LOCUS       NZ_CP064875.1           9029 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP064875.1 Bacillus toyonensis strain P18 chromosome, complete
            genome.
ACCESSION   NZ_CP064875
VERSION     NZ_CP064875.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:56:40
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2491900
            Orig. end    :: 2500929
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1449
                     /NRPS_PKS="Domain: Aminotran_1_2 (145-465). E-value:
                     1.6e-29. Score: 95.0. Matches aSDomain:
                     nrpspksdomains_ctg1_2375_Aminotran_1_2.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 320.9; E-value: 2e-97)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2375"
                     /transl_table=11
                     /translation="LFKDFKVVKDRPVYIQLKDYFKKMIMKGHLLGDQKIPSTRELSEL
                     LSVSRNTVLSAYADLEQEGLIYAVKGKGNFVAKVDISNTSSVEIDWKNKLNTVTTLADE
                     LDLMKHGVRWEKGMVVFNSIAPDEKLFDVENFKRAFLTRMSIEGDIVLNYGYAKGYRPL
                     MKYLLHYMEMKGVDISNKDILITNGFTEGLDIVLSSLAKKSGRVICENPTHHAALKLFR
                     LHGLEVHGIDMNDDGIDTTEVEKSLREKDFDFAYLIPSYHNPTGIVTSSEKRTELMRLF
                     SKYKVPIIEDGFNEELRYSGSHLSPLLTFAGAGNNVIYISSFSKVLFPGLRVGWIIADK
                     ELIHYLESVKRARTIHTSTLDQAVLFQYLHEGYFEKYLKKARSVYKKKYELAVGACNQY
                     IPFKRMTGDGGLHLFIELEEKIHARTLLQKCYEKGVTFSPGDVFYSDGGGANTFRLGFS
                     RLKEKEIVSGIQIIGETLKNETWS"
     protocluster    1..9029
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2495914:2496274](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4015..4374
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..9029
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9029
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     46..228
                     /aSDomain="GntR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00392.23"
                     /description="Bacterial regulatory proteins, gntR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2375_0170"
                     /evalue="2.70E-12"
                     /label="ctg1_2375"
                     /locus_tag="ctg1_2375"
                     /protein_end="76"
                     /protein_start="15"
                     /score="46.3"
                     /tool="antismash"
                     /translation="QLKDYFKKMIMKGHLLGDQKIPSTRELSELLSVSRNTVLSAYADL
                     EQEGLIYAVKGKGNFV"
     aSDomain        436..1395
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_2375_Aminotran_1_2.1"
                     /evalue="1.60E-29"
                     /label="ctg1_2375_Aminotran_1_2.1"
                     /locus_tag="ctg1_2375"
                     /protein_end="465"
                     /protein_start="145"
                     /score="95.0"
                     /tool="antismash"
                     /translation="IEGDIVLNYGYAKGYRPLMKYLLHYMEMKGVDISNKDILITNGFT
                     EGLDIVLSSLAKKSGRVICENPTHHAALKLFRLHGLEVHGIDMNDDGIDTTEVEKSLRE
                     KDFDFAYLIPSYHNPTGIVTSSEKRTELMRLFSKYKVPIIEDGFNEELRYSGSHLSPLL
                     TFAGAGNNVIYISSFSKVLFPGLRVGWIIADKELIHYLESVKRARTIHTSTLDQAVLFQ
                     YLHEGYFEKYLKKARSVYKKKYELAVGACNQYIPFKRMTGDGGLHLFIELEEKIHARTL
                     LQKCYEKGVTFSPGDVFYSDGGGANTFRLGFSRLKEKEI"
     PFAM_domain     436..1395
                     /aSDomain="Aminotran_1_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00155.23"
                     /description="Aminotransferase class I and II"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2375_0171"
                     /evalue="6.00E-27"
                     /label="ctg1_2375"
                     /locus_tag="ctg1_2375"
                     /protein_end="465"
                     /protein_start="145"
                     /score="94.9"
                     /tool="antismash"
                     /translation="IEGDIVLNYGYAKGYRPLMKYLLHYMEMKGVDISNKDILITNGFT
                     EGLDIVLSSLAKKSGRVICENPTHHAALKLFRLHGLEVHGIDMNDDGIDTTEVEKSLRE
                     KDFDFAYLIPSYHNPTGIVTSSEKRTELMRLFSKYKVPIIEDGFNEELRYSGSHLSPLL
                     TFAGAGNNVIYISSFSKVLFPGLRVGWIIADKELIHYLESVKRARTIHTSTLDQAVLFQ
                     YLHEGYFEKYLKKARSVYKKKYELAVGACNQYIPFKRMTGDGGLHLFIELEEKIHARTL
                     LQKCYEKGVTFSPGDVFYSDGGGANTFRLGFSRLKEKEI"
     CDS             1454..2368
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2376"
                     /sec_met_domain="RimK (E-value: 3.5e-08, bitscore: 31.5,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 6.8e-06, bitscore:
                     24.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGVIMGGVSSEKQVSIMTGNEMIAHLDKNKYEIVPITLNEKMD
                     LIEKAKDIDFALLALHGKYGEDGTVQGTLESLGIPYSGSNMLSSGICMDKNISKKILRY
                     EGVETPDWIELTKMADLKLDDLDKLGFPLVVKPNSGGSSVGVKIVNDKNELISMLETVF
                     EWDSEVVIEKYIKGDEITCSIFDGKQLPIVSIRHAAEFFDYNAKYDDVSTIEEVIELPT
                     EIKERVNKASLACYKALKCSVYARVDMMVKDGIPYVMEVNTLPGMTQSSLLPKSADAAG
                     INYSKLLDMIIETSLRVRKEEGF"
     PFAM_domain     1457..1705
                     /aSDomain="Dala_Dala_lig_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01820.23"
                     /description="D-ala D-ala ligase N-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2376_0172"
                     /evalue="4.20E-21"
                     /label="ctg1_2376"
                     /locus_tag="ctg1_2376"
                     /protein_end="84"
                     /protein_start="1"
                     /score="75.5"
                     /tool="antismash"
                     /translation="RIGVIMGGVSSEKQVSIMTGNEMIAHLDKNKYEIVPITLNEKMDL
                     IEKAKDIDFALLALHGKYGEDGTVQGTLESLGIPYSGS"
     aSDomain        1457..2338
                     /aSDomain="TIGR01205"
                     /aSTool="tigrfam"
                     /description="D_ala_D_alaTIGR: D-alanine--D-alanine ligase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2376_0032"
                     /evalue="1.60E-87"
                     /identifier="TIGR01205"
                     /label="ctg1_2376"
                     /locus_tag="ctg1_2376"
                     /protein_end="295"
                     /protein_start="1"
                     /score="291.4"
                     /tool="antismash"
                     /translation="RIGVIMGGVSSEKQVSIMTGNEMIAHLDKNKYEIVPITLNEKMDL
                     IEKAKDIDFALLALHGKYGEDGTVQGTLESLGIPYSGSNMLSSGICMDKNISKKILRYE
                     GVETPDWIELTKMADLKLDDLDKLGFPLVVKPNSGGSSVGVKIVNDKNELISMLETVFE
                     WDSEVVIEKYIKGDEITCSIFDGKQLPIVSIRHAAEFFDYNAKYDDVSTIEEVIELPTE
                     IKERVNKASLACYKALKCSVYARVDMMVKDGIPYVMEVNTLPGMTQSSLLPKSADAAGI
                     NYSKLLDMIIETS"
     PFAM_domain     1760..2332
                     /aSDomain="Dala_Dala_lig_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07478.15"
                     /description="D-ala D-ala ligase C-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2376_0173"
                     /evalue="1.10E-50"
                     /label="ctg1_2376"
                     /locus_tag="ctg1_2376"
                     /protein_end="293"
                     /protein_start="102"
                     /score="172.0"
                     /tool="antismash"
                     /translation="RYEGVETPDWIELTKMADLKLDDLDKLGFPLVVKPNSGGSSVGVK
                     IVNDKNELISMLETVFEWDSEVVIEKYIKGDEITCSIFDGKQLPIVSIRHAAEFFDYNA
                     KYDDVSTIEEVIELPTEIKERVNKASLACYKALKCSVYARVDMMVKDGIPYVMEVNTLP
                     GMTQSSLLPKSADAAGINYSKLLDMIIE"
     CDS             2675..3364
                     /locus_tag="ctg1_2377"
                     /transl_table=11
                     /translation="MTFSQTLRKEVDSIWEASFHHPFVKKLGEGTLDLASFRYYVLQDS
                     YYLSHFARVQTLGAAKALELETTARMAHHAQNTYEAELSLHENFAKKLGITEEEKGHFI
                     PAPTAYAYTSHMYRAAYEGHLGDIIAAILPCYWLYYEIGERLKECQPEEPIYKEWISAY
                     GSDWFRTLVEEQITRLDTIAEQVTESDQKRMKQHFIISSQYEYSFWEMAYTLEKWPVDT
                     EVKDVIG"
     PFAM_domain     2699..3316
                     /aSDomain="TENA_THI-4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03070.18"
                     /description="TENA/THI-4/PQQC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2377_0174"
                     /evalue="4.40E-57"
                     /label="ctg1_2377"
                     /locus_tag="ctg1_2377"
                     /protein_end="214"
                     /protein_start="8"
                     /score="193.4"
                     /tool="antismash"
                     /translation="KEVDSIWEASFHHPFVKKLGEGTLDLASFRYYVLQDSYYLSHFAR
                     VQTLGAAKALELETTARMAHHAQNTYEAELSLHENFAKKLGITEEEKGHFIPAPTAYAY
                     TSHMYRAAYEGHLGDIIAAILPCYWLYYEIGERLKECQPEEPIYKEWISAYGSDWFRTL
                     VEEQITRLDTIAEQVTESDQKRMKQHFIISSQYEYSFWEMAYT"
     aSDomain        2705..3316
                     /aSDomain="TIGR04306"
                     /aSTool="tigrfam"
                     /description="salvage_TenA: thiaminase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2377_0033"
                     /evalue="9.20E-75"
                     /identifier="TIGR04306"
                     /label="ctg1_2377"
                     /locus_tag="ctg1_2377"
                     /protein_end="214"
                     /protein_start="10"
                     /score="248.8"
                     /tool="antismash"
                     /translation="VDSIWEASFHHPFVKKLGEGTLDLASFRYYVLQDSYYLSHFARVQ
                     TLGAAKALELETTARMAHHAQNTYEAELSLHENFAKKLGITEEEKGHFIPAPTAYAYTS
                     HMYRAAYEGHLGDIIAAILPCYWLYYEIGERLKECQPEEPIYKEWISAYGSDWFRTLVE
                     EQITRLDTIAEQVTESDQKRMKQHFIISSQYEYSFWEMAYT"
     aSDomain        4015..4317
                     /aSDomain="TIGR03601"
                     /aSTool="tigrfam"
                     /description="B_an_ocin: bacteriocin,
                     heterocycloanthracin/sonorensin family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2378_0034"
                     /evalue="1.40E-27"
                     /identifier="TIGR03601"
                     /label="ctg1_2378"
                     /locus_tag="ctg1_2378"
                     /protein_end="101"
                     /protein_start="0"
                     /score="94.1"
                     /tool="antismash"
                     /translation="MNKFQQELQALSLNDYQSGNIVYWDQQNQYPYYYFEDAARRCGGC
                     GRCGGCGRCGGCGGRCGGGGFRCGGFRCIGCFGCFGCGGCGGCGSCGGCGGCSNCF"
     CDS             4015..4374
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03601"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2378"
                     /sec_met_domain="TIGR03601 (E-value: 1e-32, bitscore:
                     110.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKFQQELQALSLNDYQSGNIVYWDQQNQYPYYYFEDAARRCGGC
                     GRCGGCGRCGGCGGRCGGGGFRCGGFRCIGCFGCFGCGGCGGCGSCGGCGGCSNCFNGF
                     NGTTDTTGTIVTYEY"
     CDS             complement(5240..5587)
                     /locus_tag="ctg1_2379"
                     /transl_table=11
                     /translation="LDEFLSSAALNQNSIGPTLPPMQPFQSPTRPTGNTGPPGIVSVTF
                     NQSHIPATSPTNLVLPAISVGVNQIVKLEGVFKSDYVSLSPLTEFTVSSILALKRGVFT
                     IAVQMELQEDI"
     aSDomain        complement(5510..5551)
                     /aSDomain="TIGR03720"
                     /aSTool="tigrfam"
                     /description="exospor_lead: exosporium leader peptide"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2379_0035"
                     /evalue="4.10E-07"
                     /identifier="TIGR03720"
                     /label="ctg1_2379"
                     /locus_tag="ctg1_2379"
                     /protein_end="26"
                     /protein_start="12"
                     /score="27.8"
                     /tool="antismash"
                     /translation="NSIGPTLPPMQPFQ"
     CDS             complement(6695..6994)
                     /locus_tag="ctg1_2380"
                     /transl_table=11
                     /translation="MPVFINYAITPKVFNPNLTSLPNNRRSFIPTQKESSKNICYLLET
                     YYLGKKIKQLLVNGTILKASIFVGFHNRSRLATFIDENGDITVVNCERIDAILL"
     CDS             complement(7075..7296)
                     /locus_tag="ctg1_2381"
                     /transl_table=11
                     /translation="MAEHTKCVCEQLERLQLGTEVDVFLTGTTLEDLIFTNFNPDNFCV
                     TFVDNTTEPGSIIVLDCRDIQALRIEAE"
     CDS             7785..8585
                     /locus_tag="ctg1_2382"
                     /transl_table=11
                     /translation="MSSNESNFSFTSNKDIVKYLNVRKDPVDLRDKIFRSYLFSNEADL
                     PTQVDLRPKMSGIVNQWNIGSCTANAIVSGLREYLLLQSGRPFTCLSRLFLYYHEREIE
                     GHIQEDSGANVRDGMDVLKKIGVCPEEDFPYTENFRDKPSPKAESDATLYKIGTYHRIQ
                     DLSGLKAALAHGLVVVLGFAVPKSFMSEEVKKTGIVPVSGTDDVIVEDGQQAGHAVCAA
                     GYDDNKKTVIIRNSWGEEWGDKGYCYFPYELFENGIVQDMWTGR"
     PFAM_domain     7917..8531
                     /aSDomain="Peptidase_C1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00112.25"
                     /description="Papain family cysteine protease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2382_0175"
                     /evalue="7.80E-16"
                     /label="ctg1_2382"
                     /locus_tag="ctg1_2382"
                     /protein_end="249"
                     /protein_start="44"
                     /score="58.9"
                     /tool="antismash"
                     /translation="LPTQVDLRPKMSGIVNQWNIGSCTANAIVSGLREYLLLQSGRPFT
                     CLSRLFLYYHEREIEGHIQEDSGANVRDGMDVLKKIGVCPEEDFPYTENFRDKPSPKAE
                     SDATLYKIGTYHRIQDLSGLKAALAHGLVVVLGFAVPKSFMSEEVKKTGIVPVSGTDDV
                     IVEDGQQAGHAVCAAGYDDNKKTVIIRNSWGEEWGDKGYCYF"
     CDS             8868..9029
                     /locus_tag="ctg1_2383"
                     /transl_table=11
                     /translation="MKVLKNQLREWKNQSKKKNKKKRKEKFSTREIEDLMGVHRPCYER
                     RRGALRQK"
ORIGIN
        1 ttgtttaaag attttaaagt tgtaaaagat cgtcccgttt atattcaatt aaaggattat
       61 tttaaaaaga tgattatgaa agggcatttg ctcggtgatc aaaagatccc atcaacaagg
      121 gaactgagtg aattattatc agtgagcaga aatacagtac tctctgctta tgcggattta
      181 gaacaagaag gactcattta tgcagtaaaa ggaaaaggga atttcgttgc gaaggtggat
      241 atatctaaca cctcgtctgt tgaaatagat tggaaaaata aactgaatac agttaccaca
      301 ttagcggatg aattagactt aatgaagcat ggagttcgct gggaaaaagg aatggttgtt
      361 tttaatagta tagccccgga cgaaaagcta tttgatgttg aaaatttcaa aagagctttt
      421 cttactcgta tgtccattga aggggatatc gtattgaact acggatatgc aaaaggttac
      481 cgaccgttaa tgaaatatct acttcattac atggaaatga aaggtgtaga tatttcgaac
      541 aaagatattt taattacaaa tggatttaca gaaggattag atattgtact atcttcctta
      601 gcgaaaaaat cagggcgtgt gatttgtgag aatccaactc accatgctgc attgaaactt
      661 tttcgtttac atggacttga agttcatggg atagatatga atgatgatgg tattgatacg
      721 actgaagtag aaaaaagttt acgtgaaaag gattttgatt ttgcgtattt aattccttct
      781 tatcataatc caactggtat tgttacaagt tcggagaaaa gaacggaatt gatgcggtta
      841 ttttcgaaat ataaggttcc tattatagag gacggattta atgaagaatt acgttattca
      901 ggttcacatt tatcgccatt attaactttt gctggggctg gtaataatgt gatttatatt
      961 agtagctttt cgaaggtact tttccctggt ttacgtgtag ggtggattat tgccgataaa
     1021 gaactgattc attatttaga aagtgttaaa agagcacgaa ccattcacac atctacgtta
     1081 gatcaagctg ttctgtttca atatttacat gaaggatatt ttgaaaaata tttgaaaaag
     1141 gcaagatctg tttacaagaa aaaatatgag ttagccgttg gggcttgcaa tcagtacatt
     1201 ccgtttaaaa ggatgactgg agatggcgga cttcatttgt ttatagagtt ggaagagaaa
     1261 attcacgctc gcacactttt acaaaagtgt tatgagaaag gtgtaacgtt ttctcctgga
     1321 gatgtttttt attctgatgg agggggagcg aatacattcc gcttaggttt ttcacgtttg
     1381 aaggagaagg aaatagttag tgggattcaa ataattggtg aaactttaaa aaatgaaact
     1441 tggagttgag aaaatgagaa ttggcgttat tatgggagga gtatcctctg aaaaacaagt
     1501 atcaattatg actggaaatg aaatgattgc acatttagat aaaaataagt atgaaatcgt
     1561 tccaattacg ttaaatgaaa aaatggattt aattgaaaaa gcgaaagaca ttgattttgc
     1621 attgctagca ttacacggaa aatacggaga agatggtacg gttcaaggga cgcttgagag
     1681 tttaggtatt ccatatagcg gcagcaatat gttatctagc ggtatatgta tggataaaaa
     1741 tatttcgaaa aagattttgc gttatgaagg agtagaaaca ccagattgga ttgaacttac
     1801 aaaaatggcg gatctaaagc ttgatgattt agataagtta ggatttccgt tagtggtaaa
     1861 accaaactct ggcggctcca gtgttggcgt aaagatcgtc aatgataaaa atgaattgat
     1921 ctcaatgctg gaaactgtat tcgaatggga ttctgaagta gtaattgaga agtatataaa
     1981 gggtgacgag attacatgtt caatttttga tggtaaacag ttacctatcg tttcaattcg
     2041 acatgcagct gagtttttcg actacaatgc aaaatacgat gatgttagta caattgaaga
     2101 agttattgaa cttccaactg aaattaagga acgtgtaaat aaagcgtcat tggcttgtta
     2161 taaagcatta aaatgtagtg tttatgcaag ggttgatatg atggtgaagg acggaattcc
     2221 atatgtaatg gaggttaata cattaccggg gatgacccaa tcaagtttac tgccaaaaag
     2281 tgcagatgcc gcggggatta attatagtaa actattagat atgataattg aaacttcatt
     2341 aagagtgagg aaagaagaag gtttttaaga taattataca attaaaactt ttgatagttt
     2401 cacgaagtat gctatgataa ttacaatacg acaactaaat atttatccac taggggggcc
     2461 ttttgtaggc tgagatcaaa cataattttg agactcttag tacctgatct ggttaatacc
     2521 agcgtaggga agtgggaaga cgattatatt taaagaatac attaatattg tctatttcac
     2581 tttctttacg cctgtaaaga aagttttttt tgttttacag atttaataac tgtggataaa
     2641 tacgtatatt ttatacatta ttggaggaat ttaaatgact ttttcacaaa cattacgtaa
     2701 agaagtagat tctatttggg aggcaagttt tcatcatcct tttgtaaaaa aacttggtga
     2761 aggtacgtta gatttggcaa gttttcgtta ttacgtactt caagattcat attatttaag
     2821 tcattttgct agagtacaaa ctttaggagc tgcaaaggct ctagaattag aaacgacagc
     2881 tcgcatggca caccatgctc aaaatacata cgaggcagaa ttatcattac atgagaattt
     2941 cgcaaagaaa ttaggaatta cggaagaaga aaaaggtcat tttatccctg ctccaactgc
     3001 atatgcgtat acttcacata tgtaccgtgc ggcgtatgaa gggcatttag gggatattat
     3061 cgcagcaatt ttaccttgct actggctata ttatgaaatt ggtgaacgtt taaaagaatg
     3121 ccagccagaa gagccgattt ataaagagtg gatttctgct tatggatctg attggttccg
     3181 tactttagtt gaagagcaaa ttacacgatt agatactatc gctgaacaag tgacagagtc
     3241 tgatcagaag cgtatgaaac agcatttcat tattagtagt caatatgaat attcattttg
     3301 ggaaatggct tatacattag aaaaatggcc agtggataca gaagtaaaag atgtaattgg
     3361 ataaagagta gaggtattgt tatacatatg tatggataat acctctttat atgatttcaa
     3421 aaaaggggta tcgcaaaaaa gacgtatcaa tctaagtgcg tctttttttc aattttcttc
     3481 aattagcaat ttcatggaga gcttgctgga aaagtagaat gaaaagtcct aatcagggct
     3541 tttttttgta ggaatttctt aaccgtcatt gaatcctgtc actagtaggt gttttgacgc
     3601 tacgacggac tagattgttt attcgcctag tgaagtatat aaaaagttag gaatatccga
     3661 aggtgctctc agaaagtata tggaagtgtt ataacgagag gcatttacag tacagaaaaa
     3721 tctaagcggc atacgggaat acataggata cggcatcatg gttattgaga aatgaattga
     3781 acttagtaag catgaagata tgacgcaaga attcacattt tataatttct atttataaac
     3841 atgagcccat agtaaaaata ggtatatgaa caaggtgcac cgtctagtga taggtcatac
     3901 tttataggtg tacgtattga acttagttta tagcgttatt tctacttaga tttaacgaac
     3961 agaaatattg gaaagcatcg atgaggttaa agtttataaa cggaggtcat gaaaatgaat
     4021 aagtttcaac aagaactaca agcgttaagc cttaatgatt accagtctgg aaatattgtg
     4081 tattgggacc agcaaaacca atatccatac tactattttg aagatgctgc tcgtcgatgt
     4141 ggcggttgcg gtcgatgtgg cggttgcggt cgatgtggcg gttgtggagg tcgttgtggc
     4201 ggtggtggat tccgttgtgg tggattccgt tgtattggtt gcttcggttg ttttggttgt
     4261 ggcggctgtg gtggttgtgg tagttgtggt ggttgtggtg gttgttctaa ttgttttaat
     4321 ggttttaatg gtaccactga tactactggt actattgtaa catatgaata ttgataagag
     4381 agaaaaggaa tctactttgt aaagcgttat acaattttat aaaagagata aatcaaaaca
     4441 cacgtagcat cttttaattt agagaaataa tttatccaac cttttataaa tattgtgact
     4501 ttatttcaaa tcaaaaatcg aatgtctttt tatgtattat actcttgacg cactctttga
     4561 cttttataag cagatttatt gcaccagaac caaaaagaag agctgctatc agcccttctt
     4621 tctcttttct ttttaagatt gtaattctta tagcctgtat aatatctgtc cataaatgca
     4681 accatgtcac caaataatcc ccatttacct acatttatcc aacctttaac aactgccgat
     4741 tttaatgctt ttctccccgc atctttacga tcttttgctg ttatacctga ttttctgctc
     4801 attctcatac tttatatgaa atatgtgaaa atcagtatga atggtggaag tgagcgcaac
     4861 tttaaaagct atttatcggg attaacaaat ttaataatct atttttatta ctattgatta
     4921 attttgaaac gtaacaaaac tacgtaactg tttgtataaa atgcactgct ctagtattca
     4981 aaatttagaa catggaataa ggtgctttgt ttctacaagc tgtttttgtt ttacttcata
     5041 ttacgattta tagaccggga attacacttt aaatgtttat tactgtagca gttatgtttc
     5101 tttcactaat agtgttagtg gatgtaccaa ttcccgtggc attcagagat agcctgtata
     5161 cataagtacc agggggaggg gtatctatcc agactattga aacgttgtgt gttaaatttg
     5221 ttgaaacatt tactggtttt taaatatctt cttgaagctc catctgaacc gcaatagtaa
     5281 agacgcctct ttttagagcg agaattgaag atacagtaaa ttctgtaagg ggacttaggg
     5341 aaacataatc agatttgaaa actccttcta actttactat ttgattaacg cctacactaa
     5401 tagctggtaa tacgaggtta gttgggctag ttgcaggaat atgactttgg ttaaatgtaa
     5461 ctgaaacaat gccaggtggt ccggtgttac cggtcggtct agtaggggat tgaaaaggtt
     5521 gcataggtgg gagtgttggt ccaatcgaat tctggtttaa tgcagcagaa gataaaaact
     5581 cgtccaatat aattcacctc taaaaaattt atattactga tagtaaatgt aggcgttgag
     5641 caaagtgaca tggacaagcg gttgtatgtt aaaaattaaa caaaatagtt attttattaa
     5701 agaaaaaaca tgcacaaaaa ttgcgcatgt ataataaaaa gctatttctt gtctatgtaa
     5761 atatatgatt ggcttataca aaccgtgagt gtgtttgaga aaaatggtta tttattaaca
     5821 aatataaaga gcgcttttaa ggcgctcttt aaccaaaact aatattaaaa aagaataccg
     5881 catgatattt tatgtatgtt cttaataaat gtgcggtttt taaacaaaat ccttatttta
     5941 tcataaataa aaagagcaca catataagcg tgctctcaaa taagaaaggt agaatgctat
     6001 gaatggaaag cctcgataga ataacatatg cttgtccggt ttaaatgtga gaagttttta
     6061 ataaaaacgc tattttagaa aggaacaagt ttaaaaggcc ctgattgaca caggaccttt
     6121 taaaagggaa caacacttga catgttaaaa attatgactg aaaggtattt tcatattacc
     6181 attattgggg ttttaattcc aataatggtt gttgagaaat aaaaccttta ttttgcacaa
     6241 caaagcagct agctgaagta gctaattgct ttattgtaca attttagaag ttcactggat
     6301 acagatatat gttgtaacaa atagttacat ctatggtata aacaaatacc aaaatattat
     6361 gcaggaaaga aaactaaatt aaaacttcat tttataaaga gagaagcaca aaatattata
     6421 tgtgtatcca gtcaattgag tgcattttta ctaacaaaga gcagctagca aaagctaact
     6481 gttcggttct ccaaggggga acaaggagaa agtaacttaa tgggttgtct acattattga
     6541 cggaatctgg aggcttattc ggtcaaataa aaaaggtact gtatataagt gcactttgga
     6601 ccaagttttt tatggtaaca gttattggta ttatgtgtaa gaactaacgc gtatcttgaa
     6661 aataatgatt atttatttaa atgtaaattc ataattagag tagaatcgca tcaatacgct
     6721 cgcagttaac tacagtgata tctccgtttt catctataaa tgtagcaagg cgggatctat
     6781 tatggaatcc tacaaatata gaagctttta atattgtacc gttaactaac agctgtttta
     6841 ttttttttcc taagtaatat gtttctaaaa gatagcaaat atttttagaa ctctcttttt
     6901 gggttgggat aaaagaacgt cggttatttg gaagagatgt tagattagga ttgaatactt
     6961 tgggagtaat agcatagttg atgaaaactg gcatttttcc ggctcctcta ttttataatt
     7021 tatattgaaa tatgctgtgt gaaatagggc ttttttcaaa gccccatctt tactctactc
     7081 agcttcaatt ctaagcgctt gaatatcacg acagtccaaa acaattatag agccaggttc
     7141 tgttgtgtta tccacaaatg ttacacaaaa attatctgga ttaaagttag taaaaataag
     7201 atcctctagt gttgttcctg taaggaaaac atctacttct gtacctaact gtaatctttc
     7261 taattgttcg caaacacatt ttgtatgctc agccatataa aaacacctcc ttttctcaaa
     7321 ttactattaa tatatgtata aattaaatag aacgattgga gtaatagctt agtaatatta
     7381 attattttgc tagttaatat ttttataaaa taatcctttg aaatgaatat cgtccggcta
     7441 gaaaactaga ggacaccaat tcattaaagc agccattaaa gctgttttag gaataggtgt
     7501 cctttttatt ttgaaaaggg agatggggaa atgaatgtgt taagagatca attaagtgaa
     7561 tagaaaaagt aatcgaaaca aataaggaag aaaaaaatat agagttcaag tggttgtgag
     7621 ataaattgaa aatagaaatt gataattaaa aagataaata attaaaaatt tggatgtagt
     7681 gaatgcaaat gaaattaaaa ttaaaaaggt ataattttaa tttttaagtt aagtatagaa
     7741 aagaaatgaa tcatctagat ataaagaaag gatggatttt tgcaatgagc tcaaatgaat
     7801 caaatttcag ttttaccagt aataaagata ttgtaaagta ccttaatgta agaaaagacc
     7861 ctgttgattt aagagacaaa atatttcgga gttacttgtt tagtaatgag gcggatttgc
     7921 caacgcaagt cgatcttcgt cctaaaatgt caggtatagt aaaccaatgg aatataggtt
     7981 cttgtacggc gaatgcaatt gtttcagggt taagagaata cctattatta caatcaggtc
     8041 gtccatttac ttgcttatct cgtttgtttt tatattatca tgagcgagaa atagaaggac
     8101 atattcagga agatagcgga gcgaatgttc gtgatggtat ggatgttctt aaaaaaattg
     8161 gggtatgtcc tgaagaggat tttccttata ctgagaattt tagagataag ccatcaccaa
     8221 aggctgaatc agatgcaacg ctttataaaa ttggaaccta ccatcgtatt caagatttat
     8281 cgggattaaa ggctgcactt gcccatggat tagttgttgt acttggattt gctgtgccaa
     8341 aatcttttat gtcagaagaa gttaaaaaga ctggtatagt tccggtatca ggaacagatg
     8401 atgtaattgt tgaagatggt caacaggcag gacatgctgt ttgtgctgct ggatatgatg
     8461 ataataagaa aactgttatt attcgaaaca gctggggaga agagtgggga gataaaggat
     8521 attgttattt cccatatgaa ttatttgaaa atggaattgt acaagatatg tggacaggtc
     8581 gttaattaga taaagaagtg gaagtatgga aacaataaaa cacgttatac atgttacggg
     8641 tagtataaaa gagcttgaaa aagatgtgga aataaaggga gtcaggtttg ttacctacaa
     8701 cggaaaaaga tatgagtaat atttttatac aagctggtat tttaagtgaa cgaaaaacaa
     8761 atatagtccg gctagaaaac tagaggacac caattcatta aagcagcaat tcaagctgct
     8821 ttaggaatag gtgtcctttt ttttattttg gaaagggaga tggggaaatg aaggtgttaa
     8881 agaatcagct acgtgaatgg aaaaaccaat cgaaaaagaa aaataagaaa aaacgaaaag
     8941 agaaatttag tactcgtgaa attgaggatt tgatgggggt gcatagacct tgttatgaac
     9001 gcagacgtgg agcattaaga caaaagtaa
//
