LOCUS       NZ_CP064875.1          10246 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP064875.1 Bacillus toyonensis strain P18 chromosome, complete
            genome.
ACCESSION   NZ_CP064875
VERSION     NZ_CP064875.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:56:40
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2561487
            Orig. end    :: 2571733
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10246
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2566487:2566733](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5246
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10246
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10246
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             242..1156
                     /gene_functions="transport (smcogs) SMCOG1166:transporter,
                     EamA family (Score: 198.9; E-value: 2e-60)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2445"
                     /transl_table=11
                     /translation="MLNKKWDLQIICAHAFTILIWGTAFPAIRMGLESYTPEHLTLLRL
                     LIASFILLVFSFIYKLRLPDLKDIPAIFIFGALGFTIYHIALNYGEKTVNAGSASLIIS
                     VTPIVTAILASVFLNEKMKLNGWIGGVISFIGIALISFSQGGSIQFNSGGLFILLAAVS
                     ESLFFVFQTSYLKKYGFLLFTIYTILSSTVCMLIFLPGIYTEILAAPLEVNVSVIYLGL
                     FPTVLPYLALAYIISRAGASEATSSLYLTPVTACFIAWVWLGEVPTFISVIGDGITILG
                     ILIAHIRVVSKEKHRNLVNNKSI"
     PFAM_domain     287..667
                     /aSDomain="EamA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00892.22"
                     /description="EamA-like transporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2445_0176"
                     /evalue="1.70E-29"
                     /label="ctg1_2445"
                     /locus_tag="ctg1_2445"
                     /protein_end="142"
                     /protein_start="15"
                     /score="102.8"
                     /tool="antismash"
                     /translation="FTILIWGTAFPAIRMGLESYTPEHLTLLRLLIASFILLVFSFIYK
                     LRLPDLKDIPAIFIFGALGFTIYHIALNYGEKTVNAGSASLIISVTPIVTAILASVFLN
                     EKMKLNGWIGGVISFIGIALISF"
     PFAM_domain     695..1093
                     /aSDomain="EamA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00892.22"
                     /description="EamA-like transporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2445_0177"
                     /evalue="8.30E-18"
                     /label="ctg1_2445"
                     /locus_tag="ctg1_2445"
                     /protein_end="284"
                     /protein_start="151"
                     /score="65.0"
                     /tool="antismash"
                     /translation="SGGLFILLAAVSESLFFVFQTSYLKKYGFLLFTIYTILSSTVCML
                     IFLPGIYTEILAAPLEVNVSVIYLGLFPTVLPYLALAYIISRAGASEATSSLYLTPVTA
                     CFIAWVWLGEVPTFISVIGDGITILGILI"
     CDS             1295..2656
                     /locus_tag="ctg1_2446"
                     /transl_table=11
                     /translation="MNRKRNIFTCLSIIGIGLASVSNSSFAANVTDSSVQHSIPVMNQQ
                     VAVAKEMKPFPQQVNYAGVIKPNHVTQESLNASVISYYDNWKKKYLKNDLSSLPGGYYV
                     KGEITGDADGFKPLGTSEGQGYGMVITVLMAGYDSNAQKIYDGLFKTARTFKSSQNPNL
                     MGWVVADNKKAQGHFDSATDGDLDIAYSLLLAHKQWGSNGSVNYLKEAQNMITKGIKAS
                     NVTNNNRLNLGDWDSKSSLDTRPSDWMMSHIRAFYEFTGDKTWLTVINTLYDVYTQFNN
                     KYSPNTGLISDFVVKNPPQPAPKDFLDESKYTNSYYYNASRVPLRIVMDYAMYGEKRSK
                     VISDKVSSWIQNKTNGNPSKIVDGYQLNGSNIGSYSTAVFVSPFIAASITSNNNQKWVN
                     SGWDWMKNKRESYFSDSYNLLTMLFITGNWWKPVPDDKEIQNLINDEMYEGYDK"
     PFAM_domain     1541..2566
                     /aSDomain="Glyco_hydro_8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01270.19"
                     /description="Glycosyl hydrolases family 8"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2446_0178"
                     /evalue="2.00E-27"
                     /label="ctg1_2446"
                     /locus_tag="ctg1_2446"
                     /protein_end="424"
                     /protein_start="82"
                     /score="96.0"
                     /tool="antismash"
                     /translation="YDNWKKKYLKNDLSSLPGGYYVKGEITGDADGFKPLGTSEGQGYG
                     MVITVLMAGYDSNAQKIYDGLFKTARTFKSSQNPNLMGWVVADNKKAQGHFDSATDGDL
                     DIAYSLLLAHKQWGSNGSVNYLKEAQNMITKGIKASNVTNNNRLNLGDWDSKSSLDTRP
                     SDWMMSHIRAFYEFTGDKTWLTVINTLYDVYTQFNNKYSPNTGLISDFVVKNPPQPAPK
                     DFLDESKYTNSYYYNASRVPLRIVMDYAMYGEKRSKVISDKVSSWIQNKTNGNPSKIVD
                     GYQLNGSNIGSYSTAVFVSPFIAASITSNNNQKWVNSGWDWMKNKRESYFSDSYNLLTM
                     LF"
     CDS             2820..3743
                     /locus_tag="ctg1_2447"
                     /transl_table=11
                     /translation="LEKVLFFGDPGIDDSFAIMYGLLHPEIEIVGIVTGYGNVEHIHAA
                     HNAAYILQLANRQDIPVISGATKPLTEEISTYYPEIHGLEGLGPIHVPESVLSIPIYNF
                     GSIAAILVKYGKDLTIVDVGRSTSLAIAFNLWNDLILNVKGIYFMGGVFLEVGNVTPLA
                     EANVYGDPIASKIVFQQAKNLFIFPLNVTNKAVLTPNVFNYIQANSKNPFHTIMKPMYD
                     YYLSAYQKLNPSIEGPLLHDVVAISGLVNPSFFEFAHRTVNVDTYGDTKGQTFADFRPN
                     SKSEGARIALEIDAEKFIQDFIKIML"
     PFAM_domain     2835..3716
                     /aSDomain="IU_nuc_hydro"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01156.21"
                     /description="Inosine-uridine preferring nucleoside
                     hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2447_0179"
                     /evalue="8.60E-64"
                     /label="ctg1_2447"
                     /locus_tag="ctg1_2447"
                     /protein_end="299"
                     /protein_start="5"
                     /score="216.1"
                     /tool="antismash"
                     /translation="FFGDPGIDDSFAIMYGLLHPEIEIVGIVTGYGNVEHIHAAHNAAY
                     ILQLANRQDIPVISGATKPLTEEISTYYPEIHGLEGLGPIHVPESVLSIPIYNFGSIAA
                     ILVKYGKDLTIVDVGRSTSLAIAFNLWNDLILNVKGIYFMGGVFLEVGNVTPLAEANVY
                     GDPIASKIVFQQAKNLFIFPLNVTNKAVLTPNVFNYIQANSKNPFHTIMKPMYDYYLSA
                     YQKLNPSIEGPLLHDVVAISGLVNPSFFEFAHRTVNVDTYGDTKGQTFADFRPNSKSEG
                     ARIALEIDAEKFI"
     CDS             3820..4278
                     /locus_tag="ctg1_2448"
                     /transl_table=11
                     /translation="LNVQLKVVTRENWEDALKLQVKENQLKFVPSVAVSLAKVYIKPDG
                     DNVEYIPFAIYDGDLMVGFVMHAVVIESSDMYWINGFIIDQSQQGNGYGKAALQESIYL
                     IKNTFKACKEIRLTVHKDNICAKKLYENYGFQPLGHDYDGEEVYRVFV"
     PFAM_domain     3964..4224
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2448_0180"
                     /evalue="6.40E-10"
                     /label="ctg1_2448"
                     /locus_tag="ctg1_2448"
                     /protein_end="135"
                     /protein_start="48"
                     /score="39.4"
                     /tool="antismash"
                     /translation="EYIPFAIYDGDLMVGFVMHAVVIESSDMYWINGFIIDQSQQGNGY
                     GKAALQESIYLIKNTFKACKEIRLTVHKDNICAKKLYENYGF"
     CDS             4356..4802
                     /locus_tag="ctg1_2449"
                     /transl_table=11
                     /translation="LKSKFHHIVRAVVIKDEKLLVAEYIGHHYFLPGGHVEIGESAEHA
                     LIRELREELGVNCSIKQFLGVIENRWQDKGMLHHEINHIFEVSSKELYIDLSPKSRESH
                     LAFHWIDYSKESLKTYKIMPMPSVKELLERKLSDELLNCWISNF"
     PFAM_domain     4374..4700
                     /aSDomain="NUDIX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00293.30"
                     /description="NUDIX domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2449_0181"
                     /evalue="2.10E-15"
                     /label="ctg1_2449"
                     /locus_tag="ctg1_2449"
                     /protein_end="115"
                     /protein_start="6"
                     /score="57.0"
                     /tool="antismash"
                     /translation="HIVRAVVIKDEKLLVAEYIGHHYFLPGGHVEIGESAEHALIRELR
                     EELGVNCSIKQFLGVIENRWQDKGMLHHEINHIFEVSSKELYIDLSPKSRESHLAFHWI
                     DYSKE"
     aSDomain        5001..5237
                     /aSDomain="TIGR03601"
                     /aSTool="tigrfam"
                     /description="B_an_ocin: bacteriocin,
                     heterocycloanthracin/sonorensin family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2450_0036"
                     /evalue="2.00E-34"
                     /identifier="TIGR03601"
                     /label="ctg1_2450"
                     /locus_tag="ctg1_2450"
                     /protein_end="79"
                     /protein_start="0"
                     /score="116.0"
                     /tool="antismash"
                     /translation="MNQFQQELQSLNLNDYQSGNVVYWDQQQNQYPYYYIQDDGRRCGG
                     CGGCGGRCGGCAGRCGGCVGCAGCFSCFNCWNWW"
     CDS             5001..5246
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03601"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2450"
                     /sec_met_domain="TIGR03601 (E-value: 2.5e-45, bitscore:
                     151.1, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQFQQELQSLNLNDYQSGNVVYWDQQQNQYPYYYIQDDGRRCGG
                     CGGCGGRCGGCAGRCGGCVGCAGCFSCFNCWNWWII"
     CDS             5345..6361
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 69.6; E-value: 4.6e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2451"
                     /transl_table=11
                     /translation="LYTYDKLISWVESIKKKNDSSATALCIIKDNKIVLEHYSGYHSNT
                     STSKKVTASSQFNVASARKSYLGFMVAYALYDGKINSIDDEAIKYFKEFDPTLLDKTTI
                     RHLVTHSHGLGETDDGTIFREFEAGQDWAYRDINVRMMTQLIYRLYNKSFPELLKERVF
                     TPANFQETGWRIQQNENLVNVVNNPNEDAISEVGTVDDGTEKNLFVSAREFAYWGNLHL
                     NQGMINGKQVVPKEVIKIATSLQSPAYKNNELPQNGLFWFVQNEPKQLSELGERVPKGS
                     YQILGITGPTILVIPEYNVVVAKMYNKRYNYGGDNYLYYLREFSNLVADTFTSCNRA"
     PFAM_domain     5402..6292
                     /aSDomain="Beta-lactamase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00144.26"
                     /description="Beta-lactamase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2451_0182"
                     /evalue="1.50E-34"
                     /label="ctg1_2451"
                     /locus_tag="ctg1_2451"
                     /protein_end="316"
                     /protein_start="19"
                     /score="119.8"
                     /tool="antismash"
                     /translation="SSATALCIIKDNKIVLEHYSGYHSNTSTSKKVTASSQFNVASARK
                     SYLGFMVAYALYDGKINSIDDEAIKYFKEFDPTLLDKTTIRHLVTHSHGLGETDDGTIF
                     REFEAGQDWAYRDINVRMMTQLIYRLYNKSFPELLKERVFTPANFQETGWRIQQNENLV
                     NVVNNPNEDAISEVGTVDDGTEKNLFVSAREFAYWGNLHLNQGMINGKQVVPKEVIKIA
                     TSLQSPAYKNNELPQNGLFWFVQNEPKQLSELGERVPKGSYQILGITGPTILVIPEYNV
                     VVAKMYNKRYNYGGDN"
     CDS             6393..6536
                     /locus_tag="ctg1_2452"
                     /transl_table=11
                     /translation="LKDKVSKDKKQNIKDVNTEQNAIFSDPKDAANMQTVPQPKDFDEI
                     EY"
     CDS             6817..8025
                     /gene_functions="transport (smcogs) SMCOG1137:Major
                     facilitator superfamily MFS 1 (Score: 422.3; E-value:
                     2.6e-128)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2453"
                     /transl_table=11
                     /translation="MKQTSINPLLIVLGTIIVQIGLGTIYTWSLFNQPLVSKFGWNLNS
                     VAITFSITSFSLSFSTLFAAKLQRKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLA
                     GVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDSLGVS
                     QAFLYWGIIVLLLVLIGSFFLREAIVSNTVTETLHNDYTPREMMRTKQVYLLFFMLFTS
                     CMGGLYLIGMVKDIGVQLVGLSAATAANAVAMIAVFNTVGRIILGTLSDKIGRMKIVSA
                     TFIIIGVSVFTLSFIPLNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGI
                     VYQGFGFGALAGSFIGALLGGFQPTFITIGVLCTISFIISILIRPPNIEKKKEIKQLHR
                     KIA"
     PFAM_domain     6874..7758
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2453_0183"
                     /evalue="1.60E-22"
                     /label="ctg1_2453"
                     /locus_tag="ctg1_2453"
                     /protein_end="314"
                     /protein_start="19"
                     /score="80.1"
                     /tool="antismash"
                     /translation="IGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFA
                     AKLQRKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNL
                     IKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDSLGVSQAFLYWGIIVLLLVLIGSF
                     FLREAIVSNTVTETLHNDYTPREMMRTKQVYLLFFMLFTSCMGGLYLIGMVKDIGVQLV
                     GLSAATAANAVAMIAVFNTVGRIILGTLSDKIGRMKIVSATFIIIGVSVFTLSFIPLNY
                     GIYFACVASVAFCF"
     CDS             8159..8575
                     /locus_tag="ctg1_2454"
                     /transl_table=11
                     /translation="MKIVKQWVQEDSNYIREKVIEYNQKHLSNEEKAPSEKVSFIVKNE
                     KEEIVGGITAITFWHHVHVDFLWVSEECRHEGYGSKLIKLIEEFAIEKGCRLINLDTFS
                     FQAPDFYKKHGFKVIGVSEDHPKGHNHYYLEKRL"
     PFAM_domain     8234..8506
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2454_0184"
                     /evalue="7.00E-15"
                     /label="ctg1_2454"
                     /locus_tag="ctg1_2454"
                     /protein_end="116"
                     /protein_start="25"
                     /score="55.4"
                     /tool="antismash"
                     /translation="HLSNEEKAPSEKVSFIVKNEKEEIVGGITAITFWHHVHVDFLWVS
                     EECRHEGYGSKLIKLIEEFAIEKGCRLINLDTFSFQAPDFYKKHGF"
     CDS             8730..9173
                     /locus_tag="ctg1_2455"
                     /transl_table=11
                     /translation="MKKVNVTYALLYDKTNEKILMVKNKGKNGSYYTLPGGAVKFGETL
                     EEAVIREVKEETGLHITVKGICSISEAFFEERGHHAIFFNFLGEIIGGETYISRPKEIE
                     EITWMELHIAAPYLRIPEQLLDFLQRKEIVPYFFNGTIVHQSL"
     PFAM_domain     8748..9071
                     /aSDomain="NUDIX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00293.30"
                     /description="NUDIX domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2455_0185"
                     /evalue="7.80E-15"
                     /label="ctg1_2455"
                     /locus_tag="ctg1_2455"
                     /protein_end="114"
                     /protein_start="6"
                     /score="55.2"
                     /tool="antismash"
                     /translation="TYALLYDKTNEKILMVKNKGKNGSYYTLPGGAVKFGETLEEAVIR
                     EVKEETGLHITVKGICSISEAFFEERGHHAIFFNFLGEIIGGETYISRPKEIEEITWME
                     LHIA"
ORIGIN
        1 acttccgatt ggccattctc cgttttcaat tttttctttc atacagtcta ttatctgccg
       61 atatttgggc acctttttat cgattgtcat ataaaaaact ccctcgttta tttaaaaatg
      121 aaaagtggtt ggttttttcg ataaataact ggttgaagac attgtatcaa ctattaaata
      181 tgatgaaaag aaataattgg caatttgaaa atggttggtt tattggagag gaagagaaaa
      241 catgcttaat aaaaaatggg atttacaaat catatgtgct cacgctttta cgattctaat
      301 atggggaact gcatttccgg caattcgtat ggggcttgaa tcatacacac ctgaacatct
      361 tactttacta cgcttgttaa tcgcttcatt catacttctt gtgttttcct ttatatacaa
      421 actgcgatta cctgatttga aagacattcc agcgattttt atattcggtg ctttagggtt
      481 tactatttat cacattgcat taaactacgg cgaaaaaaca gtaaatgctg gatctgcaag
      541 tttaataatt tcagtcactc caatagtgac ggcaattctt gcttctgttt ttttgaatga
      601 aaaaatgaaa ttaaatggct ggatcggtgg tgtaattagt tttattggaa ttgctctcat
      661 atcatttagt caaggaggtt ctattcaatt taatagtgga ggattattta tattattagc
      721 agccgtttca gaaagcctat ttttcgtttt ccaaacttct tacttgaaaa agtacggctt
      781 tttgctattt accatatata caattttatc tagcactgta tgtatgctta ttttcttacc
      841 gggaatttat acagaaatac tagcagctcc tcttgaagtg aatgtgagtg ttatatattt
      901 aggcttattt ccaacagtac tcccgtatct tgccttagcg tatatcatat ctcgtgctgg
      961 tgcttccgag gcaacaagtt ctctatattt aacgccagtc actgcgtgct ttatagcttg
     1021 ggtatggtta ggtgaagtac cgacttttat ttctgtaatt ggagatggga ttactatact
     1081 tgggatattg attgctcata tacgagtagt aagtaaagaa aaacatagga atctagtaaa
     1141 caataaatcg atataactta attaaacaat gattttatga tactttttga tatagtttct
     1201 ttcttatgtt gataaatata atattttgta tttcagttaa atattgtatg ttacatttta
     1261 tgtagtaaac attttaaaag gagatgacaa cataatgaat agaaaaagaa atatttttac
     1321 atgcctttct attataggta tcggattagc tagtgtttct aattctagtt ttgcagcaaa
     1381 tgtaacggat agttcagtac aacattctat ccctgtcatg aatcaacaag tagctgttgc
     1441 aaaagaaatg aaaccatttc ctcagcaagt taattatgca ggtgttataa aaccgaatca
     1501 tgttacacag gaaagcttaa atgcttctgt aataagttac tacgataatt ggaaaaagaa
     1561 atatttgaaa aatgatttat cttctttacc tggtggttat tatgtaaaag gagagattac
     1621 gggtgatgcc gatgggttta agccacttgg aacttcagag ggacaagggt atgggatggt
     1681 aattacagta ttaatggctg gttatgattc gaatgcccaa aaaatctatg acggtttatt
     1741 taaaacagca agaactttta aaagctctca aaatcctaat ttaatggggt gggttgtagc
     1801 agataataaa aaagcacaag gacattttga ttctgctact gatggagatt tagatattgc
     1861 atattcactt ctccttgctc ataagcagtg gggatcaaat ggatcagtta attatttgaa
     1921 agaagcacaa aacatgatta caaaaggtat taaagctagt aatgttacga ataataaccg
     1981 actaaattta ggagattggg attctaaaag ttcacttgat acaaggccat ctgattggat
     2041 gatgtcacac attagagcat tttatgaatt tacaggtgat aaaacttggc ttactgttat
     2101 taatactttg tacgatgtat atacgcaatt taataataag tactctccaa atacaggact
     2161 tatttcagat tttgttgtaa aaaatccacc acaacccgca cctaaagatt tcttagatga
     2221 gtcaaaatat acaaattcat attattacaa tgctagtcgg gtaccattaa gaattgtaat
     2281 ggattatgcg atgtacggcg agaaaagaag taaagtcatc tctgataaag tctcttcatg
     2341 gattcaaaat aagacgaatg gaaatccttc taaaattgtg gatggctatc aattaaacgg
     2401 atcaaatatt ggtagttatt caactgctgt attcgtttca ccatttattg ctgcaagtat
     2461 aacgagtaat aataatcaaa agtgggtaaa tagtggttgg gattggatga agaataagcg
     2521 agaaagctat tttagtgata gttataattt attaacgatg ctatttatta cgggaaattg
     2581 gtggaagcct gtacctgatg ataaagaaat acaaaatcta ataaatgatg aaatgtatga
     2641 aggatatgat aaataataga atttgataat ggttagctgg gagaaggaat tagcatgcgc
     2701 tagttccttt ttaatatccc gtaacacatt atccattcta aaatttgcat agatatactt
     2761 gcatttttca tatacataac tattgtttgc tttatttttt tatggaagga gagtatttct
     2821 tggaaaaagt attatttttt ggagatccag gaattgatga ctcatttgcc attatgtatg
     2881 gtttactgca tcccgaaatt gaaattgtcg gtattgtaac tggatatgga aatgttgagc
     2941 atatacatgc tgcacataat gcggcgtata ttttacagtt agcaaatagg caagacattc
     3001 ctgtcattag cggcgcaaca aaaccactta ctgaagaaat ttcaacgtac tatcctgaaa
     3061 ttcatggatt agaaggatta gggcccatac atgttccaga aagcgtatta tctattccga
     3121 tatataattt tggtagtatt gctgcaattc ttgtaaagta tggaaaagat ttaacaattg
     3181 ttgatgtagg aagatctact tcattagcga ttgcttttaa tttatggaat gacttaatac
     3241 taaatgtaaa aggaatatat ttcatgggtg gtgtcttttt agaagtagga aacgttactc
     3301 cattagcaga ggcaaatgtg tatggagatc ctatagcaag taaaattgtt tttcagcaag
     3361 caaagaattt attcatattc cctttaaatg taacaaataa agctgtgtta actccaaatg
     3421 tatttaatta tatccaagct aattcaaaga atccatttca tacgataatg aaaccgatgt
     3481 atgattacta tttatctgca taccaaaaac ttaatccatc tatcgaaggg cctttgctac
     3541 atgatgtggt tgctataagt ggattagtta acccaagttt ttttgaattt gcgcatcgta
     3601 cagtgaatgt agatacatac ggagatacga aaggacaaac atttgctgat tttcgcccta
     3661 actctaaatc tgaaggagcc cgtatagctt tagaaataga tgcagaaaaa ttcattcaag
     3721 attttataaa aatcatgtta taagctgttg tcgaaaaagg gaattatttc actacgttga
     3781 atataaaaat atatcctctt tataaaggag cttacaatat tgaatgtcca gttaaaggtt
     3841 gttacgagag agaattggga agatgcatta aagttacaag ttaaagaaaa tcagttgaaa
     3901 tttgttccat ccgtagcagt ttcgcttgct aaagtatata taaaaccaga tggtgacaat
     3961 gtagaataca taccatttgc tatatacgat ggtgacctta tggttggttt tgttatgcat
     4021 gctgttgtaa tagagtcatc ggatatgtat tggattaacg gatttattat tgatcaatcg
     4081 cagcaaggta atggttatgg aaaagcggca ttacaagaaa gtatttattt aataaaaaat
     4141 acgtttaagg cgtgtaaaga aataagatta acagtacata aagataatat atgtgcaaag
     4201 aaattatatg aaaattacgg ttttcaacca ttgggacatg attatgatgg cgaggaagta
     4261 tatcgtgtat ttgtttaact tttattaagt attggcgtga aatgaaaatg actactttaa
     4321 tcaagggaat agcgaatgac taggaggaat atcaattgaa aagtaaattc catcatattg
     4381 tacgagcagt cgtgataaaa gatgagaaat tattggttgc tgaatatatt gggcatcatt
     4441 attttttacc aggtggccat gttgaaatcg gggaatcagc agagcatgca ttaataagag
     4501 agctacgaga agaacttgga gtaaactgca gtataaaaca atttttagga gttatagaaa
     4561 accgatggca agataaagga atgcttcatc atgaaatcaa ccacattttt gaagtatctt
     4621 caaaagagtt gtatattgat ttatcaccaa agtctagaga atctcattta gcatttcatt
     4681 ggatagatta tagtaaagaa tctttaaaaa cttataaaat catgccaatg ccctccgtta
     4741 aagaattact agaaagaaaa ttaagtgatg aactactaaa ttgttggata agtaattttt
     4801 aaatcactct attttatagt aaatacgtcc atcgaaagga tataaagaaa ataggctaaa
     4861 aaacaaggta catcacctag tgtaagttca tattttgttg atgtacgtat ttagtctgta
     4921 gctttgtttc tatttggttt acaaaaatat ataaactttt tacatttggg cggaattact
     4981 tataaatgga ggggttcgta atgaatcagt ttcaacaaga actacaatca ttaaacctta
     5041 atgattatca atctggtaat gtagtttatt gggatcaaca acaaaatcaa tatccatact
     5101 attatattca agacgatgga cgtcgttgcg gtggctgcgg aggttgtggt ggacgctgcg
     5161 gtggttgtgc aggacgttgc ggcggatgtg taggttgcgc aggatgtttc agctgcttta
     5221 attgctggaa ctggtggatt atttaagtat agaaaatcaa taatatttca catgaaagaa
     5281 aggtgtttat agtaatactt ttctttcatg ttgtgatttt ttatgagtat taagggggat
     5341 ttatttgtat acatacgata agttgatttc ttgggtagag agtataaaaa agaaaaacga
     5401 tagttctgct acagcgctat gtattataaa ggataacaaa attgtactag agcattatag
     5461 tggatatcat tcaaatacat ctactagtaa aaaagtaaca gcatcttcac agttcaacgt
     5521 cgcttctgcg agaaaaagtt atttaggatt catggtagcg tatgcgcttt atgatgggaa
     5581 aataaactct attgatgatg aagcgataaa gtattttaaa gaatttgatc ctacattact
     5641 tgataaaaca acgattagac atttagtaac tcattcacac ggtctaggag aaacggatga
     5701 cgggacaatt ttccgtgaat ttgaagctgg acaagattgg gcgtatagag atattaatgt
     5761 aagaatgatg acgcagctca tttatcggct ttataataaa agttttcctg aattgttaaa
     5821 ggagcgtgta tttactcctg ctaatttcca agaaacagga tggagaatac agcaaaatga
     5881 aaatttagtt aacgttgtta ataatccaaa tgaagacgcg atcagtgagg tcggtacagt
     5941 agatgacggt accgaaaaaa atctgtttgt ctcagctaga gagtttgctt attggggcaa
     6001 ccttcattta aatcaaggca tgataaatgg taaacaagtt gttccaaaag aagttataaa
     6061 aattgctact agcttgcaga gtccagctta taaaaataat gaactaccac aaaacgggtt
     6121 gttttggttc gttcaaaatg aaccaaaaca attaagtgaa cttggtgaac gtgttccaaa
     6181 aggttcgtat caaatattag gaattactgg accaaccatt ttagtaatac ctgagtataa
     6241 tgtagttgtt gcgaaaatgt acaataaaag atataactac ggcggtgata attacttata
     6301 ttatttacgt gaatttagca atttagtcgc cgatacattt actagctgta atagggcata
     6361 attactccta taacaaaaag gagggaaaga atttgaaaga taaagtgagt aaagataaaa
     6421 agcaaaatat taaagatgta aatacagagc aaaatgcaat ttttagcgat ccgaaagatg
     6481 cagctaacat gcaaactgta ccgcagccga aagattttga tgaaatcgaa tattaatttc
     6541 tcatccgact atatgacgaa taaaaaatac gtcttaagtc ccatcacatg taagaaaata
     6601 tttgataaca tatatacata agcacttgaa aatggcttat cttaacaaag ctttctttaa
     6661 atgtatctga tataacctgc gaaaagacac ttcattatga agtgtctttt tgtgtacata
     6721 aacttaattt ccattttccg tacagtatct tgtatttttc aatggatata ctaactgtga
     6781 aaattcatgt caagataaaa gaaggggaca gttagtatga aacaaacttc tataaatccg
     6841 ctattaattg ttttaggtac aatcattgtt caaattggcc ttggaacaat ttatacatgg
     6901 agtttattta atcaacccct tgtaagtaag ttcggatgga atctcaattc agttgcgata
     6961 actttctcca taacaagctt ttctttatca ttttcaacct tgtttgcagc aaagttgcag
     7021 cgaaaattag gacttcgtaa acttatcgct actgcaggaa ttgttctagg actcggttta
     7081 atacttagtt cacaagtttc ttccttacca ttactatatt tattagctgg tgttgttgtt
     7141 ggatatgcgg atggaacagc ttatattacg tcactatcta atttaattaa atggtttcca
     7201 aatcgaaaag gacttatttc tggaatatct gtttcagcat atggaatggg cagtttaatt
     7261 tttagatata taaacggaaa tcttatcgat agccttggtg tatcacaagc atttttatat
     7321 tggggcatta tcgtcttact tttagtatta atcggatcgt tcttcttacg tgaagcgatt
     7381 gtaagtaata cggtaacaga aacattacac aatgactata cgccacgtga aatgatgaga
     7441 acgaaacaag tatatctgtt gtttttcatg ttattcacat cgtgtatggg tggtctgtac
     7501 ttaattggta tggtaaaaga tatcggagta caactcgttg gacttagtgc agcaaccgcc
     7561 gctaacgccg tcgcaatgat tgcagtcttt aatacagtag gtagaatcat tcttggaacg
     7621 ttatcagata aaattggtag aatgaaaatt gtctctgcaa catttattat tattggagtg
     7681 tccgtcttta ctcttagttt cattccatta aattacggga tttattttgc ttgtgtagca
     7741 agtgtcgcct tttgcttcgg cggtaatatt acaatattcc cagctattgt cggagatttc
     7801 ttcggtttaa aaaatcatag tacaaattac gggattgtat atcaaggttt cggatttggt
     7861 gcacttgcag gttcattcat tggagcatta cttggtggat ttcaaccaac ctttattaca
     7921 ataggtgttt tatgtacgat ttctttcatt atttctatat taattcgtcc accaaatata
     7981 gagaagaaaa aagaaatcaa gcagttacat cgaaaaatag cttagtttta aaaagagtcc
     8041 ttatgctagg gctctttttc attacaacgt taactatgct cctttcattg tttagtaaag
     8101 acaggacaat acaattatga aatggaatag ataaaataaa aggagcgtga tatgtaaaat
     8161 gaagatagta aaacaatggg ttcaagaaga tagtaattac atacgagaaa aagtaattga
     8221 atataatcaa aagcatcttt caaatgaaga gaaagctcct tcagaaaagg ttagttttat
     8281 agtgaaaaat gaaaaagagg aaatagtagg agggataaca gctataacat tttggcacca
     8341 tgtacatgtt gattttctat gggtttctga agaatgcaga cacgaaggat acggaagtaa
     8401 attaataaaa cttatcgaag aatttgcaat tgaaaaagga tgtaggctaa tcaacttaga
     8461 tacgtttagc tttcaagctc cggattttta taaaaaacat ggatttaaag taattggagt
     8521 gagtgaagat catccaaaag gacataatca ttattattta gagaaaaggt tataaagtgt
     8581 atggaattaa ttaatctcaa tatataaaat ttaatgaatt gaaaagaacg tattttgaat
     8641 catctatatc aaaatacgtt ctttttaatt tgtatgtatc tggtaaaatg aaatagagac
     8701 agaaaattct tattaataaa ggggtaaata tgaaaaaggt taatgttaca tacgcgcttt
     8761 tgtacgataa aacgaacgaa aaaatcttaa tggtaaaaaa caaagggaaa aatggatctt
     8821 attacacatt accaggtggc gcagttaaat ttggggaaac gttagaagag gcagtcattc
     8881 gggaagtaaa agaagaaaca gggctacata taactgtaaa ggggatttgt tccataagcg
     8941 aagccttttt cgaggagaga ggccatcatg ccattttctt taatttttta ggtgaaataa
     9001 tcggcggaga gacatatata tcccgtccaa aagaaatcga agagattact tggatggaat
     9061 tacatatagc agcaccgtat ttacgtatac ctgaacagtt actagatttt ttacaaagga
     9121 aagaaatagt accttacttt tttaacggaa caatcgttca tcaatcttta taaataaatt
     9181 atttcattta aggcggggaa aaacatggag tttatcgtta atcacaaaca tatcactcaa
     9241 gtactttcag aagtaagtaa agctatatct acaaaagttc taattcctat attatctggt
     9301 atcaaaataa cagccgatca atctggaatt actttaatcg caagtaactc gaatgttttt
     9361 attaaaaaat ttatacctaa ttcaatcgaa gacgaacaga ttgcaactat attacaagca
     9421 ggaactattg ttgtacctgc aaaatatttc attgaaatta taaagaaaat gccaagtgat
     9481 atagtaataa aaagtaagaa tgaacaaatc attacgatac aatcagaaga aatcacatta
     9541 aacttaaatg gacttccagc aaatgagttt ccgaatgtac cacttataga ggatcatgca
     9601 gaaatacaag tagaaacaga acaattgatt gaagtgttta aacaaactgt ctttgcagta
     9661 gctaaaaacg aatccagacc tgttctcacc ggagtacata tagagttaga tcataataag
     9721 ttagtttgcg ctgctactga ctcgcataga ctagctatac gtgaaacgct aatttcttca
     9781 gatgcgaaag caaattgtat cgtaccaagc gcaaccatta gtgaacttct aaaattaatg
     9841 aacagtcata cggaattcgt atacatatac ctttcagaca gtcacgttat ttttacattc
     9901 ggaacaacta cgttatattc aagactcatt gaagggaaat atcctaatat atctaatctc
     9961 attccaaatg aatttcaaac ggttattaac gtagaaagaa aaaagatttt acaaggtgta
    10021 gatcgatcga gcttattagc aagtgaatgg gcaaataaca acgtcaactt agaaatcata
    10081 aacgaatcca caattaaaat ttcttctaac gcttctcaga ttggtaaaat agctgaaaca
    10141 caacaagtag atgcgattca aggtgaaaaa caattaaata tatctttcga cggacgattt
    10201 atggtagatg ctttaagggc aataacagaa gaaatggtta ctttaa
//
