LOCUS       NZ_CP013019.1          19593 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP013019.1 Clostridium pasteurianum strain M150B chromosome,
            complete genome.
ACCESSION   NZ_CP013019
VERSION     NZ_CP013019.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:30:35
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2732237
            Orig. end    :: 2751830
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..495
                     /locus_tag="ctg1_2489"
                     /transl_table=11
                     /translation="MKIFRDKRFSIIWTVLRIWLGYQWLTAGIEKITGQGWIGSKAGVS
                     ITGFLKGALAKATGEHPLVQWWYASFIKSFALPNAKIFSYLVAFGEILVGISLILGALT
                     IVGLIAGAFMNLNYMLAGTTSTNPILYTAAILLMVAGTNAYILGLDRFILPKIFNKKIT
                     S"
     protocluster    1..19593
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2742096:2742240](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(9860..10003)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..19593
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..19593
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="8"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     PFAM_domain     37..357
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2489_0165"
                     /evalue="1.30E-08"
                     /label="ctg1_2489"
                     /locus_tag="ctg1_2489"
                     /protein_end="119"
                     /protein_start="12"
                     /score="35.4"
                     /tool="antismash"
                     /translation="WTVLRIWLGYQWLTAGIEKITGQGWIGSKAGVSITGFLKGALAKA
                     TGEHPLVQWWYASFIKSFALPNAKIFSYLVAFGEILVGISLILGALTIVGLIAGAFMNL
                     NYM"
     CDS             536..1072
                     /locus_tag="ctg1_2490"
                     /transl_table=11
                     /translation="MKKKLIKNVVLGLLFVLALSTTALADSDGTKIEKNVDGIKADLIL
                     SSDTLKTGDNELTIKLYDTKGQPIENANVKVTADMPGNNMDDMKMNNSKPEAIDFKPGH
                     EKGEYTGTVNFSDKGNWTIKTDFTAANQEKMADFDVKVSSSGPNWFVIGGFLGLVALII
                     IIAAVSKSKKKASAA"
     PFAM_domain     635..907
                     /aSDomain="YtkA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13115.8"
                     /description="YtkA-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2490_0166"
                     /evalue="5.50E-13"
                     /label="ctg1_2490"
                     /locus_tag="ctg1_2490"
                     /protein_end="124"
                     /protein_start="33"
                     /score="49.4"
                     /tool="antismash"
                     /translation="KNVDGIKADLILSSDTLKTGDNELTIKLYDTKGQPIENANVKVTA
                     DMPGNNMDDMKMNNSKPEAIDFKPGHEKGEYTGTVNFSDKGNWTIK"
     CDS             1093..2484
                     /locus_tag="ctg1_2491"
                     /transl_table=11
                     /translation="MEEKEKTKYEDKKDSNSSSNVNLLKNKMFKKFMQSRWYPGIFQWP
                     VLIVFAFIVYELLVGPSVAHDNFGTAGTWVLWWPLLPIMLFLLGRFWCAICPFGLINDL
                     VQKFVGNNRPVPKFLRKYGIWIIDAMFIMITWSDHVWGVVESPRGSAVVLLIITAGVIF
                     SGAFFERRTWCRYLCFLGGVSSNYTRVGMMELRATPEKCAKCKVLACYKGSEKADGCPM
                     FEFPRAMETNAECNFCGNCVKNCPNDSIKMYPRVPTKELWSIRKPKLPESFLAVVIMGI
                     VFVQNITMLAIWKDILSWLERTTGTTSYYVTFTVTFIIAMLIPIILLSVTGLIAKKFNG
                     DSVRQNFARFGYAIIPLDLAAHIAHNLFHLLAEGKSVIFTFVELFGVNMHGSTALLDNE
                     TIQALQYILIVIGALGSIYTVYKISKHTYGNKNSIKTTVVYTILLVFLAVVNLILFALP
                     MEMRM"
     PFAM_domain     1303..1434
                     /aSDomain="Fer4_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12801.9"
                     /description="4Fe-4S binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2491_0167"
                     /evalue="3.60E-09"
                     /label="ctg1_2491"
                     /locus_tag="ctg1_2491"
                     /protein_end="114"
                     /protein_start="70"
                     /score="36.5"
                     /tool="antismash"
                     /translation="AGTWVLWWPLLPIMLFLLGRFWCAICPFGLINDLVQKFVGNNRP"
     CDS             2766..3392
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2492"
                     /sec_met_domain="Abi (E-value: 9.2e-19, bitscore: 65.6,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTENKKSLAYICFTLILASVLWYLLFVIKPFNFWIEMSISIFILI
                     LAASFSKNSIFVFKKIALKDILLGIFSAIVLYAIFYLGNIISGYLFSFKDTEILSIYNN
                     KAQGNLKLISLLLLLSIGPGEEIYWRGFIQTTLSRILGENKGYILSAVLYALVHIITGN
                     FMLVLAALVCGLYLGWIYKRKQTLTPVIISHALWDLIIFVLFPLI"
     PFAM_domain     3099..3362
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2492_0168"
                     /evalue="7.80E-18"
                     /label="ctg1_2492"
                     /locus_tag="ctg1_2492"
                     /protein_end="199"
                     /protein_start="111"
                     /score="64.7"
                     /tool="antismash"
                     /translation="LISLLLLLSIGPGEEIYWRGFIQTTLSRILGENKGYILSAVLYAL
                     VHIITGNFMLVLAALVCGLYLGWIYKRKQTLTPVIISHALWDL"
     CDS             3408..4124
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 84.3; E-value:
                     1.6e-25)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2493"
                     /sec_met_domain="PCMT (E-value: 1.4e-05, bitscore: 22.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSEKSNVQNIFSSIAEKYDILNTVLTLNIDSLWRKKAINISNIN
                     EDSKVLDLCCGTGKMVYYTCKKVGKNTEVIGLDFNEAMLEVGYKNLNKSIPDYKFKLLK
                     GDVQALPFKDCSFDCVTIAFGLRNIPNKTKALSEIYRVLKPGGKAICLELSTPQIPIFK
                     QVYGVYFNNILPIIGYLGTGDKNAYSYLRDSVNKFMSKSDLKYAFESTGFKNASYKSLS
                     GGIASIHYGTKPIVIK"
     PFAM_domain     3414..4106
                     /aSDomain="Ubie_methyltran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01209.20"
                     /description="ubiE/COQ5 methyltransferase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2493_0169"
                     /evalue="1.50E-72"
                     /label="ctg1_2493"
                     /locus_tag="ctg1_2493"
                     /protein_end="233"
                     /protein_start="2"
                     /score="243.8"
                     /tool="antismash"
                     /translation="SEKSNVQNIFSSIAEKYDILNTVLTLNIDSLWRKKAINISNINED
                     SKVLDLCCGTGKMVYYTCKKVGKNTEVIGLDFNEAMLEVGYKNLNKSIPDYKFKLLKGD
                     VQALPFKDCSFDCVTIAFGLRNIPNKTKALSEIYRVLKPGGKAICLELSTPQIPIFKQV
                     YGVYFNNILPIIGYLGTGDKNAYSYLRDSVNKFMSKSDLKYAFESTGFKNASYKSLSGG
                     IASIHYGTK"
     aSDomain        3429..4106
                     /aSDomain="TIGR01934"
                     /aSTool="tigrfam"
                     /description="MenG_MenH_UbiE: ubiquinone/menaquinone
                     biosynthesis methyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2493_0044"
                     /evalue="4.00E-76"
                     /identifier="TIGR01934"
                     /label="ctg1_2493"
                     /locus_tag="ctg1_2493"
                     /protein_end="233"
                     /protein_start="7"
                     /score="253.2"
                     /tool="antismash"
                     /translation="VQNIFSSIAEKYDILNTVLTLNIDSLWRKKAINISNINEDSKVLD
                     LCCGTGKMVYYTCKKVGKNTEVIGLDFNEAMLEVGYKNLNKSIPDYKFKLLKGDVQALP
                     FKDCSFDCVTIAFGLRNIPNKTKALSEIYRVLKPGGKAICLELSTPQIPIFKQVYGVYF
                     NNILPIIGYLGTGDKNAYSYLRDSVNKFMSKSDLKYAFESTGFKNASYKSLSGGIASIH
                     YGTK"
     CDS             complement(4577..5989)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 201.8; E-value: 4.4e-61)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2494"
                     /transl_table=11
                     /translation="VKITLGKKLALGFFIALMGSLIITGIISNLRISNEFSKYLVDEHN
                     TRINEIVKFIEDSYNKDNGFSGDSQEAMVRNANMNELYIEVRDNSGSILFSSGTTYMQH
                     KNMMNSMMGEGKNGMMGNLSSINSGEYKEEKHELTKDNSVVGTIIIGYYGSSYFSSNSL
                     AFINNLNQSFIISFFITLIFGLLITFFLSRQIASPLEKITKTASEMRMGNLKVRSNIKS
                     NTKEIEELACSINYLAETLQNQEELRKRLTSDMAHEIRTPLTTLKTHVEALIDGIWEPS
                     KERFQVFYEELDRLSKLVNNLRNISKFEQADITLNKSKFNLSSEIANIVDTFKPIFMRK
                     NCMITAEVAENIIVYMDKDNLKQILHNLLSNANNYLEINGRVKVSLFEKKDHIIIEVED
                     NGIGISEKDLPYIFERFYRSDISRDKNTGGSGLGLTITKSLVEANGGKIRVKGKIGEGT
                     VFSISFPKNICL"
     PFAM_domain     complement(4592..4921)
                     /aSDomain="HATPase_c"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02518.28"
                     /description="Histidine kinase-, DNA gyrase B-, and
                     HSP90-like ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2494_0172"
                     /evalue="2.60E-24"
                     /label="ctg1_2494"
                     /locus_tag="ctg1_2494"
                     /protein_end="466"
                     /protein_start="356"
                     /score="86.0"
                     /tool="antismash"
                     /translation="DKDNLKQILHNLLSNANNYLEINGRVKVSLFEKKDHIIIEVEDNG
                     IGISEKDLPYIFERFYRSDISRDKNTGGSGLGLTITKSLVEANGGKIRVKGKIGEGTVF
                     SISFPK"
     PFAM_domain     complement(5060..5248)
                     /aSDomain="HisKA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00512.27"
                     /description="His Kinase A (phospho-acceptor) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2494_0171"
                     /evalue="2.50E-12"
                     /label="ctg1_2494"
                     /locus_tag="ctg1_2494"
                     /protein_end="310"
                     /protein_start="247"
                     /score="46.7"
                     /tool="antismash"
                     /translation="RKRLTSDMAHEIRTPLTTLKTHVEALIDGIWEPSKERFQVFYEEL
                     DRLSKLVNNLRNISKFEQ"
     PFAM_domain     complement(5264..5422)
                     /aSDomain="HAMP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00672.27"
                     /description="HAMP domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2494_0170"
                     /evalue="5.80E-08"
                     /label="ctg1_2494"
                     /locus_tag="ctg1_2494"
                     /protein_end="242"
                     /protein_start="189"
                     /score="33.1"
                     /tool="antismash"
                     /translation="FLSRQIASPLEKITKTASEMRMGNLKVRSNIKSNTKEIEELACSI
                     NYLAETLQ"
     CDS             complement(6022..6726)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 217.9; E-value: 2.1e-66)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2495"
                     /transl_table=11
                     /translation="MKDTINILVVDDEYTILEVIKAYLEKDNFKVYIATNGEEAIEIFK
                     KENIKLIVLDLMLPKISGEEVCRKVRSVSDVPIIMLTAKIEEDDKIEGLAIGADDYLTK
                     PFSVRELVGRIRALLRRAYRDDNPLADYLVFNDGDLKIDVRKMKVKKKNKEIDITPYEF
                     KVLVALLTNPGQVFTREQLVKKAFGIEYEGFDRTVDSYIKNVRHKIEDDTKNPKYISTV
                     YGVGYKFTGSKS"
     PFAM_domain     complement(6040..6267)
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2495_0174"
                     /evalue="8.40E-25"
                     /label="ctg1_2495"
                     /locus_tag="ctg1_2495"
                     /protein_end="229"
                     /protein_start="153"
                     /score="86.8"
                     /tool="antismash"
                     /translation="KEIDITPYEFKVLVALLTNPGQVFTREQLVKKAFGIEYEGFDRTV
                     DSYIKNVRHKIEDDTKNPKYISTVYGVGYKF"
     PFAM_domain     complement(6382..6708)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2495_0173"
                     /evalue="3.40E-29"
                     /label="ctg1_2495"
                     /locus_tag="ctg1_2495"
                     /protein_end="115"
                     /protein_start="6"
                     /score="101.4"
                     /tool="antismash"
                     /translation="ILVVDDEYTILEVIKAYLEKDNFKVYIATNGEEAIEIFKKENIKL
                     IVLDLMLPKISGEEVCRKVRSVSDVPIIMLTAKIEEDDKIEGLAIGADDYLTKPFSVRE
                     LVGRI"
     CDS             complement(6800..7036)
                     /locus_tag="ctg1_2496"
                     /transl_table=11
                     /translation="MFGCGYGNGFIGVGGPYLIIFMIIRLLIIIGIVVAAVKLFKGYFK
                     VNNNAIKTLDNMYAKGEISEEEYKKRKEFIKNN"
     PFAM_domain     complement(6818..6889)
                     /aSDomain="SHOCT"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09851.11"
                     /description="Short C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2496_0175"
                     /evalue="5.40E-08"
                     /label="ctg1_2496"
                     /locus_tag="ctg1_2496"
                     /protein_end="73"
                     /protein_start="49"
                     /score="32.4"
                     /tool="antismash"
                     /translation="AIKTLDNMYAKGEISEEEYKKRKE"
     CDS             7321..8184
                     /locus_tag="ctg1_2497"
                     /transl_table=11
                     /translation="MTNNNIKIKKSIPFDAKRKIVAHATGESWYNIPHITYNYEPDITN
                     FYEEFVELSKKLKSEGKKISFNSLMIKVISEGLLSAADLNSYLEYDHEKCDGTLHILDE
                     INIAIPWILSDGSHITPSIMNAGKLSLEEISDYISNLTNKINNSDIKEITNILSSEFSS
                     EKPYLEGKEKDNYYKIPDSERLTKEDFIYGTITFSNIGSLYREQKGSFCLLEVIPPQVF
                     AIGLSSVQEKPGVFLDDNGSKQIGIRKTLPMCLAFDHRALDFSSIIPFLKKLDSIFDDP
                     SVIHQW"
     PFAM_domain     7348..7773
                     /aSDomain="2-oxoacid_dh"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00198.25"
                     /description="2-oxoacid dehydrogenases acyltransferase
                     (catalytic domain)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2497_0176"
                     /evalue="8.30E-16"
                     /label="ctg1_2497"
                     /locus_tag="ctg1_2497"
                     /protein_end="151"
                     /protein_start="9"
                     /score="58.2"
                     /tool="antismash"
                     /translation="KSIPFDAKRKIVAHATGESWYNIPHITYNYEPDITNFYEEFVELS
                     KKLKSEGKKISFNSLMIKVISEGLLSAADLNSYLEYDHEKCDGTLHILDEINIAIPWIL
                     SDGSHITPSIMNAGKLSLEEISDYISNLTNKINNSDIK"
     PFAM_domain     7864..8169
                     /aSDomain="2-oxoacid_dh"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00198.25"
                     /description="2-oxoacid dehydrogenases acyltransferase
                     (catalytic domain)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2497_0177"
                     /evalue="6.10E-10"
                     /label="ctg1_2497"
                     /locus_tag="ctg1_2497"
                     /protein_end="283"
                     /protein_start="181"
                     /score="39.1"
                     /tool="antismash"
                     /translation="SERLTKEDFIYGTITFSNIGSLYREQKGSFCLLEVIPPQVFAIGL
                     SSVQEKPGVFLDDNGSKQIGIRKTLPMCLAFDHRALDFSSIIPFLKKLDSIFDDPSV"
     CDS             complement(8454..9779)
                     /locus_tag="ctg1_2498"
                     /transl_table=11
                     /translation="MAIIMEILSDVIESLLFLGIFAALHNKKRFLIENKLRSILFCILF
                     VSMTYFSTIYINNIYRILFITIFDILLLAYITRIKIFASIVIFFVFLSVLSVTEYFIGI
                     IEMIILNINLNQIFLNFKYSLVFIIATKIMQVIIVLLLFRFSKYFNKFKLFQQEGILFS
                     NLIMQIGVFALLILIINFSIFDVKDLKIYNCFIFIVYFIFLIIQLNGLKEYRRIVNVEA
                     KYKIQEHQIKDMEEIIKIIRQEKHDFANHINVIWGLCSLNKPDTVEKIKNYVNGISNTL
                     HSSFKYIDTGNDCLSGLLSIKSNYAVKNNINFDIMIDEPFSSIEIKENDLISIISNIID
                     NAFEAFEVKSNIENKEITIDSFSKDNKFFIEISNNGDMIPEDIQNKIFDRGFSTKTKKS
                     QDHGFGLYIIKQLIEQNNGIISLESTLERTTFLIEFKMKEFR"
     PFAM_domain     complement(8505..8804)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2498_0179"
                     /evalue="4.70E-15"
                     /label="ctg1_2498"
                     /locus_tag="ctg1_2498"
                     /protein_end="425"
                     /protein_start="325"
                     /score="55.4"
                     /tool="antismash"
                     /translation="IKENDLISIISNIIDNAFEAFEVKSNIENKEITIDSFSKDNKFFI
                     EISNNGDMIPEDIQNKIFDRGFSTKTKKSQDHGFGLYIIKQLIEQNNGIISLEST"
     PFAM_domain     complement(8970..9098)
                     /aSDomain="SPOB_a"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14689.8"
                     /description="Sensor_kinase_SpoOB-type, alpha-helical
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2498_0178"
                     /evalue="2.00E-10"
                     /label="ctg1_2498"
                     /locus_tag="ctg1_2498"
                     /protein_end="270"
                     /protein_start="227"
                     /score="40.2"
                     /tool="antismash"
                     /translation="EHQIKDMEEIIKIIRQEKHDFANHINVIWGLCSLNKPDTVEKI"
     CDS             complement(9860..10003)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2499"
                     /sec_met_domain="TIGR04223 (E-value: 2.2e-08, bitscore:
                     31.9, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNIKNLLVSKSMKFLGSIALFLGAIVIVPTSTLLGHQPKCPDEF
                     LK"
     aSDomain        complement(9863..9973)
                     /aSDomain="TIGR04223"
                     /aSTool="tigrfam"
                     /description="quorum_AgrD: cyclic lactone autoinducer
                     peptide"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2499_0045"
                     /evalue="2.40E-08"
                     /identifier="TIGR04223"
                     /label="ctg1_2499"
                     /locus_tag="ctg1_2499"
                     /protein_end="47"
                     /protein_start="10"
                     /score="31.9"
                     /tool="antismash"
                     /translation="KSMKFLGSIALFLGAIVIVPTSTLLGHQPKCPDEFLK"
     CDS             10603..10971
                     /locus_tag="ctg1_2500"
                     /transl_table=11
                     /translation="MDLKVKEKKLKLDIPTVFIALKKKETPVIAKIFAVITIGYALSPI
                     DFIPDFIPVIGLLDDLILLPILVVITIKFIPEEIFNKCRIEAENLWIIGKPKRWYFAIP
                     IVSIWLAFILLIIKLVIT"
     PFAM_domain     10690..10797
                     /aSDomain="DUF1232"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06803.14"
                     /description="Protein of unknown function (DUF1232)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2500_0180"
                     /evalue="2.70E-12"
                     /label="ctg1_2500"
                     /locus_tag="ctg1_2500"
                     /protein_end="65"
                     /protein_start="29"
                     /score="46.3"
                     /tool="antismash"
                     /translation="AKIFAVITIGYALSPIDFIPDFIPVIGLLDDLILLP"
     CDS             complement(12478..12672)
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 57.4; E-value: 4e-17)"
                     /gene_kind="other"
                     /locus_tag="ctg1_2501"
                     /transl_table=11
                     /translation="MKNNIKKLRKELGYRQEDMANTLGVTRQTINAIENEKYNPTLELG
                     MKLARLLNTTVEELFILDS"
     PFAM_domain     complement(12496..12660)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2501_0181"
                     /evalue="6.10E-17"
                     /label="ctg1_2501"
                     /locus_tag="ctg1_2501"
                     /protein_end="59"
                     /protein_start="4"
                     /score="61.5"
                     /tool="antismash"
                     /translation="IKKLRKELGYRQEDMANTLGVTRQTINAIENEKYNPTLELGMKLA
                     RLLNTTVEEL"
     CDS             complement(12662..12877)
                     /locus_tag="ctg1_2502"
                     /transl_table=11
                     /translation="MRKMDEMELSINLKAIKWAWAYTIIFLFGWIVYDYLHGNRNSVSL
                     FLLITQNFVWIAVQYFLKWKMNKDEK"
     CDS             complement(13219..13545)
                     /locus_tag="ctg1_2503"
                     /transl_table=11
                     /translation="MDNDVKVYKENLMKNIFYTEEEVSKEEYKKLDKDERYTLGSDLGE
                     GEKYYKKIPLNIDDSELALLIQLKIYERLEQIDNKQSTIKNIMVFWLIITIIGLSIGVI
                     LINN"
     CDS             complement(13948..14343)
                     /locus_tag="ctg1_2504"
                     /transl_table=11
                     /translation="MKDRNKGIAQSISMFGIFFGRWFSRNFGDNTYFGLNGRVLIGIIA
                     GIIIGMALIILITKKFYFASFIFLVLFSPMIITYIGMYYDNTTLMDVGFVTFIIILIIF
                     LIITKRYVRTTNDSDDNINYDRYKNKY"
     CDS             complement(14515..14895)
                     /locus_tag="ctg1_2505"
                     /transl_table=11
                     /translation="MKYISIEYVLKLHSKLIETTGGSSELRDIELLKSSIENSKATFNG
                     QNLYPTIEDKCANICYSMINNHPFVDGNKRIGLYVMLILLEYNGIKLKFTQNELINLGL
                     GIAKGDFKQEYIILWTKNHYAK"
     aSDomain        complement(14545..14889)
                     /aSDomain="TIGR01550"
                     /aSTool="tigrfam"
                     /description="DOC_P1: death-on-curing family protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2505_0046"
                     /evalue="1.30E-19"
                     /identifier="TIGR01550"
                     /label="ctg1_2505"
                     /locus_tag="ctg1_2505"
                     /protein_end="117"
                     /protein_start="2"
                     /score="68.5"
                     /tool="antismash"
                     /translation="YISIEYVLKLHSKLIETTGGSSELRDIELLKSSIENSKATFNGQN
                     LYPTIEDKCANICYSMINNHPFVDGNKRIGLYVMLILLEYNGIKLKFTQNELINLGLGI
                     AKGDFKQEYII"
     PFAM_domain     complement(14641..14889)
                     /aSDomain="Fic"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02661.20"
                     /description="Fic/DOC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2505_0182"
                     /evalue="9.20E-13"
                     /label="ctg1_2505"
                     /locus_tag="ctg1_2505"
                     /protein_end="85"
                     /protein_start="2"
                     /score="49.0"
                     /tool="antismash"
                     /translation="YISIEYVLKLHSKLIETTGGSSELRDIELLKSSIENSKATFNGQN
                     LYPTIEDKCANICYSMINNHPFVDGNKRIGLYVMLILL"
     CDS             complement(14892..15131)
                     /locus_tag="ctg1_2506"
                     /transl_table=11
                     /translation="MLVNTKKIISMSEANQNFSKVAKMVDEDKSVVIMKNNKPKYILLD
                     FEEFSKETSSEEQLDTIADRILEENMEAFKELAK"
     PFAM_domain     complement(14922..15113)
                     /aSDomain="PhdYeFM_antitox"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02604.21"
                     /description="Antitoxin Phd_YefM, type II toxin-antitoxin
                     system"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2506_0183"
                     /evalue="2.80E-11"
                     /label="ctg1_2506"
                     /locus_tag="ctg1_2506"
                     /protein_end="70"
                     /protein_start="6"
                     /score="43.2"
                     /tool="antismash"
                     /translation="KIISMSEANQNFSKVAKMVDEDKSVVIMKNNKPKYILLDFEEFSK
                     ETSSEEQLDTIADRILEEN"
     aSDomain        complement(14976..15107)
                     /aSDomain="TIGR01552"
                     /aSTool="tigrfam"
                     /description="phd_fam: prevent-host-death family protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2506_0047"
                     /evalue="4.60E-06"
                     /identifier="TIGR01552"
                     /label="ctg1_2506"
                     /locus_tag="ctg1_2506"
                     /protein_end="52"
                     /protein_start="8"
                     /score="23.9"
                     /tool="antismash"
                     /translation="ISMSEANQNFSKVAKMVDEDKSVVIMKNNKPKYILLDFEEFSKE"
     CDS             complement(15277..17331)
                     /locus_tag="ctg1_2507"
                     /transl_table=11
                     /translation="MLQKKKDLQDENNSAIDYENKIKKDQLELDNAQNEKTVLITENGQ
                     AMWVADQTRIDSAREQLAKDQEDYRRWKENQAIEKQKTDIQDKIDATSKAKDIAQENYN
                     TQKDAIEKTYETKFEAIDAQKDAISNQKDDISNQKNQLNDKKSDLAEQQNNINNSRNAL
                     DGYAKGTDDADEGIAEVAENGLEIVIGRQSRKFQGGEQVIPHNESMNILNGTNSIDVNS
                     DSSKNIDKQSKSAKNTLNAIGTTIENNKNLVKKPVNELLDEVDDNVQHFVNESPQYGKD
                     TNKNVGDSVTNNKLLVKKPVDDLITEVVNLIQNFVNNAGQYGQNTDKNIGTGITNTQES
                     VLTPTRTLISNVKGLITPFVSSMQGAGKNIDINIGKGLSDGNDDLMKNIENLCKKMVDK
                     FNEKLDIHSPSKVMYKIGQYMIEGLIKGMDESDIEKFITDKVSGMTGAINGQVANVPGS
                     VTDWLKEAIKLTGVPESWLPALQTIAMHESSGNPNDINNWDSNAKAGHPSQGLMQTIPS
                     TFAENMVSGHNQILNPIDNAAAAINYIKSRYGTVSNVPGIKALARGGNYIGYASGEEYV
                     PETDRYQINEKGEETILLNKGSGVVTSERTRGLNILADNVPNIMNTVDKLSMFMPQLNT
                     PDFSNIKLPQQSQNIDNSKKIHIDNVEIVQPTDFEDFVTQFEQYVITHT"
     PFAM_domain     complement(15571..15915)
                     /aSDomain="SLT"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01464.22"
                     /description="Transglycosylase SLT domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2507_0184"
                     /evalue="1.20E-14"
                     /label="ctg1_2507"
                     /locus_tag="ctg1_2507"
                     /protein_end="587"
                     /protein_start="472"
                     /score="54.1"
                     /tool="antismash"
                     /translation="PESWLPALQTIAMHESSGNPNDINNWDSNAKAGHPSQGLMQTIPS
                     TFAENMVSGHNQILNPIDNAAAAINYIKSRYGTVSNVPGIKALARGGNYIGYASGEEYV
                     PETDRYQINEK"
     CDS             17560..18132
                     /locus_tag="ctg1_2508"
                     /transl_table=11
                     /translation="MINIVKMPYGIKKYNKLCKFNQFPSKYGCEACGFEGKLYRHGFYY
                     RNLITLKGAYKIVILRCKCQSCGKTYSLIPSFIIPYRQYAYEVILTSIIMMLKLGYSFS
                     KILTLIKSLNINYSSLNTTDLSFWKNRLVSSLSSIRLFFAQYKFYNSNINSKLPIDIIK
                     KIIIFCRLRHDFNLDYFLHMPKYFFCK"
     PFAM_domain     17644..17838
                     /aSDomain="DUF6431"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF20020.1"
                     /description="Domain of unknown function (DUF6431)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2508_0185"
                     /evalue="2.60E-11"
                     /label="ctg1_2508"
                     /locus_tag="ctg1_2508"
                     /protein_end="93"
                     /protein_start="28"
                     /score="43.3"
                     /tool="antismash"
                     /translation="CEACGFEGKLYRHGFYYRNLITLKGAYKIVILRCKCQSCGKTYSL
                     IPSFIIPYRQYAYEVILTSI"
     CDS             18331..19593
                     /locus_tag="ctg1_2509"
                     /transl_table=11
                     /translation="MILKEFNQKIALFRYSLIAPIITNTFTQTSVKDYLAEIAAKSYTL
                     PNGKKKEYSPATIKGWLVQYRKYGIDGLYPKSRADKGTSRKISNETKEFIINSKLNSPK
                     KTAKYIYHEVIAKGFESETSISLSTVTRFINKAKIGSKKLVPDDRRAFEFEFSNECWQS
                     DVSVGPYLTIEDKKFKTYIIAFLDDSSRVIVGCKAFFKDDLLSLMSVFKDAVASKGIPK
                     KVFVDNGKIYKSEQFHLICAALGSILSFARPYSPQSKGKIERWFQTMQKQWMNSINWND
                     FKSIDLLNESLSGYVNSYNNTIHSSINKKPIDKYMSNVENIRFIDSKTELDYLFLYKVL
                     RTVKNDSTVSIGTKIFEVPLKYVGDKINIRYDPSSIDKAYIFSQDGKLEDTIFPVKKID
                     NSKIRRTNNTNSVDFSAFEAN"
     PFAM_domain     18799..19098
                     /aSDomain="rve"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00665.28"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2509_0186"
                     /evalue="3.10E-14"
                     /label="ctg1_2509"
                     /locus_tag="ctg1_2509"
                     /protein_end="256"
                     /protein_start="156"
                     /score="53.2"
                     /tool="antismash"
                     /translation="SNECWQSDVSVGPYLTIEDKKFKTYIIAFLDDSSRVIVGCKAFFK
                     DDLLSLMSVFKDAVASKGIPKKVFVDNGKIYKSEQFHLICAALGSILSFARPYSP"
     PFAM_domain     19072..19260
                     /aSDomain="rve_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13683.8"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2509_0187"
                     /evalue="3.50E-07"
                     /label="ctg1_2509"
                     /locus_tag="ctg1_2509"
                     /protein_end="310"
                     /protein_start="247"
                     /score="30.0"
                     /tool="antismash"
                     /translation="LSFARPYSPQSKGKIERWFQTMQKQWMNSINWNDFKSIDLLNESL
                     SGYVNSYNNTIHSSINKK"
     PFAM_domain     19327..19491
                     /aSDomain="Mu-transpos_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09299.13"
                     /description="Mu transposase, C-terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2509_0188"
                     /evalue="1.60E-06"
                     /label="ctg1_2509"
                     /locus_tag="ctg1_2509"
                     /protein_end="387"
                     /protein_start="332"
                     /score="28.0"
                     /tool="antismash"
                     /translation="YLFLYKVLRTVKNDSTVSIGTKIFEVPLKYVGDKINIRYDPSSID
                     KAYIFSQDGK"
ORIGIN
        1 atgaaaatat ttcgtgacaa aagatttagt ataatttgga cagttctgcg tatttggctt
       61 ggatatcagt ggctaactgc aggaatagaa aaaattaccg ggcaaggttg gattggaagt
      121 aaagctggtg tatccataac aggctttcta aagggtgcgc ttgcaaaagc cacaggagag
      181 catccattag tacaatggtg gtatgcaagt tttattaaaa gcttcgccct gcctaatgct
      241 aaaattttta gttatttagt tgcatttgga gaaatattag ttggtatttc tttaattctt
      301 ggagctttaa ctattgttgg tcttattgca ggagctttca tgaatttaaa ctatatgtta
      361 gcaggtacaa ctagtacaaa tcctatttta tatactgcag ctattttact tatggttgct
      421 ggtaccaatg catatatttt aggacttgat agatttattt tacctaagat atttaataaa
      481 aaaatcacca gttaatgttt taatgaaatt tatttaatag gaggaatttt acgatatgaa
      541 aaaaaaatta atcaaaaatg tagtgttagg tttacttttc gtacttgcat tatccacaac
      601 agcactggcg gatagcgacg gaactaaaat cgagaaaaat gtagatggaa taaaagcaga
      661 cttaatttta agcagtgata cattgaaaac tggcgataat gaattaacaa ttaaacttta
      721 tgatacaaag ggacaaccaa tagaaaatgc aaatgttaaa gtaactgctg atatgccagg
      781 taataatatg gatgacatga agatgaataa ttctaagcct gaagctattg actttaaacc
      841 aggtcatgaa aagggagaat atactggaac cgtaaatttc tctgataaag gtaattggac
      901 aattaaaaca gattttacag cagcaaatca ggaaaaaatg gctgattttg atgtaaaagt
      961 gtctagttct ggtcccaatt ggtttgtaat aggtggtttc ctaggtttag ttgctttaat
     1021 cattattatc gctgcagtat ctaaaagtaa gaagaaagct tcagcagcct agaaagcgag
     1081 gtaataattc ttatggaaga aaaagaaaaa acaaaatatg aggataaaaa agattctaat
     1141 tcctcgtcca atgtaaattt acttaaaaat aaaatgttta aaaaatttat gcaaagcaga
     1201 tggtatcctg gtatatttca gtggccagtt ttaatagttt ttgcttttat tgtctatgaa
     1261 ttattagttg gcccatctgt tgctcacgac aactttggta cagctggtac atgggtgctc
     1321 tggtggcctt tacttccaat catgttattt ctccttggaa gattttggtg tgctatatgt
     1381 ccctttggac ttataaatga tcttgtacaa aagtttgttg gcaataatcg tccagttcct
     1441 aaattcttga gaaaatatgg aatatggatt atagatgcaa tgtttataat gataacctgg
     1501 agcgaccatg tttggggagt tgttgaatcc cctcgtggtt cagcagttgt actactgatt
     1561 attaccgctg gagttatttt ttcaggtgcg ttctttgaac gcagaacctg gtgtagatat
     1621 ctatgcttcc ttggcggtgt atctagcaac tatacaagag ttggtatgat ggaactaaga
     1681 gcaactcctg aaaaatgtgc taaatgtaag gtacttgcct gctataaagg tagtgaaaaa
     1741 gctgatggat gtccaatgtt tgagttccca agagctatgg aaaccaatgc agaatgtaat
     1801 ttttgtggta attgtgtaaa aaattgtcct aatgattcca ttaaaatgta tccacgcgta
     1861 cctactaaag aattatggtc tattcgtaag ccaaagcttc cggaatcatt ccttgctgtt
     1921 gtaattatgg gtattgtatt tgttcaaaat atcactatgc tggctatatg gaaagatata
     1981 ttaagctggc ttgaacgcac aactggaact acaagctact atgtaacttt cactgtaact
     2041 tttattattg caatgctaat tcctattatt ctactttctg taacaggatt gattgcaaag
     2101 aaatttaatg gagactcagt tagacaaaat tttgccagat ttggatatgc tattatacca
     2161 ttagatttag cagctcatat agctcataac ttatttcatt tactagcaga aggtaaatct
     2221 gtaattttca cctttgtaga acttttcggg gtaaacatgc atggatcaac agctctatta
     2281 gataatgaaa ctatacaagc ccttcaatat atattaattg ttattggagc tttaggttca
     2341 atatatactg tatataagat ttcaaagcat acttatggaa acaaaaattc cataaaaacc
     2401 acagttgttt atacaatatt attagtattt ttagcagttg taaatcttat attatttgct
     2461 cttccaatgg aaatgcgtat gtaatttaag ctgttaaaat ctaaatatta aaactttaag
     2521 accatatctc tcatcaaaat ctaaggactc atacattgtg ttttaaaata tagcccctag
     2581 ttattagata agaatgatag tatggtctct ctttataaaa tattcatttc ctttaagtag
     2641 ctattatcta aatgtattta ttaaataaac aattttaatt gcaactttat acaatttcac
     2701 ataacaaata taattttgct taaattagct aatatgaatt tttacccttc aaaggagttg
     2761 tttttttgac tgaaaataaa aaaagtttag cttatatatg tttcacatta atattagcat
     2821 cagttttatg gtatttattg tttgttatta agccttttaa cttttggata gaaatgagta
     2881 tttctatatt tattctaata cttgctgcct cattttcaaa aaatagcatt tttgttttta
     2941 agaaaatagc cctcaaagat atacttttag gtattttttc agctattgtg ttatatgcta
     3001 tattttatct tggaaatata atatccggat atttattttc attcaaagat acagaaatac
     3061 tatcaattta caataataaa gcacagggaa acctaaaact tataagctta ctgcttcttt
     3121 tgtcaattgg tccaggagaa gaaatttact ggaggggctt tattcaaact actttatcta
     3181 gaatattggg agaaaataaa ggatatatct tatcagcagt actttatgca ttagtacaca
     3241 ttattactgg aaacttcatg ttagttttag cagctttagt gtgtggatta tatttgggat
     3301 ggatttacaa aagaaaacaa actcttacac cagtaattat atctcatgca ctttgggatc
     3361 ttataatatt tgttttattc ccattaatat aaaaaggagg ttagcatatg accagtgaaa
     3421 aatcaaatgt tcaaaatatc ttttcatcta ttgctgaaaa atatgatata ttgaatacag
     3481 tattaactct taatattgat agtctttgga gaaaaaaagc tataaatatt tcaaatataa
     3541 atgaagacag taaagttttg gatttatgct gcggtactgg taaaatggta tactatacct
     3601 gcaaaaaagt tggtaagaat actgaagtta taggtttaga tttcaatgaa gctatgcttg
     3661 aggtaggtta taaaaatctt aataaaagta ttcctgacta taaatttaaa ttacttaaag
     3721 gtgatgttca agcgctccct tttaaagact gcagctttga ttgtgtgact attgcctttg
     3781 gattaagaaa cattcccaat aagacaaagg cactatctga aatctacaga gttctaaaac
     3841 caggtggaaa agcaatttgc ttagaattat caactccaca aatacctata ttcaaacaag
     3901 tatatggagt atatttcaac aacatactcc ccattattgg atatttaggc actggtgata
     3961 aaaatgccta ttcctatctt agagactctg taaacaaatt tatgtcaaaa tctgatctga
     4021 agtatgcctt tgaatctaca ggtttcaaaa atgctagcta caaatccctg tccggaggta
     4081 tagcttctat acactatggt acaaagccca ttgtaattaa ataatatgtt attcttcatt
     4141 ttatctacat aattctatac tgtatacaaa tataagtata gatactacta gagatcctgt
     4201 atgcggtatg aatgtatcaa agaaagatgc tatctctaga aagatagatg acaagacata
     4261 ttatttttac agtaagaatt gcgctaatga atttgaaaga aatcatgtgc aatataaata
     4321 aaatgcttat atagtaataa atagcacctg aattaactga gttcttacta ggcaattcag
     4381 gtgttatttt tgaaaattat ataaaacaac tttatatata ttacaataaa ttatattcat
     4441 tacatataaa cagattctaa ctaaatctta tttattaaat gagcaattct aattgcaact
     4501 tatatataat tttgataata ggaatatatt gaattaaggt tcaagtattc tagattaaaa
     4561 ttagggatga ttagtattat aaacatatat ttttaggaaa gcttatacta aacacagtac
     4621 cttctccaat tttaccttta acccgtattt ttcctccatt agcttctact aaacttttag
     4681 ttatggtaag tccaaggcct gatccgccag tatttttgtc tcttgatata tcacttctat
     4741 aaaatctctc aaatatatag ggtaagtctt tttcagaaat gcctatacca ttgtcttcta
     4801 cctctattat aatatggtct tttttttcaa atagagatac ctttactctg ccattaattt
     4861 caagatagtt attggcattt gaaagaagat tgtgcagtat ttgttttaaa ttatctttat
     4921 ccatatatac aattatattt tctgcaactt cagccgtaat catgcagttt tttctcataa
     4981 atataggctt aaaagtatct acaatatttg caatttcaga agataaatta aatttacttt
     5041 tattcagagt tatatctgcc tgctcaaatt ttgatatgtt tctaagatta tttactaatt
     5101 ttgaaagtct atctaattct tcataaaata cttgaaatct ttcttttgag ggttcccata
     5161 tgccatcaat taaagcttca acatgagttt ttagagtagt aagcggagtc cttatttcat
     5221 gagccatatc agaagtaagc ctttttctga gttcttcttg attctgtaat gtttctgcaa
     5281 ggtagtttat tgagcaagct agttcttcta tttcttttgt attggatttt atattagaac
     5341 gaacttttaa attccccatt ctcatttcag aagcagtttt agttatcttt tcaagaggag
     5401 atgcaatctg ccttgataaa aagaaagtta ttaataatcc aaaaatcaat gttataaaaa
     5461 aagatattat aaaggattga ttaagattat ttataaacgc taatgaattg gaagaaaaat
     5521 aagagctgcc gtaataacca atgattattg tccccactac actattatct ttagtcagtt
     5581 catgtttttc ttctttgtac tctcctgaat taatactgga taaattgccc atcatgccgt
     5641 ttttcccttc gcccatcatt gaattcatca tatttttatg ctgcatgtac gtagtccctg
     5701 aagaaaacag aatactacct gaattatctc ttacttcaat atataattca ttcatatttg
     5761 catttctgac cattgcttcc tggctgtcac ctgaaaatcc attatcttta ttataagaat
     5821 cttcaataaa tttaactatt tcatttatcc ttgtattgtg ttcatctact aaatatttac
     5881 taaattcatt ggaaatcctt aaatttgaaa taataccagt aatgattaaa gagcccataa
     5941 gagcaataaa aaaacctaag gctaactttt taccaagtgt tattttcact actataacct
     6001 cctgtattaa ctaaaatatt attaagattt tgagcctgta aatttataac ctactccata
     6061 aactgtactt atatatttag gattcttagt gtcgtcttca attttatgtc ttacattctt
     6121 tatatagctg tccaccgttc tatcaaagcc ttcatattca attccaaagg cctttttaac
     6181 taattgttct cttgtaaata cctgaccagg attcgtaagt agtgctacca atactttaaa
     6241 ttcataagga gtgatatcta tttctttatt tttcttttta actttcattt ttctcacatc
     6301 tattttcaaa tcaccatcat taaatacaag ataatcagca agtggattat catctctata
     6361 agctcttcta agaagtgctc ttattcttcc tacaagctct cttacactaa aaggctttgt
     6421 aagataatca tctgccccta tcgctaagcc ttcaatttta tcatcttcct ctattttagc
     6481 agtaagcata ataataggaa catcagatac tgatcttacc tttctgcaaa cttcttctcc
     6541 agaaatttta ggaagcatta aatccaatac gatgagttta atattctctt ttttaaaaat
     6601 ttcaatggct tcttcaccat ttgttgctat atatacttta aaattatcct tttctaaata
     6661 agctttaatt acttccagta ttgtatattc atcatcaact acaagtatat taatggtatc
     6721 tttcattttt cgagcacctc aatacaattt attatttctt acaattatca ttatatcaaa
     6781 aataactaga gattaatctc tagttatttt tgataaattc tttcctcttt ttatattctt
     6841 cttcgctgat ttctccttta gcatacatgt tatcaagagt tttaattgca ttgttattta
     6901 ccttaaaata acccttaaat aattttactg ctgcaacaac tattcctata attattaaaa
     6961 gtcgtattat cataaatatt atgagatatg gccctcccac gcctataaat ccattaccat
     7021 aaccacaacc aaacataata tcaccttcct tttaattttc tataattaaa ttataaaatt
     7081 aaattatgga gcaattatga atgaactatg cctactcata taaacatacc acaaaactaa
     7141 aaataaattc ttactacatt tagtatatat actaaattca ctttacaata gctgaatcat
     7201 actgaataaa tatttgaaaa agtagaaata ttctttttat tacgttataa taaaaaagat
     7261 aaattataca ataataatta tataactgaa tttatactaa cacataagga ggacttagtt
     7321 atgacaaata ataacattaa aataaaaaaa tccatacctt ttgatgctaa aagaaaaatc
     7381 gttgctcatg caacgggaga atcatggtat aatataccac atattactta caactatgag
     7441 ccagacataa caaactttta tgaagaattt gttgaactat ctaaaaaatt aaaaagtgaa
     7501 gggaagaaaa tttcctttaa tagtttaatg ataaaagtta tatcagaggg attgttaagt
     7561 gctgctgatt tgaattcata tttagaatat gatcacgaaa agtgcgatgg tactttacat
     7621 atattagatg aaattaacat agctattccc tggattttat ctgatggttc tcatataact
     7681 ccaagtataa tgaatgctgg taaactatca ttagaagaaa tttctgacta catttcaaat
     7741 ttgactaata aaataaataa ttcagacatt aaagaaataa caaatatact gtcgtcggaa
     7801 ttcagcagtg aaaagcccta tcttgaaggt aaagaaaaag ataattatta taaaatacct
     7861 gacagtgaac gtctaacaaa agaggacttt atttatggaa caataacatt ttcaaatatt
     7921 ggatctcttt atagagaaca aaaaggctct ttttgtctac ttgaagttat accaccacaa
     7981 gtatttgcga taggcctaag ctcagttcag gaaaaaccag gagttttttt agatgacaac
     8041 ggatctaaac aaataggaat aagaaaaaca cttccaatgt gcctagcctt tgatcataga
     8101 gcacttgatt tcagttctat tattccattt ttaaaaaagc tggattccat atttgatgat
     8161 ccatctgtta ttcatcagtg gtaataaagt tttgcattcg taatatatta aaaaatacct
     8221 ggagataaat atattttcag gtatttttta tatttgaatt gatttttttt atatctacaa
     8281 tactactaat taaaacttat gaaaaagcaa cctcaataag ttttccatga tatccacttg
     8341 aaaataatct tacatcacaa aaacaatatg acaattatgc aatattctgt aaagaaaata
     8401 tttatgattt gattcagaaa ttttctttat aaaagagtta tacttgtatt tatttatcta
     8461 aactccttca ttttaaattc aattaaaaat gtagttcttt ccagagtact ttctagggat
     8521 ataattccat tattttgttc aatcaattgt ttaataatat ataatccgaa tccatgatct
     8581 tgtgattttt tagtctttgt agagaatcct ctatcaaaaa ttttattttg aatatcttca
     8641 ggaatcatat ctccattatt agatatttca ataaaaaatt tattatcttt actaaaagaa
     8701 tctattgtta tctctttatt ttcaatatta gatttaactt caaatgcttc aaaggcatta
     8761 tctataatat tacttataat acttattaga tcattttctt taatttctat tgagctgaaa
     8821 ggttcatcaa tcattatatc aaaatttata ttatttttta ctgcataatt actttttata
     8881 gatagcaatc cacttaaaca atcattgcca gtatctatgt atttaaatga tgaatgaagt
     8941 gtatttgaaa ttccatttac atagtttttt atcttttcaa cagtatctgg tttatttaga
     9001 gaacataacc cccatataac attaatatga tttgcgaaat catgcttttc ttgtctaatt
     9061 attttaatta tctcttccat gtctttaatc tgatgttctt gtattttata tttagcttcc
     9121 acatttacaa ttcttctata ttcttttaat ccatttaatt gtattattaa aaatataaaa
     9181 tatacgatga atataaaaca attatatatt ttaagatcct ttacatcaaa aatactaaaa
     9241 ttaataataa gtataagtaa tgcaaaaact ccaatttgca ttattaaatt agaaaaaaga
     9301 ataccttctt gttgaaataa tttgaactta ttaaaatact tactaaatct gaaaagtaat
     9361 aatacaataa ttacttgcat tattttagta gctattataa aaacaagtga atatttaaaa
     9421 ttcaaaaaaa tttgattgag gtttatattc aaaataatca tttcaataat tccaataaaa
     9481 tattcagtta cagaaagcac tgaaaggaat acaaaaaata tgactataga cgcgaatatt
     9541 tttattcttg taatgtaagc caataataaa atatcaaata ttgtaataaa taatatacga
     9601 tagatattgt taatataaat tgtactgaaa taagtcatag acacaaataa tatacaaaat
     9661 aagattgatc ttaatttatt ttctattaaa aatctttttt tattatgtag tgctgcaaaa
     9721 attcctagaa agagcaatga ttcaataaca tctgatagta tttccattat aatagccata
     9781 gtatctcctt taattataac ttttttataa ataccataga taaaaacatt aatccatggc
     9841 atttataaaa aatgaatttc tattttagaa attcatcagg gcactttggc tgatgtccta
     9901 aaagagttga tgttggtact ataactattg ctcctaaaaa taaagctata gaacctaaaa
     9961 atttcattga ttttgatact aacaaatttt taatattttt cattttaatc cccccatcag
    10021 tattgaataa ttactatata tgatattcta caataaattg cttttttcct tcataatttt
    10081 taaaagaaag atatttgaac aaaaaaattt ttcactataa atttatttgt cttcacatta
    10141 tgtattttaa aaataaaaaa agacacatca tatcattttt ttatgataca atgtatcttt
    10201 tttgatatta atattttata tggattttta aatcctaagc aatttaaact caattattta
    10261 gaaacttcct taatagcaac tgctactgca actgaagctc caaccattgg attattatcc
    10321 attccaataa atcccatcat ttcaacgaca gtttaggagt tttactccta aagttgcaca
    10381 aatacttggt taattaaaaa tgtattacac attttactca cgttaaatgt atattattat
    10441 aatatattat ttttatgggt tatgcaatat aaaatcttta cttttcacaa tatttaatta
    10501 aaacatattt gttttaatgc aatgtataat tgtcattata aaacaataca gactaataaa
    10561 ataacctgga ataaaataga acagtgaata ggagtttaaa taatggattt aaaagttaaa
    10621 gagaaaaaat taaagttaga tatacctact gtattcattg ctttaaagaa gaaagaaaca
    10681 ccagtaatcg caaagatttt tgcagtgatt acaattggat atgcgttatc acctattgat
    10741 tttataccag attttatacc tgttataggt ttgttagatg atctgatttt acttccaata
    10801 cttgttgtaa taacaataaa atttatacca gaagaaatat ttaataaatg cagaattgaa
    10861 gcagaaaatt tatggattat cggaaaacct aaaaggtggt attttgcaat accaattgta
    10921 tcaatatggc tggcattcat actgttaatt attaaattag ttataacata atattctttt
    10981 tagacgtaac aaatatagtt cgaaaaaaat aggcaatcta ggatttaccc ttaaactgcc
    11041 tattttaatt atgtattatt taataaaacc ttattaaagc ctataactaa tattatgatt
    11101 ccatcattct aggcgctcac atttcatgca atttgctttt cccctctttt gccactctct
    11161 aggtaattga attttgaatg ttttcatata ttctagtttc ataaaataat acaatgtaat
    11221 tttaaaattc ctaacatgcg tatgaagagt ttgagatgca agatttaaat tatatttaca
    11281 ataaattaca taattacccg tagtttcctg tataatatct ttaatcaaac tgttttcatc
    11341 aaaaatctaa caatagattt ataaccttgt ttgtaatgct ctatagttgt tggtcttaaa
    11401 tttttagctt tacagttatc taaaaacatt aaaagccctg tttaaacatc acgttgtctt
    11461 ctgtaattat tttcgttttt cttctcattt agctaatatt aacacctttc aaaaaaataa
    11521 aaatacacgc taatgaaatt tttatacatt aacgtgtatt ctctaatttt taatttacta
    11581 agtattaaat ctctcttgta ctctgaaaat taagtttgtc cctgaacttg cactttttta
    11641 gaggttcttg cattttctca aatcctctca ttttctttct catacatctc tcgtttgttt
    11701 tttcctccct taacctccgc taataactgc tgcatcacta taatttatca ctatattttc
    11761 tataataatt ccaatccaaa acctgctata atctcattat ttcttctccc tttccccacc
    11821 tacggtggtc ttataagcca cttattaagg gagaataatc cttagattat tctcccttag
    11881 ccattgtatt ttcaatgatt ttctcaatat tttctccaaa tattcgcatt ttaaattcat
    11941 atcatttccc tcaattaccc acccaataat ccccctattt tcttacatct tctctcataa
    12001 ttgaacgaga aaacgaaaaa agcatgaagg tatacaagat ttctcttgca tttcctccat
    12061 gcttcatgga caaactttat ttgctgatta catctaaatc ggcttatttt gaagcttctt
    12121 caatagcaac tgctactgca actgaagctc caaccattgg gttgttaccc attccgataa
    12181 gacccatcat ttcaacgtga gctggaactg atgatgaaaa cactaggttt atagactatt
    12241 tataattata aataaacgca tcttttatga atctatacac acatctaata taattatatt
    12301 aaacttttac taatataatt gcaatacctt tttttacttt ttacaatatt taatttagat
    12361 atatttttat ttctatctta aacacttaaa tactctaaaa aataaagtct ctcaaattta
    12421 aggcagttca aaattcccac ccatgaaaaa taaggatatc ctattttagg acacccttta
    12481 actgtcaagt ataaataatt cttctactgt agtatttaat aatctagcaa gcttcattcc
    12541 taattctagt gtagggttat acttttcatt ctcaattgca ttaatagttt gcctagttac
    12601 ccctagagta tttgccatgt cctcctgcct atatccaagt tcttttctta gtttttttat
    12661 attatttttc atctttgttc atcttccatt ttaaaaaata ttgaactgct atccaaacaa
    12721 aattttgagt tatcaaaaga aataatgaca ccgaatttct attcccatga agataatcat
    12781 aaacaatcca accaaacaaa aatataattg tataagccca agcccatttt attgctttca
    12841 agttaatact taattccatt tcatccattt tcctcataaa atcatctcct aaaatgtaaa
    12901 attcttttta catttatatt ttagcaatga ttcaaattaa atgtcaataa gtttttacat
    12961 ttaataattt ataataactt aaaaaagaca gttaattttt ataactatct ttatacttat
    13021 aaattactat tctaatcctt ttattaatat ttgagtttta gttaatctat tttgagcctc
    13081 ttaaatctct tccttagctt tatttacctt taatgaatct gatactcaag tccattgacc
    13141 gtctttaatt acaaaacatc caaggaataa aaaaaataaa tcaagataaa aatagcatag
    13201 atattatgta attataattt aattattaat taatataacg ccaattgata agccaattat
    13261 tgtaattata agccaaaata ccataatatt ttttattgtt gactgcttat tgtcaatttg
    13321 ttctaacctt tcatatattt ttaattggat caatagtgcc aattcactat catcaatatt
    13381 aagaggtatt tttttataat atttttctcc ttctccaaga tcactaccaa gtgtatatcg
    13441 ttcatcttta tctaattttt tatactcttc ttttgatact tcttcctctg tataaaagat
    13501 atttttcatc aaattttctt tatagacttt aacatcatta tccatttatt aaacctctct
    13561 attaacttat ttttcttcaa attgttttac taatttataa aatgtattct tttttaaatc
    13621 taatcttaca ttatctcttt ataattccta gcaaatgtat ccaatgactt aatgtaaagt
    13681 aaatcatctt cacataaaca ttgttttaat gcttgatgct actgcctatt aaaattctta
    13741 ctgtttacct tatcaataaa tatatctctt tcattaagtc ctaaatccta catttctttt
    13801 atttatatat caatattttt ggtctttact tgataccatt ataatcataa ttatgtatat
    13861 gtatcaataa tttcttcatt attcctaata aaaagtcaaa aaaataaagc attaccattt
    13921 ctggcaacgc cctaaaaatt tcctatatta atatttattt ttatatctat cataattgat
    13981 attatcatcg ctatcattag tagttcttac atatcgcttt gtaattatta aaaatattat
    14041 taatataata ataaaagtta caaaacctac gtccattaaa gttgtattat cataatacat
    14101 tcctatatat gttattatca taggcgaaaa taaaactaaa aatataaatg atgcaaaata
    14161 aaactttttt gtaatcaaaa ttattaaagc cattcctatt attatcccag ctattatacc
    14221 tattaatact ctaccattca atccaaaata ggtattatct ccaaaatttc ttgaaaacca
    14281 tcttccgaaa aaaataccaa acatacttat agattgtgct atacctttgt ttctatcttt
    14341 catataattt ctttcctttg tttaatatta ttataaatat gatattacta tgttttaata
    14401 atatcttcaa taattatatt ttatagctta tagcacatca aaacaaaatc tagaaataat
    14461 attttaacct aatgtataat tttgtatata ttaaatgaaa atcactatac acaattactt
    14521 ggcatagtga ttttttgtcc ataatattat atactcttgt ttaaaatctc cttttgctat
    14581 acctaagcct agattaatta attcattttg agtaaacttt agttttatcc cattgtattc
    14641 caataatata agcattacat atagtcctat tcttttattt ccatctacga aaggatgatt
    14701 atttatcata ctatagcaaa tatttgcaca tttatcttca atagtagggt aaagattttg
    14761 tccattaaaa gttgcttttg aattttctat tgatgatttt aacaattcta tatctcttaa
    14821 ttcacttgat ccacctgtag tttctataag tttgctatga agttttaaaa catattcaat
    14881 tgaaatgtac ttcatttagc taattcctta aacgcttcca tattttcttc taatattcta
    14941 tcagcaatag tatctaactg ttcttctgaa gaagtctctt tactaaattc ttcaaaatcc
    15001 aaaagaatat atttaggctt attatttttc attattacta cagatttatc ttcatcaacc
    15061 atttttgcta ctttagaaaa attctgatta gcttcagaca tagaaatgat tttcttagta
    15121 ttcactagca tataaatccc tccaaatatt tatcttatat atattatatc atatttagga
    15181 taaatttatc ctttttttaa tctataaaga ataataaagt atagaattag attttaagtt
    15241 caattctata ccttatttat ttctactatt ataattctaa gtatgagtaa ttacatactg
    15301 ttcaaattgt gttacaaaat cttcaaaatc tgttggttgc actatttcta cattgtcaat
    15361 atgaattttc ttactattat caatattttg agattgctgt ggtaatttta tattactaaa
    15421 atcaggtgta tttaattgtg gcataaacat acttaattta tctactgtat tcattatatt
    15481 aggaacatta tccgctaata tatttaatcc tcgtgttctt tctgatgtta ctactccact
    15541 acctttattt aataatattg tctcttcacc tttttcattt atttgatatc tatcagtttc
    15601 tggaacatat tcttctccac tagcataccc tatatagttt cctccacgtg caagtgcctt
    15661 tattccagga acattactaa cagtaccata tctacttttt atgtaattaa tagccgccgc
    15721 cgcattatct ataggattta atatttgatt atgaccagat accatattct cagcaaaagt
    15781 agacggtatg gtttgcatta atccttggct cggatgacca gctttagcgt tgctatccca
    15841 attattaata tcattaggat ttccactaga ttcatgcatc gcaatagttt gtaatgctgg
    15901 tagccaactt tcaggtactc cagtcaattt tatagcttct tttaaccaat ctgtcacact
    15961 acctggtaca ttagcaactt gtccattaat tgcaccagtc attccactaa ccttatcagt
    16021 aataaatttt tcaatatcag attcatccat acccttaata agtccttcta tcatatattg
    16081 acctatctta tacataacct tactaggtga atgaatatct aatttttcat tgaatttatc
    16141 taccatcttc ttacataaat tttcaatgtt tttcattaaa tcatcattgc catctgataa
    16201 acctttacca atattaatat caatattttt acctgcacct tgcattgatg atacgaaagg
    16261 agtaattaat cctttaacat tagatattaa tgttctagta ggagttaata cggattcttg
    16321 agtattagtt ataccagtac caatattttt atcagtattt tgaccatatt gtcctgcatt
    16381 attaacaaag ttctgaatca gatttacaac ttcagtaatt aaatcatcta caggtttctt
    16441 aactaataat ttattattag taactgaatc tccaacattt ttatttgtat ctttaccata
    16501 ttgtggtgat tcatttacaa aatgttgaac attatcatca acttcatcta ataattcatt
    16561 aactggcttt ttaactagat ttttattatt ttcaatagta gtccctattg catttaatgt
    16621 atttttagct gattttgatt gtttatcaat gtttttactt gaatcagaat taacatcaat
    16681 agaattagtt ccatttagta tattcataga ttcattatgt ggtataactt gttctccacc
    16741 ttgaaatttt ctagattgtc taccgattac tatttctaat ccattttcag ctacttctgc
    16801 aataccttca tcagcatcat cagtcccctt agcatatcca tctaaggcat ttctactatt
    16861 attaatatta ttttgttgtt ctgctaaatc acttttttta tcatttaatt gatttttttg
    16921 attagatata tcatcctttt gattactaat agcatctttc tgtgcatcaa ttgcttcaaa
    16981 tttagtttca tatgtttttt ctattgcatc cttttgagta ttataatttt cctgtgctat
    17041 atcctttgct ttactagttg catcaatttt atcctgtata tcagttttct gtttttcaat
    17101 agcttggttt tctttccaac gtctataatc ctcttggtct tttgctaatt gttctctggc
    17161 agaatctatt ctagtttggt ctgctaccca catagcttga ccattttcag ttattaatac
    17221 agttttttca ttctgtgcat tatctaattc taattggtct ttctttattt tattctcata
    17281 atcaatagct gaattatttt catcctgtaa atcctttttc ttttgcaaca tatctaattg
    17341 agatttatat ttatcaatta ttgcattttg ttgtgcctgt tcagctttat aacctgttat
    17401 taggcatttt acttaagcta aaaaacattc aaaaaagtca aattattata gacttaattt
    17461 ataggtcaga ttaaataatc tgactcaaaa agaataagat tatttaatct gacgataatt
    17521 agtaaggaga aaatttttta attatgagaa gaaataataa tgataaatat agtaaaaatg
    17581 ccttacggaa taaaaaaata caataaactt tgtaagttta atcaatttcc aagtaaatat
    17641 ggatgcgaag catgtggatt tgaaggtaag ctgtacagac atggatttta ttatagaaac
    17701 ttaattaccc ttaaaggtgc atacaagata gtcatcctgc gttgtaaatg tcaatcctgt
    17761 ggtaaaacct attctcttat acccagtttt attattcctt ataggcaata tgcttatgaa
    17821 gttattctaa cttctattat tatgatgcta aaactaggtt attcctttag taaaatatta
    17881 actcttataa aatctcttaa tattaactac tcatctctta atacaacaga tctatcattt
    17941 tggaaaaata ggctagtaag ctcattatcg agtattcgtt tattttttgc acagtataaa
    18001 ttctataatt ctaacataaa tagcaaatta cctattgata tcataaaaaa aattattatc
    18061 ttttgccgtt taaggcacga ttttaacttg gattattttt tacacatgcc taagtatttc
    18121 ttttgtaaat gataatttaa taggtacaaa ttagatctat cttttttatc aaattaaata
    18181 cttcacactt ttttaatgtc tttttatatc aatcttgtcc tcatttctct tgttctatct
    18241 aaaatttttg tataattcca cacaaccttt aacggtttaa atatcgattt taagtcataa
    18301 ttattaataa aaataggagg ttgataatca atgatattaa aagaatttaa tcaaaagata
    18361 gcattatttc gttattctct gattgcaccc attataacca atacatttac tcagacttct
    18421 gtaaaagatt atttagcaga aattgcagca aagtcttata cactgcctaa cggcaagaaa
    18481 aaagagtatt ctcctgcaac aatcaaagga tggctagttc aatataggaa atatggtatt
    18541 gatggcttat atccaaaatc aagagctgat aaaggtactt ccagaaaaat ttcaaatgaa
    18601 accaaagaat ttattataaa cagtaaatta aattcaccta aaaaaactgc caagtacata
    18661 tatcatgaag ttatagctaa aggttttgaa agtgaaacta gtatttccct gtcaacagta
    18721 actagattta taaataaggc taagataggt tctaaaaagc ttgtacctga tgatagaaga
    18781 gcctttgaat ttgagttttc caatgaatgc tggcaatctg acgtatctgt aggtccttac
    18841 cttactatag aagataaaaa attcaagact tatattatag cttttttaga tgattccagt
    18901 agagtcattg taggatgcaa agcatttttt aaagatgatc ttttatctct tatgtctgta
    18961 tttaaagatg cggtagcatc aaagggaatt cctaaaaaag ttttcgttga taatggaaag
    19021 atatataaaa gtgagcaatt tcatttgatt tgtgcagctc ttggtagtat tttaagtttt
    19081 gcaagaccat attcccctca atctaagggc aaaattgaaa gatggttcca aactatgcaa
    19141 aaacaatgga tgaattcaat taattggaat gattttaaat ctatagacct tttaaatgaa
    19201 tccctgtcgg gttatgttaa cagttataac aacactatac attcctcaat aaacaaaaaa
    19261 ccaattgata agtacatgtc taatgttgaa aatataagat ttattgattc taaaactgaa
    19321 ctagactatt tatttttata taaagtactc cgtactgtaa aaaatgactc cacagtatct
    19381 ataggtacaa aaatatttga agtaccacta aaatatgttg gtgacaaaat aaatatacgc
    19441 tatgatccat catctattga taaagcttat attttttcac aggatggtaa acttgaagat
    19501 actattttcc ctgttaaaaa aattgataat tcaaaaatca gaagaactaa caatactaat
    19561 tctgttgatt tttctgcctt tgaagctaac taa
//
