Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
2.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP084662.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | ranthipeptide | 799,813 | 819,970 |
Region 1.2 | NRPS | 1,644,041 | 1,696,486 | equibactin | NRP | 14%
Region 1.3 | ranthipeptide | 2,749,000 | 2,770,361 |
Region 1.4 | cyclic-lactone-autoinducer,RRE-containing | 3,177,691 | 3,201,604 |
Region 1.5 | LAP | 3,650,602 | 3,674,361 | clostridiolysin S | RiPP:LAP | 88%
Region 1.6 | cyclic-lactone-autoinducer | 3,839,416 | 3,866,959 |
Region 1.7 | RiPP-like | 4,069,715 | 4,081,919 |

NZ_CP084663.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | lanthipeptide-class-ii | 26,999 | 45,443 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | ranthipeptide | 799,813 | 819,970 |
Region 1.2 | NRPS | 1,644,041 | 1,696,486 | equibactin | NRP | 14%
Region 1.3 | ranthipeptide | 2,749,000 | 2,770,361 |
Region 1.4 | cyclic-lactone-autoinducer,RRE-containing | 3,177,691 | 3,201,604 |
Region 1.5 | LAP | 3,650,602 | 3,674,361 | clostridiolysin S | RiPP:LAP | 88%
Region 1.6 | cyclic-lactone-autoinducer | 3,839,416 | 3,866,959 |
Region 1.7 | RiPP-like | 4,069,715 | 4,081,919 |
Region 2.1 | lanthipeptide-class-ii | 26,999 | 45,443 |

Compact view
NZ_CP084662.1 - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 799,813 - 819,970 nt. (total: 20,158 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000599.1 |  | 0.17 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001387.1 |  | 0.17 | Other | nucleocidin | Streptomyces calvus
BGC0001887.1 |  | 0.13 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000608.1 |  | 0.12 | RiPP | nocathiacin | Actinokineospora fastidiosa
BGC0000684.1 |  | 0.11 | Terpene | asperthecin | Aspergillus nidulans FGSC A4
BGC0001860.1 |  | 0.10 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.10 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0001298.1 |  | 0.10 | Polyketide | 4-Z-annimycin | Streptomyces calvus
BGC0001591.1 |  | 0.09 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.09 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000599.1 |  | 0.48 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001387.1 |  | 0.48 | Other | nucleocidin | Streptomyces calvus
BGC0001887.1 |  | 0.41 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000608.1 |  | 0.39 | RiPP | nocathiacin | Actinokineospora fastidiosa
BGC0000684.1 |  | 0.37 | Terpene | asperthecin | Aspergillus nidulans FGSC A4
BGC0001860.1 |  | 0.35 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.35 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0001298.1 |  | 0.35 | Polyketide | 4-Z-annimycin | Streptomyces calvus
BGC0001591.1 |  | 0.32 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.32 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP084662.1 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,644,041 - 1,696,486 nt. (total: 52,446 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000343.1 |  | 0.26 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000412.1 |  | 0.26 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0001444.1 |  | 0.23 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.23 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000347.1 |  | 0.23 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0001591.1 |  | 0.21 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.21 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000410.1 |  | 0.21 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001343.1 |  | 0.21 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001261.1 |  | 0.21 | NRP | AM-toxin | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000343.1 |  | 0.60 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000412.1 |  | 0.60 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0001444.1 |  | 0.57 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.57 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000347.1 |  | 0.56 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0001591.1 |  | 0.54 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.54 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000410.1 |  | 0.54 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001343.1 |  | 0.54 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001261.1 |  | 0.53 | NRP | AM-toxin | Alternaria alternata

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 1644040 - 1696486:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys - cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1564: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (29..435): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPgQGiiCK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      70% (weak)
ctg1_1566: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (564..947): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLgLIhK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (1922..2304): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_1567: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (541..920): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNwSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)

NZ_CP084662.1 - Region 3 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,749,000 - 2,770,361 nt. (total: 21,362 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.18 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000758.1 |  | 0.14 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0001860.1 |  | 0.09 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.08 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000340.1 |  | 0.08 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0000433.1 |  | 0.07 | NRP | surfactin | Bacillus velezensis FZB42
BGC0001179.1 |  | 0.06 | Polyketide | rishirilide B, rishirilide A | Streptomyces bottropensis
BGC0001195.1 |  | 0.06 | NRP, Polyketide | nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D | Nocardiopsis sp. CMB-M0232
BGC0001719.1 |  | 0.06 | Polyketide | olimycin A, olimycin B | Streptomyces olivaceus
BGC0001523.1 |  | 0.04 | Polyketide | azalomycin F3a | Streptomyces sp. 211726

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.50 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000758.1 |  | 0.44 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0001860.1 |  | 0.32 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.32 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000340.1 |  | 0.30 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0000433.1 |  | 0.29 | NRP | surfactin | Bacillus velezensis FZB42
BGC0001179.1 |  | 0.27 | Polyketide | rishirilide B, rishirilide A | Streptomyces bottropensis
BGC0001195.1 |  | 0.27 | NRP, Polyketide | nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D | Nocardiopsis sp. CMB-M0232
BGC0001719.1 |  | 0.25 | Polyketide | olimycin A, olimycin B | Streptomyces olivaceus
BGC0001523.1 |  | 0.21 | Polyketide | azalomycin F3a | Streptomyces sp. 211726

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP084662.1 - Region 4 - RRE-containing,cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,177,691 - 3,201,604 nt. (total: 23,914 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000897.1 |  |  | 0.38 | Other | dehydrophos | Streptomyces luridus
BGC0000572.1 |  |  | 0.32 | RiPP | capistruin | Burkholderia thailandensis E444
BGC0001494.1 |  |  | 0.31 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0001222.1 |  |  | 0.31 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000560.1 |  |  | 0.30 | RiPP | subtilomycin | Bacillus subtilis
BGC0000517.1 |  |  | 0.30 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000543.1 |  |  | 0.30 | RiPP | pep5 | Staphylococcus epidermidis
BGC0001863.1 |  |  | 0.30 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000600.1 |  |  | 0.30 | RiPP | thurincin H | Bacillus thuringiensis
BGC0001618.1 |  |  | 0.29 | RiPP | hyicin 3682 | Staphylococcus hyicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000897.1 |  | 0.55 | Other | dehydrophos | Streptomyces luridus
BGC0000572.1 |  | 0.46 | RiPP | capistruin | Burkholderia thailandensis E444
BGC0001618.1 |  | 0.46 | RiPP | hyicin 3682 | Staphylococcus hyicus
BGC0001494.1 |  | 0.46 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0001222.1 |  | 0.45 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000560.1 |  | 0.45 | RiPP | subtilomycin | Bacillus subtilis
BGC0000517.1 |  | 0.45 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000543.1 |  | 0.45 | RiPP | pep5 | Staphylococcus epidermidis
BGC0001863.1 |  | 0.45 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000600.1 |  | 0.45 | RiPP | thurincin H | Bacillus thuringiensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP084662.1 - Region 5 - LAP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,650,602 - 3,674,361 nt. (total: 23,760 nt) Show pHMM detection rules used
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | LAP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001170.1 |  | 0.63 | RiPP | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.1 |  | 0.58 | RiPP | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001173.1 |  | 0.31 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.1 |  | 0.30 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0000566.1 |  | 0.28 | RiPP | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0000568.1 |  | 0.26 | RiPP | microcin B17 | Escherichia coli
BGC0001171.1 |  | 0.22 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000605.1 |  | 0.19 | RiPP | GE37468 | Streptomyces sp. ATCC 55365
BGC0000601.1 |  | 0.18 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0001579.1 |  | 0.18 | RiPP | duramycin | Streptomyces cinnamoneus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001170.1 |  | 0.85 | RiPP | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.1 |  | 0.83 | RiPP | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001173.1 |  | 0.64 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.1 |  | 0.64 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0000566.1 |  | 0.61 | RiPP | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0000568.1 |  | 0.59 | RiPP | microcin B17 | Escherichia coli
BGC0001171.1 |  | 0.55 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000605.1 |  | 0.51 | RiPP | GE37468 | Streptomyces sp. ATCC 55365
BGC0000601.1 |  | 0.50 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0001579.1 |  | 0.49 | RiPP | duramycin | Streptomyces cinnamoneus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP084662.1 - Region 6 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,839,416 - 3,866,959 nt. (total: 27,544 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001586.1 |  | 0.15 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0002007.1 |  | 0.14 | Terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0000807.1 |  | 0.14 | Saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0000527.1 |  | 0.13 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000343.1 |  | 0.13 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001686.1 |  | 0.12 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000043.1 |  | 0.11 | Polyketide | curacin A | Moorea producens 19L
BGC0002026.1 |  | 0.11 | NRP | thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2 | Jahnella sp. MSr9139
BGC0000310.1 |  | 0.11 | NRP | bacitracin | Bacillus licheniformis
BGC0000827.1 |  | 0.09 | Alkaloid | staurosporine | Salinispora arenicola CNS-205

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001586.1 |  | 0.46 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0002007.1 |  | 0.44 | Terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0000807.1 |  | 0.43 | Saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0000527.1 |  | 0.41 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000343.1 |  | 0.41 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001686.1 |  | 0.40 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000043.1 |  | 0.38 | Polyketide | curacin A | Moorea producens 19L
BGC0002026.1 |  | 0.38 | NRP | thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2 | Jahnella sp. MSr9139
BGC0000310.1 |  | 0.37 | NRP | bacitracin | Bacillus licheniformis
BGC0000827.1 |  | 0.34 | Alkaloid | staurosporine | Salinispora arenicola CNS-205

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP084662.1 - Region 7 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,069,715 - 4,081,919 nt. (total: 12,205 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.24 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  | 0.22 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.22 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.22 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.21 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000554.1 |  | 0.20 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000484.1 |  | 0.20 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000617.1 |  | 0.20 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.20 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000760.1 |  | 0.19 | Saccharide | emulsan | Acinetobacter venetianus RAG-1 = CIP 110063

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.57 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  | 0.55 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.55 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.54 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.54 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000554.1 |  | 0.53 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000484.1 |  | 0.53 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000617.1 |  | 0.52 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.52 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000760.1 |  | 0.51 | Saccharide | emulsan | Acinetobacter venetianus RAG-1 = CIP 110063

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP084663.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 26,999 - 45,443 nt. (total: 18,445 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.1 |  | 0.34 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0001364.1 |  | 0.25 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0000525.1 |  | 0.25 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000503.1 |  | 0.25 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000528.1 |  | 0.23 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000563.1 |  | 0.23 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001660.1 |  | 0.23 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0000532.1 |  | 0.22 | RiPP | mutacin II | Streptococcus mutans
BGC0000561.1 |  | 0.20 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000498.1 |  | 0.20 | RiPP | bovicin HJ50 | Streptococcus equinus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.1 |  | 0.67 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0001364.1 |  | 0.59 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0000525.1 |  | 0.58 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000503.1 |  | 0.58 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000528.1 |  | 0.57 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000563.1 |  | 0.56 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001660.1 |  | 0.56 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0000532.1 |  | 0.55 | RiPP | mutacin II | Streptococcus mutans
BGC0000561.1 |  | 0.52 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000498.1 |  | 0.52 | RiPP | bovicin HJ50 | Streptococcus equinus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg2_48 - Putative Class II

ctg2_50 leader / core peptide
  MTKNFDPAGIVDLKELDELAHIGGS - DVEAQDhb DhbPDhbIADhaVLVDhaVIDhaVELDhbVDhaAADhbVDhbAQCL
allorf_33711_33875 leader / core peptide
  MLLTLKELSLLIFLTVLHTA - LLCPDhaKDhaICLCNLLCIDhaVCLDhbPLLFIDFIDhbFDhaLF

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg2_50 - Class II
  Cleavage pHMM score: -2.30
  RODEO score: 0
  Monoisotopic mass: 3235.8 Da
  Molecular weight: 3237.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3255.7 Da N = 1
    3273.7 Da N = 2
    3291.7 Da N = 3
    3309.8 Da N = 4
    3327.8 Da N = 5
    3345.8 Da N = 6
    3363.8 Da N = 7
    3381.8 Da N = 8
    3399.9 Da N = 9
allorf_33711_33875 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 3684.0 Da
  Molecular weight: 3686.6 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3704.6 Da N = 1