Select genomic region:
Overview
16.1
20.1
23.1

### Identified secondary metabolite regions using strictness 'relaxed'

c00016_NZ_CABK.. (original name was: NZ_CABKTY010000017.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 16.1 | NRPS-like | 102,623 | 150,569 | salinilactam | Polyketide | 8%

c00020_NZ_CABK.. (original name was: NZ_CABKTY010000021.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 20.1 | betalactone,terpene | 345,609 | 395,858 | herboxidiene | Polyketide | 4%

c00023_NZ_CABK.. (original name was: NZ_CABKTY010000024.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 23.1 | NRPS-like | 258,412 | 302,059 | acarviostatin I03 / acarviostatin II03 / acarviostatin III03 / acarviostatin IV03 | Saccharide | 7%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 16.1 | NRPS-like | 102,623 | 150,569 | salinilactam | Polyketide | 8%
Region 20.1 | betalactone,terpene | 345,609 | 395,858 | herboxidiene | Polyketide | 4%
Region 23.1 | NRPS-like | 258,412 | 302,059 | acarviostatin I03 / acarviostatin II03 / acarviostatin III03 / acarviostatin IV03 | Saccharide | 7%

No secondary metabolite regions were found in these records:
  c00001_NZ_CABK.. (original name was: NZ_CABKTY010000001.1)
  c00002_NZ_CABK.. (original name was: NZ_CABKTY010000002.1)
  c00003_NZ_CABK.. (original name was: NZ_CABKTY010000003.1)
  c00004_NZ_CABK.. (original name was: NZ_CABKTY010000004.1)
  c00005_NZ_CABK.. (original name was: NZ_CABKTY010000005.1)
  c00006_NZ_CABK.. (original name was: NZ_CABKTY010000006.1)
  c00007_NZ_CABK.. (original name was: NZ_CABKTY010000007.1)
  c00008_NZ_CABK.. (original name was: NZ_CABKTY010000009.1)
  c00009_NZ_CABK.. (original name was: NZ_CABKTY010000010.1)
  c00010_NZ_CABK.. (original name was: NZ_CABKTY010000011.1)
  c00011_NZ_CABK.. (original name was: NZ_CABKTY010000012.1)
  c00012_NZ_CABK.. (original name was: NZ_CABKTY010000013.1)
  c00013_NZ_CABK.. (original name was: NZ_CABKTY010000014.1)
  c00014_NZ_CABK.. (original name was: NZ_CABKTY010000015.1)
  c00015_NZ_CABK.. (original name was: NZ_CABKTY010000016.1)
  c00017_NZ_CABK.. (original name was: NZ_CABKTY010000018.1)
  c00018_NZ_CABK.. (original name was: NZ_CABKTY010000019.1)
  c00019_NZ_CABK.. (original name was: NZ_CABKTY010000020.1)
  c00021_NZ_CABK.. (original name was: NZ_CABKTY010000022.1)
  c00022_NZ_CABK.. (original name was: NZ_CABKTY010000023.1)

Compact view
c00016_NZ_CABK.. - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 102,623 - 150,569 nt. (total: 47,947 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001343.1 |  |  | 0.46 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000340.1 |  |  | 0.45 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0000389.1 |  |  | 0.44 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000375.1 |  |  | 0.44 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  |  | 0.41 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000957.1 |  |  | 0.40 | NRP, Polyketide | mycotrienin I | Streptomyces sp. XZQH13
BGC0001895.1 |  |  | 0.39 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001806.1 |  |  | 0.37 | NRP | tolaasin A | Pseudomonas tolaasii
BGC0001940.1 |  |  | 0.37 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000905.1 |  |  | 0.37 | Other | heme D1 | Heliobacillus mobilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001343.1 |  | 0.57 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000340.1 |  | 0.56 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0000389.1 |  | 0.55 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000375.1 |  | 0.55 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001225.1 |  | 0.54 | NRP | celesticetin | Streptomyces caelestis
BGC0000957.1 |  | 0.53 | NRP, Polyketide | mycotrienin I | Streptomyces sp. XZQH13
BGC0000427.1 |  | 0.53 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001895.1 |  | 0.53 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001940.1 |  | 0.51 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0001806.1 |  | 0.51 | NRP | tolaasin A | Pseudomonas tolaasii

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 102622 - 150569:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 102622 - 143949:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 107986 - 150569:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg16_131: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (44..448): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      haTvtArLIK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      50% (weak)
ctg16_134: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (28..420): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      hAmHtarLiK
    Nearest Stachelhaus code:
      hpg
    Stachelhaus code match:
      40% (weak)

c00020_NZ_CABK.. - Region 1 - betalactone,terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 345,609 - 395,858 nt. (total: 50,250 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000243.1 |  |  | 0.33 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0001779.1 |  |  | 0.33 | RiPP | siamycin | Streptomyces nodosus
BGC0001210.1 |  |  | 0.31 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000939.1 |  |  | 0.29 | Other | aerobactin | Grimontia hollisae
BGC0001498.1 |  |  | 0.29 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0000294.1 |  |  | 0.29 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000488.1 |  |  | 0.28 | RiPP | circularin A | Clostridium beijerinckii
BGC0001311.1 |  |  | 0.28 | RiPP | flavecins | Ruminococcus flavefaciens FD-1
BGC0000410.1 |  |  | 0.28 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001684.1 |  |  | 0.26 | Other | N-acyloxyacyl glutamine | Klebsiella variicola

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000646.1 |  | 0.57 | Terpene | β-carotein | uncultured bacterium
BGC0000634.1 |  | 0.56 | Terpene | carotenoid | Brevundimonas sp. SD212
BGC0000648.1 |  | 0.55 | Terpene | carotenoid | Myxococcus xanthus
BGC0000249.1 |  | 0.54 | Polyketide | nogalamycin | Streptomyces nogalater
BGC0000641.1 |  | 0.54 | Terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.1 |  | 0.53 | Terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000664.1 |  | 0.53 | Terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.1 |  | 0.53 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000938.1 |  | 0.50 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0001897.1 |  | 0.50 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00023_NZ_CABK.. - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 258,412 - 302,059 nt. (total: 43,648 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000375.1 |  | 0.34 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.32 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001249.1 |  | 0.28 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000900.1 |  | 0.28 | Other | ferrichrome | Aspergillus oryzae
BGC0000348.1 |  | 0.27 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0000979.1 |  | 0.25 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.25 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001561.1 |  | 0.23 | NRP | curacomycin | Streptomyces curacoi
BGC0001479.1 |  | 0.23 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001718.1 |  | 0.21 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000375.1 |  | 0.67 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.65 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001249.1 |  | 0.62 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000900.1 |  | 0.61 | Other | ferrichrome | Aspergillus oryzae
BGC0000348.1 |  | 0.61 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0000979.1 |  | 0.58 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.58 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001561.1 |  | 0.56 | NRP | curacomycin | Streptomyces curacoi
BGC0001479.1 |  | 0.56 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001718.1 |  | 0.54 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 258411 - 302059:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg23_220: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (26..397): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAESIGtVvK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      80% (moderate)