LOCUS       NC_018664.1            18069 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_018664.1 Gottschalkia acidurici 9a, complete sequence.
ACCESSION   NC_018664
VERSION     NC_018664.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:41:59
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 746580
            Orig. end    :: 764649
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     PFAM_domain     1..588
                     /aSDomain="Metallophos"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00149.30"
                     /description="Calcineurin-like phosphoesterase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_684_0053"
                     /evalue="5.90E-14"
                     /label="ctg1_684"
                     /locus_tag="ctg1_684"
                     /protein_end="196"
                     /protein_start="0"
                     /score="53.1"
                     /tool="antismash"
                     /translation="MSVYAISDLHLDFSKEKPMDVFGENWIKHEEKIFESWKSKVKEDD
                     LVLICGDISWGLKLEEAYKDLLRIDNLPGKKIISKGNHDLWWQTKAKLKELELKSIYFL
                     QNDNYQYENIAICGTRGWASKDSDEFSEHDEKIFAREVNRLDISLRTVEKGVDKKIVMI
                     HYPPFNFKDSSPNEFVDVMKKYNTDICIYGHLH"
     CDS             1..690
                     /locus_tag="ctg1_684"
                     /transl_table=11
                     /translation="MSVYAISDLHLDFSKEKPMDVFGENWIKHEEKIFESWKSKVKEDD
                     LVLICGDISWGLKLEEAYKDLLRIDNLPGKKIISKGNHDLWWQTKAKLKELELKSIYFL
                     QNDNYQYENIAICGTRGWASKDSDEFSEHDEKIFAREVNRLDISLRTVEKGVDKKIVMI
                     HYPPFNFKDSSPNEFVDVMKKYNTDICIYGHLHGEGHKFVVEGEIEGINFYCTSSDHLN
                     FDLKKII"
     protocluster    1..18069
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[755741:756320](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(9162..9740)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..18069
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18069
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="3"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             728..1183
                     /locus_tag="ctg1_685"
                     /transl_table=11
                     /translation="LSIDITEGIVWLSIAVACGIVEAITLGITSIWFVFGALAAWLLAE
                     INAPLPLQILTFLVVSSILLYFTKPLLKNKLKVGKEKTNTDLLIGEIGVVIKNIDMMRQ
                     EGQVNVKGQIWSAKTKDEEIIRANEKVEILGIEGVKLVVKKINKEEI"
     PFAM_domain     896..1162
                     /aSDomain="NfeD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01957.20"
                     /description="NfeD-like C-terminal, partner-binding"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_685_0054"
                     /evalue="1.70E-21"
                     /label="ctg1_685"
                     /locus_tag="ctg1_685"
                     /protein_end="145"
                     /protein_start="56"
                     /score="76.6"
                     /tool="antismash"
                     /translation="FLVVSSILLYFTKPLLKNKLKVGKEKTNTDLLIGEIGVVIKNIDM
                     MRQEGQVNVKGQIWSAKTKDEEIIRANEKVEILGIEGVKLVVKK"
     CDS             1184..2155
                     /locus_tag="ctg1_686"
                     /transl_table=11
                     /translation="MEGLLTFLLIFLIVIIVVSRNIRIVPQATAYVIERLGAYQGTWDV
                     GLHVKIPLIDRVANKVSLKEQVVDFPPQPVITKDNVTMKIDTVVYYQITDSKLYTYGVE
                     QPISAIENITATTLRNIIGDLELDETLTSRDTINTKMRSILDIATDPWGIKVNRVELKN
                     IIPPSEIQDAMERQMKAERERRESILRAEGEKKSSILVSEGRKESAILEAEAEKESAIL
                     RAEAKKEATIREAEGQAEAILKVQQATAEGLRMLNEAKPTKEVISLKSLEAFEKAADGK
                     ATKIIIPSEIQGLAGLATSLSEIVKEEKEESVVEESKKDKKQ"
     PFAM_domain     1253..1768
                     /aSDomain="Band_7"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01145.27"
                     /description="SPFH domain / Band 7 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_686_0055"
                     /evalue="3.50E-34"
                     /label="ctg1_686"
                     /locus_tag="ctg1_686"
                     /protein_end="195"
                     /protein_start="23"
                     /score="118.4"
                     /tool="antismash"
                     /translation="IVPQATAYVIERLGAYQGTWDVGLHVKIPLIDRVANKVSLKEQVV
                     DFPPQPVITKDNVTMKIDTVVYYQITDSKLYTYGVEQPISAIENITATTLRNIIGDLEL
                     DETLTSRDTINTKMRSILDIATDPWGIKVNRVELKNIIPPSEIQDAMERQMKAERERRE
                     SILRAEGEK"
     CDS             2342..3055
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 71.2; E-value: 1.6e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_687"
                     /transl_table=11
                     /translation="MARILIVEDESIIAKGLARIIESIDDELEVDITGYAEEALKYTKI
                     NEYDAFLIDIQLKDYSGFELSKEIRNIDIYKMTPIIFITAIPSRELMAFKEIHCYDYIV
                     KPFSEEQVRAALETVINYGIRNEDKKESLKLDQGGYSYIVEQDEIVYVEAKNRKLVITT
                     INETIDISGYTLYKLIEELTDDFIQCHRGYIVNVNYITKVDTANNLIDLKHTDLPIPIG
                     RKYKDCLRGKINEYN"
     PFAM_domain     2351..2689
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_687_0056"
                     /evalue="5.80E-19"
                     /label="ctg1_687"
                     /locus_tag="ctg1_687"
                     /protein_end="116"
                     /protein_start="3"
                     /score="68.4"
                     /tool="antismash"
                     /translation="ILIVEDESIIAKGLARIIESIDDELEVDITGYAEEALKYTKINEY
                     DAFLIDIQLKDYSGFELSKEIRNIDIYKMTPIIFITAIPSRELMAFKEIHCYDYIVKPF
                     SEEQVRAAL"
     PFAM_domain     2765..3037
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_687_0057"
                     /evalue="1.30E-17"
                     /label="ctg1_687"
                     /locus_tag="ctg1_687"
                     /protein_end="232"
                     /protein_start="141"
                     /score="63.9"
                     /tool="antismash"
                     /translation="YIVEQDEIVYVEAKNRKLVITTINETIDISGYTLYKLIEELTDDF
                     IQCHRGYIVNVNYITKVDTANNLIDLKHTDLPIPIGRKYKDCLRGK"
     CDS             3042..3158
                     /locus_tag="ctg1_688"
                     /transl_table=11
                     /translation="MSIIDGIIFSILDNIEYVIISHKLISGDKKIKLKTKKP"
     CDS             3192..3524
                     /locus_tag="ctg1_689"
                     /transl_table=11
                     /translation="MMGTSSEYLISVYSQRILSATLLICMTFLLYRRKLKETIYIYVIT
                     TIIMMLIQFGVFVTFNHLGKDLMLNFKDGMTAHSMILPLSIMVKKYIPIDVMFNYINKK
                     IKYLTV"
     CDS             3542..3787
                     /locus_tag="ctg1_690"
                     /transl_table=11
                     /translation="MLISLLAYWYIDIDGIFENVAAITIILIFIVVVNFIIIKNGLKNK
                     LEEEKLKTYEGYLPSVDKTVKKLRKNNMSVTIIFKS"
     CDS             3910..4743
                     /locus_tag="ctg1_691"
                     /transl_table=11
                     /translation="MGLIESIIMSTLDVLEYIIISSKLIQKDNICNHKNSKVILGIYIL
                     GFALAISFFAKYIAGKYSIVTSGILLVTMTFFVYRRKIKETIYTYIITMIVIISIQFSS
                     IVLLRIFIVDLDYSFTSGIFVHIVTLFLTSIIYMYVPIDMIFKYVNRDNKVFKLLVLNM
                     FIISISILLYWYVDVNGVFQNIAFLAAICSVIFVINLILLKNGLKNDIGEQKLKSYEGY
                     LPVVDKDLRKKQHQCDNYIQKLRMLIITSEEKGKIIDIDAINKKDIKEENKEIEN"
     CDS             4979..5812
                     /locus_tag="ctg1_692"
                     /transl_table=11
                     /translation="MGLIELIVMAMFDVVQYIILSGKLVHDRDVYTSKLNRLLLCICFL
                     GFSLSIGFSSYLLDGKYNIFVSGPLLMFMTFLIYRRKIRDTIYVYGITSIMMIIIQLSV
                     PVLLRMVSVELEFNFKSGLLAQTVTLFLAIIIALYVPVNSMFKYVIKGNKVFKFLGLNV
                     FIILVSLLMYWYIDIDTILKNIAIVSIVLIWTILVNFIILKNSLKNEIKEHNLKAYESY
                     LPAIDELIKDVRKKQHECDNHIQKLRMLAITGEENEEIIDSDIIKKEDMKRNSIE"
     CDS             6044..6862
                     /locus_tag="ctg1_693"
                     /transl_table=11
                     /translation="MGLLELIIMAMFDVAEYTIVSYKLIYDDMHSYKLNKLLLGLYFIG
                     FSLAIGFSSYLLNGKYNIFASCPLIIIMFFFIYRRKIKEIIYLYGISTVMMIIIQFASI
                     ILFRIFSVEIGFNFKSGLLAHTVTLLIIFTIVLYVPINSIFRYVREGNRVFKLLVLNIF
                     IIIVSLLFYWYVDIDSILKNVAIVAIILVWTILVNFIILRNGYKNQVEGEKLKAYEGYL
                     PTINELIKNLRKKQHECDNNIQVLRMTITENEDYKKSDYSEAKKENGKFK"
     CDS             7054..7764
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 69.6; E-value: 4.7e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_694"
                     /transl_table=11
                     /translation="MAKVLVVEDESIVAKGLATIVRSIDDTLEVNITGYAEEALKYANM
                     EYYDMFLLDIQLKDYSGLELAKEIRNIDIYKMTPIIFITAIPTNEIMAFKEIHCYDYII
                     KPFREEQVRTALETVINYGIKNEDKKEYLRLDQGRYSYSIDQNEIIYVESKSRKLIITT
                     INEAFKISTYTLYKLLDELSESFIQCHKSYIINMNYIEKIDTVDNLVTLKDIETSIPIG
                     RKYKDSLRGKTQCQ"
     PFAM_domain     7063..7401
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_694_0058"
                     /evalue="7.10E-19"
                     /label="ctg1_694"
                     /locus_tag="ctg1_694"
                     /protein_end="116"
                     /protein_start="3"
                     /score="68.1"
                     /tool="antismash"
                     /translation="VLVVEDESIVAKGLATIVRSIDDTLEVNITGYAEEALKYANMEYY
                     DMFLLDIQLKDYSGLELAKEIRNIDIYKMTPIIFITAIPTNEIMAFKEIHCYDYIIKPF
                     REEQVRTAL"
     PFAM_domain     7477..7746
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_694_0059"
                     /evalue="2.20E-19"
                     /label="ctg1_694"
                     /locus_tag="ctg1_694"
                     /protein_end="231"
                     /protein_start="141"
                     /score="69.6"
                     /tool="antismash"
                     /translation="YSIDQNEIIYVESKSRKLIITTINEAFKISTYTLYKLLDELSESF
                     IQCHKSYIINMNYIEKIDTVDNLVTLKDIETSIPIGRKYKDSLRG"
     CDS             7755..8009
                     /locus_tag="ctg1_695"
                     /transl_table=11
                     /translation="MSIIESIIMTMLDAIEYIIISGKLISGNKVYDLEKGKILFYIKNI
                     LVLSIIVGILGEFLPGKYSMVVISVISTVLITFVLYRKK"
     CDS             8039..9046
                     /locus_tag="ctg1_696"
                     /transl_table=11
                     /translation="MIIFLLIQFVVLITLNHLGIELDNSFNDGLTAHTIILPITIAISR
                     LLPINIVFNYVNKDNRVFKYLSLNIFIILISLLAYWYIDVNGVLKNIIAIAVVLTWVIL
                     VNFVLLKNGLKNELEEQQLRIYEEYLPVIDELISEIRKRQHEFDNHIQALKMITVTSED
                     YESVIGSMKHYMRDLEVTNDLKDLIKIDNKILAGFLYNKIKNAEKLDIQFDIIIQDYEF
                     NTGLKDYEVVEVMGNLINNAFETNIENNSVILIISKEKDMNVIEIRNKHPYLKKENLDK
                     IFSKGFSTKSSTGRGYGLYNVKKIVEKYNGKIEILNKSYRDENYVVFKVLFVRK"
     PFAM_domain     8717..8992
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_696_0060"
                     /evalue="6.10E-11"
                     /label="ctg1_696"
                     /locus_tag="ctg1_696"
                     /protein_end="318"
                     /protein_start="226"
                     /score="42.2"
                     /tool="antismash"
                     /translation="KDYEVVEVMGNLINNAFETNIENNSVILIISKEKDMNVIEIRNKH
                     PYLKKENLDKIFSKGFSTKSSTGRGYGLYNVKKIVEKYNGKIEILNK"
     CDS             complement(9029..9187)
                     /locus_tag="ctg1_697"
                     /transl_table=11
                     /translation="MKSLNPMFKKILRTICSFLILMVPLITTYVNCLGLWGEPEYPDLL
                     KNSFSNK"
     CDS             complement(9162..9740)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_698"
                     /sec_met_domain="AgrB (E-value: 4.1e-33, bitscore: 111.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIIVDKFHKYCENEFNLSELDSAKLKYSLQLITGNLSKLLILFFL
                     FSVLGYRKDFIYSFLSLLSIRIFTGGLHLKTYTGCLIFSAFFFCISIFLKNNIALNHSI
                     VTILFILSILITITMAPVCGKSRPDYSYAKRMQFKITGISFILIHFLMYFFKSNNSYFI
                     NAIWAMSLQCIQILIAKGGIVYEKFKPNV"
     PFAM_domain     complement(9216..9725)
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_698_0061"
                     /evalue="6.60E-32"
                     /label="ctg1_698"
                     /locus_tag="ctg1_698"
                     /protein_end="175"
                     /protein_start="5"
                     /score="110.4"
                     /tool="antismash"
                     /translation="KFHKYCENEFNLSELDSAKLKYSLQLITGNLSKLLILFFLFSVLG
                     YRKDFIYSFLSLLSIRIFTGGLHLKTYTGCLIFSAFFFCISIFLKNNIALNHSIVTILF
                     ILSILITITMAPVCGKSRPDYSYAKRMQFKITGISFILIHFLMYFFKSNNSYFINAIWA
                     MSLQCIQ"
     CDS             10618..12048
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 326.2; E-value:
                     7.4e-99)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_699"
                     /transl_table=11
                     /translation="MINLSRDQFEGLKASGKVFPVIVDYSGDQTTPINIFYNLDGKYKF
                     LLESAGTGEKQGRYSFLGQDPITTIKSDKTNIIVSSSDGEKSNQGNILNFIKDYLKVDY
                     EDCNSEIPFVGGLVGYIGYDVIRQIEDIDDNNSREINVPETYLLKYKIVICYDHLKRNI
                     SIIYNVYPEDSKNYEEILRGIEETYENITKLQEARKLEIVGKEKSFKSNFTKKEFCSAV
                     DKVRDYIKSGEASQIVISQRFTIDSNSEPFDVYRRLRSLNPSPYLFYIDYEDFQVVGAS
                     PESLVSLSGDKVITNPIAGTRKRGKTREEDIALREELINDPKEKSEHDMLVELGKEDLA
                     TVSKEGSIEVERYMEIENYSHVMHLVATVSGKLKEGLDSVDAFKSCFPAGTVSGSPRRR
                     SMEIIEELENVKREIYSGAVGYFSLNGDMDFCIGIRSIVFKDNKAYIQAGAGIVLDSKP
                     ENEYEETINKAKALIEVI"
     PFAM_domain     10699..11106
                     /aSDomain="Anth_synt_I_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04715.15"
                     /description="Anthranilate synthase component I, N terminal
                     region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_699_0062"
                     /evalue="1.90E-31"
                     /label="ctg1_699"
                     /locus_tag="ctg1_699"
                     /protein_end="163"
                     /protein_start="27"
                     /score="109.4"
                     /tool="antismash"
                     /translation="DQTTPINIFYNLDGKYKFLLESAGTGEKQGRYSFLGQDPITTIKS
                     DKTNIIVSSSDGEKSNQGNILNFIKDYLKVDYEDCNSEIPFVGGLVGYIGYDVIRQIED
                     IDDNNSREINVPETYLLKYKIVICYDHLKRNI"
     aSDomain        10699..12042
                     /aSDomain="TIGR00564"
                     /aSTool="tigrfam"
                     /description="trpE_most: anthranilate synthase component I"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_699_0015"
                     /evalue="2.80E-166"
                     /identifier="TIGR00564"
                     /label="ctg1_699"
                     /locus_tag="ctg1_699"
                     /protein_end="475"
                     /protein_start="27"
                     /score="552.0"
                     /tool="antismash"
                     /translation="DQTTPINIFYNLDGKYKFLLESAGTGEKQGRYSFLGQDPITTIKS
                     DKTNIIVSSSDGEKSNQGNILNFIKDYLKVDYEDCNSEIPFVGGLVGYIGYDVIRQIED
                     IDDNNSREINVPETYLLKYKIVICYDHLKRNISIIYNVYPEDSKNYEEILRGIEETYEN
                     ITKLQEARKLEIVGKEKSFKSNFTKKEFCSAVDKVRDYIKSGEASQIVISQRFTIDSNS
                     EPFDVYRRLRSLNPSPYLFYIDYEDFQVVGASPESLVSLSGDKVITNPIAGTRKRGKTR
                     EEDIALREELINDPKEKSEHDMLVELGKEDLATVSKEGSIEVERYMEIENYSHVMHLVA
                     TVSGKLKEGLDSVDAFKSCFPAGTVSGSPRRRSMEIIEELENVKREIYSGAVGYFSLNG
                     DMDFCIGIRSIVFKDNKAYIQAGAGIVLDSKPENEYEETINKAKALIEV"
     PFAM_domain     11260..12021
                     /aSDomain="Chorismate_bind"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00425.20"
                     /description="chorismate binding enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_699_0063"
                     /evalue="1.20E-91"
                     /label="ctg1_699"
                     /locus_tag="ctg1_699"
                     /protein_end="468"
                     /protein_start="214"
                     /score="307.0"
                     /tool="antismash"
                     /translation="KKEFCSAVDKVRDYIKSGEASQIVISQRFTIDSNSEPFDVYRRLR
                     SLNPSPYLFYIDYEDFQVVGASPESLVSLSGDKVITNPIAGTRKRGKTREEDIALREEL
                     INDPKEKSEHDMLVELGKEDLATVSKEGSIEVERYMEIENYSHVMHLVATVSGKLKEGL
                     DSVDAFKSCFPAGTVSGSPRRRSMEIIEELENVKREIYSGAVGYFSLNGDMDFCIGIRS
                     IVFKDNKAYIQAGAGIVLDSKPENEYEETINK"
     CDS             12165..13187
                     /locus_tag="ctg1_700"
                     /transl_table=11
                     /translation="MFSKSLNDILDGKNLTEENAQLIMHSIMQGELSESQISALLIGLR
                     MKGETVEEITGFARGMKNNARRVSVDSYSIDTCGTGGDGGKTFNISTAVSIVASAAGVS
                     VAKHGNRAVSSKSGSADVLVELGFNIDIDPHIAESCLKEKGMAFLFAPNYHTAMKNVAP
                     VRRDLGIRTIFNMLGPLSNPVDIKGQVLGIYDGRLTNTIANVLLKLGMERALVVHGDDG
                     LDEITTTTTTTVSEVRDGRVIDYKISPEEFGMSLADPKDISGGDAKENAEIILNILKGK
                     KGPERDIVVLNAGAALYVGKMASNLKEGIKLAEEVIDSGKALDKLNELIEYNRRILCLS
                     "
     PFAM_domain     12180..12353
                     /aSDomain="Glycos_trans_3N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02885.19"
                     /description="Glycosyl transferase family, helical bundle
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_700_0064"
                     /evalue="3.00E-18"
                     /label="ctg1_700"
                     /locus_tag="ctg1_700"
                     /protein_end="63"
                     /protein_start="5"
                     /score="65.5"
                     /tool="antismash"
                     /translation="LNDILDGKNLTEENAQLIMHSIMQGELSESQISALLIGLRMKGET
                     VEEITGFARGMKN"
     aSDomain        12183..13157
                     /aSDomain="TIGR01245"
                     /aSTool="tigrfam"
                     /description="trpD: anthranilate phosphoribosyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_700_0016"
                     /evalue="2.80E-131"
                     /identifier="TIGR01245"
                     /label="ctg1_700"
                     /locus_tag="ctg1_700"
                     /protein_end="331"
                     /protein_start="6"
                     /score="435.7"
                     /tool="antismash"
                     /translation="NDILDGKNLTEENAQLIMHSIMQGELSESQISALLIGLRMKGETV
                     EEITGFARGMKNNARRVSVDSYSIDTCGTGGDGGKTFNISTAVSIVASAAGVSVAKHGN
                     RAVSSKSGSADVLVELGFNIDIDPHIAESCLKEKGMAFLFAPNYHTAMKNVAPVRRDLG
                     IRTIFNMLGPLSNPVDIKGQVLGIYDGRLTNTIANVLLKLGMERALVVHGDDGLDEITT
                     TTTTTVSEVRDGRVIDYKISPEEFGMSLADPKDISGGDAKENAEIILNILKGKKGPERD
                     IVVLNAGAALYVGKMASNLKEGIKLAEEVIDSGKALDKLNELIE"
     PFAM_domain     12384..13133
                     /aSDomain="Glycos_transf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00591.23"
                     /description="Glycosyl transferase family, a/b domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_700_0065"
                     /evalue="1.30E-98"
                     /label="ctg1_700"
                     /locus_tag="ctg1_700"
                     /protein_end="323"
                     /protein_start="73"
                     /score="329.8"
                     /tool="antismash"
                     /translation="SIDTCGTGGDGGKTFNISTAVSIVASAAGVSVAKHGNRAVSSKSG
                     SADVLVELGFNIDIDPHIAESCLKEKGMAFLFAPNYHTAMKNVAPVRRDLGIRTIFNML
                     GPLSNPVDIKGQVLGIYDGRLTNTIANVLLKLGMERALVVHGDDGLDEITTTTTTTVSE
                     VRDGRVIDYKISPEEFGMSLADPKDISGGDAKENAEIILNILKGKKGPERDIVVLNAGA
                     ALYVGKMASNLKEGIKLAEEVIDSGKAL"
     CDS             13175..13957
                     /locus_tag="ctg1_701"
                     /transl_table=11
                     /translation="MFILDKIVEVKKKQLEIEKQEISLEEMIEKSKEDRIIRDFEDALD
                     NDDISVISEIKKASPSRGIIKEDFNPVFTAKIYEESPFNAISVLTEREFFLGDDKYINM
                     VKEVTTKPILRKDFIIDEYQIYQSKVIGADAILLIAAILKGKLKSYYDLAKSLGLHVLV
                     EVHGEDEIEEAIESGCRLIGINNRNLKTFDVDLKHTEKLIKLLPSDKIVISESGIKGYE
                     DMEYLKYLGVKGVLVGETLMRNLSNEPKSIILGDILTP"
     PFAM_domain     13184..13909
                     /aSDomain="IGPS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00218.23"
                     /description="Indole-3-glycerol phosphate synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_701_0066"
                     /evalue="3.60E-79"
                     /label="ctg1_701"
                     /locus_tag="ctg1_701"
                     /protein_end="245"
                     /protein_start="3"
                     /score="265.6"
                     /tool="antismash"
                     /translation="LDKIVEVKKKQLEIEKQEISLEEMIEKSKEDRIIRDFEDALDNDD
                     ISVISEIKKASPSRGIIKEDFNPVFTAKIYEESPFNAISVLTEREFFLGDDKYINMVKE
                     VTTKPILRKDFIIDEYQIYQSKVIGADAILLIAAILKGKLKSYYDLAKSLGLHVLVEVH
                     GEDEIEEAIESGCRLIGINNRNLKTFDVDLKHTEKLIKLLPSDKIVISESGIKGYEDME
                     YLKYLGVKGVLVGETLMRNL"
     CDS             14014..14634
                     /locus_tag="ctg1_702"
                     /transl_table=11
                     /translation="MVKIKVCGIRRNQDIEYVNTLRPEYIGFIFAESKRKVTKEEAFTL
                     KELLNKDIKTVGIFVNEDLKNVKDIANFVGLDIVQLHGDEDARYIDSLKSELINKSIWK
                     AVRIKDENSLKDIEQFNVDGILLDTYSKEAYGGLGESFDWNIVRNLKTNKKVILAGGLN
                     SDNVERGINKVRPDIIDVSSGVETDGYKDFNKMKSFIKKGRKL"
     PFAM_domain     14026..14616
                     /aSDomain="PRAI"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00697.24"
                     /description="N-(5'phosphoribosyl)anthranilate (PRA)
                     isomerase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_702_0067"
                     /evalue="3.70E-47"
                     /label="ctg1_702"
                     /locus_tag="ctg1_702"
                     /protein_end="201"
                     /protein_start="4"
                     /score="160.6"
                     /tool="antismash"
                     /translation="KVCGIRRNQDIEYVNTLRPEYIGFIFAESKRKVTKEEAFTLKELL
                     NKDIKTVGIFVNEDLKNVKDIANFVGLDIVQLHGDEDARYIDSLKSELINKSIWKAVRI
                     KDENSLKDIEQFNVDGILLDTYSKEAYGGLGESFDWNIVRNLKTNKKVILAGGLNSDNV
                     ERGINKVRPDIIDVSSGVETDGYKDFNKMKSFIK"
     CDS             14634..15836
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081:cysteine synthase (Score: 54.3; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_703"
                     /transl_table=11
                     /translation="MTNTIVKGKFGKFGGQYVAESVMNVLGELEVAFEEAKNDQSFADE
                     FNYYMKDYVGRENPLYYAENLSKKYGKAKIYLKREDLNHTGAHKINNAIGQVLLAKRMG
                     KKRIIAETGAGQHGVATATAAALFGMECEIFMGEEDTKRQALNVFKMEALGAKVNSVTT
                     GSKTLADAVDAALQDWVENIDTTFYILGSAVGPHPYPTIVKYFQSIISKEAKKQILEKE
                     NRLPDYVVACVGGGSNAIGMFSEFIEDEEVKLIGVEPAGLGLDTDKHAATMTKGSVGIL
                     HGMKTYVLQDEDGQILPVHSISAGLDYPGVGPEHSHLKDIGRAEYVSVTDDESVDALME
                     LTKVEGIIPAIESAHAVAHVLKLAKSLEEEKIIIISLSGRGDKDIARIARLKGVNVTDE
                     E"
     aSDomain        14655..15803
                     /aSDomain="TIGR00263"
                     /aSTool="tigrfam"
                     /description="trpB: tryptophan synthase, beta subunit"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_703_0017"
                     /evalue="7.40E-197"
                     /identifier="TIGR00263"
                     /label="ctg1_703"
                     /locus_tag="ctg1_703"
                     /protein_end="390"
                     /protein_start="7"
                     /score="652.0"
                     /tool="antismash"
                     /translation="GKFGKFGGQYVAESVMNVLGELEVAFEEAKNDQSFADEFNYYMKD
                     YVGRENPLYYAENLSKKYGKAKIYLKREDLNHTGAHKINNAIGQVLLAKRMGKKRIIAE
                     TGAGQHGVATATAAALFGMECEIFMGEEDTKRQALNVFKMEALGAKVNSVTTGSKTLAD
                     AVDAALQDWVENIDTTFYILGSAVGPHPYPTIVKYFQSIISKEAKKQILEKENRLPDYV
                     VACVGGGSNAIGMFSEFIEDEEVKLIGVEPAGLGLDTDKHAATMTKGSVGILHGMKTYV
                     LQDEDGQILPVHSISAGLDYPGVGPEHSHLKDIGRAEYVSVTDDESVDALMELTKVEGI
                     IPAIESAHAVAHVLKLAKSLEEEKIIIISLSGRGDKDIARIAR"
     PFAM_domain     14793..15770
                     /aSDomain="PALP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00291.27"
                     /description="Pyridoxal-phosphate dependent enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_703_0068"
                     /evalue="5.30E-50"
                     /label="ctg1_703"
                     /locus_tag="ctg1_703"
                     /protein_end="379"
                     /protein_start="53"
                     /score="170.6"
                     /tool="antismash"
                     /translation="VGRENPLYYAENLSKKYGKAKIYLKREDLNHTGAHKINNAIGQVL
                     LAKRMGKKRIIAETGAGQHGVATATAAALFGMECEIFMGEEDTKRQALNVFKMEALGAK
                     VNSVTTGSKTLADAVDAALQDWVENIDTTFYILGSAVGPHPYPTIVKYFQSIISKEAKK
                     QILEKENRLPDYVVACVGGGSNAIGMFSEFIEDEEVKLIGVEPAGLGLDTDKHAATMTK
                     GSVGILHGMKTYVLQDEDGQILPVHSISAGLDYPGVGPEHSHLKDIGRAEYVSVTDDES
                     VDALMELTKVEGIIPAIESAHAVAHVLKLAKSLEEEKIIIISLSG"
     CDS             15984..16784
                     /locus_tag="ctg1_704"
                     /transl_table=11
                     /translation="VLNRLDKRFKDLKERNEKALITFITSGVPDLETTEELVLEMEKAG
                     ADVVELGIPYSRPIADGKIIAEASKRALENGIKTSKVMEMVKNLREKTELPLVYLVYFN
                     TVFAYGVDRFLSKCNEVGIDGIIIPDLPIEERDEVLEACKENYVHLIPLVAPTSKDRIK
                     EITEGTGGFVYCVAVNGVTGTRDSINENIQEYMDTVSKFTDTPKAIGFGISSPEMAKEY
                     KDYSDGVIVGSAIVRKILEGNSREEIVKSISSFVKELKDAVLDK"
     aSDomain        16008..16763
                     /aSDomain="TIGR00262"
                     /aSTool="tigrfam"
                     /description="trpA: tryptophan synthase, alpha subunit"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_704_0018"
                     /evalue="1.50E-87"
                     /identifier="TIGR00262"
                     /label="ctg1_704"
                     /locus_tag="ctg1_704"
                     /protein_end="260"
                     /protein_start="8"
                     /score="290.7"
                     /tool="antismash"
                     /translation="FKDLKERNEKALITFITSGVPDLETTEELVLEMEKAGADVVELGI
                     PYSRPIADGKIIAEASKRALENGIKTSKVMEMVKNLREKTELPLVYLVYFNTVFAYGVD
                     RFLSKCNEVGIDGIIIPDLPIEERDEVLEACKENYVHLIPLVAPTSKDRIKEITEGTGG
                     FVYCVAVNGVTGTRDSINENIQEYMDTVSKFTDTPKAIGFGISSPEMAKEYKDYSDGVI
                     VGSAIVRKILEGNSREEIVKSISSFVKELK"
     PFAM_domain     16008..16772
                     /aSDomain="Trp_syntA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00290.22"
                     /description="Tryptophan synthase alpha chain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_704_0069"
                     /evalue="7.30E-88"
                     /label="ctg1_704"
                     /locus_tag="ctg1_704"
                     /protein_end="263"
                     /protein_start="8"
                     /score="293.9"
                     /tool="antismash"
                     /translation="FKDLKERNEKALITFITSGVPDLETTEELVLEMEKAGADVVELGI
                     PYSRPIADGKIIAEASKRALENGIKTSKVMEMVKNLREKTELPLVYLVYFNTVFAYGVD
                     RFLSKCNEVGIDGIIIPDLPIEERDEVLEACKENYVHLIPLVAPTSKDRIKEITEGTGG
                     FVYCVAVNGVTGTRDSINENIQEYMDTVSKFTDTPKAIGFGISSPEMAKEYKDYSDGVI
                     VGSAIVRKILEGNSREEIVKSISSFVKELKDAV"
     CDS             16834..17865
                     /locus_tag="ctg1_705"
                     /transl_table=11
                     /translation="MLKRKGIILTLVTVMILTLLSGCGTQKNNSDGSVNSSTGKDKKDI
                     IKIGEVQVTEYFGLDLSREGFRAALASRGYKEGENIEIEYANAQSDQSVGQNIAQSFAN
                     SNKDLIHAVATPVAQASYNATKDIPIVFTAVTDPVDAGIVKNLDKSGTNVVGMSDMVPM
                     KAQFNLIKKFFPEAKKLGIVYSSSDANSSVKVKEAKSIASEYGLEIIAQGAATTNDVGQ
                     TVESLLGKIDILYVPTDSTVVPAMPIIITKALEKKIPIIPEEKGQVELGALAAEGIDFY
                     KLGYESGLMAADILDGKSKPQDMPSKILEDRDIYVNKETLEKLGLTIPEDIKDKVKFVE
                     VKK"
     PFAM_domain     16981..17832
                     /aSDomain="ABC_sub_bind"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04392.14"
                     /description="ABC transporter substrate binding protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_705_0070"
                     /evalue="3.80E-75"
                     /label="ctg1_705"
                     /locus_tag="ctg1_705"
                     /protein_end="333"
                     /protein_start="49"
                     /score="252.9"
                     /tool="antismash"
                     /translation="EVQVTEYFGLDLSREGFRAALASRGYKEGENIEIEYANAQSDQSV
                     GQNIAQSFANSNKDLIHAVATPVAQASYNATKDIPIVFTAVTDPVDAGIVKNLDKSGTN
                     VVGMSDMVPMKAQFNLIKKFFPEAKKLGIVYSSSDANSSVKVKEAKSIASEYGLEIIAQ
                     GAATTNDVGQTVESLLGKIDILYVPTDSTVVPAMPIIITKALEKKIPIIPEEKGQVELG
                     ALAAEGIDFYKLGYESGLMAADILDGKSKPQDMPSKILEDRDIYVNKETLEKLGLTIPE
                     DIK"
     CDS             17926..18069
                     /locus_tag="ctg1_706"
                     /transl_table=11
                     /translation="MLTLVRNEKPIKGGRVMFRLTLVKSIKGKLNKYNNLKNYIIIHDL
                     YR"
ORIGIN
        1 atgtcagtat atgcaatatc agatctgcac ttggattttt cgaaagaaaa gccaatggat
       61 gtgtttggtg agaattggat taaacatgaa gaaaagatat ttgaaagttg gaaaagtaaa
      121 gttaaagaag atgatttagt acttatatgt ggagatatat cctggggact aaagttagaa
      181 gaagcatata aagacttatt aagaatagat aatctgcctg gcaagaagat tataagtaag
      241 ggaaatcatg atttatggtg gcaaactaaa gctaagttaa aagagcttga attaaaatct
      301 atatattttc ttcaaaatga taattatcaa tatgaaaata tagcgatatg tggtactaga
      361 ggatgggcat ctaaagatag tgatgaattc agtgaacatg atgagaaaat atttgccaga
      421 gaagttaata gattagatat ttcactcaga actgtggaaa aaggtgttga taagaagata
      481 gttatgatac attatccacc gtttaatttt aaagatagtt cacctaatga atttgtagat
      541 gtaatgaaaa agtataatac agatatatgt atttatggac atttacatgg cgaagggcat
      601 aagtttgtag tagaaggtga aatagaaggt ataaactttt actgcacatc tagtgatcat
      661 ttaaattttg atttaaaaaa gataatttga aattatatga tataatataa agaaaggggt
      721 gtttatcttg tcgattgata taacagaagg aattgtatgg ttatcaatag cagtagcatg
      781 tggtatagtt gaggctataa cattaggaat aacgagtata tggttcgtat tcggagcatt
      841 ggcagcatgg ctattagccg aaattaacgc tcctcttccg ctacaaatac taactttttt
      901 agtggtatct agcattttac tatactttac taagccattg ctaaaaaata aattaaaagt
      961 aggcaaagaa aagactaata cagatttact aataggcgaa attggagtag ttataaagaa
     1021 catagacatg atgagacaag aaggtcaagt aaacgtaaaa ggtcaaatct ggtctgctaa
     1081 aactaaagat gaagaaatta taagagcaaa tgaaaaagta gaaattctag gaatagaagg
     1141 agtaaaatta gtggtaaaga aaataaataa ggaggagatt taaatggaag gactattaac
     1201 ttttttatta atttttttaa tcgtcatcat tgttgtatct agaaatatca gaatagtacc
     1261 acaagccaca gcatacgtta ttgaaagatt aggtgcgtat caaggaacat gggatgttgg
     1321 acttcatgtg aaaattccac taatagacag agtggctaat aaagtttcat taaaagaaca
     1381 agttgtggat tttccaccgc aaccagttat aactaaagac aacgtaacta tgaagataga
     1441 tacagtagta tactaccaaa taacagactc aaagctttac acttatgggg tagagcaacc
     1501 tatatcagct atagaaaata taacagctac aacacttaga aatataatag gggatttgga
     1561 gctagacgaa acacttacat caagagatac tataaatact aaaatgagaa gtatactaga
     1621 cattgctaca gatccttggg gcattaaagt aaatagggta gaacttaaaa atataatacc
     1681 accttcagaa attcaagatg caatggaaag acagatgaag gcagagagag aaagaagaga
     1741 atctatatta agagcagaag gagaaaagaa atcttcaata ctagtttcag aaggtagaaa
     1801 agaatctgct atattagaag ctgaggctga aaaagagtca gcaattctta gagcagaagc
     1861 taaaaaagaa gcaactataa gagaagcaga aggtcaggct gaagctattt taaaagtaca
     1921 acaagcaaca gcagaaggtc ttagaatgtt aaatgaagca aaaccaacta aagaagttat
     1981 atcattaaaa agtttagagg cattcgaaaa ggctgcagat ggaaaagcaa ctaagattat
     2041 aataccatct gagatacaag ggttagcagg gcttgctact tcacttagtg agattgtgaa
     2101 agaggaaaaa gaagaaagtg tagtagaaga aagtaaaaag gataaaaaac aataaattta
     2161 taaatatatg atgtaattaa gaaaatgccc tataagatat acaatataaa atagtatatt
     2221 ttatggggta tttatatgta tattgtcaat aaaagaagaa ttttgactat aataattgtg
     2281 tttagaatac ttttccaata taattagaat tatagatgca ctaatatata gaggtgattt
     2341 aatggctaga atattaattg tagaagatga aagtataatt gcaaaaggat tagcaagaat
     2401 tatagaaagt atcgatgatg aactggaggt agatataaca ggttatgctg aagaagctct
     2461 aaagtacact aagataaatg aatacgatgc atttttaata gatattcagc ttaaagatta
     2521 ctcaggattt gaactatcta aggaaataag aaatatagac atatataaaa tgacccctat
     2581 tatatttatt actgcaattc catcaagaga acttatggct tttaaagaaa tacattgtta
     2641 tgactatata gtaaaacctt tttcagaaga acaagtaaga gcagcactag aaacagtaat
     2701 taattatgga attaggaatg aagataaaaa agagagcctt aagttagatc aaggtggata
     2761 ttcttacatt gtggagcaag atgaaatcgt ctatgttgaa gctaagaata gaaaactagt
     2821 aattacaact attaatgaaa ctatagatat atctgggtat acattgtaca agctcataga
     2881 agaattaaca gatgatttta tacagtgcca tagaggatat atagttaatg taaattatat
     2941 tacaaaagta gatacggcaa acaatcttat agatcttaag catacagacc taccaatacc
     3001 tataggaaga aaatataaag attgtctgag aggtaaaata aatgagtata attgatggaa
     3061 ttatattttc aatactagat aatatagaat atgtaattat ctcccataaa ttaataagtg
     3121 gagataaaaa aattaaactt aaaacgaaaa aaccctaatt atatagtgta gttatattaa
     3181 tacaagcaat aatgatgggg acttcaagtg aatatctaat aagcgtatat agtcaaagga
     3241 tattatcagc aactttgttg atatgtatga catttttatt atatagaaga aagctaaaag
     3301 aaactatata catatatgtt attacaacaa taattatgat gttaattcag tttggtgttt
     3361 ttgtaacatt caatcattta ggaaaagatt taatgcttaa ttttaaagat ggaatgactg
     3421 ctcattctat gatattgccg ttaagtatca tggtcaaaaa gtacataccg attgatgtca
     3481 tgtttaatta cataaacaaa aaaataaaat atttgactgt ttagtattaa atgcattcat
     3541 tatgctaata tctttattag catactggta tatagatatt gatggtattt ttgaaaatgt
     3601 agctgctata actattattc ttatatttat tgttgtagtt aattttataa ttataaagaa
     3661 tgggctaaag aataagctag aagaggaaaa acttaaaact tatgaaggat acctaccttc
     3721 tgtagataaa actgtaaaga aacttagaaa aaacaacatg agtgtgacaa tcatattcaa
     3781 aagttaagaa tgcttgcact cacaaatcaa gaaaatgaga agatagaaga aagtagtgat
     3841 gattaatttt taatataatt taatgaatca ttaaggtaaa aatataaggg agtatacgag
     3901 attaaataaa tgggactaat agaatctatt ataatgagta cacttgatgt cttagaatac
     3961 ataattatat caagtaaatt aatacaaaaa gataatatat gtaatcataa aaatagtaaa
     4021 gtaatactgg gtatatatat tctaggattt gctttagcta tatcattctt tgctaaatac
     4081 atagctggaa agtatagtat agttacgtca ggaatcttac ttgtaactat gacttttttt
     4141 gtatacagaa gaaaaataaa agagactata tatacatata taattactat gatagtaatt
     4201 atatcaatac aattttcttc gatagtatta cttagaatct ttatagtaga cctagattat
     4261 agttttacaa gtggaatttt cgttcatatt gttacattgt ttttgactag tattatatac
     4321 atgtatgtac ctattgacat gatatttaaa tatgtaaata gagataataa agtttttaaa
     4381 ttattagtgc taaatatgtt cattatatct atttcaatat tactatactg gtatgtagat
     4441 gttaatggag tattccaaaa tatagccttt ttagcagcta tttgttcagt gatatttgtt
     4501 ataaacctta tattgttgaa gaatggactt aaaaatgaca taggggaaca aaaactcaaa
     4561 tcttatgaag gatatttacc agtcgttgat aaagacctta gaaagaaaca acatcagtgt
     4621 gataactaca ttcaaaagtt aagaatgctt ataattacaa gtgaagagaa aggaaaaatt
     4681 atcgatattg atgctataaa taaaaaagat ataaaagagg aaaataaaga aattgagaat
     4741 taataaacta acaattatat gatataatta gaaaaatgcc ccttaatatg atatttttat
     4801 aatatcatat taaggggcat ttacgtttac atgatataaa aaattttata ttgctatctt
     4861 gattgcattt ttagcctttc ttaaatataa ttagaatcat gatagataat tttgtctaaa
     4921 taaaagttca agaatttttg taagaaaaaa tgaaaaaaat tataaaaaag gagaaactat
     4981 gggattaata gagttaattg taatggctat gtttgatgta gttcaataca ttattttatc
     5041 aggtaaacta gtacatgata gggatgtata tacttctaaa ttaaatagac tgttactttg
     5101 tatatgtttt ttaggatttt cactatctat aggattttct tcataccttt tagatggcaa
     5161 atataatatc tttgtttcag gacctttgct tatgtttatg acttttttaa tatatagaag
     5221 gaagataagg gacacaattt acgtatatgg aattacttcg ataatgatga taataattca
     5281 attatccgtt ccagttttac ttagaatggt tagcgtagag ctagaattta actttaaatc
     5341 tggtcttctt gctcaaactg ttacgttgtt tttagctatc attatagctt tatatgtacc
     5401 agttaactct atgtttaaat atgtaatcaa agggaataaa gtcttcaagt ttttaggatt
     5461 aaatgtattt atcatattag tatcactatt gatgtactgg tatatagata tagatactat
     5521 actaaaaaat atagctatag tatctattgt tcttatatgg actatcctag tcaattttat
     5581 aatattaaag aatagtctta aaaatgaaat aaaagaacac aatctcaaag cttatgagtc
     5641 atacttacca gctatagatg aattaataaa ggatgttaga aagaagcaac atgaatgtga
     5701 caatcatatt caaaagttaa gaatgcttgc aatcacaggt gaggagaatg aagaaattat
     5761 cgacagtgat attataaaga aagaagatat gaaaagaaat tcaatagagt aagataaaaa
     5821 gttgatgaga aataaattaa gaagtatata gcggactaga cgactaccat taatataagt
     5881 cagaaatata tactaactct acagatttga tttagtattc taaatactag acttatagaa
     5941 taaaaggttt actacagctg aatattctag aaaactttat ctgagtggcg ctttaaggtt
     6001 tctaccaaga tgaaagtaaa aagttttatc aaagggtgaa gttatgggat tattagaatt
     6061 aattataatg gctatgtttg atgtagctga atacacaatt gtatcatata aactaatata
     6121 tgatgatatg catagttata aattaaataa attattgctt ggcttatatt ttattgggtt
     6181 ttcgctagct ataggatttt cttcgtatct tttaaacggt aaatataata tatttgcatc
     6241 atgtccgtta attattatta tgtttttctt tatatataga agaaaaataa aagagataat
     6301 atatttatat ggaatttcta ctgtaatgat gattattatt caatttgcct ctataattct
     6361 atttagaatt tttagcgtcg agattgggtt taattttaaa tctggacttc ttgctcatac
     6421 agttacatta ctcataattt ttactatagt tttatatgta cctattaact ctatatttag
     6481 atatgtaaga gaaggtaaca gggtctttaa acttttagta ttaaatattt ttattataat
     6541 agtgtcatta ttattctatt ggtatgtaga tattgatagt atattaaaaa atgtagccat
     6601 agtagccatc attcttgttt ggactatttt agttaatttt ataatattaa ggaatggata
     6661 taaaaatcaa gtagagggtg agaagcttaa ggcctatgag ggatacttac caactataaa
     6721 tgaactcata aaaaatctta gaaaaaaaca acatgagtgt gataataaca tacaagtatt
     6781 aagaatgaca ataactgaaa atgaagatta taaaaagtct gattatagtg aagctaaaaa
     6841 agaaaatgga aaatttaagt agtaataagc taaagtataa ataataaaat tagaattatt
     6901 tatctaatat tgagagcata aaaagtctat ttttaaaagt atttgttcat atttgacata
     6961 aaaagaacct ttttatcgag atattaattg catttataat gttttttaaa tataattaga
     7021 actgcaagtg ctataagata tagaggtgat ttaatggcta aggtactagt cgtagaagat
     7081 gagagcatag tagcaaaagg attagcaact attgttagaa gtattgatga tacattagag
     7141 gtcaatataa ctggatatgc tgaagaggct ttaaagtacg cgaatatgga gtattatgat
     7201 atgtttttac tagatattca acttaaagac tattcggggc ttgaattagc taaagagata
     7261 aggaacatag atatctataa aatgacccct attatattta ttactgcaat tcctacaaat
     7321 gagattatgg cttttaagga aatacactgt tatgattata taataaaacc ttttagagaa
     7381 gaacaagtaa gaacagcatt agaaactgta atcaattatg gaattaagaa tgaagataaa
     7441 aaagaatatc ttagactaga tcaaggaagg tattcttata gtatagatca aaatgaaatt
     7501 atttatgtcg aaagtaaaag cagaaagtta ataattacaa ctattaatga agcttttaaa
     7561 atatctacgt acacactata taagctttta gatgagttat cagaaagttt tattcagtgc
     7621 cataagagct atataattaa catgaattat attgaaaaga tagatacagt agataattta
     7681 gtaacgctta aagatataga aacatcaata ccaataggaa gaaaatataa ggatagcttg
     7741 agagggaaga cacaatgtca ataattgaat caattataat gacaatgctt gatgcgatag
     7801 agtatataat tatatcaggt aagttaataa gtggtaacaa ggtatatgac cttgaaaaag
     7861 ggaaaatact gttctatatt aaaaatattt tagtattatc aatcatagtg ggaatattgg
     7921 gtgaatttct acccggtaaa tatagtatgg tggtaatatc agtgatatca acggtactta
     7981 ttacatttgt actttatagg aaaaaataaa agaaactatt tatatatatt tgattagtat
     8041 gataattttt ttactgattc aatttgtagt cttaataact ttaaatcatt taggcataga
     8101 attagataat agttttaatg atggacttac agcacatact attatattgc caataactat
     8161 tgctataagt agacttttac caattaatat agtgtttaat tatgtcaata aagataatag
     8221 agtatttaag tatttgtccc taaacatatt tattatacta atatctttac ttgcatattg
     8281 gtatatagac gttaatggag tcttgaaaaa tatcattgct atagctgttg tgctgacatg
     8341 ggttatttta gtaaactttg tgttactgaa gaatggactt aaaaatgagt tggaagaaca
     8401 gcaattaagg atttatgaag agtacttgcc agttattgat gaacttataa gtgaaatcag
     8461 aaaaagacag catgaattcg ataatcatat acaggcacta aagatgatta cagtaacaag
     8521 tgaagattat gaaagtgtta tcggatctat gaaacattac atgagagatt tagaagttac
     8581 taatgactta aaagatttaa ttaaaattga taataaaata ttagctggat ttttatataa
     8641 taaaattaaa aatgctgaga aactggacat tcaatttgat attataatac aagactatga
     8701 atttaatact ggtctaaaag attatgaggt agttgaagtt atggggaatt taattaataa
     8761 tgcatttgaa actaacatag aaaataactc tgttatactt ataatatcaa aagaaaaaga
     8821 tatgaatgtt attgaaatta gaaataaaca tccatatcta aaaaaagaaa atctagataa
     8881 aatttttagt aaaggatttt ctactaaatc ctctactgga agaggatatg gcttgtacaa
     8941 tgtaaagaaa atagttgaaa aatataatgg gaaaattgag atattaaaca aatcatatcg
     9001 tgatgaaaat tatgttgttt ttaaggtgct atttgttaga aaatgagttt tttaatagat
     9061 caggatactc tggctcaccc cataaaccaa gacaatttac gtaagtagtt attaaaggta
     9121 ccattaaaat taaaaagcta catatagttc ttaaaatttt tttaaacatt gggtttaaac
     9181 ttttcataaa caatgcctcc ttttgctatc aatatttgaa tacactgtaa agacatagcc
     9241 catatagcat taataaaata tgaattatta cttttaaaaa agtacattaa aaaatgaata
     9301 aggataaatg atatacctgt tattttaaat tgcatcctct tcgcataaga ataatcaggt
     9361 ctagattttc cacacactgg agccatagtt atagttataa gtatagataa tataaataaa
     9421 atagttacta ttgaatgatt aagagcaatg ttattcttta agaatataga tatgcaaaag
     9481 aaaaaggcag agaatattaa gcatccagta tatgttttta aatgtaatcc tcctgtaaat
     9541 atccttattg ataataaaga taagaaagaa taaataaaat cttttctgta tcctaatact
     9601 gagaataaaa aaaacagtat tagaagttta gatagattac cggttataag ttgcaatgaa
     9661 tattttaact tagcactgtc aagttcagaa agattaaact cattttcgca gtatttatga
     9721 aatttatcta caataatcac taaaatcacc cattatctat tgtattttta ttatcaatat
     9781 accatagaat atagggttat aaacacaaac gggatgaacg acacgtttag acgtatgaat
     9841 gacatgtatg aacgacatgt ttagatgtat gaacgacaaa aaataaaaaa taaaatgtta
     9901 ttcatactgt tttaaatgct gtttgtccaa atgtattgta aaaatagtca ctaaagtgtt
     9961 aaagtactaa ttgaggggat gaatatttaa tctttcaagt taagtaatat ttgttactta
    10021 catgaaaacg tcaaggggat attgggaatt taagaacatt ataaaaagcg tagagtattg
    10081 gggaagtaaa ttttacgctt tttataatgt tttattttat tttattaaaa aagtgttgac
    10141 acaaataata tagctgtata taatgataag aaataaagtt gttaagtaat taaaatctat
    10201 gaaacagaga gagtaaatat ggatgtttag tcgaagcgag tctagggtgg tgaaagctag
    10261 atactgtagt ctatattgaa tgggtctgtg agatggtgtg tgaattatag tagcattacc
    10321 cggaggtcta ccgttaacaa gacagggtat cgatatgtat ctgtacctga tagagataag
    10381 tttgtactta ggtggcataa cgaatgtata gcatttcgtc ctaaaaaagg gtgaagtgct
    10441 tttttttata gaaatatgct atttaaatac aaataaaata tgggtggcac cacgagtcac
    10501 ttcgtcccat gaactatgga cgaagtggct ctttttgtat atccaattat ctgattatca
    10561 gaagcttgtc gattcctaaa atcatataaa attaaatttg atttgggggg aattataatg
    10621 attaatttat cgagagatca gtttgaaggt ttaaaagcaa gtggaaaggt gttcccggta
    10681 atagttgact acagtggaga tcagacaacg cctataaata tcttttacaa cttagacgga
    10741 aaatacaaat ttttattaga aagtgctggg actggtgaaa aacaggggag atattcattt
    10801 ttaggtcagg atcctataac tactataaaa agtgataaaa caaacataat tgtaagtagt
    10861 tcagacggtg aaaaaagtaa ccaaggaaat atactaaact ttataaaaga ttatttaaaa
    10921 gtagattatg aagactgtaa ttcagaaatt ccttttgtag gtggtttagt aggatatata
    10981 ggttatgacg ttataagaca aatagaagat atagatgata acaattcaag agaaataaat
    11041 gttccagaga cttatttgct aaagtacaaa atagttatat gctacgatca tcttaaaaga
    11101 aatatttcta taatatacaa tgtttatcct gaagatagta aaaattatga agaaatatta
    11161 agagggatag aagagactta tgaaaatata acaaagttac aggaagcaag aaagttagaa
    11221 atagtaggca aagagaagtc gtttaaatct aactttacta aaaaggagtt ttgtagtgca
    11281 gtagataaag taagggatta tataaaaagt ggggaagcat ctcaaatagt aatttcacaa
    11341 agatttacta tagattcaaa ctcagaacca tttgatgttt atagaagact tagaagttta
    11401 aatccatcac catatttatt ctatatagat tatgaagatt ttcaagttgt tggagcttca
    11461 ccagagagct tagtaagttt aagtggagat aaagttatta caaatccaat agcaggtacc
    11521 agaaaaagag ggaaaacaag agaagaagat atagcattaa gagaagaact tataaatgat
    11581 cctaaagaaa agtcagagca cgacatgtta gtagagcttg gaaaagaaga cttagctaca
    11641 gtaagtaaag aaggaagcat agaagtagaa agatatatgg aaatagaaaa ctattcacat
    11701 gtaatgcact tagtagcaac tgtatctgga aagctaaaag aagggttaga ttcagtagat
    11761 gcatttaaat catgttttcc agctggaaca gtatctggat cgcctagaag aagatcaatg
    11821 gaaataatag aggaacttga aaatgttaaa agagaaatat attcaggagc agtaggatac
    11881 ttttctctaa atggagatat ggacttctgt ataggaataa gaagtatagt atttaaagac
    11941 aacaaggcat atatacaagc gggggcaggc atagtactag actctaagcc agaaaatgag
    12001 tatgaagaga ctataaataa agctaaagct ttaatagaag ttatataaat aaagaattat
    12061 ttactcagtg aaaggtagaa ggctgaaatt tcttataaac agagttagag taattgacca
    12121 aaaatcaatt ttaatacaaa tactttgctt aagggggaag atatatgttt agtaagtctt
    12181 taaatgatat attagatggg aaaaatttaa cggaagaaaa tgcacaacta ataatgcatt
    12241 caataatgca aggagaacta tcagaatcac aaatatctgc actactaata gggttaagaa
    12301 tgaaaggtga aacggtagaa gaaataacag ggtttgctag aggtatgaaa aacaatgcta
    12361 gaagagtaag tgtagatagc tatagtatag atacttgtgg aactggtgga gacggaggaa
    12421 agactttcaa tatatcaaca gcagtatcta tagtagcatc cgctgcgggg gtttcagtag
    12481 caaagcatgg aaacagggcg gtatctagta aaagtggaag tgctgatgta ttagtagaat
    12541 taggctttaa tatagatata gatccacata tagctgaaag ttgcttgaaa gaaaaaggta
    12601 tggcattttt atttgcacca aactatcata cagctatgaa gaatgtagca ccagtaagac
    12661 gtgacttagg aataagaaca atatttaata tgctgggtcc attaagtaat ccagtagata
    12721 taaaaggtca agttctagga atttatgatg gaaggcttac taacactata gcaaatgtgt
    12781 tgctaaagtt aggaatggaa agagcattag tggtacatgg agatgatggg ctagacgaaa
    12841 taacaacgac aacgactact acagtaagtg aagttagaga tggaagagta atagattaca
    12901 agataagtcc agaggaattc ggaatgagtc ttgcagatcc aaaagacata tctggtggag
    12961 atgcaaaaga aaatgcagag ataatactaa acatcttaaa aggaaaaaaa ggtccagaaa
    13021 gagatatagt agttcttaat gctggagcag cattatatgt aggaaagatg gctagtaact
    13081 taaaggaagg aataaagtta gcagaggaag taatagattc aggaaaagca ctagataaat
    13141 taaatgaact aatagagtac aataggagga tattatgttt atcttagata aaatagttga
    13201 ggttaaaaag aagcagctag agattgaaaa gcaagaaatt agtctagaag aaatgataga
    13261 aaaatctaag gaagatagaa ttataagaga ttttgaagat gcactagaca atgatgatat
    13321 atcagttata tctgaaataa aaaaggcatc accttctaga ggaataataa aagaagattt
    13381 taacccagtt tttacagcaa aaatatatga agaaagtcca ttcaatgcta tatcagtttt
    13441 aacagaaaga gagttttttc taggtgatga taagtatata aatatggtta aagaagtaac
    13501 tactaagcct atattaagaa aagactttat aatagatgaa tatcaaatat atcaatcaaa
    13561 ggtgatagga gcagatgcaa tacttttaat agcagctata ttaaaaggaa aacttaaaag
    13621 ctattatgat ttagctaaaa gtctaggact tcatgtgtta gtagaggttc atggagaaga
    13681 tgaaatagaa gaagctatag aaagtggatg tagattaata ggaataaaca acagaaatct
    13741 aaaaaccttt gatgtagatt taaagcatac tgagaagcta ataaaactac tacctagtga
    13801 taaaatagtt atttcagaaa gtggaattaa gggttatgag gatatggaat acttaaaata
    13861 cttaggagta aaaggagtac ttgtaggaga aacacttatg agaaatttaa gtaatgaacc
    13921 aaagtctata attttaggcg atatacttac tccataatca taaggaattt agtatcttta
    13981 caatacagca tataaaaagg atgtaattat attatggtta aaataaaagt ttgtgggata
    14041 agaagaaatc aagatataga gtatgtaaat actttaaggc cagaatatat aggatttata
    14101 tttgcagaaa gtaagagaaa agtgactaaa gaggaagctt ttactctaaa agaattacta
    14161 aataaagata ttaaaactgt gggtatattt gtaaatgaag atttaaaaaa tgtaaaagac
    14221 atagctaact ttgtaggttt agacatagta caattacatg gagatgaaga tgcaagatat
    14281 atagatagtc ttaaaagcga acttataaat aaaagtattt ggaaagctgt tagaataaaa
    14341 gatgaaaata gtttaaaaga tatagaacag ttcaatgtag atggaatact tttagatact
    14401 tactctaaag aagcatatgg tggacttgga gaatcatttg attggaatat agtgaggaac
    14461 ttaaagacaa acaaaaaagt tattttagcg ggtggactta attctgataa tgtagaaaga
    14521 ggcataaaca aggtgcgccc tgatataata gatgtttcta gtggtgtaga aacagatgga
    14581 tataaagatt ttaataaaat gaaaagtttc ataaaaaaag ggaggaagtt ataatgacaa
    14641 atacgatagt taagggtaag tttggaaaat tcggaggaca atatgtagca gaatcagtaa
    14701 tgaatgtttt aggagaatta gaggtagcat ttgaggaagc taagaacgac caaagctttg
    14761 cagatgaatt taattactat atgaaagatt atgtaggaag agaaaatcca ttatactatg
    14821 cagaaaatct ttcaaaaaaa tatggaaaag caaaaatata cttaaaaaga gaagatttaa
    14881 accatacagg agcacacaaa ataaataacg ctataggtca agtacttcta gctaaaagaa
    14941 tgggtaaaaa aagaataatc gcagaaacag gagcaggtca acatggagtt gcaacagcta
    15001 cagcggcagc actatttggt atggaatgtg aaatatttat gggagaagaa gatacaaaaa
    15061 gacaggcact taacgtattt aaaatggaag ctctaggagc taaagttaac tctgtaacta
    15121 caggaagtaa aactctagca gatgctgtag acgcagcatt acaagattgg gtagaaaata
    15181 tagatactac attctatatc ttaggttcag cagtaggacc acatccatat ccaactatag
    15241 tgaaatactt ccaaagtatt atctctaaag aagctaaaaa acaaatatta gagaaagaaa
    15301 acagattacc agactatgta gtagcttgtg taggtggagg aagtaatgct attggaatgt
    15361 ttagtgaatt tatagaagat gaagaagtaa aattaatagg ggtagaacca gcaggtcttg
    15421 gattagacac tgataaacat gcagctacaa tgacaaaagg aagtgttgga atattacacg
    15481 gaatgaagac atacgtactt caagatgaag atggtcaaat attaccagta cactctatat
    15541 cagcaggatt agactatcca ggagtaggac ctgagcattc tcacttaaaa gatatcggaa
    15601 gagcagaata tgttagcgta acagatgatg aatcagttga tgctcttatg gaattaacta
    15661 aagtagaagg tataatacca gctattgaaa gtgcgcatgc agtagcacat gtattaaaac
    15721 ttgcaaaatc attagaagaa gaaaagataa taataatctc actttcaggt agaggagata
    15781 aagatatagc tagaatagca agattaaagg gagtaaatgt aacagacgaa gaataagaaa
    15841 cgagttaatt aagcagatga cccaacatat tcttgttggt gtcaattgct taattttaaa
    15901 tatttagtgg ttaaggggag gttagtttac ttaaagaaca ataaaagtgg tattttgagt
    15961 gagcaaatat aaaggggctg aaggtgttga atagattaga taaaagattt aaggatttaa
    16021 aggaaagaaa tgaaaaagct cttattacat ttataactag tggagttcca gatcttgaaa
    16081 ctacagaaga actagttctc gaaatggaaa aggcaggagc agatgtagtg gaacttggta
    16141 ttccatattc tcgccctata gctgacggta aaattatagc agaagcatct aaaagagctt
    16201 tagaaaacgg aattaagaca tctaaagtta tggaaatggt aaagaattta agagagaaaa
    16261 cagaattacc actagtttac ctagtatatt ttaatactgt atttgcttac ggtgtagata
    16321 gatttctaag taaatgcaat gaggtaggaa tagatggaat aatcatacct gatcttccga
    16381 tagaagaaag ggatgaagtg ctagaagctt gtaaagaaaa ctatgttcac ttaataccgt
    16441 tagtagcacc tacatctaaa gatagaataa aagaaataac tgaaggtaca ggtggatttg
    16501 tttactgtgt agcagtgaat ggggttactg gaactagaga tagtataaat gaaaatattc
    16561 aagaatatat ggacacggta tcaaaattta cagacacacc aaaagctata ggatttggta
    16621 tatcaagtcc agaaatggct aaggagtata aggactactc agatggagta atagtaggaa
    16681 gtgcaatagt tagaaaaata ctagagggaa atagtagaga agagatagtg aaaagtataa
    16741 gcagttttgt aaaagaatta aaagatgctg tattagataa atagtatact tgtacgatat
    16801 attcatgtag tcataaaaag gaaggtggat caaatgttaa aaagaaaagg tataatatta
    16861 acgttagtaa ctgtaatgat attgacttta ctatcaggat gtggaactca gaaaaacaat
    16921 agtgatggta gtgttaattc aagtacaggt aaagataaaa aagacattat aaagataggt
    16981 gaagttcagg ttacagaata ctttggactt gatttaagtc gtgagggatt tagagcagcc
    17041 ctggcatcta gaggctacaa agagggagaa aatattgaaa ttgagtatgc aaatgcgcaa
    17101 agtgaccaga gtgtaggaca aaatatagct caaagttttg caaatagtaa taaagatctt
    17161 atacatgctg tagcaacacc tgttgcacag gcatcatata atgcaactaa agatatacca
    17221 atagtattta cagcagttac agatcctgta gatgcgggaa tagttaaaaa tctagacaaa
    17281 tcaggtacta atgttgtagg aatgtcagat atggttccta tgaaagcaca atttaactta
    17341 attaaaaaat tctttccaga agcaaaaaaa ctagggatag tttatagttc tagtgatgca
    17401 aattcatcag taaaagtaaa ggaagcaaaa tctatagcta gtgaatatgg acttgaaata
    17461 atagcacaag gagctgcaac tactaatgat gtaggtcaaa cagtggaatc gctgttagga
    17521 aaaatagata tattatatgt accaacagat agcacagtgg ttccagcaat gcctattatc
    17581 ataacaaaag cattagaaaa gaaaattcca ataataccag aggaaaaagg tcaagtagag
    17641 cttggagctt tagcagcgga aggaatagat ttttataagt taggatatga aagtggtctt
    17701 atggcagcag atatattaga tggtaaaagt aaacctcaag atatgccatc taagatatta
    17761 gaagataggg atatatatgt aaataaagaa acactagaga agttaggatt gactataccg
    17821 gaggatataa aagataaagt taaatttgta gaagttaaaa agtagtttta tattatgtta
    17881 aaattatgtt acaaataaaa aagtagttga attaggaaat tatatatgct aacattagtt
    17941 agaaatgaaa aaccaataaa aggaggtcgt gttatgttta ggttaacact tgttaaatct
    18001 atcaaaggca aattaaataa atataataac ttaaaaaatt atataattat acacgacctt
    18061 tatcgttaa
//
