LOCUS       NC_009925.1            10831 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_009925.1 Acaryochloris marina MBIC11017, complete sequence.
ACCESSION   NC_009925
VERSION     NC_009925.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:03:05
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3047070
            Orig. end    :: 3057901
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10831
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3052070:3052901](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5831)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10831
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10831
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             499..990
                     /locus_tag="ctg1_2799"
                     /transl_table=11
                     /translation="MASTQLPSSEKSGERNHLSNEYLYETDFVKWIDKTAELLKQGKFS
                     ELDLENLIEEVESLGRHEKNALRSNLRVLLMHLLKWQYQPSKRSNSWRGTIIEHRIRIQ
                     DTLEDSPSLKNFYPQIFDKTYQQARNKAAEETGLPLETFPVESPYTSEQMLDAEFLPEE
                     "
     PFAM_domain     565..978
                     /aSDomain="DUF29"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01724.18"
                     /description="Domain of unknown function DUF29"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2799_0124"
                     /evalue="1.20E-56"
                     /label="ctg1_2799"
                     /locus_tag="ctg1_2799"
                     /protein_end="160"
                     /protein_start="22"
                     /score="190.9"
                     /tool="antismash"
                     /translation="LYETDFVKWIDKTAELLKQGKFSELDLENLIEEVESLGRHEKNAL
                     RSNLRVLLMHLLKWQYQPSKRSNSWRGTIIEHRIRIQDTLEDSPSLKNFYPQIFDKTYQ
                     QARNKAAEETGLPLETFPVESPYTSEQMLDAEFL"
     CDS             1147..2514
                     /locus_tag="ctg1_2800"
                     /transl_table=11
                     /translation="MSESAEILKQQFSQSLGLPWTDILLASRLEELLKEEAFSYRNRIY
                     SPIVTLWAMLYQVLSADKSLRNTVKCITTWLTAAGIQPPSSDTGAYSKARSRFPESLLQ
                     RLIPESAECLAQPLSPEHLWCGRPVKVYDGTTVLMADSAANQASYPQHGNQTAGCGFPI
                     ARLVVFFCLVTGAVASACIASWDTSEIVMSRLLYQDLEVGDVVMADQAYGSYVDLAIIQ
                     QHRADGVLRKHHARKTDFRKGNKHGIGDHQVTWHKPAQRPEHMSEQDFALIPQTLVVRE
                     VCLRLSLKGFRDQHIIVVTTLLDAQRYSAGQLTRLYGWRWPMAEVNLRHLKTTLKMEML
                     SAKTPDMVRKDIWVHLLGYNLLRSLMELAAPLADNARTQLSVQGARQHFNQMLALLATA
                     NRATRKRLFTHLLETMAADLLPSRPNRHEPRVVKRRPKSFPRMRQPRSALKAKLAV"
     PFAM_domain     1522..2229
                     /aSDomain="DDE_Tnp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01609.23"
                     /description="Transposase DDE domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2800_0125"
                     /evalue="2.60E-06"
                     /label="ctg1_2800"
                     /locus_tag="ctg1_2800"
                     /protein_end="361"
                     /protein_start="125"
                     /score="27.3"
                     /tool="antismash"
                     /translation="GRPVKVYDGTTVLMADSAANQASYPQHGNQTAGCGFPIARLVVFF
                     CLVTGAVASACIASWDTSEIVMSRLLYQDLEVGDVVMADQAYGSYVDLAIIQQHRADGV
                     LRKHHARKTDFRKGNKHGIGDHQVTWHKPAQRPEHMSEQDFALIPQTLVVREVCLRLSL
                     KGFRDQHIIVVTTLLDAQRYSAGQLTRLYGWRWPMAEVNLRHLKTTLKMEMLSAKTPDM
                     VRKDIWVHLLGYNL"
     CDS             2689..3168
                     /locus_tag="ctg1_2801"
                     /transl_table=11
                     /translation="MPRPLRIDICESEDTLKRLLRQQSSGRRKERLQALYWLKSGQVTT
                     RMELATLTGRGESTVYRWIKLYKSGGLQAMLEIPTSPGKPPMIGGEVLEKLKARLADPR
                     GFESYGAIQQWLLDECGLDVPYKTVHQTVHYRLKAKLKVPRPRSRKTEEAQQQAY"
     PFAM_domain     2776..2916
                     /aSDomain="HTH_28"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13518.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2801_0126"
                     /evalue="1.90E-08"
                     /label="ctg1_2801"
                     /locus_tag="ctg1_2801"
                     /protein_end="76"
                     /protein_start="29"
                     /score="34.4"
                     /tool="antismash"
                     /translation="ERLQALYWLKSGQVTTRMELATLTGRGESTVYRWIKLYKSGGLQA
                     ML"
     CDS             3194..3748
                     /locus_tag="ctg1_2802"
                     /transl_table=11
                     /translation="MTRYFAQGHPVRYWCMDESRWGLKTLTGRVLTLRGVKPVVTVQWP
                     REAFWLYGAVEPLTGDSFFYRFSHLDSVCFERFLEQFSLAFPQSLNLMQIDQAAAHMAT
                     WVRWPENVLPIVQPSHSPELNPAERLWQDLRKPFKGKNFDSIGALETALFEHINTLSQK
                     VVASLTGYSYILDALTIKVTQ"
     PFAM_domain     3230..3640
                     /aSDomain="DDE_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13358.8"
                     /description="DDE superfamily endonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2802_0127"
                     /evalue="4.80E-12"
                     /label="ctg1_2802"
                     /locus_tag="ctg1_2802"
                     /protein_end="149"
                     /protein_start="12"
                     /score="46.0"
                     /tool="antismash"
                     /translation="YWCMDESRWGLKTLTGRVLTLRGVKPVVTVQWPREAFWLYGAVEP
                     LTGDSFFYRFSHLDSVCFERFLEQFSLAFPQSLNLMQIDQAAAHMATWVRWPENVLPIV
                     QPSHSPELNPAERLWQDLRKPFKGKNFDSIGAL"
     CDS             complement(3760..4209)
                     /locus_tag="ctg1_2803"
                     /transl_table=11
                     /translation="MEAFDQINRSKYLYLESITEPEDNTLRLVLAEATANGPEHDMEIA
                     GTTISGLRNIETTEGCAIYEIFFAEYICYNVANESYADNAPQDNYVGKLARLYKSSAYL
                     EFMEVSTFATSDYPGPFSHYGFCCLNHCVDVISTTKPQIVCRVVT"
     CDS             complement(4216..5025)
                     /locus_tag="ctg1_2804"
                     /transl_table=11
                     /translation="MSTPPPELRELQRLFYGAISTKDADSIQQLQPQMRSTEHLSFERG
                     LSAYQGSVVGKLSRALEDIYPVCCRLVGVQFFTAMARQYIRRNPSQSHDLGDYGEQLPA
                     FIAAFEPAASLPYLPDVARLEWHWHCIFNSSDQPGLDLAALGQVPPDRWPELVLQLPDH
                     SVLMTSPYPVHRIWQVNQANAASTETIDLNEGDVNLFLWRDQYETRIDLPNVAEWQLLQ
                     AFASGAPFGEICAQFEHNDEIDVAALLPIWVQRGWISGFMLGLDENS"
     PFAM_domain     complement(4708..4998)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2804_0128"
                     /evalue="6.20E-20"
                     /label="ctg1_2804"
                     /locus_tag="ctg1_2804"
                     /protein_end="106"
                     /protein_start="9"
                     /score="71.3"
                     /tool="antismash"
                     /translation="ELQRLFYGAISTKDADSIQQLQPQMRSTEHLSFERGLSAYQGSVV
                     GKLSRALEDIYPVCCRLVGVQFFTAMARQYIRRNPSQSHDLGDYGEQLPAFI"
     CDS             complement(5001..5831)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2805"
                     /sec_met_domain="DUF692 (E-value: 1.3e-98, bitscore: 327.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAMTAIQGAGIGLRSQHYAHILTHQPAIPWLEALSDNYLGGGLP
                     LYHLEQIRAQYPITLHGVSLSLGSADPLNMDYLTQLKQLADRIEPVHVSDHLAWVSVNG
                     HYFNDLAPLPYTESVLHYVADRISQVQEFLGRRILIENLSPYLQFRHNSLTEWQFLAAL
                     LVEADCHLLLDINNVYVNATNHGFDPLDYLDALPVDRIKEIHLAGYEEQDHFLFDTHGY
                     PVQPGVWTLYQQALQRFGPVPTLIEWDTDIPSFDVLMAEAQQADTYLCQHRPQN"
     PFAM_domain     complement(5028..5807)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2805_0129"
                     /evalue="8.80E-108"
                     /label="ctg1_2805"
                     /locus_tag="ctg1_2805"
                     /protein_end="268"
                     /protein_start="8"
                     /score="359.6"
                     /tool="antismash"
                     /translation="GAGIGLRSQHYAHILTHQPAIPWLEALSDNYLGGGLPLYHLEQIR
                     AQYPITLHGVSLSLGSADPLNMDYLTQLKQLADRIEPVHVSDHLAWVSVNGHYFNDLAP
                     LPYTESVLHYVADRISQVQEFLGRRILIENLSPYLQFRHNSLTEWQFLAALLVEADCHL
                     LLDINNVYVNATNHGFDPLDYLDALPVDRIKEIHLAGYEEQDHFLFDTHGYPVQPGVWT
                     LYQQALQRFGPVPTLIEWDTDIPSFDVLMAEAQQADTY"
     CDS             complement(5902..6216)
                     /locus_tag="ctg1_2806"
                     /transl_table=11
                     /translation="MKTTTKAVAVTTALSGVLALGLVATQSDDAVAGKPGYEKCAGIVK
                     AGLNDCGTSKHDCSGKATVDNDPEEWIYVPAGTCEKIVGSTLKEAAPPAEAVEEGKKEG
                     "
     PFAM_domain     complement(5962..6105)
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2806_0130"
                     /evalue="1.50E-22"
                     /label="ctg1_2806"
                     /locus_tag="ctg1_2806"
                     /protein_end="85"
                     /protein_start="37"
                     /score="79.5"
                     /tool="antismash"
                     /translation="EKCAGIVKAGLNDCGTSKHDCSGKATVDNDPEEWIYVPAGTCEKI
                     VGS"
     CDS             6641..7153
                     /locus_tag="ctg1_2807"
                     /transl_table=11
                     /translation="VKKQALTLALASILIPASAYASDITTEEVEAAQAAWGNGIVEIGK
                     AEDPKQAAIAHIDKFYGFDMGSVLFKPTLASEDQFRGTKQEALSYFIGQDLKEDKGFAL
                     APYTKVRWENEGIIVDDDSAVAMGNYFFTKTDGEEVKVEFTLGYVKDENGNLKINLHHS
                     SLPYSAN"
     CDS             complement(7241..7501)
                     /locus_tag="ctg1_2808"
                     /transl_table=11
                     /translation="MDLFKASTPKADPEQIARLKAWVYEAFAIPADIPVSISQLACHEP
                     GCPPIETVIAIMTQPPQQYKLHQAVHEIAKPDVDALCKSLG"
     CDS             complement(7525..8574)
                     /gene_functions="other (smcogs) SMCOG1173:WD-40
                     repeat-containing protein (Score: 68; E-value: 1.1e-20)"
                     /gene_kind="other"
                     /locus_tag="ctg1_2809"
                     /transl_table=11
                     /translation="LPRVTQPRLGRKWRGRLDDYVTAIAWSPNSQQVAACDGAGNVQCL
                     NRITQQTHSLQTGTGQSVDALAYSADGRFLAAGGQDGRVSIWEMSGDAPTLFTCLENPR
                     TWVDQLAWHPRRPELVFSLGRYAQVWEVETQQVLTTLAFENSSVLDLAWHPQQDWLAVG
                     GHQGVKIWQDWDQDPAIRELPGSSICVSWSPDGQYLASGNLDRTMVVWPSEEDVPWRMT
                     GFPGKVRQIAWSADAESVDADPLLSAASGNCITTWHRLGSGWEAELLEEHTQAVNAIAF
                     QPNTTLLVSAAADDFLCLWQGGGKLVQAQKSISGSALAWSPDGQTLALGGQQGEWQLWT
                     QSARGQGFF"
     PFAM_domain     complement(7942..8034)
                     /aSDomain="WD40"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00400.34"
                     /description="WD domain, G-beta repeat"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2809_0133"
                     /evalue="1.90E-04"
                     /label="ctg1_2809"
                     /locus_tag="ctg1_2809"
                     /protein_end="211"
                     /protein_start="180"
                     /score="22.3"
                     /tool="antismash"
                     /translation="RELPGSSICVSWSPDGQYLASGNLDRTMVVW"
     PFAM_domain     complement(8062..8145)
                     /aSDomain="WD40"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00400.34"
                     /description="WD domain, G-beta repeat"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2809_0132"
                     /evalue="8.00E-03"
                     /label="ctg1_2809"
                     /locus_tag="ctg1_2809"
                     /protein_end="171"
                     /protein_start="143"
                     /score="17.1"
                     /tool="antismash"
                     /translation="ENSSVLDLAWHPQQDWLAVGGHQGVKIW"
     PFAM_domain     complement(8305..8502)
                     /aSDomain="ANAPC4_WD40"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12894.9"
                     /description="Anaphase-promoting complex subunit 4 WD40
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2809_0131"
                     /evalue="3.50E-05"
                     /label="ctg1_2809"
                     /locus_tag="ctg1_2809"
                     /protein_end="90"
                     /protein_start="24"
                     /score="24.1"
                     /tool="antismash"
                     /translation="AWSPNSQQVAACDGAGNVQCLNRITQQTHSLQTGTGQSVDALAYS
                     ADGRFLAAGGQDGRVSIWEMS"
     CDS             complement(8562..9530)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1178:cobalamin synthesis protein/P47K family protein
                     (Score: 395.1; E-value: 4.5e-120)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2810"
                     /transl_table=11
                     /translation="MVTAAIDTVPVTVLTGYLGAGKTTLLNRILTHEHGKKVAVIVNEF
                     GEVGIDNQLVIDADEEIFEMNNGCICCTVRGDLIRIIGNLMRRRDKFDHMVIETTGLAD
                     PAPVIQTFFVDEDMQTQLNLDAIVTVVDAKHIHQHWDADEAQEQIAFADVVLLNKTDLV
                     SEADLADLENRIRSMNAMTKIYRTQDAAVEMESILGVSAFDLDRALEIDPEFLGEDAHE
                     HDETVGSVALTESGEIDGERLNGWLGNLLQTKGPDIFRMKGILNIAGEDQRFVFQGVHM
                     LFDGRADRPWKASETRKNELVFIGRNLDEDQLRKGFQACLV"
     PFAM_domain     complement(8568..8849)
                     /aSDomain="CobW_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07683.16"
                     /description="Cobalamin synthesis protein cobW C-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2810_0135"
                     /evalue="3.70E-25"
                     /label="ctg1_2810"
                     /locus_tag="ctg1_2810"
                     /protein_end="321"
                     /protein_start="227"
                     /score="87.8"
                     /tool="antismash"
                     /translation="GSVALTESGEIDGERLNGWLGNLLQTKGPDIFRMKGILNIAGEDQ
                     RFVFQGVHMLFDGRADRPWKASETRKNELVFIGRNLDEDQLRKGFQACL"
     PFAM_domain     complement(8979..9503)
                     /aSDomain="cobW"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02492.21"
                     /description="CobW/HypB/UreG, nucleotide-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2810_0134"
                     /evalue="2.00E-62"
                     /label="ctg1_2810"
                     /locus_tag="ctg1_2810"
                     /protein_end="184"
                     /protein_start="9"
                     /score="210.1"
                     /tool="antismash"
                     /translation="PVTVLTGYLGAGKTTLLNRILTHEHGKKVAVIVNEFGEVGIDNQL
                     VIDADEEIFEMNNGCICCTVRGDLIRIIGNLMRRRDKFDHMVIETTGLADPAPVIQTFF
                     VDEDMQTQLNLDAIVTVVDAKHIHQHWDADEAQEQIAFADVVLLNKTDLVSEADLADLE
                     NRIRSMNAMTKI"
ORIGIN
        1 ccgttgcgat cttcatcccc agcaaagacg caacatcaca aacacagagt tcagttcctt
       61 cactcagggc atacaaaatc tttaatcggg accgatccgc taacgcactg aacagcactt
      121 gagcctccac cagcagatct tctcccggca gtgcttcatt cgcttgggtg accaagtctt
      181 ggttaaaaca acggacttgg caaatatctg tgggcttagt ctgggtcaca aatttgaagg
      241 gttacacctt acctgctctt agattttaac gaccaactgt tgaggcgttg tacccaatgc
      301 tgctatctaa aaggatgaaa tcgcagatac ctctatccag ggcacattca ggtttaagtt
      361 caggtaccct cgctgaggaa cgggttagga gataaaccag tctaatcaaa ggtctggatt
      421 tttgtgatcc agaactactc gtcaatgaaa tggttcgatg tgtcagatta gtgatgtaac
      481 caaagttttg gtgacgatat ggccagcacc caactcccta gctctgaaaa atctggtgag
      541 cgcaatcacc tatctaacga atatctctat gaaactgatt tcgttaaatg gatcgataaa
      601 acggctgagc tactgaagca aggtaaattt agtgagctag atcttgagaa tttaattgaa
      661 gaggttgaga gcttgggacg ccacgaaaag aatgcattga gaagtaatct ccgtgttctt
      721 ttaatgcatc tactcaagtg gcagtaccaa cccagtaaac ggagtaatag ctggcgcggg
      781 actatcattg agcatcggat tcgcatacag gacaccctag aagacagtcc cagccttaag
      841 aacttctatc cacagatttt tgataaaacc taccaacagg ctcgtaacaa agcagcagaa
      901 gaaacaggac ttcctctaga aacctttcct gtggagtccc cctacacgtc agagcaaatg
      961 cttgatgctg agtttctacc cgaagagtag caactgcatt ctatagtctc gtcagttaac
     1021 gttcaggaaa cgctgcatct gtcatctaac ggatcaatgg cactgactta agaagtcagg
     1081 aaaaggctac aagtcttgat agatatagga tcaagacttg cacgccataa acttctgcct
     1141 ttcactatgt ctgagtcagc cgaaattctc aagcagcaat tttcccaaag cctgggttta
     1201 ccgtggacag atatccttct agcctcaagg ttagaggaac tcctgaaaga agaagcattc
     1261 tcctatcgca accggatata tagccccatc gttacgctgt gggccatgct ttaccaagtg
     1321 ctatcagccg ataaaagcct tcgtaacaca gtcaaatgca tcacgacttg gctcacagcg
     1381 gctggcatcc aaccgccctc atctgatacc ggagcctaca gcaaagccag aagtcgcttt
     1441 ccagagtcac tgttgcaacg tttaattccc gaaagcgctg agtgcttagc gcaacccctc
     1501 tccccagagc acctctggtg tggtcggccc gtcaaggtct acgacggaac caccgtgttg
     1561 atggctgata gtgcggccaa ccaagcatca tatccacaac atggcaatca aacagcaggc
     1621 tgtggttttc ccatcgctcg cttggtagtg ttcttctgct tggttaccgg tgcagtggcg
     1681 tcagcttgta ttgcctcctg ggacaccagt gaaattgtca tgagtcgttt gctctatcaa
     1741 gaccttgagg tcggtgatgt ggtcatggcg gaccaagctt atggcagcta tgttgatcta
     1801 gccatcattc aacaacacag ggctgatgga gtgttgcgta aacatcatgc tcgcaagact
     1861 gatttccgca aaggcaacaa gcatggcatt ggtgatcatc aggtgacatg gcataagcca
     1921 gcccaacggc ctgagcacat gagtgagcaa gattttgccc tgattcctca aacattggtc
     1981 gttagagagg tgtgtttgcg cttatccctt aagggctttc gcgaccagca cattattgtg
     2041 gtgacgacgc tgctggatgc tcaacgctac agcgctgggc aactgactcg cttgtatggc
     2101 tggcgttggc caatggcgga agtcaatctg cgccatctca aaaccacctt aaaaatggag
     2161 atgctcagtg ccaaaactcc ggatatggtg cgcaaggaca tttgggtaca tttgttgggc
     2221 tataacctac tcagaagtct catggaactt gcggcaccgc tagcagataa tgctagaact
     2281 caactgtctg tgcaaggagc acgacaacac ttcaatcaga tgcttgcttt gttggcgaca
     2341 gccaaccgtg cgaccagaaa gcggttgttt actcatctac ttgagaccat ggcagccgat
     2401 ctattaccct ctcgaccgaa tcggcacgaa ccgagagtcg tcaaacgcag acccaaatct
     2461 ttcccgcgaa tgcgacaacc tcgctctgct ctcaaagcta agctagctgt ttgattgagc
     2521 ttaagtcagt gccattgatc taacggatag gtctcagggg tgcgagaatt atttcaaagc
     2581 attggcaaat agcttgtgcc gagcgtccct tgcagaccct tgtcatacca attccatata
     2641 tgtgtgactt gtattatggg agtagcgcgt tgctgatact tatccctcat gcccagaccc
     2701 ttacgaattg atatctgtga aagtgaagac acactcaaac gtttattacg tcaacaatcc
     2761 tccggtcgtc gcaaagaacg cttgcaagcc ctctactggc tcaaaagtgg tcaagtcacc
     2821 actcgcatgg agttggcaac cctgaccgga cgaggggaat ccacggtgta tcgctggatc
     2881 aaactctata aatcaggggg attacaggca atgctggaga ttcctacctc tcctgggaag
     2941 ccccccatga ttggtggaga ggtcctcgaa aagctgaaag ctcgtctagc tgaccccagg
     3001 ggctttgaga gctacggggc gattcaacaa tggcttttag atgagtgtgg attagacgta
     3061 ccctacaaaa cggttcatca aaccgtgcat tatcggctca aagccaagct caaagttcct
     3121 cgacctcgct cacgcaagac agaggaagct caacaacaag cctattaaaa aacttcctcg
     3181 tgtgattgag gtaatgaccc gctattttgc ccaaggacac ccagtgcgct actggtgcat
     3241 ggatgaaagc cgctggggac tcaagacact cacgggtcgg gttctaacgt tgcggggtgt
     3301 caaacctgtg gtgacggtac agtggccccg agaggctttc tggctctatg gcgctgtcga
     3361 acctctcaca ggagacagtt tcttctatcg gttttctcat ctcgatagtg tttgttttga
     3421 gcgcttcctg gagcaattca gcttggcgtt tccccagagt ctcaatctga tgcaaataga
     3481 tcaagccgca gcccatatgg cgacttgggt tcgatggcct gagaatgtgt tgccgattgt
     3541 acagccgtct catagtccag aactcaatcc ggcagagcga ttatggcagg acctaagaaa
     3601 gcctttcaaa ggcaaaaact ttgattctat tggggcactg gagaccgctt tatttgagca
     3661 tatcaatacc ctctcccaga aggtggtggc ttctctaacg ggatattctt atatcttgga
     3721 tgctttgact ataaaggtca ctcaataagt gaattggtat caggttacaa cacgacacac
     3781 aatctgtggc tttgtggttg aaataacatc aacgcaatga tttaggcaac aaaaaccata
     3841 gtggctgaat ggacctgggt agtcagaagt ggcgaacgtg ctaacctcca taaactctag
     3901 ataagccgaa cttttgtaaa gacgagctaa cttgccgacg tagttgtctt gaggtgcatt
     3961 atcggcataa gactcgttcg cgacgttgta acaaatgtac tcagcaaaaa atatttcata
     4021 aatagcacag ccttcggtag tttcaatgtt acgcagccca gatattgttg taccagctat
     4081 ttccatgtca tgctctgggc cattcgctgt agcttcggct aagactagac gtagagtatt
     4141 atcttctggt tcggtaattg attcgaggta cagatactta cttctgttga tttgatcgaa
     4201 agcttccatg agagcctaac tattctcatc taagccaagc ataaatccgg atatccatcc
     4261 tcgctgaacc cagattggaa gcaaggctgc cacgtcaatc tcatcgttgt gctcaaactg
     4321 ggcgcaaatc tctccaaacg gagcaccgga agcaaacgcc tgtaggagct gccactcagc
     4381 aacattgggc aagtcaatgc gggtttcata ctggtctcgc cagagaaaca gattcacgtc
     4441 gccttcattt agatcgatgg tctcggtact ggcggcattg gcctgattca cttgccaaat
     4501 tcggtgaacc ggataggggg aggtcattaa gacactatgg tcggggagtt ggagcaccag
     4561 ttcgggccaa cggtcaggcg gcacttgacc caaggccgcc aaatctaaac ccggttggtc
     4621 tgaactgtta aagatgcagt gccaatgcca ctctaagcgg gctacatccg gcagataggg
     4681 taacgaagcc gctggttcaa acgctgcgat aaatgccggg agctgttccc cataatctcc
     4741 gagatcgtgg gattgagagg gattgcggcg gatatattgc cgagccatgg cggtaaaaaa
     4801 ctggaccccc accaaccgac aacagacggg ataaatatct tcgagggcac ggctcaattt
     4861 accgacgacg ctgccttggt aagccgataa acctcgttcg aaggagaggt gttcagtgct
     4921 gcgcatttga ggttggagct gctggatgct gtcggcatct ttggttgaga tcgcaccata
     4981 aaacaaccgc tgtaactctc ttaattctgg gggcggtgtt gacatagata ggtgtcggcc
     5041 tgctgggctt cggccatcaa aacatcaaag ctgggaatat ccgtatccca ttcaatcaac
     5101 gtcggcaccg gaccaaaccg ctggagcgct tgctgataga gcgtccagac tccaggctgg
     5161 actggatagc cgtgggtatc aaataaaaag tggtcctgct cttcataacc cgctagatgg
     5221 atctctttaa tccgatcgac gggcaacgca tccagataat ccaaggggtc aaagccatga
     5281 ttggtggcat tgacatagac attgttaata tccaaaagca gatgacaatc ggcctcaact
     5341 aaaagggcgg ctaagaactg ccattcggtc aggctgttgt ggcgaaactg aagatagggc
     5401 gataggttct caatcaaaat ccggcgaccg agaaattcct gtacctgcga aatccgatcg
     5461 gcaacgtaat ggagcactga ttccgtatag ggcagcggtg ctaagtcatt gaagtaatgg
     5521 ccgttgacgg acacccaggc cagatgatca gagacatgaa ccggttcgat ccgatccgcc
     5581 agttgcttga gctgagttag gtagtccata ttcagcggat ctgctgaccc cagggacaga
     5641 ctaacgccat ggagggtgat cggatactgg gctcgaattt gttctaggtg atacaggggc
     5701 aatccacccc ccaaataatt gtcggagagg gcttctagcc agggtatggc tggttgatgg
     5761 gtgaggatat gggcgtaatg ttgcgatcgc aacccaatcc cagcaccctg aattgcagtc
     5821 atggcaacca taaaatactc caaaacgtaa ggtgcctgct tttcacaagc aggcactcaa
     5881 actttgcatg attgaaacga cctaaccttc tttcttgcct tcttcaaccg cttcagcagg
     5941 gggggcagct tctttcaagg tagatccaac aatcttttca caggtgccag caggcacata
     6001 aatccactct tctggatcat tatcaacggt ggctttacca gagcagtcat gcttgctagt
     6061 accacagtca ttgagaccag ccttgacgat accggcgcac ttttcataac cgggcttacc
     6121 agcaaccgca tcatccgatt gagttgccac taggccgaga gccagcacac cggataaagc
     6181 agtggtaaca gcaacggctt tagtcgtcgt tttcataatg gagaattcct tttaggattg
     6241 tgcattcttt gagcagcgta agccgacgct tggctgttgc tcacatatag aatacgagca
     6301 actcctccct ttggatgtag attgttcgag tttatcggcg tttgcaccca gattcgttgc
     6361 ctaaagagcg cttggagcat ggcgatggtc tctgactggc ctgcctccag agaaggagct
     6421 aagtcctgcg aacgcccaaa ggtacgctaa cggccatcac aaacccactg ccaaaaacaa
     6481 cagtagtttt gagaatatca ctgtgctttc ctctcgattg caccatggat caaatataaa
     6541 attctcctta aatcttataa aattgggatc gttcatatcc ttatagcctg gctgaaaaat
     6601 cagcacaggc ttaagttttt ttatttattt ggagataaaa gtgaagaaac aagcattaac
     6661 tcttgcttta gcgagtatcc tcatccctgc aagcgcttac gcttccgata tcaccactga
     6721 agaagtcgaa gcagcacaag ccgcgtgggg taatggcatt gtagaaatcg gtaaagctga
     6781 agaccctaaa caagccgcta tcgcccatat tgataagttc tatgggtttg atatgggttc
     6841 cgttttgttc aagcccacct tagcgtctga ggatcaattc cgagggacta agcaagaagc
     6901 tttgtcttat ttcatcggtc aagatttgaa ggaagacaag gggtttgccc ttgcacctta
     6961 cactaaagtt cgctgggaaa acgaaggcat catcgttgac gatgactcag ctgtagcaat
     7021 gggaaattac ttcttcacca aaaccgatgg tgaagaagtc aaagtggagt ttacccttgg
     7081 ttacgttaaa gatgaaaatg gcaacttaaa gattaatctg catcattcat ccctacccta
     7141 tagcgccaac taatacagct cagccttcat gaagcataac gccccgctgg ctcaggtcac
     7201 ggggcgttat atcactgaac aaaagaacac tcaccagacc ttaacccaaa gatttacaga
     7261 gagcatcaac atctggctta gcaatctcat gaacggcctg atggagctta tattgctgag
     7321 ggggctgggt catgatcgca atcaccgttt ctatcggtgg gcaacccggc tcatgacagg
     7381 ccaactgact aatggatacc gggatatccg caggaatggc gaaggcttca tacacccagg
     7441 ctttcagccg tgcaatctgt tctggatccg ctttaggcgt ggatgcttta aacaaatcca
     7501 ttagaactac tccccattca acaactagaa aaatccttga cctcgtgcac tttgggtcca
     7561 aagctgccat tctccttgct ggccccctaa agctagggtc tgaccatctg gactccaagc
     7621 cagggctgaa ccactgatac ttttttgcgc ttggactagc ttacccccac cttgccacag
     7681 acagagaaag tcatccgctg cagcagatac taaaagagtg gtattaggct gaaaggcaat
     7741 ggcattgact gcttgcgtgt gctcttctaa cagctctgct tcccagccac tgcctaggcg
     7801 gtgccaagtc gtaatgcagt taccactggc tgcggacagc agggggtcag catcaacgga
     7861 ttcagcatcc gctgaccagg ctatttgccg aactttgcca gggaaacccg tcatccgcca
     7921 gggtacgtct tcttctgaag gccacaccac catagtgcga tctaaatttc ctgacgctaa
     7981 atattgcccg tccggcgacc aagagacaca gatactcgat cctggaagct ctcgaatggc
     8041 gggatcttga tcccaatcct gccaaatttt gaccccttga tggccaccga ccgccagcca
     8101 atcctgttgc ggatgccagg ctaaatctaa aacggaagag ttttcaaagg cgagagtcgt
     8161 caggacttgc tgggtctcaa cctcccaaac ctgggcatag cgccccaggc taaacaccaa
     8221 ttctggacgc cgaggatgcc aggccagttg atccacccag gtgcgagggt tctctaaaca
     8281 ggtaaacagc gtcggtgcgt cgccgctcat ctcccaaatc gaaacacggc catcttgccc
     8341 tcctgctgcg agaaaacggc catcagcgga gtaagccaat gcatccactg actgtccggt
     8401 gcccgtttgc agactatggg tttgttgggt gattcgattg agacattgaa cattacccgc
     8461 tccatcgcag gcggccacct gctggctatt gggtgaccag gcaatggccg tcacataatc
     8521 atctaaacgc ccacgccatt tgcgtccaag tcgtggctga gttacacgag gcaagcttgg
     8581 aacccctttc ttaactgatc ttcatctaaa ttgcggccaa taaacaccaa ctcattcttg
     8641 cgggtttcgc tagccttcca agggcgatct gcacggccat caaacaacat atggaccccc
     8701 tgaaacacaa atcgctgatc ttctccggca atattcaaaa ttcccttcat ccgaaagata
     8761 tcaggcccct tggtttgcaa cagattgcct agccaaccgt tgagccgttc gccatcaatc
     8821 tcccccgatt ctgttaaggc caccgaccct acggtttcgt catgctcatg ggcatcttct
     8881 cccaaaaact cagggtcgat ctctaaagct cggtctagat caaaggcact cacacctaag
     8941 atggactcca tctccactgc cgcatcctga gtgcgataaa ttttggtcat ggcattcatg
     9001 gaccggattc gattttccag atccgccaaa tccgcttcgc tgactaaatc ggttttattg
     9061 agtaacacca catccgcaaa agcgatttgc tcctgggctt catccgcatc ccaatgctgg
     9121 tggatatgct tggcatccac gaccgtcact atcgcatcca gattgagctg ggtctgcata
     9181 tcttcatcca caaagaaggt ctggatcacc ggagctggat ccgctagccc tgtggtctca
     9241 atcaccatat ggtcgaactt atctcgtcgt cgcatcaagt tgccaataat ccgaatcaga
     9301 tcgcctcgca cggtgcaaca gatgcagcca ttgttcattt caaagatttc ttcatcggca
     9361 tcgatcacca gctgattatc aatgcccacc tcaccaaatt cattgacaat cacggctact
     9421 tttttgccat gttcgtgggt gagaatgcgg ttgagtaagg ttgtttttcc ggctcccaga
     9481 tagcccgtta gaacggtgac agggacggta tctattgcag cggtaaccat gacgatgacc
     9541 tcatcggaga atggttgaga taacgattat cattctacaa atatttcgac gtcagtttgg
     9601 cgactttacc ttagctttag cttttcaagg cgatgggata ggttctggat ttctcaccag
     9661 ccgatgccaa caaactgcat gagtgagtaa catcagttga tttaatcgca gatcagtagc
     9721 cgtttttgac tcacccagtc catctgttct gtgttgatga ttctctacct tgattcagtg
     9781 aatgatcgca attggggtgg aagtgagggt gttatgcgac acaatatcgg aataaccctt
     9841 tattttggag aattctccaa catctggcct ataatccact gagagaaggt gttatacgat
     9901 aggtggtacc tagcattact tatagatgtg ttatgcgata gcctgacgta tccatagtta
     9961 tgtacaagaa ccttcatcga aaatgattga gaaagatcat tgtgtaaact cttcgagacc
    10021 ctcaattgct cagtcaattg aactacagca tagataaaaa tatatgaatg ttgtttttat
    10081 tttgggaaat ggatttgatc ttaacctggg attaaacacc agctactccg atttttacaa
    10141 ctactataaa aaacaagttt catcaaacga agtaatcaaa gagttaaagg aaaatataga
    10201 ttcaaataca gaaaactggt ctgatctaga gcttcaattg gggcgctata cctcaagact
    10261 aaaagatcaa aatgacttcg atattttcta tttcgatata gtagacaatc taagagacta
    10321 tcttgatctt gaagaagata gttttgacta ctctgcattt gacaagtccg tattgttgag
    10381 agatcttgtt gagcctgaaa gagttttatc tcagagagaa agaaataaac taacagattg
    10441 gtatcgaaaa ttcggaggta atataaacac taacattttg acatttaatt atactcaaac
    10501 aattgaaaaa atacttggca aaaatgccac tagtcagccg attggcacaa ataataaagg
    10561 cgtacaagtt ttactaaata gtattgacca catacatgga tatcttgaag atggtctcgt
    10621 actaggagta aatgatgagg aacaaattga aaatgaaaaa ttacgtctgt ctcaggaggt
    10681 tgtcgaggcc attgttaagc ccatgcacaa tcaagagtta gggcatacga gagatgatcg
    10741 ctgcatgcaa gttatatctg cagcgaacct aatatttgtg tttggctgtt cgattggtaa
    10801 atctgatcag atgtggtggg aaaaagttgg c
//
