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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP101637.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | cyclic-lactone-autoinducer | 2,436,327 | 2,457,137 |
Region 1.2 | ranthipeptide | 2,465,366 | 2,487,024 |
Region 1.3 | RRE-containing | 3,818,648 | 3,837,509 |
Region 1.4 | RRE-containing | 3,877,627 | 3,900,658 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | cyclic-lactone-autoinducer | 2,436,327 | 2,457,137 |
Region 1.2 | ranthipeptide | 2,465,366 | 2,487,024 |
Region 1.3 | RRE-containing | 3,818,648 | 3,837,509 |
Region 1.4 | RRE-containing | 3,877,627 | 3,900,658 |

No secondary metabolite regions were found in these records:
  NZ_CP101638.1
  NZ_CP101639.1

Compact view
NZ_CP101637.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,436,327 - 2,457,137 nt. (total: 20,811 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.13 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0001686.1 |  | 0.08 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000469.1 |  | 0.08 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0001941.1 |  | 0.07 | NRP, Polyketide | fulvuthiacene A, fulvuthiacene B | Myxococcus fulvus
BGC0001890.1 |  | 0.07 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001945.1 |  | 0.04 | NRP | chloromyxamide | Myxococcus sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.42 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0001686.1 |  | 0.30 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000469.1 |  | 0.30 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0001941.1 |  | 0.29 | NRP, Polyketide | fulvuthiacene A, fulvuthiacene B | Myxococcus fulvus
BGC0001890.1 |  | 0.28 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001945.1 |  | 0.21 | NRP | chloromyxamide | Myxococcus sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP101637.1 - Region 2 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,465,366 - 2,487,024 nt. (total: 21,659 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.17 | Other | nucleocidin | Streptomyces calvus
BGC0001887.1 |  | 0.14 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001540.1 |  | 0.14 | Other | CC-1065 | Streptomyces zelensis
BGC0001120.1 |  | 0.13 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001935.1 |  | 0.12 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.12 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0000695.1 |  | 0.11 | Saccharide | fortimicin | Micromonospora olivasterospora
BGC0001860.1 |  | 0.09 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.09 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000604.1 |  | 0.08 | RiPP | GE2270A | Nonomuraea sp. WU8817

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.48 | Other | nucleocidin | Streptomyces calvus
BGC0001887.1 |  | 0.44 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001540.1 |  | 0.43 | Other | CC-1065 | Streptomyces zelensis
BGC0001120.1 |  | 0.41 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001935.1 |  | 0.39 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.39 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0000695.1 |  | 0.37 | Saccharide | fortimicin | Micromonospora olivasterospora
BGC0001860.1 |  | 0.33 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.33 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000604.1 |  | 0.31 | RiPP | GE2270A | Nonomuraea sp. WU8817

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP101637.1 - Region 3 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,818,648 - 3,837,509 nt. (total: 18,862 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000938.1 |  | 0.16 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000294.1 |  | 0.16 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000551.1 |  | 0.16 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000554.1 |  | 0.15 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000513.1 |  | 0.15 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001210.1 |  | 0.15 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000487.1 |  | 0.15 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000906.1 |  | 0.14 | Other | heme D1 | Heliophilum fasciatum
BGC0001476.1 |  | 0.13 | Other (Nucleoside) | pseudouridimycin | Streptomyces sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000938.1 |  | 0.47 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000294.1 |  | 0.47 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000551.1 |  | 0.46 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000501.1 |  | 0.46 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000554.1 |  | 0.46 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000513.1 |  | 0.45 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001210.1 |  | 0.45 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000487.1 |  | 0.45 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000906.1 |  | 0.43 | Other | heme D1 | Heliophilum fasciatum
BGC0001476.1 |  | 0.42 | Other (Nucleoside) | pseudouridimycin | Streptomyces sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP101637.1 - Region 4 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,877,627 - 3,900,658 nt. (total: 23,032 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000782.1 |  | 0.21 | Saccharide | O-antigen | Burkholderia pseudomallei 1026b
BGC0000786.1 |  | 0.20 | Saccharide | O-antigen | Edwardsiella ictaluri 93-146
BGC0000790.1 |  | 0.19 | Saccharide | O-antigen | Escherichia coli
BGC0000787.1 |  | 0.19 | Saccharide | O-antigen | Escherichia coli
BGC0000760.1 |  | 0.19 | Saccharide | emulsan | Acinetobacter venetianus RAG-1 = CIP 110063
BGC0000777.1 |  | 0.18 | Saccharide | lipopolysaccharide | Escherichia coli
BGC0001655.1 |  | 0.17 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000761.1 |  | 0.17 | Saccharide | exopolysaccharide | Methylobacillus sp. 12S
BGC0000916.1 |  | 0.16 | Other | molybdenum cofactor | Staphylococcus carnosus
BGC0001863.1 |  | 0.16 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000782.1 |  | 0.54 | Saccharide | O-antigen | Burkholderia pseudomallei 1026b
BGC0000786.1 |  | 0.52 | Saccharide | O-antigen | Edwardsiella ictaluri 93-146
BGC0000790.1 |  | 0.52 | Saccharide | O-antigen | Escherichia coli
BGC0000787.1 |  | 0.51 | Saccharide | O-antigen | Escherichia coli
BGC0000760.1 |  | 0.51 | Saccharide | emulsan | Acinetobacter venetianus RAG-1 = CIP 110063
BGC0000777.1 |  | 0.50 | Saccharide | lipopolysaccharide | Escherichia coli
BGC0001655.1 |  | 0.48 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000761.1 |  | 0.48 | Saccharide | exopolysaccharide | Methylobacillus sp. 12S
BGC0000916.1 |  | 0.47 | Other | molybdenum cofactor | Staphylococcus carnosus
BGC0001863.1 |  | 0.47 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names