataaatatac gaatacttat ttggatatgt tttttaaaaa ttataaatca
      901 gaaaaaataa atcggcatga agttccttat atagaaaatt gcagtactgt aaaaaacgat
      961 aaggcctata gattggaaga gataattcaa gctcgtccta ttaacggata caagccttgt
     1021 gaagataaaa aattttggct tcttgtagat agcggcgtat attctgaagc cgatcgtttt
     1081 acttatatct gtaaaaaaat cggctttgca acagttgtcg ggactaatac gggaggttcc
     1141 ggaacaaacg gtaaatcgcc tatgtacatc gttcttccca acagcggctt actgataaag
     1201 tttgatttta tgtacggcct aaccgaagac ggatactgta ctgatgaaac aggtactgct
     1261 cctgatattt ataatcttcc cggcaaaagt gcccttggaa cctgtttaga agagataaga
     1321 aaattaaggg aaaagacaaa ttaggggaaa agacaaactt ttgatggagc aaaagttttt
     1381 cttctcccct ataacccctc atcttttcaa aacgccattt aagaggggaa cattttttag
     1441 ctcccctctt aaaaatctcc cctgatttag aggtatggat tgtcattaag acaaacctac
     1501 ggtttttctt aataatcttt tccctttgcg aagttgagcg ttagctcaat gcttggcgtt
     1561 cgctacggtt attaaaaata aataaaattg taaatttatg taaagaaaat actataaatc
     1621 ttccttgaca aataagcagg gctgctctat acttataagt gaagccgtaa cagtgtcatc
     1681 acttattagg agtactgttt tatgccatat aacaaaaaga aggttttagc tgttttttat
     1741 tggtttatat cgattataat tgaagccttt attgcatttt ttattcttga tcttatatat
     1801 gtatatgttt ttatgtataa agaagaatac tggtatataa ttctggctat tgggtatacg
     1861 gaactgggca ttgcaatcat aacatttaaa cggtttaaag aaaacaaaaa tcttttacaa
     1921 tttaaacctt ttaagttttc tacggttata aagatatact ttattggtat cattataact
     1981 acacttatag catggatttt tcgtggtttc ggtaatttta aaaatatgat agaaagttcg
     2041 gttatttatt ttttaaacag atttacggga aaagaaagct ttaccgtccg taccatattt
     2101 aatactaatt ttatatacaa gccattaatt atttatgaat ttgtagcggc tcttatcata
     2161 gcaccgatat atgaagaact tatatttagg ggagtaatct atgatgatac aaaaaaatta
     2221 tttaatgcaa aaattgccgc tcttgtttct tcaatactat tcggcttaat acatttatat
     2281 ggaggctatg cccaagtgat tggaaccatt gtaagcggtt tactatcagc ttattgttat
     2341 gaaaaaacaa aatcgcttta tgcatgtatc tttctccatt ctttacacaa ttttatagcc
     2401 gttgttatgc gtagattatt aaattggcaa acatatgtta tacttatcct tatttttacg
     2461 cctgcctgta taattatgct tattgccgaa gggattaggt atttcggcag aagaaaggca
     2521 ctcattataa aggaatgatt ttatgccata taacaaaaat aggaaaataa tgaaagttat
     2581 tcaatctaaa aaaattatca caaaaaaaat attagctatg agtgtattga tttatatttt
     2641 agctgtgctg atttgctttt tgctttcgat tttgctccct cgtgggattt tggacacatc
     2701 aacattgcag gaagtttttc aaaagattca caaattctat atggttctgg aactttatcc
     2761 gatataaatc tttcagatgc tgacacaggg gtagcatttt ctttctcgcc tttagaaata
     2821 gaatcaaatc aacaattagg gaaaaccaat ctgtttttta taaatgctga attttcatat
     2881 aacacattta ataatctata taaaatattt cgcttagcag tgtttgccag gataaattgg
     2941 cttacagaat ctaatattta taaatataga tttatgtccg gtcttgaatt ttcaataatg
     3001 gcagagatgt ctccattttg cgattggaaa tttccactta tttttaaggt tttttcagct
     3061 aagacaggtt tcagattaga ctatccggct aaaccctctt ttttttgtag tgcaggcata
     3121 acactttcac tccccttgta tggcttaagt caaagtgcta ataaaaattc ctaatatagg
     3181 agaaaattaa aatgaaaaaa ttacaaattt ctgtaaaaaa gcacttgaca tattgcaaaa
     3241 gtatggtaca cttaaagtaa ggtcttttga aaagcctaaa aatatttaag tttaggtgta
     3301 ggagcctaaa caaaggagtt gttttatgaa agatttattg aacaaagggt ttcagcctgt
     3361 gtctgaaaca gagatggtaa tggttgaggg tggttgttcc catccttttt gttttactga
     3421 ttgtacagcc gctggtacag acagttcgaa tgataattca ttacttgaac tgttaaagaa
     3481 ttttaagatt aaaagggatg atgtaacaat agattgggaa ggggttcatt ttgatttttc
     3541 aaactttgat ttagatattg gtggaattgg aggtggtcga gccggaataa aagttacaat
     3601 accgctttaa atattttgat ttaattcgac aatgggagtt taaatgaaaa ataaatttct
     3661 aataatgttg ttgtgtgtat ttatattttc ttgctcaaca atgaatagta agcatgcagc
     3721 taaaaataaa ctaccgattt atgtattatc aggaaaagtg cggatagaac ttatatgtca
     3781 acattctata tatcatcatc aaaatgattc tataattaaa attcataggc gaggtgtaaa
     3841 taatgattca ctatttgaaa aaagaataat gttttttacg gcgggtgaga tgtttgatca
     3901 atcattggta ttttatgact ctattatagc taaagttgtt gcagaggagc aacctgctga
     3961 aataatgtgt agcggaaaat attataaaat tactcctgat aacaaatctg ggatagtttt
     4021 ttctttttat aaaaattaag cttaacataa gatgcaaata gtgttataat gtattttgag
     4081 gagagatcat gaaaaaatat tttttatatc taaaaaaagg attaatatgg tcgatgctaa
     4141 ctgttgccct aattccgttc atacattatt tattcgtgaa ttcttggtat gactggagtt
     4201 ggtttgctct tgcaattccc atatttatac tactcggcgg tccgttgtat gtagctgcag
     4261 ttgaaaagat aaatactgca aaaaaacact aaatatggat tcggttaaaa ctaccataat
     4321 gtttttatat tagatatgcg tttaattaga caatttgacg ggacggattg cggggcggct
     4381 tgtcttgcta tggttgcatc ccattacaaa gcaaaatact ctgtaacatc gatccgtgaa
     4441 attgccgaaa ccgatacgca cggtacaaat cttgcgggtc ttgtaaaagc tggcgaagct
     4501 atgggctttt cggtgcaagt tttaaaaggc gataaagaag ccctaagcca agacctgccg
     4561 cttcccttta ttgtccatat aaaaaaatgt gaagaaaaaa gagaattttt tcattttgtt
     4621 gttgtcaaaa aaataaaaaa caaaaaactt acaatatacg atccagcagg ggaaaagaaa
     4681 aaaattgata ttgaagagtt tgcaaaaaca tggacggggt atactgtttt tcttagtccc
     4741 tcagcagagt ttaaaataca ggataatacc aaaggatttt ttgaacgctt tgttccgctt
     4801 ttaaaaccct atattcacga aataattcaa gttataatag catctttttt attgaccttt
     4861 ttgggtatta taagttccct ttattttaga tacataatag atgatgtagt ttactcaaaa
     4921 gcttttacat ctcttacaag tctttctata ggaataattg ttttaactct tttttcgtca
     4981 gggctttctg cggtgcgttc tcatattatt ttgttttttt cattaaagat ggattatcat
     5041 cttatctttt catattttaa gcatgtgttt tctctaccta taaaattttt tgatacaaga
     5101 aaaacgggcg aaattctttc ccgcataaat gatgctcaaa aggtccgttc cgccctttcc
     5161 ggaacggcgg tttcggttgt cattgattct tgtatggtaa ttattgcagg cgtggtactt
     5221 tattttaaat ctccctttct tttttggata ggtcttatta ccgtgccttt atcttccatt
     5281 ataatatggc ttttttcaaa aaaatttgca aaggcctacc gtgagcttat gggacaatta
     5341 tcagaagtac agtcatactt ggttgaagcc gtttcagggg ctgcctcatt aaaggccctt
     5401 aatgcagaag attcagttta tgatgaatat gaaaaaagag aggtgaaagc cgtaaaaata
     5461 aactataggc ttggagtttt aagcaatatt cagtcttttt taaattctat tttgacgggt
     5521 tggagttcca acattatttt ttgggtgggg acttatttaa ttttaaaaga tcaatttact
     5581 gtaggacagc ttatctcatt caatgctctt ttgggctttt ttacaggtcc tttacagagg
     5641 cttttgacgc tgcagcctag cttgcaggaa gccttcgttg caggaagccg tttgggagag
     5701 attttcgatt taaaaaagga aatagcagat gaagggtatt ggataaaacc tgaaaaaatt
     5761 ttaggcaata tcgaaatcaa agacctgatt tttagatatg gaacacgtaa gcctgtttta
     5821 aataagatat ctttaaatat aaatgcagga gaaagtatag gctttgtcgg agcatcaggc
     5881 tcgggaaaaa caagccttat taaactgctt ttaaaatttt attcgcctga atcaggctca
     5941 ataaaaattg atggacataa tattgaagat atagatacaa agactctgcg tgcaaaaata
     6001 ggttatgtgc ctcaagacat ctttttattt tccggaacta ttgcagaaaa tatttctatt
     6061 catgatgaca atgcttctat tgaagatatt ataagggtct ctatggaaac gggagtacac
     6121 tcttttgtcg aaaacctgcc tgaaagatat aatacggtcc ttgcagaaag aggaataagc
     6181 ctttctggag gagaaagaca gcgtatagcc cttgcccgtg cccttatatc ggaccctgac
     6241 cttttaatct ttgatgaagc tacaagtaat cttgatacaa tatccgaaaa acaaattcac
     6301 ggtataatcg aaaatataaa aacaaaaaaa ataacaactc ttatgattgc acataggctt
     6361 acaaccgtaa aaaattgcga taaaattttt gtaatgcaaa acggcgtaat tgccgaagaa
     6421 ggaaatcact catctctttt agaaaaaaaa ggcttatact ataagttatg gaatggagat
     6481 atcctatgaa aataaaggat ttggaaacga ttaaaaatag aatccttttt tttgagtata
     6541 gattcccggt ggtctatacc tgctttatct atataatttt attcatcttt ataattactc
     6601 ttttatggat atgttttgca gaaatggatc agacggtaaa agcatccgga atcctaagat
     6661 taaaaacaaa tacttcaata ggtaaggctg cttattcagg taccgtaaaa tcaaagaaat
     6721 ttaaatccgg ttctagaata aagaaagggg atattctttt gattttagaa acagccgata
     6781 ttgaagaaga taagactaat accgaaaacg aaatacatcg gttaaataaa gagattaata
     6841 atcttctttt atacgaaaag gctgttcatt cggataaaaa taatgttcct ttggaacacg
     6901 ccatagctaa ggccagagcc gaaatatatt ttgcaaaaaa agaaaagtta agaatctttt
     6961 atgaagaagc aaaagaagaa tatgctcatg aaaaagaatt gccttcttcg atgaaaacaa
     7021 aaaaatcgtt aagttcactt tttgataaat ttaaaattgc agaattggat tataaaactt
     7081 ttagtgctca agaaataata aacatagaaa gtgaaaaaaa tcttcttaca caaaaacttg
     7141 agtctgctaa aaaaacttta acccgcctta ataaagaaat atccgaaagt aaaataatat
     7201 ctcctcttaa cggtacggta gaagaattaa ttagaataaa tgaaggagat tatatatttt
     7261 caggtacgga aatactccgt atcattccgg atatgataga agaattaaaa gctgagttga
     7321 taatatccga taaggatata gccgaattaa aaatcggtat ggaagtaaat ttaaaattta
     7381 cggcacttcc gccttctgaa tacggtgttt taaagggggt aattacaaat atttccaatg
     7441 atagctttaa taatcaaaat acttcctcat tttttttagt agatgccgat atcctttctt
     7501 tttctttaaa aaataatgag caaaaggaag ttaagttaaa gcccggaatg agtaccgaag
     7561 cccatattat aataaaacat aaaacaatta taaaatttat tttagaaaaa ctggatttta
     7621 ttaaatgaaa cgtattggtt taatattaat tttttttatt ttcccgtgtt taatttttac
     7681 tgagagccgt gattgggatg ttttttttaa cgagcggctt tcatattctt tgtctgcttc
     7741 cttaaatgat atagaattta aaaagataga gcttttagaa tataaagaaa aaacaaaatg
     7801 gataccctca ctttcttttg attttccaaa gctatttgcg tggaaaaata ttcctgtaga
     7861 gcttagtggt gcgaattctt taattaagac aaaatatatt gatgttttta acggtaagta
     7921 ttctttagtg ctaaatcaag ctttaccctc agccggaaat attttatttt catttaattt
     7981 taattatgaa tatctattac aaagtaagga atttaaacaa attccatctt ttacaattca
     8041 atttagtcaa cccataacta aatatagttt cggttttgta aatgaagcaa aaaaaataag
     8101 ttttttaaaa aaatcggtta aagaaaaaag atttgcactc tacgcagatt ttattaaaat
     8161 atttttaaaa tcggctttaa atattgaagt tttaaatgcc gaatcggtat atttaaaaaa
     8221 caaatatctt tatgcagctg aacagtattc tacagccgaa atagaattta aaaaagaaag
     8281 attaaaacta gacgccttat tacagataaa acaaaaaatg attgaggcaa agcaagaata
     8341 tggcttaaat ctgaattctt taaatagatt aaaagaagag tttgttttaa attataatta
     8401 cgaatattct ttaataaacg aagaagatat gtcttctctt cttgagtttt tagagaatct
     8461 ttttttagac tcatatattt ttgatataca aaatactgaa tatgaaatat ttttactaaa
     8521 tgcagaaaaa gaacaagctt acattaaaaa tgcccctcgt tttaatatag gtttttctca
     8581 tgcccctaat acattaaaaa ctagattttc ttcttacact gcatcatggc aaaatcttaa
     8641 acaaaccgaa tggctgcctg agttatttat atctttttct tggactcccg actatacttt
     8701 tacacaaaaa aaagaaatag atttaatcga tttaaaaata tcttatgcaa aaaataaact
     8761 taaaacttta aaagaaaaaa aagaaattaa aaataaggct aaaacattac gaataaaaaa
     8821 tctaaaagaa gatttacata ttctttctga aaatttaaat ctttatcttg aattaaatga
     8881 agaatataaa aaactttata aagatggagt tataacaaac cttagtttgt tggaatacac
     8941 tgtaaaccct tctcgacaaa gacttttaaa attgaaaaaa cttaaagatt tgatttttga
     9001 aatcttttaa aaaattgtaa attttatgca aaaaacactt gatatattgt aaaaatatgg
     9061 tatagttaaa gtaaggtctt tttaaaagac taaaaatatt taagtttagg tctagcgtcc
     9121 taaacaaagg agttgtttta tgaaagattt attgaacaat gggtttcagc ctgtgtctga
     9181 aacggagatg gtaatggttg aggggggagg aggtgcttca gatatggtaa tagatggtga
     9241 taatcctgga gctcaaagac cgacacctcc accacctcct tctaatggcg gaggatgtgg
     9301 tgatgtaaat tggcttgaga tgagatagta actctaattt taggcctcct ccttacaatt
     9361 ctatatttta attgtaagga ggagttatcg atatgaaaaa acaattttta tttattttaa
     9421 tatttatttt tataattttt tttgcatgtt cggattatac aaatggcgat gaagtcagat
     9481 ttatttctta taaaaaaatg ctatccgatt atgaatattt ttgggatttt atttataaag
     9541 gctatccctt tagtgaagta tgtgagcgta atggtgccga tttaaagaaa atgaaaataa
     9601 aaaattatga gtccttatcg gggctggcct ctgaaaatgc ttatcttgcc ttttatgata
     9661 gactgtgcag acaaataacg ataggaaaat caatcggcca tttatatgct gtggataaat
     9721 atgattacaa atatgtattt aagacatcaa tgataggagg tccgtttatt actaagattt
     9781 tacttataga cggcttttat tctaaactga taggtggaag atcaagtact gaaattgaga
     9841 aaaatatatt ctattgcgat ttttttaatg atgagtttcc ttgttattcc tgtgatattt
     9901 atacagggtt tttaaaacgg ataatagaac ctggtaaaat agcttatgta aaattggatt
     9961 catttttgat agtaagtcgg gagatagaac ttcaatacct tagagattta aaagattttt
    10021 ttattgaaac tgccgattac aagcatatta ttatcgatat acaaaataac ggaggcggat
    10081 atattgaaaa ttatgaagca ataatatctc caaatataaa ggaaaatctg acaatagttt
    10141 cttatggtct ttataacgaa aataaatata cgaaccctta tttggaaatg ttttttaaag
    10201 gttatagaga tataaaaaag atagaaaaac atgaagttcc gaatatagaa aattgcggca
    10261 ctgtaaaaaa tgataaggct tataaattgg aagatatgat tgaaccttct tatattttag
    10321 attataaacc ttgtgaagat aaaaagtttt ggcttttagt aagcggtgat gtatattcag
    10381 cagcagatcg ttttacttat gtgtgtaaaa aaacgggttt tgctacagtt attggtacta
    10441 atacaaaagg agccggaaat aacggtttat ggcctatgta catcgttctt cccaacagcg
    10501 gtttattgat aaagtttgat tttatatatg gtctaaccga tgacggttat tgcacggatg
    10561 aattcggcac tgcccccgat atttataatc ttcccggtaa ggatgcttta gagacctgtt
    10621 tggaagagat acgaaagtta ggggaaaaga caaattaggg gagaggacaa acttttgatg
    10681 gagcaaaagt ttttcttctc ccctataacc cctcatcttt tcaaaacgcc atttaagagg
    10741 ggaacatttt ttagctcccc tcttaaaaat ctcccctaag ttagaggtat ggattgtcat
    10801 taagacaaac ctacggtttt tcttaataat cttttccctt tgcgttcctt gcggttatta
    10861 aaaaaataca aattgcaaat ttccaaaaga aacacttgac agattacaaa agtatgttaa
    10921 gattaaatat agtgtctgaa agagagatgc tgatggttga gggaggagca ggtgataatg
    10981 ggccgcaaaa aggtaaagat ccttcatgtc cattgcctga tgaaggaggt gggggtaaaa
    11041 taatacgacc tcctaggcct ggttcaggaa agaaagatcc agaaagtcct agtccttaa
//
