LOCUS       NZ_CP014170.1          10237 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP014170.1 Clostridium tyrobutyricum strain KCTC 5387 chromosome,
            complete genome.
ACCESSION   NZ_CP014170
VERSION     NZ_CP014170.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:50:31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2223237
            Orig. end    :: 2233474
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10237
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2228237:2228474](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5237)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10237
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10237
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(913..1716)
                     /locus_tag="ctg1_2177"
                     /transl_table=11
                     /translation="MNNLIMAFLLTLFAGLSTGIGSTLAFFTRKTNTRFLAVSLGFSAG
                     VMIYVSMIEIFFKAKDSLIGELGIKMGSWVTVFSFFAGMILIAIIDKIIPSYENPHELR
                     KIEDIDENKNNPDINLLRMGTFTALAIAIHNFPEGLATFTAALKEPTIAIPIGVAIAIH
                     NIPEGIAVSVPVYFATGNRKKAFIYSFLSGLSEPLGALIGYLILMPFISDLTFGILFAA
                     VAGIMVFISIDELLPSAQKYGEHHLSIYGLMVGMAVMAVSLLLFI"
     PFAM_domain     complement(934..1389)
                     /aSDomain="Zip"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02535.24"
                     /description="ZIP Zinc transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2177_0082"
                     /evalue="4.00E-26"
                     /label="ctg1_2177"
                     /locus_tag="ctg1_2177"
                     /protein_end="261"
                     /protein_start="109"
                     /score="92.1"
                     /tool="antismash"
                     /translation="DENKNNPDINLLRMGTFTALAIAIHNFPEGLATFTAALKEPTIAI
                     PIGVAIAIHNIPEGIAVSVPVYFATGNRKKAFIYSFLSGLSEPLGALIGYLILMPFISD
                     LTFGILFAAVAGIMVFISIDELLPSAQKYGEHHLSIYGLMVGMAVMAV"
     CDS             complement(1738..2154)
                     /locus_tag="ctg1_2178"
                     /transl_table=11
                     /translation="MNRLKNIVDIKTLKFLIVGIINTLVGTFIMFSFYNLLGLNYWISS
                     SANYILASILSYILNKYWTFQNREKSVKIVVKFIVNILVCYLISYGVAKPLVRSFLSAA
                     GTKIQDNVSMFVGMILFTSLNYFGQRFFAFKEQD"
     PFAM_domain     complement(1753..2115)
                     /aSDomain="GtrA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04138.16"
                     /description="GtrA-like protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2178_0083"
                     /evalue="1.70E-22"
                     /label="ctg1_2178"
                     /locus_tag="ctg1_2178"
                     /protein_end="134"
                     /protein_start="13"
                     /score="79.9"
                     /tool="antismash"
                     /translation="KFLIVGIINTLVGTFIMFSFYNLLGLNYWISSSANYILASILSYI
                     LNKYWTFQNREKSVKIVVKFIVNILVCYLISYGVAKPLVRSFLSAAGTKIQDNVSMFVG
                     MILFTSLNYFGQRFFAF"
     CDS             complement(2155..3126)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 190.7; E-value: 7e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2179"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-31,
                     bitscore: 107.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQQDSISIVVPCYNEEEAIPIFYGEIVKKLNTIPNIDYEIIYIN
                     DGSRDKSAKEMKQLAIQDDRVKYILLSRNFGKEAAMYAGLKESKGDYIAIMDVDLQDPP
                     VLLKEMYETLKSGYYDSVATRRVTRKGEPPIRSLFARLYYKLINKLSKTQIVDGARDFR
                     LMKRQMVDAVLSITEYNRFTKGIFSWVGFETKWLEYENIERVAGETKWSFWKLFLYSIE
                     SIVAFSTAPLALASVLGIILFGIAIVFIVLIIVRTLYFGDSTSGWPSLVCVILLTSGIQ
                     LLCIGVIGEYLAKTYLEAKHRPLYIIKEKNTDQKKNSEAENS"
     PFAM_domain     complement(2611..3105)
                     /aSDomain="Glycos_transf_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00535.28"
                     /description="Glycosyl transferase family 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2179_0084"
                     /evalue="2.30E-33"
                     /label="ctg1_2179"
                     /locus_tag="ctg1_2179"
                     /protein_end="172"
                     /protein_start="7"
                     /score="115.5"
                     /tool="antismash"
                     /translation="SIVVPCYNEEEAIPIFYGEIVKKLNTIPNIDYEIIYINDGSRDKS
                     AKEMKQLAIQDDRVKYILLSRNFGKEAAMYAGLKESKGDYIAIMDVDLQDPPVLLKEMY
                     ETLKSGYYDSVATRRVTRKGEPPIRSLFARLYYKLINKLSKTQIVDGARDFRLMKRQMV
                     DA"
     CDS             complement(3147..4802)
                     /locus_tag="ctg1_2180"
                     /transl_table=11
                     /translation="MKDKNKIYNSLVINTSIAIFFIILSVVSLYFSHIYNFRMVTGDDY
                     QFHAVRIEGLYEALRSHVYFPRINMTFMHSMGYATSIFYSDVYLYFPAVLRLLGFSLAE
                     SYVIFLVFVNFLTFVISYFSMMNIEKKISKSLIFSLLYTLSFYRLFDLTGRAALGETLA
                     MSFLPLAFMGLYHILYKNKNKWYFMTIGISLIIYAHMLSTIMFGLAVFVFLLINIKKLY
                     YDRERLKCFIKSVLVIILLVAFSLVPILEQMHSQKFVVTILVFHVSKYAKNLGGLVTDS
                     LSNTPLTSNLGVVLLIFLIIYLFSIRKLKNRSTRDIFIVGLIFLLLTTSLFPWKIAERT
                     FLHTIQFPWRFISIVTLCLCWIIAEDSLKLLKSKRITSVLLFLVILLSVSYSINCSERS
                     RKVFKYTQLDHINTDYIGGAEYLPEKAHYTTLKNTKLDLLYNKKDIDIKNYTKNRDTII
                     FDFKTTNRQSVTLPLIYYKGYVSQLTGRGTVSEPFLNRGQEAGLISVIVKGEGRVKVYY
                     RETVLQAASKYVSLASWIIFLFYLLVIRKKTDSN"
     PFAM_domain     complement(3621..4505)
                     /aSDomain="YfhO"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09586.12"
                     /description="Bacterial membrane protein YfhO"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2180_0085"
                     /evalue="1.30E-11"
                     /label="ctg1_2180"
                     /locus_tag="ctg1_2180"
                     /protein_end="394"
                     /protein_start="99"
                     /score="43.7"
                     /tool="antismash"
                     /translation="FSLAESYVIFLVFVNFLTFVISYFSMMNIEKKISKSLIFSLLYTL
                     SFYRLFDLTGRAALGETLAMSFLPLAFMGLYHILYKNKNKWYFMTIGISLIIYAHMLST
                     IMFGLAVFVFLLINIKKLYYDRERLKCFIKSVLVIILLVAFSLVPILEQMHSQKFVVTI
                     LVFHVSKYAKNLGGLVTDSLSNTPLTSNLGVVLLIFLIIYLFSIRKLKNRSTRDIFIVG
                     LIFLLLTTSLFPWKIAERTFLHTIQFPWRFISIVTLCLCWIIAEDSLKLLKSKRITSVL
                     LFLVILLSVSYSIN"
     CDS             complement(5001..5237)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2181"
                     /sec_met_domain="Linocin_M18 (E-value: 3.5e-15, bitscore:
                     53.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VLESDRISKMLDKNVFTSHVLGTNQGALLCTEPNYIDIVIGQDIE
                     TAYIELKNLNHVLRILETVFLKIKNRKSIVVFE"
     PFAM_domain     complement(5046..5234)
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2181_0086"
                     /evalue="3.10E-12"
                     /label="ctg1_2181"
                     /locus_tag="ctg1_2181"
                     /protein_end="64"
                     /protein_start="1"
                     /score="46.5"
                     /tool="antismash"
                     /translation="LESDRISKMLDKNVFTSHVLGTNQGALLCTEPNYIDIVIGQDIET
                     AYIELKNLNHVLRILETV"
     CDS             5599..6561
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:diguanylate cyclase (Score: 162.8; E-value:
                     2.9e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2182"
                     /transl_table=11
                     /translation="MNNNDDTESTKTYHIDIPDNLIKEWQSIVDLIARIARVRAALIMR
                     VQNGEIEVFIASNTKNNPYKLGNKENLIDSGLYCETVIKKGKMLLVPNASKSDKWRNNP
                     DMKYNMVCYLGFPIRLPNGDFFGTICMLDDKENNFSQDMKDFMEKMRNLIESYLNLLHL
                     SITDQLTGLYNRTYLDIKASKEIKKANFNQKTITALLLDIDHFKKINDTFGHQIGDEVL
                     KNFAEIMTSFLRNRDITFRLGGDEFIVLMPDTSINDAVMEADNLRLKVEGIQIRPDLKI
                     TISIGAAEWKCGESLDSWFMRVDKALYKGKHAGGNRVMS"
     PFAM_domain     5674..6048
                     /aSDomain="GAF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01590.28"
                     /description="GAF domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2182_0087"
                     /evalue="9.90E-05"
                     /label="ctg1_2182"
                     /locus_tag="ctg1_2182"
                     /protein_end="150"
                     /protein_start="25"
                     /score="23.1"
                     /tool="antismash"
                     /translation="QSIVDLIARIARVRAALIMRVQNGEIEVFIASNTKNNPYKLGNKE
                     NLIDSGLYCETVIKKGKMLLVPNASKSDKWRNNPDMKYNMVCYLGFPIRLPNGDFFGTI
                     CMLDDKENNFSQDMKDFMEKM"
     aSDomain        6082..6555
                     /aSDomain="TIGR00254"
                     /aSTool="tigrfam"
                     /description="GGDEF: diguanylate cyclase (GGDEF) domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2182_0042"
                     /evalue="3.50E-49"
                     /identifier="TIGR00254"
                     /label="ctg1_2182"
                     /locus_tag="ctg1_2182"
                     /protein_end="319"
                     /protein_start="161"
                     /score="164.7"
                     /tool="antismash"
                     /translation="HLSITDQLTGLYNRTYLDIKASKEIKKANFNQKTITALLLDIDHF
                     KKINDTFGHQIGDEVLKNFAEIMTSFLRNRDITFRLGGDEFIVLMPDTSINDAVMEADN
                     LRLKVEGIQIRPDLKITISIGAAEWKCGESLDSWFMRVDKALYKGKHAGGNRVM"
     PFAM_domain     6091..6549
                     /aSDomain="GGDEF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00990.23"
                     /description="Diguanylate cyclase, GGDEF domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2182_0088"
                     /evalue="1.60E-42"
                     /label="ctg1_2182"
                     /locus_tag="ctg1_2182"
                     /protein_end="317"
                     /protein_start="164"
                     /score="145.1"
                     /tool="antismash"
                     /translation="ITDQLTGLYNRTYLDIKASKEIKKANFNQKTITALLLDIDHFKKI
                     NDTFGHQIGDEVLKNFAEIMTSFLRNRDITFRLGGDEFIVLMPDTSINDAVMEADNLRL
                     KVEGIQIRPDLKITISIGAAEWKCGESLDSWFMRVDKALYKGKHAGGNR"
     CDS             complement(6680..6922)
                     /locus_tag="ctg1_2183"
                     /transl_table=11
                     /translation="MLFPFYNLWDNYWRQYRINAETAIQTALQRVPGQVIRVEVDTEDG
                     LLVYEIYIRTTSGIIYEVTIDANTGEILEVDRQND"
     PFAM_domain     complement(6698..6871)
                     /aSDomain="PepSY"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03413.21"
                     /description="Peptidase propeptide and YPEB domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2183_0089"
                     /evalue="1.70E-14"
                     /label="ctg1_2183"
                     /locus_tag="ctg1_2183"
                     /protein_end="75"
                     /protein_start="17"
                     /score="54.2"
                     /tool="antismash"
                     /translation="INAETAIQTALQRVPGQVIRVEVDTEDGLLVYEIYIRTTSGIIYE
                     VTIDANTGEILEV"
     CDS             7567..7749
                     /locus_tag="ctg1_2184"
                     /transl_table=11
                     /translation="LSRKNRILVPEARQGLEKLKIEAAEELAKNNKNQDSSHQVFSIGG
                     QMVKKMVESYEKKLK"
     PFAM_domain     7579..7743
                     /aSDomain="SASP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00269.22"
                     /description="Small, acid-soluble spore proteins,
                     alpha/beta type"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2184_0090"
                     /evalue="1.50E-18"
                     /label="ctg1_2184"
                     /locus_tag="ctg1_2184"
                     /protein_end="59"
                     /protein_start="4"
                     /score="66.6"
                     /tool="antismash"
                     /translation="NRILVPEARQGLEKLKIEAAEELAKNNKNQDSSHQVFSIGGQMVK
                     KMVESYEKKL"
     CDS             complement(8538..9035)
                     /locus_tag="ctg1_2185"
                     /transl_table=11
                     /translation="MFKVPQVLSRGFSEKENSRIKSNLLKGCSIIEYNCFSDLISYNKH
                     GSFVFGGSSGYEAFNKDNGTPTTSSITASCICRGIMKYFPMLKDVKIVRTWAGWIDECK
                     DLTPVISFVDEVPDFILACAFTGHGFGISPTVGMLLSEMVEGKETTLDINAFRYDRFKA
                     KI"
     PFAM_domain     complement(8607..8927)
                     /aSDomain="DAO"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01266.26"
                     /description="FAD dependent oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2185_0091"
                     /evalue="1.80E-12"
                     /label="ctg1_2185"
                     /locus_tag="ctg1_2185"
                     /protein_end="143"
                     /protein_start="36"
                     /score="47.6"
                     /tool="antismash"
                     /translation="SDLISYNKHGSFVFGGSSGYEAFNKDNGTPTTSSITASCICRGIM
                     KYFPMLKDVKIVRTWAGWIDECKDLTPVISFVDEVPDFILACAFTGHGFGISPTVGMLL
                     SEM"
     CDS             9144..9671
                     /locus_tag="ctg1_2186"
                     /transl_table=11
                     /translation="MFVNPCQPPSYPMPLYQSLRGKYFVGLSREEFGEGRYAWAGLFNP
                     RDSGVLLFVNVFTVSNVTEIPFSFQVWLNTTASGKAKLTDMQSPSNTAIRPLPKPRIKF
                     LYSENVDAEPTGGTIIFGRRCPAETTIVSEEDGKFICRPGGNFLINCLPPETNNEKILG
                     RIAFGWWEESCI"
     PFAM_domain     9171..9662
                     /aSDomain="DUF6143"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19640.1"
                     /description="Family of unknown function (DUF6143)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2186_0092"
                     /evalue="1.10E-49"
                     /label="ctg1_2186"
                     /locus_tag="ctg1_2186"
                     /protein_end="173"
                     /protein_start="9"
                     /score="168.9"
                     /tool="antismash"
                     /translation="SYPMPLYQSLRGKYFVGLSREEFGEGRYAWAGLFNPRDSGVLLFV
                     NVFTVSNVTEIPFSFQVWLNTTASGKAKLTDMQSPSNTAIRPLPKPRIKFLYSENVDAE
                     PTGGTIIFGRRCPAETTIVSEEDGKFICRPGGNFLINCLPPETNNEKILGRIAFGWWEE
                     S"
ORIGIN
        1 catatacagc tggatcctga ttattagttc ttcctgactt acatgtcagt ttacaaatat
       61 ttttcatttc tacatcagac aattcaaaat caaatatatt taaattgtca ctctggtgct
      121 gctttgaagt tgcctttgga atcggaattg ctccaagctg tatgtgccag cgtaaaataa
      181 tttgtgaaat tgtcttctta tgcactttgg ctatttcacc aattctttcc tccttaagta
      241 tactgttagc tcttccaagg ggactccatg attgtgttac aatattatgt tctttattcc
      301 atttacgctg tttttcctga ttaaaatatg gatgaagctc tatctggttt atacttggtg
      361 tcacacctgt ttcctttatt aacctttcta tatgttcagg caggaagtta cagaccccta
      421 ttgatcttat gaaacctctc ttttttgact ctatcaaagc ctgccatgct tcaacataca
      481 aatcaaccct tggatttggc cagtgaatca ggtataaatc ataataatca agtcccgctc
      541 taaaaagtga ctcctgaaca gttacaattg cctctttata tgaatgatga cgtcctggca
      601 attttgaagt gattaaaagt tcatctcgcg atacaggact ctgtttaaca gcttgaccta
      661 ctgctccctc attttcatag ttgaatgcag aatcaattaa tctatatcca atgtcaattg
      721 cctcttttat ggcatttgct ccatccatac catttaactt ataggttccg aaaccaatag
      781 aaggtactct aagtccatca tttaattcta tttccataac tttatcctgc atagtaaaca
      841 ctctccctgt ttttatcata attttacaga tattatactt cttttaatag gaaaagtcac
      901 taattaaaat agttaaataa acaacaataa acttacagcc ataactgcca tcccaaccat
      961 taatccatat atagatagat ggtgttctcc atatttttga gcagatggaa gtaattcatc
     1021 tatggatata aataccatta tgccagccac tgctgcaaag agtatgccaa atgttaaatc
     1081 acttatgaaa ggcattaata tcagatagcc aataagtgcg cctaatggtt ccgacaatcc
     1141 agatagaaag gaatatataa atgctttttt tctgtttcct gtagcaaaat atactggtac
     1201 agacactgct attccttcag gtatattgtg aattgctatg gcaactccaa ttgggatagc
     1261 tattgttggt tccttcagtg ctgcagtaaa ggtagccaat ccttctggaa aattatgaat
     1321 tgctatggcc aatgctgtaa atgttcccat tctcaataaa ttaatgtcag gattattttt
     1381 attttcatct atatcttcta ttttacgaag ttcatgagga ttttcatagc tcggaataat
     1441 tttatcaatt attgcgatta aaatcatacc tgcaaaaaat gaaaatacag taacccatga
     1501 acccatttta attcccaatt cacctataag ggaatcttta gctttaaaga atatttcaat
     1561 catagataca tatatcatta cacctgcaga aaatccgaga cttactgcta aaaaccttgt
     1621 attggttttt ctagtaaaaa aagctaaggt actgccaatt cccgtagata ggcccgcaaa
     1681 aagagttaat aaaaatgcca taatcaaatt attcatatca aacctccgaa acgtccacta
     1741 atcctgctcc ttaaaagcaa aaaatctttg tccaaaatag ttgagtgaag taaataatat
     1801 catgcctaca aacatagata cattatcttg tattttagta cccgctgcac ttaaaaaact
     1861 cctaactaac ggttttgcaa ctccatatga gattaaatag cataccaaaa tgttaacaat
     1921 aaatttaacc actatcttaa ctgacttttc tctattctga aatgtccagt atttattgag
     1981 aatatagctt aatatactag ccaatatata atttgctgat gatgaaatcc agtagttcaa
     2041 tcctaataaa ttataaaagc tgaacataat aaatgtacca actaaagtgt tgattatacc
     2101 aactattaga aatttaagcg ttttaatatc aactatattt tttaatctat tcatctagct
     2161 attctccgct tcagaatttt tcttttgatc tgtattcttt tcctttatta tataaagagg
     2221 tctatgcttc gcttctaaat atgtcttggc taaatactca ccaataaccc ctatacataa
     2281 taactgaatt ccacttgtca agagaattac acagaccaac gacggccatc cactggtgga
     2341 atctccaaaa tataaagttc taacaataat caatacaata aaaacaatag caatgccaaa
     2401 taaaataata cctaaaacag aagccaatgc taatggagca gttgaaaaag ccactatgct
     2461 ctcaatagaa tacaaaaaca atttccaaaa agaccattta gtttctccag ctacacgttc
     2521 aatattttca tattccagcc attttgtttc aaaaccaacc cagctaaaaa tacctttggt
     2581 aaaacggtta tattctgtaa tagacagtac agcatcaacc atttgtctct tcattagtct
     2641 aaaatctcta gcaccatcta ctatttgagt ttttgatagt ttattaatca atttataata
     2701 taatcgtgca aacaaacttc taataggtgg ttcacctttc cttgtaacac gcctggtagc
     2761 tacagaatca taatatccac tctttaaagt ttcatacatt tcctttaaca aaacaggtgg
     2821 atcttgtaaa tccacatcca taattgcaat ataatctcct ttactttcct taagtccagc
     2881 atacatagct gcttccttac caaaatttct tgataataaa atatatttga cacgatcatc
     2941 ttgaattgcc aactgtttca tttcctttgc agacttatct ctgctaccat catttatata
     3001 tataatttca taatctatat tgggtattgt attcagtttt tttactattt caccataaaa
     3061 tattggaatt gcctcttcct cgttataaca tggcactaca atagatatac tatcctgttg
     3121 tttcatttta tactccttat atatttttaa tttgaatcag ttttctttct tataactaga
     3181 agatagaaca aaaatataat ccagctagct aaagatacat attttgatgc tgcttgcaga
     3241 acagtttctc tataataaac ctttaccctt ccttcgcctt ttacaattac agaaattaat
     3301 cctgcctctt gtcctctatt taaaaatggt tcactaactg ttcctcttcc tgtcagttgt
     3361 gaaacatacc ctttataata tattaatgga agtgtaacac tttgacgatt agttgtttta
     3421 aaatcaaaaa taatcgtatc tctattttta gtataatttt ttatgtctat atctttttta
     3481 ttgtatagta aatccagttt tgtattcttc aaagttgtgt aatgtgcttt ttctggcaag
     3541 tactcggctc ctccaatata gtcggtattt atatggtcga gctgggtata tttaaaaact
     3601 ttacgtgagc gttcagaaca atttatagaa tatgatacag aaagtaaaat aaccagaaat
     3661 agtaatacac tggttattct tttacttttt aaaagcttca aactatcctc tgcaataatc
     3721 cagcacaagc ataatgtaac aattgaaata aatctccatg gaaattgtat ggtatgcaaa
     3781 aatgtccttt cagctatttt ccagggaaat aaactagttg tcaacaataa aaatattaat
     3841 ccaacaataa atatgtctct agtgcttcta ttttttagtt tcctaattga aaataaataa
     3901 ataattaaaa atatcaataa tacaacaccc aggttagaag ttaaaggtgt atttgacagt
     3961 gaatcagtaa ctagtccccc taagtttttg gcatatttcg acacatgaaa aactaatatt
     4021 gttaccacaa atttttgaga atgcatctgc tctaaaatag ggacaagact aaatgcaact
     4081 aagagtatta ttactaaaac tgatttgata aagcacttca atcgttccct atcatagtaa
     4141 agttttttaa tattaataag caaaaaaaca aaaacagcaa gtccaaacat gattgttgac
     4201 agcatatgag cataaataat caacgaaatt cctattgtca tgaaatacca tttattctta
     4261 tttttataga gaatatgata taaccccata aaagccaaag gaagaaatga catagctaaa
     4321 gtttctccta aagccgccct gccagttaaa tcaaaaaggc gataaaaaga tagtgtataa
     4381 agcagtgaaa atatcaagct tttacttatc tttttctcaa tattcatcat agaaaaatac
     4441 gatataacaa aagttaaaaa attaacgaaa acaaggaaaa tcacatagga ttcagctaat
     4501 gaaaatccta ataatcttaa aactgcagga aaatacaaat atacatcaga ataaaatatg
     4561 cttgtggcat agcccattga atgcatgaat gtcatgttta ttctagggaa atagacatga
     4621 cttcttaaag cttcatataa tccttctatc ctaactgcat gaaattggta atcgtcgccg
     4681 gtaaccattc taaaattata aatgtgagaa aaatataaag atactacact taaaattata
     4741 aaaaatattg caatgcttgt attaatcacc agcgaattgt atattttatt tttatctttc
     4801 ataagaaact cctataaagt attttttaac aaaaaattta cacaaagtaa ttatattctt
     4861 agcaatttct actgtcaaca tattcgacat tatgctacaa attcatttaa aaactttaca
     4921 aagaacttta ttaataaatt taagccatta aaaagaagtg aattatattg caaattcacc
     4981 tcttggatgt acaaactgaa tcattcaaaa actactattg atttcctgtt tttaattttt
     5041 aaaaatactg tttccaaaat tcttaaaaca tgatttaaat tcttgagttc aatatatgcc
     5101 gtttctatat cctgtcctat tacaatatct atataattcg gttcagtaca caaaagtgct
     5161 ccttggtttg taccaagtac atgactggta aatacgtttt tatccagcat cttactaatt
     5221 ctatcacttt caagcactct cgctcctggt tgtatacgct gcatatgtat catatgtttt
     5281 tctttgttac agctattata tcgcatgtga ttaaaaatta aatgcagcag ataacttata
     5341 cattttttaa taacatgata taatcaaata attatagaag atgtattcaa ttacgccgta
     5401 atacctatag cgcaaaaaag ccaaagctaa attttggaaa aatgaatgta gtttgtcagg
     5461 tatgtagtat aattatatat aaaagtactt ctataatatt caaaatataa aatcagagat
     5521 gtaaataatt tttcatttta aataggttta ccaattttat aatttaactt ttctaattat
     5581 ataaaggtgg ttaaagcaat gaataataat gatgatacag agtcaactaa aacttatcat
     5641 attgatattc cagataacct gattaaagaa tggcagagta tagtggatct catagcccgt
     5701 attgcaagag tccgtgcagc tcttatcatg agagtacaga acggagaaat tgaagtattt
     5761 atagccagca atactaaaaa taatccttat aaattgggaa acaaggaaaa tctcatagac
     5821 tcgggacttt attgcgaaac agttatcaaa aaaggtaaaa tgctgctagt acccaatgca
     5881 tcaaaatcgg ataagtggcg aaataatcct gatatgaaat acaatatggt gtgttattta
     5941 ggatttccaa tcagattgcc taatggagat ttttttggaa caatttgtat gcttgatgac
     6001 aaggaaaata acttttcaca ggatatgaaa gattttatgg aaaaaatgcg aaacttaatt
     6061 gagtcttatt taaatttatt gcacttaagt atcactgatc agctaacagg cttatataat
     6121 cgtacttacc tcgatataaa agcatctaaa gaaattaaaa aggcaaactt caaccaaaag
     6181 actattacag cacttttatt ggatatagat cactttaaga aaatcaatga tacctttgga
     6241 catcaaatcg gtgatgaggt gcttaagaat tttgctgaaa ttatgacttc ttttttaaga
     6301 aatagagata taacttttag attgggtgga gatgaattta tcgtattaat gccagataca
     6361 tctattaatg atgcagtaat ggaggcagac aatttacgtt taaaagtaga aggaattcaa
     6421 atacgacctg accttaaaat aacaataagc attggagctg cagaatggaa atgcggtgaa
     6481 tctttagata gctggtttat gagggtggac aaggctctat acaagggtaa acacgctgga
     6541 ggcaatcgag ttatgtcata aaatattgct aactaaatta taatactagt gatacgttca
     6601 ccgttgggag taaaagtcat gacacaagta tcattggttt tgttttggat taaaatgagc
     6661 cctggtaagg gctctcaaat taatcatttt gcctatctac ttcaagtatc tctccagtat
     6721 tagcatctat tgtaacttca tatattatcc cactagtagt tctaatgtaa atttcgtaaa
     6781 ctaataaacc atcttcagtg tccacttcaa ctcttattac ttgccctggc accctttgta
     6841 atgcagtttg tatagctgtt tcagcattaa tacgatactg tctccagtaa ttatcccata
     6901 aattataaaa aggaaataac attattcact catctttcat tttattattc gccttattat
     6961 tatattcaag taaagaatat tagtgaattt tatatattat tctaaaacat gttcactttc
     7021 tttgttttaa tatctacctt attttcaatt ttatctattc tctttttaat tacaccttat
     7081 atttctccaa attactatat ttcaaagata gctttaatct ctctagttaa gttaactctt
     7141 tcataatttc aattccttac atgcataata attctaattc tataaatttt ataaatattt
     7201 ttccacatat ttgttttaca tatttccaat attctcctcc tagtgttttt tatataatat
     7261 ataaagtttc cagtataata tatctaattt ctgtacattc tatttcatat aaggttatta
     7321 atatattgaa tctattaata ttcaatgttt actcaaactt aaatattatg ctgaagtata
     7381 ttgatagtta cctttatact ggggatgatc aatctccagt gttttaataa tcatagttct
     7441 cctataacca ttgctatgcc aggatttcac tcctggcttt ttttatttta tttgataact
     7501 attcctttac agctcttgta tatgattatt ttaaatacat aaaataatcg aaaggagatg
     7561 attattttgt ctagaaaaaa tagaatatta gtgcccgaag ctcgacaagg tcttgaaaaa
     7621 ttgaaaatcg aagctgcaga agaattagct aaaaataata aaaatcagga ttcctcacat
     7681 caagtttttt ctataggcgg ccagatggta aaaaaaatgg ttgaaagcta tgaaaaaaag
     7741 ttaaaatagt tacttttgta tcacacaagc tcatctcttg tgtgattttt aattttattc
     7801 cttgtattca aaaatatttt atattgtaat tcaatgaaaa tgattctctt aaatttactg
     7861 tttatatttt ccaacttttg ctttcaaaac tcaaccatca acatcttaat acctccaatc
     7921 aatcagctaa tattagtata aaagtgtaaa cataaaggaa tagacttata gaattaataa
     7981 aataaaaata tagaaaacat ttaggatgcc tttttaaaag taatatttga gatattttta
     8041 ttgaagtctt ctgatattct acatcttaca acaagatata ctatacctaa tcccatccat
     8101 gtaaatccca caatttttga aatattagaa agtcctaata atatatatat atacacacac
     8161 attccaagca atggtacaac tagtagaatt ttaaaacctg ttatttttta catttcagtt
     8221 agtaacattt cctttttcct atatttaatt tttaattatt ctcatgtcta ttatcagata
     8281 aaaaagatag ctaatatgct atctttttta gtttacactt gatcttagat tagacccaac
     8341 tattgcatcc atctctatct ctattaattg tgtatgacgg ttgagcatag gagttccaac
     8401 aattgtacaa agaggtttga tatcatgaaa aatttttgaa taagctttac caatttttca
     8461 agaatgtatt ttgtctgctt gtaagcactt ccttctccat aaactgtacc atccggctgt
     8521 acagctgtag ttcctcttta tatttttgct ttaaatctat cataacggaa agcatttata
     8581 tcaagagtag tttcttttcc ttctaccatt tctgataaaa gcataccaac agttggcgaa
     8641 attccaaatc cgtgcccagt aaaagcacat gcaagtataa aatcgggtac ttcatctaca
     8701 aaacttataa ctggtgtgag atctttacac tcatcaatcc agcctgccca ggtacgaaca
     8761 atttttacat cctttaacat gggaaagtat ttcattattc ctctgcatat acatgatgcc
     8821 gtaatacttg aagttgtagg tgttccatta tctttattaa aagcttcata acccgatgaa
     8881 ccgccaaata caaaagaacc atgcttatta tatgaaatta aatccgaaaa acaattgtac
     8941 tctattatgc tgcagccttt tagtaaatta cttttaattc tactattttc tttttctgaa
     9001 aatccacgac ttaacacctg tggtacctta aacattaaat cgcacgaaga aaaattaaag
     9061 ttctgaattc aaagcaaaag tggaaacttg atttcacttt ttccaaacat ctttcatata
     9121 atacagtaga aagggtgata tttatgttcg ttaatccatg tcagccacca tcctatccaa
     9181 tgcctttata tcaatccctt cggggcaagt atttcgttgg gttaagccga gaagaattcg
     9241 gcgaaggcag atatgcgtgg gccggacttt tcaatccccg cgattccgga gtattacttt
     9301 tcgtaaatgt ttttaccgtt agtaatgtta ctgaaattcc attttctttt caggtctggc
     9361 tgaatacaac agcatcagga aaggcaaagc tgacggatat gcaaagccca tcaaacacag
     9421 caatccgacc tctgccgaaa ccgagaatta agtttttgta ttcagaaaac gtcgatgcgg
     9481 aacctacggg tggaacaatc atatttggac gccgttgtcc tgctgaaacg actattgtgt
     9541 cggaagaaga cgggaaattc atttgccggc ctggaggtaa ttttttaata aactgtcttc
     9601 caccagaaac aaacaacgaa aaaattcttg gacgtatcgc atttggatgg tgggaggaat
     9661 cttgcatata attcccgaat gattttcaga ctggagccca acgcaatttc aaccgcgaca
     9721 ttcattttat tttagtgaca tcagtaccat cgtactgtgc ttcgcagcat tgccgataat
     9781 tgtcactaaa ataatactaa atataagtgt taaaagaacc aagcgactta taaataatca
     9841 ccgtttaatt cttcagttat atagcagctt acagcgttac ttaatactcc aaggccgctg
     9901 ttgtcaaagt tgcctttggc actcttttta tcacaaacac atataatttt atcaactcaa
     9961 atgtaaactc caaaccatag gtactgtgtg aaaacacaac cgcctttttg gcggcaaact
    10021 gaattactta ttctgctttt tacatttgat tggaagtttt tcagaccacg agagaaaatc
    10081 tttcagaaaa tcaagatcag tatcttacat gtgctttgga atttctgtaa gaaggaattc
    10141 aaagtaattg tatgatttta agttattaga cttagcagtc tctgcaatac tgtaaattat
    10201 tgcactgacc ttagcaccgt caatcgtatc gattaga
//
