LOCUS       NZ_CP073653.1          10795 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP073653.1 Clostridium beijerinckii strain DSM 791 chromosome,
            complete genome.
ACCESSION   NZ_CP073653
VERSION     NZ_CP073653.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:43:32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3899898
            Orig. end    :: 3910693
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10795
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3904898:3905693](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5795)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10795
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10795
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(553..1374)
                     /locus_tag="ctg1_3473"
                     /transl_table=11
                     /translation="MENRLEAFLEVIPELKEILQDDIAVAVADTKKFIYYRDGDSINLP
                     IKVGQELSPEEPLYKSIKEGKVLSVIVPKELFGISFKGISYPIKDSSGNIIGGVGIGKS
                     LNKQLKVEEVAENIFSSLQQTSSSIEEVAVDSQRLSSSMNNIVDATQKTEEKIKETDTI
                     LNLIASVSSQSNLLALNAAIEAARAGEAGRGFSVVAGEMRKLSQMSSESSKKVSQLLLE
                     MRNSIDEVIKEISNTNMIAESQAAATEEITATLEEITSNSKELVDMSKVVW"
     PFAM_domain     complement(574..954)
                     /aSDomain="MCPsignal"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00015.23"
                     /description="Methyl-accepting chemotaxis protein (MCP)
                     signalling domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3473_0065"
                     /evalue="9.40E-29"
                     /label="ctg1_3473"
                     /locus_tag="ctg1_3473"
                     /protein_end="267"
                     /protein_start="140"
                     /score="100.5"
                     /tool="antismash"
                     /translation="SSMNNIVDATQKTEEKIKETDTILNLIASVSSQSNLLALNAAIEA
                     ARAGEAGRGFSVVAGEMRKLSQMSSESSKKVSQLLLEMRNSIDEVIKEISNTNMIAESQ
                     AAATEEITATLEEITSNSKELVD"
     CDS             1661..1978
                     /locus_tag="ctg1_3474"
                     /transl_table=11
                     /translation="MKKFIPIFLIFFFISTCFNIKGVSAAPKTFKQGIYTWSDSGLPAN
                     SSLTIKLGESTSKAIVMVIDSDQTMEALLRLNARVTHQVLPPLTYTSSIIIFTDGNVIF
                     S"
     CDS             complement(2598..3101)
                     /locus_tag="ctg1_3475"
                     /transl_table=11
                     /translation="MELINGNSNQIDKTRESIKKLIEDYKIELEVLSRMINVDYNWLKD
                     YMDGKRNLHEFYANAMDSIKNNKEFVWNPKCPEPSLLSNKIYILSEGIRSINEDDRVKG
                     IIDVLIIDVGIRYDTLAMYAGISLEDVKNFMNDTNSITYENKYKLAVASLFLHFLINGK
                     KSAN"
     CDS             complement(3461..4261)
                     /NRPS_PKS="Domain: PKS_KR (5-178). E-value: 5.1e-11. Score:
                     34.6. Matches aSDomain: nrpspksdomains_ctg1_3476_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     175.2; E-value: 2.8e-53)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3476"
                     /transl_table=11
                     /translation="MKNETVVLITGCSTGIGRELCSILSERGYIVVATARNVETLKDLP
                     VSLKLSLDVTQKESISVAMEEVIARFKKIDILVNNAGYSTRGALEEIDVRSAKSMFDVN
                     VFGIINMIQVVVPEMRKKQFGKIINIGSISGKFVQPINGAYCASKYAVEAISDALRLEL
                     HNNNIQATVIEPGPIKTNFFKTMANNSNNLMTNQDSYYSTFYEADAKYRNDQNLTNLKE
                     AAKTIVNIISKRRLKPRYKVAVPLAYNIAIHFPDFVREYFMKKR"
     PFAM_domain     complement(3701..4246)
                     /aSDomain="adh_short"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00106.27"
                     /description="short chain dehydrogenase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3476_0066"
                     /evalue="1.50E-48"
                     /label="ctg1_3476"
                     /locus_tag="ctg1_3476"
                     /protein_end="187"
                     /protein_start="5"
                     /score="165.0"
                     /tool="antismash"
                     /translation="VVLITGCSTGIGRELCSILSERGYIVVATARNVETLKDLPVSLKL
                     SLDVTQKESISVAMEEVIARFKKIDILVNNAGYSTRGALEEIDVRSAKSMFDVNVFGII
                     NMIQVVVPEMRKKQFGKIINIGSISGKFVQPINGAYCASKYAVEAISDALRLELHNNNI
                     QATVIEPGPIKTNFFKTMA"
     aSDomain        complement(3728..4246)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_3476_PKS_KR.1"
                     /evalue="5.10E-11"
                     /label="ctg1_3476_PKS_KR.1"
                     /locus_tag="ctg1_3476"
                     /protein_end="178"
                     /protein_start="5"
                     /score="34.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLITGCSTGIGRELCSILSERGYIVVATARNVETLKDLPVSLKL
                     SLDVTQKESISVAMEEVIARFKKIDILVNNAGYSTRGALEEIDVRSAKSMFDVNVFGII
                     NMIQVVVPEMRKKQFGKIINIGSISGKFVQPINGAYCASKYAVEAISDALRLELHNNNI
                     QATVIEPGPI"
     CDS_motif       complement(4178..4246)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_3476_0001"
                     /evalue="2.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_3476"
                     /protein_end="28"
                     /protein_start="5"
                     /score="13.7"
                     /tool="antismash"
                     /translation="VVLITGCSTGIGRELCSILSERG"
     CDS             complement(4325..4924)
                     /gene_functions="regulatory (smcogs)
                     SMCOG1133:Transcription regulator, crp (Score: 69; E-value:
                     5.7e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_3477"
                     /transl_table=11
                     /translation="MSKNVYDDLWIDILKNNGIFLSEKNITLLKKIFKPKLLKKDMFFL
                     QEGEKSTEIGVVVKGVFRSYYTDKAGKDTTKYFYKEGGVLFSYVAHLSQKESMYYIQAL
                     EDSEIIVAQISDFEKIVEENYELLLFYKKMIDNVLIMKEEHAISFKVLDSIERYKQFLN
                     AYPGLEKRIKQYNIASYLGMTPVSLSRLRKDLNINK"
     PFAM_domain     complement(4553..4813)
                     /aSDomain="cNMP_binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00027.31"
                     /description="Cyclic nucleotide-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3477_0067"
                     /evalue="2.70E-08"
                     /label="ctg1_3477"
                     /locus_tag="ctg1_3477"
                     /protein_end="124"
                     /protein_start="37"
                     /score="33.9"
                     /tool="antismash"
                     /translation="LKKDMFFLQEGEKSTEIGVVVKGVFRSYYTDKAGKDTTKYFYKEG
                     GVLFSYVAHLSQKESMYYIQALEDSEIIVAQISDFEKIVEEN"
     CDS             complement(5001..5795)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3478"
                     /sec_met_domain="DUF692 (E-value: 1.3e-15, bitscore: 55.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYIGCNWSKALKFLIEENLIRVDYIKSFGYGNFKEDFKTMRSMRP
                     ILVHGLGYYENTGMNDIERIDFNSANSIIRKCNSPHYGLHLAIRSKDMLTGMTEDDIYK
                     RMSNQIQFFKKSLSVPLLLENSPDTPHDRKVFDLYPYVMPEQIYNLVVENDVSFLLDIT
                     HARITAKYRGWDVYEYIGRLPLDHVVEIHTNGSGHDENGFPMDTHQAMEEEDYELLEWV
                     LDRTNPKIVTLEFNEVETEDYNKIIYSLEKQLNRIYDICSTR"
     PFAM_domain     complement(5088..5705)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3478_0068"
                     /evalue="4.10E-17"
                     /label="ctg1_3478"
                     /locus_tag="ctg1_3478"
                     /protein_end="236"
                     /protein_start="30"
                     /score="62.3"
                     /tool="antismash"
                     /translation="GNFKEDFKTMRSMRPILVHGLGYYENTGMNDIERIDFNSANSIIR
                     KCNSPHYGLHLAIRSKDMLTGMTEDDIYKRMSNQIQFFKKSLSVPLLLENSPDTPHDRK
                     VFDLYPYVMPEQIYNLVVENDVSFLLDITHARITAKYRGWDVYEYIGRLPLDHVVEIHT
                     NGSGHDENGFPMDTHQAMEEEDYELLEWVLDRTNPKIVTLEFN"
     CDS             complement(6093..7352)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 220.2; E-value: 7.4e-67)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_3479"
                     /transl_table=11
                     /translation="MLIKVLSLKKFSRNKELLNIGLFSIANFISVFGTSIYNFAISLYV
                     LKITGSGLNFAMTLVIGALSTVLVNPFAGVLADKINKKLLTVITDALNGMLLLVLYILT
                     IEHPLSLSMIYLSTFILNVFSNIYGISIETAKPNLVSEKKLLQINSISKIIESSSSILG
                     PMIGGMIFALLDIRLFIIINSFSFGMSAFLQLFMDFLFNHSNEEKDGEKFNIFTDITYG
                     VTYLRSKKDIVNMLGIFIALNFFIGLSINVPMPYIVNNILKLSSNLFGIIQAFFSIGMI
                     VGALTIRKALNKFSHQKIVKVMTNILSICMIAIGFSVIIQYKIYDNNNLYVIYFCSIML
                     LAGISISVIDIAIFYELQQTIPNAIRGRVLSIGISIAKITLPIALIIAGSLINLIPAYI
                     LPIISGVGLWIFTMLYVRND"
     PFAM_domain     complement(6219..7280)
                     /aSDomain="MFS_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05977.15"
                     /description="Transmembrane secretion effector"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3479_0069"
                     /evalue="2.40E-16"
                     /label="ctg1_3479"
                     /locus_tag="ctg1_3479"
                     /protein_end="378"
                     /protein_start="24"
                     /score="59.4"
                     /tool="antismash"
                     /translation="IANFISVFGTSIYNFAISLYVLKITGSGLNFAMTLVIGALSTVLV
                     NPFAGVLADKINKKLLTVITDALNGMLLLVLYILTIEHPLSLSMIYLSTFILNVFSNIY
                     GISIETAKPNLVSEKKLLQINSISKIIESSSSILGPMIGGMIFALLDIRLFIIINSFSF
                     GMSAFLQLFMDFLFNHSNEEKDGEKFNIFTDITYGVTYLRSKKDIVNMLGIFIALNFFI
                     GLSINVPMPYIVNNILKLSSNLFGIIQAFFSIGMIVGALTIRKALNKFSHQKIVKVMTN
                     ILSICMIAIGFSVIIQYKIYDNNNLYVIYFCSIMLLAGISISVIDIAIFYELQQTIPNA
                     IRGRVLSIGISIAK"
     CDS             complement(7488..8705)
                     /locus_tag="ctg1_3480"
                     /transl_table=11
                     /translation="MKIGKFVKANNLTIDTVRHYINMTLIIPEKHGGQYNFDDRCQSDL
                     EDILLLKGMGFSLSEIKSIFMFKRLAKLTKYEENECFKSFFVNKDKEIGNKIRELNLMK
                     QKLKTKLELLSNVEIKDKSVIGIDLKALDLLRCFKCKKDLKLREGNIANNQVINGKLIC
                     SCGEEYIIKDGVLRVSNIKIDSDFKFDFNYITDYINSTDTTYLDNVYRGMDWIYKKIDF
                     ENLQNKVLLELGSGIGFFLRNVYKNLPDDSIYIAVDNDINKHLFLKNILESINCKKKIL
                     FICSDFEQIPIKDKSIDMLLDISGTSNYSFDHEEFLLELADRYVKDSSNIIGTYILFKN
                     FASNCLIEDKYRKNFILNNVKEQISKLDYNIFEENVSNYIEKGGKYESYFRDGEKVYSY
                     LIFGKR"
     CDS             complement(8932..9843)
                     /locus_tag="ctg1_3481"
                     /transl_table=11
                     /translation="MARKYNLYQVDSFTKEKFTGNPAGVISNADGLTDYEMQKIARELN
                     NSETAFIFSSNSSEYDVQVRFFTPISEVPICGHATIAAHYVRAIENELETSRIYHKTGA
                     GILPVDIIKENNDYKIIMTQGKIEFGEIIDGINKEELLKALKIKESDLLDDYKIQIVST
                     GHSKVMIGIKSIETLNTLQPDYSALSKLSEIIKCNGYYIFTTDSKESDILIHGRMFAPS
                     IGINEDPVTGNANGPLGAYLVHYNLVKHNNSLFRFKAKQGEAINRPGIIEVEVKIEDNE
                     PIETKVSGNAVIIFKSELLLND"
     aSDomain        complement(8947..9834)
                     /aSDomain="TIGR00654"
                     /aSTool="tigrfam"
                     /description="PhzF_family: phenazine biosynthesis protein,
                     PhzF family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3481_0017"
                     /evalue="1.80E-90"
                     /identifier="TIGR00654"
                     /label="ctg1_3481"
                     /locus_tag="ctg1_3481"
                     /protein_end="299"
                     /protein_start="3"
                     /score="301.3"
                     /tool="antismash"
                     /translation="KYNLYQVDSFTKEKFTGNPAGVISNADGLTDYEMQKIARELNNSE
                     TAFIFSSNSSEYDVQVRFFTPISEVPICGHATIAAHYVRAIENELETSRIYHKTGAGIL
                     PVDIIKENNDYKIIMTQGKIEFGEIIDGINKEELLKALKIKESDLLDDYKIQIVSTGHS
                     KVMIGIKSIETLNTLQPDYSALSKLSEIIKCNGYYIFTTDSKESDILIHGRMFAPSIGI
                     NEDPVTGNANGPLGAYLVHYNLVKHNNSLFRFKAKQGEAINRPGIIEVEVKIEDNEPIE
                     TKVSGNAVIIFKSEL"
     PFAM_domain     complement(8956..9816)
                     /aSDomain="PhzC-PhzF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02567.18"
                     /description="Phenazine biosynthesis-like protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3481_0070"
                     /evalue="2.00E-74"
                     /label="ctg1_3481"
                     /locus_tag="ctg1_3481"
                     /protein_end="296"
                     /protein_start="9"
                     /score="250.7"
                     /tool="antismash"
                     /translation="VDSFTKEKFTGNPAGVISNADGLTDYEMQKIARELNNSETAFIFS
                     SNSSEYDVQVRFFTPISEVPICGHATIAAHYVRAIENELETSRIYHKTGAGILPVDIIK
                     ENNDYKIIMTQGKIEFGEIIDGINKEELLKALKIKESDLLDDYKIQIVSTGHSKVMIGI
                     KSIETLNTLQPDYSALSKLSEIIKCNGYYIFTTDSKESDILIHGRMFAPSIGINEDPVT
                     GNANGPLGAYLVHYNLVKHNNSLFRFKAKQGEAINRPGIIEVEVKIEDNEPIETKVSGN
                     AVIIFK"
     CDS             complement(10016..10738)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     62.9; E-value: 5e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3482"
                     /transl_table=11
                     /translation="MSKINVLDISFDFSGQSDAIHPVILEDENEMILIDCGYPNFLSLI
                     EEAALAKNINVKDLSKIIITHHDYDHMGALAEFKRKYPKVKVLASEEDAPYIDGSKKSL
                     RLQQAENIYDSLSENEKVEADHFHKMLQSIESCNVDIKLKDRDYFDCCGGIGILATPGH
                     MPGHISIYHKESKSLITGDALVVENGELVIAVPQYTLDMKEAQNSVKKFLDYDIERIIC
                     YHGGIFENEISDALKRVF"
     PFAM_domain     complement(10067..10672)
                     /aSDomain="Lactamase_B"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00753.29"
                     /description="Metallo-beta-lactamase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3482_0071"
                     /evalue="1.80E-21"
                     /label="ctg1_3482"
                     /locus_tag="ctg1_3482"
                     /protein_end="224"
                     /protein_start="22"
                     /score="77.2"
                     /tool="antismash"
                     /translation="VILEDENEMILIDCGYPNFLSLIEEAALAKNINVKDLSKIIITHH
                     DYDHMGALAEFKRKYPKVKVLASEEDAPYIDGSKKSLRLQQAENIYDSLSENEKVEADH
                     FHKMLQSIESCNVDIKLKDRDYFDCCGGIGILATPGHMPGHISIYHKESKSLITGDALV
                     VENGELVIAVPQYTLDMKEAQNSVKKFLDYDIERIICYH"
ORIGIN
        1 ctattgaata tgctttaaaa attataaatg gaaaatggaa attattaatc atttgggtta
       61 tatctcaaaa tggaattgtt cgctttaatg aactacagcg aaaagttgat ggcatatcca
      121 gtcttatgct ctcaaaaaac ttaaaagaac ttgaagaaga ctctcttgtt attcgtcacc
      181 aatacaatga gattccacca agagtagaat atgaattatc agaacttagt caaaagctca
      241 tagttgcttt acaacatctt ggcgaatggg gagaagaagt ttataaacat aaagaaacat
      301 ctttgtaatg aataatcaaa agttttcttc aaccacgaat aatatactta tactacttca
      361 tagctatatg cccttttata tttaggcaga aaaaaatcgc atattcatat tttattgaac
      421 aatgcgatct tctgcttatt ttatactatt atcctattaa attttcctga taaattttat
      481 gaaggttgtt aaataatcta ataagataat tgctaaaatt atatgtatct gaagtaaatg
      541 ctataatcat ctttaccata ctacctttga catatccact agttccttgg agtttgaggt
      601 aatctcttct aaagtagccg ttatctcttc agtagctgct gcttgtgatt ctgctatcat
      661 gtttgtattg ctaatctcct taataacttc atcaatagaa tttctcattt caagaagcaa
      721 ttgtgatact ttctttgacg attcactgct catctgtgaa agttttctca tttcacctgc
      781 aacaactgaa aaacctcttc ctgcctcgcc tgctcttgca gcttcaatag ctgcatttaa
      841 agctagaaga ttagattgag aagaaacact ggcaataaga tttaatatcg tatccgtttc
      901 ttttattttt tcttctgttt tttgtgttgc atctacaata ttattcattg aagatgaaag
      961 tctttgagaa tcaacagcca cttcctcaat gcttgagctt gtctgttgca gtgaactaaa
     1021 aatattctct gctacttctt ctactttaag ctgcttattt aagcttttac ctattccaac
     1081 cccaccaata atatttccac ttgaatcctt aattggatag gaaattccct taaatgatat
     1141 tccaaacaat tcttttggca ctatcacact cagtacctta ccttctttta tacttttata
     1201 taaaggttcc tcaggactca attcttgtcc cactttgata ggtaagttaa tggaatcacc
     1261 atcacgataa tatataaatt tcttagtatc tgctacagca actgctatat cgtcttgtaa
     1321 tatttccttt aattcaggaa taacctctaa aaatgcctca agtctatttt ccatatatac
     1381 accctccagt aaattcaatc tatgataggt atatattcga taattctttc tatattcctt
     1441 gtttttttgc gtttatttta gaaatatatt attttatttt ttagcgttat ttattttaaa
     1501 tcaataattc ttttaaaaaa ggccctttaa ttatcacata cataaatacc tcgacaagtg
     1561 gtattttttg tttaatctat atgttgaata tttcaaccct aaatacgcat aatacaaatg
     1621 atatattata taaaatttaa cattaaaggt ggttaaacta atgaaaaaat ttattcctat
     1681 attcttaatt tttttcttca tatctacttg ctttaatatt aaaggtgtat ctgccgcccc
     1741 taaaacattt aaacaaggca tttacacttg gagcgattca ggcttaccag ccaattcatc
     1801 tcttactata aaacttggcg aatctactag taaagctata gttatggtta ttgattcaga
     1861 ccaaactatg gaagctctat taagattaaa tgctcgagtt acccaccagg ttttacctcc
     1921 acttacatac acttcttcaa ttataatctt tactgatggt aatgtaatat tttcataaaa
     1981 gttaatttaa aactgacttt cccatacggt attatttcta gaatctcatt tataggtaat
     2041 tgtgtgttta catgaggaat atggtctaag ataatgcttt tgattaagtt ttacatattg
     2101 gggaatataa atttatcttc acatttgcca ttattctgac ataataaaca actataataa
     2161 aatcataaac ttaataaaaa ctttttttca tatatatttc ccaaaatata taaaacaaag
     2221 agtaatattc atattcccca tatgtttatt actctttttt gcatttcaaa taactattaa
     2281 attcatacat acttcttaca tagcatacat acaaaaatgc tatactttga ttactttcat
     2341 attggctatt ttttatttca tgttacttta aaatttcaca taaatattga ttacctatta
     2401 cctccacatg atttaaatat tgatccaact ctattattta aatcaaaata accagtatcc
     2461 attaatattg ttggtttaac ttttagggca tttggtctcc cattttccaa acaatcttcc
     2521 tttgcatatg ttgccacaat ctcaccaaga aacattgtaa aatcaaatat gggaatggtt
     2581 tgtatcacct tacacaacta atttgctgat ttcttgccat taatcaaaaa atgtaaaaac
     2641 aagcttgcta ccgctaactt atatttattt tcatatgtaa tagaattagt atcattcata
     2701 aaattcttaa catcttctaa gctgatacct gcatacatag ctaaagtatc gtatctaatt
     2761 ccaacgtcaa ttatcaatac atctattatt cctttgactc tgtcatcttc atttatacta
     2821 cgtatccctt cagatagaat ataaatctta tttgataata atgaaggctc gggacacttt
     2881 ggattccaca caaattcttt attgttttta atagagtcca ttgcattagc ataaaactca
     2941 tgcaaatttc tttttccatc catataatct tttagccagt tataatccac atttatcatt
     3001 ctactcaaaa cttcaagttc aattttataa tcttcaatca atttttttat actttctctt
     3061 gttttatcaa tctgattaga atttccattt attaattcca tatcttctca cctaattctg
     3121 taatatattt taatattttt ttaaatacat atttataaaa attggttatt taacactcta
     3181 aattaatgct aatcaatttt acaataatgt ccttcaattc tcttataagg tattaatata
     3241 tctgcagtct gaactctatt tagaaaatct tttaaactct ctataacata tccctgaatt
     3301 attgagagta taattcaaat tcaatgtttt ctgtaatata tttttcttgt cgcaaggttc
     3361 agtaattttt actctataga gctttacttg ttttaaaaat gtcattattg atttatcccc
     3421 ttccatattc tgctactata aattataatt attcattaat ctagcgcttt ttcataaagt
     3481 attctcttac aaagtcagga aagtgtatag ctatattata tgcaagcgga acagcaacct
     3541 tataacgagg tttaagtctc cttttcgaaa ttatattaac aatagttttc gctgcttctt
     3601 taagattagt taaattttga tcatttcgat atttagcatc tgcttcataa aaagttgaat
     3661 aataagaatc ttgattagtc ataagattat ttgaattatt agccatagtt ttaaaaaaat
     3721 ttgtttttat tggtccaggt tctattacag ttgcttgaat attattgttg tgcaattcta
     3781 aacgcaatgc atcacttatt gcctcaactg catatttaga tgcacaatat gcaccattaa
     3841 taggttgaac aaatttcccc gaaattgaac cgatatttat aattttgcca aattgtttct
     3901 tacgcatttc cggaacaact acctgaatca tattaattat cccaaataca ttcacgtcaa
     3961 acatgctttt tgcacttctt acatcgattt cttctaaagc acctctagtt gagtatcctg
     4021 cattatttac aaggatatca attttcttaa atcgtgctat cacttcctcc atcgcaactg
     4081 aaatagattc tttttgggta acatctagtg atagctttaa tgatacaggt aaatctttta
     4141 aagtttctac atttctagct gttgccacaa ctatatatcc tctctcagat aatatgctgc
     4201 aaagttctcg tcctatcccc gttgagcatc ctgtaattaa aacaactgtc tcatttttca
     4261 tataaattac ccccattaat aaaatttata tacatcataa atcacatgga ggttagctgc
     4321 attatcattt gttaatattt aaatcttttc ttaatctact aagtgacaca ggggtcattc
     4381 ctaaataaga agcaatatta tattgtttaa tacgcttttc taatcctgga tatgcattga
     4441 ggaactgctt ataacgttca atgctatcta atactttaaa actaattgca tgctcttctt
     4501 tcataataag aacattatca atcatctttt tgtaaaacaa aagtagctca tagttttcct
     4561 caactatttt ttcaaaatca gaaatttgag ctacaataat ttcgctatct tctaatgctt
     4621 gtatataata catagattcc ttttgagata gatgtgctac atatgagaat agtaccccac
     4681 cctctttgta aaaatatttt gttgtatctt tgcctgcttt atcagtataa taagaacgaa
     4741 aaactccctt aacaacgact cctatttcag tagacttctc accttcctgt aaaaagaaca
     4801 tatctttttt taatagcttt ggcttaaaaa tcttctttaa taaagttatg tttttttcac
     4861 taaggaaaat cccattattt ttcaaaatat ctatccataa atcatcgtat acatttttac
     4921 tcatttaaag cctcgttcct ttggtttgaa ataattattc ttacacctct tatactttta
     4981 ttcttattta ttaattttac ttatctcgta ctgcatatat catatattcg atttaattgt
     5041 ttttctaatg aataaatgat tttgttataa tcctctgttt ctacttcatt aaattccaat
     5101 gtaactattt tcggatttgt acgatcaaga acccactcta acaattcgta gtcctcttct
     5161 tccatggcct gatgtgtatc cattggaaaa ccattttcat catgacctga accatttgta
     5221 tgaatttcta caacatgatc aagtggtaac cttccaatat actcataaac atcccatcct
     5281 cgatattttg ctgtaatcct tgcatgggtt atatcaagca agaaagatac atcattttca
     5341 acaactagat tataaatctg ttctggcatt acataaggat aaaggtcaaa tactttacgg
     5401 tcatgtggtg tatcaggaga attttcaagt aataatggaa ctgataaact ctttttaaag
     5461 aactgaattt gattagacat gcgtttatat atgtcatctt ctgtcatacc tgttaacata
     5521 tccttagatc ttatagcaag atgaagacca taatgtggtg aattacattt ccttatgata
     5581 ctattcgcag aattaaaatc aatcctctct atatcattca ttcctgtgtt ttcataatag
     5641 cctaaaccat gtactaaaat tggtcgcatt gaacgcatag ttttgaagtc ttctttaaaa
     5701 tttccatatc caaatgattt aatatagtct actcttatca agttctcctc tataagaaat
     5761 tttagtgctt ttgaccagtt acacccaata tacattttag aatttcctct ctacataatt
     5821 aatttattta tttgaataca ctaatactat aattaactaa tcagccattt tatgtaactt
     5881 aattatagca tattttataa aattctatta ttcaatttct aaaggatatc tttatagaat
     5941 cctttagaaa atttgcatct ttgtattctt gtttgaataa ctcagtcgta atctttaaat
     6001 ataataatat agttatcgtt cttgctgcta atctccattt atcctcatca taatctcgga
     6061 taaatttaat atcattttct tatcacataa aattagtcat ttctaacata tagcatagta
     6121 aaaatccaaa gccctacacc gcttattata ggcaaaatat atgctggtat aagatttatt
     6181 aaactacctg ctataattag tgcaataggt aaagttattt ttgctatgct gattcctata
     6241 ctaagtactc tccccctaat ggcattcgga atagtttgtt gcaattcata aaatatagct
     6301 atatcaatta ctgatatgga tatgcctgct aataacatta ttgagcaaaa atatattaca
     6361 tagaggttat tattatcata gattttatac tgaattataa cagaaaagcc tattgctatc
     6421 atgcaaattg ataatatatt agtcattact tttacgattt tctgatgtga gaatttattc
     6481 agagcttttc ttattgtaag cgctccaaca atcattccta ttgagaaaaa agcttgtatt
     6541 atcccaaaca aattagaact caattttaaa atattattta ctatataggg cattggtaca
     6601 tttattgaaa gaccgataaa gaaatttaaa gcaataaata ttccaagcat attcactatg
     6661 tcttttttac ttcttaaata agttactcca taagttatat cagtaaaaat attaaatttt
     6721 tctccatctt tttcttcatt gctgtgatta aatagaaaat ccataaataa ctgaagaaat
     6781 gcggacatcc caaaagaaaa actattgatt attatgaaaa gccttatatc taataaagcg
     6841 aaaatcatcc caccaatcat tggcccaagt atggaagatg aagattcaat tattttacta
     6901 atagaattta tctgaagtag ctttttttct gatactagat ttggttttgc agtttcaata
     6961 cttatcccat atatattaga aaatacattc aatataaagg tacttaaata aatcatagat
     7021 aaactcaaag gatgttcaat ggttaggatg tatagaacaa gcaatagcat accatttaaa
     7081 gcatctgtaa ttactgtgag tagtttctta ttaattttat cagcaagcac tccagcaaat
     7141 ggatttacaa gaacagtaga taatgctcct attactaaag tcatagcaaa atttagacct
     7201 gaaccagtaa tttttaatac atacaagcta atagcaaaat tatatataga tgttccaaat
     7261 acagatataa agtttgcaat tgaaaataaa cctatattta ataactcttt attcctcgaa
     7321 aattttttta gtgatagaac ttttattaac attgttaatc tcactttccc ttaatgataa
     7381 tttacttttt taaaatttaa tttaatttta aatagtggtc ttatcaccat atcaataggt
     7441 taattaacaa aattttatga taaaataaat aaaagatagg gttaacccta ccttttacca
     7501 aagattaaat atgaatatac tttttctcca tctctaaaat agctctcata ttttccacct
     7561 ttttctatat agtttgatac attttcctca aaaatattat agtcaagttt tgaaatctgt
     7621 tctttaacat tgtttaaaat aaaatttttc cgatatttat cttcaattaa acagtttgat
     7681 gcaaaatttt taaataaaat atacgtccct attatatttg aactatcctt tacatatcta
     7741 tcagctagct ccaataaaaa ctcttcatga tcaaagctgt aattgcttgt acctgaaatg
     7801 tctaaaagca tatcaataga tttatctttt atagggattt gctcaaaatc agaacaaata
     7861 aataatatct ttttcttaca atttatactc tctaatatat tttttaaaaa taaatgctta
     7921 tttatatcat tatcaacagc aatgtatatt gaatcatcag gtagattttt ataaacattt
     7981 cttagaaaaa atccaattcc tgaacctaat tcaagcaaaa ctttgttttg caaattttca
     8041 aaatcaatct ttttataaat ccaatccatt ccacgataga cattatcaag ataggttgta
     8101 tcagtagaat ttatataatc tgtgatgtaa ttaaagtcaa acttaaaatc agaatctatt
     8161 tttatattag aaactctcaa tactccatct ttaattatgt attcctctcc acaagagcaa
     8221 atcaatttcc catttataac ttggttattt gctatatttc cttcacgaag ctttaaatcc
     8281 tttttacatt taaaacatct caaaagatca agagccttta aatctatacc tataacggat
     8341 ttatctttaa tttctacatt tgaaagcaac tctagttttg ttttaagctt ttgcttcatt
     8401 aaattaagtt ctcttatttt gtttcctatc tctttatctt tgtttacgaa aaatgattta
     8461 aaacattcat tctcctcata ctttgtaagt tttgccaatc ttttaaacat gaaaattgat
     8521 ttaatttcac ttaatgaaaa tcccattcct ttaagtaata gtatatcttc caaatcactt
     8581 tggcatctat catcaaagtt atattgccct ccatgttttt caggtattat caaagtcata
     8641 tttatataat gacgcacagt atcaatagtt aaattgttag ctttaacgaa cttaccaatt
     8701 ttcatataat tcctccatct ataatgaact tcgataacag ctctttcaat agctccacat
     8761 aatatccaat taattaaatt cttttaaaat tatcattgcc tactttgaat tgatcattta
     8821 gctatgttct cagcttgcag attctttgtt agactgctta tataatttat taataatatt
     8881 tttgtataaa tgactctgcc ataaaatttg attattatag aataaacttt tttaatcatt
     8941 taataataat tctgatttaa atattataac ggcgtttcct gaaactttgg tctctattgg
     9001 ttcattgtct tctatcttta cttcaacttc gattatacca ggcctattta tagcctctcc
     9061 ttgcttagct ttaaatctaa ataaagaatt attatgctta acaagattgt aatgaacaag
     9121 atatgcacct aatggaccat ttgcattacc ggtaacagga tcttcattga tacctattga
     9181 aggtgcaaac attcttccat gtattaaaat atcactttct tttgaatcag tagtaaaaat
     9241 ataatatcca ttacatttaa tgatctcgct taacttagaa agtgcactat aatctggctg
     9301 caatgtattt aaggtttcaa tacttttaat acctatcata actttagaat gacctgttga
     9361 cactatctga attttataat catcaagtaa atcactttct ttaattttaa gtgcttttaa
     9421 aagttcttct ttatttatac catcaataat ttcaccaaac tcaatttttc cctgtgtcat
     9481 aataattttg taatcattat tttcttttat tatatcaaca ggtaaaattc ctgctcctgt
     9541 cttatgataa atccttgaag tttccagttc attttcgata gcacgtacat aatgagctgc
     9601 aatagtggca tgtccacaaa taggaacctc gcttataggt gtaaaaaagc gtacttgaac
     9661 atcatactca ctactatttg aagagaaaat aaatgctgtc tcagaattgt taagctctct
     9721 agcaattttc tgcatttcat aatcagttaa tccatctgca tttgatatta cccctgctgg
     9781 atttcctgta aatttctcct ttgtaaatga atcaacttga tataaattat attttcttgc
     9841 catgttacct ccagatatac tttaatttat aggctaaaac catttcttta atccatggga
     9901 attaatacct atccgtaata taattaatta tagttttact ttaattcact tacaagtgcg
     9961 cattttaaaa gtaagattta tgtttggatt gaaaaaataa taaaaattgc ctaacttaaa
    10021 aaactctttt aagagcatca ctgatttcat tctcaaatat tccaccatga tagcatataa
    10081 ttctttcaat atcataatcc aaaaactttt taacagaatt ttgggcttct ttcatatcta
    10141 gggtatattg aggtactgca ataacaagtt ctccgttttc tacaactaag gcatctcctg
    10201 ttattaatga tttactttct ttatgataaa tggatatatg tccaggcatg tgcccaggtg
    10261 tagctaggat tccaattcct ccacaacaat cgaaataatc cctatctttt aactttatat
    10321 caacgttaca actttctata gattgaagca ttttatgaaa atgatctgct tctactttct
    10381 cattttctga taatgaatca tatatatttt cagcttgttg taatcttaat gattttttac
    10441 ttccatcaat atatggagca tcttcttctg atgctaatac ttttacttta ggatattttc
    10501 ttttaaattc tgctaaagct cccatatggt cataatcatg atgtgtaata attattttag
    10561 ataaatcctt tacattaata tttttagcta atgcagcttc ttctattaag ctcaaaaaat
    10621 ttggatatcc acagtcaatt aatatcattt cattctcatc ttccaatata actggatgta
    10681 tagcatcact ttgtcctgaa aaatcgaaag atatatctaa tacatttatt ttactcattt
    10741 taagtcctcc tagtaaaatt tcaattatag aaaataatat catgttcaaa aacaa
//
